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At least 163 records · Page 9

Loss of 'complexity' and aging. Potential applications of fractals and chaos theory to senescence

The concept of "complexity," derived from the field of nonlinear dynamics, can be adapted to measure the output of physiologic processes that generate highly variable fluctuations resembling "chaos." We review data suggesting that physiologic aging is associated with a generalized loss of such complexity in the dynamics of healthy organ system function and hypothesize that such loss of complexity leads to an impaired ability to adapt to physiologic stress. This hypothesis is supported by observations showing an age-related loss of complex variability in multiple physiologic processes including cardiovascular control, pulsatile hormone release, and electroencephalographic potentials. If further research supports this hypothesis, measures of complexity based on chaos theory and the related geometric concept of fractals may provide new ways to monitor senescence and test the efficacy of specific interventions to modify the age-related decline in adaptive capacity.

Non-NASA Center↗

SU-E-J-230: Evaluation of ViewRay 0.35 T MRI Normal Structure Segmentation

Purpose: In order to take advantage of the high resolution soft tissue imaging available in MR images, we investigated 3D images obtained with the low field 0.35 T MR in ViewRay to serve as an alternative to CT scans for radiotherapy treatment planning. In these images, normal and target structure delineation can be visualized. Assessment is based upon comparison with the CT images and the ability to produce comparable contours. Methods: Routine radiation oncology CT scans were acquired on five patients. Contours of brain, brainstem, esophagus, heart, lungs, spinal cord, and the external body were drawn. The same five patients were then scanned on the ViewRay TrueFISP-based imaging pulse sequence. The same organs were selected on the MR images and compared to those from the CT scan. Physical volume and the Dice Similarity Coefficient (DSC) were used to assess the contours from the two systems. Image quality stability was quantitatively ensured throughout the study following the recommendations of the ACR MR accreditation procedure. Results: The highest DSC of 0.985, 0.863, and 0.843 were observed for brain, lungs, and heart respectively. On the other hand, the brainstem, spinal cord, and esophagus had the lowest DSC. Volume agreement was most satisfied for the heart (within 5%) and the brain (within 2%). Contour volume for the brainstem and lung (a widely dynamic organ) varied the most (27% and 19%). Conclusion: The DSC and volume measurements suggest that the results obtained from ViewRay images are quantitatively consistent and comparable to those obtained from CT scans for the brain, heart, and lungs. MR images from ViewRay are well-suited for treatment planning and for adaptive MRI-guided radiotherapy. The physical data from 0.35 T MR imaging is consistent with our geometrical understanding of normal structures.

60 APPLIED LIFE SCIENCES↗

Direct simulation Monte Carlo prediction of on-orbit contaminant deposit levels for HALOE

A three-dimensional version of the direct simulation Monte Carlo method is adapted to assess the contamination environment surrounding a highly detailed model of the Upper Atmosphere Research Satellite. Emphasis is placed on simulating a realistic, worst-case set of flow field and surface conditions and geometric orientations for the satellite in order to estimate an upper limit for the cumulative level of volatile organic molecular deposits at the aperture of the Halogen Occultation Experiment. A detailed description of the adaptation of this solution method to the study of the satellite's environment is also presented. Results pertaining to the satellite's environment are presented regarding contaminant cloud structure, cloud composition, and statistics of simulated molecules impinging on the target surface, along with data related to code performance. Using procedures developed in standard contamination analyses, along with many worst-case assumptions, the cumulative upper-limit level of volatile organic deposits on HALOE's aperture over the instrument's 35-month nominal data collection period is estimated at about 13,350 A.

Woronowicz, Michael S.↗

An Adaptively-Refined, Cartesian, Cell-Based Scheme for the Euler and Navier-Stokes Equations

A Cartesian, cell-based scheme for solving the Euler and Navier-Stokes equations in two dimensions is developed and tested. Grids about geometrically complicated bodies are generated automatically, by recursive subdivision of a single Cartesian cell encompassing the entire flow domain. Where the resulting cells intersect bodies, polygonal 'cut' cells are created. The geometry of the cut cells is computed using polygon-clipping algorithms. The grid is stored in a binary-tree data structure which provides a natural means of obtaining cell-to-cell connectivity and of carrying out solution-adaptive refinement. The Euler and Navier-Stokes equations are solved on the resulting grids using a finite-volume formulation. The convective terms are upwinded, with a limited linear reconstruction of the primitive variables used to provide input states to an approximate Riemann solver for computing the fluxes between neighboring cells. A multi-stage time-stepping scheme is used to reach a steady-state solution. Validation of the Euler solver with benchmark numerical and exact solutions is presented. An assessment of the accuracy of the approach is made by uniform and adaptive grid refinements for a steady, transonic, exact solution to the Euler equations. The error of the approach is directly compared to a structured solver formulation. A non smooth flow is also assessed for grid convergence, comparing uniform and adaptively refined results. Several formulations of the viscous terms are assessed analytically, both for accuracy and positivity. The two best formulations are used to compute adaptively refined solutions of the Navier-Stokes equations. These solutions are compared to each other, to experimental results and/or theory for a series of low and moderate Reynolds numbers flow fields. The most suitable viscous discretization is demonstrated for geometrically-complicated internal flows. For flows at high Reynolds numbers, both an altered grid-generation procedure and a different formulation of the viscous terms are shown to be necessary. A hybrid Cartesian/body-fitted grid generation approach is demonstrated. In addition, a grid-generation procedure based on body-aligned cell cutting coupled with a viscous stensil-construction procedure based on quadratic programming is presented.

Coirier, William John↗

Surface Remeshing with Robust High-Order Reconstruction

Remeshing is an important problem in variety of applications, such as finite element methods and geometry processing. Surface remeshing poses some unique challenges, as it must deliver not only good mesh quality but also good geometric accuracy. For applications such as finite elements with high-order elements (quadratic or cubic elements), the geometry must be preserved to high-order (third-order or higher) accuracy, since low-order accuracy may undermine the convergence of numerical computations. The problem is particularly challenging if the CAD model is not available for the underlying geometry, and is even more so if the surface meshes contain some inverted elements. We describe remeshing strategies that can simultaneously produce high-quality triangular meshes, untangling mildly folded triangles and preserve the geometry to high-order of accuracy. Our approach extends our earlier works on high-order surface reconstruction and mesh optimization by enhancing its robustness with a geometric limiter for under-resolved geometries. We also integrate high-order surface reconstruction with surface mesh adaptation techniques, which alter the number of triangles and nodes. We demonstrate the utilization of our method to meshes for high-order finite elements, biomedical image-based surface meshes, and complex interface meshes in fluid simulations.

Ray, Navamita↗

Time domain simulation of the response of geometrically nonlinear panels subjected to random loading

The response of composite panels subjected to random pressure loads large enough to cause geometrically nonlinear responses is studied. A time domain simulation is employed to solve the equations of motion. An adaptive time stepping algorithm is employed to minimize intermittent transients. A modified algorithm for the prediction of response spectral density is presented which predicts smooth spectral peaks for discrete time histories. Results are presented for a number of input pressure levels and damping coefficients. Response distributions are calculated and compared with the analytical solution of the Fokker-Planck equations. RMS response is reported as a function of input pressure level and damping coefficient. Spectral densities are calculated for a number of examples.

Moyer, E. Thomas, Jr.↗

Computational design of trimeric influenza-neutralizing proteins targeting the hemagglutinin receptor binding site

Many viral surface glycoproteins and cell surface receptors are homo-oligomers1, 2, 3, 4, and thus can potentially be targeted by geometrically matched homo-oligomers that engage all subunits simultaneously to attain high avidity and/or lock subunits together. The adaptive immune system cannot generally employ this strategy since the individual antibody binding sites are not arranged with appropriate geometry to simultaneously engage multiple sites in a single target homo-oligomer. We describe a general strategy for the computational design of homo-oligomeric protein assemblies with binding functionality precisely matched to homo-oligomeric target sites5, 6, 7, 8. In the first step, a small protein is designed that binds a single site on the target. In the second step, the designed protein is assembled into a homo-oligomer such that the designed binding sites are aligned with the target sites. We use this approach to design high-avidity trimeric proteins that bind influenza A hemagglutinin (HA) at its conserved receptor binding site. The designed trimers can both capture and detect HA in a paper-based diagnostic format, neutralizes influenza in cell culture, and completely protects mice when given as a single dose 24 h before or after challenge with influenza.

59 BASIC BIOLOGICAL SCIENCES↗

dynamical evolution of an ultra-relativistic fireball colliding with a freely expanding gas

We investigate the hydrodynamical evolution of an ultra-relativistic fireball colliding with a freely expanding gas. The hydrodynamical interaction of the fireball and the gas results in the formation of a geometrically thin shell. We study the dynamical evolution of the shell analytically and perform a numerical simulation equipped with adaptive mesh refinement to investigate the internal structure of the shell. The shocked gas can give rise to bright emission in the X-ray and gamma-ray energy range. We propose that the breakout emission from the forward shock and the photospheric emission from the reverse-shocked fireball contribute to early gamma-ray emission from gamma-ray bursts.

79 ASTRONOMY AND ASTROPHYSICS↗

WE-AB-BRA-07: Operating Room Quality Assurance (ORQA) for Spine Surgery Using Known-Component 3D-2D Image Registration

Purpose: Intraoperative x-ray radiography/fluoroscopy is commonly used to qualitatively assess delivery of surgical devices (e.g., spine pedicle screws) but can fail to reliably detect suboptimal placement (e.g., breach of adjacent critical structures). We present a method wherein prior knowledge of the patient and surgical components is leveraged to match preoperative CT and intraoperative radiographs for quantitative assessment of 3D pose. The method presents a new means of operating room quantitative quality assurance (ORQA) that could improve quality and safety, and reduce the frequency of revision surgeries. Methods: The algorithm (known-component registration, KC-Reg) uses patient-specific preoperative CT and parametrically defined surgical component models within a robust 3D-2D registration method to iteratively optimize gradient similarity using the covariance matrix adaptation evolution strategy. Advances from previous work address key challenges to clinical translation: i) absolving the need for offline geometric calibration of the C-arm; and ii) solving multiple component bodies simultaneously, thereby allowing QA in a single step (e.g., spinal construct with 4–20 screws), rather than sequential QA of each component. Performance was tested in a spine phantom with 10 pedicle screws, and first results from clinical studies are reported. Results: Phantom experiments demonstrated median target registration error (TRE) of (1.0±0.3) mm at the screw tip and (0.7°±0.4°) in angulation. The simultaneous multi-body registration approach improved TRE from the previous (sequential) method by 42%, reduced outliers, and fits into the natural workflow. Initial application of KC-Reg in clinical data shows TRE of (2.5±4.5) mm and (4.7°±0.5°). Conclusion: The KC-Reg algorithm offers a potentially valuable method for quantitative QA of the surgical product, using radiographic systems that are already within the surgical arsenal. For spine surgery, the method offers a near-real-time independent check on the quality of surgical product, facilitating immediate revision if necessary and potentially avoiding postoperative morbidity and/or revision surgery. Gerhard Kleinszig and Sebastian Vogt are employees of Siemens Healthcare.

60 APPLIED LIFE SCIENCES↗

An Hp-Adaptive Minimum Action Method Based on a Posteriori Error Estimate

In this work, we develop an hp-adaptive minimum action method (MAM). MAM plays an important role to minimize the Freidlin-Wentzell action functional, which is the central object of the Freidlin-Wentzell theory of large deviations for transitions induced by small random perturbations. Because of the demanding computation cost, especially in spatially extended systems, numerical efficiency is a critical issue for MAM. Difficulties come from discretizations of both time and space. One hurdle for the application of MAM to large scale systems is the global reparametrization in time direction, which is required by most versions of MAM. We recently introduced a new version of MAM in [25], called tMAM, where we used some simple heuristic criteria to demonstrate that tMAM can be effectively coupled with h-adaptivity. The target of this paper is to integrate hp-adaptivity into tMAM using a posterior error estimation techniques. More specifically, we use the arc length constraint given by geometric minimum action method (gMAM) to define an indicator of the effect of linear time scaling in tMAM, and the derivative recovery technique to construct an error indicator and a regularity indicator for hp-refinement. Numerical results are presented.

Wan, Xiaoliang↗

Image processing of HCMM-satellite thermal images for superposition with other satellite imagery and topographic and thematic maps

The southwestern part of Central Europe between Basal and Frankfurt was used in a study to determine the accuracy with which a regionally bounded HCMM scene could be rectified with respect to a preassigned coordinate system. The scale to which excerpts from HCMM data can be sensibly enlarged and the question of how large natural structures must be in order to be identified in a satellite thermal image with the given resolution were also examined. Relief and forest and population distribution maps and a land use map derived from LANDSAT data were digitalized and adapted to a common reference system and then combined in a single multichannel data system. The control points for geometrical rectification were determined using the coordinates of the reference system. The multichannel scene was evaluated in several different manners such as the correlation of surface temperature and relief, surface temperature and land use, or surface temperature and built up areas.

Gossmann, H.↗

Drought adaptation index (DAI) based on BLUP as a selection approach for drought-resilient switchgrass germplasm

This study introduces a Drought Adaptation Index (DAI), derived from Best Linear Unbiased Prediction (BLUP), as a method to assess drought resilience in switchgrass (Panicum virgatum L.). A panel of 404 genotypes was evaluated under drought-stressed (CV) and well-watered (UC) conditions over four consecutive years (2019–2022). BLUP-estimated biomass yields were used to calculate the DAI, which enabled classification of genotypes into four adaptation groups: very well-adapted, well-adapted, adapted, and unadapted. The DAI was compared with conventional drought tolerance indices, including the Stress Susceptibility Index (SSI), Stress Tolerance Index (STI), Geometric Mean Productivity (GMP), and Yield Stability Index (YSI). Correlation analyses demonstrated strong agreement between DAI and these indices, supporting its validity and consistency. Biplot analyses using the Genotype plus Genotype-by-Environment Interaction (GGE) and Additive Main Effects and Multiplicative Interaction (AMMI) models revealed significant genotype-by-environment interactions (GEI) and identified J222.A, J463.A, and J295.A. A as high-performing genotypes, with J222.A exhibiting greater yield stability across treatments and years. Additionally, DAI isoline curves provided a graphical representation of differential genotype performance under drought and control conditions. These visualizations aided in distinguishing genotypes with stable and superior biomass yield across contrasting environments. Overall, the BLUP-based DAI is a robust and practical selection tool that improves the accuracy of identifying drought-resilient, high-yielding switchgrass genotypes. Its integration into breeding programs offers a comprehensive framework for improving biomass productivity and stress adaptation under variable climatic conditions. The application of DAI supports the development of climate-resilient cultivars and contributes to sustainable bioenergy and forage production systems.

BLUP↗

Self-Avoiding Walks over Adaptive Triangular Grids

In this paper, we present a new approach to constructing a "self-avoiding" walk through a triangular mesh. Unlike the popular approach of visiting mesh elements using space-filling curves which is based on a geometric embedding, our approach is combinatorial in the sense that it uses the mesh connectivity only. We present an algorithm for constructing a self-avoiding walk which can be applied to any unstructured triangular mesh. The complexity of the algorithm is O(n x log(n)), where n is the number of triangles in the mesh. We show that for hierarchical adaptive meshes, the algorithm can be easily parallelized by taking advantage of the regularity of the refinement rules. The proposed approach should be very useful in the run-time partitioning and load balancing of adaptive unstructured grids.

Heber, Gerd↗

Electromagnetic guided couch and multileaf collimator tracking on a TrueBeam accelerator

Purpose: Couch and MLC tracking are two promising methods for real-time motion compensation during radiation therapy. So far, couch and MLC tracking experiments have mainly been performed by different research groups, and no direct comparison of couch and MLC tracking of volumetric modulated arc therapy (VMAT) plans has been published. The Varian TrueBeam 2.0 accelerator includes a prototype tracking system with selectable couch or MLC compensation. This study provides a direct comparison of the two tracking types with an otherwise identical setup. Methods: Several experiments were performed to characterize the geometric and dosimetric performance of electromagnetic guided couch and MLC tracking on a TrueBeam accelerator equipped with a Millennium MLC. The tracking system latency was determined without motion prediction as the time lag between sinusoidal target motion and the compensating motion of the couch or MLC as recorded by continuous MV portal imaging. The geometric and dosimetric tracking accuracies were measured in tracking experiments with motion phantoms that reproduced four prostate and four lung tumor trajectories. The geometric tracking error in beam’s eye view was determined as the distance between an embedded gold marker and a circular MLC aperture in continuous MV images. The dosimetric tracking error was quantified as the measured 2%/2 mm gamma failure rate of a low and a high modulation VMAT plan delivered with the eight motion trajectories using a static dose distribution as reference. Results: The MLC tracking latency was approximately 146 ms for all sinusoidal period lengths while the couch tracking latency increased from 187 to 246 ms with decreasing period length due to limitations in the couch acceleration. The mean root-mean-square geometric error was 0.80 mm (couch tracking), 0.52 mm (MLC tracking), and 2.75 mm (no tracking) parallel to the MLC leaves and 0.66 mm (couch), 1.14 mm (MLC), and 2.41 mm (no tracking) perpendicular to the leaves. The motion-induced gamma failure rate was in mean 0.1% (couch tracking), 8.1% (MLC tracking), and 30.4% (no tracking) for prostate motion and 2.9% (couch), 2.4% (MLC), and 41.2% (no tracking) for lung tumor motion. The residual tracking errors were mainly caused by inadequate adaptation to fast lung tumor motion for couch tracking and to prostate motion perpendicular to the MLC leaves for MLC tracking. Conclusions: Couch and MLC tracking markedly improved the geometric and dosimetric accuracies of VMAT delivery. However, the two tracking types have different strengths and weaknesses. While couch tracking can correct perfectly for slowly moving targets such as the prostate, MLC tracking may have considerably larger dose errors for persistent target shift perpendicular to the MLC leaves. Advantages of MLC tracking include faster dynamics with better adaptation to fast moving targets, the avoidance of moving the patient, and the potential to track target rotations and deformations.

60 APPLIED LIFE SCIENCES↗

The Influence of Adaptive Mesh Refinement on the Prediction of Vortex Interactions about a Generic Missile Airframe

The complex interaction of forebody and wing vortices significantly impacts missile aerodynamics. The formation of these vortices involves smooth regions of the geometry or geometric discontinuities like leading edges, trailing edges, tips, and corners. Regions of supersonic flow and complex shock topologies interact with boundary layers and vortices. Smooth-body separation and 3D viscous effects strain current Reynolds-averaged Navier-Stokes (RANS) techniques. The quantification and control of discretization error is critical to obtaining reliable simulation results and often turbulence model assessments are made in the presence of unquantified (and potentially large) discretization errors. Two mesh adaptation schemes are applied to steady RANS simulations. Multiscale unstructured mesh adaptation is applied to control interpolation error estimates of the Mach field, which resolves boundary layers, vortices, and shocks. A dual-mesh approach with overset communication is applied between an expert-crafted near-body unstructured mesh and an adaptive off-body Cartesian mesh refined with Q-criterion scaled by the strain tensor magnitude. A generic missile configuration is examined in a supersonic flow field to show the interaction of mesh adaptation and turbulence model. Turbulence model modifications for rotational correction and a quadratic constitutive relationship show a strong influence on adaptive mesh refinement and predicted rolling moment.

slender body aerodynamics↗

Online Adaptive Radiation Therapy

The current paradigm of radiation therapy has the treatment planned on a snapshot dataset of the patient's anatomy taken at the time of simulation. Throughout the course of treatment, this snapshot may vary from initial simulation. Although there is the ability to image patients within the treatment room with technologies such as cone beam computed tomography, the current state of the art is largely limited to rigid-body matching and not accounting for any geometric deformations in the patient's anatomy. A plan that was once attuned to the initial simulation can become suboptimal as the treatment progresses unless improved technologies are brought to bear. Adaptive radiation therapy (ART) is an evolving paradigm that seeks to address this deficiency by accounting for ongoing changes in the patient's anatomy and/or physiology during the course of treatment, affording an increasingly more accurate targeting of disease. ART relies on several components working in concert, namely in-room treatment image guidance, deformable image registration, automatic recontouring, plan evaluation and reoptimization, dose calculation, and quality assurance. Various studies have explored how a putative ART solution would improve the current state of the art of radiation therapy—some centers have even clinically implemented online adaptation. These explorations are reviewed here for a variety of sites.

62 RADIOLOGY AND NUCLEAR MEDICINE↗

On the global dynamics of adaptive systems - A study of an elementary example

The inherent nonlinear character of adaptive systems poses serious theoretical problems for the analysis of their dynamics. On the other hand, the importance of their dynamic behavior is directly related to the practical interest in predicting such undesirable phenomena as nonlinear oscillations, abrupt transients, intermittence or a high sensitivity with respect to initial conditions. A geometrical/qualitative description of the phase portrait of a discrete-time adaptive system with unmodeled disturbances is given. For this, the motions in the phase space are referred to normally hyperbolic (structurally stable) locally invariant sets. The study is complemented with a local stability analysis of the equilibrium point and periodic solutions. The critical character of adaptive systems under rather usual working conditions is discussed. Special emphasis is put on the causes leading to intermittence. A geometric interpretation of the effects of some commonly used palliatives to this problem is given. The 'dead-zone' approach is studied in more detail. The predicted dynamics are compared with simulation results.

Espana, Martin D.↗

Auto-adaptive finite element meshes

Accurate capturing of discontinuities within compressible flow computations is achieved by coupling a suitable solver with an automatic adaptive mesh algorithm for unstructured triangular meshes. The mesh adaptation procedures developed rely on non-hierarchical dynamical local refinement/derefinement techniques, which hence enable structural optimization as well as geometrical optimization. The methods described are applied for a number of the ICASE test cases are particularly interesting for unsteady flow simulations.

Richter, Roland↗