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At least 1,549 records · Page 86

Angiogenic Blockade and Radiotherapy in Hepatocellular Carcinoma

Purpose: We report our preliminary experience of combining sunitinib and helical tomotherapy in patients with advanced HCC. Methods and Materials: Records of patients with advanced hepatocellular carcinoma (HCC) treated with helical tomotherapy and sunitinib after radiation therapy (RT) from March 2007 to August 2008 were retrospectively reviewed. We report acute toxicities, radiologic response, serial {alpha}-fetoprotein (AFP) kinetics, and survival. Results: Of 23 evaluable patients, 60% had {>=}2 hepatic lesions, extrahepatic disease was present in 5 (21.7%), and all received 2 tablets (25 mg) of sunitinib at least 1 week before, during, and 2 weeks after RT. Thirteen patients continued maintenance sunitinib after RT until disease progression. Hypofractionated RT with a median target dose of 52.5 Gy/15 fractions was delivered. An objective response was achieved in 74% of patients. The 1-year survival rate was 70%, with median survival of 16 months. Multivariate analysis showed that maintenance sunitinib was the most significant factor for survival. The time to progression was 10 months in the maintenance group compared with 4 months in the control group. Eighteen out of 21 patients with elevated AFP (85.7%) had {>=}50% decline of AFP within 2 months after RT. There were three episodes of upper gastrointestinal bleeding and one episode of pancreatitis; 10 patients had {>=}Grade 2 elevation of liver enzymes, and 15 had {>=}Grade 2 thrombocytopenia. Conclusions: These preliminary results suggest that sunitinib and helical tomotherapy yield high Response Evaluation Criteria in Solid Tumors (RECIST) and AFP response rates in advanced HCC with an acceptable safety profile. Maintenance sunitinib after RT potentially prolongs survival. A randomized trial is warranted.

62 RADIOLOGY AND NUCLEAR MEDICINE↗

Economics of new molecular targeted personalized radiopharmaceuticals

We report that Nuclear Medicine has come a long way since 2007 when Adrian Nunn pointed out the approval of radiopharmaceuticals was at an all-time low with all the major radiopharmaceutical agents in use having been approved over 10 years ago. Challenges being the prohibitively high cost of drug development and the large number of drugs failing in clinical trials. Proceed to today where Molecular imaging is fast-tracking the drug discovery process by reducing both the time and cost to screen candidates by quantitating the drugs effect on the target and toxicity to normal tissues. Additionally, nuclear medicine is now leading medical practice in personalized medicine using the theragnostic approach. Theragnostics is defined as the use of molecular diagnostic techniques in real-time to stratify patients to guide treatment decisions such as the choice of drug, the dose of administration and the timing of drug delivery for a given patient. Enabling visualization and quantitation of in vivo function of the whole body and thus patient heterogeneity and variability informs the physician on how to treat an individual patient. Recent successes such as the FDA approval of Luta Thera® and NETSPOT™ have resulted in an increasing number of pharmaceutical companies pursing theragnostics further heightened by the purchase of Advanced Accelerator Applications for 3.9 billion by Novartis and Endocyte, Inc for 2.1 billion. Theragnostics are further aiding drug development by showing which agents are most viable and reducing the overall cost of bringing a drug to clinical trials and regulatory approval. This is indeed a renaissance for nuclear medicine in which the acceptance of imaging to inform and monitor therapy has been embraced and even required by the FDA for the clinical evaluation of targeted therapeutic radiopharmaceuticals showing there is indeed a viable business model for targeted theragnostic radiopharmaceuticals and personalized medicine.

62 RADIOLOGY AND NUCLEAR MEDICINE↗

MURMoT. Design and Application of Microbial Uranium Reduction Monitoring Tools

Uranium (U) contamination in the subsurface is a major remediation challenge at many DOE sites. Traditional site remedies present enormous costs to DOE; hence, enhanced bioremediation technologies (i.e., biostimulation and bioaugmentation) combined with monitoring efforts are being considered as cost-effective corrective actions to address subsurface contamination. This research effort improved understanding of the microbial U reduction process and developed new tools for monitoring microbial activities. Application of these tools will promote science-based site management decisions that achieve contaminant detoxification, plume control, and long-term stewardship in the most efficient manner. The overarching hypothesis was that the design, validation and application of a suite of new molecular and biogeochemical tools advance process understanding, and improve environmental monitoring regimes to assess and predict in situ U immobilization. Accomplishments: This project (i) advanced nucleic acid-based approaches to elucidate the presence, abundance, dynamics, spatial distribution, and activity of metal- and radionuclide-detoxifying bacteria; (ii) developed proteomics workflows for detection of metal reduction biomarker proteins in laboratory cultures and contaminated site groundwater; (iii) developed and demonstrated the utility of U isotopic fractionation using high precision mass spectrometry to quantify U(VI) reduction for a range of reduction mechanisms and environmental conditions; and (iv) validated the new tools using field samples from U-contaminated IFRC sites, and demonstrated their prognostic and diagnostic capabilities in guiding decision making for environmental remediation and long-term site stewardship.

54 ENVIRONMENTAL SCIENCES↗

Conceptual design of liquid droplet radiator shuttle-attached experiment

The conceptual design of a shuttle-attached liquid droplet radiator (LDR) experiment is discussed. The LDR is an advanced, lightweight heat rejection concept that can be used to reject heat from future high-powered space platforms. In the LDR concept, submillimeter-sized droplets are generated, pass through space, radiate heat before they are collected, and recirculated back to the heat source. The LDR experiment is designed to be attached to the shuttle longeron and integrated into the shuttle bay using standard shuttle/experiment interfaces. Overall power, weight, and data requirements of the experiment are detailed. The conceptual designs of the droplet radiator, droplet collector, and the optical diagnostic system are discussed in detail. Shuttle integration and safety design issues are also discussed.

Pfeiffer, Shlomo L.↗

A need to reduce premature CV mortality in the developing world: How could appropriate use of non-invasive imaging help?

We discuss premature deaths due to coronary heart disease (CHD) in developing countries and the importance of a comprehensive approach, involving clinical judgement, prevention, appropriate use of technology to diagnose and guide CHD treatment. Healthcare policies and levels of knowledge vary tremendously resulting heterogeneous utilization of diagnostic strategies and treatments worldwide. Many countries with high mortality have low utilization of non-invasive cardiac imaging. Appropriate use coupled with guideline-based management could help to improve care in the developing world and potentially result in better life expectancy already experienced by most high-income countries. In a scenario of increasing costs, a rational utilization of resources is imperative for all nations. A stepwise approach to suspected CHD is necessary, starting from good judgement, adding tests only as needed, preferably filtering patients who might benefit from advanced imaging. In stable patients, non-invasive tests should be used as filters to invasive procedure, preventing stable patients from undergoing revascularizations of questionable benefit. In this article, we review the relative role of exercise testing, myocardial perfusion imaging, and coronary computed tomography angiography to evaluate CHD and how these can be utilized as ways to help guide management that could impact premature mortality in developing nations.

62 RADIOLOGY AND NUCLEAR MEDICINE↗

Spectrometer for shot-to-shot photon energy characterization in the multi-bunch mode of the free electron laser at Hamburg

The setup and first results from commissioning of a fast online photon energy spectrometer for the vacuum ultraviolet free electron laser at Hamburg (FLASH) at DESY are presented. With the use of the latest advances in detector development, the presented spectrometer reaches readout frequencies up to 1 MHz. In this paper, we demonstrate the ability to record online photon energy spectra on a shot-to-shot base in the multi-bunch mode of FLASH. Clearly resolved shifts in the mean wavelength over the pulse train as well as shot-to-shot wavelength fluctuations arising from the statistical nature of the photon generating self-amplified spontaneous emission process have been observed. In addition to an online tool for beam calibration and photon diagnostics, the spectrometer enables the determination and selection of spectral data taken with a transparent experiment up front over the photon energy of every shot. This leads to higher spectral resolutions without the loss of efficiency or photon flux by using single-bunch mode or monochromators.

46 INSTRUMENTATION RELATED TO NUCLEAR SCIENCE AND ↗

CalWater Field Studies Designed to Quantify the Roles of Atmospheric Rivers and Aerosols in Modulating U.S. West Coast Precipitation in a Changing Climate

The variability of precipitation and water supply along the U.S. West Coast creates major challenges to the region’s economy and environment, as evidenced by the recent California drought. This variability is strongly influenced by atmospheric rivers (AR), which deliver much of the precipitation along the U.S. West Coast and can cause flooding, and by aerosols (from local sources and transported from remote continents and oceans) that modulate clouds and precipitation. A better understanding of these processes is needed to reduce uncertainties in weather predictions and climate projections of droughts and floods, both now and under changing climate conditions.To address these gaps a group of meteorologists, hydrologists, climate scientists, atmospheric chemists, and oceanographers have created an interdisciplinary research effort, with support from multiple agencies. From 2009-2011 a series of field campaigns (CalWater 1) collected atmospheric chemistry, cloud microphysics and meteorological measurements in California and associated modeling and diagnostic studies were carried out. Based on remaining gaps, a vision was developed to extend these studies offshore over the Eastern North Pacific and to enhance land based measurements from 2014-2018 (CalWater 2). The data set and selected results from CalWater 1 are summarized here. The goals of CalWater-2, and measurements to date, are then described. Through this work, CalWater is producing new findings and exploring new technologies to evaluate and improve global climate models and their regional performance and to develop tools supporting water and hydropower management. These advances also have potential to enhance hazard mitigation by improving near-term weather prediction and subseasonal and seasonal outlooks.

54 ENVIRONMENTAL SCIENCES↗

High Temperature, High Pressure Devices for Zonal Isolation in Geothermal Wells

The U.S. Department of Energy is leading the development of alternative energy sources that will ensure the long-term energy independence of our nation. One key renewable resource being advanced is geothermal energy which offers an environmentally benign, reliable source of energy for the nation. To utilize this resource, water will be introduced into wells 3 to 10 km deep to create a geothermal reservoir. This approach is known as an Enhanced Geothermal System (EGS). The high temperatures and pressures at these depths have become a limiting factor in the development of this energy source. For example, reliable zonal isolation for high-temperature applications at high differential pressures is needed to conduct mini-fracs and other stress state diagnostics. Zonal isolation is essential for many EGS reservoir development activities. To date, the capability has not been sufficiently demonstrated to isolate sections of the wellbore to: 1) enable stimulation; and 2) seal off unwanted flow regions in unknown EGS completion schemes and high-temperature (>200°C) environments. In addition, packers and other zonal isolation tools are required to eliminate fluid loss, to help identify and mitigate short circuiting of flow from injectors to producers, and to target individual fractures or fracture networks for testing and validating reservoir models. General-purpose open-hole packers do not exist for geothermal environments, with the primary barrier being the poor stability of elastomeric seals at high temperature above 175°C. Experimental packer systems have been developed for geothermal environments but they currently only operate at low pressure, they are not retrievable, and they are not commercially available. The development of the high-temperature, high-pressure (HTHP) zonal isolation device would provide the geothermal community with the capability to conduct mini-fracs, eliminate fluid loss, to help identify and mitigate short circuiting of flow from injectors to producers, and to target individual fractures or fracture networks for testing and validating reservoir models. The goal of this program, therefore, was to develop and demonstrate reliable high-temperature high-pressure zonal isolation devices that are compatible with the high-temperature downhole environment anticipated for Enhanced Geothermal Systems. Over the course of this 3 year program, CTD designed and demonstrated a high temperature high pressure zonal isolation device. CTD has utilized its expertise in high-temperature materials, shape memory composites and foams, and deployment mechanisms for spacecraft and oil tools to develop a new class of HTHP zonal isolation devices for use in EGS. Specifically, the objective was to demonstrate the ability to isolate sections of an EGS wellbore to: 1) enable stimulation; and 2) seal off unwanted flow regions in unknown EGS completion schemes and high-temperature (>200°C) environments at temperatures upwards of 300°C. A concept for a high-temperature, high-pressure zonal isolation device was designed for use in creating circulation paths in environments where temperatures are in excess of 300°C and differential pressures of up to 10,000 psi are required to stimulate solid granite. This new zonal isolation device distributes the high-pressure differential through a significant length of high temperature, shape memory polymer composite material. The development of differential pressure is initiated by a thermally triggered actuation of a ‘structural seal’ that fills the cross section of the bore with the shape memory material. After this preliminary seal is made, differential pressure begins to build through the material as the seal forces the flow to pass through pores in the shape memory material. The shape memory material is compressed into place to react the force of the internal

58 GEOSCIENCES↗

Diagnostics and Models for Birthing Stress

Understanding the stress development in fluids as they transition to solids is not well-understood. Computational models are needed to represent "birthing stress" for multiphysics applications such as polymer encapsulation around sensitive electronics and additive manufacturing where these stresses can lead to defects such as cracking and voids. The local stress state is also critical to understand and predict the net shape of parts formed in the liquid phase. In this one-year exploratory LDRD, we have worked towards a novel experimental diagnostic to measure the fluid rheology, degree of solidification, and the solid stress development simultaneously. We debugged and made viable a "first-generation" Rheo-Raman system and used it to characterize two types of solidifying systems: paraffin wax, which crystalizes as it solidifies, and thermoset polymers, which form a network of covalent bonds. We used the paraffin wax as a model system to perform flow visualization studies and did some preliminary modeling of the experiment, to demonstrate the inadequacy of the current modeling approaches. This work will inform an advanced fluid constitutive equation that includes a yield stress, temperature dependence, and an evolving viscosity when we pursue the full proposal, which was funded for FY20.

36 MATERIALS SCIENCE↗

Future Issues and Approaches to Health Monitoring and Failure Prevention for Oil-Free Gas Turbines

Recent technology advances in foil air bearings, high temperature solid lubricants and computer based modeling has enabled the development of small Oil-Free gas turbines. These turbomachines are currently commercialized as small (<100 kW) microturbine generators and larger machines are being developed. Based upon these successes and the high potential payoffs offered by Oil-Free systems, NASA, industry, and other government entities are anticipating Oil-Free gas turbine propulsion systems to proliferate future markets. Since an Oil-Free engine has no oil system, traditional approaches to health monitoring and diagnostics, such as chip detection, oil analysis, and possibly vibration signature analyses (e.g., ball pass frequency) will be unavailable. As such, new approaches will need to be considered. These could include shaft orbit analyses, foil bearing temperature measurements, embedded wear sensors and start-up/coast down speed analysis. In addition, novel, as yet undeveloped techniques may emerge based upon concurrent developments in MEMS technology. This paper introduces Oil-Free technology, reviews the current state of the art and potential for future turbomachinery applications and discusses possible approaches to health monitoring, diagnostics and failure prevention.

DellaCorte, Christopher↗

Embedded Data Acquisition Tools for Rotorcraft Diagnostic Sensors

Rotorcraft drive trains must withstand enormous pressure while operating continuously in extreme temperature and vibration environments. Captive components, such as planetary and spiral bevel gears, see enormous strain but are not accessible to fixed instrumentation, such as a piezoelectric transducer. Thus, it is difficult to directly monitor components that are most susceptible to damage. This innovation is a self-contained data processing unit within a specialized fixture that installs directly inside the rotating pinion gear in the gearbox. From this location, it detects and transmits high-resolution prognostic data to a fixed transceiver. The sensor is based on microelectromechanical systems (MEMS) technology and uses innovative circuit designs to capture high-bandwidth data and transmit it wirelessly from inside an operational helicopter transmission. With Ridgetop's advanced MEMS-based sensor, researchers have, for the first time, been able to extract high-resolution acoustic signatures wirelessly from sensors within the transmission that would otherwise be muffled by background gear noises. Ridgetop's innovative instrument will help researchers perform dynamic analysis of gear interaction and develop improved designs for gear components. In addition, data from this instrument can be used to validate new algorithms that detect and predict faults based on external acoustic signatures, for prognostic purposes. The result of this work will be an improvement in safety, performance, and cost for future generations of rotating components.

Wagoner, Robert↗

Overview of NASA's Solar Electric Propulsion Project

NASA is continuing to develop and qualify a state of the art 13 kW-class Advanced Electric Propulsion System (AEPS) for NASA exploration missions through a contract with Aerojet Rocketdyne (AR). An objective of the AEPS project is accelerate the adoption of high power electric propulsion technologies by reducing the risk and uncertainty of integrating Solar Electric Propulsion (SEP) technologies into space flight systems. NASA and AR have recently initiated testing of engineering hardware including the Hall Current Thruster (HCT), Power Processing Unit (PPU), and Xenon Flow Controller (XFC) at both the component and system levels. The successful completion of these tests will provide the required information to advance the AEPS system towards Critical Design Review. In support of the AEPS contract, NASA and JPL have been performing risk reduction activities to address specific concerns of this higher power Hall thruster propulsion system. These risk reduction activities have included long duration wear testing of the Technology Demonstration Unit (TDU) Hall thruster and cathode hardware, thermal cycling of TDU cathode heaters and coils, plasma plume measurements, and performed early circuit testing of the AEPS PPU design. In addition to the propulsion system development, the SEP project is developing the Plasma Diagnostic Package (PDP) and the SEP Testbed. The PDP is designed for use in conjunction with a high-powered electric propulsion (EP) system to characterize in-space operation. The SEP Testbed system is being developed to demonstrate integrated SEP system performance. The paper presents an overview of the NASA and the AEPS contract activities and a summary of the associated NASA in-house activities.

Plasma diagnostics package↗

Curation of Ground-Truth Validated Benchmarking Datasets for Fault Detection & Diagnostics Tools

Fault detection and diagnostics (FDD) analytical tools for heating, ventilation and air conditioning (HVAC) systems represent one of the most active areas of smart building technology development. A diversity of techniques is used for FDD analytics, spanning physical models, black box, and rule-based approaches, and researchers continuously strive to develop improved algorithms. With FDD algorithm numbers now in the hundreds, there is a need for performance evaluation of these algorithms in order to assess improvements, improve costeffectiveness, and to prioritize investment in the further development of these technologies. A persistent challenge of FDD advance has been the lack of common datasets to benchmark the performance accuracy of FDD algorithms. This paper summarizes the successful curation of HVAC operational data, paired with validated ground-truth information regarding the presence and absence of faults. The current dataset, consisting of both simulation and experimental data, will evolve to include a larger set of HVAC systems with the objective of creating the largest publicly available dataset to be used by FDD developers, users, and researchers to compare and contrast performance accuracy across FDD algorithms, helping to drive improvements that will spur greater market adoption of FDD tools. Furthermore, in order to avoid previously observed issues with contributed datasets and ensure high quality and consistency of future submissions, the development of data validation and ground-truth assessment protocol is detailed in this study.

Casillas, Armando↗

Polycyclic Aromatic Hydrocarbons and Astrophysics: The State of the Pah Model and a Possible Tracer of Nitrogen in Carbon-Rich Dust

Over the past fifteen years, thanks to significant, parallel advancements in observational, experimental, and theoretical techniques, tremendous strides have been made in our understanding of the role aromatic materials play in the interstellar medium (ISM). Twenty years ago, the possible existence of an abundant population of large, carbon-rich molecules in the ISM was unthinkable. Today, the unmistakable spectroscopic signatures of polycyclic aromatic hydrocarbon molecules (PAHs) - shockingly large molecules by the standards of traditional interstellar chemistry - are recognized throughout the Universe. In this paper, we will examine the current state of the interstellar PAH model and its utility as a diagnostic tool to derive insight into the nature of the interstellar PAH population. As an example of this application, we will examine the results of our recent spectroscopic studies of polycyclic aromatic nitrogen heterocycles (PANHs)-PAHs with an atom of nitrogen substituted into the aromatic skeleton-and discuss a possible tracer of such species amongst the interstellar PAH emission bands in the latest observational data.

Hudgins, Douglas M.↗

The upgraded scheme of Hefei Light Source

To enhance the performance of Hefei Light Source, which was designed and constructed two decades ago, an upgrade project would be carried out in the near future. The detail upgrade scheme was described in this paper. Firstly, the magnet lattice of storage ring should be reconstructed with 4 DBA cells, whose advantages are lower beam emittance and more straight section available for insertion devices. Secondly, the beam diagnostics, main power supply, transverse and longitudinal multi-bunch feedback, beam control and manipulation system would be upgrade to improve the beam orbit stability. Finally, the injection system of storage ring and injector, which is composed of electron linac and beam transfer line, would be updated in order to assure smooth beam accumulation process under new low emittance lattice. With above improvement, it is hopeful to increase the brilliance of Hefei Light Source by two orders approximately. After three-year upgrade project, the performance of HLS would meet the demands of advanced SR users.

43 PARTICLE ACCELERATORS↗

IDAES-PSE 2.3.0 Release

The Institute for the Design of Advanced Energy Systems (IDAES) Integrated Platform is a versatile computational environment offering extensive process systems engineering (PSE) capabilities for optimizing the design and operation of complex, interacting technologies and systems. IDAES enables users to efficiently search vast, complex design spaces to discover the lowest cost, most environmentally sustainable solutions while supporting the full process modeling lifecycle, from conceptual design to dynamic optimization and control. The extensible, open platform empowers users to create models of novel processes and rapidly develop custom analyses, workflows, and end-user applications.. New Features and Models • New diagnostics toolboxes and examples o Tutorial for using the DiagnosticsToolbox o Methods to identify potential evaluation errors in models o SVDToolbox for performing singular value decomposition analysis on models to identify possible degeneracies and poor scaling o DegeneracyHunter for identifying irreducible degenerate sets in models • Model for solid-liquid separation which takes two inputs (solid and liquid streams) and produces three outlets (solids, liquid entrained with solids and pure liquid) • Example of temperature swing adsorption in models_extra Deprecation Warnings • With the update to Pyomo 6.7.0, the plate heat exchanger model has begun failing tests on some CI platforms. If this is not addressed by the February release, this model may be removed due to failing tests. See #1294. Offers to help identify the cause and fix this issue are welcome. Improvements and bug fixes • Fixed oversight which precluded using Mixer and Separator models when inherent reactions were present in property package • Added reporting methods to the MSContactor model • Minor corrections in some examples where values were being fixed outside of declared variable bounds

DiagnosticsToolbox,IDAES,PSE,Process Systems Engin↗

Quantification of PET Myocardial Blood Flow

Purpose of Review: The aim of this review is to provide an update on quantification of myocardial blood flow (MBF) with positron emission tomography (PET) imaging. Technical and clinical aspects of flow quantification with PET are reviewed. Recent Findings: The diagnostic and prognostic values of myocardial flow quantification have been established in numerous studies and in various populations. MBF quantification has also shown itself to be particularly useful in the assessment of coronary microvascular dysfunction and in evaluation of cardiac allograft vasculopathy. Overall, myocardial flow reserve (MFR) and hyperemic MBF can lead to improved risk stratification by providing information complementary to that of other markers of disease severity, such as fractional flow reserve. Summary: Flow quantification enhances MPI’s ability to detect both significant epicardial disease and microvascular dysfunction. With recent technological and methodological advances, flow quantification with PET is no longer restricted to cyclotron-equipped academic centers.

62 RADIOLOGY AND NUCLEAR MEDICINE↗

Reversible Electron Beam Heating for Suppression of Microbunching Instabilities at Free-Electron Lasers

The presence of microbunching instabilities due to the compression of high-brightness electron beams at existing and future x-ray free-electron lasers (FELs) results in restrictions on the attainable lasing performance and renders beam imaging with optical transition radiation impossible. The instability can be suppressed by introducing additional energy spread, i.e., heating the electron beam, as demonstrated by the successful operation of the laser heater system at the Linac Coherent Light Source. The increased energy spread is typically tolerable for self-amplified spontaneous emission FELs but limits the effectiveness of advanced FEL schemes such as seeding. In this paper, we present a reversible electron beam heating system based on two transverse deflecting radio-frequency structures (TDSs) upstream and downstream of a magnetic bunch compressor chicane. The additional energy spread is introduced in the first TDS, which suppresses the microbunching instability, and then is eliminated in the second TDS. We show the feasibility of the microbunching gain suppression based on calculations and simulations including the effects of coherent synchrotron radiation. Acceptable electron beam and radio-frequency jitter are identified, and inherent options for diagnostics and on-line monitoring of the electron beam's longitudinal phase space are discussed.

43 PARTICLE ACCELERATORS↗