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At least 163 records · Page 9

Imaging crossing fibers in mouse, pig, monkey, and human brain using small-angle X-ray scattering

Myelinated axons (nerve fibers) efficiently transmit signals throughout the brain via action potentials. Multiple methods that are sensitive to axon orientations, from microscopy to magnetic resonance imaging, aim to reconstruct the brain's structural connectome. As billions of nerve fibers traverse the brain with various possible geometries at each point, resolving fiber crossings is necessary to generate accurate structural connectivity maps. However, doing so with specificity is a challenging task because signals originating from oriented fibers can be influenced by brain (micro)structures unrelated to myelinated axons. X-ray scattering can specifically probe myelinated axons due to the periodicity of the myelin sheath, which yields distinct peaks in the scattering pattern. Here, in this work, we show that small-angle X-ray scattering (SAXS) can be used to detect myelinated, axon-specific fiber crossings. We first demonstrate the capability using strips of human corpus callosum to create artificial double- and triple-crossing fiber geometries, and we then apply the method in mouse, pig, vervet monkey, and human brains. We compare results to polarized light imaging (3D-PLI), tracer experiments, and to outputs from diffusion MRI that sometimes fails to detect crossings. Given its specificity, capability of 3-dimensional sampling and high resolution, SAXS could serve as a ground truth for validating fiber orientations derived using diffusion MRI as well as microscopy-based methods.

59 BASIC BIOLOGICAL SCIENCES↗

Nonadiabatic transitions during a passage near a critical point

The passage through a critical point of a many-body quantum system leads to abundant nonadiabatic excitations. Here, we explore a regime, in which the critical point is not crossed although the system is passing slowly very close to it. Here, we show that the leading exponent for the excitation probability can then be obtained by standard arguments of the Dykhne formula, but the exponential prefactor is no longer simple and behaves as a power law on the characteristic transition rate. We derive this prefactor for the nonlinear Landau–Zener model by adjusting Dykhne’s approach. Then, we introduce an exactly solvable model of the transition near a critical point in the Stark ladder. We derive the number of excitations for it without approximations and find qualitatively similar results for the excitation scaling.

37 INORGANIC, ORGANIC, PHYSICAL, AND ANALYTICAL CH↗

Implosion mediated gas-puff hybrid X-pinch

Imploding gas-puff z-pinches are efficient sources of intense X-rays. However, the unpredictable size, number, and location of hot-spots along the pinch axis make them unsuitable for applications such as point-projection radiography. Crossed wire or hybrid X-pinches on the other hand provide small, localized sources but require fast current rise times and must be reloaded after each pulse. In this letter, we present the first experimental demonstration of an implosion mediated gas-puff hybrid x-pinch in which an annular gas-puff implosion is shaped and focused onto pair of conical electrodes separated by a small gap. Here, this setup produces an intense X-ray source with controllable timing that can be operated with or without a central wire. Because the gas-puff implosion time determines the formation of the pinch, this configuration can continue to operate efficiently as a point X-ray source for longer current pulses than conventional x-pinches.

70 PLASMA PHYSICS AND FUSION TECHNOLOGY↗

Constraints on primordial non-Gaussianity from the cross-correlation of DESI luminous red galaxies and Planck CMB lensing

We use the angular cross-correlation between a luminous red galaxy (LRG) sample from the Dark Energy Spectroscopic Instrument (DESI) Legacy Survey data release DR9 and the Planck cosmic microwave background (CMB) lensing maps to constrain the local primordial non-Gaussianity parameter, f NL , using the scale-dependent galaxy bias effect. The galaxy sample covers approximately 40% of the sky, contains galaxies up to redshift z ∼ 1.4, and is calibrated with the LRG spectra that have been observed for DESI Year 1 (Y1). We apply a nonlinear imaging systematics treatment based on neural networks to remove observational effects that could potentially bias the f NL measurement. Our measurement is performed without blinding, but the full analysis pipeline is tested with simulations including systematics. Using the two-point angular cross-correlation between LRG and CMB lensing only, we find f NL = 39 −38 +40 at the 68% confidence level, and our result is robust in terms of systematics and cosmological assumptions. If we combine this information with the autocorrelation of LRG, applying a scale cut to limit the impact of systematics, we find f NL = 24 −21 +20 at the 68% confidence level. Our results motivate the use of CMB lensing cross-correlations to measure f NL with future datasets, given its stability in terms of observational systematics compared to the angular autocorrelation. Furthermore, performing accurate systematics mitigation is crucially important in order to achieve competitive constraints on f NL from CMB lensing cross-correlation in combination with the tracers’ autocorrelation.

79 ASTRONOMY AND ASTROPHYSICS↗

Defect Generation and Evolution in Irradiated Epitaxial Films and Heterostructures of Fe 3 O 4 and Cr 2 O 3

Abstract The functionality of nuclear structural materials, sensors, and microelectronics in harsh environments such as radiation relies on understanding defect generation and evolution processes in oxide layers. The initial radiation response of epitaxial thin films of Fe 3 O 4 (111), Cr 2 O 3 (0001), and Fe 3 O 4 (111)/Cr 2 O 3 (0001) heterostructures deposited on Al 2 O 3 (0001) by oxygen‐assisted molecular beam epitaxy and irradiated with 200 keV He + is characterized. X‐ray diffraction and X‐ray absorption near edge spectroscopy showed that the Cr 2 O 3 layers underwent significant lattice expansion and disordering under irradiation, whereas the Fe 3 O 4 layers do not exhibit noticeable changes. In contrast, positron annihilation spectroscopy revealed an evolution of cation vacancy point defects in the Fe 3 O 4 layers into larger vacancy clusters with increasing irradiation, while the cation vacancies in Cr 2 O 3 remained primarily as single vacancies and small clusters. The results suggest that the Fe 3 O 4 lattice can utilize the free volume of the larger vacancy clusters to relax but the small vacancies in the Cr 2 O 3 lattice do not facilitate relaxation. Comparing defect concentrations in the single layer films versus the heterostructure suggests that point defects may cross the interface from Fe 3 O 4 into Cr 2 O 3 . Together, these results enhance the understanding of the initial defect evolution mechanisms in oxide layers in harsh irradiation environments.

36 MATERIALS SCIENCE↗

Development of a Route Crossing Tool for Shared Airspace Environments

In current-day Terminal Radar Approach Control (TRACON) operations, departure and arrival controllers maintain separate and dedicated airspace for their respective traffic flows. Although this practice has obvious safety features, it also leads to inefficiencies; for example, departure aircraft may be routinely capped beneath arrival airspace. With the right decision-support and coordination tools, departures could continue to climb through arrival airspace when sufficient gaps exist. Previous studies of ‘shared airspace’ have examined pre-arranged coordination procedures, as well as tools that gave feedback to the controllers on where gaps between arrivals were located and whether the departure aircraft could be scheduled to fly through those gaps [1, 2, 3, 4]. Since then, the Route Crossing Tool (RCT) has been developed to allow controllers to assess multiple pre-defined route options at points where the arrivals and departures cross, thereby increasing the possibility of climbing a departure through an arrival gap.The RCT aids in ensuring lateral separation between departure and arrival aircraft that pass through the same altitude. Since the RCT can be applied tactically, it can enable aircraft to fly through arrival flows even if these aircraft depart outside scheduled times. The RCT makes use of a set of predefined parallel departure routes crossing the arrival flow at equidistant intersecting points on the arrival route. The RCT uses the Estimated Time of Arrival (ETA) of the departure aircraft at each intersecting point to calculate the lateral separation with the neighboring arrivals when it crosses that point; this information is graphically displayed to the controller. Additionally, the RCT incorporates forecast winds in its ETA predictions.Multiple prototypes of the RCT have been iteratively developed with feedback from Subject Matter Experts (SMEs). This paper presents the final design, the design process, and lessons learned. Initial results from a simulation suggest that the tool was successful in helping controllers to safely climb more aircraft. Controller feedback on the tool was also positive.

shared airspace↗

Intrinsic Berry curvature driven anomalous Nernst thermopower in the semimetallic Heusler alloy CoFeVSb

Understanding of spin-heat coupling mechanisms and magnetothermoelectric phenomena, including the anomalous Nernst effect (ANE), in emergent quaternary Heusler alloys is of practical importance for applications in thermal management and energy harvesting. Here, we demonstrate an intrinsic Berry curvature mediated anomalous Nernst thermopower in CoFeVSb, which orders magnetically at high temperature ( T C ≈ 850 K ) with a large saturation magnetization of ≈ 2.2 μ B / f . u . at room temperature. We show that the electron-electron elastic and electron-magnon inelastic scattering dominate longitudinal electrical transport at low temperatures ( T ≤ 50 K ), whereas the electron-phonon and electron-magnon scatterings govern it at higher T . The longitudinal thermopower is resulted mainly from the diffusive contribution with a very large longitudinal Seebeck coefficient ( 42 μ V K - 1 at 395 K). The value of the anomalous Nernst coefficient ( S ANE ) for CoFeVSb at room temperature is 0.039 μ V K - 1 which is higher than the compressively strained SrRu O 3 film ( 0.03 μ V K - 1 ) as well as the spin gapless semiconductor CoFeCrGa ( 0.018 μ V K - 1 ). On lowering T , both the ordinary Nernst coefficient and carrier mobility increase but an opposite trend is found for S ANE . Our ab initio simulations reveal the topological semimetallic nature of CoFeVSb with a pair of Weyl points. These Weyl crossings result in a significant contribution to the Berry curvature, leading to an intrinsic anomalous Hall conductivity ( σ x y AHE ) of ≈ 85 S/cm, which matches well with experiment (77 S/cm at 2 K). Our experimental findings and ab initio calculations support the dominance of the intrinsic Berry curvature in the observed ANE. The ratio of σ x y AHE to the transverse anomalous thermoelectric conductivity ( α x y ANE ) shows an increasing trend with T attaining a sizable fraction of k B e ( ≈ 0.35 k B e ) at room temperature.

36 MATERIALS SCIENCE↗

Local measurements in turbulent flows through cross correlation of optical signals

Crossed beam correlation method measures turbulent fluctuations in transonic and supersonic flows. Two collimated beams of radiation are crossed at the point of interest in the flow, and the power loss of each beam is measured with two independent photodetectors, which yield information about the turbulent properties.

Fisher, M. J.↗

The anatomy of floating shock fitting

The floating shock fitting technique is examined. Second-order difference formulas are developed for the computation of discontinuities. A procedure is developed to compute mesh points that are crossed by discontinuities. The technique is applied to the calculation of internal two-dimensional flows with arbitrary number of shock waves and contact surfaces. A new procedure, based on the coalescence of characteristics, is developed to detect the formation of shock waves. Results are presented to validate and demonstrate the versatility of the technique.

Salas, M. D.↗

Structure of the conical flowfield about external axial corners

A theoretical and experimental investigation of the flowfield about symmetrical and asymmetrical external axial corners formed by the juncture of swept compressive wedges is presented. A study is made of the nature of inviscid cross flow stagnation points and their dependence on certain flow parameters is derived. The importance of imposing the physically relevant boundary condition for numerical simulations is discussed. For the asymmetrical wedge configuration, the proper boundary condition along the axial corner is shown to be a conical analog of Prandtl-Meyer flow. Further insight into the flow structure is revealed by the experimental results.

Salas, M. D.↗

Careful numerical study of flowfields about asymmetric external conical corners

A numerical study of the flowfield about asymmetrical external axial corners formed by the juncture of swept compressive wedges is presented. The geometrical configuration allows a unified treatment of external corners typical of delta wings and rectangular inlets. The study investigates how the flow transitions from a symmetrical flowfield with a cross-flow stagnation point at the corner to an asymmetrical flowfield for which the flow spills over the corner. The effects of leading-edge sweep, wedge compression, and corner radius are investigated.

Salas, M. D.↗

Two-dimensional turbulence models

Two-dimensional turbulence models are compared with experimental measurements made using an array of instrumented towers. The spatial correlation coefficient, the two-point spectrum or cross spectrum, and the coherence function are discussed. The prediction techniques in general agree reasonably well with the experimental results. Measurements of the integral length scale however, do not correlate well with the prediction model.

Frost, W.↗

An experimental trace gas investigation of fluid transport and mixing in a circular-to-rectangular transition duct

An ethylene trace gas technique was used to map out fluid transport and mixing within a circular to rectangular transition duct. Ethylene gas was injected at several points in a cross stream plane upstream of the transition duct. Ethylene concentration contours were determined at several cross stream measurement planes spaced axially within the duct. The flow involved a uniform inlet flow at a Mach number level of 0.5. Statistical analyses were used to quantitatively interpret the trace gas results. Also, trace gas data were considered along with aerodynamic and surface flow visualization results to ascertain transition duct flow phenomena. Convection of wall boundary layer fluid by vortices produced regions of high total pressure loss in the duct. The physical extent of these high loss regions is governed by turbulent diffusion.

Reichert, B. A.↗

An experimental trace gas investigation of fluid transport and mixing in a circular-to-rectangular transition duct

An ethylene trace gas technique was used to map out fluid transport and mixing within a circular-to-rectangular transition duct. Ethylene gas was injected at several points in a cross stream plane upstream of the transition duct. Ethylene concentration contours were determined at several cross stream measurement planes spaced axially within the duct. The flow involved a uniform inlet flow at a Mach number level of 0.5. Statistical analyses were used to quantitatively interpret the trace gas results. Also, trace gas data were considered along with aerodynamic and surface flow visualization results to ascertain transition duct flow phenomena. Convection of wall boundary layer fluid by vortices produced regions of high total pressure loss in the duct. The physical extent of these high loss regions is governed by turbulent diffusion.

Reichert, B. A.↗

Aerodynamic shape optimization of arbitrary hypersonic vehicles

A new method was developed to optimize, in terms of aerodynamic wave drag minimization, arbitrary (nonaxisymmetric) hypersonic vehicles in modified Newtonian flow, while maintaining the initial volume and length of the vehicle. This new method uses either a surface fitted Fourier series to represent the vehicle's geometry or an independent point motion algorithm. In either case, the coefficients of the Fourier series or the spatial locations of the points defining each cross section were varied and a numerical optimization algorithm based on a quasi-Newton gradient search concept was used to determine the new optimal configuration. Results indicate a significant decrease in aerodynamic wave drag for simple and complex geometries at relatively low CPU costs. In the case of a cone, the results agreed well with known analytical optimum ogive shapes. The procedure is capable of accepting more complex flow field analysis codes.

Dulikravich, George S.↗

The role of the molecular-metallic transition of hydrogen in the evolution of Jupiter, Saturn, and brown dwarfs

An equation of state for hydrogen which predicts a molecular-metallic phase transition at finite temperatures has become available recently. The effect of this phase transition on the cooling histories of these two giant planets and of substellar brown dwarfs is studied. The phase transition alters the present age of Jupiter and of Saturn by a few percent. Interestingly, the cooling of brown dwarfs is most strongly affected at the time when the interior adiabat crosses the critical point of the phase transition.

Saumon, Didier↗

CIIs During the May 98 CMEs

The Thermal Ion Dynamics Experiment (TIDE) instrument on the ISTP/Polar spacecraft observed intense Cusp Ion Injections (CIIs) during the May 1998 series of Coronal Mass Ejections (CMEs). The energy signatures of the CIIs can be used to determine the magnetic field topology of the geomagnetic field and the Interplanetary Magnetic Field (IMF) at the reconnection site. Particle tracing using model magnetic fields and the TIDE on observations are used to locate the point of magnetopause crossing.

Chandler, Michael O.↗