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At least 163 records · Page 9

The ATIC Long Duration Balloon Project

Long Duration Balloon (LDB) scientific experiments, launched to circumnavigate the south pole over Antarctica, have particular advantages compared to Shuttle or other Low Earth Orbit (LEO) missions in terms of cost, weight, scientific 'duty factor' and work force development. The Advanced Thin Ionization Calorimeter (ATIC) cosmic ray astrophysics experiment is a good example of a university-based project that takes full advantage of current LDB capability. The ATIC experiment is currently being prepared for its first LDB science flight that will investigate the charge composition and energy spectra of primary cosmic rays over the energy range from about 10(exp 10) to 10(exp 14) eV. The instrument is built around a fully active, Bismuth Germanate (BGO) ionization calorimeter to measure the energy deposited by the cascades formed by particles interacting in a thick carbon target. A highly segmented silicon matrix, located above the target, provides good incident charge resolution plus rejection of the 'backscattered' particles from the interaction. Trajectory reconstruction is based on the cascade profile in the BGO calorimeter, plus information from the three pairs of scintillator hodoscope layers in the target section above it. A full evaluation of the experiment was performed during a test flight occurring between 28 December 2000 and 13 January 2001 where ATIC was carried to an altitude of approx. 37 km above Antarctica by an approx. 850,000 cu m helium filled balloon for one circumnavigation of the continent. All systems behaved well, the detectors performed as expected, more than 43 gigabytes of engineering and cosmic ray event data was returned and these data are now undergoing preliminary data analysis. During the coming 2002-2003 Antarctica summer season, we are preparing for a ATIC science flight with approx. 15 to 30 days of continuous data collection in the near-space environment of LDB float altitudes.

Guzik, T. G.↗

Elevating Baseline Activation Does Not Facilitate Reading of Unattended Words

Previous studies have disagreed the extent to which people extract meaning from words presented outside the focus of spatial attention. The present study, examined a possible explanation for such discrepancies, inspired by attenuation theory: unattended words can be read more automatically when they have a high baseline level of activation (e.g., due to frequent repetition or due to being expected in a given context). We presented a brief prime word in lowercase, followed by a target word in uppercase. Participants indicated whether the target word belonged to a particular category (e.g., "sport"). When we drew attention to the prime word using a visual cue, the prime produced substantial priming effects on target responses (i.e., faster responses when the prime and target words were identical or from the same category than when they belonged to different categories). When prime words were not attended, however, they produced no priming effects. This finding replicated even when there were only 4 words, each repeated 160 times during the experiment. Even with a very high baseline level of activation, it appears that very little word processing is possible without spatial attention.

Mei-Ching Lien↗

Design and construction of a new detector to measure ultra-low radioactive-isotope contamination of argon

Large liquid argon detectors offer one of the best avenues for the detection of galactic weakly interacting massive particles (WIMPs) via their scattering on atomic nuclei. The liquid argon target allows exquisite discrimination between nuclear and electron recoil signals via pulse-shape discrimination of the scintillation signals. Atmospheric argon (AAr), however, has a naturally occurring radioactive isotope, 39Ar, a ß emitter of cosmogenic origin. For large detectors, the atmospheric 39Ar activity poses pile-up concerns. The use of argon extracted from underground wells, deprived of 39Ar, is key to the physics potential of these experiments. The DarkSide-20k dark matter search experiment will operate a dual-phase time projection chamber with 50 tonnes of radio-pure underground argon (UAr), that was shown to be depleted of 39Ar with respect to AAr by a factor larger than 1400. Assessing the 39Ar content of the UAr during extraction is crucial for the success of DarkSide-20k, as well as for future experiments of the Global Argon Dark Matter Collaboration (GADMC). This will be carried out by the DArT in ArDM experiment, a small chamber made with extremely radio-pure materials that will be placed at the centre of the ArDM detector, in the Canfranc Underground Laboratory (LSC) in Spain. The ArDM LAr volume acts as an active veto for background radioactivity, mostly ?-rays from the ArDM detector materials and the surrounding rock. This article describes the DArT in ArDM project, including the chamber design and construction, and reviews the background required to achieve the expected performance of the detector.

Noble liquid detectors, Dark Matter detectors, Cry↗

The Energy Spectra of Heavy Nuclei Measured by the ATIC Experiment

ATIC (Advanced Thin Ionization Calorimeter) is a balloon-borne experiment to measure the spectra and composition of primary cosmic rays in the region of total energy from 100 GeV to near 100 TeV for Z from 1 to 26. ATIC consists of a pixelated silicon matrix detector to measure charge plus a fully active BGO calorimeter, to measure energy, located below a carbon target interleaved with three layers of scintillator hodoscope. The ATIC instrument had a second (scientific) flight from McMurdo, Antarctica from 12/29/02 to 1/18/03, yielding 20 days of good data. The GEANT 3.21 Monte Carlo code with the QGSM event generator and the FLUKA code with the DPMJET-II event generator were used to convert energy deposition measurements to primary energy. We present the preliminary energy spectra for the abundant elements C, O, Ne, Mg, Si and Fe and compare them with the results of the first (test) flight of ATIC in 2000-01 and with results from the HEAO-3 and CRN experiments.

Panov, A. D.↗

Applying the ATOM drug discovery platform to small-molecule antivirals (Annual Report)

The objective of this project is to advance our understanding of the ML approaches needed to find the most potent inhibitor through an AI guided search that simultaneously optimizes for limited off-target safety activity and desirable pharmacokinetics (PK) properties. The methods will be tested for inhibiting SARS-CoV-2 activity through inhibition of the main protease as a demonstration, but the methodology will be developed to apply to any biothreat target using a small-molecule protein binding-based intervention, with limited experimental data. Computational experiments are conducted using our ATOM generative molecular design (GMD) loop software, which is the implementation of our AI/ML drug design pipeline.

59 BASIC BIOLOGICAL SCIENCES↗

Recent sounding rocket highlights and a concept for melding sounding rocket and space shuttle activities

Highlights include launching guided vehicles into the African Solar Eclipse, initiation of development of a Three-Stage Black Brant to explore the dayside polar cusp, large payload Aries Flights at White Sands Missile Range, and an active program with the Orion vehicle family using surplus motors. Sounding rocket philosophy and experience is being applied to the shuttle in a Get Away Special and Experiments of Opportunity Payloads Programs. In addition, an orbit selection and targeting software system to support shuttle pallet mounted experiments is under development.

Lane, J. H.↗

High Energy Cosmic Ray Electron Spectra measured from the ATIC Balloon Experiment

The Advanced Thin Ionization Calorimeter Balloon Experiment (ATIC) is specifically designed for high energy cosmic ray ion detection. From simulation and a CERN beam test exposure we find that the design consisting of a graphite target and an energy detection device, a totally active calorimeter of BGO scintillator, gives us sufficient information to distinguish electrons from protons up to the TeV energy range. Balloon observations were successfully carried out over Antarctica in both 2000/2001 and 2002/2003 for a total of more than 35 days. This paper presents preliminary results on the spectrum of high energy electrons observed in the first ATIC flight.

Chang, J.↗

Cross Section Measurements Using the Zero Degree Detector

The Zero Degree Detector (ZDD) is an instrument that has been used in accelerator exposures to measure the angular dependence of particles produced in heavy ion fragmentation experiments. The ZDD uses two identical layers of pixelated silicon detectors that make coincident measurements over the active area of the instrument. The angular distribution of secondary particle produced in nuclear interactions for several heavy ions: and target materials will be presented along with performance characteristic of the instrument.

Christl, M. J.↗

To See the Unseen: A History of Planetary Radar Astronomy

This book relates the history of planetary radar astronomy from its origins in radar to the present day and secondarily to bring to light that history as a case of 'Big Equipment but not Big Science'. Chapter One sketches the emergence of radar astronomy as an ongoing scientific activity at Jodrell Bank, where radar research revealed that meteors were part of the solar system. The chief Big Science driving early radar astronomy experiments was ionospheric research. Chapter Two links the Cold War and the Space Race to the first radar experiments attempted on planetary targets, while recounting the initial achievements of planetary radar, namely, the refinement of the astronomical unit and the rotational rate and direction of Venus. Chapter Three discusses early attempts to organize radar astronomy and the efforts at MIT's Lincoln Laboratory, in conjunction with Harvard radio astronomers, to acquire antenna time unfettered by military priorities. Here, the chief Big Science influencing the development of planetary radar astronomy was radio astronomy. Chapter Four spotlights the evolution of planetary radar astronomy at the Jet Propulsion Laboratory, a NASA facility, at Cornell University's Arecibo Observatory, and at Jodrell Bank. A congeries of funding from the military, the National Science Foundation, and finally NASA marked that evolution, which culminated in planetary radar astronomy finding a single Big Science patron, NASA. Chapter Five analyzes planetary radar astronomy as a science using the theoretical framework provided by philosopher of science Thomas Kuhn. Chapter Six explores the shift in planetary radar astronomy beginning in the 1970s that resulted from its financial and institutional relationship with NASA Big Science. Chapter Seven addresses the Magellan mission and its relation to the evolution of planetary radar astronomy from a ground-based to a space-based activity. Chapters Eight and Nine discuss the research carried out at ground-based facilities by this transformed planetary radar astronomy, as well as the upgrading of the Arecibo and Goldstone radars. A technical essay appended to this book provides an overview of planetary radar techniques, especially range-Doppler mapping.

Butrica, Andrew J.↗

ATIC Flight Data Processing

The first flight of the Advanced Thin Ionization Calorimeter (ATIC) experiment from McMurdo, Antarctica lasted for 16 days, starting in December, 2000. The ATIC instrument consists of a fully active 320-crystal, 960-channel Bismuth Germanate (BGO) calorimeter, 202 scintillator strips in 3 hodoscopes interleaved with a graphite target, and a 4480-pixel silicon matrix charge detector. We have developed an Object Oriented data processing package based on ROOT. In this paper, we will describe the data processing scheme used in handling the accumulated 45 GB of flight data. We will also discuss trigger issues by comparing the measured energy-dependent trigger efficiency with its simulation and calibration issues by considering the time-dependence of housekeeping information, etc.

Ahn, H. S.↗

Combustion, Complex Fluids, and Fluid Physics Experiments on the ISS

From the very early days of human spaceflight, NASA has been conducting experiments in space to understand the effect of weightlessness on physical and chemically reacting systems. NASA Glenn Research Center (GRC) in Cleveland, Ohio has been at the forefront of this research looking at both fundamental studies in microgravity as well as experiments targeted at reducing the risks to long duration human missions to the moon, Mars, and beyond. In the current International Space Station (ISS) era, we now have an orbiting laboratory that provides the highly desired condition of long-duration microgravity. This allows continuous and interactive research similar to Earth-based laboratories. Because of these capabilities, the ISS is an indispensible laboratory for low gravity research. NASA GRC has been actively involved in developing and operating facilities and experiments on the ISS since the beginning of a permanent human presence on November 2, 2000. As the lead Center for combustion, complex fluids, and fluid physics; GRC has led the successful implementation of the Combustion Integrated Rack (CIR) and the Fluids Integrated Rack (FIR) as well as the continued use of other facilities on the ISS. These facilities have supported combustion experiments in fundamental droplet combustion; fire detection; fire extinguishment; soot phenomena; flame liftoff and stability; and material flammability. The fluids experiments have studied capillary flow; magneto-rheological fluids; colloidal systems; extensional rheology; pool and nucleate boiling phenomena. In this paper, we provide an overview of the experiments conducted on the ISS over the past 12 years.

Motil, Brian↗

Combustion, Complex Fluids, and Fluid Physics Experiments on the ISS

From the very first days of human spaceflight, NASA has been conducting experiments in space to understand the effect of weightlessness on physical and chemically reacting systems. NASA Glenn Research Center (GRC) in Cleveland, Ohio has been at the forefront of this research looking at both fundamental studies in microgravity as well as experiments targeted at reducing the risks to long duration human missions to the moon, Mars, and beyond. In the current International Space Station (ISS) era, we now have an orbiting laboratory that provides the highly desired condition of long-duration microgravity. This allows continuous and interactive research similar to Earth-based laboratories. Because of these capabilities, the ISS is an indispensible laboratory for low gravity research. NASA GRC has been actively involved in developing and operating facilities and experiments on the ISS since the beginning of a permanent human presence on November 2, 2000. As the lead Center both Combustion, Fluid Physics, and Acceleration Measurement GRC has led the successful implementation of an Acceleration Measurement systems, the Combustion Integrated Rack (CIR), the Fluids Integrated Rack (FIR) as well as the continued use of other facilities on the ISS. These facilities have supported combustion experiments in fundamental droplet combustion fire detection fire extinguishment soot phenomena flame liftoff and stability and material flammability. The fluids experiments have studied capillary flow magneto-rheological fluids colloidal systems extensional rheology pool and nucleate boiling phenomena. In this paper, we provide an overview of the experiments conducted on the ISS over the past 12 years. We also provide a look to the future development. Experiments presented in combustion include areas such as droplet combustion, gaseous diffusion flames, solid fuels, premixed flame studies, fire safety, and super critical oxidation processes. In fluid physics, experiments are discussed in multiphase flows, capillary phenomena, and heat pipes. Finally in complex fluids, experiments in rheology and soft condensed materials will be presented.

Motil, Brian↗

Plans and Recent Developments for Fluid Physics Experiments Aboard the ISS

From the very first days of human spaceflight, NASA has been conducting experiments in space to understand the effect of weightlessness on physical and chemically reacting systems. NASA Glenn Research Center (GRC) in Cleveland, Ohio has been at the forefront of this research looking at both fundamental studies in microgravity as well as experiments targeted at reducing the risks to long duration human missions to the moon, Mars, and beyond. In the current International Space Station (ISS) era, we now have an orbiting laboratory that provides the highly desired condition of long-duration microgravity. This allows continuous and interactive research similar to Earth-based laboratories. Because of these capabilities, the ISS is an indispensable laboratory for low gravity research. NASA GRC has been actively involved in developing and operating facilities and experiments on the ISS since the beginning of a permanent human presence on November 2, 2000. As the lead Center for Fluid Physics, NASA GRC is developing and testing the Pack Bed Reactor Experiment (PBRE), Zero Boil Off (ZBOT) Two Phase Flow Separator Experiment (TPFSE), Multiphase Flow Heat Transfer (MFHT) Experiment and the Electro-HydroDynamic (EHD) experiment. An overview each experiment, including its objectives, concept and status will be presented. In addition, data will be made available after a nominal period to NASAs Physical Science Informatics PSI database to the scientific community to enable additional analyses of results.

Two phase flow↗

The XLZD Design Book: towards the next-generation liquid xenon observatory for dark matter and neutrino physics

This report describes the experimental strategy and technologies for XLZD, the next-generation xenon observatory sensitive to dark matter and neutrino physics. In the baseline design, the detector will have an active liquid xenon target of 60 tonnes, which could be increased to 80 tonnes if the market conditions for xenon are favorable. It is based on the mature liquid xenon time projection chamber technology used in current-generation experiments, LZ and XENONnT. The report discusses the baseline design and opportunities for further optimization of the individual detector components. The experiment envisaged here has the capability to explore parameter space for Weakly Interacting Massive Particle (WIMP) dark matter down to the neutrino fog, with a 3σ evidence potential for WIMP-nucleon cross sections as low as 3 x 10 –49 cm 2 (at 40 GeV/c 2 WIMP mass). The observatory will also have leading sensitivity to a wide range of alternative dark matter models. It is projected to have a 3σ observation potential of neutrinoless double beta decay of 136 Xe at a half-life of up to 5.7 x 10 27 years. Additionally, it is sensitive to astrophysical neutrinos from the sun and galactic supernovae.

72 PHYSICS OF ELEMENTARY PARTICLES AND FIELDS↗

Application of expert systems in project management decision aiding

The feasibility of developing an expert systems-based project management decision aid to enhance the performance of NASA project managers was assessed. The research effort included extensive literature reviews in the areas of project management, project management decision aiding, expert systems technology, and human-computer interface engineering. Literature reviews were augmented by focused interviews with NASA managers. Time estimation for project scheduling was identified as the target activity for decision augmentation, and a design was developed for an Integrated NASA System for Intelligent Time Estimation (INSITE). The proposed INSITE design was judged feasible with a low level of risk. A partial proof-of-concept experiment was performed and was successful. Specific conclusions drawn from the research and analyses are included. The INSITE concept is potentially applicable in any management sphere, commercial or government, where time estimation is required for project scheduling. As project scheduling is a nearly universal management activity, the range of possibilities is considerable. The INSITE concept also holds potential for enhancing other management tasks, especially in areas such as cost estimation, where estimation-by-analogy is already a proven method.

Harris, Regina↗

Visualization techniques to aid in the analysis of multi-spectral astrophysical data sets

This report describes our project activities for the period Sep. 1991 - Oct. 1992. Our activities included stabilizing the software system STAR, porting STAR to IDL/widgets (improved user interface), targeting new visualization techniques for multi-dimensional data visualization (emphasizing 3D visualization), and exploring leading-edge 3D interface devices. During the past project year we emphasized high-end visualization techniques, by exploring new tools offered by state-of-the-art visualization software (such as AVS3 and IDL4/widgets), by experimenting with tools still under research at the Department of Computer Science (e.g., use of glyphs for multidimensional data visualization), and by researching current 3D input/output devices as they could be used to explore 3D astrophysical data. As always, any project activity is driven by the need to interpret astrophysical data more effectively.

Domik, Gitta↗

ATIC Flight Data Processing

The first flight of the Advanced Thin Ionization Calorimeter (ATIC) experiment from McMurdo, Antarctica lasted for 16 days, starting on December 28, 2000. The ATIC instrument consists of a fully active 320-crystal, 960-channel Bismuth Germanate (BGO) calorimeter, 202 scintillator strips (808 channels) in 3 hodoscopes, interleaved with graphite target layers, and a 4480-pixel silicon matrix charge detector. We have developed an object-oriented data processing package based on ROOT. In this paper, we describe the data processing scheme used in handling the accumulated 45 GB of flight data. We discuss calibration issues, particularly the time-dependence of housekeeping information.

Ahn, H. S.↗

The Role of CDKN1a/p21 in Cellular Senescence of Bone Marrow Stem Cells Under Spaceflight Stressors

Spaceflight environments and their associated conditions, such as microgravity and space radiation, cause many biological functions formerly considered to be standard to behave in nonstandard ways. Exposure to microgravity has shown to induce deleterious effects in stem cell-based tissue regeneration, leading to immune system and healing response impairments as well as muscle and bone density loss. Such risks must be mitigated in order for long-term human space exploration to proceed. Thus, our work seeks to explore mechanisms of stem cell-based tissue regeneration that experience changes in spaceflight environments. Cellular senescence is a process of inducing cell cycle arrest that can be initiated by various stimuli. This function is influenced by two major pathways, controlled by p53 and pRB tumor suppressor proteins. p53 activity targets the cyclin-dependent kinase inhibitor gene p21Cdkn1a in osteogenic cell cycle arrest. Under conditions of mechanical unloading, stem cell-based tissue regeneration has shown to be decreased in both proliferation and differentiation, as many cells are arrested in progenitor states. p21 has shown upregulation in expression under conditions of microgravity, suggesting its role in regenerative bone formation arrest in space. p21 levels are found to be elevated independent of p53, suggesting a decrease in proliferation and regeneration without apoptosis, but rather through cell cycle arrest alone. Thus, we hypothesize that p21 is a mediator of cellular senescence in bone marrow stem cells. Culturing of bone marrow stem cells from wild type and p21 knockout mice under osteoblastogenic conditions will be completed to explore the role of p21Cdkn1a in stem cell proliferation and maturation. We believe that decreases in somatic stem cell differentiation may occur after spaceflight due to signal pathway alterations that result in downstream inhibition of genes involved in differentiation, preventing tissue from repairing and regenerating normally.

Stem Cells↗