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At least 163 records · Page 9

Stochastic image reconstruction for a dual-particle imaging system

Stochastic image reconstruction has been applied to a dual-particle imaging system being designed for nuclear safeguards applications. The dual-particle imager (DPI) is a combined Compton-scatter and neutron-scatter camera capable of producing separate neutron and photon images. The stochastic origin ensembles (SOE) method was investigated as an imaging method for the DPI because only a minimal estimation of system response is required to produce images with quality that is comparable to common maximum-likelihood methods. Here, this work contains neutron and photon SOE image reconstructions for a 252Cf point source, two mixed-oxide (MOX) fuel canisters representing point sources, and the MOX fuel canisters representing a distributed source. Simulation of the DPI using MCNPX-PoliMi is validated by comparison of simulated and measured results. Because image quality is dependent on the number of counts and iterations used, the relationship between these quantities is investigated.

73 NUCLEAR PHYSICS AND RADIATION PHYSICS↗

Integrative Quantitative-Phase and Airy Light-Sheet Imaging

Light-sheet microscopy enables considerable speed and phototoxicity gains, while quantitative-phase imaging confers label-free organelle recognition and metabolic information that are inaccessible by conventional methods. We report the fusion of these two modalities onto a standard inverted microscope that retains compatibility with microfluidics. We describe the utilization of an accelerating Airy-beam light-sheet yielding identical imaging areas with interferometry, and an application in unmasking the effects of cellular noise on metabolic compartmentalization.

Biological sciences, Biological techniques, Micros↗

Simulating image coaddition with the Nancy Grace Roman Space Telescope – II. Analysis of the simulated images and implications for weak lensing

One challenge for applying current weak lensing analysis tools to the Nancy Grace Roman Space Telescope is that individual images will be undersampled. Our companion paper presented an initial application of Imcom – an algorithm that builds an optimal mapping from input to output pixels to reconstruct a fully sampled combined image – on the Roman image simulations. In this paper, we measure the output noise power spectra, identify the sources of the major features in the power spectra, and show that simple analytic models that ignore sampling effects underestimate the power spectra of the coadded noise images. We compute the moments of both idealized injected stars and fully simulated stars in the coadded images, and their one- and two-point statistics. We show that the idealized injected stars have root-mean-square ellipticity errors (1–6) × 10 -4 per component depending on the band; the correlation functions are ≥2 orders of magnitude below requirements, indicating that the image combination step itself is using a small fraction of the overall Roman second moment error budget, although the fourth moments are larger and warrant further investigation. The stars in the simulated sky images, which include blending and chromaticity effects, have correlation functions near the requirement level (and below the requirement level in a wide-band image constructed by stacking all four filters). We evaluate the noise-induced biases in the ellipticities of injected stars, and explain the resulting trends with an analytical model. We conclude by enumerating the next steps in developing an image coaddition pipeline for Roman.

79 ASTRONOMY AND ASTROPHYSICS↗

SU-E-J-13: Six Degree of Freedom Image Fusion Accuracy for Cranial Target Localization On the Varian Edge Stereotactic Radiosurgery System: Comparison Between 2D/3D and KV CBCT Image Registration

Purpose: To determine the 6 degree of freedom systematic deviations between 2D/3D and CBCT image registration with various imaging setups and fusion algorithms on the Varian Edge Linac. Methods: An anthropomorphic head phantom with radio opaque targets embedded was scanned with CT slice thicknesses of 0.8, 1, 2, and 3mm. The 6 DOF systematic errors were assessed by comparing 2D/3D (kV/MV with CT) with 3D/3D (CBCT with CT) image registrations with different offset positions, similarity measures, image filters, and CBCT slice thicknesses (1 and 2 mm). The 2D/3D registration accuracy of 51 fractions for 26 cranial SRS patients was also evaluated by analyzing 2D/3D pre-treatment verification taken after 3D/3D image registrations. Results: The systematic deviations of 2D/3D image registration using kV- kV, MV-kV and MV-MV image pairs were within ±0.3mm and ±0.3° for translations and rotations with 95% confidence interval (CI) for a reference CT with 0.8 mm slice thickness. No significant difference (P>0.05) on target localization was observed between 0.8mm, 1mm, and 2mm CT slice thicknesses with CBCT slice thicknesses of 1mm and 2mm. With 3mm CT slice thickness, both 2D/3D and 3D/3D registrations performed less accurately in longitudinal direction than thinner CT slice thickness (0.60±0.12mm and 0.63±0.07mm off, respectively). Using content filter and using similarity measure of pattern intensity instead of mutual information, improved the 2D/3D registration accuracy significantly (P=0.02 and P=0.01, respectively). For the patient study, means and standard deviations of residual errors were 0.09±0.32mm, −0.22±0.51mm and −0.07±0.32mm in VRT, LNG and LAT directions, respectively, and 0.12°±0.46°, −0.12°±0.39° and 0.06°±0.28° in RTN, PITCH, and ROLL directions, respectively. 95% CI of translational and rotational deviations were comparable to those in phantom study. Conclusion: 2D/3D image registration provided on the Varian Edge radiosurgery, 6 DOF-based system provides accurate target positioning for frameless image-guided cranial stereotactic radiosurgery.

60 APPLIED LIFE SCIENCES↗

WE-G-207-06: 3D Fluoroscopic Image Generation From Patient-Specific 4DCBCT-Based Motion Models Derived From Physical Phantom and Clinical Patient Images

Purpose: Respiratory-correlated cone-beam CT (4DCBCT) images acquired immediately prior to treatment have the potential to represent patient motion patterns and anatomy during treatment, including both intra- and inter-fractional changes. We develop a method to generate patient-specific motion models based on 4DCBCT images acquired with existing clinical equipment and used to generate time varying volumetric images (3D fluoroscopic images) representing motion during treatment delivery. Methods: Motion models are derived by deformably registering each 4DCBCT phase to a reference phase, and performing principal component analysis (PCA) on the resulting displacement vector fields. 3D fluoroscopic images are estimated by optimizing the resulting PCA coefficients iteratively through comparison of the cone-beam projections simulating kV treatment imaging and digitally reconstructed radiographs generated from the motion model. Patient and physical phantom datasets are used to evaluate the method in terms of tumor localization error compared to manually defined ground truth positions. Results: 4DCBCT-based motion models were derived and used to generate 3D fluoroscopic images at treatment time. For the patient datasets, the average tumor localization error and the 95th percentile were 1.57 and 3.13 respectively in subsets of four patient datasets. For the physical phantom datasets, the average tumor localization error and the 95th percentile were 1.14 and 2.78 respectively in two datasets. 4DCBCT motion models are shown to perform well in the context of generating 3D fluoroscopic images due to their ability to reproduce anatomical changes at treatment time. Conclusion: This study showed the feasibility of deriving 4DCBCT-based motion models and using them to generate 3D fluoroscopic images at treatment time in real clinical settings. 4DCBCT-based motion models were found to account for the 3D non-rigid motion of the patient anatomy during treatment and have the potential to localize tumor and other patient anatomical structures at treatment time even when inter-fractional changes occur. This project was supported, in part, through a Master Research Agreement with Varian Medical Systems, Inc., Palo Alto, CA. The project was also supported, in part, by Award Number R21CA156068 from the National Cancer Institute.

60 APPLIED LIFE SCIENCES↗

TH-AB-202-06: BEST IN PHYSICS (JOINT IMAGING-THERAPY): A Real-Time Tumor Tracking Using Novel Scatter Imaging Modality During Lung SBRT

Purpose: Compared to traditional radiotherapy techniques, stereotactic body radiation therapy (SBRT) provides more favorable outcomes during the treatment of certain lung tumors. Despite advancements in image guidance, accurate target localization still remains a challenge. In this work, we expand our knowledge of a novel scatter imaging modality in order to develop a real-time tumor localization method using scattered photons from the patient during treatment. Methods: Images of the QUASAR™ Respiratory Motion Phantom were taken by irradiating it on a Varian TrueBeam accelerator. The scattered radiation was detected using a flat panel-based pinhole camera detection system. Two motion settings were investigated: static and dynamic. In the former, the lung tumor was manually shifted between imaging. In the latter, the lung tumor was set to move at a certain frequency and amplitude while the images were acquired continuously for one minute. The accuracy of tumor localization and the irradiation time required to distinguish the lung tumor were studied. Results: The comparison of measured and expected location of the lung tumor during static motion was shown to be under standard deviation (STD) of 0.064 with a mean STD of 0.031cm. The dynamic motion was taken at a rate of 1400 MU/min for one minute and the measured location of the lung tumor was then compared with the QUASAR phantom’s sinusoidal motion pattern and the agreement found to be at an average STD of 0.275cm. The location of the lung tumor was investigated using aggregate images consisting of 1 or 2 frames/image and the change was below STD of 0.30cm. The lung tumor also appeared to be blurrier in images consisting of two frames. Conclusion: Based on our preliminary results real-time image guidance using the scatter imaging modality to localize and track tumors during lung SBRT has the potential to become clinical reality.

60 APPLIED LIFE SCIENCES↗

Source shape estimation for neutron imaging systems using convolutional neural networks

Neutron imaging systems are important diagnostic tools for characterizing the physics of inertial confinement fusion reactions at the National Ignition Facility (NIF). In particular, neutron images give diagnostic information on the size, symmetry, and shape of the fusion hot spot and surrounding cold fuel. Images are formed via collection of neutron flux from the source using a system of aperture arrays and scintillator-based detectors. Currently, reconstruction of fusion source geometry from the collected neutron images is accomplished by solving a computationally intensive maximum likelihood estimation problem via expectation maximization. In contrast, it is often useful to have simple representations of the overall source geometry that can be computed quickly. In this work, we develop convolutional neural networks (CNNs) to reconstruct the outer contours of simple source geometries. We compare the performance of the CNN for penumbral and pinhole data and provide experimental demonstrations of our methods on both non-noisy and noisy data.

Machine learning, neutron imaging, source reconstr↗

SU-E-I-84: Accuracy Comparison of Multi-Modality Image-Based Volumes of Rodent Solid Tumors Using In-Air Micro-CT Image Volume

Purpose: Tumor volume is considered as a better predictor for therapy response monitoring and tumor staging over Response Evaluation Criteria In Solid Tumors (RECIST) or World Health Organization (WHO) criteria. In this study, the accuracy of subcutaneous rodent tumor volumes using preclinical magnetic resonance imaging (MRI), micro-computed tomography (micro-CT) and ultrasound (US) equipment and with an external caliper was compared using in-air micro-CT image volume of excised tumors determined as reference tumor volume in our prior study. Methods: MR, US and micro-CT images of subcutaneous SCC4 head and neck tumor xenografts were acquired 4, 6, 9, 11 and 13 days after tumor cell inoculation. Before MR and US scans, caliper measurements were made. After tumors were excised, in-air micro-CT imaging and ex vivo caliper measurements were performed. Tumor volumes were calculated using formula V = (π/6)*a*b*c where a, b and c are the maximum diameters in three perpendicular dimensions determined by the three image modalities and caliper, and compared with reference tumor volume by linear regression analysis as well as Bland-Altman plots. A one-way Analysis of Variance (ANOVA) test was also performed to compare volumes among caliper measurements. Results: The correlation coefficients (R2) of the regression lines for tumor volumes measured by the three imaging modalities and caliper were 0.9939, 0.9669, 0.9806, 0.9274, 0.9619 and 0.9819 for MRI, US and micro-CT, caliperbeforeMRI, caliperbeforeUS and ex vivo caliper respectively. In Bland-Altman plots, the average of tumor volume difference from reference tumor volume (bias) was significant for caliper and micro- CT, but not for MRI and US. Comparison of caliper measurements showed a significant difference (p < 0.05). Conclusion: Using the in-air micro-CT image volume, tumor volume measured by MRI was the most accurate among the three imaging modalities. In vivo caliper volume measurements showed unreliability while ex vivo caliper measurements reduced errors.

60 APPLIED LIFE SCIENCES↗

Design and demonstration of a low‐field magnetic resonance imaging rhizotron for in‐field imaging of energy sorghum roots

Abstract Root phenotyping provides critical information to plant breeders for developing varieties with improved drought tolerance, greater root biomass, and greater nutrient use efficiency. Phenotyping roots in the natural environment is important for understanding the effect of the soil environment on root genotypic expressions. The goal of this work was to design and test a field‐scale mobile low‐field magnetic resonance imaging (LF‐MRI) Rhizotron that produces actionable root phenotyping data. We demonstrated this novel technology for root visualization and quantification using a LF‐MRI Rhizotron operating at 47 mT with two soil types. The LF‐MRI Rhizotron weights 453 kg, with a height of 90 cm, a diameter of 28 cm and an imaging field of view of 28 cm × 28 cm. The unit was operated in a Belk clay (Entic Hapluderts) and Weswood silt loam (Udifluventic Halustepts) generating 2‐D and 3‐D image data sets. The 2‐D image data had a collection time of 16.5 min per image at an image resolution of 2.2 mm per pixel. The 3‐D data had a collection time of 13 h per image with a 2.2 × 2.2 × 2.2 mm voxel resolution. Low‐field magnetic resonance imaging worked well for visualizing roots in moderate to high clay soils, demonstrating the potential for this technology; however, the broad application of this platform is hampered due to the prohibitively long scanning time to obtain 3‐D images. By increasing the field strength, and therefore the signal‐to‐noise ratio, faster scan times can enable a more useful system for root phenotyping.

Bagnall, G. Cody↗

Comparison of image noise and image quality between full-dose abdominal computed tomography scans reconstructed with weighted filtered back projection and half-dose scans reconstructed with improved sinogram-affirmed iterative reconstruction (SAFIRE*)

Purpose: To retrospectively compare the image noise, signal-to-noise ratio (SNR), and subjective image quality between CT images acquired with a dual-source, split-dose imaging protocol reconstructed at full and half doses with weighted filtered back projection (wFBP) and an improved sinogram-affirmed iterative reconstruction algorithm (SAFIRE*). Methods: Fifty-three consecutive patients underwent contrast-enhanced CT of the abdomen using a standardized dual-source, single energy CT protocol. Half-dose images were retrospectively generated using data from one detector only. Full-dose datasets were reconstructed with wFBP, while half-dose datasets were reconstructed with wFBP and SAFIRE* strengths 1–5. Region of interest analysis was performed to assess SNR and noise. Diagnostic acceptability, subjective noise, and spatial resolution were graded on a 10-point scale by two readers. Statistical analysis was carried out with repeated measures analysis of variance, Wilcoxon signed rank test, and Cohen’s κ test. Results: With the increasing strengths of SAFIRE*, a progressive reduction in noise and increase in SNR (p < 0.01) was observed. There was a statistically significant decrease in objective noise and increase in SNR in half-dose SAFIRE* strength 4 and 5 reconstructions compared to full-dose reconstructions using wFBP (p < 0.01). Qualitative analysis revealed a progressive increase in diagnostic acceptability, decrease in subjective noise and increase in spatial resolution for half-dose images reconstructed with the increasing strengths of SAFIRE* (p < 0.01). Conclusions: Half-dose CT images reconstructed with SAFIRE* at strength 4 and 5 have superior image quality compared to full-dose images reconstructed with wFBP. SAFIRE* potentially allows dose reductions in the order of 50% over wFBP.

62 RADIOLOGY AND NUCLEAR MEDICINE↗

An image classification deep-learning algorithm for shrapnel detection from ultrasound images

Ultrasound imaging is essential for non-invasively diagnosing injuries where advanced diagnostics may not be possible. However, image interpretation remains a challenge as proper expertise may not be available. In response, artificial intelligence algorithms are being investigated to automate image analysis and diagnosis. Here, we highlight an image classification convolutional neural network for detecting shrapnel in ultrasound images. As an initial application, different shrapnel types and sizes were embedded first in a tissue mimicking phantom and then in swine thigh tissue. The algorithm architecture was optimized stepwise by minimizing validation loss and maximizing F1 score. The final algorithm design trained on tissue phantom image sets had an F1 score of 0.95 and an area under the ROC curve of 0.95. It maintained higher than a 90% accuracy for each of 8 shrapnel types. When trained only on swine image sets, the optimized algorithm format had even higher metrics: F1 and area under the ROC curve of 0.99. Overall, the algorithm developed resulted in strong classification accuracy for both the tissue phantom and animal tissue. This framework can be applied to other trauma relevant imaging applications such as internal bleeding to further simplify trauma medicine when resources and image interpretation are scarce.

59 BASIC BIOLOGICAL SCIENCES↗

Commissioning of a proton gantry equipped with dual x-ray imagers and a robotic patient positioner, and evaluation of the accuracy of single-beam image registration for this system

Purpose: To check the accuracy of a gantry equipped with dual x-ray imagers and a robotic patient positioner for proton radiotherapy, and to evaluate the accuracy and feasibility of single-beam registration using the robotic positioner. Methods: One of the proton treatment rooms at their institution was upgraded to include a robotic patient positioner (couch) with 6 degrees of freedom and dual orthogonal kilovoltage x-ray imaging panels. The wander of the proton beam central axis, the wander of the beamline, and the orthogonal image panel crosswires from the gantry isocenter were measured for different gantry angles. The couch movement accuracy and couch wander from the gantry isocenter were measured for couch loadings of 50–300 lb with couch rotations from 0° to ±90°. The combined accuracy of the gantry, couch, and imagers was checked using a custom-made 30 × 30 × 30 cm{sup 3} Styrofoam phantom with beekleys embedded in it. A treatment in this room can be set up and registered at a setup field location, then moved precisely to any other treatment location without requiring additional image registration. The accuracy of the single-beam registration strategy was checked for treatments containing multiple beams with different combinations of gantry angles, couch yaws, and beam locations. Results: The proton beam central axis wander from the gantry isocenter was within 0.5 mm with gantry rotations in both clockwise (CW) and counterclockwise (CCW) directions. The maximum wander of the beamline and orthogonal imager crosswire centers from the gantry isocenter were within 0.5 and 0.8 mm, respectively, with the gantry rotations in CW and CCW directions. Vertical and horizontal couch wanders from the gantry isocenter were within 0.4 and 1.3 mm, respectively, for couch yaw from 0° to ±90°. For a treatment with multiple beams with different gantry angles, couch yaws, and beam locations, the measured displacements of treatment beam locations from the one based on the initial setup beam registered at the gantry at 0°/180° and couch yaw at 0° were within 1.5 mm in three translations and 0.5° in three rotations for a 200 lb couch loading. Conclusions: Results demonstrate that the gantry equipped with a robotic patient positioner and dual imaging panels satisfies treatment requirements for proton radiotherapy. The combined accuracy of the gantry, couch, and imagers allows a patient to be registered at one setup position and then moved precisely to another treatment position by commanding the robotic patient positioner and delivering treatment without requiring additional image registration.

07 ISOTOPE AND RADIATION SOURCES↗

WE-EF-207-01: FEATURED PRESENTATION and BEST IN PHYSICS (IMAGING): Task-Driven Imaging for Cone-Beam CT in Interventional Guidance

Purpose: This work introduces a task-driven imaging framework that utilizes a patient-specific anatomical model, mathematical definition of the imaging task, and a model of the imaging system to prospectively design acquisition and reconstruction techniques that maximize task-based imaging performance. Utility of the framework is demonstrated in the joint optimization of tube current modulation and view-dependent reconstruction kernel in filtered-backprojection reconstruction and non-circular orbit design in model-based reconstruction. Methods: The system model is based on a cascaded systems analysis of cone-beam CT capable of predicting the spatially varying noise and resolution characteristics as a function of the anatomical model and a wide range of imaging parameters. Detectability index for a non-prewhitening observer model is used as the objective function in a task-driven optimization. The combination of tube current and reconstruction kernel modulation profiles were identified through an alternating optimization algorithm where tube current was updated analytically followed by a gradient-based optimization of reconstruction kernel. The non-circular orbit is first parameterized as a linear combination of bases functions and the coefficients were then optimized using an evolutionary algorithm. The task-driven strategy was compared with conventional acquisitions without modulation, using automatic exposure control, and in a circular orbit. Results: The task-driven strategy outperformed conventional techniques in all tasks investigated, improving the detectability of a spherical lesion detection task by an average of 50% in the interior of a pelvis phantom. The non-circular orbit design successfully mitigated photon starvation effects arising from a dense embolization coil in a head phantom, improving the conspicuity of an intracranial hemorrhage proximal to the coil. Conclusion: The task-driven imaging framework leverages a knowledge of the imaging task within a patient-specific anatomical model to optimize image acquisition and reconstruction techniques, thereby improving imaging performance beyond that achievable with conventional approaches. 2R01-CA-112163; R01-EB-017226; U01-EB-018758; Siemens Healthcare (Forcheim, Germany)

60 APPLIED LIFE SCIENCES↗

SNIa Cosmology Analysis Results from Simulated LSST Images: From Difference Imaging to Constraints on Dark Energy

Abstract The Vera Rubin Observatory Legacy Survey of Space and Time (LSST) is expected to process ∼10 6 transient detections per night. For precision measurements of cosmological parameters and rates, it is critical to understand the detection efficiency, magnitude limits, artifact contamination levels, and biases in the selection and photometry. Here we rigorously test the LSST Difference Image Analysis (DIA) pipeline using simulated images from the Rubin Observatory LSST Dark Energy Science Collaboration Data Challenge (DC2) simulation for the Wide-Fast-Deep survey area. DC2 is the first large-scale (300 deg 2 ) image simulation of a transient survey that includes realistic cadence, variable observing conditions, and CCD image artifacts. We analyze ∼15 deg 2 of DC2 over a 5 yr time span in which artificial point sources from Type Ia supernova (SNIa) light curves have been overlaid onto the images. The magnitude limits per filter are u = 23.66 mag, g = 24.69 mag, r = 24.06 mag, i = 23.45 mag, z = 22.54 mag, and y = 21.62 mag. The artifact contamination levels are ∼90% of all detections, corresponding to ∼1000 artifacts deg –2 in g band, and falling to 300 deg –2 in y band. The photometry has biases <1% for magnitudes 19.5 < m < 23. Our DIA performance on simulated images is similar to that of the Dark Energy Survey difference-imaging pipeline on real images. We also characterize DC2 image properties to produce catalog-level simulations needed for distance bias corrections. We find good agreement between DC2 data and simulations for distributions of signal-to-noise ratio, redshift, and fitted light-curve properties. Applying a realistic SNIa cosmology analysis for redshifts z < 1, we recover the input cosmology parameters to within statistical uncertainties.

79 ASTRONOMY AND ASTROPHYSICS↗

Image understanding and interpretation in microwave diversity imaging

The authors investigate microwave imaging of metallic objects using a diversity method and interpret and predict the reconstructed image from an approach based on analysis of the scattering mechanism and a back-projection algorithm used in image retrieval. The connection between the various scattering mechanisms and the reconstructed images is discussed, what the images represent is interpreted, and a prediction is made as to what the image will look like over given spectral and angular windows. A brief description is given of the microwave diversity imaging system and the formulation of the microwave diversity imaging based on the physical optics approximation. The scattering mechanism of a complex shaped metallic object is then briefly reviewed and an alternate approach to interpreting the reconstructed image based on the understanding of the scattering mechanism and the reconstruction algorithm is given. Several numerical and experimental examples are included to support this interpretation approach.

Li, Hsueh-Jyh↗

An adaptive technique to maximize lossless image data compression of satellite images

Data compression will pay an increasingly important role in the storage and transmission of image data within NASA science programs as the Earth Observing System comes into operation. It is important that the science data be preserved at the fidelity the instrument and the satellite communication systems were designed to produce. Lossless compression must therefore be applied, at least, to archive the processed instrument data. In this paper, we present an analysis of the performance of lossless compression techniques and develop an adaptive approach which applied image remapping, feature-based image segmentation to determine regions of similar entropy and high-order arithmetic coding to obtain significant improvements over the use of conventional compression techniques alone. Image remapping is used to transform the original image into a lower entropy state. Several techniques were tested on satellite images including differential pulse code modulation, bi-linear interpolation, and block-based linear predictive coding. The results of these experiments are discussed and trade-offs between computation requirements and entropy reductions are used to identify the optimum approach for a variety of satellite images. Further entropy reduction can be achieved by segmenting the image based on local entropy properties then applying a coding technique which maximizes compression for the region. Experimental results are presented showing the effect of different coding techniques for regions of different entropy. A rule-base is developed through which the technique giving the best compression is selected. The paper concludes that maximum compression can be achieved cost effectively and at acceptable performance rates with a combination of techniques which are selected based on image contextual information.

Stewart, Robert J.↗