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At least 1,621 records · Page 90

Responses of women to orthostatic and exercise stresses

The results are presented from a special physiological study of women at the Johnson Space Center in 1976 to 1977. Its purpose was to establish a large (98 subjects) database from normal working women. The data sets are medical historical, clinical, anthropometric, and stress response statistics useful for establishing medical criteria for selecting women astronauts. Stressors were lower body negative pressure and static standing (both orthostatic) and treadmill exercise (ergometric). Data shown are original individual values with analyses and subsets, and statistical summaries and correlations relating to human responses to microgravity. Similarities appear between the characteristics of women in this study and those of women astronauts currently flying in Shuttle crews.

Hoffler, G. W.↗

Simulation of Tropical Biomass Burning

The research objectives that were achieved during the course of our studies include the following: (1) Over the last few years, a model has been developed in the Atmospheric Chemistry and Dynamics Branch at Ames Research Center in collaboration with the Physics Department at San Jose State University. It is referred to as the Global/Regional Atmospheric Chemistry Event Simulator (GRACES). Currently, the GRACES model system combines an atmospheric chemistry and transport model, and a regional mesoscale meteorological model. Therefore this system is suitable for simulating the conditions observed by the tropical observation missions, such as the Pacific Exploratory Mission in the 'Tropics (PEM-Tropics), Study of Ozone and Nitrogen oxides Experiment (SONEX), and other periods. Specifically, the research carried out included the evaluation of the behavior of several components of the MM5 (I.e., Meteorological Model 5, version 2) and the GRACES combined modeling system. We initiated research on (a) the ability of the MM5 model to assimilate downward vertical velocities at least as high as the analyses, (b) the ability of the Graces model to incorporate the vertical velocities from MM5, and (c) other factors related to transport patterns required to transport CO in the observed manner. We carried out improved calculations of the transport of tracers for both NASA airborne missions, SONEX and PEM-Tropics. We also made improved source strength estimates fopr isoprene dust, and similar emissions from the Earths surface. This required the use of newly available databases on the Earth's surface and vegetation. We completed atmospheric chemistry simulations of radicals and nitrogen oxide species. We have greatly improved the handling of cumulonimnbus convection by modifing an existing scheme.

Hamill, Patrick↗

Microcomputer Software

MicroRim, Inc.'s Microrim is a deviation of a database developed under NASA funding and used by NASA to store data required for analyzing the heat shield tiles on the Space Shuttle Orbiter. As a management system for microcomputers, it offers mainframe sophistication and allows for sorting, storing and data retrieval for various applications. The program is convertible, and easily utilized by nontechnical personnel. RIM (Relational Information Management) is currently used for structural analysis and design data management, etc. by a variety of businesses and universities.

Source record↗

Global Properties of Local Star Forming Galaxies (ADP 2000)

We performed an archival study of the Hopkins Ultraviolet Telescope (HUT) Astro-2 database. Nineteen spectra of star-forming regions and starburst galaxies were retrieved, reprocessed, and analyzed. The spectra cover the wavelength region 912- 1800 A, providing access to the domain of peak luminosity from a young stellar population. We created an atlas of galaxy spectra documenting the continuum and line properties with an emphasis on the relatively unexplored spectral region below 1200 A. The dust obscuration law was derived from a comparison of the HUT spectra with synthetic population models. The law is similar to the commonly adopted starburst reddening curve at longer wavelengths and approaches the Milky Way law near the Lyman break. A simple power-law parameterization is given, which allows users to express the reddening law in terms of the stellar or nebular color excess at ultraviolet or optical wavelengths. We studied the effect of time-dependent dust obscuration on synthetic ultraviolet line profiles of a young stellar population. If the youngest and most massive stars are more obscured than the older, less massive stars, the C IV 1550 and other stellar wind lines are significantly diluted with respect to a simple foreground screen model for the dust. We propose to use stellar wind lines as a probe of the dust-obscuration model instead of the previously employed nebular emission lines. Since purely stellar diagnostics are utilized, uncertain assumptions on the nebular properties are unnecessary. Photoionization models demonstrate that the C IV 1550 emission is typically dominated by stellar winds and nebular contamination is negligible. A first comparison with the galaxy sample observed with the Hopkins Ultraviolet Telescope favors a dust geometry affecting ionizing and nonionizing stars equally. We point out the need for higher quality data for a more rigorous comparison. The Hubble Space Telescope is capable of obtaining such data in the future.

Leitherer, Claus↗

A calmodulin binding protein from Arabidopsis is induced by ethylene and contains a DNA-binding motif

Calmodulin (CaM), a key calcium sensor in all eukaryotes, regulates diverse cellular processes by interacting with other proteins. To isolate CaM binding proteins involved in ethylene signal transduction, we screened an expression library prepared from ethylene-treated Arabidopsis seedlings with 35S-labeled CaM. A cDNA clone, EICBP (Ethylene-Induced CaM Binding Protein), encoding a protein that interacts with activated CaM was isolated in this screening. The CaM binding domain in EICBP was mapped to the C-terminus of the protein. These results indicate that calcium, through CaM, could regulate the activity of EICBP. The EICBP is expressed in different tissues and its expression in seedlings is induced by ethylene. The EICBP contains, in addition to a CaM binding domain, several features that are typical of transcription factors. These include a DNA-binding domain at the N terminus, an acidic region at the C terminus, and nuclear localization signals. In database searches a partial cDNA (CG-1) encoding a DNA-binding motif from parsley and an ethylene up-regulated partial cDNA from tomato (ER66) showed significant similarity to EICBP. In addition, five hypothetical proteins in the Arabidopsis genome also showed a very high sequence similarity with EICBP, indicating that there are several EICBP-related proteins in Arabidopsis. The structural features of EICBP are conserved in all EICBP-related proteins in Arabidopsis, suggesting that they may constitute a new family of DNA binding proteins and are likely to be involved in modulating gene expression in the presence of ethylene.

Non-NASA Center↗

Characterization of bioelectric potentials

Method and system for recognizing and characterizing bioelectric potential or electromyographic (EMG) signals associated with at least one of a coarse gesture and a fine gesture that is performed by a person, and use of the bioelectric potentials to enter data and/or commands into an electrical and/or mechanical instrument. As a gesture is performed, bioelectric signals that accompany the gesture are subjected to statistical averaging, within selected time intervals. Hidden Markov model analysis is applied to identify hidden, gesture-related states that are present. A metric is used to compare signals produced by a volitional gesture (not yet identified) with corresponding signals associated with each of a set of reference gestures, and the reference gesture that is closest to the volitional gesture is identified. Signals representing the volitional gesture are analyzed and compared with a database of reference gestures to determine if the volitional gesture is likely to be one of the reference gestures. Electronic and/or mechanical commands needed to carry out the gesture may be implemented at an interface to control an instrument. Applications include control of an aircraft, entry of data from a keyboard or other data entry device, and entry of data and commands in extreme environments that interfere with accurate entry.

Jorgensen, Charles C.↗

Inferring Cirrus Size Distributions Through Satellite Remote Sensing and Microphysical Databases

Since cirrus clouds have a substantial influence on the global energy balance that depends on their microphysical properties, climate models should strive to realistically characterize the cirrus ice particle size distribution (PSD), at least in a climatological sense. To date, the airborne in situ measurements of the cirrus PSD have contained large uncertainties due to errors in measuring small ice crystals (D<60 m). This paper presents a method to remotely estimate the concentration of the small ice crystals relative to the larger ones using the 11- and 12- m channels aboard several satellites. By understanding the underlying physics producing the emissivity difference between these channels, this emissivity difference can be used to infer the relative concentration of small ice crystals. This is facilitated by enlisting temperature-dependent characterizations of the PSD (i.e., PSD schemes) based on in situ measurements. An average cirrus emissivity relationship between 12 and 11 m is developed here using the Moderate Resolution Imaging Spectroradiometer (MODIS) satellite instrument and is used to retrieve the PSD based on six different PSD schemes. The PSDs from the measurement-based PSD schemes are compared with corresponding retrieved PSDs to evaluate differences in small ice crystal concentrations. The retrieved PSDs generally had lower concentrations of small ice particles, with total number concentration independent of temperature. In addition, the temperature dependence of the PSD effective diameter De and fall speed Vf for these retrieved PSD schemes exhibited less variability relative to the unmodified PSD schemes. The reduced variability in the retrieved De and Vf was attributed to the lower concentrations of small ice crystals in the retrieved PSD.

Mitchell, David↗

Informing the Space Launch System Booster Separation Initial CFD Run Matrix with Observed Parametric Sensitivity

It currently requires significant computational cost to simulate the flow physics of the booster separation event on the Space Launch System. This comes from the large parametric space in which the event occurs, as pre-separation flight conditions and separated booster core-relative trajectories can vary. Functionally removing the risk of core-booster collision mandates careful assessment of the fluid dynamics in terms of several trajectory parameters. However, simulating the entire trajectory envelope is computationally intractable given the high parametric dimension. In order to reduce the uncertainty in the resulting low-parametric-resolution aerodynamic booster separation database, a data-driven approach was developed to select which breakpoints should be studied by simulations and experiments and which should be relegated to a regression-based interpolation procedure. This technique works by simulating cases where the flow physics are most sensitive to changes in the parameters and leaving the less parametrically sensitive regions for interpolation. The result is a booster separation run matrix whose computational cost is comparable to that of previous database generations but has lower interpolation errors.

SLS↗

Informing the Space Launch System Booster Separation Initial CFD Run Matrix with Observed Parametric Sensitivity

It currently requires significant computational cost to simulate the flow physics of the booster separation event on the Space Launch System. This comes from the large parametric space in which the event occurs, as pre-separation flight conditions and separated booster core-relative trajectories can vary. Functionally removing the risk of core-booster collision mandates careful assessment of the fluid dynamics in terms of several trajectory parameters. However, simulating the entire trajectory envelope is computationally intractable given the high parametric dimension. In order to reduce the uncertainty in the resulting low-parametric-resolution aerodynamic booster separation database, a data-driven approach was developed to select which breakpoints should be studied by simulations and experiments and which should be relegated to a regression-based interpolation procedure. This technique works by simulating cases where the flow physics are most sensitive to changes in the parameters and leaving the less parametrically sensitive regions for interpolation. The result is a booster separation run matrix whose computational cost is comparable to that of previous database generations but has lower interpolation errors.

SLS↗

Decision Analysis of Dynamic Spectrum Access Rules

A current trend in spectrum regulation is to incorporate spectrum sharing through the design of spectrum access rules that support Dynamic Spectrum Access (DSA). This paper develops a decision-theoretic framework for regulators to assess the impacts of different decision rules on both primary and secondary operators. We analyze access rules based on sensing and exclusion areas, which in practice can be enforced through geolocation databases. Our results show that receiver-only sensing provides insufficient protection for primary and co-existing secondary users and overall low social welfare. On the other hand, using sensing information between the transmitter and receiver of a communication link, provides dramatic increases in system performance. The performance of using these link end points is relatively close to that of using many cooperative sensing nodes associated to the same access point and large link exclusion areas. These results are useful to regulators and network developers in understanding in developing rules for future DSA regulation.

42 ENGINEERING↗

Integrated Analyses of Multiple Worldwide Aerosol Mass Spectrometer Datasets for Improved Understanding of Aerosol Sources and Processes and for Comparison with Global Models

The AMS is the only current instrument that provides real-time, quantitative, and size-resolved data on submicron non-refractory aerosol species with a time resolution of a few minutes or better. The AMS field data are multidimensional and massive, containing extremely rich information on aerosol chemistry, microphysics and dynamics—basic information that is required to evaluate and quantify the radiative climate forcing of atmospheric aerosols. The high time resolution of the AMS data also reveals details of aerosol dynamic variations that are vital to understanding the physico-chemical processes of atmospheric aerosols that govern aerosol properties relevant to the climate. There are two primary objectives of this 3-year project. Our first objective is to perform highly integrated analysis of dozens of AMS datasets acquired from various urban, forested, coastal, marine, mountain peak, and rural/remote locations around the world and synthesize and inter-compare results with a focus on the sources and the physico-chemical processes that govern aerosol properties relevant to aerosol climate forcing. Our second objective is to support our collaboration with global aerosol modelers, in which we will supply the size-resolved aerosol composition and temporal variation data (via a public web interface) and our analysis results for use in model testing and validation and for translation of the rich AMS database into model constraints that can improve climate forcing simulations. Several prominent global aerosol modelers have expressed enthusiastic support for this collaboration. The specific tasks that we propose to accomplish include 1) to develop, validate, and apply multivariate analysis techniques for improved characterization and source apportionment of organic aerosols; 2) to evaluate aerosol source regions and relative contributions based on back-trajectory integration (PSCF method); 3) to summarize and synthesize submicron aerosol information, including composition, concentration, size distribution and (inferred) shape and mixing state in various environments and their regional and seasonal variations within the context of regional and global modeling; and 4) to quantitatively evaluate important processes in various atmospheric environments and during different seasons, focusing on acid-catalyzed SOA formation, new particle growth, and photochemical processes of atmospheric organic aerosols (i.e., SOA production and POA oxidation). We will also examine the correlations and compile the ratios between important pairs of aerosol and gas phase species using region-specific and season-specific correlations and as a function of photochemical age and compare them with the ratios produced by various models. To enable our collaborations with the modelers, we will supply (via a public web interface) AMS data and our analysis results for use in model testing and validation and facilitate the use of the AMS information to constrain calculations of radiative forcing. Model output and AMS measurements and derived parameters will be compared with a focus on regional variability of model/measurement discrepancies and their causes. Finally we will share results, insights and data mining algorithms through peer-reviewed publications, presentations/tutorials at conferences/workshops, and web dissemination of analysis results and in-house developed software packages.

58 GEOSCIENCES↗

Surface albedo spatial variability in North America: Gridded data vs. local measurements

Considering the current booming interest for the large-scale deployment of bifacial photovoltaic modules, the solar industry now requires accurate estimates of broadband surface albedo at high spatial resolution. In this context, the present study evaluates the adequacy and performance over North America of two Moderate Resolution Imaging Spectroradiometer (MODIS) white-sky albedo products (at 500-m and 1-km resolution) and the National Solar Radiation Database (NSRDB) product at 4-km resolution. Two variations of the 500-m MODIS product are also considered: black-sky albedo and all-sky albedo. Albedo observations from 36 radiometric stations during 2011–2015 are analyzed while considering the apparent homogeneity of the surface characteristics over the 4x4 km NSRDB pixel in which they are located. Even at sites where the albedo around the station has been found “homogeneous” in the literature, marked differences are found between the daily observations and the gridded estimates at any spatial resolution. Furthermore, differences in seasonal behavior and between the three different albedo types also impact the accuracy of the albedo estimates, with overtones caused by local specificities and inhomogeneities. All this precludes the desirable evaluation of the local albedo at a specific site of relatively small size compared to its corresponding 4x4-km pixel if only the mean albedo over that pixel is known. Significant discrepancies are also found at snow-impacted sites, most importantly in the case of the NSRDB albedo estimates, which are typically much too high.

14 SOLAR ENERGY↗

Remote Sensing of CDOM, CDOM Spectral Slope, and Dissolved Organic Carbon in the Global Ocean

A Global Ocean Carbon Algorithm Database (GOCAD) has been developed from over 500 oceanographic field campaigns conducted worldwide over the past 30 years including in situ reflectances and coincident satellite imagery, multi- and hyperspectral Chromophoric Dissolved Organic Matter (CDOM) absorption coefficients from 245–715 nm, CDOM spectral slopes in eight visible and ultraviolet wavebands, dissolved and particulate organic carbon (DOC and POC, respectively), and inherent optical, physical, and biogeochemical properties. From field optical and radiometric data and satellite measurements, several semi-analytical, empirical, and machine learning algorithms for retrieving global DOC, CDOM, and CDOM slope were developed, optimized for global retrieval, and validated. Global climatologies of satellite-retrieved CDOM absorption coefficient and spectral slope based on the most robust of these algorithms lag seasonal patterns of phytoplankton biomass belying Case 1 assumptions, and track terrestrial runoff on ocean basin scales. Variability in satellite retrievals of CDOM absorption and spectral slope anomalies are tightly coupled to changes in atmospheric and oceanographic conditions associated with El Niño Southern Oscillation (ENSO), strongly covary with the multivariate ENSO index in a large region of the tropical Pacific, and provide insights into the potential evolution and feedbacks related to sea surface dissolved carbon in a warming climate. Further validation of the DOC algorithm developed here is warranted to better characterize its limitations, particularly in mid-ocean gyres and the southern oceans.

Dissolved organic carbon↗

Computerized System for Safety Verification of External Beam Radiation Therapy Planning

Purpose: To report an assessment of in-house software, Verifier, developed to improve efficacy and efficiency of the radiation therapy (RT) treatment planning process and quality control review (QCR). Methods and Materials: Radiation therapy plan parameters retrieved from our treatment planning database are used by automated tests to give 75 types of warnings, such as prescription and plan discrepancies. The software is continuously updated on the basis of new issues, ideas, and planning policies. Verifier was retrospectively assessed (2007-2015) by examining impact on treatment plan revisions, frequency of quality improvement incident reports of avoidable RT plan-related safety events, unaddressed issues, and staff efficiency. Results: Plan revisions for specific issues declined dramatically in response to implementation of corresponding Verifier tests. Between 2012 and 2015 our institution's total rate of plan revisions dropped from 18.0% to 11.2%. Between 2008 and 2015 specific tests were added to Verifier while the rate of corresponding avoidable safety events was reduced from 0.34% to 0.00% over the same period. Simulations suggest Verifier saves approximately 2 to 5 minutes per QCR. Conclusions: The decrease in quantifiable metrics of plan revisions and incident reports suggests automatic RT plan-checking software enhances patient safety and clinical efficiency. Although only modest time savings may be gained using Verifier for the QCR itself, the greater impact on efficiency is through avoiding late-stage plan modifications and improving documentation via automation. We encourage other institutions to consider working toward adding similar technologies to enhance their RT quality assurance programs.

62 RADIOLOGY AND NUCLEAR MEDICINE↗

How accurate are static polarizability predictions from density functional theory? An assessment over 132 species at equilibrium geometry

Static polarizabilities are the first response of the electron density to electric fields, and are therefore important for predicting intermolecular and molecule-field interactions. They also offer a global measure of the accuracy of the treatment of excited states by density functionals in a formally exact manner. We have developed a database of benchmark static polarizabilities for 132 small species at equilibrium geometry, using coupled cluster theory through triple excitations (extrapolated to the complete basis set limit), for the purpose of developing and assessing density functionals. The performance of 60 popular and recent functionals are also assessed, which indicates that double hybrid functionals perform the best, having RMS relative errors in the range of 2.5-3.8%. Many hybrid functionals also give quite reasonable estimates with 4-5% RMS relative error. A few meta-GGAs like mBEEF and MVS yield performance comparable to hybrids, indicating potential for improved excited state predictions relative to typical local functionals. Some recent functionals however are found to be prone to catastrophic failure (possibly as a consequence of overparameterization), indicating a need for caution in applying these.

74 ATOMIC AND MOLECULAR PHYSICS↗

AKARI NEAR-INFRARED SPECTROSCOPIC SURVEY FOR CO{sub 2} IN 18 COMETS

We conducted a spectroscopic survey of cometary volatiles with the Infrared Camera on board the Japanese infrared satellite AKARI in the wavelength range from 2.5 to 5 {mu}m. In our survey, 18 comets, including both the Oort cloud comets and the Jupiter-family comets, were observed in the period from 2008 June to 2010 January, most of which were observed at least twice. The prominent emission bands in the observed spectra are the fundamental vibrational bands of water (H{sub 2}O) at 2.7 {mu}m and carbon dioxide (CO{sub 2}) at 4.3 {mu}m. The fundamental vibrational band of carbon monoxide (CO) around 4.7 {mu}m and the broad emission feature, probably related to carbon-hydrogen-bearing molecules, can also be recognized around the 3.3-3.5-{mu}m region in some of the comets. With respect to H{sub 2}O, gas production rate ratios of CO{sub 2} have been derived in 17 comets, except for the comet 29P/Schwassmann-Wachmann 1. Our data set provides the largest homogeneous database of CO{sub 2}/H{sub 2}O production rate ratios in comets obtained so far. The CO{sub 2}/H{sub 2}O production rate ratios are considered to reflect the composition of cometary ice when a comet is observed at a heliocentric distance within {approx}2.5 AU, since H{sub 2}O ice fully sublimates there. The CO{sub 2}/H{sub 2}O ratio in cometary ice spans from several to {approx}30% among the comets observed at <2.5 AU (13 out of the 17 comets). Alternatively, the ratio of CO/CO{sub 2} in the comets seems to be smaller than unity based on our observations, although we only obtain upper limits for CO in most of the comets.

79 ASTRONOMY AND ASTROPHYSICS↗

The Human Phenotype Ontology project: linking molecular biology and disease through phenotype data

The Human Phenotype Ontology (HPO) project, available at http://www.human-phenotype-ontology.org, provides a structured, comprehensive and welldefined set of 10,088 classes (terms) describing human phenotypic abnormalities and 13,326 subclass relations between the HPO classes. In addition we have developed logical definitions for 46% of all HPO classes using terms from ontologies for anatomy, cell types, function, embryology, pathology and other domains. This allows interoperability with several resources, especially those containing phenotype information on model organisms such as mouse and zebrafish. Here we describe the updated HPO database, which provides annotations of 7,278 human hereditary syndromes listed in OMIM, Orphanet and DECIPHER to classes of the HPO. Various meta-attributes such as frequency, references and negations are associated with each annotation. Several large-scale projects worldwide utilize the HPO for describing phenotype information in their datasets. We have therefore generated equivalence mappings to other phenotype vocabularies such as LDDB, Orphanet, MedDRA, UMLS and phenoDB, allowing integration of existing datasets and interoperability with multiple biomedical resources. We have created various ways to access the HPO database content using flat files, a MySQL database, and Web-based tools. All data and documentation on the HPO project can be found online.

59 BASIC BIOLOGICAL SCIENCES↗

It's only natural: Plant respiration in unmanaged systems

Abstract Respiration plays a key role in the terrestrial carbon cycle and is a fundamental metabolic process in all plant tissues and cells. We review respiration from the perspective of plants that grow in their natural habitat and how it is influenced by wide-ranging elements at different scales, from metabolic substrate availability to shifts in climate. Decades of field-based measurements have honed our understanding of the biological and environmental controls on leaf, root, stem, and whole-organism respiration. Despite this effort, there remain gaps in our knowledge within and across species and ecosystems, especially in more challenging-to-measure tissues like roots. Recent databases of respiration rates and associated leaf traits from species representing diverse biomes, plant functional types, and regional climates have allowed for a wider-lens view at modeling this important CO2 flux. We also re-analyze published data sets to show that maximum leaf respiration rates (R max) in species from around the globe are related both to leaf economic traits and environmental variables (precipitation and air temperature), but that root respiration does not follow the same latitudinal trends previously published for leaf data. We encourage the ecophysiological community to continue to expand their study of plant respiration in tissues that are difficult to measure and at the whole plant and ecosystem levels to address outstanding questions in the field.

59 BASIC BIOLOGICAL SCIENCES↗