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The UPR regulator IRE1 promotes balanced organ development by restricting TOR-dependent control of cellular differentiation in Arabidopsis

Proteostasis of the endoplasmic reticulum (ER) is controlled by sophisticated signaling pathways that are collectively called the unfolded protein response (UPR) and are initiated by specialized ER membrane-associated sensors. The evidence that complete loss-of-function mutations of the most conserved of the UPR sensors, inositol-requiring enzyme 1 (IRE1), dysregulates tissue growth and development in metazoans and plants raises the fundamental question as to how IRE1 is connected to organismal growth. To address this question, we interrogated the Arabidopsis primary root, an established model for organ development, using the tractable Arabidopsis IRE1 mutant ire1a ire1b, which has marked root development defects in the absence of exogenous stress. We demonstrate that IRE1 is required to reach maximum rates of cell elongation and root growth. We also established that in the actively growing ire1a ire1b mutant root tips the Target of Rapamycin (TOR) kinase, a widely conserved pro-growth regulator, is hyperactive, and that, unlike cell proliferation, the rate of cell differentiation is enhanced in ire1a ire1b in a TOR-dependent manner. By functionally connecting two essential growth regulators, these results underpin a novel and critical role of IRE1 in organ development and indicate that, as cells exit an undifferentiated state, IRE1 is required to monitor TOR activity to balance cell expansion and maturation during organ biogenesis.

59 BASIC BIOLOGICAL SCIENCES↗

Acoustic Travel-Time Tomography for Wind Energy

New remote sensing technologies for direct observation of the atmospheric flow in the proximity of operating wind turbines are necessary for the advancement of wind turbine design, wind plant control, and the validation of high-fidelity numerical models; fundamental goals of the DOE Wind Energy Technology Office's (WETO's) A2e program. Modern remote sensing technologies for commercial and research applications rely on the backscatter of light or sound waves, which limits spatial and temporal resolution and cannot produce reliable flow estimates near solid bodies or reflective surfaces. Acoustic tomography (AT) is an innovative sensing technology based on fundamental thermodynamic properties of the atmosphere and an inverse algorithm that can reconstruct both velocity and temperature fields within a network of acoustic transducers. AT relies on the direct travel path of acoustic signals between speakers and microphones in the network and can achieve much higher resolutions than conventional backscatter technologies. For wind energy R&D applications, AT represents an extremely economical option over other remote sensing technologies, integrating mature and commonly available acoustic and signal processing hardware. This report is intended as an update on the development of the AT array on the NREL Flatirons Campus (FC) and includes a brief review of the instrumentation, the calibration of equipment, signal processing, and resulting flow field estimates. Designs for future AT systems and applications are detailed in this report, including summaries of new capabilities, engineering and theoretical challenges, and anticipated costs help to outline future directions for AT technology R\&D. The potential for application of AT to utility-scale turbines is also discussed. Investing in the development of the proposed instrument will establish AT as a transformational RS technique that represents a significant advance in measurement instrumentation, enabling new fundamental insights into the structure of the atmospheric boundary layer and supporting applications for wind energy, pollution transport, and resource characterization. AT is also an extremely economical option over other RS instruments, integrating mature and commonly available acoustic and signal processing hardware.

17 WIND ENERGY↗

Validation of bonded composite doubler technology through application oriented structural testing

One of the major thrusts established under the FAA's National Aging Aircraft Research Program is to foster new technologies associated with civil aircraft maintenance. Recent DOD and other government developments in the use of bonded composite patches on metal structures has supported the need for research and validation of such doubler applications on U.S. certificated airplanes. Composite patching is a rapidly maturing technology which shows promise of cost savings on aging aircraft. Sandia Labs is conducting a proof-of-concept project with Delta Air Lines, Lockheed Martin, Textron, and the FAA which seeks to remove any remaining obstacles to the approved use of composite doublers. By focusing on a specific commercial aircraft application - reinforcement of the L-1011 door frame - and encompassing all 'cradle-to-grave' tasks such as design, analysis, installation, and inspection, this program is designed to prove the capabilities of composite doublers. This paper reports on a series of structural tests which have been conducted on coupons and subsize test articles. Tension-tension fatigue and residual strength tests attempted to grow engineered flaws in coupons with composite doublers bonded to aluminum skin. Also, structures which modeled key aspects of the door corner installation were subjected to extreme tension, shear, and bending loads. In this manner it was possible to study strain fields in and around the Lockheed-designed composite doubler using realistic aircraft load scenarios and to assess the potential for interply delaminations and disbonds between the aluminum and the laminate. The data acquired was also used to validate finite element models (FEM) and associated Damage Tolerance Analyses.

Roach, Dennis↗

Overview and Summary of Advanced UVOIR Mirror Technology Development (AMTD) Project

ASTRO2010 Decadal Survey stated that an advanced large-aperture ultraviolet, optical, near-infrared (UVOIR) telescope is required to enable the next generation of compelling astrophysics and exoplanet science; and, that present technology is not mature enough to affordably build and launch any potential UVOIR mission concept. AMTD is a multiyear effort to develop, demonstrate and mature critical technologies to TRL-6 by 2018 so that a viable flight mission can be proposed to the 2020 Decadal Review. AMTD builds on the state of art (SOA) defined by over 30 years of monolithic & segmented ground & space-telescope mirror technology to mature six key technologies: center dotLarge-Aperture, Low Areal Density, High Stiffness Mirror Substrates: Both (4 to 8 m) monolithic and (8 to 16 m) segmented telescopes require larger and stiffer mirrors. center dotSupport System: Large-aperture mirrors require large support systems to ensure that they survive launch, deploy on orbit, and maintain a stable, undistorted shape. center dotMid/High Spatial Frequency Figure Error: Very smooth mirror is critical for producing high-quality point spread function (PSF) for high contrast imaging. center dotSegment Edges: The quality of segment edges impacts PSF for high-contrast imaging applications, contributes to stray light noise, and affects total collecting aperture. center dotSegment to Segment Gap Phasing: Segment phasing is critical for producing high-quality temporally-stable PSF. center dotIntegrated Model Validation: On-orbit performance is driven by mechanical & thermal stability. Compliance cannot be 100% tested, but relies on modeling. Because we cannot predict the future, AMTD is pursuing multiple design paths to provide the science community with options to enable either large aperture monolithic or segmented mirrors with clear engineering metrics traceable to science requirements

Stahl, H. Philip↗

OpenNEX: An open collaboration platform for the earth science community

Satellite data from the past several decades provide the most consistent record of land-surface processes that form the basis for scientific assessments of the impacts of climate variations and changes on the environment and human social-economical activities. During this time, scientific research on the characterization and assessment of environmental changes had tended to focus on large-scale land-surface changes with significant social-economic impacts. Increasingly, attention is shifting toward changes that occur more locally and that most directly relate to the everyday life of the majority of the population. In addition, there has been needs to develop management and policy decision support systems that are based on local environmental information. Almost at the same time, the advancement in sensor technology has allowed us to collect an unprecedented volume of environmental data. These data must be curated and analyzed to extract useful information for research and decision support purposes. Established in 2013 and funded by NASA, the Open NASA Earth eXchange (OpenNEX; https://opennex.org/ , Jia et al., 2019 ) project partnered with Amazon Web Services (AWS) to make available a large amount of Earth observing data, modeling results, and analysis tools on the AWS. OpenNEX provides researchers, developers, educators, and ordinary users with easy access to an integrated Earth science computational and data platform, enabling citizen scientists and application developers to realize the full value of NASA data assets and software tools. To encourage the public's engagement in this project, NASA ran virtual workshops and prize competitions. The virtual workshops provided online lectures and tutorials about how prominent scientists used the data in their research and the tutorials gave examples how to use the tools to interrogate the data in the Amazon cloud. Finally, the prize competitions allowed much wider participation in the OpenNEX project and enable testing the non-traditional projects and out-of-box ideas. OpenNEX has continued to evolve and mature. Here, we highlight new features and functionalities available to the community.

Jian Zhang↗

NASA Advanced Reconfigurable Electrified Aircraft Laboratory (AREAL)

The rapid maturation of electrified aircraft and the underlying technologies has outpaced the development of corresponding standards and guidelines. This is especially true with respect to the design and test of high voltage power systems and equipment. To expedite the development of these standards and guidelines, the National Aeronautics and Space Administration (NASA) Revolutionary Vertical Lift Technology (RVLT) Project has designed and built the Advanced Reconfigurable Electrified Aircraft Laboratory (AREAL). AREAL is a 200 kW High Voltage DC (HVDC) test facility that can be reconfigured to test various electrical power system (EPS) architectures and/or different types of Utilization Equipment (UE). This paper will cover AREAL and its capabilities, the testing planned within AREAL, and how the tests performed within AREAL will inform developing HVDC Power System standards, test methods and guidelines, and models.

Aerospace↗

Initial Validation of the Neutron Physics Codes in COSINE Using the MIT BEAVRS Benchmark

A software package for nuclear power plant design and analysis, known as COSINE, has been developed by State Nuclear Power Software Development Center (SNPSDC). A detailed benchmark called BEAVRS which includes measured reactor data is presented by MIT. The BEAVRS benchmark is based on a commercial power plant and provides a highly-detailed Pressurized Water Reactor (PWR) specification with measured operational data that has been used to validate the neutron physics codes in COSINE. In this paper, a COSINE core model is prepared to calculate the BEAVRS benchmark. The first stage validation is focused on the depletion of two cycles and initial physics test of cycle 1. The calculation results agree well with the measured data. It could be confirmed that the COSINE codes package has the ability to design and analyze a commercial PWR core, and the precision of the calculation results can meet the requirements of industrial design and analysis. A calculation of MIT BEAVRS benchmark using COSINE has been performed in this paper. A lot of measurements are given in the benchmark specification which can be used for code validation. The calculation includes a depletion calculation of both two cycles and a calculation of the initial physics test of cycle 1. COSINE neutron physics codes use the mature industrial calculation method which can achieve reasonable results with acceptable accuracy and speed. Through the calculation, it can be seen that the difference of critical boron concentration calculated from cos Nu is less than 25 pcm compared with measured data. And the relative difference of rod worth is less than 10%. The isothermal temperature coefficient difference between measurement and calculation is less than 1 pcm/deg. F. All results meet the criteria of ANS. The validation for measurements after initial physics test following a more complex power history and the validation for in-core detector signals are underway. (authors)

97 MATHEMATICS AND COMPUTING↗

Structure of metallochaperone in complex with the cobalamin-binding domain of its target mutase provides insight into cofactor delivery

G-protein metallochaperone MeaB in bacteria [methylmalonic aciduria type A (MMAA) in humans] is responsible for facilitating the delivery of adenosylcobalamin (AdoCbl) to methylmalonyl-CoA mutase (MCM), the only AdoCbl-dependent enzyme in humans. Genetic defects in the switch III region of MMAA lead to the genetic disorder methylmalonic aciduria in which the body is unable to process certain lipids. Here, we present a crystal structure of Methylobacterium extorquens MeaB bound to a nonhydrolyzable guanosine triphosphate (GTP) analog guanosine-5'-[(β,γ)-methyleno]triphosphate (GMPPCP) with the Cbl-binding domain of its target mutase enzyme (MeMCM cbl ). This structure provides an explanation for the stimulation of the GTP hydrolyase activity of MeaB afforded by target protein binding. We find that upon MCM cbl association, one protomer of the MeaB dimer rotates ~180°, such that the inactive state of MeaB is converted to an active state in which the nucleotide substrate is now surrounded by catalytic residues. Importantly, it is the switch III region that undergoes the largest change, rearranging to make direct contacts with the terminal phosphate of GMPPCP. These structural data additionally provide insights into the molecular basis by which this metallochaperone contributes to AdoCbl delivery without directly binding the cofactor. Our data suggest a model in which GTP-bound MeaB stabilizes a conformation of MCM that is open for AdoCbl insertion, and GTP hydrolysis, as signaled by switch III residues, allows MCM to close and trap its cofactor. Substitutions of switch III residues destabilize the active state of MeaB through loss of protein:nucleotide and protein:protein interactions at the dimer interface, thus uncoupling GTP hydrolysis from AdoCbl delivery.

59 BASIC BIOLOGICAL SCIENCES↗

Life Cycle Systems Engineering Approach to NASA's 2nd Generation Reusable Launch Vehicle

The overall goal of the 2nd Generation RLV Program is to substantially reduce technical and business risks associated with developing a new class of reusable launch vehicles. NASA's specific goals are to improve the safety of a 2nd- generation system by 2 orders of magnitude - equivalent to a crew risk of 1 -in- 10,000 missions - and decrease the cost tenfold, to approximately $1,000 per pound of payload launched. Architecture definition is being conducted in parallel with the maturating of key technologies specifically identified to improve safety and reliability, while reducing operational costs. An architecture broadly includes an Earth-to-orbit reusable launch vehicle, on-orbit transfer vehicles and upper stages, mission planning, ground and flight operations, and support infrastructure, both on the ground and in orbit. The systems engineering approach ensures that the technologies developed - such as lightweight structures, long-life rocket engines, reliable crew escape, and robust thermal protection systems - will synergistically integrate into the optimum vehicle. Given a candidate architecture that possesses credible physical processes and realistic technology assumptions, the next set of analyses address the system's functionality across the spread of operational scenarios characterized by the design reference missions. The safety/reliability and cost/economics associated with operating the system will also be modeled and analyzed to answer the questions "How safe is it?" and "How much will it cost to acquire and operate?" The systems engineering review process factors in comprehensive budget estimates, detailed project schedules, and business and performance plans, against the goals of safety, reliability, and cost, in addition to overall technical feasibility. This approach forms the basis for investment decisions in the 2nd Generation RLV Program's risk-reduction activities. Through this process, NASA will continually refine its specialized needs and identify where Defense and commercial requirements overlap those of civil missions.

Thomas, Dale↗

The formation of quiescent glomerular endothelial cell monolayer in vitro is strongly dependent on the choice of extracellular matrix coating

Background and aims: Nephropathy involves pathophysiological changes to the glomerulus. The primary glomerular endothelial cells (GEnCs) have emerged as an important tool for studying glomerulosclerotic mechanisms and in the screening process for drug-candidates. The success of the studies is dependent on the quality of the cell model. Therefore, we set out to establish an easy, reproducible model of the quiescent endothelial monolayer with the use of commercially available extracellular matrices (ECMs). Methods: Primary hGEnCs were seeded on various ECMs. Cell adhesion was monitored by an impedance sensing system. The localization of junctional proteins was assessed by immunofluorescence and the barrier function by passage of fluorescent dextrans and magnitude of VEGF response. Results: All ECM matrices except recombinant human laminin 111 (rhLN111) supported comparable cell proliferation. Culturing hGEnCs on rhLN521, rhLN511 or fibronectin resulted in a physiologically relevant barrier to 70 kDa dextrans which was 82% tighter than that formed on collagen type IV. Furthermore, only hGEnCs cultured on rhLN521 or rhLN511 showed plasma-membrane localized zonula occludens-1 and vascular endothelial cadherin indicative of proper tight and adherens junctions (AJ). Conclusion: We recommend culturing hGEnCs on the mature glomerular basement membrane laminin - rhLN521 – which, as the only commercially available ECM, promotes all of the characteristics of the quiescent hGEnC monolayer: cobblestone morphology, well-defined AJs and physiological perm-selectivity. - Highlights: • rhLN521, rhLN511 and hFN assure physiologically relevant permeability. • rhLN521 and rhLN511 ensure best cell morphology and adherens junction formation. • Collagen IV and I based coating results in disorganized hGEnC monolayer. • Physiologically relevant ECM may lead to down-regulation of self-produced matrices.

60 APPLIED LIFE SCIENCES↗

Defect-Driven Oxide Transformations and the Electrochemical Interphase

The redox reaction pathway is crucial to the sustainable production of the fuels and chemicals required for a carbon-neutral society. Our society is becoming increasingly dependent on devices using batteries and electrolyzers, all of which rely on a series of redox reactions. The overall properties of oxide materials make them very well suited for such electrochemical and catalytic applications due to their associated cationic redox properties and the static site-adsorbate interactions. As these technologies have matured, it has become apparent that defect-driven redox reactions, defect-coupled diffusion, and structural transformations that are both time- and rate-dependent are also critical materials processes. This change in focus, considering not only redox properties but also more complex, dynamic behaviors, represents a new research frontier in the molecular sciences as they are strongly linked to device operation and degradation and lie at the heart of various phenomena that take place at electrochemical interfaces. Fundamental studies of the structural, electronic, and chemical transformation mechanisms are key to the advancement of materials and technological innovations that could be implemented in various electrochemical systems. In this Account, we focus on recent studies and advances in characterizing and understanding the dynamic redox evolution and structural transformations that take place in model perovskites and layered oxides under reactive conditions and correlate them with degradation mechanisms and operations in electrolyzers and batteries. We show that the dynamic evolution of oxygen vacancies and cationic migration in the surface or bulk occurs at the solid-liquid interface, using a combination of different synchrotron-based Xray spectroscopies and scattering probes. Detailed redox-structure-reactivity correlation studies show how defects and diffusion processes can be tailored to drive various physical and chemical transformations in electrolyzers and batteries. We also highlight a strong correlation between oxygen redox reactivity and structural reorganization in both model thin films and particles, helping to bridge the gap between fundamental studies of the reaction mechanism and device applications. Finally, on the basis of these findings, we discuss strategies to probe and tune the redox reactivity and structural stability of the redox-active oxide interphase toward devising efficient pathways for energy and chemical harvesting.

37 INORGANIC, ORGANIC, PHYSICAL, AND ANALYTICAL CH↗

HTTR 3 D Cross Section Generation with Serpent and MAMMOTH

The High Temperature Test Reactor (HTTR) is a graphite moderated thermal reactor with a nominal power output of 30 MWth. The purpose of this work is to prepare a set of neutron cross sections for use in the transient analyses of three Loss of Forced Cooling (LOFC) events planned for this reactor. The cross sections are generated with the Serpent 2 3 D Monte Carlo code to include the axial heterogeneity and the strong axial coupling of this core. The approach yields good agreement of results when compared to previously used 2 D lattice models, which require a fine spatial discretization and, surprisingly, comes at a higher computational cost. In addition, the temperature distribution must be considered to obtain reasonable cross sections and the axial leakage component dominates the spectral effects in the core. Consequently, a temperature model as a function of the fuel and moderator temperatures is adopted, and the core is depleted to 390 effective full-power days (EFPDs). A full tabulation of cross sections is prepared at this burnup point for a variety of fuel and moderator temperatures. Next, the multiphysics reactor application MAMMOTH is used to evaluate the quality of these cross sections using a diffusion solver. As expected, the homogenization error in the cross sections is significant and the Super Homogenization (SPH) correction from MAMMOTH is necessary to preserve key reaction rates. The SPH corrected MAMMOTH results are in excellent agreement with the Serpent results and reproduce both the reference power profile and temperature coefficients at each tabulation point. This fact confirms the accuracy of the SPH corrected cross sections and demonstrates the maturity of using Serpent 2 and MAMMOTH for 3 D cross section generation, even for reactors as complex as the HTTR. Finally, the authors recommend that the cross sections should be parametrized with the local burnup and that a full core burnup calculation with coupled thermal fluids would provide a better estimate of the initial condition for any subsequent transient analysis. Unfortunately, this was not within the scope of this work, and direct analysis with these tabulations should be considered as a first order approximation, at best.

11 NUCLEAR FUEL CYCLE AND FUEL MATERIALS↗

Altered skeletal pattern of gene expression in response to spaceflight and hindlimb elevation

Spaceflight leads to osteopenia, in part by inhibiting bone formation. Using an animal model (hindlimb elevation) that simulates the weightlessness of spaceflight, we and others showed a reversible inhibition of bone formation and bone mineralization. In this study, we have measured the mRNA levels of insulin-like growth factor I (IGF-I), IGF-I receptor (IGF-IR), alkaline phosphatase, and osteocalcin in the tibiae of rats flown aboard National Aeronautics and Space Administration Shuttle Flight STS-54 and compared the results with those obtained from their ground-based controls and from the bones of hindlimb-elevated animals. Spaceflight and hindlimb elevation transiently increase the mRNA levels for IGF-I, IGF-IR, and alkaline phosphatase but decrease the mRNA levels for osteocalcin. The changes in osteocalcin and alkaline phosphatase mRNA levels are consistent with a shift toward decreased maturation, whereas the rise in IGF-I and IGF-IR mRNA levels may indicate a compensatory response to the fall in bone formation. We conclude that skeletal unloading during spaceflight or hindlimb elevation resets the pattern of gene expression in the osteoblast, giving it a less mature profile.

NASA Discipline Musculoskeletal↗

Spectral Mass-Gauging of Propellant Tanks

An overview of our recent results on the development of Spectral Mass-Gauging (SMG) technology for model-free gauging of propellants in microgravity applications will be presented. The technology is based on application a rigorous result from spectral theory – the Weyl’s Law – which relates the counting function of natural modes in a resonator with its volume. Development of the SMG includes theory of acoustic response of propellant tank, hardware and procedure characterization and optimization, development of data pre-processing approaches and software for automatic mode identification and counting. Main accomplishments in each field of the technology development will be presented. SMG has been tested recently in 1-g on a flight tank filled with water or LN2. We will present results of the tests and discuss their implications for the technology development. The presentation will conclude with a summary of the next steps in the technology maturation.

Mass-gauging↗

Probing the in situ volumes of Arabidopsis leaf plastids using three‐dimensional confocal and scanning electron microscopy

SUMMARY Leaf plastids harbor a plethora of biochemical reactions including photosynthesis, one of the most important metabolic pathways on Earth. Scientists are eager to unveil the physiological processes within the organelle but also their interconnection with the rest of the plant cell. An increasingly important feature of this venture is to use experimental data in the design of metabolic models. A remaining obstacle has been the limited in situ volume information of plastids and other cell organelles. To fill this gap for chloroplasts, we established three microscopy protocols delivering in situ volumes based on: (i) chlorophyll fluorescence emerging from the thylakoid membrane, (ii) a CFP marker embedded in the envelope, and (iii) calculations from serial block‐face scanning electron microscopy (SBFSEM). The obtained data were corroborated by comparing wild‐type data with two mutant lines affected in the plastid division machinery known to produce small and large mesophyll chloroplasts, respectively. Furthermore, we also determined the volume of the much smaller guard cell plastids. Interestingly, their volume is not governed by the same components of the division machinery which defines mesophyll plastid size. Based on our three approaches, the average volume of a mature Col‐0 wild‐type mesophyll chloroplasts is 93 μm 3 . Wild‐type guard cell plastids are approximately 18 μm 3 . Lastly, our comparative analysis shows that the chlorophyll fluorescence analysis can accurately determine chloroplast volumes, providing an important tool to research groups without access to transgenic marker lines expressing genetically encoded fluorescence proteins or costly SBFSEM equipment.

Knoblauch, Jan↗

High-Performance, Radiation-Hardened Electronics for Space Environments

The Radiation Hardened Electronics for Space Environments (RHESE) project endeavors to advance the current state-of-the-art in high-performance, radiation-hardened electronics and processors, ensuring successful performance of space systems required to operate within extreme radiation and temperature environments. Because RHESE is a project within the Exploration Technology Development Program (ETDP), RHESE's primary customers will be the human and robotic missions being developed by NASA's Exploration Systems Mission Directorate (ESMD) in partial fulfillment of the Vision for Space Exploration. Benefits are also anticipated for NASA's science missions to planetary and deep-space destinations. As a technology development effort, RHESE provides a broad-scoped, full spectrum of approaches to environmentally harden space electronics, including new materials, advanced design processes, reconfigurable hardware techniques, and software modeling of the radiation environment. The RHESE sub-project tasks are: SelfReconfigurable Electronics for Extreme Environments, Radiation Effects Predictive Modeling, Radiation Hardened Memory, Single Event Effects (SEE) Immune Reconfigurable Field Programmable Gate Array (FPGA) (SIRF), Radiation Hardening by Software, Radiation Hardened High Performance Processors (HPP), Reconfigurable Computing, Low Temperature Tolerant MEMS by Design, and Silicon-Germanium (SiGe) Integrated Electronics for Extreme Environments. These nine sub-project tasks are managed by technical leads as located across five different NASA field centers, including Ames Research Center, Goddard Space Flight Center, the Jet Propulsion Laboratory, Langley Research Center, and Marshall Space Flight Center. The overall RHESE integrated project management responsibility resides with NASA's Marshall Space Flight Center (MSFC). Initial technology development emphasis within RHESE focuses on the hardening of Field Programmable Gate Arrays (FPGA)s and Field Programmable Analog Arrays (FPAA)s for use in reconfigurable architectures. As these component/chip level technologies mature, the RHESE project emphasis shifts to focus on efforts encompassing total processor hardening techniques and board-level electronic reconfiguration techniques featuring spare and interface modularity. This phased approach to distributing emphasis between technology developments provides hardened FPGA/FPAAs for early mission infusion, then migrates to hardened, board-level, high speed processors with associated memory elements and high density storage for the longer duration missions encountered for Lunar Outpost and Mars Exploration occurring later in the Constellation schedule.

Keys, Andrew S.↗

NASA Human Spaceflight Scenarios - Do All Our Models Still Say No?

Historically, NASA human spaceflight planning has included healthy doses of life cycle cost analysis. Planners put projects and their cost estimates in a budget context. Estimated costs became expected budgets. Regardless, real budgets rarely matched expectations. So plans would come and go as NASA canceled projects. New projects would arise and the cycle would begin again. Repeatedly, NASA schedule and performance ambitions come up against costs growing at double-digit rates while budgets barely rise a couple of percent a year. Significant skepticism greets proposed NASA programs at birth, as cost estimates for new projects are traditionally very high, and worse, far off the mark for those carried forward. In this environment the current "capability driven framework" for NASA human spaceflight evolved, where long term life cycle cost analysis are even viewed as possibly counter-productive. Here, a space exploration project, for example the Space Launch System, focuses on immediate goals. A life cycle is that of a project, not a program, and for only that span of time to a near term milestone like a first test launch. Unfortunately, attempting to avoid some pitfalls in long-term life cycle cost analysis breeds others. Government audits have noted that limiting the scope of cost analysis "does not provide the transparency necessary to assess long-term affordability" making it difficult to understand if NASA "is progressing in a cost-effective and affordable manner." Even in this short-term framework, NASA realizes the importance of long-term considerations, that it must "maximize the efficiency and sustainability of the Exploration Systems development programs", that this is "critical to free resources for re-investment...such as other required deep space exploration capabilities." Assuming the value of long-term life cycle cost analysis, where due diligence meets reconnaissance, and accepting past shortcomings, the work here approaches life cycle cost analysis for human spaceflight differently. 1) If costs have traditionally been so high that adding them up is discouraging, are there any new facts on the ground offering paths to significantly lower costs? 2) If NASA's spaceflight budget and process is an over-arching constraint, with its planning limitations favoring short-term outlooks, is there a way to step outside the budget box? 3) If life cycle answers have historically been too uncertain to be useful, is there a process where stakeholders gain valuable insights merely from emphasizing a common understanding around questions? We analyze the potential life cycle cost of assorted NASA human spaceflight architectures - an architecture as a sum of individual systems, working together. With the prior questions of high costs, limited budgets and uncertainties in mind, public private partnerships are central in these architectures. The cost data for current commercial public private partnerships is encouraging, as are cost estimates for future partnership approaches beyond low Earth orbit. Private capital, directly or indirectly, an ingredient of public private partnerships, may be a significant factor in finding a path around the limits of the NASA spaceflight budget. Also, understanding and reviewing the pros, cons and uncertainties of assorted architectures can assist in developing a common understanding around key questions as important if not more so than the numbers and answers. Lastly, a scenario planning technique is briefly explored that can mature a common understanding about the agencies situation at hand and how diverse stakeholders can go forward together. Scenario planning, rather than focusing on answers, places emphasis on stakeholders developing a common understanding about the future. Putting aside costs, this is especially true of questions about sustainability and growth, results, benefits and expectations. While efficiency exercises or analysis look to reduce resources in one place to apply them elsewhere, moving around slices in a pie, scenario planning can get at the heart of the matter, growing the pie, transforming it, and making the pieces relevant. Especially important is the question of sustainability for different scenarios in the broad sense of the word - not just the narrow ability to survive or continue, but also the ability to adapt, prosper and grow.

space systems life cycle costs↗

File-Based One-Way BISON Coupling Through VERA: User's Manual

Activities to incorporate fuel performance capabilities into the Virtual Environment for Reactor Applications (VERA) are receiving increasing attention [1–6]. The multiphysics emphasis is expanding as the neutronics (MPACT) and thermal-hydraulics (CTF) packages are becoming more mature. Capturing the finer details of fuel phenomena (swelling, densification, relocation, gap closure, etc.) is the natural next step in the VERA development process since these phenomena are currently not directly taken into account. While several codes could be used to accomplish this, the BISON fuel performance code [8,9] being developed by the Idaho National Laboratory (INL) is the focus of ongoing work in the Consortium for Advanced Simulation of Light Water Reactors (CASL). Built on INL’s MOOSE framework [10], BISON uses the finite element method for geometric representation and a Jacobian-free Newton-Krylov (JFNK) scheme to solve systems of partial differential equations for various fuel characteristic relationships. There are several modes of operation in BISON, but, this work uses a 2D azimuthally symmetric (R-Z) smeared-pellet model. This manual is intended to cover (1) the procedure pertaining to the standalone BISON one-way coupling from VERA and (2) the procedure to generate BISON fuel temperature tables that VERA can use.

21 SPECIFIC NUCLEAR REACTORS AND ASSOCIATED PLANTS↗