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At least 1,585 records · Page 88

PM10 exposure is associated with increased hospitalizations for respiratory syncytial virus bronchiolitis among infants in Lombardy, Italy

Highlights: • Respiratory syncytial virus bronchiolitis (RSV-B) might be influenced by air pollution. • PM10 was associated with RSV-B hospitalizations among infants in Lombardy, Italy. • The most relevant exposure windows were the 2 weeks preceding hospitalization. Respiratory syncytial virus (RSV) is the primary cause of acute lower respiratory infections in children, bronchiolitis in particular. Airborne particulate matter (PM) may influence the children's immune system and foster the spread of RSV infection. We aimed to verify whether PM10 exposure is associated with hospitalization due to RSV bronchiolitis. We selected hospital discharge records (HRD) with ICD-9-CM code 466.11 of infants < 1 year of age, occurring in the epidemic seasons of two years (2012–2013) in Lombardy, Italy. Cases were assigned daily PM10 and apparent temperature levels of the capital city of their residential province. Different exposure windows were considered: single days preceding hospitalization (lag 0 to 30), their average estimates (lag 0–1 to 0–30), and the four weeks preceding hospitalization (week 1 to 4). Negative binomial regression models adjusted for apparent temperature and season were applied to the daily counts of hospitalizations in each province. Results were expressed as incidence rate ratios (IRR) and 95% confidence intervals (95%CI) per 10 µg/m{sup 3} increase in PM10 concentration. Random effects meta-analyses of province-specific IRR were performed to obtain regional estimates. 2814 HRD met our inclusion criteria; males represented about 55% of the cases. A 6% increased risk of hospitalization (95%CI: 1.03–1.10) was found at lag 0 and an almost overlapping 7% increase at lag 1. IRR ranged from 1.03 to 1.05 between lags 2 and 11. No increased risk was observed from lag 12. When considering averaged daily lags, risk estimates gradually increased in the two weeks preceding hospitalization from 1.08 (1.04–1.12) at lag 0–1 to 1.15 (1.08–1.23) between lags 0–11 and 0–13. Analyses on weekly lags showed a risk increase of 6% (1.01–1.12) during week 1 and of 7% (1.02–1.13) during week 2. Our study found a clear association between short- and medium-term PM10 exposures and increased risk of hospitalization due to RSV bronchiolitis among infants.

54 ENVIRONMENTAL SCIENCES↗

Measurements of 14 C in ancient ice from Taylor Glacier, Antarctica constrain in situ cosmogenic 14 CH 4 and 14 CO production rates

Carbon-14 ( 14 C) is incorporated into glacial ice by trapping of atmospheric gases as well as direct near-surface in situ cosmogenic production. 14 C of trapped methane ( 14 CH 4 ) is a powerful tracer for past CH 4 emissions from “old” carbon sources such as permafrost and marine CH 4 clathrates. 14 C in trapped carbon dioxide ( 14 CO 2 ) can be used for absolute dating of ice cores. In situ produced cosmogenic 14 C in carbon monoxide ( 14 CO) can potentially be used to reconstruct the past cosmic ray flux and past solar activity. Unfortunately, the trapped atmospheric and in situ cosmogenic components of 14 C in glacial ice are difficult to disentangle and a thorough understanding of the in situ cosmogenic component is needed in order to extract useful information from ice core 14 C. Here, we analyzed very large (≈1000 kg) ice samples in the 2.26–19.53 m depth range from the ablation zone of Taylor Glacier, Antarctica, to study in situ cosmogenic production of 14 CH 4 and 14 CO. All sampled ice is >50 ka in age, allowing for the assumption that most of the measured 14 C originates from recent in situ cosmogenic production as ancient ice is brought to the surface via ablation. Our results place the first constraints on cosmogenic 14 CH 4 production rates and improve on prior estimates of 14 CO production rates in ice. We find a constant 14 CH 4 / 14 CO production ratio (0.0076 ± 0.0003) for samples deeper than 3 m, which allows the use of 14 CO for correcting the 14 CH 4 signals for the in situ cosmogenic component. Our results also provide the first unambiguous confirmation of 14 C production by fast muons in a natural setting (ice or rock) and suggest that the 14 C production rates in ice commonly used in the literature may be too high.

58 GEOSCIENCES↗

Tangent functional connectomes uncover more unique phenotypic traits

Functional connectomes (FCs) containing pairwise estimations of functional couplings between pairs of brain regions are commonly represented by correlation matrices. As symmetric positive definite matrices, FCs can be transformed via tangent space projections, resulting into tangent-FCs. Tangent-FCs have led to more accurate models predicting brain conditions or aging. Motivated by the fact that tangent-FCs seem to be better biomarkers than FCs, we hypothesized that tangent-FCs have also a higher fingerprint. We explored the effects of six factors: fMRI condition, scan length, parcellation granularity, reference matrix, main-diagonal regularization, and distance metric. Our results showed that identification rates are systematically higher when using tangent-FCs across the “fingerprint gradient” (here including test-retest, monozygotic and dizygotic twins). Highest identification rates were achieved when minimally (0.01) regularizing FCs while performing tangent space projection using Riemann reference matrix and using correlation distance to compare the resulting tangent-FCs. Such configuration was validated in a second dataset (resting-state).

59 BASIC BIOLOGICAL SCIENCES↗

Effect of heat treatment variables on the formation of precipitate free zones (PFZs) in Mg-8Al-0.5Zn alloy

Highlights: • The effect of heat treatment variables on the development of PFZs in the AZ80 Mg alloy has been systematically examined. • PFZ width is found to be strongly dependant on aging temperature as compared to aging time. • The PFZ width in the AZ80 alloy is found to be weakly dependant on the solution temperature and quenching rate. • The solute depletion is found to be the dominant factor in explaining the evolution of PFZ width. - Abstract: The present study is focussed on investigating the effect of heat treatment variables on the formation of precipitate free zones (PFZs) in the AZ80 Mg alloy. The effect of solutionizing temperature, quenching media, aging temperature and time on the PFZ development has been systematically examined. Scanning electron microscopy and nanoindentation were employed to characterize the PFZ regions. Electron probe micro analysis (EPMA) was used to examine the role of solute depletion in the formation of these zones. Moreover, the estimation of vacancy concentration profiles near the grain boundary was used to investigate the role of vacancy depletion. The solute depletion is found to be the dominant mechanism in the development of PFZ regions as compared to vacancy.

36 MATERIALS SCIENCE↗

The supernova progenitor mass distributions of M31 and M33: further evidence for an upper mass limit

Using Hubble Space Telescope photometry to measure star formation histories, we age-date the stellar populations surrounding supernova remnants (SNRs) in M31 and M33. We then apply stellar evolution models to the ages to infer the corresponding masses for their supernova progenitor stars. We analyze 33 M33 SNR progenitors and 29 M31 SNR progenitors in this work. We then combine these measurements with 53 previously published M31 SNR progenitor measurements to bring our total number of progenitor mass estimates to 115. To quantify the mass distributions, we fit power laws of the form dN/dM∝M {sup –α}. Our new larger sample of M31 progenitors follows a distribution with α=4.4{sub −0.4}{sup +0.4}, and the M33 sample follows a distribution with α=3.8{sub −0.5}{sup +0.4}. Thus both samples are consistent within the uncertainties, and the full sample across both galaxies gives α=4.2{sub −0.3}{sup +0.3}. Both the individual and full distributions display a paucity of massive stars when compared to a Salpeter initial mass function, which we would expect to observe if all massive stars exploded as SN that leave behind observable SNR. If we instead fix α = 2.35 and treat the maximum mass as a free parameter, we find M {sub max} ∼ 35-45 M {sub ☉}, indicative of a potential maximum cutoff mass for SN production. Our results suggest that either SNR surveys are biased against finding objects in the youngest (<10 Myr old) regions, or the highest mass stars do not produce SNe.

79 ASTRONOMY AND ASTROPHYSICS↗

ON THE EXPANSION RATE, AGE, AND DISTANCE OF THE SUPERNOVA REMNANT G266.2–1.2 (Vela Jr.)

An analysis of Chandra ACIS data for two relatively bright and narrow portions of the northwestern rim of G266.2–1.2 (a.k.a. RX J0852.0-4622 or Vela Jr.) reveal evidence of a radial displacement of 2.40 ± 0.56 arcsec between 2003 and 2008. The corresponding expansion rate (0.42 ± 0.10 arcsec yr{sup –1} or 13.6% ± 4.2% kyr{sup –1}) is about half the rate reported for an analysis of XMM-Newton data from a similar, but not identical, portion of the rim over a similar, but not identical, time interval (0.84 ± 0.23 arcsec yr{sup –1}). If the Chandra rate is representative of the remnant as a whole, then the results of a hydrodynamic analysis suggest that G266.2–1.2 is between 2.4 and 5.1 kyr old if it is expanding into a uniform ambient medium (whether or not it was produced by a Type Ia or Type II event). If the remnant is expanding into the material shed by a steady stellar wind, then the age could be as much as 50% higher. The Chandra expansion rate and a requirement that the shock speed be greater than or equal to 1000 km s{sup –1} yields a lower limit on the distance of 0.5 kpc. An analysis of previously published distance estimates and constraints suggests G266.2–1.2 is no further than 1.0 kpc. This range of distances is consistent with the distance to the nearer of two groups of material in the Vela Molecular Ridge (0.7 ± 0.2 kpc) and to the Vel OB1 association (0.8 kpc)

79 ASTRONOMY AND ASTROPHYSICS↗

STELLAR PARAMETERS FOR HD 69830, A NEARBY STAR WITH THREE NEPTUNE MASS PLANETS AND AN ASTEROID BELT

We used the CHARA Array to directly measure the angular diameter of HD 69830, home to three Neptune mass planets and an asteroid belt. Our measurement of 0.674 ± 0.014 mas for the limb-darkened angular diameter of this star leads to a physical radius of R {sub *} = 0.9058 ± 0.0190 R {sub ☉} and luminosity of L {sub *} = 0.622 ± 0.014 L {sub ☉} when combined with a fit to the spectral energy distribution of the star. Placing these observed values on an Hertzsprung-Russel diagram along with stellar evolution isochrones produces an age of 10.6 ± 4 Gyr and mass of 0.863 ± 0.043 M {sub ☉}. We use archival optical echelle spectra of HD 69830 along with an iterative spectral fitting technique to measure the iron abundance ([Fe/H] = –0.04 ± 0.03), effective temperature (5385 ± 44 K), and surface gravity (log g = 4.49 ± 0.06). We use these new values for the temperature and luminosity to calculate a more precise age of 7.5 ± 3 Gyr. Applying the values of stellar luminosity and radius to recent models on the optimistic location of the habitable zone produces a range of 0.61-1.44 AU; partially outside the orbit of the furthest known planet (d) around HD 69830. Finally, we estimate the snow line at a distance of 1.95 ± 0.19 AU, which is outside the orbit of all three planets and its asteroid belt.

79 ASTRONOMY AND ASTROPHYSICS↗

Evaluating the simulated mean soil carbon transit times by Earth system models using observations

One known bias in current Earth system models (ESMs) is the underestimation of global mean soil carbon (C) transit time ( τ soil ), which quantifies the age of the C atoms at the time they leave the soil. However, it remains unclear where such underestimations are located globally. Here, we constructed a global database of measured τ soil across 187 sites to evaluate results from 12 ESMs. The observations showed that the estimated τ soil was dramatically shorter from the soil incubation studies in the laboratory environment (median = 4 years; interquartile range = 1 to 25 years) than that derived from field in situ measurements (31; 5 to 84 years) with shifts in stable isotopic C( 13 C ) or the stock-over-flux approach. In comparison with the field observations, the multi-model ensemble simulated a shorter median (19 years) anda smaller spatial variation (6 to 29 years) of τ soil across the same site locations. We then found a significant and negative linear correlation between the in situ measured τ soil and mean annual air temperature. The underestimations of modeled τ soil are mainly located in cold and dry biomes, especially tundra and desert.Furthermore, we showed that one ESM (i.e., CESM) has improved its τ soil estimate by incorporation of the soil vertical profile. These findings indicate that the spatial variation of τ soil is a useful benchmark for ESMs, and we recommend more observations and modeling efforts on soil C dynamics in regions limited by temperature and moisture.

54 ENVIRONMENTAL SCIENCES↗

Requirements for a global data infrastructure in support of CMIP6

The World Climate Research Programme (WCRP)'s Working Group on Climate Modelling (WGCM) Infrastructure Panel (WIP) was formed in 2014 in response to the explosive growth in size and complexity of Coupled Model Intercomparison Projects (CMIPs) between CMIP3 (2005–2006) and CMIP5 (2011–2012). This article presents the WIP recommendations for the global data infrastructure needed to support CMIP design, future growth, and evolution. Developed in close coordination with those who build and run the existing infrastructure (the Earth System Grid Federation; ESGF), the recommendations are based on several principles beginning with the need to separate requirements, implementation, and operations. Other important principles include the consideration of the diversity of community needs around data – a data ecosystem – the importance of provenance, the need for automation, and the obligation to measure costs and benefits. This paper concentrates on requirements, recognizing the diversity of communities involved (modelers, analysts, software developers, and downstream users). Such requirements include the need for scientific reproducibility and accountability alongside the need to record and track data usage. One key element is to generate a dataset-centric rather than system-centric focus, with an aim to making the infrastructure less prone to systemic failure. With these overarching principles and requirements, the WIP has produced a set of position papers, which are summarized in the latter pages of this document. They provide specifications for managing and delivering model output, including strategies for replication and versioning, licensing, data quality assurance, citation, long-term archiving, and dataset tracking. They also describe a new and more formal approach for specifying what data, and associated metadata, should be saved, which enables future data volumes to be estimated, particularly for well-defined projects such as CMIP6. The paper concludes with a future facing consideration of the global data infrastructure evolution that follows from the blurring of boundaries between climate and weather, and the changing nature of published scientific results in the digital age.

54 ENVIRONMENTAL SCIENCES↗

Metamorphosed CM and CI Carbonaceous Chondrites Could Be from the Breakup of the Same Earth-crossing Asteroid

Far from being the relatively unprocessed materials they were once believed to be, we now know that a significant number of carbonaceous chondrites were thermally metamorphosed on their parent asteroid(s). Numerous studies indicate that 7 "CM" and 2 "CI" chondrites have been naturally heated, variously, at from 400 to over 700 C on their parent asteroid(s). Petrographic textures reveal that this thermal metamorphism occurred after the dominant aqueous alteration phase, although some meteorites show evidence of a heating event between two aqueous alteration episodes, i.e. pro- and retrograde aqueous alteration. Aside from the issues of the identification of the transient heat source, timing of metamorphism, and the relation of these materials (if any) to conventional CM and CI chondrites, there is also a mystery related to their recovery. All of these meteorites have been recovered from the Antarctic; none are falls or finds from anyplace else. Indeed, the majority have been collected by the Japanese NIPR field parties in the Yamato Mountains. In fact, one estimate is that these meteorites account for approx. 64 wt% of the CM carbonaceous chondrites at the NIPR. The reasons for this are unclear and might be due in part to simple sampling bias. However we suggest that this recovery difference is related to the particular age of the Yamato Mountains meteorite recovery surfaces, and differences in meteoroid fluxes between the Yamato meteorites and recent falls and substantially older Antarctic meteorites. Additional information is included in the original extended abstract.

Zolensky, Michael↗

Temporal Decrease in Upper Atmospheric Chlorine

We report a steady decrease in the upper stratospheric and lower mesospheric abundances of hydrogen chloride (HCl) from August 2004 through January 2006, as measured by the Microwave Limb Sounder (MLS) aboard the Aura satellite. For 60(deg)S to 60(deg)N zonal means, the average yearly change in the 0.7 to 0.1 hPa (approx.50 to 65 km) region is -27 +/- 3 pptv/year, or -0.78 +/- 0.08 percent/year. This is consistent with surface abundance decrease rates (about 6 to 7 years earlier) in chlorine source gases. The MLS data confirm that international agreements to reduce global emissions of ozone-depleting industrial gases are leading to global decreases in the total gaseous chlorine burden. Tracking stratospheric HCl variations on a seasonal basis is now possible with MLS data. Inferred stratospheric total chlorine (CITOT) has a value of 3.60 ppbv at the beginning of 2006, with a (2-sigma) accuracy estimate of 7%; the stratospheric chlorine loading has decreased by about 43 pptv in the 18-month period studied here. We discuss the MLS HCl measurements in the context of other satellite-based HCl data, as well as expectations from surface chlorine data. A mean age of air of approx. 5.5 years and an age spectrum width of 2 years or less provide a fairly good fit to the ensemble of measurements.

chlorine↗

Empirical Validation of UBEM: An Assessment of Bias in Urban Building Energy Modeling for Chicago

Residential and commercial buildings currently account for 30% of total global final energy consumption. Urban-scale building energy modeling (UBEM) can enable scalable investments and unlock building improvements by quantifying energy, demand, emissions, and cost reductions of specific measures or packages for building-specific technologies in large geographic regions. While the sophistication of UBEM data sources and technologies have increased dramatically in the past decade, there remains a knowledge gap for empirical validation and sources of bias between building-specific energy models and measured data at varying geographic scales.As UBEM continues to develop, systemic analysis of accuracy, bias, and limitations of the resulting models is necessary to inform best practices and move toward standardization. These are characterized for the Automatic Building Energy Modeling (AutoBEM) software suite with an initial case study involving metered electricity consumption data from 247,188 buildings in Chicago, Illinois, USA - averaged across years 2019-2021 - compared to the following datasets: (1) the AutoBEM-generated nation-scale Model America version 2 (MAv2) data for 596,064 buildings, (2) tax assessor data for 579,829 buildings, (3) tax assessor data filled with MAv2, and (4) 102 representative dynamic archetypes. The accuracy is reported for every building type and vintage combination, along with multiple sources of bias for unique building descriptors. The AutoBEM simulation workflow produced energy consumption estimates that closely match aggregated metered electricity consumption data for different types of buildings constructed during various time periods at the city scale - with initial normalized mean bias error of 10.9%, and 1.1% after removing outliers. Contribution of statistically significant factors including building type, land use, age, and size to variance in UBEM bias is quantified.

Garg, Ankur↗

Needle age and season influence photosynthetic temperature response and total annual carbon uptake in mature Picea mariana trees

Using seasonal- and cohort-specific photosynthetic temperature response functions, we quantified the physiological significance of maintaining multiple foliar cohorts in mature (~40-45 year old) Picea mariana trees in an ombrotrophic Sphagnum-bog, northern Minnesota, USA. We measured photosynthetic capacity, foliar respiration (Rd), biochemistry and morphology to estimate annual carbon (C) uptake by cohort, season and canopy position. Temperature response of key photosynthetic parameters at 25 C (i.e., light-saturated rate of CO 2 assimilation (Asat), light-saturated rate of Rubisco carboxylation (Vcmax), light-saturated electron transport rate (Jmax)) were clearly dependent on season and were generally less responsive in younger needles. Temperature optimums range between 18.7-23.7, 31.3-38.3 and 28.7-36.7 C for Asat, Vcmax and Jmax respectively. Current-year (Y0) foliage had lower photosynthetic capacities compared to one-year-old (Y1) and two-year-old (Y2) foliage. As Y0 needles matured, values of Asat, Vcmax, Jmax, foliar LMA and nitrogen increased. Values of Vcmax, Jmax and Rd were related to foliar nitrogen but only in the youngest (Y0) cohort. Foliar ontogeny affected photosynthetic capacity more than growth temperature. Morphological and physiological cohort differences were reflected by their annual contribution to modeled C uptake, with a ~36% lower estimated annual C uptake by Y0 needles (LAI 0.52 m 2 m -2 ) compared to Y1&2 cohorts (LAI 0.67 m 2 m -2 ). Collectively, these results illustrate the physiological and ecological significance of characterizing multiple foliar cohorts during bud break and throughout the growth season, and for cumulative C uptake model estimates.

54 ENVIRONMENTAL SCIENCES↗

In the Modern Treatment Era, Is Breast Conservation Equivalent to Mastectomy in Women Younger Than 40 Years of Age? A Multi-Institution Study

Purpose: Mastectomy is often recommended for women ≤40 years of age with breast cancer, as young women were under-represented in the landmark trials comparing breast conservation therapy (BCT) to mastectomy. We hypothesized that, in the modern treatment era, BCT and mastectomy result in equivalent local control rates in young women. Methods and Materials: Breast cancer cases arising between 1975 and 2013 in women ≤40 years old were collected from the tumor registries of 2 large healthcare systems in Utah. Kaplan-Meier estimates and Cox proportional hazards models were used to analyze freedom from locoregional recurrence (FFLR), overall survival (OS), and relapse-free survival (RFS). Results: This analysis identified 853 BCT candidates. A comparison of BCT to mastectomy after 2000 showed FFLR, RFS, and OS were all similar. Rate for FFLR at 10 years was 94.9% versus 92.1% for BCT and mastectomy, respectively (P=.57). For women whose cancer was diagnosed after 2000, who received BCT, FFLR and RFS rates were improved compared to those whose cancer was diagnosed prior to 2000 (P<.05), whereas OS (P=.46) rates were similar. Among those who underwent mastectomy, FFLR, OS, and RFS were significantly improved (P<.05) with diagnosis after 2000. Conclusions: FFLR rates for young women, ≤40 years of age, have significantly improved for BCT and mastectomy over time. If patients were treated after 2000, BCT appears to be safe and equivalent to mastectomy at 10 years in terms of FFLR, OS, and RFS.

62 RADIOLOGY AND NUCLEAR MEDICINE↗

ITAR: A modified TAR method to determine depth dose distribution for an ophthalmic device that performs kilovoltage x-ray pencil-beam stereotaxy

Purpose: New technology has been developed to treat age-related macular degeneration (AMD) using 100 kVp pencil-beams that enter the patient through the radio-resistant sclera with a depth of interest between 1.6 and 2.6 cm. Measurement of reference and relative dose in a kilovoltage x-ray beam with a 0.42 cm diameter field size and a 15 cm source to axis distance (SAD) is a challenge that is not fully addressed in current guidelines to medical physicists. AAPM's TG-61 gives dosimetry recommendations for low and medium energy x-rays, but not all of them are feasible to follow for this modality. Methods: An investigation was conducted to select appropriate equipment for the application. PTW's Type 34013 Soft X-Ray Chamber (Freiburg, Germany) and CIRS's Plastic Water LR (Norfolk, VA) were found to be the best available options. Attenuation curves were measured with minimal scatter contribution and thus called Low Scatter Tissue Air Ratio (LSTAR). A scatter conversion coefficient (C{sub scat}) was derived through Monte Carlo radiation transport simulation using MCNPX (LANL, Los Alamos, NM) to quantify the difference between a traditional TAR curve and the LSTAR curve. A material conversion coefficient (C{sub mat}) was determined through experimentation to evaluate the difference in attenuation properties between water and Plastic Water LR. Validity of performing direct dosimetry measurements with a source to detector distance other than the treatment distance, and therefore a different field size due to a fixed collimator, was explored. A method—Integrated Tissue Air Ratio (ITAR)—has been developed that isolates each of the three main radiological effects (distance from source, attenuation, and scatter) during measurement, and integrates them to determine the dose rate to the macula during treatment. Results: LSTAR curves were determined to be field size independent within the range explored, indicating that direct dosimetry measurements may be performed with a source to detector distance of 20 cm even though the SAD is 15 cm during treatment. C{sub scat} varied from 1.102 to 1.106 within the range of depths of interest. The experimental variance among repeated measurements of C{sub mat} was larger than depth dependence, so C{sub mat} was estimated as1.019 for all depths of interest. Conclusions: Equipment selection, measurement techniques, and formalism for the determination of dose rate to the macula during stereotaxy for AMD have been determined and are strongly recommended by the authors of this paper to be used by clinical medical physicists.

61 RADIATION PROTECTION AND DOSIMETRY↗

An ALMA Survey of Protoplanetary Disks in the σ Orionis Cluster

The σ Orionis cluster is important for studying protoplanetary disk evolution, as its intermediate age (∼3–5 Myr) is comparable to the median disk lifetime. We use ALMA to conduct a high-sensitivity survey of dust and gas in 92 protoplanetary disks around σ Orionis members with M {sub *} ≳ 0.1 M {sub ⊙}. Our observations cover the 1.33 mm continuum and several CO J = 2–1 lines: out of 92 sources, we detect 37 in the millimeter continuum and 6 in {sup 12}CO, 3 in {sup 13}CO, and none in C{sup 18}O. Using the continuum emission to estimate dust mass, we find only 11 disks with M {sub dust} ≳ 10 M {sub ⊕}, indicating that after only a few Myr of evolution most disks lack sufficient dust to form giant planet cores. Stacking the individually undetected continuum sources limits their average dust mass to 5× lower than that of the faintest detected disk, supporting theoretical models that indicate rapid dissipation once disk clearing begins. Comparing the protoplanetary disk population in σ Orionis to those of other star-forming regions supports the steady decline in average dust mass and the steepening of the M {sub dust}– M {sub *} relation with age; studying these evolutionary trends can inform the relative importance of different disk processes during key eras of planet formation. External photoevaporation from the central O9 star is influencing disk evolution throughout the region: dust masses clearly decline with decreasing separation from the photoionizing source, and the handful of CO detections exist at projected separations of >1.5 pc. Collectively, our findings indicate that giant planet formation is inherently rare and/or well underway by a few Myr of age.

79 ASTRONOMY AND ASTROPHYSICS↗

Are State-Sponsored New Radiation Therapy Facilities Economically Viable in Low- and Middle-Income Countries?

Purpose: The economic viability of establishing a state-funded radiation therapy (RT) infrastructure in low- and middle-income countries (LMICs) in accordance with the World Bank definition has been assessed through computation of a return on investment (ROI). Methods and Materials: Of the 139 LMICs, 100 were evaluated according to their RT facilities, gross national income (GNI) per capita, and employment/population ratio. The assumption was an investment of US$5 million for a basic RT center able to treat 1000 patients annually. The national breakeven points and percentage of ROI (%ROI) were calculated according to the GNI per capita and patient survival rates of 10% to 50% at 2 years. It was assumed that 50% of these patients would be of working age and that, if employed and able to work after treatment, they would contribute to the country's GNI for at least 2 years. The cumulative GNI after attaining the breakeven point until the end of the 15-year lifespan of the teletherapy unit was calculated to estimate the %ROI. The recurring and overhead costs were assumed to vary from 5.5% to 15% of the capital investment. Results: The %ROI was dependent on the GNI per capita, employment/population ratio and 2-year patient survival (all P<.001). Accordingly, none of the low-income countries would attain an ROI. If 50% of the patients survived for 2 years, the %ROI in the lower-middle and upper-middle income countries could range from 0% to 159.9% and 11.2% to 844.7%, respectively. Patient user fees to offset recurring and overhead costs could vary from “nil” to US$750, depending on state subsidies. Conclusions: Countries with a greater GNI per capita, higher employment/population ratio, and better survival could achieve a faster breakeven point, resulting in a higher %ROI. Additional factors such as user fees have also been considered. These can be tailored to the patient's ability to pay to cover the recurring costs. Certain pragmatic steps that could be undertaken to address these issues are discussed in the present study.

29 ENERGY PLANNING, POLICY, AND ECONOMY↗

Online technique for detecting state of onboard fiber optic gyroscope

Although angle random walk (ARW) of fiber optic gyroscope (FOG) has been well modeled and identified before being integrated into the high-accuracy attitude control system of satellite, aging and unexpected failures can affect the performance of FOG after launch, resulting in the variation of ARW coefficient. Therefore, the ARW coefficient can be regarded as an indicator of “state of health” for FOG diagnosis in some sense. The Allan variance method can be used to estimate ARW coefficient of FOG, however, it requires a large amount of data to be stored. Moreover, the procedure of drawing slope lines for estimation is painful. To overcome the barriers, a weighted state-space model that directly models the ARW to obtain a nonlinear state-space model was established for FOG. Then, a neural extended-Kalman filter algorithm was implemented to estimate and track the variation of ARW in real time. The results of experiment show that the proposed approach is valid to detect the state of FOG. Moreover, the proposed technique effectively avoids the storage of data.

46 INSTRUMENTATION RELATED TO NUCLEAR SCIENCE AND ↗