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At least 1,621 records · Page 90

Deficits in Sustained Attention and Changes in Dopaminergic Protein Levels Following Exposure to Proton Radiation are Related to Basal Dopaminergic Function

The current report assessed the effects of low-level proton irradiation in inbred adult male Fischer 344 and Lewis rats performing an analog of the human Psychomotor Vigilance Test (PVT), commonly utilized as an object risk assessment tool to quantify fatigue and sustained attention in laboratory, clinical, and operational settings. These strains were used to determine if genetic differences in dopaminergic function would impact radiation-induced deficits in sustained attention. Exposure to head-only proton irradiation (25 or 100 cGy) disrupted rPVT performance in a strain-specific manner, with 25 cGy-exposed Fischer 344 rats displaying the most severe deficits in sustained attention (i.e., decreased accuracy and increased premature responding); Lewis rats did not display behavioral deficits following radiation. Fischer 344 rats displayed greater tyrosine hydroxylase and dopamine transporter levels in the frontal cortex compared to the Lewis rats, even though radiation exposure increased both of these proteins in the Lewis rats only. Tyrosine hydroxylase was decreased in the parietal cortex of both rat strains following radiation exposure, regardless of proton dose. Strain-specific cytokine changes were also found in the frontal cortex, with the Lewis rats displaying increased levels of putative neurotrophic cytokines (e.g., CNTF). These data support the hypothesis that basal dopaminergic function impacts the severity of radiation-induced deficits in sustained attention.

Catherine M Davis↗

AIRS Point Spread Function Reconstruction using AIRS and MODIS Data

The purpose of this work is to use data from the Atmospheric Infrared Sounder (AIRS) and the Moderate Resolution Imaging Spectroradiometer (MODIS) to refine our knowledge of post-launch AIRS point spread functions (PSFs), including suspected changes over the mission. We develop methodology, by deriving mathematical optimization formulation based on variational principles and Sobolev gradient descent, for reconstruction of AIRS spatial response functions. We use the data over the ocean, collected for the duration of a day, to reconstruct a single PSF. We examine the repeatability of our reconstructions by computing PSFs based on data collected during two consecutive days, and also investigating the change in the reconstructions by comparing the reconstructed PSF based on data collected in the beginning and the middle of the mission. We also quantify uncertainties in our reconstruction results.

Vese, Luminita↗

System Level TVAC Functional Testing for the Integrated LCRD Low-Earth Orbit User Modem and Amplifier Terminal (ILLUMA-T) Payload Destined for the International Space Station

The Integrated LCRD Low-Earth Orbit User Modem and Amplifier Terminal (ILLUMA-T) Payload will be launched to the International Space Station (ISS) in 2023. ILLUMA-T is an optical communications payload that will make the ISS the first space-based user to communicate with NASA’s Laser Communications Relay Demonstration (LCRD). The system will support all-optical forward links up to 150 Mbps and return links up to 1 Gbps. The payload recently underwent system level Thermal VACuum (TVAC) functional testing at MIT Lincoln Laboratory. We present an overview of the payload’s TVAC functional tests and results.

lasercom↗

Galaxy Correlation Function and Local Density from Photometric Redshifts Using the Stochastic Order Redshift Technique (SORT)

The stochastic order redshift technique (SORT) is a simple, efficient, and robust method to improve cosmological redshift measurements. The method relies upon having a small (∼10 per cent) reference sample of high-quality redshifts. Within pencil- beam-like sub-volumes surrounding each galaxy, we use the precise dN/dz distribution of the reference sample to recover new redshifts and assign them one-to-one to galaxies such that the original rank order of redshifts is preserved. Preserving the rank order is motivated by the fact that random variables drawn from Gaussian probability density functions with different means but equal standard deviations satisfy stochastic ordering. This process is repeated for sub-volumes surrounding each galaxy in the survey. This results in every galaxy being assigned multiple ‘recovered’ redshifts from which a new redshift estimate is determined. An earlier paper applied SORT to a mock Sloan Digital Sky Survey at z 0.2 and accurately recovered the two-point correlation function (2PCF) on scales > 4 h−1Mpc. In this paper, we test the performance of SORT in surveys spanning the redshift range 0.75 < z < 2.25. We used two mock surveys extracted from the Small MultiDark–Planck and Bolshoi–Planck N-body simulations with dark matter haloes that were populated by the Santa Cruz semi-analytic model. We find that SORT overall improves redshift estimates, accurately recovers the redshift-space 2PCF ξ (s) on scales > 2.5 h−1Mpc, and provides improved local density estimates in regions of average or higher density, which may allow for improved understanding of how galaxy properties relate to their environments.

James Kakos↗

The Reliability Function

Mathematically, reliability is the probability of success. First, we will present the calculus needed to comprehend basic probability theory. Second, we will introduce The Reliability Function and its basic properties. Last, we will demonstrate The Reliability Function in a notional fatigue life example.

Reliability↗

Field Assessment of Sensorimotor Function Following Long-Duration Spaceflight

INTRODUCTION: Field assessments of functional task performance following long duration spaceflight are critical to characterize the risk associated with sensorimotor adaptation. A portable test battery involving sit-to-stand, prone-to-stand, walk and turn with obstacle, and tandem walking has been implemented during pre- and postflight testing to provide Sensorimotor Standard Measures that could be implemented in remote test locations. METHODS: To date, 19 astronauts (12 males, 7 females) participated in this study before and after 6–8-month expeditions to the International Space Station (198 ± 70 days, mean ±std). Ethics approvals were obtained, and all subjects provided informed consent. Tests were conducted preflight, within a few hours after landing, and then 1 day and 6–11 days later. Time to stability was the outcome measure for both standing tasks, time to completion and turn rate for the walk and turn task, and percent complete steps for the tandem walking (eyes open and closed). Statistical analyses included mixed effects (multi-level) generalized linear models. RESULTS: Consistent with previous Field Tests, significant effects of spaceflight were observed during the initial testing including longer times to stabilize posture when standing, longer times to complete the short obstacle walk, and fewer correct steps during tandem walking. The recovery timeline varied with task complexity, generally taking longer when either the basis of support was limited (e.g., tandem walk) and/or visual cues were deprived (eyes closed). DISCUSSION: These data suggest that additional sensorimotor-based countermeasures may be necessary to maintain functional performance during long-duration spaceflight. Maintaining core measures as new countermeasures are implemented during future missions will be instrumental in assessing their efficacy. This test battery will also serve as the basis for developing sensorimotor assessments during future space exploration.

Scott Jonathan Wood↗

Comparison of Corcos-Based and Experimentally-Derived Coherence Factors for Buffet Forcing Functions Estimation

In this paper, high-spatial-resolution unsteady Pressure Sensitive Paint (uPSP) data are utilized to compare two methods for panel Buffet Forcing Functions (BFF) estimation for the Space Launch System (SLS). Such methods are based on discrete pressure measurements within a panel but employ coherence factors to account for partially-correlated fluctuating pressures across the whole panel. In one method, coherence factors are derived based on the Corcos model, whereas the second method utilizes experimentally-derived coherence factors. To simulate discrete measurements using uPSP data, suitable subsets of the data are extracted. When full uPSP resolution is retained, uPSP data provide a benchmark to assess discrete-measurements-based methods. The analysis focuses on the peak SLS buffet environment located downstream of the Forward Attachment Hardware (FAH) between the core stage and solid rocket boosters. Trends of Corcos-based and experimentally-derived coherence factors are in reasonable agreement with the benchmark. However, at certain frequencies, experimentally-derived coherence factors are sensitive to the separation distance between pressure measurements utilized to compute coherence lengths. Such sensitivity originates from deviation of the experimental-based coherence function from an exponential decay assumption. On the other hand, the present implementation of the Corcos model fails to capture certain nonturbulent boundary layer related environments, such as a subharmonic of FAH vortex-shedding. For all methods presented in this paper, at near transonic conditions, increased pressure coherence and spatial nonuniformity lead to BFF overestimation and sensitivity to the pressure measurement location within the panel.

buffet↗

Comparison of Corcos-Based and Experimentally-Derived Coherence Factors for Buffet Forcing Function Estimation

In this paper, high-spatial-resolution unsteady Pressure Sensitive Paint (uPSP) data are utilized to compare two methods for panel Buffet Forcing Function (BFF) estimation for the Space Launch System (SLS). Such methods are based on discrete pressure measurements within a panel but employ coherence factors to account for partially-correlated fluctuating pressures across the whole panel. In one method, coherence factors are derived based on the Corcos model, whereas the second method utilizes experimentally-derived coherence factors. To simulate discrete measurements using uPSP data, suitable subsets of the data are extracted. When full uPSP resolution is retained, uPSP data provide a benchmark to assess discrete-measurement-based methods. The analysis focuses on the peak SLS buffet environment located downstream of the Forward Attachment Hardware (FAH) between the core stage and solid rocket boosters. Trends of Corcos-based and experimentally-derived coherence factors are in reasonable agreement with the benchmark. However, at certain frequencies, experimentally-derived coherence factors are sensitive to the separation distance between pressure measurements utilized to compute coherence lengths. Such sensitivity originates from deviation of the experimentally-based coherence function from an exponential decay assumption. On the other hand, the present implementation of the Corcos model fails to capture certain nonturbulent boundary layer related environments, such as a subharmonic of FAH vortex-shedding. For all methods presented in this paper, at near transonic conditions, increased pressure coherence and spatial nonuniformity lead to BFF overestimation and sensitivity to the pressure measurement location within the panel.

transonic buffet↗

System Level TVAC Functional Testing for the Integrated LCRD Low-Earth Orbit User Modem and Amplifier Terminal (ILLUMA-T) Payload Destined for the International Space Station

The Integrated LCRD Low-Earth Orbit User Modem and Amplifier Terminal (ILLUMA-T) payload will be launched to the International Space Station (ISS) in 2023. ILLUMA-T is an optical communications payload that will make the ISS the first space-based user to communicate with NASA’s Laser Communications Relay Demonstration (LCRD). The system will support all-optical forward links up to 150 Mbps and return links up to 1 Gbps. The payload recently underwent system level Thermal VACuum (TVAC) functional testing at MIT Lincoln Laboratory. We present an overview of the payload’s TVAC functional tests and results.

laser communications↗

Design of synthetic collagens that assemble into supramolecular banded fibers as a functional biomaterial testbed

Collagens are the most abundant proteins of the extracellular matrix, and the hierarchical folding and supramolecular assembly of collagens into banded fibers is essential for mediating cell-matrix interactions and tissue mechanics. Collagen extracted from animal tissues is a valuable commodity, but suffers from safety and purity issues, limiting its biomaterials applications. Synthetic collagen biomaterials could address these issues, but their construction requires molecular-level control of folding and supramolecular assembly into ordered banded fibers, comparable to those of natural collagens. Here, we show an innovative class of banded fiber-forming synthetic collagens that recapitulate the morphology and some biological properties of natural collagens. The synthetic collagens comprise a functional-driver module that is flanked by adhesive modules that effectively promote their supramolecular assembly. Multiscale simulations support a plausible molecular-level mechanism of supramolecular assembly, allowing precise design of banded fiber morphology. We also experimentally demonstrate that synthetic fibers stimulate osteoblast differentiation at levels comparable to natural collagen. This work thus deepens understanding of collagen biology and disease by providing a ready source of safe, functional biomaterials that bridge the current gap between the simplicity of peptide biophysical models and the complexity of in vivo animal systems.

Jinyuan Hu↗

Microbial Adaptation to Spaceflight Is Correlated With Bacteriophage-Encoded Functions

Evidence from the International Space Station suggests microbial populations are rapidly adapting to the spacecraft environment; however, the mechanism of this adaptation is not understood. Bacteriophages are prolific mediators of bacterial adaptation on Earth. Here we survey 245 genomes sequenced from bacterial strains isolated on the International Space Station for dormant (lysogenic) bacteriophages. Our analysis indicates phage-associated genes are significantly different between spaceflight strains and their terrestrial counterparts. Additionally, we identify 283 complete prophages, those that could initiate bacterial lysis and infect additional hosts, of which 21% are novel. These prophage regions encode functions that correlate with increased persistence in extreme environments, such as spaceflight, to include antimicrobial resistance and virulence, DNA damage repair, and dormancy. Our results correlate microbial adaptation in spaceflight to bacteriophage-encoded functions that may impact human health in spaceflight.

Space Biology↗

Capitol Reef Ecological Conservation: Mapping Vegetation Functional Groups to Inform Invasive Vegetation Management, Ecological Conservation and Restoration in Capitol Reef National Park

Invasive exotic plant (IEP) species have been found within the park boundaries of Capitol Reef National Park (CARE) in Utah. Currently, remotely sensed datasets such as the Rangeland Analysis Platform (RAP) from the United States Department of Agriculture (USDA) have been used to investigate IEP species within the park, but validation of the national RAP program is necessary for informing decisions at a local scale. CARE seeks a remote monitoring solution that can precisely target managerial efforts within the park’s challenging terrain and hard-to-reach locations. To fulfill this objective, we harnessed Landsat 8 Operational Land Imager (OLI) imagery and leveraged Random Forest (RF) modeling to generate classification maps characterizing vegetation functional groups for 2013 and 2022 within the park. Subsequently, the Land Change Modeler (LCM) in Idrisi TerrSet facilitated the production of a predicted classification map for 2033. The team also devised an annual grass probability map to accentuate areas impacted by exotic grasses. A comparative assessment between the RF classification map and the RAP map for 2022 revealed an overall agreement of 47.41%, with disparities primarily arising from differences in bare soil and shrub areas. Significantly, the 2022 RF-generated classification map showcased an impressive overall accuracy of 92.17%. In short, the probability map, the land cover change detection spanning 2013 to 2022, and the forecasting of observed trends into the future aids in the evaluation of invasive plant impacts and facilitation of CARE’s preparedness for potential ecological disturbances. Notably, in comparison to the RAP, the RF classification method generates functional group maps that are more representative of the study area.

Vanchy Li↗

2023 Astrophotonics Roadmap: Pathways to Realizing Multi-Functional Integrated Astrophotonic Instruments

Photonic technologies offer numerous functionalities that can be used to realize astrophotonic instruments. The most spectacular example to date is the ESO Gravity instrument at the Very Large Telescope in Chile that combines the light-gathering power of four 8 m telescopes through a complex photonic interferometer. Fully integrated astrophotonic devices stand to offer critical advantages for instrument development, including extreme miniaturization when operating at the diffraction-limit, as well as integration, superior thermal and mechanical stabilization owing to the small footprint, and high replicability offering significant cost savings. Numerous astrophotonic technologies have been developed to address shortcomings of conventional instruments to date, including for example the development of photonic lanterns to convert from multimode inputs to single mode outputs, complex aperiodic fiber Bragg gratings to filter OH emission from the atmosphere, complex beam combiners to enable long baseline interferometry with for example, ESO Gravity, and laser frequency combs for high precision spectral calibration of spectrometers. Despite these successes, the facility implementation of photonic solutions in astronomical instrumentation is currently limited because of (1) low throughputs from coupling to fibers, coupling fibers to chips, propagation and bend losses, device losses, etc, (2) difficulties with scaling to large channel count devices needed for large bandwidths and high resolutions, and (3) efficient integration of photonics with detectors, to name a few. In this roadmap, we identify 24 key areas that need further development. We outline the challenges and advances needed across those areas covering design tools, simulation capabilities, fabrication processes, the need for entirely new components, integration and hybridization and the characterization of devices. To realize these advances the astrophotonics community will have to work cooperatively with industrial partners who have more advanced manufacturing capabilities. With the advances described herein, multi-functional integrated instruments will be realized leading to novel observing capabilities for both ground and space based platforms, enabling new scientific studies and discoveries.

astrophotonics↗

A Multi-Faceted Approach to Demonstrating Multi-Functional Integrated Medical Devices to Advance Earth-Independent Medical Operations

INTRODUCTION TO MIM DEVICES Multi-functional Integrated Medical (MIM) devices conveniently incorporate multiple medical system capabilities within one device. The NASA Exploration Medical Integrated Product Team (XM-IPT) sponsored a market survey and trade study which identified the Tempus ProTM and the LifeBot 10® as the MIM devices that best met the evaluation criteria of the trade study. The Tempus ProTM (Remote Diagnostic Technologies, Ltd., Philips Corp., Farnborough, UK) and LifeBot 10® (LifeBot Health, Chicago, IL) both provide vital sign measurements such as blood pressure, electrocardiograms, heart rate, end tidal CO2, respiration rate, pulse oximetry and temperature along with ultrasound imaging. A video laryngoscopy capability is unique to the Tempus ProTM, while the LifeBot 10® supports connectivity with a digital stethoscope, otoscope, eye exam camera, and dermatoscope. Both devices include procedural guidance capabilities and have various data transmission and report generation features. TECHNOLOGY DEMONSTRATIONS NASA’s exploration-class missions will have severe resource constraints, long return trip durations, significant communication delays, and limited resupply opportunities. The medical systems of these missions will need to fit within an Earth-Independent Medical Operations (EIMO) construct. Key features of an EIMO medical system include: 1) technologies that support the prevention, diagnosis, and treatment of spaceflight medical events; 2) components that meet mass, volume, power and crew time/training constraints; 3) consideration of the medical skill level of the astronaut caregiver; 4) collection, storage and analysis of medical data within a central data architecture; and 5) incorporation of appropriate guidance and support tools that allow crew autonomy. Evaluations are underway to determine if it will be beneficial to include MIM devices within exploration medical systems by conducting a series of planned technical demonstrations. Exploration Atmosphere Chamber studies are being performed to determine MIM functionality in a high oxygen concentration atmosphere. A side-by-side comparison of the Tempus ProTM and LifeBot 10® will be performed during ground-based demonstrations. Use of the MIM devices within an EIMO medical scenario simulation will be practiced during ground-based demonstrations in preparation for International Space Station (ISS) demonstrations of the MIM device. These various demonstrations are designed to gather evidence for or against the inclusion of MIM devices within an EIMO medical system. EXPECTED DEMONSTRATION OUTCOMES Information will be gained about the feasibility, benefits, and challenges of using a multifunctional, all-in-one, medical device for medical diagnosis. Information will also be collected about performance differences as available ground support decreases. Gaining this understanding will allow for further development of exploration medical system capabilities, which take the EIMO construct into consideration.

B. E. Lewandowski↗

A Uniform Analysis of Debris Discs with the Gemini Planet Imager II: Constraints on Dust Density Distribution Using Empirically Informed Scattering Phase Functions

Spatially resolved images of debris discs are necessary to determine disc morphological properties and the scattering phase function (SPF) thatantifies the brightness of scattered light as a function of phase angle. Current high-contrast imaging instruments have successfully resolved several dozens of debris discs around other stars, but few studies have investigated trends in the scattered-light, resolved population of debris discs in a uniform and consistent manner. We have combined Karhunen-Loeve Image Projection (KLIP) with radiative-transfer disc forward modelling in order to obtain the highest-quality image reductions and constrain disc morphological properties of eight debris discs imaged by the Gemini Planet Imager at H -band with a consistent and uniformly applied approach. In describing the scattering properties of our models, we assume a common SPF informed from solar system dust scattering measurements and apply it to all systems. We identify a diverse range of dust density properties among the sample, including critical radius, radial width, and vertical width. We also identify radially narrow and vertically extended discs that may have resulted from substellar companion perturbations, along with a tentative positive trend in disc eccentricity with relative disc width. We also find that using a common SPF can achieve reasonable model fits for discs that are axisymmetric and asymmetric when fitting models to each side of the disc independently, suggesting that scattering behaviour from debris discs may be similar to Solar system dust.

scattering↗

Functional Task Tests in Partial Gravity During Parabolic Flight

BACKGROUND Understanding how critical mission tasks are performed in partial gravity such as on the moon or Mars is necessary to define effective and comprehensive countermeasure strategies for preserving crew performance during exploration missions. We studied the performance of tasks such as standing, balancing, walking, and jumping during the partial gravity phases of parabolic flight. We hypothesized that the acute effects of partial gravity on vestibular, proprioceptive, and sensorimotor functions would negatively impact performance. METHODS Twelve subjects (6F, 6M; 40.2 ± 8.5 years) were tested over three flights of 30 parabolas each, including 10 parabolas at 0.25g, 10 parabolas at 0.5g, and 10 parabolas at 0.75g. Subjects also performed tests in 1g between parabolas. During the seat egress and walk task, subjects rose from a seated position and walked as quickly as possible straight ahead towards a cone (4 m distance), stepped over a 30 cm high obstacle, walked around the cone making a 180° left turn, returned to the chair, and sat down in the chair. Other tasks included a tandem stance on rails, jump down from a 30cm platform, recovery from fall (prone to stand), and limits of stability tasks. Data were collected using inertial measurement units (Opal V2, APDM, Portland, OR) worn on the head and trunk, heart rate monitors (Polar, Finland), and a force plate (Bertec, Columbus, OH). During the jump down and limits of stability tasks, falls were recorded if subjects took extra steps, lifted their heels/toes, or used their arms to recover balance. RESULTS Gravity level had a significant effect on performance, with the greatest changes from 1g tending to be at the 0.25g level (Table 1). Lower gravity levels were associated with increased times to complete the seat egress and walk task and the recovery from fall task, increased head-trunk coordination, decreased tandem stance rail balance times, decreased change in heart rate during the recovery from fall task, and increased cone of stability distance in the anterior-posterior direction. In addition, there were significantly more falls recorded at the lower gravity levels: 31 falls at 0.25g, 14 falls at 0.5g, 6 falls at 0.75g, and 6 falls at 1g. DISCUSSION These data suggest that there is a dose-response relationship between gravity level and functional task performance. The largest changes in performance were expected at the lowest gravity level (0.25g) because subjects would no longer be able to use the gravitational reference for the perception of upright. Understanding the extent of performance deficits informs the risks and design of countermeasures for exploration spaceflight missions.

T R Macaulay↗

Shape Servoing of Deformable Objects Using Model Estimation and Barrier Lyapunov Function

An adaptive shape servoing control method is presented in this article to manipulate a deformable object into a desired shape in 3-D. A finite-point-based representation of the deformable object is used and the deformation Jacobian matrix is approximated using Fourier series basis functions. The unknown parameters of the deformation Jacobian are learned by using the velocity applied to a control point on the object and corresponding change of positions of the points describing the entire object. An integral concurrent learning (ICL)-based parameter update law is designed along with a constrained controller to satisfy the state constraints on the motion of the control point using Barrier Lyapunov function analysis. ICL-based parameter update law uses data history of velocity and corresponding positions of the points along with their current values. An efficient algorithm to update the history stack using singular value maximization is proposed based on the structure of the regressor matrix. Simulations using a physical simulator and experiments using a robot platform are performed to validate the performance of the proposed controller on two different deformable objects.

Vrithik Raj Guthikonda↗

Electromagnetic Melt Processing: A Pathway to New Additive Manufacturing Technologies for Functional High-Performance Thermoplastics

In this study, we apply the electromagnetic (EM) melt processing of thermoplastics on an innovative EM field-driven powder bed fusion additive manufacturing (AM) concept for high-performance functional parts: Selective Microwave Melting/Sintering (SMM/SMS). This technique leverages the EM susceptibility of carbon nanotube-coated polymer micro-pellets to achieve rapid, localized heating and powder fusion. Thus, selective microwave melting (SMM) was used to fabricate multilayer specimens made of recycled polyphenylene sulfide (rPPS) and carbon nanotubes (CNTs). The resulting SMM specimens exhibited very good interlayer integrity, localized fusion at pellet boundaries, and tolerable residual porosity, indicating effective fusion and acceptable consolidation. CNT-rich interphases were retained after irradiation, generating anisotropic electrically active network pathways and enabling conductivity enhancement at low filler content. At only 1.0 wt% CNT, the specimens exhibited electrical conductivity approximately three orders of magnitude higher than neat rPPS. Dynamic mechanical analysis showed improved viscoelastic response relative to neat rPPS, while tensile testing confirmed that the SMM-processed specimens retained practical mechanical integrity despite localized voids. These results demonstrate that SMM can effectively consolidate EM susceptible thermoplastic powder beds while preserving their segregated conductive networks. This may become a scalable route for producing multifunctional thermoplastic parts with low filler loadings, tunable anisotropy, and structured materials and parts. Overall, the findings suggest that EM field-based AM can help overcome key limitations of conventional thermoplastic processing by enabling scalable, energy-efficient fabrication of nanostructured composites and expanding AM to a broader range of resins, including high-performance thermoplastics with customized functional properties.

Powder bed fusion↗