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At least 163 records · Page 9
All sourcesNASA NTRSDOE OSTI
NASA NTRS2008

Chromosome Aberration in Human Blood Lymphocytes Exposed to Energetic Protons

During space flight, astronauts are exposed to a space radiation consisting of high-energy protons, high charge and energy (HZE) nuclei, as well as secondary particles that are generated when the primary particles penetrate the spacecraft shielding. Secondary particles have a higher LET value than primary protons and therefore expected to have a higher relative biological effectiveness (RBE). To investigate this theory, we exposed human peripheral blood lymphocytes to protons with energies of 250 MeV, 800MeV, 2 GeV, or 2.5 GeV. LET values for these protons ranged from 0.4 to 0.2 keV/micrometer. and doses ranged from 0.2 to 3 Gy. Over this energy the probability of nuclear reaction leading to secondary radiation, and the multiplicity of reaction produces such as neutrons and mesons increases substantially. The effect of aluminum and polyethylene shielding was also assessed using the 2 GeV and 2.5GeV proton beams. After exposure lymphocytes were stimulated to divide and chromosomes were collected from cells in the first G2 and metaphase cell cycle after exposure using a chemical induced premature chromosome condensation (PCC) technique. Dose response data for chromosome damage was analyzed using the fluorescence in situ hybridization (FISH) chromosome painting technique. Selected samples were also analyzed with multicolor FISH (mFISH) and multicolor banding FISH (mBAND) techniques. Data indicates that the dose response for simple-type exchanges is similar for proton and gamma exposure, whereas protons induce higher yields of complex exchanges that are LET dependent. RBE values will be presented for each proton energy, and the effects of shielding and possible cytogenetic signatures of proton exposure will be discussed.

Hada, M.↗
NASA NTRS2005

In Vitro Experimental Model to Investigate the Biological Effects across the Bragg Curve of High-LET Radiation

The space environment consists of a varying field of radiation particles including high energy ions, with a spacecrafts shielding material providing the only major protection to astronauts from harmful exposure. Unlike lowLET gamma or Xrays, the presence of shielding does not always reduce the radiation risks for energetic charged particle exposure since the dose delivered by the charged particle increases sharply as the particle approaches the end of its range, a position known as the Bragg peak and the correlating spatial dose distribution identified as the Bragg curve. The Bragg curve does not necessarily represent the biological damage along the particle traversal since biological effects are influenced by the track structure of both primary and secondary particles. Therefore, the biological Bragg curve is dependent of the energy and the type of the primary particle, and may vary for different biological endpoints. Here we describe a unique irradiation geometry and experimental system to measure the biological response across the Bragg curve in one consistent biological sample. Polyethylene shielding was used to achieve a Bragg curve distribution with the beam geometry parallel to a monolayer of fibroblast cells. We present data that highlights the differential formation of DNA double strand breaks (DSBs) and chromosomal deletions across the Bragg curve in human fibroblasts irradiated with 600 MeV/nucleon iron ion beams. Qualitative analyses of gammaH2AX fluorescence, a known marker of DSBs, indicated potentially increased clustering of DNA damage before the Bragg peak, enhanced homogenous distribution at the peak, and provided visual evidence of high linear energy transfer (LET) particle traversal of cells beyond the Bragg peak in agreement with one-dimensional transport approximations. A biological response curve generated for micronuclei induction across the Bragg curve for 600 MeV/n Fe ions did not reveal an increase in the yield of micronuclei at the Bragg peak location. Assessment of such biological parameters employing the described in vitro experimental system may provide improved platforms to measure a number of biological consequences of shielding materials across the Bragg curve for high charge and energy (HZE) ions.

Desai, N.↗
NASA NTRS2006

Induction of Micronuclei in Human Fibroblasts across the Bragg Curve of Energetic Si and Fe Ions

The space environment consists of a varying field of radiation particles including high-energy ions, with spacecraft shielding material providing the major protection to astronauts from harmful exposure. Unlike low-LET gamma or X-rays, the presence of shielding does not always reduce the radiation risks for energetic charged particle exposure. Since the dose delivered by the charged particle increases sharply as the particle approaches the end of its range, a position known as the Bragg peak, the Bragg curve does not necessarily represent the biological damage along the particle traversal since biological effects are influenced by the track structure of both primary and secondary particles. Therefore, the biological Bragg curve is dependent on the energy and the type of the primary particle, and may vary for different biological endpoints. We studied micronuclei (MN) induction across the Bragg curve of Si and Fe ions at incident energies of 300 MeV/nucleon and 1 GeV/nucleon. A quantitative biological response curve did not reveal an increased yield of MN at the location of the Bragg peak. However, the ratio of mono- to bi-nucleated cells, which indicates inhibition in cell progression, increased at the Bragg peak location. These results confirm the hypothesis that severely damaged cells at the Bragg peak are likely to go through reproduction death.

Wu, H.↗
NASA NTRS2009

Development of a GCR Event-based Risk Model

A goal at NASA is to develop event-based systems biology models of space radiation risks that will replace the current dose-based empirical models. Complex and varied biochemical signaling processes transmit the initial DNA and oxidative damage from space radiation into cellular and tissue responses. Mis-repaired damage or aberrant signals can lead to genomic instability, persistent oxidative stress or inflammation, which are causative of cancer and CNS risks. Protective signaling through adaptive responses or cell repopulation is also possible. We are developing a computational simulation approach to galactic cosmic ray (GCR) effects that is based on biological events rather than average quantities such as dose, fluence, or dose equivalent. The goal of the GCR Event-based Risk Model (GERMcode) is to provide a simulation tool to describe and integrate physical and biological events into stochastic models of space radiation risks. We used the quantum multiple scattering model of heavy ion fragmentation (QMSFRG) and well known energy loss processes to develop a stochastic Monte-Carlo based model of GCR transport in spacecraft shielding and tissue. We validated the accuracy of the model by comparing to physical data from the NASA Space Radiation Laboratory (NSRL). Our simulation approach allows us to time-tag each GCR proton or heavy ion interaction in tissue including correlated secondary ions often of high multiplicity. Conventional space radiation risk assessment employs average quantities, and assumes linearity and additivity of responses over the complete range of GCR charge and energies. To investigate possible deviations from these assumptions, we studied several biological response pathway models of varying induction and relaxation times including the ATM, TGF -Smad, and WNT signaling pathways. We then considered small volumes of interacting cells and the time-dependent biophysical events that the GCR would produce within these tissue volumes to estimate how GCR event rates mapped to biological signaling induction and relaxation times. We considered several hypotheses related to signaling and cancer risk, and then performed simulations for conditions where aberrant or adaptive signaling would occur on long-duration space mission. Our results do not support the conventional assumptions of dose, linearity and additivity. A discussion on how event-based systems biology models, which focus on biological signaling as the mechanism to propagate damage or adaptation, can be further developed for cancer and CNS space radiation risk projections is given.

Cucinotta, Francis A.↗
NASA NTRS2002

Monte Carlo Simulation of Spacecraft Particle Detectors to Assess the True Human Risk

Particle detectors (DOSTEL, CPDS, and TEPC) measure the energy deposition spectrum inside earth orbiting - manned spacecraft (shuttle, space station). These instruments attempt to emulate the deposition of energy in human tissue to evaluate the health risk. However, the measurements are often difficult to relate to tissue equivalent because nuclear fragmentation (internuclear cascade/evaporation), energy-loss straggling, heavy ions, spacecraft shielding and detector geometry/orientation, and coincidence thresholds significantly affect the measured spectrum. 'A le have developed a high fidelity Monte Carlo model addressing each of these effects that significantly improves interpretation of these instruments and the resulting assessment of radiation risk to humans.

O'Neill, Patrick M.↗
NASA NTRS2014

Comparison of Model Calculations of Biological Damage from Exposure to Heavy Ions with Measurements

The space environment consists of a varying field of radiation particles including high-energy ions, with spacecraft shielding material providing the major protection to astronauts from harmful exposure. Unlike low-LET gamma or X rays, the presence of shielding does not always reduce the radiation risks for energetic charged-particle exposure. Dose delivered by the charged particle increases sharply at the Bragg peak. However, the Bragg curve does not necessarily represent the biological damage along the particle path since biological effects are influenced by the track structures of both primary and secondary particles. Therefore, the ''biological Bragg curve'' is dependent on the energy and the type of the primary particle and may vary for different biological end points. Measurements of the induction of micronuclei (MN) have made across the Bragg curve in human fibroblasts exposed to energetic silicon and iron ions in vitro at two different energies, 300 MeV/nucleon and 1 GeV/nucleon. Although the data did not reveal an increased yield of MN at the location of the Bragg peak, the increased inhibition of cell progression, which is related to cell death, was found at the Bragg peak location. These results are compared to the calculations of biological damage using a stochastic Monte-Carlo track structure model, Galactic Cosmic Ray Event-based Risk Model (GERM) code (Cucinotta, et al., 2011). The GERM code estimates the basic physical properties along the passage of heavy ions in tissue and shielding materials, by which the experimental set-up can be interpreted. The code can also be used to describe the biophysical events of interest in radiobiology, cancer therapy, and space exploration. The calculation has shown that the severely damaged cells at the Bragg peak are more likely to go through reproductive death, the so called "overkill".

Kim, Myung-Hee Y.↗
NASA NTRS2015

Galactic Cosmic Ray Simulation at the NASA Space Radiation Laboratory

The external Galactic Cosmic Ray (GCR) spectrum is significantly modified when it passes through spacecraft shielding and astronauts. One approach for simulating the GCR space radiation environment at ground based accelerators would use the modified spectrum, rather than the external spectrum, in the accelerator beams impinging on biological targets. Two recent workshops have studied such GCR simulation. The first workshop was held at NASA Langley Research Center in October 2014. The second workshop was held at the NASA Space Radiation Investigators' workshop in Galveston, Texas in January 2015. The results of these workshops will be discussed in this paper.

Norbury, John W.↗
NASA NTRS2015

International Collaboration for Galactic Cosmic Ray Simulation at the NASA Space Radiation Laboratory

An international collaboration on Galactic Cosmic Ray (GCR) simulation is being formed to make recommendations on how to best simulate the GCR spectrum at ground based accelerators. The external GCR spectrum is significantly modified when it passes through spacecraft shielding and astronauts. One approach for simulating the GCR space radiation environment at ground based accelerators would use the modified spectrum, rather than the external spectrum, in the accelerator beams impinging on biological targets. Two recent workshops have studied such GCR simulation. The first workshop was held at NASA Langley Research Center in October 2014. The second workshop was held at the NASA Space Radiation Investigators' workshop in Galveston, Texas in January 2015. The anticipated outcome of these and other studies may be a report or journal article, written by an international collaboration, making accelerator beam recommendations for GCR simulation. This poster describes the status of GCR simulation at the NASA Space Radiation Laboratory and encourages others to join the collaboration.

Norbury, John W.↗
NASA NTRS2015

Galactic Cosmic Ray Simulator at the NASA Space Radiation Laboratory

The external Galactic Cosmic Ray (GCR) spectrum is significantly modified when it passes through spacecraft shielding and astronauts. One approach for simulating the GCR space radiation environment is to attempt to reproduce the unmodified, external GCR spectrum at a ground based accelerator. A possibly better approach would use the modified, shielded tissue spectrum, to select accelerator beams impinging on biological targets. NASA plans for implementation of a GCR simulator at the NASA Space Radiation Laboratory (NSRL) at Brookhaven National Laboratory will be discussed.

Norbury, John W.↗
NASA NTRS2018

Multi-Scale Modeling of Low-Density Carbon-Phenolic Ablators

Protecting a spacecraft during atmospheric entry is one of highest risk factors that needs to be mitigated during design of a space exploration mission. At entry speeds from space, air turns into high-temperature plasma, and spacecraft Thermal Protection Systems (TPS) are needed to protect the vehicle payload. Modern successful material architectures of spacecraft shields use a porous carbon fiber substrate impregnated with phenolic as an ablator material. In the lecture, efforts to build a Predictive Material Modeling framework for porous ablators from micro-scale to macro-scale will be presented. Several numerical methods and techniques will be summarized that use voxelized images to compute geometrical properties of the porous substrate. These computed properties include porosity, specific surface area and tortuosity that are otherwise indirectly measured through experimental techniques. Direct simulation Monte Carlo (DSMC), a particle-based method for approximating the Boltzmann equation, is used to compute the permeability coefficient of the porous substrate based on its digitized representation. The method computes the flow within the microstructure, where the size of the pores may approach the mean-free-path of the flow. Finally, a high-fidelity model implemented in PATO (Porous-material Analysis Toolbox) is discussed, and some examples of ablative material response are presented, including for the first time 3D simulations of the full tiled heat shield for the Mars Science Laboratory (MSL) capsule.

Ablators↗
NASA NTRS2024

Commercial Crew Program (CCP) Post-flight Reference Radiation Environments

The Nowcast of Aerospace Ionizing RAdiation System (NAIRAS) model version 3 is a coupled physics-based model that transports ionizing radiation through the heliosphere, Earth’s magnetosphere, the neutral atmosphere, and aircraft and spacecraft shielding. Ionizing radiation sources included in the model are: 1) galactic cosmic rays, 2) solar energetic particles including protons and heavy ions, and 3) the inner radiation belt trapped protons and electrons. NAIRAS predicts dosimetric quantities and differential and integral flux and fluence quantities for assessing human radiation exposure and single event effects in vehicle electronic systems from the Earth’s surface to the space environment.

Christopher J Mertens↗
NASA NTRS1995

Spacecraft ceramic protective shield

A low areal density protective shield apparatus, and method for making same, for protecting spacecraft structures from impact with hypervelocity objects, including a bumper member comprising a bumper ceramic layer, a bumper shock attenuator layer, and a bumper confining layer. The bumper ceramic layer can be SiC or B.sub.4 C; the bumper shock attenuator layer can be zirconia felt; and the bumper confining layer can be aluminum. A base armor member can be spaced from the bumper member and a ceramic fiber-based curtain can be positioned between the bumper and base armor members.

Larriva, Rene F.↗
NASA NTRS1981

Spacecraft mission and shielding thermal study for a space-storable fluorine-hydrazine propulsion system

The thermal management and shielding problems related to a space-storable fluorine-hydrazine propulsion system are investigated. The general configuration of a space storable propulsion spacecraft and three types of shield configurations are described in detail. An advanced MLI shielding design is proposed showing good agreement with test data. All examined shield configurations were found to be acceptable for inner as well as outer planetary missions. However, for the latter small local heaters may be required to maintain the fluorine above a minimum required temperature of approximately -350 F. The fluorine/hydrazine system with a 25 percent higher specific impulse than the conventionally used propulsion systems, was suggested for interplanetary missions that require substantial velocity changes.

Jones, J. A.↗
NASA NTRS2020

Polyvinyl Alcohol and Medium Density Polyethylene Composite Materials for Neutron Radiation Shielding

Manned spacecraft venturing beyond the Earth’s Van Allen Belts will be subjected to high levels of radiation from both energetic particles emanating from the sun and from galactic atomic events, such as supernovae. The metal shell of a spacecraft offers some protection from gamma radiation and high energy particles originating from both the sun and cosmic sources. The interaction of these high energy particles and radiation with the spacecraft hull create secondary radiation and neutrons, additional hazards for astronauts and electronic systems. Shielding of neutrons is the most challenging of the high energy radiation, since neutrons have zero charge and are least affected by electrical fields, magnetic fields, and atomic forces. Previous studies showed that polyethylene is an effective neutron shielding material, due to its high hydrogen content. High energy neutrons are slowed to thermal neutrons through multiple collisions with the hydrogen atoms, increasing the effectiveness of neutron capture by boron-10 atoms. This study discusses the fabrication and testing of polyvinyl alcohol (PVOH) samples as a neutron shielding material, with comparison to medium density polyethylene (MDPE) composite samples to be used for neutron shielding for spacecraft. PVOH, an aqueous polymer, was chosen for hydrogen content and for enabling the use of organic reinforcement such as cellulose for secondary structural composites. OLTARIS (On-Line Tool for the Assessment of Radiation in Space) was used for radiation shielding simulation and compared with experimental data. Modeling indicates that the most effective shielding from radiation was in an aluminum layer backed by a polymer layer, either MDPE or PVOH. Cross-linked PVOH was also included in the OLTARIS modeling. All 3 polymer cases showed shielding improvement over aluminum alone, with similar dose equivalent reduction for galactic cosmic radiation(GCR)and for radiation from a solar particle event (SPE). Fourier Transform Infrared (FTIR) Spectroscopy was used to confirm the cross-linking in the PVOH sample and to determine the uniformity through the thickness. PVOH, cross-linked PVOH, and MDPE samples were tested for neutron shielding effectiveness using a 1 curie Americium-Beryllium neutron source. Test results indicated the most shielding in the cross-linked PVOH, followed by the pristine PVOH, and MDPE. Neutron testing suggests that polyvinyl alcohol is a good alternative to polyethylene for neutron shielding. The neutron shielding materials, PVOH and cross-linked PVOH developed under this research will enable the safe operation of spacecraft beyond the Earth’s protective Van Allen Radiation Belts. It will be crucial for NASA’s manned missions to the Moon or Mars to protect the health of astronauts and equipment from the harmful effects of excessive radiation.

neutron, shielding, radiation, polyvinyl alcohol, ↗
NASA NTRS2019

A Proposal for Standardized MMOD Shielding for Robotic Spacecraft

NASA robotic spacecraft are required to assess the potential for small debris induced failure for all disposal-critical components. Additional shielding might then be necessary in order to meet the acceptable risk requirement for the overall mission. Traditionally this requirement had been met with little or no additional shielding. Since the introduction of a high density debris population in ORDEM 3.0, some missions, especially those in higher portions of Low Earth Orbit, have needed additional MMOD-specific shielding in order for the mission to meet the requirement. This is a costly design effort when performed late in the project life cycle, which adds unexpected mass to the spacecraft components during the integration phase, and could disrupt thermal management.A proposal is discussed to develop a more cost-effective approach to MMOD-shielding, which can be employed earlier in the hardware design phase. The development and adoption of standardized shielding assemblies allows early tailoring of the shielding around a component, so that the mass is accounted for, as well as the small particle penetration risk, at a point in the design phase when the cost and schedule impact are more manageable. A set of several assemblies can be developed with a range of protection thresholds, in order to control mass where less shielding is needed. Such shielding assemblies would be developed in collaboration with blanket assembly specialists and thermal control engineers to ensure manufacturability and thermal performance challenges are known and acceptable. One clear benefit of such an approach is that hypervelocity testing can be performed on each of the standard shield assemblies to refine and confirm their performance prior to use.The challenges inherent in designing supplemental MMOD shielding will be discussed, including variations in the orbital debris environment and performance prediction. The benefits of a standardized shielding approach and example applications will also be presented.

Hull, Scott M.↗
NASA NTRS2019

A Proposal for Standardized MMOD Shielding for Robotic Spacecraft

NASA robotic spacecraft are required to assess the potential for small debris induced failure for all disposal-critical components. Additional shielding might then be necessary in order to meet the acceptable risk requirement for the overall mission. Traditionally this requirement had been met with little or no additional shielding. Since the introduction of a high density debris population in ORDEM 3.0, some missions, especially those in higher portions of Low Earth Orbit, have needed additional MMOD-specific shielding in order for the mission to meet the requirement. This is a costly design effort when performed late in the project life cycle, which adds unexpected mass to the spacecraft components during the integration phase, and could disrupt thermal management. A proposal is discussed to develop a more cost-effective approach to MMOD-shielding, which can be employed earlier in the hardware design phase. The development and adoption of standardized shielding assemblies allows early tailoring of the shielding around a component, so that the mass is accounted for, as well as the small particle penetration risk, at a point in the design phase when the cost and schedule impact are more manageable. A set of several assemblies can be developed with a range of protection thresholds, in order to control mass where less shielding is needed. Such shielding assemblies would be developed in collaboration with blanket assembly specialists and thermal control engineers to ensure manufacturability and thermal performance challenges are known and acceptable. One clear benefit of such an approach is that hypervelocity testing can be performed on each of the standard shield assemblies to refine and confirm their performance prior to use.The challenges inherent in designing supplemental MMOD shielding will be discussed, including variations in the orbital debris environment and performance prediction. The benefits of a standardized shielding approach and example applications will also be presented.

Hull, Scott M.↗
NASA NTRS2004

Progress Toward Electrostatic Radiation Shielding of Interplanetary Spacecraft: Strategies, Concepts and Technical Challenges of Human Exploration Beyond Low Earth Orbit

The radiation problem is a serious obstacle to solar system exploration. Electrostatic shielding was previously dismissed as unworkable. This was based on the false assumption that radial symmetry is needed to provide isotropic protection. KSC recently demonstrated the feasibility of asymmetric, multipole electrostatic shielding. Combined with passive shielding it might solve the radiation problem

Metzger, Philip T.↗