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At least 1,657 records · Page 92

Optimization of key energy and performance metrics for drug product manufacturing

During the development of pharmaceutical manufacturing processes, detailed systems-based analysis and optimization are required to control and regulate critical quality attributes within specific ranges, to maintain product performance. As discussions on carbon footprint, sustainability, and energy efficiency are gaining prominence, the development and utilization of these concepts in pharmaceutical manufacturing are seldom reported, which limits the potential of pharmaceutical industry in maximizing key energy and performance metrics. Based on an integrated modeling and techno-economic analysis framework previously developed by the authors, this study presents the development of a combined sensitivity analysis and optimization approach to minimize energy consumption while maintaining product quality and meeting operational constraints in a pharmaceutical process. The optimal input process conditions identified were validated against experiments and good agreement resulted between simulated and experimental data. Here, the results also allowed for a comparison of the capital and operational costs for batch and continuous manufacturing schemes under nominal and optimized conditions. Using the nominal batch operations as a basis, the optimized batch operation results in a 71.7% reduction of energy consumption, whereas the optimized continuous case results in an energy saving of 83.3%.

59 BASIC BIOLOGICAL SCIENCES↗

Individual Wave Detection and Tracking within a Rotating Detonation Engine through Computer Vision Object Detection applied to High-Speed Images

Known for their simplistic design and continuous detonation, rotating detonation engines (RDEs) constitute a majority of current pressure gain combustion (PGC) research efforts. Experimental RDE operation times have been continuously extended through the use of rig cooling techniques. As the window of observable behavior is expanded, and as the technology matures toward eventual integration within gas turbines, monitoring techniques must evolve to better match industrial diagnostics. High-speed image analysis techniques prove useful to capture and evaluate the unsteady detonation behavior within the RDE. Traditional image analysis techniques, however, require extensive processing times which prohibit simultaneous monitoring. To better address this problem, a computer vision object detection methodology is proposed to quickly detect individual detonation waves within a single down-axis image. Detonation waves are detected in individual images by the implemented computer vision method You Only Look Once (YOLO) object detection network. In order to detect detonation waves, the network must first be trained using RDE images of interest, for which each required phase of network development is outlined. Detection of waves is improved through proper treatment of the collected image set, variation of Intersection over Union (IoU) and confidence thresholding, and through a parametric study of annotation dimensions. Each detected wave is described by its location and rotational direction, and locations are tracked to calculate wave velocity across each frame, leading to a timestep resolution of 20 µs. Wave velocities are also calculated through a series of frames, leading to a suitable average velocity estimation using as few as 10 frames. Uncertainty analysis accounting for variation in camera framerate, pixel width and annotation centroid locations estimates a total uncertainty of ±4.3% for velocity calculations, using the smallest annotation boxes. This method offers great reductions in processing times, as a step toward real-time monitoring of detonation waves within an RDE. Improving on previous studies, this technique is impartial to wave modes not included in the original training set and calculates wave velocities independent of high-speed pressure data. The ability to isolate waves within predicted bounding boxes will likely facilitate analysis of pixel intensity variation as an estimation of wave strength in future work.

Johnson, Kristyn↗

Investigation and Evaluation of Advanced Spectrum Management Concepts for Aeronautical Communications

With the emergence of new aerial vehicles into the airspace and the continued growth of aviation operations, there will be an increasing demand for voice and data communications within the National Airspace System (NAS). The continued use of existing VHF and UHF frequency allocations is not a sustainable approach, and as a result, a new spectrum management solution is required to support future mission needs. The proposed spectrum management concepts leverage modern advancements such as artificial intelligence (AI) and big data to dynamically optimize the spectrum utilization based on the predicted communications demand throughout the airspace. This technical investigation considers both air-ground and air-air communications networks, and can be applied to both existing applications such as the air traffic control (ATC) system, as well as future applications, such as the emerging Advanced Air Mobility (AAM). To support the evaluation of the proposed concepts and technologies, a modeling and simulation capability is currently under development and will continue to evolve to support new and advanced airspace applications. It is anticipated that this proposed spectrum concept will better serve the spectrum needs of future NAS applications.

Eric J Knoblock↗

Investigation and Evaluation of Advanced Spectrum Management Concepts for Aeronautical Communications

With the emergence of new aerial vehicles into the airspace and the continued growth of aviation operations, there will be an increasing demand for voice and data communications within the National Airspace System (NAS). The continued use of existing VHF and UHF frequency allocations is not a sustainable approach, and as a result, a new spectrum management solution is required to support future mission needs. The proposed spectrum management concepts leverage modern advancements such as artificial intelligence (AI) and big data to dynamically optimize the spectrum utilization based on the predicted communications demand throughout the airspace. This technical investigation considers both air-ground and air-air communications networks, and can be applied to both existing applications such as the air traffic control (ATC) system, as well as future applications, such as the emerging Advanced Air Mobility (AAM). To support the evaluation of the proposed concepts and technologies, a modeling and simulation capability is currently under development and will continue to evolve to support new and advanced airspace applications. It is anticipated that this proposed spectrum concept will better serve the spectrum needs of future NAS applications.

Eric J Knoblock↗

Individual Wave Detection and Tracking within a Rotating Detonation Engine through Computer Vision Object Detection applied to High-Speed Images

Known for their simplistic design and continuous detonation, rotating detonation engines (RDEs) constitute a majority of current pressure gain combustion (PGC) research efforts. Experimental RDE operation times have been continuously extended through the use of rig cooling techniques. As the window of observable behavior is expanded, and as the technology matures toward eventual integration within gas turbines, monitoring techniques must evolve to better match industrial diagnostics. High-speed image analysis techniques prove useful to capture and evaluate the unsteady detonation behavior within the RDE. Traditional image analysis techniques, however, require extensive processing times which prohibit simultaneous monitoring. To better address this problem, a computer vision object detection methodology is proposed to quickly detect individual detonation waves within a single down-axis image. Detonation waves are detected in individual images by the implemented computer vision method You Only Look Once (YOLO) object detection network. In order to detect detonation waves, the network must first be trained using RDE images of interest, for which each required phase of network development is outlined. Detection of waves is improved through proper treatment of the collected image set, variation of Intersection over Union (IoU) and confidence thresholding, and through a parametric study of annotation dimensions. Each detected wave is described by its location and rotational direction, and locations are tracked to calculate wave velocity across each frame, leading to a timestep resolution of 20 µs. Wave velocities are also calculated through a series of frames, leading to a suitable average velocity estimation using as few as 10 frames. Uncertainty analysis accounting for variation in camera framerate, pixel width and annotation centroid locations estimates a total uncertainty of ±4.3% for velocity calculations, using the smallest annotation boxes. This method offers great reductions in processing times, as a step toward real-time monitoring of detonation waves within an RDE. Improving on previous studies, this technique is impartial to wave modes not included in the original training set and calculates wave velocities independent of high-speed pressure data. The ability to isolate waves within predicted bounding boxes will likely facilitate analysis of pixel intensity variation as an estimation of wave strength in future work.

Johnson, Kristyn↗

Development of High Conductivity Lithium-Ion Electrolytes for Low Temperature Cell Applications

NASA has continued interest in developing power sources which are capable of operating at low temperatures (-20 C and below) to enable future missions, such as the Mars Rover and Lander. Thus, under a program sponsored by the Mars Exploration Program, we have been involved in developing Li-ion batteries with improved low temperature performance. To accomplish this task, the focus of the research has been upon the development of advanced electrolyte systems with improved low temperature properties. This had led to the identification of a carbonate-based electrolyte, consisting of 1.0 M LiPF6 in EC + DEC + DMC (33:33:34), which has been shown to have excellent performance at -20 C in Li-ion AA-size prototype cells. Other groups are also actively engaged in developing electrolytes which can result in improved low temperature performance of Li-ion cells, including Polystor, Yardney, and Covalent. In addition to developing cells capable of operation at -20 C, there is continued interest in systems which can successfully operate at even lower temperatures (less than -30 C) and at high discharge rates (greater than C/2). Thus, we are currently focusing upon developing advanced electrolytes which are highly conductive at low temperatures and will result in cells capable of operation at -40 C. One approach to improve the low temperature conductivity of ethylene carbonate-based electrolytes involves adding co-solvents which will decrease the viscosity and extend the liquid range. Candidate solvent additives include formates, acetates, cyclic and aliphatic ethers, lactones, as well as other carbonates. Using this approach, we have prepared a number of electrolytes which contain methyl formate (MF), methyl acetate (MA), ethyl acetate (EA), ethyl proprionate (EP), and 1,2-dimethoxyethane (DME), some of which have been characterized and reported. Other groups have also reported electrolytes based on mixtures of carbonates and acetates. In the present study, electrolytes which have been identified to have good low temperature conductivity and stability were incorporated into lithium-graphite cells for evaluation. Using various electrochemical methods, including ac impedence and DC micropolarization techniques, the film formation characteristics of graphite electrodes in contact with various lectrolyte formulations was investigated.

Smart, M. C.↗

Continuing development of the short-pulsed ablative space propulsion system.

Major advancements have been made in solid propellant pulsed plasma propulsion technology. A LES-6 microthruster has operated for 8900 hours in orbit. Millipound thrustors have been developed and tested at performance levels of as low as 112 watts/mlb. Efficiencies of up to 50% and specific impulse values up to 5000 sec have been measured. An improved microthrustor has operated at 207 watts/mlb continuously for 1440 hours. Correlations of design and performance data exist to allow thrustors to be built to meet a particular level of performance.

Palumbo, D. J.↗

ARM FY2023 Radar Plan

The fundamental objective of the U.S. Department of Energy (DOE) Atmospheric Radiation Measurement (ARM) user facility’s radar capability is to provide high-quality radar observations to the scientific user community with an overarching goal of improving the treatment of clouds and precipitation in climate models. ARM has a complement of 32 radars, including scanning and zenith-pointing varieties (Table 1). The effort to maintain and operate these radars is significant and requires a large, distributed staffing commitment. It has not been feasible to ensure the continuous, high-level operations expected by the ARM user community for all radars at all times, so priorities are established to routinely manage select radar operations every fiscal year. These priorities for FY23 are listed herein.

54 ENVIRONMENTAL SCIENCES↗

Pre-metered coating flow models with Goma 7: Workflow Tutorial

Tutorials for modeling of slot-die and slide-die coating flows with Goma 7, an open source finite element code, are presented. The tutorials cover the workflow to attaining steady state solutions for these flows, and continuation strategies for navigating the operating windows. Advanced topics of coating window prediction, automated multiparameter continuation, non-Newtonian rheology, dynamic contact line modeling, and some more solution strategies are also covered.

08 HYDROGEN↗

Lunar impact: A history of Project Ranger

Complete history of the Ranger project is provided as a tool for understanding the evolution and operational form of NASA's continuing progress of unmanned space exploration. Basic management techniques, flight operating procedures and technology for NASA's later unmanned lunar and planetary missions were reviewed. Methods for selecting experiments and integrating them with the spacecraft were also investigated.

Hall, R. C.↗

Overview of NASA Earth Observing Systems Terra and Aqua Moderate Resolution Imaging Spectroradiometer Instrument Calibration Algorithms and On-Orbit Performance

Since launch, the Terra and Aqua moderate resolution imaging spectroradiometer (MODIS) instruments have successfully operated on-orbit for more than 9 and 6.5 years, respectively. Iv1ODIS, a key instrument for the NASA's Earth Observing System (EOS) missions, was designed to make continuous observations for studies of Earth's land, ocean, and atmospheric properties and to extend existing data records from heritage earth-observing sensors. In addition to frequent global coverage, MODIS observations are made in 36 spectral bands, covering both solar reflective and thermal emissive spectral regions. Nearly 40 data products are routinely generated from MODIS' observations and publicly distributed for a broad range of applications. Both instruments have produced an unprecedented amount of data in support of the science community. As a general reference for understanding sensor operation and calibration, and thus science data quality, we ;provide an overview of the MODIS instruments and their pre-launch calibration and characterization, and describe their on-orbit calibration algorithms and performance. On-orbit results from both Terra and Aqua MODIS radiometric, spectral, and "spatial calibration are discussed. Currently, both instruments, including their on-board calibration devices, are healthy and are expected to continue operation for several }rears to come.

Xiong, Xiaoxiong↗

Engineering Ulysses extended mission

The Ulysses Mission is a collaboration between the European Space Agency (ESA) and the National Aeronautics and Space Administration (NASA). The mission is unique, enabling exploration of the heliosphere within a few astronomical units of the Sun over a full range of heliographic latitudes adding a third dimension to our understanding of the Solar System. The advanced scientific instrumentation on Ulysses continually measures the properties of the heliospheric magnetic field, the solar wind, solar radio bursts and plasma waves, galactic cosmic rays, energetic particles, solar X-rays, and interstellar neutral gas. By the end of 1995, the spacecraft will have completed measurements at heliographic latitudes up to 80 degrees over a single orbit of the Sun. The properties of the heliosphere are solar cycle dependent, and Ulysses' first orbit of the Sun will have taken place around a solar minimum. In order to characterize the heliosphere over a full (11 year) solar cycle, it is desirable to continue measurements over a second orbit of the Sun, a new Odyssey that will extend through 2001. Since the spacecraft was only designed for a five-year mission, a number of technical challenges have been surmounted in order to demonstrate the engineering feasibility of this unparalleled scientific opportunity. This paper describes the changes that were necessary to the Ulysses mission engineering and mission operations in order to ensure continual, effective payload operation throughout 1996-2001.

Standley, Shaun↗

Practical Operational Readiness Gambits: Operations Training Simulations for the Curiosity Rover

The Mars Science Laboratory team had been puttingin effort to make a Training Venue to allow for parallel shadowtactical operations for trainees to actively work alongside theprime tactical operations personnel without affecting operations,since staffing constraints and shortened operations timelineswere straining the tactical process in supporting operationstrainees in the traditional way. The COVID- 19 Pandemic presentedfurther challenges in continuing on-console training forMSL operations trainees. The MSL operations team switched tofully remote operations, thus hampering the direct mentorshipa trainee would normally receive while on site at JPL. TheMars 2020 training team had developed a concept for roveroperations training simulations based on Johnson Space Center’sextensive simulations training program for astronauts andflight controllers. The MSL team borrowed this idea, and implementedthese training simulations which are called PracticalOperational Readiness Gambits (PORGs). The PORGs so farhave focused on the Science Planner and Rover Planner roles,which are two crucial roles in tactical operations that engagein key interactions throughout a shift. PORGs are based onactual sol scenarios that have occurred on Mars and follow thetactical operations process and timeline as closely as possible.However, unlike an operations shift, PORGs can slow down orpause to allow for more mentoring time. PORGs can focus onparticular skills to test the trainees on their understanding ofa concept. PORGs increase in complexity with each scenario toease the trainees into more typical tactical operations workloads.As more trainees join the MSL operations team, more roles arebeing incorporated into PORGs. There are plans to incorporatecertified operations personnel into PORGs to practice anomalyresponse situations. PORGs have become an essential part of theMSL operations training program and will continue even afterthe return to on-site operations at JPL.

Gajeway, Jocelyn↗

Community-wide Validation of Geospace Model Ground Magnetic Field Perturbation Predictions to Support Model Transition to Operations

In this paper we continue the community-wide rigorous modern space weather model validation efforts carried out within GEM, CEDAR and SHINE programs. In this particular effort, in coordination among the Community Coordinated Modeling Center (CCMC), NOAA Space Weather Prediction Center (SWPC), modelers, and science community, we focus on studying the models' capability to reproduce observed ground magnetic field fluctuations, which are closely related to geomagnetically induced current phenomenon. One of the primary motivations of the work is to support NOAA SWPC in their selection of the next numerical model that will be transitioned into operations. Six geomagnetic events and 12 geomagnetic observatories were selected for validation.While modeled and observed magnetic field time series are available for all 12 stations, the primary metrics analysis is based on six stations that were selected to represent the high-latitude and mid-latitude locations. Events-based analysis and the corresponding contingency tables were built for each event and each station. The elements in the contingency table were then used to calculate Probability of Detection (POD), Probability of False Detection (POFD) and Heidke Skill Score (HSS) for rigorous quantification of the models' performance. In this paper the summary results of the metrics analyses are reported in terms of POD, POFD and HSS. More detailed analyses can be carried out using the event by event contingency tables provided as an online appendix. An online interface built at CCMC and described in the supporting information is also available for more detailed time series analyses.

MAGNETIC↗

Fuel-Cell Power Source Based on Onboard Rocket Propellants

The use of onboard rocket propellants (dense liquids at room temperature) in place of conventional cryogenic fuel-cell reactants (hydrogen and oxygen) eliminates the mass penalties associated with cryocooling and boil-off. The high energy content and density of the rocket propellants will also require no additional chemical processing. For a 30-day mission on the Moon that requires a continuous 100 watts of power, the reactant mass and volume would be reduced by 15 and 50 percent, respectively, even without accounting for boiloff losses. The savings increase further with increasing transit times. A high-temperature, solid oxide, electrolyte-based fuel-cell configuration, that can rapidly combine rocket propellants - both monopropellant system with hydrazine and bi-propellant systems such as monomethyl hydrazine/ unsymmetrical dimethyl hydrazine (MMH/UDMH) and nitrogen tetroxide (NTO) to produce electrical energy - overcomes the severe drawbacks of earlier attempts in 1963-1967 of using fuel reforming and aqueous media. The electrical energy available from such a fuel cell operating at 60-percent efficiency is estimated to be 1,500 Wh/kg of reactants. The proposed use of zirconia-based oxide electrolyte at 800-1,000 C will permit continuous operation, very high power densities, and substantially increased efficiency of conversion over any of the earlier attempts. The solid oxide fuel cell is also tolerant to a wide range of environmental temperatures. Such a system is built for easy refueling for exploration missions and for the ability to turn on after several years of transit. Specific examples of future missions are in-situ landers on Europa and Titan that will face extreme radiation and temperature environments, flyby missions to Saturn, and landed missions on the Moon with 14 day/night cycles.

Ganapathi, Gani↗

Near-infrared spectra and molar absorption coefficients of trivalent lanthanides dissolved in molten LiCl–KCl eutectic

Determining the concentration of the dissolved lanthanide species in LiCl–KCl eutectic salt is important to the development of pyrochemical reprocessing of used nuclear fuel. In this process, lanthanide fission products are found dissolved in the electrorefiner electrolyte in their trivalent oxidation state. The presence of dissolved trivalent lanthanides increases the liquidus temperature of the electrolyte mixture and can lead to the formation of insoluble oxide or oxychloride phases and must therefore be continuously monitored and controlled during the operation. Absorbance spectroscopy is a promising method for continuous measurement of the concentration of lanthanides and other elements dissolved in the electrolyte. The absorption of light by elements is linearly proportional to the concentration of the element for relatively dilute solutions according to the Beer-Lambert law. Although measurement of the absorption of ultraviolet and visible range light by lanthanides in LiCl–KCl eutectic molten salt have been explored previously, near infrared (NIR) absorption spectroscopy has received far less attention. It may, however, provide a better analytical signal when insoluble phases are present due to less Raleigh scattering compared to shorter wavelength radiation. Additionally, it may allow for concentration determination for certain elements using NIR absorption features where UV and visible range features are overlapping with features from other species. In this study, we report the UV–Vis–NIR spectra of the trivalent lanthanide chlorides of neodymium, samarium, and dysprosium in LiCl–KCl eutectic. Molar absorption coefficients are reported for analytically useful absorption maxima, with a focus on the molar absorption coefficients for NIR absorption maxima which have not been reported previously. Additionally, we observe a NIR-range absorption band of Nd3+ which was previously predicted but never experimentally observed. Here, we compare the calculated crystal field levels to the newly observed absorbance band and find them to be in good agreement with previous predictions.

11 NUCLEAR FUEL CYCLE AND FUEL MATERIALS↗

Analysis of Loss-of-Offsite-Power Events: 2021 Update

Loss-of-offsite power (LOOP) can have a negative impact on a nuclear power plant’s ability to achieve and maintain safe shutdown conditions. LOOP event frequencies and times required for subsequent restoration of offsite power are important inputs to plant probabilistic risk assessments. This report presents a statistical and engineering analysis of LOOP frequencies and durations at U.S. commercial nuclear power plants. The data used in this study were based on the operating experience during calendar years 1987–2021, while the most recent 15-year data (i.e., from 2007–2021) were used for most analyses in this report. LOOP events during critical operation that did not result in a reactor trip are not included. Frequencies and durations were determined for four LOOP event categories: plant-centered, switchyard-centered, grid-related, and weather-related. These categories (and the All-LOOPs group which contains all LOOPs without regarding of the four categories) could be further grouped by whether a LOOP event occurred during critical operation, during shutdown operation, or during all operations. The following decreasing trends in the LOOP occurrence rates were identified for the most recent 10-year period (2012–2021): All-LOOPs during critical operation, switchyard-centered LOOPs during critical operation, and grid-related LOOPs during critical operation. Adverse trends in LOOP durations continue for switchyard-centered LOOPs during all operations, All-LOOPs during all operations, and All-LOOPs during shutdown operation for the 1997–2021 period. Statistical tests show the LOOP counts for the period of 2007–2021 are not uniformly distributed across the 12 months, and variation among the months exists for grid-related LOOPs during all operations, All-LOOPs during all operations, and All-LOOPs during critical operation. The engineering analysis of LOOP data showed for the period of 2007–2021, the equipment failure events were dominated by failures of relay and other; human errors have been less frequent and occurred primarily in maintenance and switching; and weather were dominated by tornadoes then by lightning and hurricane. Weather was the cause for 45% of LOOPs for the last fifteen years (2007– 2021) but only for 20% of LOOPs for the previous 20 years (1987–2006) .

22 GENERAL STUDIES OF NUCLEAR REACTORS↗

Performance characteristics of point-focusing distributed-receiver solar Brayton systems

Due to variations in solar insolation, it may be necessary or desirable to operate solar energy systems continuously in off-design conditions. Design of solar energy systems should maximize system efficiency at the design point and throughout the range of operational solar insolation. The solar power system considered in this study consists of a point-focusing concentrator, a cavity receiver, an open cycle gas turbine engine, and a heat regenerator. A computer simulation model was developed to predict off-design system performance. Results showing system efficiency and associated subsystems interface requirements are presented for various turbine inlet temperatures and engine speeds.

El Gabalawi, N.↗