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For interplanetary spacecraft that will travel to destinations where future life detection experiments may be conducted or samples are to be returned to earth, we should archive and preserve relevant samples from the spacecraft and cleanrooms for evaluation at a future date.
Prolonged microgravity exposure disrupts bone, muscle, and cardiovascular homeostasis, sensory-motor coordination, immune function, and behavioral performance. Bone loss, in particular, remains a serious impediment to the success of exploration-class missions by increasing the risks of bone fracture and renal stone formation for crew members. Current countermeasures, consisting primarily of resistive and aerobic exercise, have not yet proven fully successful for preventing bone loss during long-duration spaceflight. While other bone-specific countermeasures, such as pharmacological therapy and dietary modifications, are under consideration, countermeasure approaches that simultaneously address multiple physiologic systems may be more desirable for exploration-class missions, particularly if they can provide effective protection at reduced mission resource requirements (up-mass, power, crew time, etc). The most robust of the multi-system approaches under consideration, artificial gravity (AG), could prevent all of the microgravity-related physiological changes from occurring. The potential methods for realizing an artificial gravity countermeasure are reviewed, as well as selected animal and human studies evaluating the effects of artificial gravity on bone function. Future plans for the study of the multi-system effects of artificial gravity include a joint, cooperative international effort that will systematically seek an optimal prescription for intermittent AG to preserve bone, muscle, and cardiovascular function in human subjects deconditioned by 6 degree head-down-tilt-bed rest. It is concluded that AG has great promise as a multi-system countermeasure, but that further research is required to determine the appropriate parameters for implementation of such a countermeasure for exploration-class missions.
A method and apparatus for controlling an earthworking implement on an earthworking machine to preserve a crown on the surface of a road, including determining the position of the crown on the road surface, choosing a sloped grade on one side of the crown, positioning the earthworking implement on the sloped grade so that a first end of the earthworking implement is on the road surface. The processor determines a desired position of a second end of the earthworking implement so that the second end overlaps the crown and the earthworking implement does not cut the crown.
Upcoming Mars missions (e.g., Mars Science Laboratory, ExoMars, Astrobiology Field Laboratory, and Mars Sample Return) will search for evidence of extant and fossil microbial habitats and the potential for future habitation. Understanding the distribution and composition of reduced carbon (or organic carbon) is critical for unraveling the Martian carbon cycle, potential for life, and possible biosignature record. Reduced carbon may be produced from biological, geochemical, or interstellar processes; however, evidence for reduced carbon on Mars is lacking with the exception of parts per billion of atmospheric methane. In contrast, abundant atmospheric carbon dioxide may reflect surface oxidation of reduced carbon and accumulation over geological timescales. This suggests that there is an undetected or lost pool of reduced carbon - a pool that may host molecular biosignatures, a characteristic of extant or extinct habitability. In this presentation, we will evaluate factors influencing the preservation potential for organic molecules in rocks on Earth and Martian. We,draw examples from organic molecules in sulfates, basalts, and ancient shales from Mars-analog settings to show how the distribution of organics and their structural patterns will aid Mars habitability studies.
Much recent research points to the shrinkage of the Earth's small glaciers, however, few studies have been performed to quantify the amount of change over time. We measured glacier-extent changes in two national parks in southeastern Alaska. There are hundreds of glaciers in Kenai Fjords National Park (KEFJ) and Katmai National Park and Preserve (KATM) covering over 2373 sq km of parkland. There are two primary areas of glaciation in KEFJ - the Harding Icefield and the Grewingk-Yalik Glacier Complex, and three primary areas of glaciation in KATM - the Mt. Douglas area, the Kukak Volcano to Mt. Katmai area and the Mt. Martin area. We performed glacier mapping using satellite imagery, from the 1970s, 1980s, and from 2000. Results of the analysis show that there has been a reduction in the amount of glacier ice cover in the two parks over the study period, of approximately 22 sq km of ice, approximately - 1.6% from 1986 to 2000 (for KEFJ), and of approximately 76 sq km of glacier ice, or about -7.7% from 1986187 to 2000 (for KATM). In the future, measurements of surface elevation changes of these ice masses should be acquired; together with our extent-change measurements, the volume change of the ice masses can then be determined to estimate their contribution to sea-level rise. The work is a continuation of work done in KEFJ, but in KATM, our measurements represent the first comprehensive study of the glaciers in this remote, little-studied area.
Green engineering and operations are essential to preserving the near-Earth space environment for future generations. The U.S. and the international aerospace community have been proactive in addressing the threat of the increasing orbital debris population and the risks to people and property from reentering debris. NASA has led this activity first by devoting resources to thoroughly understand the technical issues and then by developing effective and acceptable policies and guidelines. NASA also worked closely with the international community to ensure that the US aerospace industry was not placed at an economic disadvantage. In the long term, the removal of large orbital debris will be essential to the sustainability of space operations.
This document reviews the work of the author in NASA's Motivating Undergraduates in Science and Technology (MUST) internship. The intern worked on the Space Shuttles hydraulic systems (i.e., Auxiliary Power Units (APU's) and Hydraulic Pump Units (HPU's)), and website preservation of the hydraulic technology captured in websites relating to the coming.the Space Shuttle Retirement. Several figures and pictures show an overview of the orbiter's hydraulic systems
This slide presentation reviews the use of microwave technology for treating Atherosclerosis while preserving the endothelium. The system uses catheter antennas as part of the system that is intended to treat atherosclerosis. The concept is to use a microwave catheter for heating the atherosclerotic lesions, and reduce constriction in the artery.
The importance of ensuring preservation and useful access to the unique science potential of past, present and future NASA solar and space physics (i.e. heliophysics) data has been recognized since the inception of NASA but remains challenging. In this talk, I will briefly review the history of this topic and and then discuss the present NASA model for heliophysics science data management, including key current resources for finding and using data projects like the Space Physics Data Facility. I will highlight expected future directions, building on working elements of the present program and exploiting new technology, to further improve the data environment, address existing issues and anticipate emerging challenges.
Applications in superconductivity have become widespread, enabled by advancements in cryogenic engineering. In this paper, the history of cryogenic refrigeration, its delivery, its preservation and the important scientific and engineering advancements in these areas in the last 100 years will be reviewed, beginning with small laboratory dewars to very large scale systems. The key technological advancements in these areas that enabled the development of superconducting applications at temperatures from 4 to 77 K are identified. Included are advancements in the components used up to the present state-of-the-art in refrigeration systems design. Viewpoints as both an equipment supplier and the end-user with regard to the equipment design and operations will be presented. Some of the present and future challenges in these areas will be outlined. Most of the materials in this paper are a collection of the historical materials applicable to these areas of interest.
A solution has been formulated to preserve deoxyribonucleic acid (DNA) and ribonucleic acid (RNA) in specimens of blood, saliva, and other bodily fluids. Specimens of this type are collected for diagnostic molecular pathology, which is becoming the method of choice for diagnosis of many diseases. The solution makes it possible to store such specimens at room temperature, without risk of decomposition, for subsequent analysis in a laboratory that could be remote from the sampling location. Thus, the solution could be a means to bring the benefits of diagnostic molecular pathology to geographic regions where refrigeration equipment and diagnostic laboratories are not available. The table lists the ingredients of the solution. The functions of the ingredients are the following: EDTA chelates divalent cations that are necessary cofactors for nuclease activity. In so doing, it functionally removes these cations and thereby retards the action of nucleases. EDTA also stabilizes the DNA helix. Tris serves as a buffering agent, which is needed because minor contaminants in an unbuffered solution can exert pronounced effects on pH and thereby cause spontaneous degradation of DNA. SDS is an ionic detergent that inhibits ribonuclease activity. SDS has been used in some lysis buffers and as a storage buffer for RNA after purification. The use of the solution is straightforward. For example, a sample of saliva is collected by placing a cotton roll around in the subject's mouth until it becomes saturated, then the cotton is placed in a collection tube. Next, 1.5 mL of the solution are injected directly into the cotton and the tube is capped for storage at room temperature. The effectiveness of the solution has been demonstrated in tests on specimens of saliva containing herpes simplex virus. In the tests, the viral DNA, as amplified by polymerase chain reaction, was detected even after storage for 120 days.
There are hundreds of glaciers in Kenai Fjords National Park (KEFJ) and Katmai National Park and Preserve (KATM) covering over 2276 sq km of park land (circa 2000). There are two primary glacierized areas in KEFJ -- the Harding Icefield and the Grewingk-Yalik Glacier Complex, and three primary glacierized areas in KATM - the Mt. Douglas area, the Kukak Volcano to Mt. Katmai area and the Mt. Martin area. Most glaciers in these parks terminate on land, though a few terminate in lakes. Only KEFJ has tidewater glaciers, which terminate in the ocean. Glacier mapping and analysis of the change in glacier extent has been accomplished on a decadal scale using satellite imagery, primarily Landsat data from the 1970s, 1980s, and from 2000. Landsat Multispectral Scanner (MSS), Thematic Mapper (TM) and Enhanced Thematic Mapper Plus (ETM+) imagery was used to map glacier extent on a park-wide basis. Classification of glacier ice using image processing software, along with extensive manual editing, was employed to create Geographic Information System (GIS) outlines of the glacier extent for each park. Many glaciers that originate in KEFJ but terminate outside the park boundaries were also mapped. Results of the analysis show that there has been a reduction in the amount of glacier ice cover in the two parks over the study period. Our measurements show a reduction of approximately 21 sq km, or -1.5% (from 1986 to 2000), and 76 sq km, or -7.7% (from 1986/87 to 2000), in KEFJ and KATM, respectively. This work represents the first comprehensive study of glaciers of KATM. Issues that complicate the mapping of glacier extent include: debris-cover (moraine and volcanic ash), shadows, clouds, fresh snow, lingering snow from the previous season, and differences in spatial resolution between the MSS and TM or ETM+ sensors. Similar glacier mapping efforts in western Canada estimate mapping errors of 3-4%. Measurements were also collected from a suite of glaciers in KEFJ and KATM detailing terminus positions and rates of recession using datasets including the 15-minute USGS quadrangle maps (1950/1951), Landsat imagery (1986/1987, 2000, 2006) and 2005 Ikonos imagery (KEFJ only).
Weightlessness causes a cephalad fluid shift and reduction in mechanical stimulation, adversely affecting both cortical and trabecular bone tissue in astronauts. In rodent models of weightlessness, the onset of bone loss correlates with reduced skeletal perfusion, reduced and rarified vasculature and lessened vasodilation, which resembles blood-bone symbiotic events that can occur with fracture repair and aging. These are especially serious risks for long term, exploration class missions when astronauts will face the challenge of increased exposure to space radiation and abrupt transitions between different gravity environments upon arrival and return. Previously, we found using the mouse hindlimb unloading model and exposure to heavy ion radiation, both disuse and irradiation cause an acute bone loss that was associated with a reduced capacity to produce bone-forming osteoblasts from the bone marrow. Together, these findings led us to hypothesize that exposure to space radiation exacerbates weightlessness-induced bone loss and impairs recovery upon return, and that treatment with anti-oxidants may mitigate these effects. The specific aims of this recently awarded grant are to: AIM 1 Determine the functional and structural consequences of prolonged weightlessness and space radiation (simulated spaceflight) for bone and skeletal vasculature in the context of bone cell function and oxidative stress. AIM 2 Determine the extent to which an anti-oxidant protects against weightlessness and space radiation-induced bone loss and vascular dysfunction. AIM 3 Determine how space radiation influences later skeletal and vasculature recovery from prolonged weightlessness and the potential of anti-oxidants to preserve adaptive remodeling.
Saliva is an important body fluid for diagnostic purposes. Glycoproteins, glucose, steroids, DNA, and other molecules of diagnostic value are found in saliva. It is easier to collect as compared to blood or urine. Unfortunately, saliva also contains large numbers of bacteria that can release enzymes, which can degrade proteins and nucleic acids. These degradative enzymes destroy or reduce saliva s diagnostic value. This innovation describes the formulation of a chemical preservative that prevents microbial growth and inactivates the degradative enzymes. This extends the time that saliva can be stored or transported without losing its diagnostic value. Multiple samples of saliva can be collected if needed without causing discomfort to the subject and it does not require any special facilities to handle after it is collected.
The Apollo 11 mission left on the Moon a silicon disc inscribed with microscopic recreations of messages from 73 countries. NanoArk Corporation of Fairport, New York, built on that NASA technology to develop a fire and water resistant archiving innovation that provides cost savings and security in preserving documents. Since its launch, NanoArk has grown from 2 to 10 employees.
John B. Schutt, a chemist at Goddard Space Flight Center, created a coating for spacecraft that could resist corrosion and withstand high heat. After retiring from NASA, Schutt used his expertise to create new formulations for Daytona Beach, Florida-based Adsil Corporation, which now manufactures a family of coatings to preserve various surfaces. Adsil has created 150 jobs due to the products.
There are hundreds of glaciers in Kenai Fjords National Park (KEFJ) and Katmai National Park and Preserve (KATM) covering over 2,276 sq km of park land (ca. 2000). There are two primary glacierized areas in KEFJ (the Harding Icefield and the Grewingk-Yalik Glacier Complex) and three primary glacierized areas in KATM (the Mt. Douglas area, the Kukak Volcano to Mt. Katmai area, and the Mt. Martin area). Most glaciers in these parks terminate on land, though a few terminate in lakes. Only KEFJ has tidewater glaciers, which terminate in the ocean. Glacier mapping and analysis of the change in glacier extent has been accomplished on a decadal scale using satellite imagery, primarily Landsat data from the 1970s, 1980s, and from2000. Landsat Multispectral Scanner (MSS),Thematic Mapper (TM), and Enhanced Thematic Mapper Plus (ETM) imagery was used to map glacier extent on a park-wide basis. Classification of glacier ice using image-processing software, along with extensive manual editing, was employed to create Geographic Information System (GIS)outlines of the glacier extent for each park. Many glaciers that originate in KEFJ but terminate outside the park boundaries were also mapped. Results of the analysis show that there has been a reduction in the amount of glacier ice cover in the two parks over the study period. Our measurements show a reduction of approximately 21 sq km, or 1.5(from 1986 to 2000), and 76 sq km, or 7.7 (from19861987 to 2000), in KEFJ and KATM, respectively. This work represents the first comprehensive study of glaciers of KATM. Issues that complicate the mapping of glacier extent include debris cover(moraine and volcanic ash), shadows, clouds, fresh snow, lingering snow from the previous season, and differences in spatial resolution between the MSS,TM, or ETM sensors. Similar glacier mapping efforts in western Canada estimate mapping errors of 34. Measurements were also collected from a suite of glaciers in KEFJ and KATM detailing terminus positions and rates of recession using datasets including 15 min USGS quadrangle maps(19501951), Landsat imagery (19861987, 2000,2006), and 2005 IKONOS imagery (KEFJ only).
A mesh objective crack band model was implemented within the generalized method of cells micromechanics theory. This model was linked to a macroscale finite element model to predict post-peak strain softening in composite materials. Although a mesh objective theory was implemented at the microscale, it does not preclude pathological mesh dependence at the macroscale. To ensure mesh objectivity at both scales, the energy density and the energy release rate must be preserved identically across the two scales. This requires a consistent characteristic length or localization limiter. The effects of scaling (or not scaling) the dimensions of the microscale repeating unit cell (RUC), according to the macroscale element size, in a multiscale analysis was investigated using two examples. Additionally, the ramifications of the macroscale element shape, compared to the RUC, was studied.