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At least 163 records · Page 9

Model-independent measurement of the matter-radiation equality scale in DESI 2024

The peak of the matter power spectrum, known as the turnover (TO) scale, is determined by the horizon size at the time of matter-radiation equality. This scale can serve as a standard ruler, independent of other features in the matter power spectrum, such as baryon acoustic oscillations (BAO). Here, in this work, we present the first detection of the turnover in the galaxy autopower spectrum, utilizing the distribution of quasars and luminous red galaxies (LRG) measured by the Dark Energy Spectroscopic Instrument (DESI) during its first year of survey operations in a model-independent manner. To avoid confirmation bias, we first analyze the data using data blinding methods designed for the DESI baryon acoustic oscillation, redshift space distortion and scale-dependent bias signals. We measure the angle-averaged dilation distance 𝐷 V ⁡(𝑧 = 1.651) = (38.1 ± 2.5)⁢𝑟 H from the quasars and 𝐷 V ⁡(𝑧 = 0.733) = (21.8 ± 1.0)⁢𝑟 H from the LRG sample in units of the horizon 𝑟 H at the matter-radiation-equality epoch. Combining these two constraints and assuming a flat Λ⁢CDM model with three standard neutrino species, we can translate this into a constraint of Ω m ⁢ℎ 2 = 0.13⁢9$^{+0.036}_{−0.046}$. We can break the Ω m −𝐻 0 degeneracy with low-redshift distance measurements from type-Ia supernova (SN) data from Pantheon+, we obtain a sound-horizon free estimate of the Hubble-Lemaître parameter of 𝐻 0 = 65.2$^{+4.9}_{−6.2}$ km/s/Mpc, consistent with sound-horizon dependent DESI measurements. On the other hand, combining the DESI BAO and TO, we find a truly DESI-only measurement of 𝐻 0 = 74.0$^{+7.2}_{−3.5}$ km/s/Mpc, in line with DESI-only full-shape results where the sound-horizon scale is marginalized out. This discrepancy in 𝐻 0 can be reconciled in a 𝑤 0 ⁢𝑤 𝑎 ⁢ CDM cosmology, where the combination of DESI BAO and TO data yields 𝐻 0 = 66.5 ± 7.2 km/s/Mpc.

cosmological parameters↗

Thermo-rheological snapshot of melter feed conversion to glass

Slurry feed charged into an electric melter creates a layer of reacting and melting material (termed cold cap) that floats on the surface of molten glass. The rheological behavior of heated melter feed affects the spreading of slurry at the top of the cold cap and the stability of the primary foam, affecting cold-cap coverage and melter plenum temperatures. The apparent viscosity of a high-alumina high-level waste melter feed was assessed by thermomechanical analysis, high-temperature viscometer, and the hot stage microscopy method, yielding viscosity estimates from ≈10 7.5 Pa s at 550°C to ≈10 2.5 Pa s at 1050°C. As the temperature of feed materials increased, their state changed from rigid solid to dilatant fluid, to pseudoplastic bubbly liquid with dissolving solids, to fully developed foam, and finally to Newtonian glass melt.

12 MANAGEMENT OF RADIOACTIVE AND NON-RADIOACTIVE W↗

An FDA-approved drug structurally and phenotypically corrects the K210del mutation in genetic cardiomyopathy models

Dilated cardiomyopathy (DCM) due to genetic disorders results in decreased myocardial contractility, leading to high morbidity and mortality rates. There are several therapeutic challenges in treating DCM, including poor understanding of the underlying mechanism of impaired myocardial contractility and the difficulty of developing targeted therapies to reverse mutation-specific pathologies. In this report, we focused on K210del, a DCM-causing mutation, due to 3-nucleotide deletion of sarcomeric troponin T (TnnT), resulting in loss of Lysine210. We resolved the crystal structure of the troponin complex carrying the K210del mutation. K210del induced an allosteric shift in the troponin complex resulting in distortion of activation Ca 2+ -binding domain of troponin C (TnnC) at S69, resulting in calcium discoordination. Next, we adopted a structure-based drug repurposing approach to identify bisphosphonate risedronate as a potential structural corrector for the mutant troponin complex. Cocrystallization of risedronate with the mutant troponin complex restored the normal configuration of S69 and calcium coordination. Risedronate normalized force generation in K210del patient-induced pluripotent stem cell–derived (iPSC-derived) cardiomyocytes and improved calcium sensitivity in skinned papillary muscles isolated from K210del mice. Systemic administration of risedronate to K210del mice normalized left ventricular ejection fraction. Collectively, these results identify the structural basis for decreased calcium sensitivity in K210del and highlight structural and phenotypic correction as a potential therapeutic strategy in genetic cardiomyopathies.

Research & Experimental Medicine↗

Regulation of sarcomere formation and function in the healthy heart requires a titin intronic enhancer

Heterozygous truncating variants in the sarcomere protein titin (TTN) are the most common genetic cause of heart failure. To understand mechanisms that regulate abundant cardiomyocyte (CM) TTN expression, we characterized highly conserved intron 1 sequences that exhibited dynamic changes in chromatin accessibility during differentiation of human CMs from induced pluripotent stem cells (hiPSC-CMs). Homozygous deletion of these sequences in mice caused embryonic lethality, whereas heterozygous mice showed an allele-specific reduction in Ttn expression. A 296 bp fragment of this element, denoted E1, was sufficient to drive expression of a reporter gene in hiPSC-CMs. Deletion of E1 downregulated TTN expression, impaired sarcomerogenesis, and decreased contractility in hiPSC-CMs. Site-directed mutagenesis of predicted binding sites of NK2 homeobox 5 (NKX2-5) and myocyte enhancer factor 2 (MEF2) within E1 abolished its transcriptional activity. In embryonic mice expressing E1 reporter gene constructs, we validated in vivo cardiac-specific activity of E1 and the requirement for NKX2-5- and MEF2-binding sequences. Moreover, isogenic hiPSC-CMs containing a rare E1 variant in the predicted MEF2-binding motif that was identified in a patient with unexplained dilated cardiomyopathy (DCM) showed reduced TTN expression. Together, these discoveries define an essential, functional enhancer that regulates TTN expression. Manipulation of this element may advance therapeutic strategies to treat DCM caused by TTN haploinsufficiency.

Kim, Yuri↗

Mathematical Morphological Filtering with a Self-Adaptive Reconstruction Technique and Application to Local Seismic Data

Recorded seismic data are generally contaminated by noise from different sources, which masks the signals of interest. In the seismology community, frequency filtering (FF) is the standard method for noise suppression. However, when the signal of interest and noise share the same frequency band, the latter cannot be filtered out without infringing on the former. We implemented a noise suppression approach based on the mathematical morphology theorem. The method involves compound operations of dilation and erosion using structuring elements of varying lengths and decomposes an input noisy waveform into several time functions with differing characteristics. Further, the filtered waveform is constructed from the time functions using a self-adaptive reconstruction technique. Application to a data set of >4700 local waveforms suggests that the implemented mathematical morphological filtering (MMF) approach is efficient for data with low signal-to-noise ratio (SNR) and significantly outperforms FF in that SNR range. For most of the dataset, FF, machine learning (ML) denoising, and continuous wavelet transform (CWT) thresholding result in higher SNR values compared with the MMF method. However, for ~42% of the waveforms, MMF outperforms FF, and the SNR gain achieved with MMF is as large as ~23 dB. Compared to ML denoising and CWT thresholding, this proportion drops to only ~10%–14%. Our results suggests that in an operational setting, MMF cannot replace the other noise suppression methods; however, signal detection can be improved if MMF is used to supplement them in some scenarios. MMF could help detect signals in problematic low-SNR data, which are currently being missed particularly when using FF alone.

58 GEOSCIENCES↗

Determining Stress Orientation in Rock Valley, Nevada, Using Ambient Seismic Noise

The stress field and the mechanical properties of rocks are important to consider for nuclear explosion monitoring due to their effect on seismic wave radiation from earthquakes and explosions. At the Rock Valley Direct Comparison site, the regional orientation of the maximum horizontal compressive stress (SH max ) is well constrained, but it is unknown whether there are local heterogeneities. Here, I show that stress-induced anisotropy in nonlinear elasticity can be used to estimate the orientation of SH max . Rocks have compliant internal contacts, such as fractures and mineral grain boundaries, that respond to applied strains more strongly than individual mineral crystals. This strain response is asymmetric between compressive and dilatational strains and is affected by anisotropy in the ambient stress field. Traditional seismic velocity measurements are of strain-averaged velocity, which is less sensitive than nonlinear elasticity to the behavior of compliant internal contacts and therefore the stress field and fracture behavior. My results show that the orientation of SH max measured using ambient seismic noise aligns with regional estimates, with some heterogeneity that can also be explained by the limitations of the seismic array. I demonstrate the potential of a passive technique for monitoring the stress field in places that currently lack local measurements.

58 GEOSCIENCES↗

High Yield Xray Imager Final Design Review

The High Yield Xray Imager (HYXI) is a new NIF target diagnostic system currently under development. The goal of HYXI is to provide high-fidelity, high temporal resolution x-ray imaging capability on high yield NIF implosions at 10MJ and above. The HYXI instrument design concept is based on the combination of two technologies that have been successfully utilized at the NIF on previous instruments, electron pulse-dilation and hybrid-CMOS sensor imaging. The combination of these two techniques will give HYXI sufficient data quality to ascertain differences in hot spot formation dynamics between high and low yield implosions. This information will highlight the critical hot spot conditions needed for ignition and burn. The HYXI design leverages the successful operation of the PDIXI x-ray imager at the NIF on multi MJ yield shots. A new radiation tolerant CMOS imaging array (HYPERION) is being developed to eliminate the significant background noise which limits the data quality of PDIXI. We successfully placed the contract with Advanced hCMOS Systems (AHS) to develop the HYPERION sensor, which fulfils our criteria to place long lead time item procurements by end of FY24. The HYXI Final Design Review was completed at the end of Q4 FY24 (Sep 24 th and Sep 30 th ). The HYXI project is a multi-year effort with a phased approach to be bring up system functionality over time in parallel with the development and fabrication effort of the HYPERION CMOS imaging array. In Phase 1, time-integrated x-ray images on NIF DT experiments will be collected starting in Q3 FY25. In Phase 2 of the project, time-resolved imaging with HYXI utilizing a spare microchannel plate detector back-end will begin in Q3 FY26. Phase 3 concludes the project with the installation of the HYPERION sensor array and the final performance qualification of the HYXI instrument which is scheduled for Q3 FY27 as discussed in the PDR and MRT report on this project in FY23.

42 ENGINEERING↗

Multi-physics Topology OPtimization and Additive Manufacturing for High-temperature Heat Exchangers

This research significantly advances the understanding of high-temperature heat exchanger design through an integrated approach that combines topology optimization (TO), triply periodic minimal surface (TPMS) structures, additive manufacturing (AM) and thermohydraulic testing. Each of these components contributes uniquely to a unified, high-performance design, fabrication and testing workflow. Topology optimization serves as the foundation of the design methodology by providing a systematic way to determine the most effective material layout for separating hot and cold fluids while maximizing thermal performance. The researchers introduced a novel three-material optimization framework using two density fields to represent hot fluid, cold fluid, and solid domains. This approach enables automated discovery of optimal shapes and flow paths that cannot be intuitively designed, especially under constraints imposed by manufacturing technologies. Furthermore, constraints such as minimal wall thickness and overhang angles were embedded into the optimization process, ensuring that resulting designs are not only thermally efficient but also manufacturable using modern additive techniques. In parallel, the study delves into the use of Gyroid-based TPMS geometries for constructing the core of the heat exchanger. TPMS structures are known for their high surface area, excellent fluid mixing capabilities, and minimal pressure drop characteristics. The researchers applied a data-driven modeling framework using Heteroscedastic Sparse Gaussian Process Regression (HSGPR) combined with genetic algorithms. This allowed for the rapid evaluation and optimization of key geometric parameters such as frequency, iso-value, and phase shift. The result was a set of Gyroid structures tailored for high heat transfer and low flow resistance, demonstrating clear improvements over conventional straight-channel designs. After the designing process, additive manufacturing played a critical role by turning these highly complex, optimized geometries into physical components. Utilizing Laser Powder Bed Fusion (LPBF) with Haynes 282, the study demonstrated the feasibility of fabricating these heat exchangers at high precision. Post-processing methods, including dilation-erosion operations, were applied to ensure local features adhered to self-supporting constraints. The fabricated structures were then subjected to thermohydraulic testing under conditions representative of supercritical CO 2 Brayton cycles, validating the predicted performance and confirming the viability of the full design-to-fabrication pipeline. Finally, thermohydraulic testing across the above studies served as a crucial experimental validation of advanced heat exchanger. Under consistent high-temperature and high-pressure conditions using supercritical CO 2 , the testing demonstrated that both TO and Gyroid-based TPMS designs significantly outperformed conventional straight-channel HXs. The TO design achieved a 115% increase in UA and NTU and a 27.6% boost in gravimetric power density, while the data-driven optimized Gyroid design delivered a 166% increase in UA and NTU and improved effectiveness from 68.7% to 86.1%. These results validate the simulation models, confirm the manufacturability of complex geometries under AM constraints, and provide key insights into design-performance trade-offs, thereby advancing the development of high-efficiency, compact heat exchangers for extreme environments.

36 MATERIALS SCIENCE↗

Activating a Natural Fault Zone in the Swiss Alps

One major hurdle for understanding earthquake mechanics are observational limitations. Important phenomena like strain localisation, fault dilation, and fault healing are readily studied in rock mechanical laboratory experiments and with numerical models. At the scale of natural earthquakes, however, these phenomena are often unresolvable, even by state-of-the-art observatories. To overcome this limitation, we are currently building the Earthquake Physics Testbed at the Bedretto Underground Laboratory for Geosciences and Geoenergies (BedrettoLab), an experimental testbed where we can activate an extensively instrumented natural fault zone via hydraulic stimulation. The goal of the Fault Activation and Earthquake Rupture (FEAR) project is to induce earthquakes of up to Mw~1.0 on this exceptionally well characterised and instrumented fault zone. Here we summarize the main scientific goals and current FEAR project status, and present first results from conducted experiments. We discuss how this large-scale experimental approach may allow us to tackle both fundamental science as well as practical questions on earthquake physics, induced seismicity and seismic hazard.

Meier, Men-Andrin↗

The Impact of Naphthenic Acids on Dynamic Fluid–Fluid Interactions: Implication for Enhanced Oil Recovery

Previous coreflooding results and wettability analyses in our group show that injection of naphthenic-acid-enriched water can improve oil recovery over traditional waterflooding. This observation is still a subject of research efforts without a definitive explanation. Naphthenic acids (NA) have been reported to drive wettability alteration and increase the water–oil interface elasticity. These alterations depend on the NA carbon number and aqueous-phase salinity, among other conditions, as reported in the literature. Smart-water flooding (SWF) research often links recovery to the initial wettability condition, being higher for initially oil-wet rock. SWF refers to a technique in which the aqueous-phase ion composition or/and salinity are changed to maximize oil recovery. Given NAs’ complex solution behavior, selecting acid combinations that prompt oil recovery is a difficult objective. The aim of this research is to determine the effects of select naphthenic acids on the oil–water interfacial rheology and wettability alteration and how these interfacial effects are associated with oil recovery under spontaneous imbibition. NAs were selected based on their carbon number, molecular structure, and solubility in the saline solution used in this research. We aimed at exploring which NAs should be used to regulate interfacial properties so as to either increase oil recovery or accelerate production. Time-domain nuclear magnetic resonance, interfacial dilatational rheology, and liquid-bridge experiments, i.e., proxy of snap-off, were conducted. A baseline was established using results obtained with a previously tested sulfate-rich aqueous phase, shown to be effective in recovering oil. Results show that NA14 and N18 increase the water–oil interfacial viscoelasticity and induce interfacial healing but led to different recovery factors. N10, while effective at inducing water wetness in oil-wet rock, is ineffective at increasing the recovery factor. We concluded that wettability and oil–water interfacial rheology are not exclusive, and instead they can synergistically favor EOR benefits. Moreover, oil recovery benefits under spontaneous imbibition are shown to depend strongly on the initial wettability conditions.

Medina-Rodriguez, Bryan X. (ORCID:0000000262922831↗

PREFACE: A Search for Long-Lived Particles at the Large Hadron Collider

The Standard Model (SM) fails to explain many problems (neutrino masses, dark matter, and matter–antimatter asymmetry, among others) that may be resolved with new particles beyond the SM. No observation of such new particles may be explained either by their exceptionally high mass or by considerably small coupling to SM particles. The latter case implies relatively long lifetimes. Such long-lived particles (LLPs) then to have signatures different from those of SM particles. Searches in the “central region” are covered by the LHC general purpose experiments. The forward small angle region far from the interaction point (IP) is unexplored. Such particles are expected to have the energy as large as E = O(1 TeV) and Lorentz time dilation factor γ = E/m ≈ 10 2 –10 3 (with m the particle mass) hence long enough decay distances. A new class of specialized LHC detectors dedicated to LLP searches has been proposed for the forward regions. Among these experiments, FASER is already operational, and FACET is under consideration at a location 100 m from the LHC IP5 (the CMS detector intersection). However, some features of FACET require a specially enlarged beam pipe, which cannot be implemented for LHC Run 4. In this study, we explore a simplified version of the proposed detector PREFACE compatible with the standard LHC beam pipe in the HL-LHC Run 4. Realistic G EANT 4 simulations are performed and the background is evaluated. An initial analysis of the physics potential with the PREFACE geometry indicates that several significant channels could be accessible with sensitivities comparable to FACET and other LLP searches.

72 PHYSICS OF ELEMENTARY PARTICLES AND FIELDS↗

Tests of general relativity using pulsars

The arrival times of the pulses from each pulsar are measured by a cesium clock. The observations are all made at a frequency of 2388 MHz (12.5 cm wavelength) on a 26 m dish antenna. The effect of interstellar charged particles is a random one that increases the noise level on the arrival time measurements. The variation in clock rate is shown consisting of two effects: the time dilation effect of special relativity and the red shift effect of general relativity.

Reichley, P. E.↗

Finite element analysis of elasto-plastic soils. Report no. 4: Finite element analysis of elasto-plastic frictional materials for application to lunar earth sciences

The behavior of finite element models employing different constitutive relations to describe the stress-strain behavior of soils is investigated. Three models, which assume small strain theory is applicable, include a nondilatant, a dilatant and a strain hardening constitutive relation. Two models are formulated using large strain theory and include a hyperbolic and a Tresca elastic perfectly plastic constitutive relation. These finite element models are used to analyze retaining walls and footings. Methods of improving the finite element solutions are investigated. For nonlinear problems better solutions can be obtained by using smaller load increment sizes and more iterations per load increment than by increasing the number of elements. Suitable methods of treating tension stresses and stresses which exceed the yield criteria are discussed.

Marr, W. A., Jr.↗

Propagation of the transverse normal stress in a thick plate due to distributed lateral impulsive loadings

A theoretical study of the elastic stresses produced in an infinite plate when struck by a high-speed object is presented. The solution is obtained by means of linear elasticity. Laplace transformation techniques are employed to solve the axisymmetric problem. The plate is loaded normal to its surface with a uniform load over a circular area. The normal stress at the wave front of the unreflected dilatation wave along the axis and its variation with the radius of loading are determined. Various facets of the problem are discussed.

Oline, L. W.↗

Late effects of 2.2 GeV protons on the central nervous system.

Investigation of late pathological effects of high-energy (2.2 GeV) protons on the brain of rabbits, in a postirradiation period of up to 16 months following exposure at fluxes of 30, 100, and 1000 billion protons per sq cm. At the latter two irradiation-intensity levels, the kinds of brain lesions inflicted include large venous dilatation, thickening of vessel walls with deposit of amorphous PAS positive substance, thrombosis, perivascular infiltration of leukocytes and macrophages, mobilization of microglia cells, gliosis, demyelinization, and multiple small pseudocyst formation.

Lippincott, S. W.↗