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NASA NTRS2001

Effects of Electrons, Protons, and Ultraviolet Radiation on Thermophysical Properties of Polymeric Films

The response of coated thin polymer films to ultraviolet (UV), electron and proton radiation simultaneously has been evaluated, with selected measurements in situ. Exposure was intended to simulate the electron and proton radiation environment near the Earth-Sun Lagrangian points (LI and L2) for five years and approximately 1000 equivalent solar hours (ESH) UV. These orbital environments are relevant to several potential missions such as the Next Generation Space Telescope and Geomagnetic Storm Warning, both of which may use thin film based structures for a sunshade and solar sail, respectively. The thin film candidates (12.5 micrometers thick) consisted of commercially available materials (Kapton(R) E, HN, Upilex(R) S, CP-1, CP-2, TOR-RC, and TOR-LMBP) that were metalized on one side with vapor deposited aluminum. All of the films are aromatic polyimides, with the exception of TORLMBP, which is a copoly(arylene ether benzimidazole). The films were exposed as second surface mirrors and the effects of the exposure on solar absorptance, thermal emittance, and tensile properties were determined. The in situ changes in solar absorptance from Kapton(R) and Upilex(R) were less than 0. 1, whereas the solar absorptance of TOR and CP films increased by more than 0.3 without saturating. The thermal emittance measurements also showed that the Kapton(R) and Upilex(R) materials increased only 1-2%, but the remaining materials increased 5-8%. Based on tensile property measurements made in air following the test, the failure stress of every type of polymer film decreased as a result of irradiation. The polymers most stable in reflectance, namely Upilex(R) and Kapton(R), were also the strongest in tension before irradiation, and they retained the greatest percentage of tensile strength. The films less stable in reflectance were also weaker in tension, and lost more tensile strength as a result of irradiation. The apparent failure strain (as a percent of original gage length) of every type of polymer film except TOR-RC, decreased as a result of irradiation.

Russell, Dennis A.↗

NASA NTRS1992

Automation of closed environments in space for human comfort and safety

This report culminates the work accomplished during a three year design project on the automation of an Environmental Control and Life Support System (ECLSS) suitable for space travel and colonization. The system would provide a comfortable living environment in space that is fully functional with limited human supervision. A completely automated ECLSS would increase astronaut productivity while contributing to their safety and comfort. The first section of this report, section 1.0, briefly explains the project, its goals, and the scheduling used by the team in meeting these goals. Section 2.0 presents an in-depth look at each of the component subsystems. Each subsection describes the mathematical modeling and computer simulation used to represent that portion of the system. The individual models have been integrated into a complete computer simulation of the CO2 removal process. In section 3.0, the two simulation control schemes are described. The classical control approach uses traditional methods to control the mechanical equipment. The expert control system uses fuzzy logic and artificial intelligence to control the system. By integrating the two control systems with the mathematical computer simulation, the effectiveness of the two schemes can be compared. The results are then used as proof of concept in considering new control schemes for the entire ECLSS. Section 4.0 covers the results and trends observed when the model was subjected to different test situations. These results provide insight into the operating procedures of the model and the different control schemes. The appendix, section 5.0, contains summaries of lectures presented during the past year, homework assignments, and the completed source code used for the computer simulation and control system.

Source record↗

NASA NTRS2000

X-38 Experimental Aerothermodynamics

The X-38 program seeks to demonstrate an autonomously returned orbital test flight vehicle to support the development of an operational Crew Return Vehicle for the International Space Station. The test flight, anticipated in 2002, is intended to demonstrate the entire mission profile of returning Space Station crew members safely back to earth in the event of medical or mechanical emergency. Integral to the formulation of the X-38 flight data book and the design of the thermal protection system, the aerothermodynamic environment is being defined through a synergistic combination of ground based testing and computational fluid dynamics. This report provides an overview of the hypersonic aerothermodynamic wind tunnel program conducted at the NASA Langley Research Center in support of the X-38 development. Global and discrete surface heat transfer force and moment, surface streamline patterns, and shock shapes were measured on scaled models of the proposed X-38 configuration in different test gases at Mach 6, 10 and 20. The test parametrics include angle of attack from 0 to 50 degs, unit Reynolds numbers from 0.3 x 10 (exp 6) to 16 x 10 (exp 6)/ ft, rudder deflections of 0, 2, and 5 deg. and body flap deflections from 0 to 30 deg. Results from hypersonic aerodynamic screening studies that were conducted as the configuration evolved to the present shape at, presented. Heavy gas simulation tests have indicated that the primary real gas effects on X-38 aerodynamics at trim conditions are expected to favorably influence flap effectiveness. Comparisons of the experimental heating and force and moment data to prediction and the current aerodynamic data book are highlighted. The effects of discrete roughness elements on boundary layer transition were investigated at Mach 6 and the development of a transition correlation for the X-38 vehicle is described. Extrapolation of ground based heating measurements to flight radiation equilibrium wall temperatures at Mach 6 and 10 were made and generally compared to within 50 deg F of flight prediction.

Horvath, Thomas J.↗

NASA NTRSDate not supplied

Overview of Plume-Surface Interaction Data from Subscale Inert Gas Testing at NASA MSFC Test Stand 300 Vacuum Facilities

Maturation and validation of predictive modeling capabilities for plume-surface interaction, and the effects caused by the impingement of rocket engine exhaust on surface regolith, require relevant, highly characterized ground test data. The multi-phase nature of this problem poses challenges to ground testing across physical scaling, test environments and techniques, and diagnostics. NASA has developed a Physics Focused Ground Test (PFGT) of plume-surface interaction to address this need. The PFGT is a subscale, inert-gas experiment at Mars- and Lunar-relevant ambient pressure conditions that will provide critical data for model validation of cratering, ejecta, and plume physics. In this test, the ambient pressure in a vacuum chamber will be varied, along with the height of a supersonic nozzle above a surface, and the mass flow rate through the nozzle. Testing will be performed on a range of regolith simulants of varying composition and will also include instrumented impingement plate tests in place of regolith simulant to characterize gas-only plume physics. Novel high-speed visual diagnostics will capture temporal data on crater formation and ejecta dynamics, and planar laser-induced fluorescence diagnostics will capture plume structure and behavior. This paper will present an overview of the data collected during this test – for both the cratering and ejecta testing and the gas-only plume physics testing. Emphasis will be placed on trends, effects, and interactions observed in the data across the test parameter space.

Chad J. Eberhart↗

NASA NTRS2010

Lunar Atmosphere and Dust Environment Explorer Integration and Test

Integration and test (I&T) of the Lunar Atmosphere and Dust Environment Explorer (LADEE) is presented. A collaborative NASA project between Goddard Space Flight Center and Ames Research Center, LADEE's mission is to explore the low lunar orbit environment and exosphere for constituents. Its instruments include two spectrometers, a dust detector, and a laser communication technology demonstration. Although a relatively low-cost spacecraft, LADEE has I&T requirements typical of most planetary probes, such as prelaunch contamination control, sterilization, and instrument calibration. To lead to a successful mission, I&T at the spacecraft, instrument, and observatory level must include step-by-step and end-to-end functional, environmental, and performance testing. Due to its compressed development schedule, LADEE I&T planning requires adjusting test flows and sequences to account for long-lead critical-path items and limited spares. A protoflight test-level strategy is also baselined. However, the program benefits from having two independent but collaborative teams of engineers, managers, and technicians that have a wealth of flight project experience. This paper summarizes the LADEE I&T planning, flow, facilities, and probe-unique processes. Coordination of requirements and approaches to I&T when multiple organizations are involved is discussed. Also presented are cost-effective approaches to I&T that are transferable to most any spaceflight project I&T program.

Wright, Michael R.↗

NASA NTRSDate not supplied

LEIA: An Investigation of Radiation Risks to Biology at the Lunar South Pole

Radiation and reduced gravity pose biological risks to crewed deep space exploration. At the cellular level, radiation damage can be amplified by reduced gravity. Empirical evidence on cellular responses to beyond low Earth orbit (BLEO) environments is imperative to develop effective countermeasures for crew health and in-space biomanufacturing. The Lunar Explorer Instrument for Space Biology Applications (LEIA) project is developing an instrument suite to be delivered to the south polar region of the Moon by the Commercial Lunar Payload Services (CLPS) program. This presentation will provide an overview of the LEIA hardware, experiments, and mission timeline. The LEIA instruments include the BioSensor, the ARES charged particle detector, and the Mini-FND. The BioSensor is an autonomous light emitting diode (LED)-based spectrophotometer and microfluidic incubator. The BioSensor activates yeast cultures and can measure cell growth, metabolic activity, and carotenoid production. The ARES is a Timepix-based charged particle radiation detector that measures dose, dose rate, and linear energy transfer spectra. The Mini-FND is a fast neutron detector that measures albedo neutron flux and energy spectra. Combined, these instruments will be used for yeast genetics experiments to quantify growth, metabolism, and synthetic biology-enabled production of human nutrients, while taking real time measurements of biologically relevant radiation exposure on the lunar surface. These data will be used to test the importance of selected DNA damage repair and reactive oxygen species defense pathways in mitigating cellular damage from lunar surface radiation.

Yeast↗

NASA NTRSDate not supplied

LEIA: An Investigation of Radiation Risks to Biology at the Lunar South Pole

Yeast↗

NASA NTRS2001

Accomplishments of the Advanced Reusable Technologies (ART) RBCC Project at NASA/Marshall Space Flight Center

The focus of the NASA / Marshall Space Flight Center (MSFC) Advanced Reusable Technologies (ART) project is to advance and develop Rocket-Based Combined-Cycle (RBCC) technologies. The ART project began in 1996 as part of the Advanced Space Transportation Program (ASTP). The project is composed of several activities including RBCC engine ground testing, tool development, vehicle / mission studies, and component testing / development. The major contractors involved in the ART project are Aerojet and Rocketdyne. A large database of RBCC ground test data was generated for the air-augmented rocket (AAR), ramjet, scramjet, and ascent rocket modes of operation for both the Aerojet and Rocketdyne concepts. Transition between consecutive modes was also demonstrated as well as trajectory simulation. The Rocketdyne freejet tests were conducted at GASL in the Flight Acceleration Simulation Test (FAST) facility. During a single test, the FAST facility is capable of simulating both the enthalpy and aerodynamic conditions over a range of Mach numbers in a flight trajectory. Aerojet performed freejet testing in the Pebble Bed facility at GASL as well as direct-connect testing at GASL. Aerojet also performed sea-level static (SLS) testing at the Aerojet A-Zone facility in Sacramento, CA. Several flight-type flowpath components were developed under the ART project. Aerojet designed and fabricated ceramic scramjet injectors. The structural design of the injectors will be tested in a simulated scramjet environment where thermal effects and performance will be assessed. Rocketdyne will be replacing the cooled combustor in the A5 rig with a flight-weight combustor that is near completion. Aerojet's formed duct panel is currently being fabricated and will be tested in the SLS rig in Aerojet's A-Zone facility. Aerojet has already successfully tested a cooled cowl panel in the same facility. In addition to MSFC, other NASA centers have contributed to the ART project as well. Inlet testing and parametrics were performed at NASA / Glenn Research Center (GRC) and NASA / Langley Research Center (LaRC) for both the Aerojet and Rocketdyne concepts. LaRC conducted an Air-Breathing Launch Vehicle (ABLV) study for several vehicle concepts with RBCC propulsion systems. LaRC is also performing a CFD analysis of the ramjet mode for both flowpaths based on GASL test conditions. A study was performed in 1999 to investigate the feasibility of performing an RBCC flight test on the NASA / Dryden Flight Research Center (DFRC) SR-71 aircraft. Academia involvement in the ART project includes parametric RBCC flowpath testing by Pennsylvania State University (PSU). In addition to thrust and wall static pressure measurements, PSU is also using laser diagnostics to analyze the flowfield in the test rig. MSFC is performing CFD analysis of the PSU rig at select test conditions for model baseline and validation. Also, Georgia Institute of Technology (GT) conducted a vision vehicle study using the Aerojet RBCC concept. Overall, the ART project has been very successful in advancing RBCC technology. Along the way, several major milestones were achieved and "firsts" accomplished. For example, under the ART project, the first dynamic trajectory simulation testing was performed and the Rocketdyne engine A5 logged over one hour of accumulated test time. The next logical step is to develop and demonstrate a flight-weight RBCC engine system.

Nelson, Karl W.↗

NASA NTRS2007

Development of Multifunctional Radiation Shielding Materials for Long Duration Human Exploration Beyond the Low Earth Orbit

One of the major challenges for long duration human exploration beyond the low Earth orbit and sustained human presence on planetary surfaces would be development of materials that would help minimize the radiation exposure to crew and equipment from the interplanetary radiation environment, This radiation environment consists primarily of a continuous flux of galactic cosmic rays (GCR) and transient but intense fluxes of solar energetic particles (SEP). The potential for biological damage by the relatively low percentage of high-energy heavy-ions in the GCR spectrum far outweigh that due to lighter particles because of their ionizing-power and the quality of the resulting biological damage. Although the SEP spectrum does not contain heavy ions and their energy range is much lower than that for GCRs, they however pose serious risks to astronaut health particularly in the event of a bad solar storm The primary purpose of this paper is to discuss our recent efforts in development and evaluation of materials for minimizing the hazards from the interplanetary radiation environment. Traditionally, addition of shielding materials to spacecrafts has invariably resulted in paying a penalty in terms of additional weight. It would therefore be of great benefit if materials could be developed not only with superior shielding effectiveness but also sufficient structural integrity. Such a multifunctional material could then be considered as an integral part of spacecraft structures. Any proposed radiation shielding material for use in outer space should be composed of nuclei that maximize the likelihood of projectile fragmentation while producing the minimum number of target fragments. A modeling based approach will be presented to show that composite materials using hydrogen-rich epoxy matrices reinforced with polyethylene fibers and/or fabrics could effectively meet this requirement. This paper will discuss the fabrication of such a material for a crewed vehicle. Ln addition, the capability of synthesizing radiation shielding materials for habitat structures primarily from Lunar or Martian in-situ resources will also be presented. Such an approach would significantly _reduce the cost associated with transportation of such materials and structures from earth. Results from radiation exposure measurements will be presented demonstrating the shielding effectiveness of the developed materials. Mechanical testing data will be discussed to illustrate that the specific mechanical properties of the developed composites are comparable to structural aluminum based alloys currently used for the space shuttle and space station.

Sen, S.↗

NASA NTRS2017

A Spaceflight Experiment to Determine the Effect of Chamfered Sample Holders on Atomic Oxygen Erosion

The exteriors of low Earth orbit (LEO) spacecraft are subjected to many environmental threats that can cause the surface materials to degrade. One of these threats is atomic oxygen (AO), which is formed by photo dissociation of molecular oxygen by energetic UV radiation. Atomic oxygen exposure can result in oxidative erosion of polymers leading to structural or thermal failure of spacecraft components. The amount of AO erosion expected during a mission can be calculated by knowing the AO erosion yield (Ey, volume loss per incident atom) of the material and the AO fluence expected for the mission. The Ey can be determined through dehydrated mass loss measurements of test samples if one knows the AO fluence, density, and exposure area. Such measurements have been made as part of flight experiments, including the Materials International Space Station Experiment 2 (MISSE 2) Polymers Experiment. The MISSE 2 Polymers Experiment sample holders had chamfered circular apertures that controlled the exposure area, but also allowed some additional AO to scatter from the chamfered edges onto the samples thus causing some samples to erode thru and peel at their perimeter due to this scattering effect. By modeling the scattered AO flux one can predict the actual total AO fluence, and hence more accurate sample Ey. Sample holders with different chamfered-perimeter to exposed-area ratios have been designed for future spaceflight experiments that allow a more accurate determination of the Ey for large area polymers, representative of their use on spacecraft surfaces.

Earth Orbital Environments↗

NASA NTRS2011

Terra and Aqua MODIS Design, Radiometry, and Geometry in Support of Land Remote Sensing

The NASA Earth Observing System (EOS) mission includes the construction and launch of two nearly identical Moderate Resolution Imaging Spectroradiometer (MODIS) instruments. The MODIS proto-flight model (PFM) is onboard the EOS Terra satellite (formerly EOS AM-1) launched on December 18, 1999 and hereafter referred to as Terra MODIS. Flight model-1 (FM1) is onboard the EOS Aqua satellite (formerly EOS PM-1) launched on May 04, 2002 and referred to as Aqua MODIS. MODIS was developed based on the science community s desire to collect multiyear continuous datasets for monitoring changes in the Earth s land, oceans and atmosphere, and the human contributions to these changes. It was designed to measure discrete spectral bands, which includes many used by a number of heritage sensors, and thus extends the heritage datasets to better understand both long- and short-term changes in the global environment (Barnes and Salomonson 1993; Salomonson et al. 2002; Barnes et al. 2002). The MODIS development, launch, and operation were managed by NASA/Goddard Space Flight Center (GSFC), Greenbelt, Maryland. The sensors were designed, built, and tested by Raytheon/ Santa Barbara Remote Sensing (SBRS), Goleta, California. Each MODIS instrument offers 36 spectral bands, which span the spectral region from the visible (0.41 m) to long-wave infrared (14.4 m). MODIS collects data at three different nadir spatial resolutions: 0.25, 0.5, and 1 km. Key design specifications, such as spectral bandwidths, typical scene radiances, required signal-to-noise ratios (SNR) or noise equivalent temperature differences (NEDT), and primary applications of each MODIS spectral band are summarized in Table 7.1. These parameters were the basis for the MODIS design. More details on the evolution of the NASA EOS and development of the MODIS instruments are provided in Chap. 1. This chapter focuses on the MODIS sensor design, radiometry, and geometry as they apply to land remote sensing. With near-daily coverage of the Earth's surface, MODIS provides comprehensive measurements that enable scientists and policy makers to better understand and effectively manage the natural resources on both regional and global scales. Terra, the first large multisensor EOS satellite, is operated in a 10:30 am (local equatorial crossing time, descending southwards) polar orbit. Aqua, the second multisensor EOS satellite is operated in a 1:30 pm (local equatorial crossing time, ascending northwards) polar orbit. With complementing morning and afternoon observations, the Terra and Aqua MODIS, together with other sensors housed on both satellites, have greatly improved our understanding of the dynamics of the global environmental system.

Xiong, Xiaoxiong↗

NASA NTRS2015

GeneLab: A Systems Biology Platform for Spaceflight Omics Data

NASA's mission includes expanding our understanding of biological systems to improve life on Earth and to enable long-duration human exploration of space. Resources to support large numbers of spaceflight investigations are limited. NASA's GeneLab project is maximizing the science output from these experiments by: (1) developing a unique public bioinformatics database that includes space bioscience relevant "omics" data (genomics, transcriptomics, proteomics, and metabolomics) and experimental metadata; (2) partnering with NASA-funded flight experiments through bio-sample sharing or sample augmentation to expedite omics data input to the GeneLab database; and (3) developing community-driven reference flight experiments. The first database, GeneLab Data System Version 1.0, went online in April 2015. V1.0 contains numerous flight datasets and has search and download capabilities. Version 2.0 will be released in 2016 and will link to analytic tools. In 2015 Genelab partnered with two Biological Research in Canisters experiments (BBRIC-19 and BRIC-20) which examine responses of Arabidopsis thaliana to spaceflight. GeneLab also partnered with Rodent Research-1 (RR1), the maiden flight to test the newly developed rodent habitat. GeneLab developed protocols for maxiumum yield of RNA, DNA and protein from precious RR-1 tissues harvested and preserved during the SpaceX-4 mission, as well as from tissues from mice that were frozen intact during spaceflight and later dissected. GeneLab is establishing partnerships with at least three planned flights for 2016. Organism-specific nationwide Science Definition Teams (SDTs) will define future GeneLab dedicated missions and ensure the broader scientific impact of the GeneLab missions. GeneLab ensures prompt release and open access to all high-throughput omics data from spaceflight and ground-based simulations of microgravity and radiation. Overall, GeneLab will facilitate the generation and query of parallel multi-omics data, and deep curation of metadata for integrative analysis, allowing researchers to uncover cellular networks as observed in systems biology platforms. Consequently, the scientific community will have access to a more complete picture of functional and regulatory networks responsive to the spaceflight environment.. Analysis of GeneLab data will contribute fundamental knowledge of how the space environment affects biological systems, and enable emerging terrestrial benefits resulting from mitigation strategies to prevent effects observed during exposure to space. As a result, open access to the data will foster new hypothesis-driven research for future spaceflight studies spanning basic science to translational science.

proteomics↗

NASA NTRSDate not supplied

Predicting Orion Launch Abort Acoustics

Computational fluid dynamics (CFD) scale-resolving simulations were performed to help assess the Orion launch abort system’s vibro-acoustic environment in collaboration with the Orion Loads and Dynamics team at the Johnson Space Center (JSC). The primary objectives are to establish best practices and to validate CFD predictions for surface fluctuating pressure spectra with ground, wind tunnel, and flight test data. Excellent agreement is obtained between CFD predictions by the Cartesian adaptive mesh refinement (AMR) module of the Launch, Ascent, and Vehicle Aerodynamics (LAVA) solver and measurements from a ground test representative of the start of a pad abort scenario, and with measurements from a wind tunnel test case corresponding to a transonic, high total angle of attack ascent abort scenario. A simplified (static and at rest) simulation of a pad abort flight test shows good agreement with the flight data, whereas a more costly simulation where the vehicle is accelerating relative to the ground from rest to Mach 0.4 shows consistent over-prediction of the spectra. Simulation results for a supersonic ascent abort flight test are in reasonable agreement with the measurements, but show larger excursions in regions where non-linear interactions between the plume turbulence, shocks, and turbulent boundary layer are strongest – likely due to CFD modeling assumptions, the effect of which are discussed. Overall, the CFD results demonstrate that scale-resolving simulation methodologies like the one presented can help characterize full-scale launch abort vehicle near-field noise and can complement wind tunnel, ground and flight tests by providing trends and reducing uncertainty for scenarios that cannot or are not planned to be tested.

Orion↗

NASA NTRS2016

Implementation of a Parameterized Interacting Multiple Model Filter on an FPGA for Satellite Communications

In a communications channel, the space environment between a spacecraft and an Earth ground station can potentially cause the loss of a data link or at least degrade its performance due to atmospheric effects, shadowing, multipath, or other impairments. In adaptive and coded modulation, the signal power level at the receiver can be used in order to choose a modulation-coding technique that maximizes throughput while meeting bit error rate (BER) and other performance requirements. It is the goal of this research to implement a generalized interacting multiple model (IMM) filter based on Kalman filters for improved received power estimation on software-dened radio (SDR) technology for satellite communications applications. The IMM filter has been implemented in Verilog consisting of a customizable bank of Kalman filters for choosing between performance and resource utilization. Each Kalman filter can be implemented using either solely a Schur complement module (for high area efficiency) or with Schur complement, matrix multiplication, and matrix addition modules (for high performance). These modules were simulated and synthesized for the Virtex II platform on the JPL Radio Experimenter Development System (EDS) at NASA Glenn Research Center. The results for simulation, synthesis, and hardware testing are presented.

cognitive radio↗

NASA NTRS2018

Bit Error Rate Performance on Passive Alignment in Free Space Optical Links Using Large Core Fibers

A 20-meter free-space optical link (FSOL) is proposed for data transmission between external ISS payload sites and the main cabin at a target rate of 10 Gbps (gigabits per second). Motion between a payload site and the main cabin is predicted to cause up to 5 cm in lateral misalignment and 0.2 degrees of angular misalignment. Due to the harsh environment of space it is advantageous to locate the optical transceivers inside the spacecraft or in a controlled environment. With the optical components and transceivers in separate locations, a fiber optic cable will be required to carry light between the two. In our past work we found that the use of large-core fibers provide an increased misalignment tolerance for such systems and could eliminate the need for active control of the optics. In that work, it was shown that a 105 ïm core diameter fiber optic cable offered a viable low SWaP (size, weight, and power) solution for the ISS application; however, the effects of modal dispersion were not investigated. This paper will present bit error rate performance of the FSOL using these large-core fibers.

Free Space Optical Link↗

NASA NTRS2018

A New Approach to Mission Classification and Risk Management for NASA Space Flight Missions

The NASA risk classification system is meant to uide space mission development from formulation through completion of implementation. It is also meant to be the basis on which program and project managers develop and implement appropriate mission assurance and risk management strategies for the mission. In order to be useful, the risk classification system needs to provide consistent and reproducible classification results so that missions may be designed with the appropriate components, subsystems, and testing philosophy, all of which impacts mission schedule and cost. In a cost-constrained environment, a clear, robust, and reproducible approach to mission implementation becomes more critical than ever before. Once a project's risk classification level is established, the managers can define the appropriate management controls, systems engineering processes, mission assurance requirements, safety, and testing for that mission. The current NASA mission classification system will be reviewed before a new system is proposed.NASA manages space flight missions according to a four-tiered classification which assumes increasing levels of risk. We argue that risk does not change between classes. What changes are the means available to reduce risk. In performance-driven missions, the project will spend money in order to maintain performance without reducing margins. In cost-constrained missions, performance will be reduced in order to stay within budget or to maintain schedule: measurement requirements may be traded, design life may be reduced, or both. We then propose a new approach to the classification of NASA space flight missions, based on an assessment of how flexible the requirements, how exquisite the measurements, how long the lifetime, and how rigid the budget.Our proposed approach makes possible a clearer differentiation between classification levels and more effective guidance to program and project managers.

Bordi, Francesco↗

NASA NTRS2017

Personalized Risk Assesment for Adverse Drug Reactions and Treatment Failures

As NASA and other space agencies prepare for future long-term space missions beyond the LEO, the cumulative impact of risk factors encountered in space increases substantially rising concerns about astronauts health. Application of on-board medications to mitigate clinical symptoms associated with certain medical conditions and illnesses is the first line of response to ensure sustainable health and performance of crew. Unfortunately, very limited research has been conducted to determine efficacy of the earth-based pharmaceuticals in a microgravity environment. In some instances, orally administered medications taken during flight were reported to be less effective than expected. Evaluation of series of experiments involving astronauts from shuttle flights shows notable individual variability to several pharmaceuticals during flight. These data provide reasonable assumption of perturbation in CYP450 enzymes during spaceflight, which contribute to the hepatic metabolism of the majority of drugs and therefore may have significant effects on therapeutic efficacy and increase treatment-related toxicity. The genes encoding the CYP450 enzymes are highly variable in humans. Inheritable variations of CYP450 hepatic metabolizer enzymes and transport proteins play a crucial role in the inter-individual variability of drug efficiency and risks of adverse drug reactions. Additionally, there are some reports that document changes in the levels of production of drug-metabolizing enzymes in microgravity. Therefore, in order to provide a safe and effective pharmaceutical treatment in space, medications selection should be based not only on the specific efficacy of medications but also on the individual drug sensitivity and flight-induced changes in metabolism of astronauts chosen for a particular mission. To our knowledge, there was no pre-flight drug sensitivity testing on a genetic level for any of the previous manned NASA space missions. Therefore, technologies capable of predicting and managing medication efficacy, side effects, and toxicity of drugs based on individual genetic variability of crew members are increasingly needed. In this report, we present results of testing the market available Personalized Prescribing System (PPS), a comprehensive, non-invasive solution for safer, targeted medication management for every crew member. Statistical accuracy and simplicity of non-invasive sample analysis demonstrate the feasibility of drug sensitivity assessment and record-keeping tool for flight surgeons and astronauts in applying the recommended medications for situations arising in flight. The information on individual drug sensitivity will translate into personalized risk assessment for adverse drug reactions and treatment failures for each drug from the medication kit as well as predefined outcome. This will address the HHC’s raised “Concern of Clinically Relevant Unpredicted Effects of Medication” as recently updated.

medications↗

NASA NTRS2011

The Effect of Predicted Vehicle Displacement on Ground Crew Task Performance and Hardware Design

NASA continues to explore new launch vehicle concepts that will carry astronauts to low- Earth orbit to replace the soon-to-be retired Space Transportation System (STS) shuttle. A tall vertically stacked launch vehicle (> or =300 ft) is exposed to the natural environment while positioned on the launch pad. Varying directional winds and vortex shedding cause the vehicle to sway in an oscillating motion. Ground crews working high on the tower and inside the vehicle during launch preparations will be subjected to this motion while conducting critical closeout tasks such as mating fluid and electrical connectors and carrying heavy objects. NASA has not experienced performing these tasks in such environments since the Saturn V, which was serviced from a movable (but rigid) service structure; commercial launchers are likewise attended by a service structure that moves away from the vehicle for launch. There is concern that vehicle displacement may hinder ground crew operations, impact the ground system designs, and ultimately affect launch availability. The vehicle sway assessment objective is to replicate predicted frequencies and displacements of these tall vehicles, examine typical ground crew tasks, and provide insight into potential vehicle design considerations and ground crew performance guidelines. This paper outlines the methodology, configurations, and motion testing performed while conducting the vehicle displacement assessment that will be used as a Technical Memorandum for future vertically stacked vehicle designs.

Atencio, Laura Ashley↗