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At least 163 records · Page 9
All sourcesNASA NTRSDOE OSTI
DOE OSTI2021

Perceptions of Seasonal Influenza Vaccine Among U.S. Army Civilians and Dependents in the Kaiserslautern Military Community: A Mixed-Methods Survey

ABSTRACT Introduction Influenza is a globally occurring viral respiratory infection that can lead to hospitalizations and death. An influenza outbreak can interfere with combat readiness in a military setting, as the infection can incapacitate soldiers. Vaccination remains the most effective tool to prevent and mitigate seasonal influenza. Although influenza vaccinations for U.S. Army soldiers can be monitored through military health systems, those systems cannot capture DoD civilians and Army dependents who may not use military health services. This study aims to gauge flu vaccine uptake and perceptions in U.S. Army civilians and dependents. Materials and Methods An online survey was e-mailed to civilian and dependent enrollees of Landstuhl Regional Medical Center. The survey contained 24 questions pertaining to demographics, vaccine history, history of the flu, and beliefs toward vaccines. Chi-square tests, t-tests, and logistic regressions were performed to investigate the association between demographic, behavior, and belief factors with vaccine uptake. Free-text answers were coded and categorized by themes. Results Over 70% of respondents were vaccinated for the flu. There were differences between vaccinated and unvaccinated respondents regarding their perceptions of barriers to vaccination, benefits of the flu vaccine, severity of flu symptoms, and personal risk of getting ill with the flu. After controlling for confounders, flu vaccination in the previous season and healthcare worker status were associated with increased vaccine uptake, while perceived barriers to influenza vaccination were associated with decreased vaccine uptake. Conclusions Flu vaccine uptake may be increased by increasing access to vaccination, promoting vaccination and addressing concerns at the provider level, and engaging positively framed public messaging. Increasing flu vaccine uptake is of particular importance as the flu season approaches during the COVID-19 (Coronavirus disease 2019) pandemic.

Burns, MSC, Veronica M.↗
DOE OSTI2020

A genoscape–network model for conservation prioritization in a migratory bird

Migratory animals are declining worldwide and coordinated conservation efforts are needed to reverse current trends. We devised a novel genoscape-network model that combines genetic analyses with species distribution modeling and demographic data to overcome challenges with conceptualizing alternative risk factors in migratory species across their full annual cycle. We applied our method to the long distance, Neotropical migratory bird, Wilson's Warbler (Cardellina pusilla). Despite a lack of data from some wintering locations, we demonstrated how the results can be used to help prioritize conservation of breeding and wintering areas. For example, we showed that when genetic, demographic, and network modeling results were considered together it became clear that conservation recommendations will differ depending on whether the goal is to preserve unique genetic lineages or the largest number of birds per unit area. More specifically, if preservation of genetic lineages is the goal, then limited resources should be focused on preserving habitat in the California Sierra, Basin Rockies, or Coastal California, where the 3 most vulnerable genetic lineages breed, or in western Mexico, where 2 of the 3 most vulnerable lineages overwinter. Alternatively, if preservation of the largest number of individuals per unit area is the goal, then limited conservation dollars should be placed in the Pacific Northwest or Central America, where densities are estimated to be the highest. Overall, our results demonstrated the utility of adopting a genetically based network model for integrating multiple types of data across vast geographic scales and better inform conservation decision-making for migratory animals.

60 APPLIED LIFE SCIENCES↗
DOE OSTI2020

Estimation of Body Fat Percentage for Clinical Pharmacokinetic Studies in Children

Obesity is a prevalent childhood condition and the degree of adiposity appears likely to be an important covariate in the pharmacokinetics (PKs) of many drugs. We undertook these studies to facilitate the evaluation and, where appropriate, quantification of the covariate effect of body fat percentage (BF%) on PK parameters in children. We examined two large databases to determine the values and variabilities of BF% in children with healthy body weights and in those with obesity, comparing the accuracy and precision of BF% estimation by both clinical methods and demographically derived techniques. Additionally, we conducted simulation studies to evaluate the utility of the several methods for application in clinical trials. BF% was correlated with body mass index (BMI), but was highly variable among both children with healthy body weights and those with obesity. Bio‐impedance and several demographically derived techniques produced mean estimates of BF% that differed from dual x‐ray absorptiometry by < 1% (accuracy) and a SD of 5% or less (precision). Simulation studies confirmed that when the differences in precision among the several methods were small compared with unexplained between‐subject variability of a PK parameter, the techniques were of similar value in assessing the contribution of BF%, if any, as a covariate for that PK parameter. The combination of sex and obesity stage explained 68% of the variance of BF% with BMI. The estimation of BF% from sex and obesity stage can routinely be applied to PK clinical trials to evaluate the contribution of BF% as a potential covariate.

Green, Thomas P.↗
DOE OSTI2020

Pervasive shifts in forest dynamics in a changing world

Forest dynamics arise from the interplay of environmental drivers and disturbances with the demographic processes of recruitment, growth, and mortality, subsequently driving biomass and species composition. However, forest disturbances and subsequent recovery are shifting with global changes in climate and land use, altering these dynamics. Changes in environmental drivers, land use, and disturbance regimes are forcing forests toward younger, shorter stands. Rising carbon dioxide, acclimation, adaptation, and migration can influence these impacts. Recent developments in Earth system models support increasingly realistic simulations of vegetation dynamics. In parallel, emerging remote sensing datasets promise qualitatively new and more abundant data on the underlying processes and consequences for vegetation structure. In combination, these advances hold promise for improving the scientific understanding of changes in vegetation demographics and disturbances.

54 ENVIRONMENTAL SCIENCES↗
DOE OSTI2026

Predictive analytics to direct clinical attention to complex patients with elevated suicide risk: enhancement of the Veterans Health Administration REACH VET model

Suicide is a major public health concern, particularly among Veterans. The U.S. Department of Veterans Affairs Veterans Health Administration (VHA) employs the Recovery Engagement and Coordination for Health–Veterans Enhanced Treatment (REACH VET) model to prioritise high-risk patients for targeted clinical attention. REACH VET 1.0 (RV 1.0) was developed on 2008–2011 data. To reflect changes in clinical practice and populations, VHA updated it to REACH VET 2.0 (RV 2.0). This study describes its development and validation. RV 2.0 used longitudinal data from 7,248,170 VHA patients (4,967 suicide deaths) in 2018–2019, with 650 time-varying demographic, clinical and area-level predictors derived from a 2-year lookback (2016–2019). An ensemble of Elastic-Net logistic regression models was trained on 2018 data and evaluated monthly at the population level in 2019, focusing on the top 0.1% intervention risk tier. Analyses assessed model discrimination, suicide detection, risk concentration, subgroup consistency (sex, age and race/ethnicity) and performance relative to RV 1.0 using the same percentile-based risk strata. RV 2.0 outperformed RV 1.0 across all risk strata, with better discrimination (C-statistic 0.76 vs 0.69) and consistent performance across demographic subgroups. Within the top 0.1% of predicted risk, RV 2.0 identified more deaths, higher suicide rates and greater mortality risk concentration both when averaged across the 12 monthly 2019 test sets (5.6 vs 3.6; 83.6 vs 53.7 per 100,000 person-years; 21.0 vs 14.1) and when annualised for 2019 (67 vs 43; 2.7% vs 1.7%; 1,003 vs 644 per 100,000 person-years; 26.7 vs 17.1). RV 2.0 improves suicide risk stratification among Veterans, demonstrating better performance and consistent prediction across subgroups and highlighting the need for regular model updates and evaluation.

Peluso, Alina [Oak Ridge National Laboratory (ORNL↗
DOE OSTI2023

Risk Factors and Trends for HPV-Associated Subsequent Malignant Neoplasms among Adolescent and Young Adult Cancer Survivors

Subsequent malignant neoplasms (SMN; new cancers that arise after an original diagnosis) contribute to premature mortality among adolescent and young adult (AYA) cancer survivors. Because of the high population prevalence of human papillomavirus (HPV) infection, we identify demographic and clinical risk factors for HPV-associated SMNs (HPV-SMN) among AYA cancer survivors in the SEER-9 registries diagnosed from 1976 to 2015. Outcomes included any HPV-SMN, oropharyngeal-SMN, and cervical-SMN. Follow-up started 2 months after their original diagnosis. Standardized incidence ratios (SIR) compared risk between AYA survivors and general population. Age-period-cohort (APC) models examined trends over time. Fine and Gray's models identified therapy effects controlling for cancer and demographic confounders. Of 374,408 survivors, 1,369 had an HPV-SMN, occurring on average 5 years after first cancer. Compared with the general population, AYA survivors had 70% increased risk for any HPV-SMN [95% confidence interval (CI), 1.61–1.79] and 117% for oropharyngeal-SMN (95% CI, 2.00–2.35); cervical-SMN risk was generally lower in survivors (SIR, 0.85; 95% CI, 0.76–0.95), but Hispanic AYA survivors had a 8.4 significant increase in cervical-SMN (SIR, 1.46; 95% CI, 1.01–2.06). AYAs first diagnosed with Kaposi sarcoma, leukemia, Hodgkin, and non-Hodgkin lymphoma had increased HPV-SMN risks compared with the general population. Oropharyngeal-SMN incidence declined over time in APC models. Chemotherapy and radiation were associated with any HPV-SMN among survivors with first HPV-related cancers, but not associated among survivors whose first cancers were not HPV-related. HPV-SMN in AYA survivors are driven by oropharyngeal cancers despite temporal declines in oropharyngeal-SMN. Hispanic survivors are at risk for cervical-SMN relative to the general population. Encouraging HPV vaccination and cervical and oral cancer screenings may reduce HPV-SMN burden among AYA survivors.

60 APPLIED LIFE SCIENCES↗
DOE OSTI2024

Existing evidence on the effects of climate variability and climate change on ungulates in North America: a systematic map

Abstract Background Climate is an important driver of ungulate life-histories, population dynamics, and migratory behaviors. Climate conditions can directly impact ungulates via changes in the costs of thermoregulation and locomotion, or indirectly, via changes in habitat and forage availability, predation, and species interactions. Many studies have documented the effects of climate variability and climate change on North America’s ungulates, recording impacts to population demographics, physiology, foraging behavior, migratory patterns, and more. However, ungulate responses are not uniform and vary by species and geography. Here, we present a systematic map describing the abundance and distribution of evidence on the effects of climate variability and climate change on native ungulates in North America. Methods We searched for all evidence documenting or projecting how climate variability and climate change affect the 15 ungulate species native to the U.S., Canada, Mexico, and Greenland. We searched Web of Science, Scopus, and the websites of 62 wildlife management agencies to identify relevant academic and grey literature. We screened English-language documents for inclusion at both the title and abstract and full-text levels. Data from all articles that passed full-text review were extracted and coded in a database. We identified knowledge clusters and gaps related to the species, locations, climate variables, and outcome variables measured in the literature. Review findings We identified a total of 674 relevant articles published from 1947 until September 2020. Caribou ( Rangifer tarandus ), elk ( Cervus canadensis ), and white-tailed deer ( Odocoileus virginianus ) were the most frequently studied species. Geographically, more research has been conducted in the western U.S. and western Canada, though a notable concentration of research is also located in the Great Lakes region. Nearly 75% more articles examined the effects of precipitation on ungulates compared to temperature, with variables related to snow being the most commonly measured climate variables. Most studies examined the effects of climate on ungulate population demographics, habitat and forage, and physiology and condition, with far fewer examining the effects on disturbances, migratory behavior, and seasonal range and corridor habitat. Conclusions The effects of climate change, and its interactions with stressors such as land-use change, predation, and disease, is of increasing concern to wildlife managers. With its broad scope, this systematic map can help ungulate managers identify relevant climate impacts and prepare for future changes to the populations they manage. Decisions regarding population control measures, supplemental feeding, translocation, and the application of habitat treatments are just some of the management decisions that can be informed by an improved understanding of climate impacts. This systematic map also identified several gaps in the literature that would benefit from additional research, including climate effects on ungulate migratory patterns, on species that are relatively understudied yet known to be sensitive to changes in climate, such as pronghorn ( Antilocapra americana ) and mountain goats ( Oreamnos americanus ), and on ungulates in the eastern U.S. and Mexico.

Malpeli, Katherine C. (ORCID:000000030780918X)↗
DOE OSTI2020

Development and validation of a 30-day mortality index based on pre-existing medical administrative data from 13,323 COVID-19 patients: The Veterans Health Administration COVID-19 (VACO) Index

Background Available COVID-19 mortality indices are limited to acute inpatient data. Using nationwide medical administrative data available prior to SARS-CoV-2 infection from the US Veterans Health Administration (VA), we developed the VA COVID-19 (VACO) 30-day mortality index and validated the index in two independent, prospective samples. Methods and findings We reviewed SARS-CoV-2 testing results within the VA between February 8 and August 18, 2020. The sample was split into a development cohort (test positive between March 2 and April 15, 2020), an early validation cohort (test positive between April 16 and May 18, 2020), and a late validation cohort (test positive between May 19 and July 19, 2020). Our logistic regression model in the development cohort considered demographics (age, sex, race/ethnicity), and pre-existing medical conditions and the Charlson Comorbidity Index (CCI) derived from ICD-10 diagnosis codes. Weights were fixed to create the VACO Index that was then validated by comparing area under receiver operating characteristic curves (AUC) in the early and late validation cohorts and among important validation cohort subgroups defined by sex, race/ethnicity, and geographic region. We also evaluated calibration curves and the range of predictions generated within age categories. 13,323 individuals tested positive for SARS-CoV-2 (median age: 63 years; 91% male; 42% non-Hispanic Black). We observed 480/3,681 (13%) deaths in development, 253/2,151 (12%) deaths in the early validation cohort, and 403/7,491 (5%) deaths in the late validation cohort. Age, multimorbidity described with CCI, and a history of myocardial infarction or peripheral vascular disease were independently associated with mortality–no other individual comorbid diagnosis provided additional information. The VACO Index discriminated mortality in development (AUC = 0.79, 95% CI: 0.77–0.81), and in early (AUC = 0.81 95% CI: 0.78–0.83) and late (AUC = 0.84, 95% CI: 0.78–0.86) validation. The VACO Index allows personalized estimates of 30-day mortality after COVID-19 infection. For example, among those aged 60–64 years, overall mortality was estimated at 9% (95% CI: 6–11%). The Index further discriminated risk in this age stratum from 4% (95% CI: 3–7%) to 21% (95% CI: 12–31%), depending on sex and comorbid disease. Conclusion Prior to infection, demographics and comorbid conditions can discriminate COVID-19 mortality risk overall and within age strata. The VACO Index reproducibly identified individuals at substantial risk of COVID-19 mortality who might consider continuing social distancing, despite relaxed state and local guidelines.

60 APPLIED LIFE SCIENCES↗
DOE OSTI2026

1997/1998 Regional Travel Household Interview Survey

The 1997/1998 Regional Travel—Household Interview Survey was conducted in the 28-county New York-New Jersey-Connecticut metropolitan area, including 12 counties in New York, 14 counties in New Jersey, and 2 counties in Connecticut. The study was jointly funded by the New York Metropolitan Transportation Council and the North Jersey Transportation Planning Authority (NJTPA). The purpose of the survey was to provide information suitable for gaining an in-depth understanding of the travel behavior of households and individuals, as well as the activities, demographics, and other factors that affect such behavior. The survey was a diary-type travel survey, in which detailed travel information and basic demographic and socioeconomic features were collected for each member of the 11,264 participating households during an entire travel day. The sample for analysis of resident-based weekday travel is 10,971 for the entire 28-county metro area. The weekend sample, comprised of 275 households, is restricted to the NJTPA counties of northern New Jersey and compliments the results of the 1995 Nationwide Personal Transportation Survey for the entire area.

1Hz data↗
DOE OSTI2026

Sacramento Area Council of Governments's 1991 Household Travel Survey

The Sacramento Area Council of Governments's 1991 Household Travel Survey was conducted in conjunction with the California State Department of Transportation, and provides a detailed survey of travel behavior of 3,942 households in the Sacramento region. The region includes all of Sacramento, Yolo, Yuba, and Sutter counties, as well as the western portions of Placer and El Dorado counties. The purpose of the survey was to obtain up-to-date information on the socioeconomic, demographic, and travel characteristics of the population. During their travel day, participating household members were asked to record travel information in a diary for the specified 24-hour period. The information documented by respondents includes trip activities, mode of transportation, trip times, and trip location. Demographic information includes gender, age, employment status, household income, and household size, as well as whether the respondent held a valid driver's license, whether the respondent was a student, and whether the respondent owned or rented a home.

1Hz data↗
DOE OSTI2026

1996 Bay Area Travel Study Wave 2

The 1996 Bay Area Travel Study, conducted by the Metropolitan Transportation Commssion, collected demographic, socioeconomic, and travel data for 3,618 households in California's nine-county Bay Area: Alameda, Contra Costa, Marin, Napa, San Francisco, San Mateo, Santa Clara, Solano, and Sonoma counties. The goal of the study was to collect information on activities for all people in each household, regardless of age or relationship. Respondents were asked to record all activities, including trips, over a two-day period. The data gathered during the survey will be used for the area's long-term transportation and air quality planning needs. The survey collected both weekday and weekend multi-day data and was the first activity-based survey conducted in the Bay Area. It also included separate sub-projects. A stated preference congestion pricing survey was administered to 150 of the respondents with a follow-up survey conducted with 110 participants. A follow-up survey was also completed by over half of the 3,618 respondent households to update contact and demographic information. These participants were then used as a panel sample for the 2000 Bay Area Travel Survey (NuStats Research and Consulting 1999).

1Hz data↗
DOE OSTI2026

1992 Seattle Household Travel Survey Wave 3

The Seattle Household Travel Survey Wave 3, conducted in 1992, was the third wave in a ten-part longitudinal panel survey initiated by the Puget Sound Regional Council to assess the travel patterns of households in the Puget Sound region of Washington state. This collection contains the third set of panel data for approximately 1,700 households in King, Kitsap, Pierce, and Snohomish counties. Due to various sources of attrition, approximately 20% of households needed to be replaced for each survey wave. The survey relied on the willingness of study area residents to 1) provide demographic information about their household, its members, and its vehicles; 2) document all travel for each household member, aged 15 years or older, for an assigned two-day period; and 3) agree to participate in additional survey waves. After an initial telephone screening, survey participants received mailed travel diaries to aid in documenting travel information for the two-day assessment period. Respondents were instructed to record their mode of transportation, trip purpose, number of vehicle passengers, departure and arrival times, ride fare, and parking costs. Demographic information for this study includes age, gender, education, employment status, and household income.

1Hz data↗
DOE OSTI2026

1994 Seattle Household Travel Survey Wave 5

The Seattle Household Travel Survey Wave 5, conducted in 1994, was the fifth wave in a ten-part longitudinal panel survey of the travel patterns of households in the Puget Sound region of Washington state. The survey series was initiated in 1989 by the Puget Sound Regional Council. This collection contains the fifth set of panel data for approximately 2,000 households in King, Kitsap, Pierce, and Snohomish counties. The survey relied on the willingness of study area residents to 1) provide demographic information about their household, its members, and its vehicles; 2) document all travel for each household member, aged 15 years or older, for an assigned two-day period; and 3) agree to participate in additional survey waves. After an initial telephone screening, survey participants received mailed travel diaries to aid in documenting travel information for the two-day assessment period. Respondents were instructed to record their mode of transportation, trip purpose, number of passengers, departure and arrival times, ride fare, and parking costs. Demographic information for this study includes age, gender, education, employment status, and household income.

1Hz data↗
DOE OSTI2026

1996 Seattle Household Travel Survey Wave 6

The Seattle Household Travel Survey Wave 6, conducted in the second and third quarters of 1996, was the sixth wave in a ten-part longitudinal panel survey of the travel patterns of households in the Puget Sound region of Washington state. The survey series was initiated in 1989 by the Puget Sound Regional Council. This collection contains the sixth set of panel data for approximately 2,000 households in King, Kitsap, Pierce, and Snohomish counties. Due to various sources of attrition, approximately 20% of households needed to be replaced for each survey wave. The survey relied on the willingness of study area residents to 1) provide demographic information about their household, its members, and its vehicles; 2) document all travel for each household member, aged 15 years or older, for an assigned two-day period; and 3) agree to participate in additional survey waves. After an initial telephone screening, survey participants received mailed travel diaries to aid in documenting travel information for the two-day assessment period. Respondents were instructed to record their mode of transportation, trip purpose, number of vehicle passengers, departure and arrival times, ride fare, and parking costs. Demographic information for this study includes age, gender, education, employment status, and household income.

1Hz data↗
DOE OSTI2026

1997 Seattle Household Travel Survey Wave 7

The Seattle Household Travel Survey Wave 7, conducted in 1997, was the seventh wave in a ten-part longitudinal panel survey initiated by the Puget Sound Regional Council to assess the travel patterns of households in the Puget Sound region of Washington state. This collection contains the seventh set of panel data for approximately 1,700 households in King, Kitsap, Pierce, and Snohomish counties. The survey relied on the willingness of study area residents to 1) provide demographic information about their household, its members, and its vehicles; 2) document all travel for each household member, aged 15 years or older, for an assigned two-day period; and 3) agree to participate in additional survey waves. After an initial telephone screening, survey participants received mailed travel diaries to aid in documenting travel information for the two-day assessment period. Respondents were instructed to record their mode of transportation, trip purpose, number of vehicle passengers, departure and arrival times, ride fare, and parking costs. Demographic information for this study includes age, gender, education, employment status, and household income.

1Hz data↗
DOE OSTI2026

2000 Seattle Household Travel Survey Wave 9

The Seattle Household Travel Survey Wave 9, conducted in 2000, was the ninth wave in a ten-part longitudinal panel survey of the travel patterns of households in the Puget Sound region of Washington state. The survey series was initiated in 1989 by the Puget Sound Regional Council. This collection contains the ninth set of panel data for approximately 2,000 households in King, Kitsap, Pierce, and Snohomish counties. Due to various sources of attrition, approximately 20% of households needed to be replaced for each survey wave. The survey relied on the willingness of study area residents to 1) provide demographic information about their household, its members, and its vehicles; 2) document all travel for each household member, aged 15 years or older, for an assigned two-day period; and 3) agree to participate in additional survey waves. After an initial telephone screening, survey participants received mailed travel diaries to aid in documenting travel information for the two-day assessment period. Respondents were instructed to record their mode of transportation, trip purpose, number of passengers, departure and arrival times, ride fare, and parking costs. Demographic information for this study includes age, gender, education, employment status, and household income.

1Hz data↗
DOE OSTI2026

2002 Seattle Household Travel Survey Wave 10

The Seattle Household Travel Survey Wave 10, conducted in 2002, was the tenth wave in a ten-part longitudinal panel survey of the travel patterns of households in the Puget Sound region of Washington state. The survey series was initiated in 1989 by the Puget Sound Regional Council. This collection contains the tenth set of panel data for approximately 2,000 households in King, Kitsap, Pierce, and Snohomish counties. The survey relied on the willingness of study area residents to 1) provide demographic information about their household, its members, and its vehicles; 2) document all travel for each household member, aged 15 years or older, for an assigned two-day period; and 3) agree to participate in additional survey waves. After an initial telephone screening, survey participants received mailed travel diaries to aid in documenting travel information for the two-day assessment period. Respondents were instructed to record their mode of transportation, trip purpose, number of passengers, departure and arrival times, ride fare, and parking costs. Demographic information for this study includes age, gender, education, employment status, and household income.

1Hz data↗
DOE OSTI2026

2002 St. Louis Region Travel Survey

The 2002 St. Louis Household Travel Survey entailed the collection of weekday travel behavior characteristics of households residing in each of the eight counties that comprise the St. Louis region. In addition to collecting basic demographic and socioeconomic information about each household and its members, the survey documented specific characteristics of activities and trips, including the number and purpose of trips, trip duration, time of day, mode of transportation, and specifics of school- and work-related travel. The survey instruments contained three components: 1) the recruitment questionnaire, 2) the travel log, and 3) the retrieval questionnaire. In total, 7,046 households were recruited to participate in the study via telephone interview. Of these, 5,094 completed travel logs during a specific 24-hour period, and the information was retrieved from all household members, regardless of age. Demographic information for this study includes age, gender, education level, employment status, and household income.

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