Managing the SOS Response for Enhanced CRISPR-Cas-Based Recombineering in E. coli through Transient Inhibition of Host RecA Activity
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Biochemistry & Molecular Biology↗
SEARCH · Engineering Papers
Results for “error rate”
Search indexed NASA NTRS and DOE OSTI research on propulsion, heat transfer, battery materials and energy systems. Follow report and document links to the original sources.
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Considerations for the modeling of the laser ablation region of ICF targets with Lagrangian simulations
Recently, much effort has been dedicated to the improvement of models and modeling choices utilized in radiation hydrodynamic simulations of direct drive inertial confinement fusion experiments in an effort to improve their predictive capability. In this paper, we consider the choice in mesh for the simulation of the laser ablation of a direct-drive-like target and compare Lagrangian simulations with various mesh zoning choices with Eulerian simulations with fixed resolution in the laser energy deposition region. Using these simulations, we demonstrate how errors in ablation pressure, laser deposition rate, shock speed, and density profile arise from insufficient zoning following from the conservation of mass of Lagrangian zones. These considerations place stringent requirements on the initial t = 0 zoning in the solid density shell for simulations aiming at resolving the ablation and laser absorption region. However, with sufficiently fine zoning in the t = 0 shell, agreement with Eulerian simulations and analytic scaling laws can be recovered.
70 PLASMA PHYSICS AND FUSION TECHNOLOGY↗
Dark Matter Search in a Proton Beam Dump with MiniBooNE
The MiniBooNE-DM Collaboration searched for vector-boson mediated production of dark matter using the Fermilab 8-GeV Booster proton beam in a dedicated run with 1.86 × 10 20 protons delivered to a steel beam dump. The MiniBooNE detector, 490 m downstream, is sensitive to dark matter via elastic scattering with nucleons in the detector mineral oil. Analysis methods developed for previous MiniBooNE scattering results were employed, and several constraining data sets were simultaneously analyzed to minimize systematic errors from neutrino flux and interaction rates. No excess of events over background was observed, leading to a 90% confidence limit on the dark matter cross section parameter, Y = ε 2 α D (m χ /m V ) 4 ≲10 –8 , for α D = 0.5 and for dark matter masses of 0.01 < m χ < 0.3 GeV in a vector portal model of dark matter. This is the best limit from a dedicated proton beam dump search in this mass and coupling range and extends below the mass range of direct dark matter searches. Here, these results demonstrate a novel and powerful approach to dark matter searches with beam dump experiments.
72 PHYSICS OF ELEMENTARY PARTICLES AND FIELDS↗
Towards Native Execution of Deep Learning on a Leadership-Class HPC System
Large parallel machines generally offer the best parallel performance with "native execution" that is achieved using codes developed with the optimized compilers, communication libraries, and runtimes offered on the machines. In this paper, we report and analyze performance results from native execution of deep learning on a leadership-class high-performance computing (HPC) system. Using our new code called DeepEx, we present a study of the parallel speed up and convergence rates of learning achieved with native parallel execution. In the trade-off between computational parallelism and synchronized convergence, we first focus on maximizing parallelism while still obtaining convergence. Scaling results are reported from execution on up to 15,000 GPUs using two scientific data sets from atom microscopy and protein folding applications, and also using the popular ImageNet data set. In terms of the traditional measure of parallel speed up, excellent scaling is observed up to 12,000 GPUs. Additionally, accounting for convergence rates of deep learning accuracy or error, a deep learning-specific metric called "learning speed up" is also tracked. The performance results indicate the need to evaluate parallel deep learning execution in terms of learning speed up, and point to additional directions for improved exploitation of high-end HPC systems.
Yoginath, Srikanth↗
SU-F-T-558: ArcCheck for Patient Specific QA in Stereotactic Ablative Radiotherapy
Purpose: Stereotactic Ablative Radiotherapy (SABR) is one of the most preferred treatment techniques for early stage lung cancer. This technique has been extended to other treatment sites like Spine, Liver, Scapula, Sternum etc., This has resulted in increased physics QA time on machine. In this study, we’ve tested the feasibility of using ArcCheck as an alternative method to replace film dosimetry. Methods: Twelve patients with varied diagnosis of Lung, Liver, scapula, sternum and Spine undergoing SABR were selected for this study. Pre-treatment QA was performed for all the patients which include ionization chamber and film dosimetry. The required gamma criteria for each SABR plan to pass QA and proceed to treatment is 95% (3%,1mm). In addition to this routine process, the treatment plans were exported on to an ArcCheck phantom. The planned and measured dose from the ArcCheck device were compared using four different gamma criteria: 2%,2 mm, 3%,2 mm, 3%,1 mm and 3%, 3 mm. In addition to this, we’ve also introduced errors to gantry, collimator and couch angle to assess sensitivity of the ArcCheck with potential delivery errors. Results: The ArcCheck mean passing rates for all twelve cases were 76.1%±9.7% for gamma criteria 3%,1 mm, 89.5%±5.3% for 2%,2 mm, 92.6%±4.2% for 3%,2 mm, and 97.6%±2.4% for 3%,3 mm gamma criteria. When SABR spine cases are excluded, we observe ArcCheck passing rates higher than 95% for all the studied cases with 3%, 3mm, and ArcCheck results in acceptable agreement with the film gamma results. Conclusion: Our ArcCheck results at 3%, 3 mm were found to correlate well with our non-SABR spine routine patient specific QA results (3%,1 mm). We observed significant reduction in QA time on using ArcCheck for SABR QA. This study shows that ArcCheck could replace film dosimetry for all sites except SABR spine.
60 APPLIED LIFE SCIENCES↗
Generating moment matching scenarios using optimization techniques
An optimization based method is proposed to generate moment matching scenarios for numerical integration and its use in stochastic programming. The main advantage of the method is its flexibility: it can generate scenarios matching any prescribed set of moments of the underlying distribution rather than matching all moments up to a certain order, and the distribution can be defined over an arbitrary set. This allows for a reduction in the number of scenarios and allows the scenarios to be better tailored to the problem at hand. The method is based on a semi-infinite linear programming formulation of the problem that is shown to be solvable with polynomial iteration complexity. A practical column generation method is implemented. The column generation subproblems are polynomial optimization problems; however, they need not be solved to optimality. It is found that the columns in the column generation approach can be efficiently generated by random sampling. The number of scenarios generated matches a lower bound of Tchakaloff's. The rate of convergence of the approximation error is established for continuous integrands, and an improved bound is given for smooth integrands. Extensive numerical experiments are presented in which variants of the proposed method are compared to Monte Carlo and quasi-Monte Carlo methods on both numerical integration problems and stochastic optimization problems. The benefits of being able to match any prescribed set of moments, rather than all moments up to a certain order, is also demonstrated using optimization problems with 100-dimensional random vectors. Here, empirical results show that the proposed approach outperforms Monte Carlo and quasi-Monte Carlo based approaches on the tested problems.
97 MATHEMATICS AND COMPUTING↗
Improving Solution Accuracy and Convergence for Stochastic Physics Parameterizations with Colored Noise
Stochastic parameterizations are used in numerical weather prediction and climate modeling to help capture the uncertainty in the simulations and improve their statistical properties. Convergence issues can arise when time integration methods originally developed for deterministic differential equations are applied naively to stochastic problems. In previous studies, it has been demonstrated that a correction term, known in stochastic analysis as the Itô correction, can help improve solution accuracy for various deterministic numerical schemes and ensure convergence to the physically relevant solution without substantial computational overhead. The usual formulation of the Itô correction is valid only when the stochasticity is represented by white noise. In this study, a generalized formulation of the Itô correction is derived for noises of any color. The formulation is applied to a test problem described by an advection–diffusion equation forced with a spectrum of fast processes. We present numerical results for cases with both constant and spatially varying advection velocities to show that, for the same time step sizes, the introduction of the generalized Itô correction helps to substantially reduce time integration error and significantly improve the convergence rate of the numerical solutions when the forcing term in the governing equation is rough (fast varying); alternatively, for the same target accuracy, the generalized Itô correction allows for the use of significantly longer time steps and, hence, helps to reduce the computational cost of the numerical simulation.
54 ENVIRONMENTAL SCIENCES↗
Sensitivity of resonance properties of all-dielectric multilayers driven by statistical fluctuations
In photonics and emerging fields of quantum and topological materials, increasing demands are placed upon the state and control of electromagnetic fields. Dielectric multilayer materials may be designed and optimized to possess extremely sharp spectral and angular photonic resonances allowing for the creation of fields orders of magnitude larger than the exciting field. With enhancements of 10 4 and higher, the extreme nature of these resonances places high constraints on the statistical properties of the physical and optical characteristics of the materials. To what extent the spectral and angular shifts occur as a result of fluctuations in the refractive indices and morphologies of the involved low-loss subdomains have not been considered previously. Here, we present how parameter variations such as those caused by fluctuations in deposition rate, yielding bias, random and compensated errors, may affect the resonance properties of low-loss all-dielectric stacks.
71 CLASSICAL AND QUANTUM MECHANICS, GENERAL PHYSIC↗
Verification & Validation of High-Order Short-Characteristics-Based Deterministic Transport Methodology on Unstructured Grids
The research team has developed a practical, high-order, discrete-ordinates, short characteristics neutron transport code for three-dimensional configurations represented on unstructured tetrahedral grids that can be used for realistic reactor physics applications at both the assembly and core levels. This project will perform a comprehensive verification and validation of this new computational tool against both a continuous-energy Monte Carlo simulation (e.g. MCNP) and experimentally measured data, an essential prerequisite for its deployment in reactor core modeling. Verification is divided into three phases. The team will first conduct spatial mesh and expansion order refinement studies to monitor convergence of the numerical solution to reference solutions. This is quantified by convergence rates that are based on integral error norms computed from the cell-by-cell difference between the code’s numerical solution and its reference counterpart. The latter is either analytic or very fine- mesh numerical solutions from independent computational tools. For the second phase, the team will create a suite of code-independent benchmark configurations to enable testing the theoretical order of accuracy of any particular discretization of the discrete ordinates approximation of the transport equation. For each tested case (i.e. mesh and spatial approximation order), researchers will execute the code and compare the resulting numerical solution to the exact solution on a per cell basis to determine the distribution of the numerical error. The final activity comprises a comparison to continuous-energy Monte Carlo solutions for zero-power critical configuration measurements at Idaho National Laboratory’s Advanced Test Reactor (ATR). Results of this comparison will allow the investigators to distinguish between modeling errors and the above-listed discretization errors introduced by the deterministic method, and to separate the sources of uncertainty.
22 GENERAL STUDIES OF NUCLEAR REACTORS↗
Benchmark Analysis of the HTR-10 with the MAMMOTH Reactor Physics Application
This report documents a set of benchmarks used to validate the Serpent and MAMMOTH neutron transport models of the HTR-10 reactor developed at Idaho National Laboratory. The high-fidelity Serpent Monte Carlo models of the HTR-10 critical and full core configurations include both random, discrete distributions of TRISO particles in the pebbles and random, discrete pebble distributions in the pebble bed core. The Serpent results agree very well with the critical and control rod worth measurements provided in the International Re- actor Physics Experiment Evaluation Project (IRPhEP) report if the ENDF/B-VII.r1 data- set is used. These Serpent models are subsequently used to prepare cross sections and flux tallies in a 10 coarse energy group structure for the MAMMOTH Reactor Physics MOOSE- based application. We find that MAMMOTH can reproduce the Monte Carlo solution for the HTR-10 reactor by using the PJFNK-SPH equivalence method. In all cases studied, the MAMMOTH results are within 120 pcm of the Monte Carlo reference calculation and the maximum errors in neutron absorption and generation rates are within 0.536% and 0.215% from the reference calculation, respectively. A set of benchmark exercises from the International Atomic Energy Agency (IAEA) HTR-10 benchmark in IAEA-TECDOC-1382 were conducted including parts B1 (critical), B2 (temperature coefficient) and B3 (control rod worth). The results we obtain for the critical core are in excellent agreement with the expected value and we confirm that with ENDF/B-VII.r1 data we match the critical eigen- value keff=1 to within 100 pcm. Our temperature coefficient calculation is consistent with the VSOP results generated by the German participants. The Chinese and South African VSOP models produce lower temperature coefficients, a fact that was noted in the original IAEA benchmark, but for which no explanation was provided. Both a full and single control rod worth calculations with Serpent and MAMMOTH agree well with the results from the IAEA benchmark. Finally, and most importantly, this work demonstrates that MAM- MOTH can recover the Monte Carlo high-fidelity solutions to an excellent accuracy using the PJFNK-SPH method. This sets the stage for the ultimate goal of using MAMMOTH in transient, multi-physics scenarios where correction of the cross sections is obtained for steady-state conditions and then used in the transient scenario for which no Monte-Carlo solution is available.
22 GENERAL STUDIES OF NUCLEAR REACTORS↗
Product Consistency Test and Vapor Hydration Test Comparisons of a Radioactive Hanford Waste Glass with its Non-Radioactive Simulant Glass
Product Consistency Tests (PCT) and Vapor Hydration Tests (VHT) were performed on a radioactive glass made from Hanford tank AP-107 waste (i.e., R-AP-107) and its non-radioactive equivalent glass made from simulated tank waste (i.e., S-AP-107). The radioactive and non-radioactive experiments were conducted in parallel with identical equipment, protocols, and staff to remove additional experimental uncertainties. PCT and VHT results are reported for all samples and are shown in Table S.1. Average normalized mass loss of B ( NL B ) and Na ( NL Na ) calculated from the three replicate test results for each glass with their respective standard deviations (SD) are presented for PCT results while individual VHT rates ( r VHT ) with their propagated errors ( σ r prop ) from individual thickness measurements on each sample are presented for the VHT results. Some VHT samples experienced more than 50% evaporation loss during the experiments. However, no visible alteration was detected on any VHT samples regardless on the amount of evaporation loss detected as shown in Table S.1.
12 MANAGEMENT OF RADIOACTIVE AND NON-RADIOACTIVE W↗
Cryogenic Platforms at Fermilab: Recent Results and Outlook
The Cosmic Quantum group at Fermilab operates three cryogenic facilities dedicated to the development and calibration of superconducting low-threshold detectors and qubits. One of which (LOUD) is located at the surface, while the other two (NEXUS and QUIET) are located 100 m underground enabling low-background device characterization and rare event searches. Recently, we have demonstrated world-leading resolution in the quasiparticle channel for kinetic inductance phonon-mediated detectors as well as the lowest rate of spatially- and temporally- correlated errors ( charge jumps ) in superconducting qubit chips. We have additionally made significant progress in expanding the suite of tools for simulating signal production and readout of these devices. In this talk, I will review these recent results, discuss some nascent projects focused on enhancing sensitivity of these detectors to sub-GeV dark matter, and highlight activities in these facilities over the next year.
Temples, Dylan J.↗
A comparison of optimum angle modulation systems and rate-distortion bounds.
Analog message transmission by optimum angle modulation system and rate distortion function deriving mean square error
MODULATION TECHNIQUE↗
Block encoders for Reed-Muller codes
Encoding algorithms generate a 32 x 64-bit matrix Reed-Muller code from a 6-bit orthogonal code-word. This increases error-free reception by a high rate telemetry channel under adverse signal noise with minimal use of additional hardware.
Anderson, T. O.↗
Rate distortion function for a Gaussian source model of images
Gaussian source model of image, deriving rate distortion function under mean square error criterion
Habibi, A.↗
Error evaluation for difference approximations to ordinary differential equations
Method involves relationships between errors introduced by using finite sampling rates and parameters describing specific numerical method used. Procedurre is used in design and analysi of digital filters and simulators.
Hammond, J. L., Jr.↗
Some long, rate one-half, binary convolutional codes with an optimum distance profile and the systematic versus nonsystematic code question
A tabulation is given of long systematic and long quick-look-in (QLI) nonsystematic rate R = 1/2 binary convolutional codes with an optimum distance profile (ODP). These codes appear attractive for use with sequential decoders. Simulations for two of the new codes are reported and confirm Massey's conjecture that systematic and non-systematic codes of the same rate yield nearly identical computational and error probability performance with sequential decoding when the number of digits transmitted in the tail of the encoded frame is the same for both codes.
Johannesson, R.↗
Study to investigate and evaluate means of optimizing the Ku-band combined radar/communication functions for the space shuttle
The performance of the space shuttle orbiter's Ku-Band integrated radar and communications equipment is analyzed for the radar mode of operation. The block diagram of the rendezvous radar subsystem is described. Power budgets for passive target detection are calculated, based on the estimated values of system losses. Requirements for processing of radar signals in the search and track modes are examined. Time multiplexed, single-channel, angle tracking of passive scintillating targets is analyzed. Radar performance in the presence of main lobe ground clutter is considered and candidate techniques for clutter suppression are discussed. Principal system parameter drivers are examined for the case of stationkeeping at ranges comparable to target dimension. Candidate ranging waveforms for short range operation are analyzed and compared. The logarithmic error discriminant utilized for range, range rate and angle tracking is formulated and applied to the quantitative analysis of radar subsystem tracking loops.
Weber, C. L.↗