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Surface pressures, impact and static pressure distributions in the flow field over the plate, and local heating rates were measured on a flat plate with various leading-edge diameters. The tests were conducted at a Mach number of 4.7 and a free-stream Reynolds number of 3.8 x 10(exp 6) per foot.
Results of an investigation of the aerodynamic loads on a canard airplane model are presented without detailed analysis for the Mach number range of 0.70 t o 2.22. The model consisted of a triangular wing and canard of aspect ratio 2 mounted on a Sears-Haack body of fineness ratio 12.5 and either a single body-mounted vertical tail or twin wing mounted vertical tails of low aspect ratio and sweptback plan form. The body, right wing panel, single vertical tail, and left twin vertical tail were instrumented for measuring pressures. Data were obtained for angles of attack ranging from -4 degrees to +16 degrees, nominal canard deflection angles of 0 degrees and 10 degrees, and angles of sideslip of 0 degrees and 5.3 degrees. The Reynolds number was 2.9 x 10(exp 6) based on the wing mean aerodynamic chord. Selected portions of the data are presented in graphical form and attention is directed to some of the results of the investigation. All of the experimental results have been tabulated in the form of pressure coefficients and integrations of the pressure coefficients and are available as supplements to this paper. A brief summary of the contents of the tabular material is given.
Tabulated results of a wind-tunnel investigation of the aerodynamic loads on a canard airplane model with a single vertical tail are presented for Mach numbers from 0.70 to 2.22. The Reynolds number for the measurements was 2.9 x 10(exp 6) based on the wing mean aerodynamic chord. The results include local static pressure coefficients measured on the wing, body, and vertical tail for angles of attack from -4 deg to + 16 deg, angles of sideslip of 0 deg and 5.3 deg, vertical-tail settings of 0 deg and 5 deg, and nominal canard deflections of 0 deg and 10 deg. Also included are section force and moment coefficients obtained from integrations of the local pressures and model-component force and moment coefficients obtained from integrations of the section coefficients. Geometric details of the model and the locations of the pressure orifices are shown. An index to the data contained herein is presented and definitions of nomenclature are given.
A wind-tunnel investigation has been conducted to determine the aerodynamic characteristics of two preliminary designs of the Scout research vehicle. The first model was tested at Mach numbers from 1.77 to 2.87 at Reynolds numbers of 3.7 x 10(exp 6) to 4.0 x 10(exp 6) per foot. A variable angle-of-attack range of -2 degrees to 14 degrees was used in determining the effect of nose shape, size of interstage flare base diameter, size of trapezoidal first-stage fins, and fin tip-control deflection on the aerodynamic characteristics of the model.
An experimental investigation was conducted to evaluate the heat-transfer characteristics of two 60 deg swept delta wings with cylindrical leading edges of 0.25-inch radii and dihedral angles of 0 deg and 45 deg. The tests were conducted at a Mach number of 4.95 and a stagnation temperature of 400 F. The The test-section unit Reynolds number was varied from 1.95 x 10(exp 6) to 12.24 x 10(exp 6) per foot. The results of the investigation indicated that, in a plane normal to the leading edge, the laminar-flow heat-transfer distribution was in good agreement with two-dimensional blunt-body theory. The stagnation-line heat-transfer level could be predicted from two-dimensional blunt-body theory provided the stagnation-line heat-transfer coefficient was assumed to vary as the cosine of the effective sweep. A comparison of the heating rates to the 0 deg dihedral wing (planform sweep of 60 deg) and the 45 deg dihedral wing (planform sweep of 69.3 deg) with equal panel sweep and panel area indicated that the stagnation-line heat-transfer coefficient for the 45 deg dihedral wing could be as much as 40 percent less than the stagnation-line heat-transfer coefficient for the 0 deg dihedral wing at both equal angles of attack and equal lifts. The laminar-flow heat-transfer rate to both wings outside the vicinity of the stagnation line was essentially equal.
An experimental investigation was conducted to evaluate the heat-transfer rates at the apex of two 60 degree sweptback delta wings (panel semi-apex angle of 30 degrees) having cylindrical leading edges and 0 degrees and 45 degree positive dihedral. The models tested might correspond to the first several feet of a hypersonic reentry vehicle. The tests were conducted at a Mach number of 4.95 and a stagnation temperature of 400 F. nominal test-section unit Reynolds numbers varied from 2 x 10(exp 6) to 12 x 10(exp 6) per foot. The results of the investigation indicated that the laminar heat-transfer distributions (ratio of local to stagnation-line heating rate) about the models normal to the leading edges were in close agreement with two-dimensional blunt-body theory. The three-dimensional stagnation point heat-transfer rate on the 0 degree dihedral model was in excellent agreement with theory and the stagnation-line heat transfer on the straight portion of the leading edge of both models approached a constant level 12 percent above the theoretical stagnation-line level on an isolated swept infinite cylinder. When the heating rates on the 45 degree dihedral model (planform sweep of 69.3 degree) were compared with those on the 0 degree dihedral model (planform sweep of 60 degrees) at equal angles of attack and equal lifts greater than zero, the stagnation-line heating rates on the 45 degrees dihedral model were, in general, considerably lower as a result of the difference in effective sweeps of the leading edges. On the wing panels inboard from the stagnation lines, the differences in heating were very small. The stagnation-line heat-transfer variation with angle of attack, the shift in stagnation-line location, and the reduction in stagnation-line heat transfer resulting from the increase in effective sweep when positive dihedral is incorporated into a constant-panel 0 degree dihedral wing, all agreed with the results of a theoretical study made of highly swept delta wings with large positive dihedral.
Pressure distributions are presented on four wings: an untwisted wing to serve as a reference, and wings with linear, quadratic and cubic twist variations along the span. All the twisted wings had 0deg twist at the 10-percent-semispan station and 6deg twist at the tip. The tests were made at a Mach number of 1.43 and covered an angle-of-attack range from -4deg to 20deg. The average Reynolds number based on the wing mean aerodynamic chord was 2.9 x 10(exp 6) during tests at a stagnation pressure of 1.0 atmosphere and 1.5 x 10(exp 6) during tests at a stagnation pressure of 0.5 atmosphere.
A flight investigation was conducted to determine the effects of inlet modification and rocket-rack extension on the longitudinal trim and low-lift drag of the Douglas F5D-1 airplane. The investigation was conducted with a 0.125-scale rocket-boosted model between Mach Numbers of 0.81 and 1.64. This paper presents the changes in trim angle of attack, trim lift coefficient, and low-lift drag caused by the modified inlets alone over a small part of the test Mach number range and by a combination of the modified inlets and extended rocket racks throughout the remainder of the test.
Quantitative analysis of vascular generational branching demonstrated that transforming growth factor-beta1 (TGF-beta1), a multifunctional cytokine and angiogenic regulator, strongly inhibited angiogenesis in the arterial tree of the developing quail chorioallantoic membrane (CAM) by inhibition of the normal increase in the number of new, small vessels. The cytokine was applied uniformly in solution at embryonic day 7 (E7) to the CAMs of quail embryos cultured in petri dishes. After 24 h the rate of arterial growth was inhibited by as much as 105% as a function of increasing TGF-beta1 concentration. Inhibition of the rate of angiogenesis in the arterial tree by TGF-beta1 relative to controls was measured in digital images by three well-correlated, computerized methods. The first computerized method, direct measurement by the computer code VESGEN of vascular morphological parameters according to branching generations G(sub 1) through G(sub greater than or equal to 5), revealed that TGF-beta1 selectively inhibited the increase in the number density of small vessels, N(sub v greater than or equal to 5), (382 plus or minus 85 per square centimeter) for specimens treated with 1 microgram TGF-beta1/CAM for 24 h, compared to 583 plus or minus 99 per square centimeter for controls), but did not significantly affect other parameters such as average vessel length or vessel diameter. The second and third methods, the fractal dimension (D(sub f)) and grid intersection (rho (sub v)), are statistical descriptors of spatial pattern and density. According to D(sub f) and rho(sub v), arterial density increased in control specimens from 1.382 plus or minus 0.007 and 662 plus or minus 52 per square centimeters at E7 (0 h) to 1.439 plus or minus 0.013 and 884 plus or minus 55 per square centimeters at E8 (24 h), compared to 1.379 plus or minus 0.039 and 650 plus or minus 111 per square centimeter for specimens treated with 1 microgram TGF-beta1/CAM for 24 h. TGF-beta1 therefore regulates vascular pattern and the rate of angiogenesis in a unique fingerprint manner, as do other major angiogenic regulators that include VEGF, FGF-2 (bFGF), and angiostatin. TGF-beta1 did not stimulate angiogenesis significantly at low cytokine concentrations, which suggests that this quail CAM model of angiogenesis is not associated with an inflammatory response.
An experimental investigation has been conducted at Mach numbers of 0.6 to 1.4 to determine the base pressures on several cylindrical afterbody configurations having two propulsive nozzles and to determine the effect on base pressure of stabilizing fins and the canting outward of the propulsive nozzles. Nozzle design Mach numbers of 2.0 and 3.43 were employed in this investigation and cold air at total pressures up to 120 times the free-stream static pressure was used to simulate nozzle flow. The results show that canting the nozzles outward 11 degrees was effective in increasing base pressures at supersonic speeds and that stabilizing fins caused a decrease in base pressure. The magnitudes of base pressure coefficients obtained in this investigation were consistent with those obtained on similar configurations in previous jet-effect investigations.
An investigation has been made to determine the effect of Reynolds number on the lateral-stability derivatives at low speed of sweptback- and delta-wing-fuselage combinations. Results were obtained from the models oscillating in yaw over an angle-of-attack range from 0 degrees to 32 degrees for the delta-wing models and from 0 degrees to 28 degrees for the sweptback-wing model. The Reynolds number range was from 0.7 x 10(exp 6) for the sweptback-wing model and from 0.9 x 10(exp 6) to 9 x 10(exp 6) for the delta-wing models. The tests were run for amplitudes of oscillation from 2 degrees to 10 degrees and reduced-frequency parameters from 0.028 to 0.113. The results of this investigation are presented without discussion, but data figures are indexed in tabular form to facilitate their use.
A free-flight investigation of an airplane configuration having a low 52.5 deg. delta wing and an unswept horizontal tail has been conducted over a Mach number range of 1.40 to 2.78. At a fixed tail setting of -3.0 deg., the trim lift coefficient and angle of attack varied from about 0.12 to 0.04 and 3.8 deg. to 2.0 deg., respectively. The base drag was approximately 5 percent of the total drag at trim lift. Lift-curve slope, static longitudinal stability, and damping in pitch were obtained only at Mach numbers of 2.59 t o 2.74. Theoretical calculations of lift-curve slope and aerodynamic-center location were in good agreement with experimental results.
Experimental panel flutter data have been obtained at Mach numbers from 1.2 to 3.0 for buckled rectangular panels and the effect of a pressure differential has been determined. Increasing the pressure differential was effective in eliminating flutter on most of the panels tested. The effects of the variables in the panel flutter parameter ((square root of m(exp 2) -1) * (E/q))(exp 1/3) t/l (where M is the Mach number, q is the dynamic pressure, E is Young's modulus, and t and l are the panel thickness and length, respectively) were investigated for buckled panels clamped on the front and rear edges and a critical value of this parameter of 0.44 is indicated at zero pressure differential when the panel width-length ratio is 0.69. An estimated flutter boundary is presented for buckled panels clamped on four edges, with width-length ratios of 0.21 to 4.0. This boundary shows that the panel width is more significant than the panel length when the ratio of width to length is less than approximately 0.5. Panels clamped on four edges and buckled in two half waves in the direction of flow were found to be particularly susceptible to flutter. The results of limited tests on panels with applied damping, curvature, and lengthwise stiffeners are also presented and discussed.
Force tests of a series of right circular cones having semivertex angles ranging from 5 deg to 45 deg and a series of right circular cone-cylinder configurations having semivertex angles ranging from 5 deg to 20 deg and an afterbody fineness ratio of 6 have been made in the Langley 11-inch hypersonic tunnel at a Mach number of 6.83, a Reynolds number of 0.24 x 10.6 per inch, and angles of attack up to 130 deg. An analysis of the results made use of the Newtonian and modified Newtonian theories and the exact theory. A comparison of the experimental data of both cone and cone-cylinder configurations with theoretical calculations shows that the Newtonian concept gives excellent predictions of trends of the force characteristics and the locations with respect to angle of attack of the points of maximum lift, maximum drag, and maximum lift-drag ratio. Both the Newtonian a.nd exact theories give excellent predictions of the sign and value of the initial lift-curve slope. The maximum lift coefficient for conical bodies is nearly constant at a value of 0.5 based on planform area for semivertex angles up to 30 deg. The maximum lift-drag ratio for conical bodies can be expected to be not greater than about 3.5, and this value might be expected only for slender cones having semivertex angles of less than 5 deg. The increments of angle of attack and lift coefficient between the maximum lift-drag ratio and the maximum lift coefficient for conical bodies decrease rapidly with increasing semivertex angles as predicted by the modified Newtonian theory.
This has quantified a database of Markstein numbers for unsteady flames; future work will quantify a database of flame extinction limits for unsteady conditions. Unsteady extinction limits have not been documented previously; both a stretch rate and a residence time must be measured, since extinction requires that the stretch rate be sufficiently large for a sufficiently long residence time. Ma was measured for an inwardly-propagating flame (IPF) that is negatively-stretched under microgravity conditions. Computations also were performed using RUN-1DL to explain the measurements. The Markstein number of an inwardly-propagating flame, for both the microgravity experiment and the computations, is significantly larger than that of an outwardy-propagating flame. The computed profiles of the various species within the flame suggest reasons. Computed hydrogen concentrations build up ahead of the IPF but not the OPF. Understanding was gained by running the computations for both simplified and full-chemistry conditions. Numerical Simulations. To explain the experimental findings, numerical simulations of both inwardly and outwardly propagating spherical flames (with complex chemistry) were generated using the RUN-1DL code, which includes 16 species and 46 reactions.
The sedimentation dynamics of extremely low polydispersity, non-colloidal, particles are studied in a liquid fluidized bed at low Reynolds number, Re much less than 1. When fluidized, the system reaches a steady state, defined where the local average volume fraction does not vary in time. In steady state, the velocity fluctuations and the particle concentrations are found to strongly depend on height. Using our results, we test a recently developed stability model for steady state sedimentation. The model describes the data well, and shows that in steady state there is a balancing of particle fluxes due to the fluctuations and the concentration gradient. Some results are also presented for the dependence of the concentration gradient in fluidized beds on particle size; the gradients become smaller as the particles become larger and fewer in number.
Force tests were conducted at a Mach number of 6.0 on nose-cylinder-flare bodies to determine the effect of nose shape, cylinder length, flare angle, and flare length on the longitudinal aerodynamic characteristics. A particular investigation was conducted to determine the effect of flare angle for constant flare length, surface area, and diameter. Results indicated that at a Reynolds number of approximately 0.92 x l0 (exp 6) (based on body diameter), the boundary-layer separation effects were significant only with respect to the slope of the normal-force and pitching-moment curve at low angles of attack. The variations of the aerodynamic characteristics with the various parameters were, in general, similar to those predicted by Newtonian theory below a flare angle of 30 degrees and a ratio of flare base diameter to cylinder diameter of less than approximately 2.2. The limiting diameter ratio is consistent with the extent of the low-constant dynamic-pressure region near the body caused by the bow-shock influences as predicted by axisymmetric characteristic theory. The effects of the various parameters for the flares that exceeded the limiting diameter ratio follow the trends predicted by the computed flow-field properties. The axial force for these flare configurations at zero angle of attack was, in general, computed within 10 percent by using these properties. For a constant flare length and surface area the flare effectiveness increased with increasing flare angle; however, for constant flare diameter only the axial-force coefficient was affected by flare angle.
BACKGROUND: The identification of the function of all genes that contribute to specific biological processes and complex traits is one of the major challenges in the postgenomic era. One approach is to employ forward genetic screens in genetically tractable model organisms. In Drosophila melanogaster, P element-mediated insertional mutagenesis is a versatile tool for the dissection of molecular pathways, and there is an ongoing effort to tag every gene with a P element insertion. However, the vast majority of P element insertion lines are viable and fertile as homozygotes and do not exhibit obvious phenotypic defects, perhaps because of the tendency for P elements to insert 5' of transcription units. Quantitative genetic analysis of subtle effects of P element mutations that have been induced in an isogenic background may be a highly efficient method for functional genome annotation. RESULTS: Here, we have tested the efficacy of this strategy by assessing the extent to which screening for quantitative effects of P elements on sensory bristle number can identify genes affecting neural development. We find that such quantitative screens uncover an unusually large number of genes that are known to function in neural development, as well as genes with yet uncharacterized effects on neural development, and novel loci. CONCLUSIONS: Our findings establish the use of quantitative trait analysis for functional genome annotation through forward genetics. Similar analyses of quantitative effects of P element insertions will facilitate our understanding of the genes affecting many other complex traits in Drosophila.