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Search indexed NASA NTRS and DOE OSTI research on propulsion, heat transfer, battery materials and energy systems. Follow report and document links to the original sources.

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At least 1,603 records · Page 89
All sourcesNASA NTRSDOE OSTI
DOE OSTI2025

Future Circular Collider Feasibility Study Report

Volume 3 of the FCC Feasibility Report presents studies related to civil engineering, the development of a project implementation scenario, and environmental and sustainability aspects. The report details the iterative improvements made to the civil engineering concepts since 2018, taking into account subsurface conditions, accelerator and experiment requirements, and territorial considerations. It outlines a technically feasible and economically viable civil engineering configuration that serves as the baseline for detailed subsurface investigations, construction design, cost estimation, and project implementation planning. Additionally, the report highlights ongoing subsurface investigations in key areas to support the development of an improved 3D subsurface model of the region. The report describes the development of the project scenario based on the ‘avoid-reduce-compensate’ iterative optimisation approach. The reference scenario balances optimal physics performance with territorial compatibility, implementation risks, and costs. Environmental field investigations covering almost 600 hectares of terrain—including numerous urban, economic, social, and technical aspects—confirmed the project’s technical feasibility and contributed to the preparation of essential input documents for the formal project authorisation phase. The summary also highlights the initiation of public dialogue as part of the authorisation process. The results of a comprehensive socio-economic impact assessment, which included significant environmental effects, are presented. Even under the most conservative and stringent conditions, a positive benefit-cost ratio for the FCC-ee is obtained. Finally, the report provides a summary of the studies conducted to document the current state of the environment.

Benedikt, M. [European Organization for Nuclear Re↗
DOE OSTI2026

Zatom v1.0.0

Zatom is an AI foundation model for 3D molecules and materials.

Morehead, Alex [Lawrence Berkeley National Laborat↗
DOE OSTI2011

β1 integrin mediates an alternative survival pathway in breast cancer cells resistant to lapatinib

The overexpression of human epidermal growth factor receptor (HER)-2 in 20% of human breast cancers and its association with aggressive growth has led to widespread use of HER2-targeted therapies, such as trastuzumab (T) and lapatinib (L). Despite the success of these drugs, their efficacy is limited in patients whose tumors demonstrate de novo or acquired resistance to treatment. The b1 integrin resides on the membrane of the breast cancer cell, activating several elements of breast tumor progression including proliferation and survival. We developed a panel of HER2-overexpressing cell lines resistant to L, T, and the potent LT combination through long-term exposure and validated these models in 3D culture. Parental and L/T/LT-resistant cells were subject to HER2 and b1 integrin inhibitors in 3D and monitored for 12 days, followed by quantification of colony number. Parallel experiments were conducted where cells were either stained for Ki-67 and Terminal deoxynucleotidyl transferase dUTP nick end labeling (TUNEL) or harvested for protein and analyzed by immunoblot. Results were subjected to statistical testing using analysis of variance and linear contrasts, followed by adjustment with the Sidak method. Using multiple cell lines including BT474 and HCC1954, we reveal that in L and LT resistance, where phosphorylation of EGFR/HER1, HER2, and HER3 are strongly inhibited, kinases downstream of b1 integrin– including focal adhesion kinase (FAK) and Src–are up-regulated. Blockade of b1 by the antibody AIIB2 abrogates this up-regulation and functionally achieves significant growth inhibition of L and LT resistant cells in 3D, without dramatically affecting the parental cells. SiRNA against b1 as well as pharmacologic inhibition of FAK achieve the same growth inhibitory effect. In contrast, trastuzumab-resistant cells, which retain high levels of phosphorylated EGFR/HER1, HER2, and HER3, are only modestly growth-inhibited by AIIB2. Our data suggest that HER2 activity, which is suppressed in resistance involving L but not T alone, dictates whether b1 mediates an alternative pathway driving resistance. Our findings justify clinical studies investigating the inhibition of b1 or its downstream signaling moieties as strategies to overcome acquired L and LT resistance.

59 BASIC BIOLOGICAL SCIENCES↗
DOE OSTI2011

Stable Small Animal Mechanical Ventilation for Dynamic Lung Imaging to Support Computational Fluid Dynamics Models

Pulmonary computational fluid dynamics models require 3D images to be acquired over multiple points in the dynamic breathing cycle, with no breath holds or changes in ventilatory mechanics. With small animals, these requirements result in long imaging times ({approx}90 minutes), over which lung mechanics, such as compliance, can gradually change if not carefully monitored and controlled. These changes, caused by derecruitment of parenchymal tissue, are manifested as an upward drift in peak inspiratory pressure or by changes in the pressure waveform and/or lung volume over the course of the experiment. We demonstrate highly repeatable mechanical ventilation in anesthetized rats over a long duration for pulmonary CT imaging throughout the dynamic breathing cycle. We describe significant updates to a basic commercial ventilator that was acquired for these experiments. Key to achieving consistent results was the implementation of periodic deep breaths, or sighs, of extended duration to maintain lung recruitment. In addition, continuous monitoring of breath-to-breath pressure and volume waveforms and long-term trends in peak inspiratory pressure and flow provide diagnostics of changes in breathing mechanics.

59 BASIC BIOLOGICAL SCIENCES↗
DOE OSTI2013

Can Non-lytic CD8+ T Cells Drive HIV-1 Escape?

The CD8+ T cell effector mechanisms that mediate control of HIV-1 and SIV infections remain poorly understood. Recent work suggests that the mechanism may be primarily non-lytic. This is in apparent conflict with the observation that SIV and HIV-1 variants that escape CD8+ T cell surveillance are frequently selected. Whilst it is clear that a variant that has escaped a lytic response can have a fitness advantage compared to the wild-type, it is less obvious that this holds in the face of nonlytic control where both wild-type and variant infected cells would be affected by soluble factors. In particular, the high motility of T cells in lymphoid tissue would be expected to rapidly destroy local effects making selection of escape variants by non-lytic responses unlikely. The observation of frequent HIV-1 and SIV escape poses a number of questions. Most importantly, is the consistent observation of viral escape proof that HIV-1- and SIV-specific CD8+ T cells lyse infected cells or can this also be the result of non-lytic control? Additionally, the rate at which a variant strain escapes a lytic CD8+ T cell response is related to the strength of the response. Is the same relationship true for a non-lytic response? Finally, the potential anti-viral control mediated by non-lytic mechanisms compared to lytic mechanisms is unknown. These questions cannot be addressed with current experimental techniques nor with the standard mathematical models. Instead we have developed a 3D cellular automaton model of HIV-1 which captures spatial and temporal dynamics. The model reproduces in vivo HIV-1 dynamics at the cellular and population level. Using this model we demonstrate that non-lytic effector mechanisms can select for escape variants but that outgrowth of the variant is slower and less frequent than from a lytic response so that non-lytic responses can potentially offer more durable control.

59 BASIC BIOLOGICAL SCIENCES↗
DOE OSTI2018

Fallon FORGE: Seismic Reflection Profiles

Newly reprocessed Naval Air Station Fallon (1994) seismic lines: pre-stack depth migrations, with interpretations to support the Fallon FORGE (Phase 2B) 3D Geologic model. Data along seven profiles (>100 km of total profile length) through and adjacent to the Fallon site were re-processed. The most up-to-date, industry-tested seismic processing techniques were utilized to improve the signal strength and coherency in the sedimentary, volcanic, and Mesozoic crystalline basement sections, in conjunction with fault diffractions in order to improve the identification and definition of faults within the study area.

15 GEOTHERMAL ENERGY↗
DOE OSTI2023

EGS Collab Experiment 2: Shear Stimulation ERT Monitoring Data

This repository contains the electrical resistivity tomography (ERT) monitoring data that was collected before, during, and after shear stimulation attempts were conducted at EGS Collab. These tests were carried out on the SURF 4100 level during Experiment 2 in March, 2022. Flow and stimulation data corresponding to this dataset are available in a different GDR dataset, which is linked below. Also included here are the E4D input files that were used to process the ERT data. E4D is an open source ERT monitoring and inversion code which is linked for use below.

15 GEOTHERMAL ENERGY↗
DOE OSTI2022

Integrative illustration of a JCVI-syn3A minimal cell

Abstract Data from genomics, proteomics, structural biology and cryo-electron microscopy are integrated into a structural illustration of a cross section through an entire JCVI-syn3.0 minimal cell. The illustration is designed with several goals: to inspire excitement in science, to depict the underlying scientific results accurately, and to be feasible in traditional media. Design choices to achieve these goals include reduction of visual complexity with simplified representations, use of orthographic projection to retain scale relationships, and an approach to color that highlights functional compartments of the cell. Given that this simple cell provides an attractive laboratory for exploring the central processes needed for life, several functional narratives are included in the illustration, including division of the cell and the first depiction of an entire cellular proteome. The illustration lays the foundation for 3D molecular modeling of this cell.

Goodsell, David S.↗
DOE OSTI2012

The Effects of Low Dose Irradiation on Inflammatory Response Proteins in a 3D Reconstituted Human Skin Tissue Model

Skin responses to moderate and high doses of ionizing radiation include the induction of DNA repair, apoptosis, and stress response pathways. Additionally, numerous studies indicate that radiation exposure leads to inflammatory responses in skin cells and tissue. However, the inflammatory response of skin tissue to low dose radiation (<10 cGy) is poorly understood. In order to address this, we have utilized a reconstituted human skin tissue model (MatTek EpiDerm FT) and assessed changes in 23 cytokines twenty-four and forty eight hours following treatment of skin with either 3 or 10 cGy low-dose of radiation. Three cytokines, IFN-γ, IL-2, MIP-1α, were significantly altered in response to low dose radiation. In contrast, seven cytokines were significantly altered in response to a high radiation dose of 200 cGy (IL-2, IL-10, IL-13, IFN-γ, MIP-1α, TNF α, and VEGF) or the tumor promoter 12-O-tetradecanoylphorbol 13-acetate (G-CSF, GM-CSF, IL-1α, IL-8, MIP-1α, MIP-1β, RANTES). Additionally, radiation induced inflammation appears to have a distinct cytokine response relative to the non-radiation induced stressor, TPA. Overall, these results indicate that there are subtle changes in the inflammatory protein levels following exposure to low dose radiation and this response is a sub-set of what is seen following a high dose in a human skin tissue model.

Varnum, Susan M↗
DOE OSTI2025

AdditiveFOAM: A Continuum Multiphysics Code for Additive Manufacturing

AdditiveFOAM is a computational framework that simulates transport phenomena in Additive Manufacturing (AM) processes. It is built on OpenFOAM (Weller et al., 1998), the leading free, open-source software package for computational fluid dynamics (CFD). OpenFOAM offers an extensible platform for solving complex multiphysics problems using state-of-the-art finite volume methods. AdditiveFOAM leverages these capabilities to develop specialized tools aimed at addressing challenges in AM processing. Metal additive manufacturing, also known as metal 3D printing, is an advanced manufacturing technique that creates physical parts from a three-dimensional (3D) digital model by melting metal powder or wire feedstock. A significant area of research in metal AM focuses on process planning to mitigate anomalous features during printing that are deleterious to part performance (e.g., porosity and cracking), as well as controlling localized microstructure and material properties. Given the high costs and substantial time requirements associated with experimental methods for qualifying new materials and processes, there is a compelling incentive for researchers to utilize advanced computational simulations. In this context, AdditiveFOAM offers a simulation framework to better understand undesirable features in printing, thereby enhancing process planning and reducing the reliance on labor-intensive experimental campaigns.

Coleman, John [Oak Ridge National Laboratory (ORNL↗
DOE OSTI2013

Formation and Stability of Impurity "snakes" in Tokamak Plasmas

New observations of the formation and dynamics of long-lived impurity-induced helical "snake" modes in tokamak plasmas have recently been carried-out on Alcator C-Mod. The snakes form as an asymmetry in the impurity ion density that undergoes a seamless transition from a small helically displaced density to a large crescent-shaped helical structure inside q < 1, with a regularly sawtoothing core. The observations show that the conditions for the formation and persistence of a snake cannot be explained by plasma pressure alone. Instead, many features arise naturally from nonlinear interactions in a 3D MHD model that separately evolves the plasma density and temperature.

70 PLASMA PHYSICS AND FUSION TECHNOLOGY↗
DOE OSTI2014

Basin-Scale Leakage Risks from Geologic Carbon Sequestration: Impact on Carbon Capture and Storage Energy Market Competitiveness

This three-year project, performed by Princeton University in partnership with the University of Minnesota and Brookhaven National Laboratory, examined geologic carbon sequestration in regard to CO 2 leakage and potential subsurface liabilities. The research resulted in basin-scale analyses of CO 2 and brine leakage in light of uncertainties in the characteristics of leakage processes, and generated frameworks to monetize the risks of leakage interference with competing subsurface resources. The geographic focus was the Michigan sedimentary basin, for which a 3D topographical model was constructed to represent the hydrostratigraphy. Specifically for Ottawa County, a statistical analysis of the hydraulic properties of underlying sedimentary formations was conducted. For plausible scenarios of injection into the Mt. Simon sandstone, leakage rates were estimated and fluxes into shallow drinking-water aquifers were found to be less than natural analogs of CO 2 fluxes. We developed the Leakage Impact Valuation (LIV) model in which we identified stakeholders and estimated costs associated with leakage events. It was found that costs could be incurred even in the absence of legal action or other subsurface interference because there are substantial costs of finding and fixing the leak and from injection interruption. We developed a model framework called RISCS, which can be used to predict monetized risk of interference with subsurface resources by combining basin-scale leakage predictions with the LIV method. The project has also developed a cost calculator called the Economic and Policy Drivers Module (EPDM), which comprehensively calculates the costs of carbon sequestration and leakage, and can be used to examine major drivers for subsurface leakage liabilities in relation to specific injection scenarios and leakage events. Finally, we examined the competiveness of CCS in the energy market. This analysis, though qualitative, shows that financial incentives, such as a carbon tax, are needed for coal combustion with CCS to gain market share. In another part of the project we studied the role of geochemical reactions in affecting the probability of CO 2 leakage. A basin-scale simulation tool was modified to account for changes in leakage rates due to permeability alterations, based on simplified mathematical rules for the important geochemical reactions between acidified brines and caprock minerals. In studies of reactive flows in fractured caprocks, we examined the potential for permeability increases, and the extent to which existing reactive transport models would or would not be able to predict it. Using caprock specimens from the Eau Claire and Amherstburg, we found that substantial increases in permeability are possible for caprocks that have significant carbonate content, but minimal alteration is expected otherwise. We also found that while the permeability increase may be substantial, it is much less than what would be predicted from hydrodynamic models based on mechanical aperture alone because the roughness that is generated tends to inhibit flow.

54 ENVIRONMENTAL SCIENCES↗
DOE OSTI2014

Technical Report on the Status of Nonlinear Ultrasonic Techniques for Non-Destructive Inspection

This report summarizes technical work conducted by LANL staff and international collaborators in support of the UFD Storage Experimentation effort. The overall focus of this technical work is two-fold: a) on the detection and imaging of a failure mechanism known as stress corrosion cracking (SCC) in stainless steel, and b) on evaluating concrete degradation using nonlinear ultrasonic techniques. This year we report here on three research efforts: 1) experimental effort utilizing TREND and SPACE inspection techniques for crack detection in stainless steel; 2) numerical modeling of 3D time reversal focusing to quantify TREND inspection regions; and 3) application of nonlinear ultrasonic techniques for quantifying concrete degradation. The first and third were collaborative efforts. The first was performed in conjunction with the Tohoku University (Sendai, Japan) and CNRS Parametric Imaging Laboratory (Laboratoire d’Imagerie Parametrique, in Paris, France), with support from the Electricity of France (Électricité de France, [EDF], in Paris, France) project. The third research effort was performed in conjunction with the Federal Institute for Material Research and Testing (Bundesanstalt für Materialforschung und –prüfung, in Berlin, Germany) and The Pennsylvania State University (State College, PA). The conclusion to be made from these results is that nonlinear ultrasound is applicable as a spot inspection technique in both stainless steel and concrete, with the potential to be more broadly applied to other materials and environments. The nonlinear signature measured is related to the degree of damage/degradation. The localized nature of the measurement allows for identification of mechanical defects and localization of degraded regions. Further work is necessary to characterize the degradation (e.g., sensitivity, size of flaws, type of damage, residual strength, etc.). Additionally, for the SCC work to continue to progress, relevant samples must be acquired for study.

36 MATERIALS SCIENCE↗
DOE OSTI2015

Merging high resolution geophysical and geochemical surveys to reduce exploration risk at glass buttes, Oregon

The engineering and studies phase of the Glass Buttes project was aimed at reducing risk during the early stages of geothermal project development. The project’s inclusion of high resolution geophysical and geochemical surveys allowed Ormat to evaluate the value of these surveys both independently and in combination to quantify the most valuable course of action for exploration in an area where structure, permeability, and temperature are the most pressing questions. The sizes of the thermal anomalies at Glass Buttes are unusually large. Over the course of Phase I Ormat acquired high resolution LIDAR data to accurately map fault manifestations at the surface and collected detailed gravity and aeromagnetic surveys to map subsurface structural features. In addition, Ormat collected airborne hyperspectral data to assist with mapping the rock petrology and mineral alteration assemblages along Glass Buttes faults and magnetotelluric (MT) survey to try to better constrain the structures at depth. Direct and indirect identification of alteration assemblages reveal not only the geochemical character and temperature of the causative hydrothermal fluids but can also constrain areas of upflow along specific fault segments. All five datasets were merged along with subsurface lithologies and temperatures to predict the most likely locations for high permeability and hot fluids. The Glass Buttes temperature anomalies include 2 areas, totaling 60 km2 (23 mi2) of measured temperature gradients over 165° C/km (10° F/100ft). The Midnight Point temperature anomaly includes the Strat-1 well with 90°C (194 °F) at 603 m (1981 ft) with a 164 °C/km (10°F/100ft) temperature gradient at bottom hole and the GB-18 well with 71°C (160 °F) at 396 m (1300 ft) with a 182°C/km (11°F/100ft) gradient. The primary area of alteration and elevated temperature occurs near major fault intersections associated with Brothers Fault Zone and Basin and Range systems. Evidence for faulting is observed in each data set as follows. Field observations include fault plane orientations, complicated fault intersections, and hydrothermal alteration apparently pre-dating basalt flows. Geophysical anomalies include large, linear gradients in gravity and aeromagnetic data with magnetic lows possibly associated with alteration. Resistivity low anomalies also appear to have offsets associated with faulting. Hyperspectral and XRF identified alteration and individual volcanic flow units, respectively. When incorporated into a 3D geologic model, the fault intersections near the highest proven temperature and geophysical anomalies provide the first priority targets at Midnight Point. Ormat geologists selected the Midnight Point 52-33 drilling target based on a combination of pre-existing drilling data, geologic field work, geophysical interpretation, and geochemical analysis. Deep temperatures of well 52-33 was lower than anticipated. Temperature gradients in the well mirrored those found in historical drilling, but they decreased below 1500 ft and were isothermal below 2000 ft.

15 GEOTHERMAL ENERGY↗
DOE OSTI2017

Trends in Nuclear Explosion Monitoring Research & Development - A Physics Perspective

This document entitled “Trends in Nuclear Explosion Monitoring Research and Development – A Physics Perspective” reviews the accessible literature, as it relates to nuclear explosion monitoring and the Comprehensive Nuclear-Test-Ban Treaty (CTBT, 1996), for four research areas: source physics (understanding signal generation), signal propagation (accounting for changes through physical media), sensors (recording the signals), and signal analysis (processing the signal). Over 40 trends are addressed, such as moving from 1D to 3D earth models, from pick-based seismic event processing to full waveform processing, and from separate treatment of mechanical waves in different media to combined analyses. Highlighted in the document for each trend are the value and benefit to the monitoring mission, key papers that advanced the science, and promising research and development for the future.

46 INSTRUMENTATION RELATED TO NUCLEAR SCIENCE AND ↗
DOE OSTI2017

Advanced Analysis of Hydraulic Fracture Propagation and Efficiency Using Natural Gas as an Alternative to Water

Over the past years, new technologies have been presented as an alternative to minimize or eliminate the use of water in hydraulic fracturing for unconventional reservoirs, improve resource recovery, cost management and reduce environmental impact. As part of these technologies, energized fluids have been developed to mitigate the environmental impact caused by the application of large volumes of water during hydraulic fracturing. When a fracture is energized, the amount of water pumped during the fracturing process is reduced or eliminated by adding a gas component to the fracturing fluid. The less water that is pumped, the less damage it will create. A new technology called “Energized Natural Gas (ENG)” has recently been proposed for effective hydraulic fracturing in unconventional reservoirs. The ENG process shows that it may be a viable solution for the oil and gas industry. Due to the complexity of multiphase fluid behavior and fracture mechanics, further research and documentation is required to effectively apply gas and gas-water mixtures as a treatment fluid. The objective of this research is to further develop and demonstrate the use of natural gas as an optimum fracturing fluid for tight shale gas formations. GeoMechanics Technologies proposes to complete advanced analyses of hydraulic fracture propagation efficiency using natural gas as an alternative to water. A comprehensive review on the transport properties of gas and water mixtures was performed to investigate the rheology differences of conventionally-used fresh water and the natural gas mixture. This research helped to determine how rheology affects hydraulic fracturing. Then we developed a coupled 3D geomechanical model and fluid flow model to simulate hydraulic fracturing using various mixtures of natural gas and water to determine an effective combination. Gas production was also simulated to further test the effectiveness of the induced fracture. Finally, the technical and economic feasibility of this novel technology was considered and documented.

02 PETROLEUM↗
DOE OSTI2019

3D Particle-In-Cell Model of Axis-I: Cathode to Target Single-Code Development for Scorpius

Presentation summary: We are validating the Cathode-to-Target PIC model for Scorpius using Axis-I data and envelope codes. Results include particle transport and phase-space information. Future Work: Charge neutralization and ion focusing via target interactions, (example on next slide) investigation of misalignments of solenoid and accelerating gap fields, and investigation of chromatic effects due to pulsed power fluctuations. The bottom line is determining the impact on spot size.

43 PARTICLE ACCELERATORS↗