Engineering Papers⌕ Search

SEARCH · Engineering Papers

Results for “Spine”

Search indexed NASA NTRS and DOE OSTI research on propulsion, heat transfer, battery materials and energy systems. Follow report and document links to the original sources.

Quote a phrase for an exact phrase match. Source license links do not imply unrestricted reuse.

At least 163 records · Page 9
All sourcesNASA NTRSDOE OSTI
NASA NTRS1993

Illness/injury pattern complex 40 (Titan)

On July 31, 1991, EG&G Medical began providing medical support at the Titan Area Clinic (TAC). The hours of operation are 0700-2300, Monday through Friday, with Emergency Medical Services (EMS) provided 24-hours a day, seven days a week. The TAC consists of a 10 x 10 ft section of a trailer that also houses Bechtel Safety. Supplies consisted of an examining table, an eye wash chair, first aid equipment, over-the-counter medications, spine boards, a portable rescuscitator, etc. All of the nurses are Advanced Cardiac Life Support (ACLS) certified. Although the Titan Area Clinic is strictly a first-aid station with no ACLS facilities on-site, it is staffed with an Occupational Health Nurse with ACLS certification. If ACLS or additional help is needed, the nurse activates EMS by dialing 911. The nurse responds to any medical problems or emergencies on the complex, but activates EMS prior to leaving the TAC. A Bechtel Safety Representative accompanies the nurse to the site and assists as needed. Other aspects of the complex and its functions are presented.

Blasdell, Sharon↗
NASA NTRS1995

Mineral distribution in rat skeletons after exposure to a microgravity model

Exposure to space flight models induces changes in the distribution of bone mineral in the human skeleton that has the features of a gravitational gradient. Regional bone mineral measurements with dual energy x-ray absorptiometry (DEXA) in male adults exposed to head-down tilt bed rest for 30 days shown non-significant decrements in the pelvis and legs with 10% increases in the head region. Horizontal bed rest for 17 weeks reveals losses of bone mineral ranging from 2.2 to 10.4% from the lumbar spine to the calcaneus and an increase of 3.4% in the skull. Investigation of this phenomena would be most definitively carried out in an animal model. One candidate is the flight simulation model in the rat which removes body weight from the hind limbs and induces a cephalad fluid shift by suspending the animal by the tail. Weanling rats exposed to this model showed bone mineral to be lower in the hind limbs and higher in the skull after 3 weeks. These finds are similar in older 200 g animals after 2 weeks tail suspension. The purpose of this study was to determine the effect of age on the distribution of skeletal mineral in this model.

Arnaud, Sara B.↗
NASA NTRS1995

Back Pain During 6 deg Head-Down Tilt Approximates That During Actual Microgravity

Astronauts often experience back pain during spaceflight. It was found that during spaceflight, 14 of 19 Shuttle crewmembers experienced back pain, which they described as dull (62%), localized to the lower back (500/6), and with an intensity of 2 on a 5-point scale. Further, the spine lengthens 4-7 cm in microgravity. Our objective was to compare back pain and spinal lengthening (body height increase) during simulated microgravity (6 deg head-down tilt, HDT) with the some parameters during actual microgravity. Eight male subjects completed a modified McGill pain questionnaire with intensity graded from zero (no pain) to five (intense and incapacitating gain) each day at 7.-OO pm during 2 d pre-HDT control, 16 d HDT, and I d post-HDT recovery periods. Only 2 subjects reported any pain after day 9 of HDT and during recov- ery. Heights increased 2.1 t 0.5 cm by day 3 of HDT and re- mained at that level until the end of the HDT period. Although spinal lengthening in space is greater than that during HDT, the HDT model approximates the level, type, distribution, and time course of back pain associated with actual microgrovity. In the HDT model, pain subsides in intensity when spinal lengthening stops. Therefore, back pain in actual and simulated microgravity may result from stretching of spinal andlor paraspinal tissues until a new spinal length is reached.

Karen J. Hutchinson↗
NASA NTRS1996

Gravity Sensor Plasticity in the Space Environment

The ability of the brain to learn from experience and to adapt to new environments is recognized to be profound. This ability, called 'neural plasticity,' depends directly on properties of neurons (nerve cells) that permit them to change in dimension, sprout new parts called spines, change the shape and/or size of existing parts, and to generate, alter, or delete synapses. (Synapses are communication sites between neurons.) These neuronal properties are most evident during development, when evolution guides the laying down of a general plan of the nervous system. However, once a nervous system is established, experience interacts with cellular and genetic mechanisms and the internal milieu to produce unique neuronal substrates that define each individual. The capacity for experience-related neuronal growth in the brain, as measured by the potential for synaptogenesis, is speculated to be in the trillions of synapses, but the range of increment possible for any one part of the nervous system is unknown. The question has been whether more primitive endorgans such as gravity sensors of the inner ear have a capacity for adaptive change, since this is a form of learning from experience.

Ross, Muriel D.↗
NASA NTRS1997

The German/Russian MIR 1997 Mission: An Overview

Session TP4 includes short reports concerning: (1) Life Science Experiments During the German-Russian Mir '97 Mission; (2) Orthostatic Intolerance Following Microgravity: A Role for Autonomic Dysfunction; (3) Heart Rate Variability and Skin Blood Flow in Man During Orthostatic Stress in Weightlessness; (4) Effects of Microgravity and Lower Body Negative Pressure on Circulatory Drives from Excercising Calf Muscles; (5) The Mir Station in Its Second Decade: Crew Science Operation During Mir '97; (6) Metabolic WARD (Water, Sodium, Calcium, and Bone Metabolism) and Endocrinological Experiments During the Mir '97 Mission; (7) Long-term Monitoring of the Spine-geometry During the Mir '97 Mission: Introduction of a New Method; and (8) Effects of 20 days of Microgravity (German/Russian Mir '97 Mission) on the Mechanical and Electromyographic Characteristics of Explosive Efforts of the Lower Limbs and of Cycloergometric Exercises of Mild to Sprint-Like Intensity.

Source record↗
NASA NTRS1998

Vehicle and Mission Design Options for the Human Exploration of Mars/Phobos Using "Bimodal" NTR and LANTR Propulsion

The nuclear thermal rocket (NTR) is one of the leading propulsion options for future human missions to Mars because of its high specific impulse (Isp-850-1000 s) capability and its attractive engine thrust-to-weight ratio (approximately equal 3-10). To stay within the available mass and payload volume limits of a "Magnum" heavy lift vehicle, a high performance propulsion system is required for trans-Mars injection (TMI). An expendable TMI stage, powered by three 15 thousand pounds force (klbf) NTR engines is currently under consideration by NASA for its Design Reference Mission (DRM). However, because of the miniscule burnup of enriched uranium-235 during the Earth departure phase (approximately 10 grams out of 33 kilograms in each NTR core), disposal of the TMI stage and its engines after a single use is a costly and inefficient use of this high performance stage. By reconfiguring the engines for both propulsive thrust and modest power generation (referred to as "bimodal" operation), a robust, multiple burn, "power-rich" stage with propulsive Mars capture and reuse capability is possible, A family of modular "bimodal" NTR (BNTR) vehicles are described which utilize a common "core" stage powered by three 15 klbf BNTRs that produce 50 kWe of total electrical power for crew life support, an active refrigeration / reliquification system for long term, "zero-boiloff" liquid hydrogen (LH 2 ) storage, and high data rate communications. An innovative, spine-like "saddle truss" design connects the core stage and payload element and is open underneath to allow supplemental "in-line" propellant tanks and contingency crew consumables to be easily jettisoned to improve vehicle performance. A "modified" DRM using BNTR transfer vehicles requires fewer transportation system elements, reduces IMLEO and mission risk, and simplifies space operations. By taking the next logical step--use of the BNTR for propulsive capture of all payload elements into Mars orbit--the power available in Mars orbit grows to 150 kWe compared to 30 kWe for the DRM. Propulsive capture also eliminates the complex, higher risk aerobraking and capture maneuver which is replaced by a simpler reentry using a standardized, lower mass "aerodescent" shell. The attractiveness of the "all BNTR" option is further increased by the substitution of the lightweight, inflatable "TransHab" module in place of the heavier, hard-shell hab module. Use of TransHab introduces the potential for propulsive recovery and reuse of the BNTR/ERV. It also allows the crew to travel to and from Mar on the same BNTR transfer vehicle thereby cutting the duration of the ERV mission in half--from approximately 4.7 to 2.5 years. Finally, for difficult Mars options, such as Phobos rendezvous and sample return missions, volume (not mass) constraints limit the performance of the "all LH 2 " BNTR stage. The use of "LOX-augmented" NTR (LANTR) engines, operating at a modest oxygen-to-hydrogen mixutre ratio (MR) of 0.5, helps to increase "bulk" propellant density and total thrust during the TMI burn. On all subsequent burns, the bimodal LANTR engines operate on LH 2 only (MR=0) to maximize vehicle performance while staying within the lift capability of two Magnum launches.

Nuclear thermal rocket↗
NASA NTRS1999

Computer Aided Modeling to Determine the Effectiveness of Resistive Exercises as Countermeasures for Bone Mineral Density Loss

Due to the loss of gravitational loading, astronauts have a tendency to lose bone mineral density in their lumbar spine and lower extremities on orbit. NASA requires astronauts to perform exercises during space flight to help reduce the amount of demineralization. To test these exercises on earth, 17 week bed rest studies are conducted that consist of specific diet and exercise regimes. Developing a finite element model of these exercises will help to quantify the stress distribution imposed by of each of these exercises. To help develop this model, MRI images are acquired from individuals participating in the bed rest studies. The MRIs can be used to create a subject specific model of each individual for testing. The MRIs are processed in the Magnetic Resonance Imaging Data Transfer System program to develop a three-dimensional finite element model of the femur for evaluation. Modifications were made to the MRIDTS that simplified the model creation process. These modifications made it possible to construct two separate models of different portions of a bone simultaneously and then later connect them manually. This helped alleviate the warping problem associated with the drastic changes in geometry found in some body parts, such as the joints. The code was also modified to incorporate material properties of various bone components into the model. Interior meshing was also incorporated into the program to allow for both the cortical shell and the entire bone to be modeled. A prototype model of the right femur of an adult female is being constructed and tested to determine the feasibility of finite element analysis as a tool for evaluating exercise effectiveness. The model is being run through the ANSYS finite element program on the Alabama Super Computer Network. After the model is validated, models of bedrest subjects can be generated to investigate exercise countermeasures.

Murphy, Benjamin M.↗
NASA NTRS2001

STS-102 Mission Highlight Resource Tape, Tape 1 of 4

This video gives an overview of the first four flight days of the STS-102 mission through a compilation of footage from each day. The crew of STS-102 (Commander James Wetherbee, Pilot James Kelly, and Mission Specialists Andrew Thomas and Paul Richards) and the Expedition 2 crew (Commander Yuriy Usachev and Flight Engineers James Voss and Susan Helms) are seen during the ceremonial breakfast, suitup, and as they board Discovery. The orbiter's launch is seen from several different viewpoints, and various in-flight activities are shown, such as the opening of Discovery's payload bay doors, Helms preparing for the 'H-Reflex Experiment: Effects of Microgravity on the Spine', the rendezvous and docking of Discovery with the International Space Station (ISS), and Helms and Voss preparing for and performing their spacewalks. The crew of STS-102 and both Expedition crews (E1 crew William Shepherd, Yuri Gidzenko, and Sergei Krikalev) are seen in the Destiny Laboratory Module. Activities for flight day five can be seen on 'STS-102 Mission Highlight Resource Tape, Part 1 of 2, Tape 2 of 2' (internal ID 2001096941). Flight days 6-14 activities can be seen on 'STS-102 Mission Highlight Resource Tape, Part 2 of 2, Tape 1 of 2' (internal ID 2001096943) and 'STS-102 Mission Highlight Resource Tape, Part 2 of 2, Tape 2 of 2' (internal ID 2001096940).

Source record↗
NASA NTRS1984

New Help for the Handicapped

L & M Electronics, Inc.'s telemetry system is used to measure degree and location of abnormal muscle activity. This telemetry was originally used to monitor astronauts vital functions. Leg sensors send wireless signals to computer which develops pictures of gait patterns. System records, measures and analyzes muscle activities in limbs and spine. Computer developed pictures of gait patterns help physicians determine potential of corrective surgery, evaluate various types of braces, or decide whether physical therapy may improve motor functions.

Source record↗
NASA NTRS2002

From Milk to Bones, Moving Calcium Through the Body: Calcium Kinetics During Space Flight

Did you know that when astronauts are in space, their height increases about two inches? This happens because the weightlessness of space allows the spine, usually compressed in Earth's gravity, to expand. While this change is relatively harmless, other more serious things can happen with extended stays in weightlessness, notably bone loss. From previous experiments, scientists have observed that astronauts lose bone mass at a rate of about one percent per month during flight. Scientists know that bone is a dynamic tissue - continually being made and repaired by specialized bone cells throughout life. Certain cells produce new bone, while other cells are responsible for removing and replacing old bone. Research on the mechanisms of bone metabolism and the effects of space flight on its formation and repair are part of the exciting studies that will be performed during STS-107. Calcium plays a central role because 1) it gives strength and structure to bone and 2) all types of cells require it to function normally. Ninety-nine percent of calcium in the body is stored in the skeleton. However, calcium may be released, or resorbed, from bone to provide for other tissues when you are not eating. To better understand how and why weightlessness induces bone loss, astronauts will participate in a study of calcium kinetics - that is, the movement of calcium through the body, including absorption from food, and its role in the formation and breakdown of bone.

Scott Smith↗
NASA NTRS2002

Vehicle and Mission Design Options for the Human Exploration of Mars/Phobos Using "Bimodal" NTR and LANTR Propulsion

The nuclear thermal rocket (NTR) is one of the leading propulsion options for future human missions to Mars because of its high specific impulse (lsp~850-1000 s) capability and its attractive engine thrust-to-weight ratio (~3-10). To stay within the available mass and payload volume limits of a “Magnum” heavy lift vehicle, a high performance propulsion system is required for trans-Mars injection (TMI). An expendable TMI stage, powered by three 15 thousand pounds force (klbf) NTR engines is currently under consideration by NASA for its Design Reference Mission (DRM). However, because of the miniscule burnup of enriched uranium-235 during the Earth departure phase (~10 grams out of 33 kilograms in each NTR core), disposal of the TMI stage and its engines after a single use is a costly and inefficient use of this high performance stage. By reconfiguring the engines for both propulsive thrust and modest power generation (referred to as “bimodal” operation), a robust, multiple burn, “power-rich” stage with propulsive Mars capture and reuse capability is possible. A family of modular “bimodal” NTR (BNTR) vehicles are described which utilize a common “core” stage powered by three 15 klbf BNTRs that produce 50 kWe of total electrical power for crew life support, an active refrigeration / reliquification system for long term, zero-boiloff liquid hydrogen (LH 2 ) storage, and high data rate communications. An innovative, spine-like “saddle truss” design connects the core stage and payload element and is open underneath to allow supplemental “in-line” propellant tanks and contingency crew consumables to be easily jettisoned to improve vehicle performance. A “modified” DRM using BNTR transfer vehicles requires fewer transportation system elements, reduces IMLEO and mission risk, and simplifies space operations. By taking the next logical step—use of the BNTR for propulsive capture of all payload elements into Mars orbit—the power available in Mars orbit grows to 150 kWe compared to 30 kWe for the DRM. Propulsive capture also eliminates the complex, higher risk aerobraking and capture maneuver which is replaced by a simpler reentry using a standardized, lower mass “aerodescent” shell. The attractiveness of the “all BNTR” option is further increased by the substitution of the lightweight, inflatable “TransHab” module in place of the heavier, hard-shell hab module. Use of TransHab introduces the potential for propulsive recovery and reuse of the BNTR / Earth return vehicle (ERV). It also allows the crew to travel to and from Mars on the same BNTR transfer vehicle thereby cutting the duration of the ERV mission in half—from ~4.7 to 2.5 years. Finally, for difficult Mars options, such as Phobos rendezvous and sample return missions, volume (not mass) constraints limit the performance of the “all LH 2 ” BNTR stage. The use of “LOX-augmented” NTR (LANTR) engines, operating at a modest oxygen-to-hydrogen mixture ratio (MR) of 0.5, helps to increase “bulk” propellant density and total thrust during the TMI burn. On all subsequent burns, the bimodal LANTR engines operate on LH 2 only (MR=0) to maximize vehicle performance while staying within the mass limits of two Magnum launches.

Nuclear thermal rocket↗
NASA NTRS2002

RHESSI and Trace Observations of the 21 April 2002 X1.5 Flare

Observations of the X1.5 flare on 21 April 2002 are reviewed using the Ramaty High Energy Solar Spectroscopic Imager (RHESSI) and the Transition Region and Coronal Explorer (TRACE). The major findings are as follows: 1. The 3-25 keV X-rays started 54 mins before the EUV (195 A) emission suggesting that the initial energy release heated plasma directly to 220 MK, well above the 1.6 MK needed to produce the Fe XII (195 A) line. 2. Using coaligned 12-25 keV RHESSI and TRACE images, further evidence is found for the existence of hot (15-20 MK) plasma in the 195 A passband. This hot, diffuse emission is attributed to the presence of the Fe XXIV (192 A) line within the TRACE 195 A passband. 3. The 12-25 keV source centroid moves away from the limb with an apparent velocity of approx. 9.9 km/ s, slowing to approx. 1.7 km/ s after 3 hours, its find altitude being approx. 120 Mm after approx. 12 hours. This suggests that the energy release site moves to higher altitudes in agreement with classical flare models. 4. The 50-100 keV emission correlates well with EUV flare ribbons, suggesting thick-target interactions at the footpoints of the magnetic arcade. The 50-100 keV time profile matches the time derivative of the GOES light curve (Neupert effect), which suggests that the same electrons that produced the thick-target hard X-ray emission also heat the plasma seen in soft X-rays. 5. X-ray footpoint emission has an E(sup -3) spectrum down to approx. 10 keV suggesting a lower electron cutoff energy than previously thought. 6. The hard X-ray (25-200 keV) peaks have FWHM durations of approx. 1 min suggesting a more gradual energy release process than expected. 7. The TRACE images reveal a bright symmetric front propagating away from the main flare site at speeds of greater than or = 120 km/ s. This may be associated with fast CME observed several minutes later by LASCO. 8. Dark sinuous lanes are observed in the TRACE images that extend almost radially from the post-flare loop system. This "fan of spines" becomes visible well into the decay phase of the flare and shows evidence for both lateral and downward motions.

Gallagher, Peter T.↗
NASA NTRS2004

Biophotonics and Bone Biology

One of the more serious side effects of extended space flight is an accelerated bone loss. Rates of bone loss are highest in the weight-bearing bones of the hip and spine regions, and the average rate of bone loss as measured by bone mineral density measurements is around 1.2% per month for persons in a microgravity environment. It is well known that bone remodeling responds to mechanical forces. We are developing two-photon microscopy techniques to study bone tissue and bone cell cultures to better understand the fundamental response mechanism in bone remodeling. Osteoblast and osteoclast cell cultures are being studied, and the goal is to use molecular biology techniques in conjunction with Fluorescence Lifetime Imaging Microscopy (FLIM) to study the physiology of in-vitro cell cultures in response to various stimuli, such as fluid flow induced shear stress and mechanical stress. We have constructed a two-photon fluorescence microscope for these studies, and are currently incorporating FLIM detection. Current progress will be reviewed. This work is supported by the NASA John Glenn Biomedical Engineering Consortium.

Zimmerli, Gregory↗
NASA NTRS2001

Biology of bone and how it orchestrates the form and function of the skeleton

The principal role of the skeleton is to provide structural support for the body. While the skeleton also serves as the body's mineral reservoir, the mineralized structure is the very basis of posture, opposes muscular contraction resulting in motion, withstands functional load bearing, and protects internal organs. Although the mass and morphology of the skeleton is defined, to some extent, by genetic determinants, it is the tissue's ability to remodel--the local resorption and formation of bone--which is responsible for achieving this intricate balance between competing responsibilities. The aim of this review is to address bone's form-function relationship, beginning with extensive research in the musculoskeletal disciplines, and focusing on several recent cellular and molecular discoveries which help understand the complex interdependence of bone cells, growth factors, physical stimuli, metabolic demands, and structural responsibilities. With a clinical and spine-oriented audience in mind, the principles of bone cell and molecular biology and physiology are presented, and an attempt has been made to incorporate epidemiologic data and therapeutic implications. Bone research remains interdisciplinary by nature, and a deeper understanding of bone biology will ultimately lead to advances in the treatment of diseases and injuries to bone itself.

Review↗
NASA NTRS1996

Expression of spicule matrix protein gene SM30 in embryonic and adult mineralized tissues of sea urchin Hemicentrotus pulcherrimus

We have isolated a cDNA clone for spicule matrix protein, SM30, from sea urchin Hemicentrotus pulcherrimus and have studied the expression of this gene in comparison with that of another spicule matrix protein gene, SM50. In cultured micromeres as well as in intact embryos transcripts of SM30 were first detectable around the onset of spicule formation and rapidly increased with the growth of spicules, which accompanied accumulation of glycosylated SM30 protein(s). When micromeres were cultured in the presence of Zn2+, spicule formation and SM30 expression were suppressed, while both events resumed concurrently after the removal of Zn2+ from the culture medium. Expression of SM50, in contrast, started before the appearance of spicules and was not sensitive to Zn2+. Differences were also observed in adult tissues; SM30 mRNA was detected in spines and tube feet but not in the test, while SM50 mRNA was apparent in all of these mineralized tissues at similar levels. These results strongly suggest that the SM30 gene is regulated by a different mechanism to that of the SM50 gene and that the products of these two genes are differently involved in sea urchin biomineralization. A possible role of SM30 protein in skeleton formation is discussed.

NASA Discipline Musculoskeletal↗
NASA NTRS1998

The effects of twelve weeks of bed rest on bone histology, biochemical markers of bone turnover, and calcium homeostasis in eleven normal subjects

This study was undertaken to examine the effects of 12 weeks of skeletal unloading on parameters of calcium homeostasis, calcitropic hormones, bone histology, and biochemical markers of bone turnover in 11 normal subjects (9 men, 2 women; 34 +/- 11 years of age). Following an ambulatory control evaluation, all subjects underwent 12 weeks of bed rest. An additional metabolic evaluation was performed after 12 days of reambulation. Bone mineral density declined at the spine (-2.9%, p = 0.092) and at the hip (-3.8%, p = 0.002 for the trochanter). Bed rest prompted a rapid, sustained, significant increase in urinary calcium and phosphorus as well as a significant increase in serum calcium. Urinary calcium increased from a pre-bed rest value of 5.3 mmol/day to values as high as 73 mmol/day during bed rest. Immunoreactive parathyroid hormone and serum 1,25-dihydroxyvitamin D declined significantly during bed rest, although the mean values remained within normal limits. Significant changes in bone histology included a suppression of osteoblastic surface for cancellous bone (3.1 +/- 1.3% to 1.9 +/- 1.5%, p = 0.0142) and increased bone resorption for both cancellous and cortical bone. Cortical eroded surface increased from 3.5 +/- 1.1% to 7.3 +/- 4.0% (p = 0.018) as did active osteoclastic surface (0.2 +/- 0.3% to 0.7 +/- 0.7%, p = 0.021). Cancellous eroded surface increased from 2.1 +/- 1.1% to 4.7 +/- 2.2% (p = 0.002), while mean active osteoclastic surface doubled (0.2 +/- 0.2% to 0.4 +/- 0.3%, p = 0.020). Serum biochemical markers of bone formation (osteocalcin, bone-specific alkaline phosphatase, and type I procollagen extension peptide) did not change significantly during bed rest. Urinary biochemical markers of bone resorption (hydroxyproline, deoxypyridinoline, and N-telopeptide of type I collagen) as well as a serum marker of bone resorption (type I collagen carboxytelopeptide) all demonstrated significant increases during bed rest which declined toward normal during reambulation. Thus, under the conditions of this study, the human skeleton appears to respond to unloading by a rapid and sustained increase in bone resorption and a more subtle decrease in bone formation.

NASA Discipline Musculoskeletal↗
NASA NTRS2004

Biophotonics and Bone Biology

One of the more-serious side effects of extended space flight is an accelerated bone loss [Bioastronautics Critical Path Roadmap, http://research.hq.nasa.gov/code_u/bcpr/index.cfm]. Rates of bone loss are highest in the weight-bearing bones of the hip and spine regions, and the average rate of bone loss as measured by bone mineral density measurements is around 1.2% per month for persons in a microgravity environment. It shows that an extrapolation of the microgravity induced bone loss rates to longer time scales, such as a 2.5 year round-trip to Mars (6 months out at 0 g, 1.5 year stay on Mars at 0.38 g, 6 months back at 0 g), could severely compromise the skeletal system of such a person.

Zimmerli, Gregory↗
NASA NTRS1998

Future human bone research in space

Skylab crewmembers demonstrated negative calcium (Ca) balance reaching about -300 mg/day by flight day 84. Limited bone density (BMD) measurements documented that bone was not lost equally from all parts of the skeleton. Subsequent BMD studies during long duration Russian flights documented the regional extent of bone loss. These studies demonstrated mean losses in the spine, femur neck, trochanter, and pelvis of about 1%-1.6% with large differences between individuals as well as between bone sites in a given individual. Limited available data indicate postflight bone recovery occurred in some individuals, but may require several years for complete restoration. Long duration bedrest studies showed a similar pattern of bone loss and calcium balance (-180 mg/day) as spaceflight. During long duration bedrest, resorption markers were elevated, formation markers were unchanged, 1,25 vitamin D (VitD) and calcium absorption were decreased, and serum ionized Ca was increased. Although this information is a good beginning, additional spaceflight research is needed to assess architectural and subregional bone changes, elucidate mechanisms, and develop efficient as well as effective countermeasures. Space research poses a number of unique problems not encountered in ground-based laboratory research. Therefore, researchers contemplating human spaceflight research need to consider a number of unique problems related to spaceflight in their experimental design.

NASA Center JSC↗