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At least 1,585 records · Page 88

Sizing of colloidal particle and protein molecules in a hanging fluid drop

We report non-invasive particle size measurements of polystyrene latex colloidal particles and bovine serum albumin (BSA) protein molecules suspended in tiny hanging fluid drops of 30 micro-Liter volume using a newly designed fiber optic probe. The probe is based upon the principles of the technique of dynamic light scattering (DLS). The motivation for this work comes from growing protein crystals in outer space. Protein crystals have been grown previously in hanging drops in microgravity experiments on-board the space shuttle orbiter. However, obtaining quantitative information on nucleation and growth of the protein crystals in real time has always been a desired goal, but hitherto not achieved. Several protein researchers have shown interest in using DLS to monitor crystal growth process in a droplet, but elaborate instrumentation and optical alignment problems have made in-situ applications difficult. We demonstrate that such an experiment is now possible. Our system offers fast (5 seconds) determination of particle size, utilize safe levels of very low laser power (less than or equal to 0.2 mW), a small scattering volume (approximately 2 x 10(exp -5) cu mm) and high spatial coherence (Beta) values. This is a major step forward when compared to currently available DLS systems.

Ansari, Rafat R.↗

Magnetospheric Constellation and Tomography Mission Concept

We describe the basic principles, instrumentation, and feasibility of a multi-satellite mission that combines in situ observations of plasma and electromagnetic fields with radio tomography imaging. We show that a 16-satellite radio tomography experiment can produce two-dimensional images of plasma density in the earth's magnetosphere at sufficient spatial (1/2 R(sub E)) and temporal (approximately 10s) resolution to address key problems of magnetospheric physics. The same mission can incorporate electron and ion analyzers, magnetometers, and electric field instruments on the same spacecraft. We suggest that the large-scale images are more valuable when combined with in situ observations, supporting an unambiguous interpretation of the in situ data and an investigation of the interdependence of small- and large-scale plasma processes.

Ergun, R. E.↗

Observations of Smoke Aerosol from Biomass Burning in Mexico: Effect of Particle Aging on Radiative Forcing and Remote Sensing

We take advantage of the May 1998 biomass burning event in Southern Mexico to test the global applicability of a smoke aerosol size model developed from data observed in South America. The Mexican event is an unique opportunity to observe well-aged, residual smoke. Observations of smoke aerosol size distribution made from vertical profiles of airborne in situ measurements show an inverse relationship between concentration and particle size that suggests the aging process continues more than a week after the smoke is separated from its fire sources. The ground-based radiometer retrievals show that the column-averaged, aged, Mexican smoke particles are larger (diameter = 0.28 - 0.33 micrometers) than the mean smoke particles in South America (diameter = 0.22 - 0.30 micrometers). However, the difference (delta - 0.06 micrometer) translates into differences in backscattering coefficient of only 4-7% and an increase of direct radiative forcing of only 10%.

Remer, Lorraine A.↗

Development of Standardized Lunar Regolith Simulant Materials

Lunar exploration requires scientific and engineering studies using standardized testing procedures that ultimately support flight certification of technologies and hardware. It is necessary to anticipate the range of source materials and environmental constraints that are expected on the Moon and Mars, and to evaluate in-situ resource utilization (ISRU) coupled with testing and development. Physical properties of the regolith dominate processes such as excavation and drilling, while chemical properties dominate processes such as elemental extraction. We describe here the development of standardized lunar regolith simulant (SLRS) materials that are traceable interlaboratory standards for testing and technology development. These SLRS materials must simulate the lunar regolith in terms of physical, chemical, and mineralogical properties. A comprehensive simulant development program has been outlined and is in progress. A summary of these issues is contained in the 2005 Workshop on Lunar Regolith Simulant Materials

Carpenter, P.↗

Sensitivity of Mars surface navigation to timing errors

This study will show that the surface asset positioning process is robust and relatively insensitive to these errors. Indeed, the combination of in-situ and MN orbiter to Earth Doppler data is capable of simultaneously resolving surface asset and MN orbiter positions to an accuracy of 10 m, and clock errors to levels better than 3 msec.

Mars Network navigation timing errors↗

NASA Lunar Mining and Construction Activities and Plans

The Space Exploration Policy enacted by the US Congress in 2005 calls for the US National Aeronautics and Space Administration (NASA) to implement a sustained and affordable human and robotic program to explore the solar system and beyond; Extend human presence across the solar system, starting with a human return to the Moon by the year 2020, in preparation for human exploration of Mars and other destinations; Develop the innovative technologies, knowledge, and infrastructures both to explore and to support decisions about the destinations for human exploration; and Promote international and commercial participation in exploration to further U.S. scientific, security, and economic interests. In 2006, NASA released the Lunar Architecture Study, which proposed establishing a lunar Outpost on the Moon with international participation to extend human presence beyond Earth's orbit, pursue scientific activities, use the Moon to prepare for future human missions to Mars, and expand Earth s economic sphere. The establishment of sustained human presence on the Moon for science and exploration combines the design, integration, and operation challenges experienced from both the short Apollo lunar missions and the build-up and sustained crew operations of the International Space Station (ISS). Apollo experience reminds developers and mission planners that hardware must operate under extremely harsh environmental and abrasive conditions and every kilogram of mass and payload must be critical to achieve the mission s objectives due to the difficulty and cost of reaching the lunar surface. Experience from the ISS reminds developers and mission planners that integration of all hardware must be designed and planned from the start of the program, operations and evolution of capabilities on a continuous basis are important, and long-term life-cycle costs and logistical needs are equally or more important than minimizing early development and test costs. Overarching all of this is the need to implement efforts that are sustainable and affordable. One area NASA is developing that can significantly change how systems required for sustained human presence are designed and integrated, as well as potentially break our reliance on Earth supplied logistics, is In-Situ Resource Utilization (ISRU). ISRU, also known living off the land, involves the extraction and processing of local resources into useful products. In particular, the ability to make propellants, life support consumables, fuel cell reagents, and radiation shielding can significantly reduce the cost, mass, and risk of sustained human activities beyond Earth. Also, the ability to modify the lunar landscape for safer landing, transfer of payloads from the lander an outpost, dust generation mitigation, and infrastructure placement and buildup are also extremely important for long-term lunar operations. While extra-terrestrial excavation, material handling and processing, and site preparation and construction may be new to NASA and other space agencies, there is extensive terrestrial hardware and commercial experience that can be leveraged. This paper will provide an overview of current NASA activities in lunar ISRU mining and construction and how terrestrial experience in these areas are important to achieving the goal of affordable and sustainable human exploration.

Sanders, Gerald B.↗

NASA Lunar Regolith Simulant Program

Lunar regolith simulant production is absolutely critical to returning man to the Moon. Regolith simulant is used to test hardware exposed to the lunar surface environment, simulate health risks to astronauts, practice in situ resource utilization (ISRU) techniques, and evaluate dust mitigation strategies. Lunar regolith simulant design, production process, and management is a cooperative venture between members of the NASA Marshall Space Flight Center (MSFC) and the U.S. Geological Survey (USGS). The MSFC simulant team is a satellite of the Dust group based at Glenn Research Center. The goals of the cooperative group are to (1) reproduce characteristics of lunar regolith using simulants, (2) produce simulants as cheaply as possible, (3) produce simulants in the amount needed, and (4) produce simulants to meet users? schedules.

Edmunson, J.↗

Degradation of TATP, TNT, and RDX using mechanically alloyed metals

Bimetallic alloys prepared in a ball milling process, such as iron nickel (FeNi), iron palladium (FePd), and magnesium palladium (MgPd) provide in situ catalyst system for remediating and degrading nitro explosive compounds. Specifically, munitions, such as, 2,4,6-trinitrotoluene (TNT), cyclo-1,3,5-trimethylene-2,4,6-trinitramine (RDX), nitrocellulose and nitroglycerine that have become contaminants in groundwater, soil, and other structures are treated on site to remediate explosive contamination.

Clausen, Christian↗

Utilizing Ionic Liquids to Enable the Future of Closed-Loop Life Support Technology

Current oxygen recovery technology onboard the International Space Station only recovers approximately 50% of the oxygen from metabolic carbon dioxide, thus requiring resupply mass in order to sustain life onboard. Future long duration manned missions will require maximum oxygen recovery in order to reduce resupply mass. Complete recovery of oxygen can be achieved through Bosch technology. The challenge with this technology is that the solid carbon produced during the process results in undesired catalyst resupply mass. Although there have been several approaches to solve this challenge, in order to totally eliminate the need for resupply only one potential process has been identified. This process is a fully-regenerable Ionic Liquid (IL)-based Bosch system that employs in situ resources. In 2016, efforts were made that proved the feasibility of an IL-based Bosch system. ILs were used to electroplate iron onto a copper substrate and to regenerate the iron by extracting the iron from the copper substrate and product carbon. In 2017, efforts were initiated to scale the proposed technology. Here we report the results of those efforts as well as an IL-based Bosch system concept and basic reactor design.

Brown, Brittany R.↗

Managing Traffic on the Three-Way Street: Steps Toward Closing the Aerosol Forcing Uncertainty Gap

Understanding changes in the radiative forcing of climate is critical for any effort to attribute, mitigate, or predict climate change. Although greenhouse gases (GHGs) contribute most of the radiative forcing, uncertainty in the climate forcing by airborne particles (aerosols) dominates the uncertainty in forcing changes overall. Yet, aerosol forcing has remained virtually undiminished for more than 20 years despite considerable advances in most of the key contributing elements. Satellite and suborbital measurements, as well as modeling, each have essential roles to play in reducing the uncertainty in the aerosol forcing of climate. This presentation will begin by briefly covering the reasons why aerosols are important for climate study, and will then summarize what we are learning about aerosols from current satellite remote-sensing work, and allude to the roles of suborbital measurements and models. Emphasis will be placed on nascent efforts to link satellite data with models, the need to continue as planned current programs supporting advanced, global-scale satellite and surface-based aerosol and precursor gas observations, climate modeling, as well as intensive field campaigns aimed at characterizing the underlying physical and chemical processes involved. The talk will conclude by highlighting new efforts needed to obtain systematic in situ measurements of aerosol microphysical and chemical properties, along with a greater research focus on integrating the unique contributions of measurements and modeling toward reducing the aerosol climate forcing uncertainty gap.

aerosol↗

Ultrashort Pulse Laser Surface Processing Techniques for Sterilization of Metal Surfaces for Planetary Protection

To prevent forward contamination from microbes aboard spacecraft intended to search for extraterrestrial life, there is a need for effective sterilization methods. However, current techniques are both time-consuming and expensive. For example, dry heat sterilization requires removal from the assembly site and several days of treatment. Furthermore, some components such as optics and electronics are not compatible with current sterilization techniques. Here, we report the latest results in our development of a novel femtosecond laser processing technique for the rapid sterilization of spacecraft hardware. Femtosecond lasers produce extremely high photon fluxes (10^29 photons/sec*cm^2, ~0.03 J/cm^2) in extremely short pulses, which can inactivate even stress-tolerant microbial spores with minimal damage to the spacecraft surface. Aluminum coupons were inoculated with specific densities of Bacillus subtilis bacterial endospores. These coupons were treated with various laser illumination parameters. Afterward, metal coupon samples were assayed for viable spores using a polyvinyl alcohol (PVA) peel, serial dilution, and plating for colony-forming units (CFU). Results indicate that with high enough energy density and pulse counts, most bacterial spores are inactivated with minimal damage to the metal. The sterilization is dependent on both the fluence and pulse count. In addition, femtosecond pulses are more effective than longer pulses for inactivation. These experiments have consistently achieved 4-log reduction in viable spores. Sterilization has been achieved on both flat metal coupons and non-flat surfaces with microchannels, with a slight reduction in sterilization efficiency on the uneven surface. The application of air flow during laser processing was also investigated as a way to remove spores that are dislodged from the surface by the laser illumination, which would contribute to the reduction of spacecraft bioburden. With laser processing technology rapidly evolving, our results support the possibility of an extremely rapid, in-situ surface sterilization method for use in spacecraft assembly clean rooms.

Kaleb McQuillan↗

Insights into the methanol synthesis mechanism via CO 2 hydrogenation over Cu-ZnO-ZrO2 catalysts: Effects of surfactant/Cu-Zn-Zr molar ratio

In this study, we evaluated aspects of the CO 2 hydrogenation mechanism, correlating structure-activity relationships of Cu-ZnO-ZrO 2 catalysts prepared by one-pot surfactant-assisted co-precipitation with different surfactant ratios. Identifying the CO 2 hydrogenation pathway intermediates is key to controlling the reaction selectivity. Experimental evidence shows that the CO 2 is dissociating into CO* and O* onto the surface of the Cu-ZnO-ZrO 2 catalyst. The adsorption and dissociation of CO2 were evidenced by a combination of in situ ambient-pressure X-ray Photoelectron Spectroscopy (AP-XPS) and Fourier Transform Infrared Spectroscopy (FTIR) with a transmission cell. AP-XPS showed that the catalysts are composed of a Cu 2+ , Zr 3+ , and Zr 4+ mixture and two kinds of Zn 2+ species. After the H 2 reduction process, only Cu 2+ was reduced to Cu0. The Zn and Zr species were oxidized by the dissociated O* species. In situ transmission FTIR showed that CO was adsorbed onto the Cu+/0 sites. The catalyst with the higher surfactant molar ratio exhibited the highest CO 2 conversion close to the equilibrium conversion, as well as a good methanol formation rate.

36 MATERIALS SCIENCE↗

Tank Waste LDR Organics Data Summary for Sample-and-Send (Rev.1A)

The presence of organic chemicals regulated under the Resource Conservation and Recovery Act (RCRA) Land Disposal Restrictions (LDR) adds complexity to treating and disposing of the low activity fraction of Hanford tank waste if a low temperature treatment method such as grouting is used (SRNL-STI-2020-00228). The complexity arises from the fact that the baseline vitrification method is considered by the Washington State Department of Ecology (Ecology) as providing adequate thermal treatment for organics; a status not automatically extended to a lowtemperature process, such as solidifying the waste in a cementitious waste form. In addition, the Environmental Protection Agency (EPA) LDR program is intended to ensure that wastes are properly treated prior to disposal. Proper treatment makes hazardous waste less harmful to groundwater by reducing the mobility and/or toxicity of the hazardous constituents in the waste. EPA guidance indicates that stabilization/solidification of waste for organics could be considered impermissible dilution under the LDR dilution prohibition. In addition, waste storage activities at Hanford have required transferring and blending waste within the tank system and these activities have potentially altered the concentrations of the hazardous constituents. The LDR dilution prohibition found in 40 Code of Federal Regulations (CFR) 268.3 states that “… no generator, transporter, handler, or owner or operator of a treatment, storage, or disposal facility shall in any way dilute a restricted waste or the residual from treatment of a restricted waste as a substitute for adequate treatment …”. Hence, if LAW is to be treated using low temperature stabilization (such as cementation), then it is important to demonstrate both how past storage activities have contributed to the removal (by vacuum evaporation), or destruction (by in situ decomposition) of the LDR organics and how future retrieval and waste feed preparation will contribute to their removal (by filtration and ion exchange). Demonstrating these processes helps validate that cementation without additional organic treatment does not necessarily represent impermissible dilution. To aid in implementing cementitious solidification of Low Activity Waste (LAW), WRPS has been developing a regulatory and processing LDR treatment variance strategy termed “Sampleand-Send” that relies, in part, on demonstrating that in situ decomposition reactions along with historic evaporation of tank waste has destroyed or removed most of the LDR organics possibly associated with Hanford Tank Waste (SRNL-STI-2020-00582, SRNL-STI-2021-00453, SRNL-STI-2022-00391). Under the Sample-and-Send concept, Hanford tank waste would be retrieved, processed through a Tank-Side Cesium Removal-like system, and staged as a candidate feed that would then be sampled to confirm the waste acceptance criteria is met for solidification in an LAW cementitious treatment facility. If it can be shown that LDR organics are at concentrations below the waste acceptance criteria (WAC) for cementitious stabilization and have been sufficiently removed (by historic evaporation or by filtration and ion exchange during Cs removal), destroyed (by historic in situ decomposition), or are not soluble in LAW above the WAC then additional organic treatment is not needed prior to creating a cementitious final waste form and the concept of Sample-and-Send would be proposed to establish a non-rulemaking site-specific treatment variance using the specified method of treatment “STABL” to remove sampling requirements of the waste form after treatment. Waste not meeting the WAC could either be routed to the Hanford Waste Treatment and Immobilization Plant for LAW vitrification, or further processed by evaporation or chemical oxidation before solidifying in a cementitious waste form. A key component in implementing the Sample-and-Send strategy is identifying which of the 207 LDR organic compounds associated with the RCRA Part A permit application waste codes for the Double Shell Tanks (DSTs) and Single Shell Tanks (SSTs) and any applicable Underlying Hazardous Constituents (UHCs) from 40 CFR 268.48 should be considered as potentially present and thus subject to regulation. In addition, it is also necessary to understand the solubility volatility, and reactivity of these compounds in LAW to identify which of the potentially present LDR organic compounds are not soluble above regulatory levels or are likely to have been removed by historic evaporation or destroyed by in situ decomposition reactions. If there are potentially present LDR organic compounds that have not been removed or destroyed and are soluble above regulatorily significant concentrations then a treatability variance may be needed for these species to eliminate any concerns pertaining to impermissible dilution. The spreadsheet accompanying this calculation report contains the data and logic computations needed to screen the list of 207 LDR organics associated with Hanford tank waste to identify those potentially present and to indicate which compounds may need to be included in a treatability variance.

12 MANAGEMENT OF RADIOACTIVE AND NON-RADIOACTIVE W↗

Performance Evaluation of Staged Bosch Process for CO2 Reduction to Produce Life Support Consumables

Utilizing carbon dioxide to produce water and hence oxygen is critical for sustained manned missions in space, and to support both NASA's cabin Atmosphere Revitalization System (ARS) and In-Situ Resource Utilization (ISRU) concepts. For long term missions beyond low Earth orbit, where resupply is significantly more difficult and costly, open loop ARS, like Sabatier, consume inputs such as hydrogen. The Bosch process, on the other hand, has the potential to achieve complete loop closure and is hence a preferred choice. However, current single stage Bosch reactor designs suffer from a large recycle penalty due to slow reaction rates and the inherent limitation in approaching thermodynamic equilibrium. Developmental efforts are seeking to improve upon the efficiency (hence reducing the recycle penalty) of current single stage Bosch reactors which employ traditional steel wool catalysts. Precision Combustion, Inc. (PCI), with support from NASA, has investigated the potential for utilizing catalysts supported over short-contact time Microlith substrates for the Bosch reaction to achieve faster reaction rates, higher conversions, and a reduced recycle flows. Proof-of-concept testing was accomplished for a staged Bosch process by splitting the chemistry in two separate reactors, first being the reverse water-gas-shift (RWGS) and the second being the carbon formation reactor (CFR) via hydrogenation and/or Boudouard. This paper presents the results from this feasibility study at various operating conditions. Additionally, results from two 70 hour durability tests for the RWGS reactor are discussed.

Vilekar, Saurabh A.↗

BETO 2021 Peer Review - Continuous Enzymatic Hydrolysis Development (CEHD) WBS 2.4.1.101

The Continuous Enzymatic Hydrolysis Development (CEHD) project aims to reduce the cost and commercialization scale-up risks of biorefinery sugar-lignin production through development of a deployable continuous enzymatic hydrolysis (CEH) process. Through the use of external cross flow membrane filtration loops coupled to enzymatic hydrolysis (EH) reactors, pretreated biomass solids and enzymes are retained for reaction while solubilized product sugars are removed in situ, with high extents of conversion achieved through a series of reactor-membrane unit stages. The CEHD project is focused on advancing CEH as a transformational, process-intensified, lower-cost method for producing soluble clarified biomass sugars and insoluble lignin-rich streams than traditional batch enzymatic hydrolysis (BEH). The project's primary objective is to reduce the cost of CEH to be compellingly lower than conventional BEH, 10% lower in year 1 and 20% lower in year 3 (end of project). A related objective is to expand CEH's operating envelope to increase process efficiency. Through more thorough de-risking and demonstration of CEH, in conjunction with building a suite of modeling and optimization tools that allow for more facile rigorous in silico evaluation of novel CEH designs and modalities, this project intends to elevate industry interest in adopting CEH as an improvement over conventional batch processing. This project was merit reviewed in FY20. It's now in its first year of a new 3-year plan spanning FY21-FY23.

29 ENERGY PLANNING, POLICY, AND ECONOMY↗

Alpha-decay induced shortening of fission tracks simulated by in situ ion irradiation

The diffusion of defects (e.g., vacancies and interstitials) and elements used for dating (e.g., He and Pb) in a mineral structure is a thermal process: This is the primary assumption used to determine the age and thermal history of minerals. For instance, thermal history reconstruction, through the number and length distribution of tracks produced by spontaneous fission of 238 U, is obtained by assuming a thermal event to be the only energy source for shortening of fission tracks. Here, we report a new, non-thermal energy source that induces additional shortening of fission tracks by the irradiation of alpha-recoils from the alpha-decay of 238 U and 232 Th. We simulate alpha-decay induced track-shortening by combining ion accelerator irradiations with transmission electron microscopy. This allows for the first observation of track-shrinkage during in situ ion irradiation. We show that rather than alpha-particles, alpha-recoils induce a significant shortening of fission tracks by nuclear-collisions. The shortening of track-length can be quantified as a function of alpha-decay event dose. However, apatite is less sensitive than zircon to this non-thermal process. Furthermore, the findings exemplify the interactions among different types of self-irradiation from alpha-particles, alpha-recoils and fission-fragment nuclei in single mineral grains and have important implications for the use of zircon and apatite for radiometric dating and thermochronology.

73 NUCLEAR PHYSICS AND RADIATION PHYSICS↗

Assessment of Shape Memory Alloys - From Atoms To Actuators - Via In Situ Neutron Diffraction

As shape memory alloys (SMAs) become an established actuator technology, it is important to identify the fundamental mechanisms responsible for their performance by understanding microstructure performance relationships from processing to final form. Yet, microstructural examination of SMAs at stress and temperature is often a challenge since structural changes occur with stress and temperature and microstructures cannot be preserved through quenching or after stress removal, as would be the case for conventional materials. One solution to this dilemma is in situ neutron diffraction, which has been applied to the investigation of SMAs and has offered a unique approach to reveal the fundamental micromechanics and microstructural aspects of bulk SMAs in a non-destructive setting. Through this technique, it is possible to directly correlate the micromechanical responses (e.g., internal residual stresses, lattice strains), microstructural evolutions (e.g., texture, defects) and phase transformation properties (e.g., phase fractions, kinetics) to the macroscopic actuator behavior. In this work, in situ neutron diffraction was systematically employed to evaluate the deformation and transformation behavior of SMAs under typical actuator conditions. Austenite and martensite phases, yield behavior, variant selection and transformation temperatures were characterized for a polycrystalline NiTi (49.9 at. Ni). As the alloy transforms under thermomechanical loading, the measured textures and lattice plane-level variations were directly related to the cyclic actuation-strain characteristics and the dimensional instability (strain ratcheting) commonly observed in this alloy. The effect of training on the shape memory characteristics of the alloy and the development of two-way shape memory effect (TWSME) were also assessed. The final conversion from a material to a useful actuator, typically termed shape setting, was also investigated in situ during constrained heatingcooling and subsequent shape recovery experiments. Neutron diffraction techniques are also being applied to the investigation of novel high temperature SMAs with the objective of designing alloys with better stability, higher transition temperatures and ultimately superior durability.

Shape Memory Alloys↗

In situ liquid SIMS analysis of uranium oxide

Trace analysis of nuclear materials in solid particles collected in the environment or particles in liquid slurry generated in nuclear material manufacturing processes can pinpoint elemental, organic, and isotopic signatures of nuclear fuel cycle activities and processes. Such information can support nuclear safeguards programs by increasing our ability to detect undeclared nuclear materials, routine activities for safeguarding at declared facilities, and illicit activities. However, trace radioactive material analysis in liquids and slurries is challenging using bulk approaches. For example, one drawback of sensitive analysis such as inductively coupled plasma mass spectrometry (ICP-MS) is that sample is consumed or destroyed as a result of the technical approach. We developed a vacuum compatible microfluidic interface to enable surface analysis of liquids and liquid-solid interactions using time-of-flight secondary ion mass spectrometry (ToF-SIMS). In this work, we illustrate initial results of liquid standards containing uranium using in situ liquid SIMS. Specifically a series of diluted uranium standards used for ICPMS analysis were studied and the limit of detection was estimated. Since the liquid SIMS analysis is almost nondestructive, the same sample can be analyzed by other more destructive approaches afterwards or saved for future references. Consequently, multimodal analysis is possible. Our results demonstrate that in situ liquid SIMS can be used as a new approach to analyze radioactive materials in liquid and slurry forms of relevance to the IAEA safeguards missions.

In situ liquid ToF-SIMS, uranium, limit of detecti↗