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DOE OSTI2025

Quantum-enhanced detection of viral cDNA via luminescence resonance energy transfer using upconversion and gold nanoparticles

Abstract The COVID-19 pandemic has profoundly impacted global economies and healthcare systems, revealing critical vulnerabilities in both. In response, our study introduces a sensitive and highly specific detection method for cDNA, leveraging Luminescence Resonance Energy Transfer (LRET) between upconversion nanoparticles (UCNPs) and gold nanoparticles (AuNPs), and achieves a detection limit of 242 fM for SARS-CoV-2 cDNA. This innovative sensing platform utilizes UCNPs conjugated with one primer and AuNPs with another, targeting the 5′ and 3′ ends of the SARS-CoV-2 cDNA, respectively, enabling precise differentiation of mismatched cDNA sequences and significantly improving detection specificity. Through rigorous experimental analysis, we established a quenching efficiency range from 10.4 % to 73.6 %, with an optimal midpoint of 42 %, thereby demonstrating the superior sensitivity of our method. Our work uses SARS-CoV-2 cDNA as a model system to demonstrate the potential of our LRET-based detection method. This proof-of-concept study highlights the adaptability of our platform for future diagnostic applications. Instrumental validation confirms the synthesis and formation of AuNPs, addressing the need for experimental verification of the preparation of nanomaterial. Our comparative analysis with existing SARS-CoV-2 detection methods revealed that our approach provides a low detection limit and high specificity for target cDNA sequences, underscoring its potential for targeted COVID-19 diagnostics. This study demonstrates the superior sensitivity and adaptability of using UCNPs and AuNPs for cDNA detection, offering significant advances in rapid, accessible diagnostic technologies. Our method, characterized by its low detection limit and high precision, represents a critical step forward in developing next-generation biosensors for managing current and future viral outbreaks. By adjusting primer sequences, this platform can be tailored to detect other pathogens, contributing to the enhancement of global healthcare responsiveness and infectious disease control.

Esmaeili, Shahriar [Institute for Quantum Science ↗

DOE OSTI2020

Radar Motion Measurements and Synthetic Aperture Radar Image Geolocation Accuracy

Once a Synthetic Aperture Radar (SAR) image is formed, the natural question then is, "Where is this image?" and/or "Where exactly is this feature displayed in the image?" Thus, geolocation is an important exploitation of the SAR image. Since SAR measures relative location to its own position, it is crucial to understand how the radars position and motion imp acts the ability to geolocate a feature in the SAR image. Furthermore, accuracy and precision of navigation aids like GPS directly impact the goodness of the geolocation solution. These relationships are developed and discussed.

58 GEOSCIENCES↗

DOE OSTI2020

Drop Analysis of the Advanced Test Reactor Fresh Fuel Shipping Container with Heavier Low-Enriched Uranium Fuel Contents

The Advanced Test Reactor Fresh Fuel Shipping Container (ATR FFSC) is a rectangular stainless steel container used for shipping radioactive material. The container is described in the ATR FFSC Safety Analysis Report (SAR). Per the ATR FFSC SAR, the ATR FFSC is designated a Type AF-96 packaging per the definition of 10 CFR §71.4, and was originally designed to transport high enriched uranium (HEU) reactor fuel elements for the Advanced Test Reactor (ATR), the Advanced Test Reactor Critical (ATRC) facility, the Massachusetts Institute of Technology Reactor (MITR), and the University of Missouri Research Reactor (MURR). The Department of Energy, National Nuclear Security Administration’s (NNSA), Office of Material Management and Minimization (M3) is working with the Idaho National Laboratory (INL) to develop and qualify new low enriched uranium (LEU) fuels and technologies for use in the ATR, ATRC, MITR, and MURR reactors. The LEU fuel elements will weigh significantly more than the current HEU designs and, combined with their associated Fuel Handling Enclosures for packaging, some configurations will exceed the 50 lbf used in the ATR FFSC qualifying drop tests. There are LEU versions of MITR, MURR, and ATR fuel elements. However, for this evaluation, drop analysis of the ATR FFSC with only the heavier ATR Low Enrichment (LOWE) fuel element is considered in this evaluation because the LOWE fuel element is the heaviest of the considered LEU fuel elements. The ATR HEU fuel element and the ATR LOWE fuel element are identical in every design aspect except for the fuel meat inside the 19 fuel plates. The LEU fuel meats are made using a U-10Mo high-density foil rather than uranium dispersed in aluminum in the HEU fuel elements. The high density of the uranium in the LEU fuel meat increases the LOWE fuel element weight to just under 44 lbf (versus the 22.1 lbf weight of the tested ATR HEU fuel element). ATR fuel elements are placed in a thin-gauge aluminum weldment called a "Fuel Handling Enclosure" during packaging. The Fuel Handling Enclosure is used to cover and protect the element during loading and unloading operations. The ATR Fuel Handling Enclosure weighs about 15 lbf per the drawings in the ATR FFSC SAR and the weight is accounted for in this evaluation. Transporting the heavier LEU fuel elements require evaluation of two issues. The first is the effect of the increased mass of the LEU fuel elements on the survivability of the ATR FFSC package following the requisite drop qualifications. The second is the effect of the increased mass of the fuel plates on the fuel element during the same drops. The ATR FFSC containing an ATR HEU fuel element in an ATR Fuel Handling Enclosure was physically dropped multiple times to qualify the container as a Type AF-96 package. The ATR FFSC SAR describes the drop tests performed with an actual ATR HEU fuel element weighing 22.1 lbf contained in a 14.3 lbf Fuel Handling Enclosure for a total payload of 36.4 lbf. Those drop tests showed that the ATR FFSC maintained containment of the ATR HEU fuel element and the fuel element was not significantly damaged. (Containment herein is not defined as a leak tight but is retention of the radioactive contents.) The purpose of the evaluation is to analytically show that, for a similar set of tests, the ATR FFSC maintains containment of the heavier ATR LOWE fuel element and to assess the damage to the fuel element during the drops. The approach was to create finite element analysis (FEA) models that produce the same results as the physical drops. Those models were then used as the benchmarks for the follow-on analyses using the heavier contents. FEA models of the drops of ATR FFSC using up to a 115 lbf fuel element were run and evaluated. Likewise, drops of a LOWE fuel element weighing 44 lbf in the ATR FFSC were run and evaluated. It is important to note that this report was done at the quality level necessary to be included in a nuclear facility safety basis. However, it is not the intent of this report to conclude the suitability of the ATR FFSC for transporting the heavier payloads. This report only describes the results of the FEA as related to the required drop scenarios. Incorporation of the FEA into the safety basis will be evaluated by the ATR FFSC design authority. The physical drop tests of the HEU fuel element and FEA drop analysis for the LOWE fuel element showed noteworthy damage to the fuel plates. An aluminum protective block was conceived to mitigate the damage. The concept requires the blocks to be placed in the fuel element between the end boxes and fuel plates. Additional FEA drop analyses were performed using the protective block. The addition of the blocks is primarily intended to mitigate the damage to the LOWE fuel element fuel plates. However, FEA drop analyses of the ATR HEU fuel element with the blocks were also performed and included for information.

42 ENGINEERING↗

DOE OSTI2021

Viral Fate and Transport for COVID-19 - NVBL

The NVBL Viral Fate and Transport Team includes researchers from eleven DOE national laboratories and is utilizing unique experimental facilities combined with physics-based and data-driven modeling and simulation to study the transmission, transport, and fate of SARSCoV-2. The team was focused on understanding and ultimately predicting SARS-CoV-2 viability in varied environments with the goal of rapidly informing strategies that guide the nation’s resumption of normal activities. The primary goals of this project include prioritizing administrative and engineering controls that reduce the risk of SARS-CoV-2 transmission within an enclosed environment; identifying the chemical and physical properties that influence binding of SARS-CoV-2 to common surfaces; and understanding the contribution of environmental reservoirs and conditions on transmission and resurgence of SARS-CoV-2.

59 BASIC BIOLOGICAL SCIENCES↗

DOE OSTI2021

Viral Fate and Transport for COVID-19

54 ENVIRONMENTAL SCIENCES↗

DOE OSTI2022

Synthetic Aperture Radar Image Geolocation Using Fiducial Images

Synthetic Aperture Radar (SAR) creates imagery of the earth’s surface from airborne or spaceborne radar platforms. However, the nature of any radar is to geolocate its echo data, i.e., SAR images, relative to its own measured radar location. Acceptable accuracy and precision of such geolocation can be quite difficult to achieve, and is limited by any number of parameters. However, databases of geolocated earth imagery do exist, often using other imaging modalities, with Google Earth being one such example. These can often be much more accurate than what might be achievable by the radar itself. Consequently, SAR images may be aligned to some higher accuracy database, thereby improving the geolocation of features in the SAR image. Examples offer anecdotal evidence of the viability of such an approach.

47 OTHER INSTRUMENTATION↗

DOE OSTI2023

Host genetics and gut microbiota composition: Baseline gut microbiota composition as a possible prognostic factor for the severity of COVID-19 in patients with familial Mediterranean fever disease

It is known that the gut microbiome of a healthy person affects the process of COVID-19 after getting infected with SARS-CoV-2 virus. It is also believed that colchicine can alleviate the severity of COVID-19. Current investigations aimed to evaluate the associations between the baseline gut microbiota composition of healthy and Familial Mediterranean fever (FMF) - carrier Armenian men populations, and the severity of the COVID-19 disease after their infection with the SARS-CoV-2. The study has a purpose of answering three core questions: i. Do the characteristics of gut microbiome of Armenians affect the course of COVID-19 severity? ii. How does the COVID-19 disease course on go for FMF patients who have been taking colchicine as a medication over the years after getting infected with SARS-CoV-2? iii. Is there an initial gut micribiota structure pattern for non-FMF and FMF patients in the cases when COVID-19 appears in mild form? The gut microbiota composition in non-FMF and FMF patients before the first infection (mild and moderate course of COVID-19) was considered. COVID-19 was diagnosed by SARS-CoV-2 nucleic acid RT-PCR in nasopharyngeal swab and/or sputum. The number of patients with male FMF with mild COVID-19 was approximately two times higher than that of non-FMF male subjects with COVID-19. In addition, an association of COVID-19 disease severity with the baseline gut Prevotella, Clostridium hiranonis, Eubacterium biforme, Veillonellaceae, Coprococcus, and Blautia diversities in the non-FMF and FMF populations were revealed by us, which can be used as risk/prognostic factor for the severity of COVID-19.

60 APPLIED LIFE SCIENCES↗

NASA NTRS1978

SAR/LANDSAT image registration study

The author has identified the following significant results. Temporal registration of synthetic aperture radar data with LANDSAT-MSS data is both feasible (from a technical standpoint) and useful (from an information-content viewpoint). The greatest difficulty in registering aircraft SAR data to corrected LANDSAT-MSS data is control-point location. The differences in SAR and MSS data impact the selection of features that will serve as a good control points. The SAR and MSS data are unsuitable for automatic computer correlation of digital control-point data. The gray-level data can not be compared by the computer because of the different response characteristics of the MSS and SAR images.

Murphrey, S. W.↗

NASA NTRS1978

The comparison between the synthetic aperture radar imageries and the surface truth of ocean waves

Ocean waves measured offshore of Marineland, Florida, by the synthetic aperture radar (SAR) are compared with the surface truth data. The Fourier transform of SAR imageries are taken and the corrections of the wave directions and wave lengths due to the relative velocities between SAR and waves are considered. Favorable comparisons are obtained for the peak frequencies, wave directions, and directional distributions. However, the one-dimensional SAR spectra are quite different from the surface truth wave height spectra.

Hsiao, S. V.↗

NASA NTRS1979

SEASAT-A synthetic aperture radar performance

The SEASAT-A satellite synthetic aperture radar (SAR) is presented, and its performance since it began operation in July 1978, is examined. The imaging radar system, the first to be designed as an orbital scientific instrument, was intended to generate continuous imagery over a 100-km swath at 25-m resolution from an altitude of 800 km. SAR image quality is measured in terms of resolution, the range of detectable radar backscatter, and the contrast ratio, each of which is affected by antenna, sensor, data link, and recording/processor subsystem parameters. Microdensitometer scans of output image film of actual SEASAT-A SAR data reveal a range resolution of less than 25 m, an azimuth resolution of approximately 40 m, a noise equivalent dynamic range of from 9.6 to -21 + or - 5 dB, and an image contrast ratio of 7.5 dB. SEASAT-A SAR performance is concluded to have confirmed the utility of spaceborne radar sensing.

Jordan, R. L.↗

NASA NTRS1980

Seasat orbital radar imagery for geologic mapping - Tennessee-Kentucky-Virginia

The purpose of the reported study is to analyze Seasat SAR imagery of a heavily vegetated mountainous land surface and to determine the potential of this microwave imaging system for geologic mapping. It is found that geologic mapping using orbital Seasat SAR imagery is feasible in the Appalachian Valley and Ridge province, where the radar system is highly sensitive to change of surface slope. Image tones and textures correlate with distinctive topography, from which generalized lithologic and structural interpretations are derived. Major and minor linear topographic features are easily mapped from the SAR images. The SAR sensor suppresses subdued geomorphic lineaments that strike parallel with or near to the radar look direction. This deficiency is partly compensated by the dual directions of radar illumination obtainable from the Seasat imaging system.

Ford, J. P.↗

NASA NTRS1980

Analysis of urban area land cover using SEASAT Synthetic Aperture Radar data

Digitally processed SEASAT synthetic aperture raar (SAR) imagery of the Denver, Colorado urban area was examined to explore the potential of SAR data for mapping urban land cover and the compatability of SAR derived land cover classes with the United States Geological Survey classification system. The imagery is examined at three different scales to determine the effect of image enlargement on accuracy and level of detail extractable. At each scale the value of employing a simplistic preprocessing smoothing algorithm to improve image interpretation is addressed. A visual interpretation approach and an automated machine/visual approach are employed to evaluate the feasibility of producing a semiautomated land cover classification from SAR data. Confusion matrices of omission and commission errors are employed to define classification accuracies for each interpretation approach and image scale.

Henderson, F. M.↗

NASA NTRS1982

FIREX mission requirements document for nonrenewable resources

The proposed mission requirements and a proposed experimental program for satellite synthetic aperture radar (SAR) system named FIREX (Free-Flying Imaging Radar Experiment) for nonrenewable resources is described. The recommended spacecraft minimum SAR system is a C-band imager operating in four modes: (1) low look angle HH-polarized; (2) intermediate look angle, HH-polarized; (3) intermediate look angle, IIV-polarized; and (4) high look angle HH-polarized. This SAR system is complementary to other future spaceborne imagers such as the Thematic Mapper on LANDSAT-D. A near term aircraft SAR based research program is outlined which addresses specific mission design issues such as preferred incidence angles or polarizations for geologic targets of interest.

Dixon, T.↗

NASA NTRS1982

The observation of ocean surface phenomena using imagery from the Seasat synthetic aperture radar - An assessment

The principles governing synthetic aperture radar (SAR) and its use on the Seasat spacecraft are reviewed. The way in which wind stress, surface currents, long gravity waves, and surface films modulate the scattering properties of resonant (approximately 30-cm-wavelength) waves is discussed, with particular emphasis placed on the mechanisms that could produce images of long gravity waves. Doppler effects by ocean motion are also described. Measurements of long (wavelength more than about 100 m) gravity waves made using Seasat SAR imagery are compared with surface measurements during several experiments. Combining these results, it is found that dominant wavelength and direction are measured by Seasat SAR within + or - 12% and + or - 15 deg, respectively. It is noted, however, that ocean waves are not always visible in SAR images, and detection criteria are discussed in terms of wave height, length, and direction.

Vesecky, J. F.↗

NASA NTRS1981

Radar imagery for forest cover mapping

Dual-polarized, X-band Synthetic Aperture Radar (SAR) imagery was obtained from an altitude of 60,000 feet over a test area near Camden, SC on June 30, 1980. The objective of this study was to determine, qualitatively, the value of the SAR imagery for identifying various forest cover types. In analyzing the HH and HV polarization images, particular attention was given to the tonal and textural characteristics of the cover types involved. The analysis of the dual-polarized SAR imagery has shown that certain forest cover features are more easily identified in one polarization than the other, while some features look very similar in both polarizations. In general, the results for this data set have shown that the overall tonal contrast between features was greater on the HH image. Neither polarization was consistently better for identifying the various forest cover types examined. These results suggest the usefulness of a dual-polarized SAR system for mapping forest cover.

Knowlton, D. J.↗

NASA NTRS1983

Amplitude calibration of spaceborne synthetic aperture radars

Problems encountered during attempts to calibrate SAR imagery, recent successful experiments conducted with SEASAT SAR data, and a proposed program for the calibration and validation of the radar imagery from the forthcoming SIR-B SAR are discussed. The SEASAT SAR data for 10 passes over Death valley, California, were processed with a modified digital correlator. The procedure included a preliminary screening of the data to check for raw data saturation, compensation of waveforms and estimation of the amplitude of the pilot tone. All data was normalized to this pilot tone signal to reduce the effects of variable gains in the data links and ground receivers. The digital correlation algorithm generated image data. Evaluation of 6 passes results in a maximum pass to pass gain variation of only 1.1 dB and a standard deviation amongst the passes of 0.35 dB.

Held, D. N.↗

NASA NTRS1981

Amplitude calibration of synthetic aperture radars - The effects of nonlinearities

Nonlinearities within a synthetic aperture radar (SAR) present significant obstacles to the calibration of the output imagery. The problem of calibrating a SAR is considerably more involved than that of calibrating a real aperture radar (RAR) or scatterometer, since the SAR relies heavily on the principle of superposition, which fails in nonlinear systems. It is shown in this paper that non-linearities can distort SAR imagery to such an extent that two areas of equal backscatter on the ground can be imaged to have significantly different intensities in the image.

Held, D. N.↗

NASA NTRS1983

Use of Seasat synthetic aperture radar and Landsat multispectral scanner subsystem data for Alaskan glaciology studies

Three Seasat synthetic aperture radar (SAR) and three Landsat multispectral scanner subsystem (MSS) scenes of three areas of Alaska were analyzed for hydrological information. The areas were: the Dease Inlet in northern Alaska and its oriented or thaw lakes, the Ruth and Tokositna valley glaciers in south central Alaska, and the Malaspina piedmont glacier on Alaska's southern coast. Results for the first area showed that the location and identification of some older remnant lake basins were more easily determined in the registered data using an MSS/SAR overlay than in either SAR or MSS data alone. Separately, both SAR and MSS data were useful for determination of surging glaciers based on their distinctive medial moraines, and Landsat data were useful for locating the glacier firn zone. For the Malaspina Glacier scenes, the SAR data were useful for locating heavily crevassed ice beneath glacial debris, and Landsat provided data concerning the extent of the debris overlying the glacier.

Hall, D. K.↗