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NASA's Biological Crystal Growth Program on the International Space Station

NASA's Biological Crystal Growth Program (BCG) on the International Space Station (ISS) will consist of two phases. The first phase is during assembly of the ISS and will accommodate generic payloads that currently fly in the orbiter middeck. The second phase is after assembly of the ISS is complete and BCG payloads will occupy part of the Biotechnology Facility aboard the ISS. During both phases of the program, there will be two types of BCG payloads. One type will emphasize the production of crystals for structure determination back on Earth and will have high capacity for screening crystallization conditions. The second type of payload will be designed to study the crystallization process with the primary aim of developing new methods to further optimize the use of the microgravity environment. Beginning immediately, access to the BCG program for Guest Investigators is simplified. Access to all BCG hardware for Guest Investigators will be coordinated through one office at NASA's Marshall Space Flight Center. Details of how to obtain access to microgravity, the hardware available, and the operational aspects of the program will be described.

Kundrot, Craig E.↗

Wilberforce Power Technology in Education Program

The Wilberforce Power Technology in Education Program is a multipart program. Three key parts of this program will be described. They are: (1) WISE-The Wilberforce Summer Intensive Experience. This annual offering is an educational program which is designed to provide both background reinforcement and a focus on study skills to give the participants a boost in their academic performance throughout their academic careers. It is offered to entering Wilberforce students. Those students who take advantage of WISE learn to improve important skills which enable them to work at higher levels in mathematics, science and engineering courses throughout their college careers, but most notably in the first year of college study. (2) Apply technology to reaming. This is being done in several ways including creating an electronic chemistry text with hypertext links to a glossary to help the students deal with the large new vocabulary required to describe and understand chemistry. It is also being done by converting lecture materials for the Biochemistry class to PowerPoint format. Technology is also being applied to learning by exploring simulation software of scientific instrumentation. (3) Wilberforce participation in collaborative research with NASA's John H. Glenn Research Center at Lewis Field. This research has focused on two areas in the past year. The first of these is the deposition of solar cell materials. A second area involves the development of polymeric materials for incorporation into thin film batteries.

Gordon, Edward M.↗

Development of Lightweight Mirror Technology for the NGST Program

Recognizing the need to launch larger aperture telescopes to orbit with current launch capability, the NGST program began in 1997, an aggressive technology development effort in lightweight optics. This effort has developed technologies in silicon Carbide, Beryllium, silicon, glass and hybrid mirrors to name a few. The advancement of mirror technology to below the 15 kg/ni2 areal density is challenging enough without the added requirements for NGST that the mirror operate at approximately 35 Kelvin. This paper will discuss the various NGST technology developments including applications relative to bonding or joining mirror materials, subscale developments, the mirror system demonstrator program, the advance mirror demonstrator program and development of the mirror test program. Specific attention will be given to technical issues related to lightweight mirror development and processing. Other issues to be addressed are the development of the roadmap to the NGST flight mirror development and to assess the technology readiness for NGST.

Jacobson, David N.↗

NASA Microgravity Research Program

The Fiscal Year 1998 Annual Report describes key elements of the NASA Microgravity Research Program. The Program's goals, approach taken to achieve those goals, and program resources are summarized. A review of the Program's status at the end of FY1998 and highlights of the ground- and-flight-based research are provided.

Woodard, Dan↗

Sensors 2000! Program: Advanced Biosensor and Measurement Systems Technologies for Spaceflight Research and Concurrent, Earth-Based Applications

Sensors 2000! (S2K!) is a specialized, integrated projects team organized to provide focused, directed, advanced biosensor and bioinstrumentation systems technology support to NASA's spaceflight and ground-based research and development programs. Specific technology thrusts include telemetry-based sensor systems, chemical/ biological sensors, medical and physiological sensors, miniaturized instrumentation architectures, and data and signal processing systems. A concurrent objective is to promote the mutual use, application, and transition of developed technology by collaborating in academic-commercial-govemment leveraging, joint research, technology utilization and commercialization, and strategic partnering alliances. Sensors 2000! is organized around three primary program elements: Technology and Product Development, Technology infusion and Applications, and Collaborative Activities. Technology and Product Development involves development and demonstration of biosensor and biotelemetry systems for application to NASA Space Life Sciences Programs; production of fully certified spaceflight hardware and payload elements; and sensor/measurement systems development for NASA research and development activities. Technology Infusion and Applications provides technology and program agent support to identify available and applicable technologies from multiple sources for insertion into NASA's strategic enterprises and initiatives. Collaborative Activities involve leveraging of NASA technologies with those of other government agencies, academia, and industry to concurrently provide technology solutions and products of mutual benefit to participating members.

Hines, J.↗

A Program of Research and Education in Aerospace Structures at the Joint Institute for Advancement of Flight Sciences

The objectives of the cooperative effort with NASA was to conduct research related to aerospace structures and to increase the quality and quantity of highly trained engineers knowledgeable about aerospace structures. The program has successfully met the objectives and has been of significant benefit to NASA LARC, the GWU and the nation. The program was initiated with 3 students in 1994 under the direction of Dr. Robert Tolson as the Principal Investigator. Since initiation, 14 students have been involved in the program, resulting in 11 MS degrees with 2 more expected in 2000. The 11 MS theses and projects are listed. For technology transfer purposes some research is not reported in thesis form. Graduates from the program have been hired at aerospace and other companies across the nation, providing GWU and LARC with important industry and government contacts.

Tolson, Robert H.↗

NASA's Space Environments and Effects Program: Technology for the New Millennium

Current trends in spacecraft development include the use of advanced technologies while maintaining the "faster, better, cheaper" philosophy. Spacecraft designers are continually designing with smaller and faster electronics as well as lighter and thinner materials providing better performance, lower weight, and ultimately lower costs. Given this technology trend, spacecraft will become increasingly susceptible to the harsh space environments, causing damaging or even disabling effects on space systems. NASA's Space Environments and Effects (SEE) Program defines the space environments and provides advanced technology development to support the design, development, and operation of spacecraft systems that will accommodate or mitigate effects due to the harsh space environments. This Program provides a comprehensive and focused approach to understanding the space environment, to define the best techniques for both flight and ground-based experimentation, to update the models which predict both the environments and the environmental effects on spacecraft, and finally to ensure that this multitudinous information is properly maintained and inserted into spacecraft design programs. A description of the SEE Program, its accomplishments, and future activities is provided.

Hardage, Donna M.↗

1995 NASA High-Speed Research Program Sonic Boom Workshop: Configuration Design, Analysis, and Testing - Volume 2

The High-Speed Research Program and NASA Langley Research Center sponsored the NASA High-Speed Research Program Sonic Boom Workshop on September 12-13, 1995. The workshop was designed to bring together NASAs scientists and engineers and their counterparts in industry, other Government agencies, and academia working together in the sonic boom element of NASAs High-Speed Research Program. Specific objectives of this workshop were to: (1) report the progress and status of research in sonic boom propagation, acceptability, and design; (2) promote and disseminate this technology within the appropriate technical communities; (3) help promote synergy among the scientists working in the Program; and (4) identify technology pacing, the development C, of viable reduced-boom High-Speed Civil Transport concepts. The Workshop was organized in four sessions: Sessions 1 Sonic Boom Propagation (Theoretical); Session 2 Sonic Boom Propagation (Experimental); Session 3 Acceptability Studies-Human and Animal; and Session 4 - Configuration Design, Analysis, and Testing.

High-speed research↗

Mars Program Independent Assessment Team Report

The Mars Climate Orbiter failed to achieve Mars orbit on September 23, 1999. On December 3, 1999, Mars Polar Lander and two Deep Space 2 microprobes failed. As a result, the NASA Administrator established the Mars Program Independent Assessment Team (MPIAT) with the following charter: 1) Review and analyze successes and failures of recent Mars and Deep Space Missions which include: a) Mars Global Surveyor, b) Mars Climate Orbiter, c) Pathfinder, d) Mars Polar Lander, e) Deep Space 1, and f) Deep Space 2; 2) Examine the relationship between and among, NASA Jet Propulsion Laboratory (JPL), California Institute of Technology (Caltech), NASA Headquarters, and industry partners; 3) Assess effectiveness of involvement of scientists; 4) Identify lessons learned from successes and failures; 5) Review revised Mars Surveyor Program to assure lessons learned are utilized; 6) Oversee Mars Polar Lander and Deep Space 2 failure reviews; and 7) Complete by March 15, 2000. In-depth reviews were conducted at NASA Headquarters, JPL, and Lockheed Martin Astronautics (LMA). Structured reviews, informal sessions with numerous Mars Program participants, and extensive debate and discussion within the MPIAT establish the basis for this report. The review process began on January 7, 2000, and concluded with a briefing to the NASA Administrator on March 14, 2000. This report represents the integrated views of the members of the MPIAT who are identified in the appendix. In total, three related reports have been produced: a summary report, this report entitled "Mars Program Independent Assessment Team Report," and the "Report on the Loss of the Mars Polar Lander and Deep Space 2 Missions".

Young, Thomas↗

Cassini Environmental Test and Analysis Program Summary

This paper presents an overview of the Cassini Project's environmental test and analysis program during thc spacecraft development phase - October 1989 to launch on October 1997. It describes the program's objectives and requirements, summarizes the approach used to achieve them, and provides the margins that were achieved in the final design. Assembly and system level environmental tests that were performed included dynamic, thermal, electromagnetic compatibility (EMC), and magnetic tests. Analysis was used to verify that the environmental requirements of radiation, solid particles including micrometeoroids, and single event effects have been satisfied. The environmental program implemented on Cassini satisfied the spirit and intent of the requirements imposed by the Project during the spacecraft's development. The lessons learned from the Cassini environmental program are discussed.

Hoffman, Alan R.↗

High-Lift Engine Aeroacoustics Technology (HEAT) Test Program Overview

The NASA High-Speed Research program developed the High-Lift Engine Aeroacoustics Technology (HEAT) program to demonstrate satisfactory interaction between the jet noise suppressor and high-lift system of a High-Speed Civil Transport (HSCT) configuration at takeoff, climb, approach and landing conditions. One scheme for reducing jet exhaust noise generated by an HSCT is the use of a mixer-ejector system which would entrain large quantities of ambient air into the nozzle exhaust flow through secondary inlets in order to cool and slow the jet exhaust before it exits the nozzle. The effectiveness of such a noise suppression device must be evaluated in the presence of an HSCT wing high-lift system before definitive assessments can be made concerning its acoustic performance. In addition, these noise suppressors must provide the required acoustic attenuation while not degrading the thrust efficiency of the propulsion system or the aerodynamic performance of the high-lift devices on the wing. Therefore, the main objective of the HEAT program is to demonstrate these technologies and understand their interactions on a large-scale HSCT model. The HEAT program is a collaborative effort between NASA-Ames, Boeing Commercial Airplane Group, Douglas Aircraft Corp., Lockheed-Georgia, General Electric and NASA - Lewis. The suppressor nozzles used in the tests were Generation 1 2-D mixer-ejector nozzles made by General Electric. The model used was a 13.5%-scale semi-span model of a Boeing Reference H configuration.

Zuniga, Fanny A.↗

Research Activities within NASA's Morphing Program

In the last decade, smart technologies have become important enabling technologies that cut across traditional boundaries in science and engineering. Here smart is defined as the ability to respond to a stimulus in a predictable and reproducible manner. While multiple successes have been achieved in the laboratory, we have yet to see the general applicability of smart technologies to actual aircraft and spacecraft. The NASA Morphing program is an attempt to couple research across a wide range of disciplines to integrate smart technologies into high payoff applications on aircraft and spacecraft. The program bridges research in several technical disciplines and combines the effort into applications that include active aerodynamic control, active aeroelastic control, and vehicle performance improvement. System studies are used to assess the highest-payoff program objectives, and specific research activities are defined to address the technologies required for development of smart aircraft and spacecraft. This paper will discuss the overall goals of NASA's Morphing program, highlight some of the recent research efforts and discuss the multidisciplinary studies that support that research and some of the challenges associated with bringing the smart technologies to real applications on flight vehicles.

McGowan, Anna-Maria R.↗

The New Millenium Program: Serving Earth and Space Sciences

NASA has exciting plans for space science and Earth observations during the next decade. A broad range of advanced spacecraft and measurement technologies will be needed to support these plans within the existing budget and schedule constraints. Many of these technology needs are common to both NASA's Office of Earth Science (OES) and Office of Space Sciences (OSS). Even though some breakthrough technologies have been identified to address these needs, project managers have traditionally been reluctant to incorporate them into flight programs because their inherent development risk. To accelerate the infusion of new technologies into its OES and OSS missions, NASA established the New Millennium Program (NMP). This program analyzes the capability needs of these enterprises, identifies candidate technologies to address these needs, incorporates advanced technology suites into validation flights, validates them in the relevant space environment, and then proactively infuses the validated technologies into future missions to enhance their capabilities while reducing their life cycle cost. The NMP employs a cross-enterprise Science Working Group, the NASA Enterprise science and technology roadmaps to define the capabilities needed by future Earth and Space science missions. Additional input from the science community is gathered through open workshops and peer-reviewed NASA Research Announcement (NRAs) for advanced measurement concepts. Technology development inputs from the technology organizations within NASA, other government agencies, federally funded research and development centers (FFRDC's), U.S. industry, and academia are sought to identify breakthrough technologies that might address these needs. This approach significantly extends NASA's technology infrastructure. To complement other flight test programs that develop or validate of individual components, the NMP places its highest priority on system-level validations of technology suites in the relevant space environment. This approach is not needed for all technologies, but it is usually essential to validate advanced system architectures or new measurement concepts. The NMP has recently revised its processes for defining candidate validation flights, and selecting technologies for these flights. The NMP now employs integrated project formulation teams, 'Which include scientists, technologists, and mission planners, to incorporate technology suites into candidate validation flights. These teams develop competing concepts, which can be rigorously evaluated prior to selection for flight. The technology providers for each concept are selected through an open, competitive, process during the project formulation phase. If their concept is selected for flight, they are incorporated into the Project Implementation Team, which develops, integrates, tests, launches, and operates the technology validation flight. Throughout the project implementation phase, the Implementation Team will document and disseminate their validation results to facilitate the infusion of their validated technologies into future OSS and OES science missions. The NMP has successfully launched its first two Deep Space flights for the OSS, and is currently implementing its first two Earth Orbiting flights for the OES. The next OSS and OES flights are currently being defined. Even though these flights are focused on specific Space Science and Earth Science themes, they are designed to validate a range of technologies that could benefit both enterprises, including advanced propulsion, communications, autonomous operations and navigation, multifunctional structures, microelectronics, and advanced instruments. Specific examples of these technologies will be provided in our presentation. The processes developed by the NMP also provide benefits across the Space and Earth Science enterprises. In particular, the extensive, nation-wide technology infrastructure developed by the NMP enhances the access to breakthrough technologies for both enterprises.

Li, Fuk K.↗

New Directions in NASA's Biological Crystal Growth Program on the International Space Station

NASA's Biological Crystal Growth Program (BCG) on the International Space Station (ISS) is changing direction from the study of crystallization to an emphasis on producing crystals for structure determination in leading problems in structural biology. The program will consist of two phases. The first phase is during assembly of the ISS and will primarily utilize payloads that currently fly in the orbiter middeck but can be adapted for ISS. The second phase begins after assembly of the ISS is complete and BCG payloads will occupy part of the Biotechnology Facility aboard the ISS. Two types of BCG payloads will be flown. One will emphasize the production of crystals for structure determination back on Earth. These types of payloads will allow hundreds of crystallization conditions to be tested. The second type of payload will be designed to study the crystallization process with the primary aim of assisting the structural biology efforts. Access to these facilities will be through the NASA BCG Guest Investigators program, the NASA Research Announcement, and other opportunities currently being formulated. Details of the crystallization hardware, the application procedures, and the operational aspects of the program will be described.

Kundrot, Craig E.↗

New Directions in NASA's Biological Crystal Growth Program on the International Space Station

NASA's Biological Crystal Growth Program (BCG) on the International Space Station (ISS) is changing direction from the study of crystallization to an emphasis on producing crystals for structure determination in leading problems in structural biology. The program will consist of two phases. The first phase is during assembly of the ISS and will primarily utilize payloads that currently fly in the orbiter middeck but can be adapted for ISS. The second phase begins after assembly of the ISS is complete and BCG payloads will occupy part of the Biotechnology Facility aboard the ISS. Two types of BCG payloads will be flown. One will emphasize the production of crystals for structure determination back on Earth. These types of payloads will allow hundreds of crystallization conditions to be tested. The second type of payload will be designed to study the crystallization process with the primary aim of assisting the structural biology efforts. Access to these facilities will be through the NASA BCG Guest Investigators program, the NASA Research Announcement, and other opportunities currently being formulated. Details of the crystallization hardware, the application procedures, and the operational aspects of the program will be described.

Kundrot, Craig E.↗

Mars Observer Propulsion and Pyrotechnics Corrective Actions Test Program Status-1999

An extensive propulsion and pyrotechnic test program has been in progress at the NASA White Sands Test Facility since 1995. This program created the capabilities to: accurately measure and characterize pyrovalve combustion product blow-by into propellant systems; characterize valve operation using a Velocity Interferometer System for Any Reflector (VISAR); and evaluate hydrazine and monomethylhydrazine thermal decomposition initiated by blow-by. These capabilities were further utilized and refined this year. Low blow-by pyrovalves manufactured by Conax Florida Corporation continued to be evaluated as a potential corrective measure for blow-by induced propellant explosions. Development and testing of various advanced pyrovalves and investigation of explosion mechanisms also continued. Current and near-term testing includes: evaluation of 3/8 in. Conax pyrovalves and other commercially available valves; development and testing of advanced pyrovalve subcomponent technologies including a zero blow-by pyrovalve ram, composite overwrapped ram cylinder, and a zero particulate generating poppet; investigation of non-destructive evaluation techniques to evaluate pyrovalve ram seals; and testing and modeling of pyrotechnically induced explosive hydrazine decomposition. Evaluation of 3/8 in. Conax valves will include operational margin testing to be accomplished at NASA Langley Research Center. The test program also seeks to compile and format significant amounts of data from this and other pyrovalve test programs to generate a pyrovalve applications handbook. The handbook will facilitate formation of standards that ensure safe spacecraft applications. Current data and future plans are discussed, and community interaction is encouraged.

Saulsberry, Regor↗

Novel Approaches to Cellular Transplantation from the US Space Program

Research in the treatment of type I diabetes is entering a new era that takes advantage of our knowledge in an ever increasing variety of scientific disciplines. Some may originate from very diverse sources, one of which is the Space Program at National Aeronautics and Space Administration (NASA). The Space Program contributes to diabetes-related research in several treatment modalities. As an ongoing effort for medical monitoring of personnel involved in space exploration activities NASA and the extramural scientific community investigate strategies for noninvasive estimation of blood glucose levels. Part of the effort in the space protein crystal growth program is high-resolution structural analysis insulin as a means to better understand the interaction with its receptor and with host immune components and as a basis for rational design of a "better" insulin molecule. The Space Program is also developing laser technology for potential early cataract detection as well as a noninvasive analyses for addressing preclinical diabetic retinopathy. Finally, NASA developed an exciting cell culture system that affords some unique advantages in the propagation and maintenance of mammalian cells in vitro. The cell culture system was originally designed to maintain cell suspensions with a minimum of hydrodynamic and mechanical sheer while awaiting launch into microgravity. Currently the commercially available NASA bioreactor (Synthecon, Inc., Houston, TX) is used as a research tool in basic and applied cell biology. In recent years there is continued strong interest in cellular transplantation as treatment for type I diabetes. The advantages are the potential for successful long-term amelioration and a minimum risk for morbidity in the event of rejection of the transplanted cells. The pathway to successful application of this strategy is accompanied by several substantial hurdles: (1) isolation and propagation of a suitable uniform donor cell population; (2) management of host immune rejection; (3) protection from the autoimmune component of the disease; and (4) anatomic placement of the engrafted cells that permits timely response to blood sugar levels as well as effective release and deployment of insulin. Bioreactor technology may provide some critical advances for surmounting some of these scientific hurdles. The NASA bioreactor is a horizontally rotating cylinder that is completely filled with culture medium. Gaseous exchange is maintained by a concentric cylinder of permeable silicon. In slow rotation (15-25 rpm) particles of small mass such as cells and tissue aggregates remain suspended in the rotating body of fluid. This novel approach suspends cells without stirring thus, allowing objects of different size mass to colocate and interact in a very low shear environment. In fact, analysis of the forces acting on individual cells in the rotating bioreactor reveals that the cells are continuously falling through the fluid medium. The conditions in the bioreactor permit assembly of cells into aggregates. three-dimensional tissue growth, synthesis of intercellular matrix,10 differentiation, and some sinusoid formations that may serve as a surrogate vasculature for larger tissue segments.

Pellis, Neal R.↗

An Arbitrary First Order Theory Can Be Represented by a Program: A Theorem

How can we represent knowledge inside a computer? For formalized knowledge, classical logic seems to be the most adequate tool. Classical logic is behind all formalisms of classical mathematics, and behind many formalisms used in Artificial Intelligence. There is only one serious problem with classical logic: due to the famous Godel's theorem, classical logic is algorithmically undecidable; as a result, when the knowledge is represented in the form of logical statements, it is very difficult to check whether, based on this statement, a given query is true or not. To make knowledge representations more algorithmic, a special field of logic programming was invented. An important portion of logic programming is algorithmically decidable. To cover knowledge that cannot be represented in this portion, several extensions of the decidable fragments have been proposed. In the spirit of logic programming, these extensions are usually introduced in such a way that even if a general algorithm is not available, good heuristic methods exist. It is important to check whether the already proposed extensions are sufficient, or further extensions is necessary. In the present paper, we show that one particular extension, namely, logic programming with classical negation, introduced by M. Gelfond and V. Lifschitz, can represent (in some reasonable sense) an arbitrary first order logical theory.

Hosheleva, Olga↗