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At least 1,585 records · Page 88
All sourcesNASA NTRSDOE OSTI
DOE OSTI2023

Status and future plans for C 3 R&D

C 3 is an opportunity to realize an e + e - collider for the study of the Higgs boson at √s = 250 GeV, with a well defined upgrade path to 550 GeV while staying on the same short facility footprint. C 3 is based on a fundamentally new approach to normal conducting linear accelerators that achieves both high gradient and high efficiency at relatively low cost. Given the advanced state of linear collider designs, the key system that requires technical maturation for C 3 is the main linac. This paper presents the staged approach towards a facility to demonstrate C 3 technology with both Direct (source and main linac) and Parallel (beam delivery, damping ring, ancillary component) R&D. The primary goal of the C 3 Demonstration R&D Plan is to reduce technical and cost risk by building and operating the key components of C 3 at an adequate scale. This R&D plan starts with the engineering design, and demonstration of one cryomodule and will culminate in the construction of a 3 cryomodule linac with pre-production prototypes. This R&D program would also demonstrate the linac rf fundamentals including achievable gradient and gradient stability over a full electron bunch train and breakdown rates. It will also investigate beam dynamics including energy spread, wakefields, and emittance growth. This work will be critical to confirm the suitability of the C 3 beam parameters for the physics reach and detector performance in preparation for a Conceptual Design Report (CDR), as well as for follow-on technology development and industrialization. The C 3 Demonstration R&D Plan will open up significant new scientific and technical opportunities based on development of high-gradient and high-efficiency accelerator technology. It will push this technology to operate both at the GeV scale and mature the technology to be reliable and provide high-brightness electron beams. The timeline for progressing with C 3 technology development will be governed by practical limitations on both the technical progress and resource availability. It consists of four stages: Stage 0) Ongoing fundamental R&D on structure prototypes, damping and vibrations. Stage 1) Advancing the engineering maturity of the design and developing start-to-end simulations including space-charge and wakefield effects. This stage will include testing of strucutres operating at cryogenic temperatures. Beam tests would be performed with high beam current to test full beam loading. Stage 2) Production and testing of the first cryomodule at cryogenic temperatures. This would provide sufficient experimental data to compile a CDR and it is anticipated for Stage 2 to last 3 years and to culminate with the transport of photo-electrons through the first cryomodule. Stage 3) Updates to the engineering design of the cryomodules, production of the second and third cryomodule and their installation. Lower charge and lower emittance beams will be used to investigate emittance growth. The successful full demonstration of the 3 cryomodules to deliver up to a 3 GeV beam and achieve the C 3 five gradient will allow a comprehensive and robust evaluation of the technical design of C 3 as well as mitigate technical, schedule, and cost risks required to proceed with a Technical Design Report (TDR).

radiation hardened magnets↗
DOE OSTI2024

Status and perspectives of the ICARUS experiment at the Fermilab Short Baseline Neutrino program

In this study, the ICARUS collaboration has employed the 760 t T600 detector in a successful three-year physics run at the underground LNGS laboratory, performing a sensitive search for LSND-like anomalous ν e appearance in the CERN Neutrino to Gran Sasso beam, which contributed to the constraints on the allowed neutrino oscillation parameters to a narrow region around Δm 2 ~ 1 eV 2 . After a significant overhaul at CERN, the T600 detector has been installed at Fermilab. In 2020 the cryogenic commissioning began with detector cool down, liquid Argon filling and recirculation. ICARUS then started its operation collecting the first neutrino events from the Booster Neutrino Beam (BNB) and the Neutrinos at the Main Injector (NuMI) beam off-axis, which were used to test the ICARUS event selection, reconstruction and analysis algorithms. ICARUS successfully completed its commissioning phase in June 2022, moving then to data taking for neutrino oscillation physics, aiming at first to either confirm or refute the claim by Neutrino-4 short-baseline reactor. ICARUS will also jointly search for evidence of sterile neutrinos together with the Short-Baseline Near Detector, within the Fermilab Short-Baseline Neutrino program experiment, and will perform measurements of neutrino cross sections with both beams and several Beyond Standard Model searches with the NuMI beam. In this paper, the main technical achievements of the ICARUS detector subsystems (Time Projection Chambers, Light Detection System, Cosmic Ray Tagger, Trigger and Data Acquisition) obtained with both BNB and NuMI neutrino beams during the commissioning phase, will be presented in terms of the overall detector performance and capability to select and reconstruct neutrino events.

46 INSTRUMENTATION RELATED TO NUCLEAR SCIENCE AND ↗
DOE OSTI2022

Status of the PIP-II Cryoplant

The Proton Improvement Plan-II (PIP-II) is an essential upgrade to the Fermilab accelerator complex featuring a new 800-MeV Superconducting Radio-Frequency (SRF) linear accelerator (Linac). The Linac contains 23 SRF cryomodules with the SRF cavities operating at 2 K, a high temperature thermal shield at 40 K and low temperature intercepts at 4.5 K. The PIP-II cryoplant will provide the necessary cooling for the cryomodules and the cryogenic distribution system interconnecting cryoplant and cryomodules. This paper describes the evolution of the PIP-II cryoplant conceptual design and specifications, including the expected heat loads, required cooling features and the integrated design. The cryoplant capacity margin analysis and fast cool-down mode will also be discussed.

43 PARTICLE ACCELERATORS↗
DOE OSTI2020

Status of the LCLS-II Cryogenic Distribution System

The LINAC Coherent Light Source II (LCLS-II) located at SLAC National Accelerator Laboratory (SLAC) in Menlo Park, CA, is a U.S. Department of Energy project tasked to design and build a world-class x-ray free-electron laser facility for scientific research. The Linac has superconducting radio frequency cryomodules that are connected to the cryogenic plant by the Cryogenic Distribution System (CDS), which consists of distribution boxes with heat exchangers and reliefs, feed caps, end caps, and surface, vertical, and bypass transfer lines. The CDS components were designed and built to specification by industry. The components have been delivered and their installation at SLAC will be discussed. The as-built relief system design will be presented, showing minimization of relief inlet pressure drops while meeting capacity requirements. The relieving flow pressure drops along the lengths of the CDS to centrally located reliefs at the distribution box were analysed to satisfy Pressure Vessel and Process Piping Code criteria to ensure relief performance. The sub-atmospheric 2 K circuit relieving approach will be discussed, which includes a three-way diverter isolation valve suitable for sub-atmospheric service. The component anchoring load design approach and installation into concrete floor will be discussed. This addresses loading, including seismic loading, along the component’s load path to floor anchoring system.

43 PARTICLE ACCELERATORS↗
DOE OSTI2019

Elevated plasma triglycerides and growth rate are early indicators of reproductive status in post-spawning female steelhead trout (Oncorhynchus mykiss)

Abstract Many iteroparous fishes spawn after skipping one or more yearly cycles, which impacts recruitment estimates used for fisheries management and conservation. The physiological mechanisms underlying the development of consecutive and skip spawning life histories in fishes are not well understood. In salmonids, lipid energy reserves and/or growth are thought to regulate the initiation of reproductive maturation during a critical period ~1 year prior to spawning. The fasting spawning migration of summer-run steelhead trout (Oncorhynchus mykiss) results in significant depletion of energy reserves during the proposed critical period for repeat spawning. To determine whether and when lipid energy reserves and growth influence repeat spawning, measures of lipid energy reserves, growth rate and reproductive development were tracked in female steelhead trout from first to second spawning as a consecutive or skip spawner in captivity. Plasma triglyceride (TG) levels and growth rate were elevated by 10 weeks after spawning in reproductive (i.e. consecutive spawning) versus non-reproductive (i.e. skip spawning) individuals. Muscle lipid (ML) levels, condition factor and plasma estradiol levels increased at later time points. The early differences in plasma TG levels and increases in growth rate are attributable to differential rates of feeding and assimilation between the groups following spawning. A year after spawning, plasma TG levels, MLs and growth rate decreased in consecutive spawners, attributable to transfer of lipid reserves into the ovary. During the year prior to second spawning, energy reserves and plasma estradiol levels were higher in reproductive skip spawners versus consecutive spawners, reflecting the energy deficit after first spawning. These results suggest that the decision to initiate ovarian recrudescence occurs by 10 weeks after first spawning and are consistent with the differences in energy reserves acquired following spawning being a consequence of that decision. This information will increase the success of conservation projects reconditioning post-spawning summer-run steelhead trout.

Jenkins, Laura E.↗
DOE OSTI2016

Distinctive Klf4 mutants determine preference for DNA methylation status

Reprogramming of mammalian genome methylation is critically important but poorly understood. Klf4, a transcription factor directing reprogramming, contains a DNA binding domain with three consecutive C2H2 zinc fingers. Klf4 recognizes CpG or TpG within a specific sequence. Mouse Klf4 DNA binding domain has roughly equal affinity for methylated CpG or TpG, and slightly lower affinity for unmodified CpG. The structural basis for this key preference is unclear, though the side chain of Glu446 is known to contact the methyl group of 5-methylcytosine (5mC) or thymine (5-methyluracil). We examined the role of Glu446 by mutagenesis. Substituting Glu446 with aspartate (E446D) resulted in preference for unmodified cytosine, due to decreased affinity for 5mC. In contrast, substituting Glu446 with proline (E446P) increased affinity for 5mC by two orders of magnitude. Structural analysis revealed hydrophobic interaction between the proline's aliphatic cyclic structure and the 5-methyl group of the pyrimidine (5mC or T). As in wild-type Klf4 (E446), the proline at position 446 does not interact directly with either the 5mC N4 nitrogen or the thymine O4 oxygen. In contrast, the unmethylated cytosine's exocyclic N4 amino group (NH2) and its ring carbon C5 atom hydrogen bond directly with the aspartate carboxylate of the E446D variant. Both of these interactions would provide a preference for cytosine over thymine, and the latter one could explain the E446D preference for unmethylated cytosine. Finally, we evaluated the ability of these Klf4 mutants to regulate transcription of methylated and unmethylated promoters in a luciferase reporter assay.

59 BASIC BIOLOGICAL SCIENCES↗
DOE OSTI2022

Rubisco regulation in response to altered carbon status in the cyanobacterium Synechococcus elongatus PCC 7942

Abstract Photosynthetic organisms possess a variety of mechanisms to achieve balance between absorbed light (source) and the capacity to metabolically utilize or dissipate this energy (sink). While regulatory processes that detect changes in metabolic status/balance are relatively well studied in plants, analogous pathways remain poorly characterized in photosynthetic microbes. Here, we explored systemic changes that result from alterations in carbon availability in the model cyanobacterium Synechococcus elongatus PCC 7942 by taking advantage of an engineered strain where influx/efflux of a central carbon metabolite, sucrose, can be regulated experimentally. We observed that induction of a high-flux sucrose export pathway leads to depletion of internal carbon storage pools (glycogen) and concurrent increases in estimates of photosynthetic activity. Further, a proteome-wide analysis and fluorescence reporter-based analysis revealed that upregulated factors following the activation of the metabolic sink are concentrated on ribulose-1,5-bisphosphate carboxylase-oxygenase (Rubisco) and auxiliary modules involved in Rubisco maturation. Carboxysome number and Rubisco activity also increased following engagement of sucrose secretion. Conversely, reversing the flux of sucrose by feeding exogenous sucrose through the heterologous transporter resulted in increased glycogen pools, decreased Rubisco abundance, and carboxysome reorganization. Our data suggest that Rubisco activity and organization are key variables connected to regulatory pathways involved in metabolic balancing in cyanobacteria.

Plant Sciences↗
DOE OSTI2024

Endophyte mediated Populus trichocarpa water use efficiency is dependent on time of day and plant water status

Endophytes are potential partners for improving the resource use efficiency of bioenergy feedstock systems such as short rotation coppiced Populus. Endophytes isolated from members of the Salicaceae family have broad host compatibility and can improve water use efficiency (WUE) through decreases in stomatal conductance. However, the literature is inconsistent with regards to the environmental conditions and temporal patterns of these benefits. This study investigates how endophyte mediated changes in Populus trichocarpa (Torr. and Gray) ‘Nisqually-1’ stomatal conductance and WUE shift with time and scale in response to water-deficit stress. Leaf gas exchange and above-ground productivity were used to evaluate the carbon and water balances of glasshouse grown plants in response to endophyte inoculation and water-deficit. Differences in stomatal conductance between control and inoculated plants were more pronounced (39.7 % decrease, Welch’s two-sample t(14.34 dfadj) = -2.358, p-value = 0.033) under water-deficit conditions in the late morning during a period of higher light intensity. The decrease in stomatal conductance accompanied a substantial increase in intrinsic WUE (iWUE) for water-deficit inoculated plants. However, increases in iWUE did not result in improvements in aboveground productivity or shoot biomass WUE (WUEsb) for water-deficit inoculated plants. This decoupling between iWUE and aboveground productivity may be an indicator of assimilate allocation to microbial metabolism as an additional carbon sink or a shift in carbon allocation towards belowground biomass. Future work should take a whole-plant approach that accounts for diurnal patterns in incident irradiance to evaluate the impact of endophyte inoculation on host WUE and stress tolerance.

59 BASIC BIOLOGICAL SCIENCES↗
DOE OSTI2019

Status of free-energy representations for the homogeneous electron gas

Renewed interest in the homogeneous electron gas (HEG) has been stimulated by recent accurate simulations of it over a wide range of densities and temperatures. Those data, combined with known theoretical limits, have led to analytical representations of the free energy. Such a representation is, at least in principle, the complete HEG equation of state. The initial objective here is to establish that the two best representations of the simulation data and constraints are effectively the same in both functional form and accuracy of representation. The second objective is to disclose and delineate a significant difficulty. Despite their expected accuracy for the free energy, the underlying functional form is not adequate for derived thermodynamic properties. As an example, the specific heats obtained from the representations exhibit anomalies suggesting the need first for additional simulation data in critical regimes, then for refined fitting functions. Here, the existing representations are, however, almost certainly adequate for applications based on the free energy alone (e.g., density functional theory for warm dense matter). The third objective is to show that, despite their inability to provide a complete thermodynamic description of the HEG, the best analytical representations do provide a fully adequate exchange-correlation local density approximation for free energy density functional calculations.

75 CONDENSED MATTER PHYSICS, SUPERCONDUCTIVITY AND↗
DOE OSTI2025

Current status of the light neutralino thermal dark matter in the phenomenological MSSM

In a previous publication, we studied the parameter space of the phenomenological minimal Supersymmetric standard model with a light neutralino thermal dark matter ( M χ ˜ 1 0 ≤ M h / 2 ) and observed that the recent results from the dark matter and collider experiments put strong constraints on this scenario. In this work, we present in detail the arguments behind the robustness of this result against scanning over the large number of parameters in phenomenological minimal Supersymmetric standard model. The Run 3 of LHC will be crucial in probing the surviving regions of the parameter space. We further investigate the impact of light staus on our parameter space and also provide benchmarks that can be interesting for Run 3 of LHC. We analyze these benchmarks at the LHC using the machine learning framework of . Finally, we also discuss the effect of nonstandard cosmology on the parameter space. Published by the American Physical Society 2025

Barman, Rahool Kumar↗
DOE OSTI2020

Nuclear effective field theory: Status and perspectives

The nuclear physics landscape has been redesigned as a sequence of effective field theories (EFTs) connected to the Standard Model through symmetries and lattice simulations of Quantum Chromodynamics (QCD). EFTs in this sequence are expansions around different low-energy limits of QCD, each with its own characteristics, scales, and ranges of applicability regarding energy and number of nucleons. We review each of the three main nuclear EFTs---Chiral, Pionless, Halo/Cluster---highlighting their similarities, differences, and connections. Here, in doing so, we survey the structural properties and reactions of nuclei that have been derived from the \abinitio solution of the few- and many-body problem built upon EFT input.

73 NUCLEAR PHYSICS AND RADIATION PHYSICS↗
DOE OSTI2017

Status of the 16 T Dipole Development Program for a Future Hadron Collider

A next step of energy increase of hadron colliders beyond the LHC requires high-field superconducting magnets capable of providing a dipolar field in the range of 16 T in a 50-mm aperture with accelerator quality. These elements could meet the requirements for an upgrade of the LHC to twice the present beam energy or for a 100-TeV center of mass energy future circular collider. Here, we summarize the activities and plans for the development of these magnets, in particular within the 16 T Magnet Technology Program, the WP5 of the EuroCirCol, and the U.S. Magnet Development Program.

43 PARTICLE ACCELERATORS↗
DOE OSTI2023

Status of the MQXFB Nb 3 Sn Quadrupoles for the HL-LHC

Here, the cold powering test of the first two prototypes of the MQXFB quadrupoles (MQXFBP1, now disassembled, and MQXFBP2), the Nb 3 Sn inner triplet magnets to be installed in the HL-LHC, has validated many features of the design, such as field quality and quench protection, but has found performance limitations. In fact, both magnets showed a similar phenomenology, characterized by reproducible quenches in the straight part inner layer pole turn, with absence of training and limiting the performance at 93% (MQXFBP1) and 98% (MQXFBP2) of the nominal current at 1.9 K, required for HL-LHC operation at 7 TeV. Microstructural inspections of the quenching section of the limiting coil in MQXFBP1 have identified fractured Nb 3 Sn sub-elements in strands located at one specific position of the inner layer pole turn, allowing to determine the precise origin of the performance limitation. In this paper we outline the strategy that has been defined to address the possible sources of performance limitation, namely coil manufacturing, magnet assembly and integration in the cold mass.

72 PHYSICS OF ELEMENTARY PARTICLES AND FIELDS↗