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Search indexed NASA NTRS and DOE OSTI research on propulsion, heat transfer, battery materials and energy systems. Follow report and document links to the original sources.

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At least 1,513 records · Page 84
All sourcesNASA NTRSDOE OSTI
NASA NTRS1998

Noninvasive measurement of pulsatile intracranial pressure using ultrasound

The present study was designed to validate our noninvasive ultrasonic technique (pulse phase locked loop: PPLL) for measuring intracranial pressure (ICP) waveforms. The technique is based upon detecting skull movements which are known to occur in conjunction with altered intracranial pressure. In bench model studies, PPLL output was highly correlated with changes in the distance between a transducer and a reflecting target (R2 = 0.977). In cadaver studies, transcranial distance was measured while pulsations of ICP (amplitudes of zero to 10 mmHg) were generated by rhythmic injections of saline. Frequency analyses (fast Fourier transformation) clearly demonstrate the correspondence between the PPLL output and ICP pulse cycles. Although theoretically there is a slight possibility that changes in the PPLL output are caused by changes in the ultrasonic velocity of brain tissue, the decreased amplitudes of the PPLL output as the external compression of the head was increased indicates that the PPLL output represents substantial skull movement associated with altered ICP. In conclusion, the ultrasound device has sufficient sensitivity to detect transcranial pulsations which occur in association with the cardiac cycle. Our technique makes it possible to analyze ICP waveforms noninvasively and will be helpful for understanding intracranial compliance and cerebrovascular circulation.

NASA Center ARC↗
NASA NTRS2012

Hyperspectral Feature Detection Onboard the Earth Observing One Spacecraft using Superpixel Segmentation and Endmember Extraction

We present a demonstration of onboard hyperspectral image processing with the potential to reduce mission downlink requirements. The system detects spectral endmembers and then uses them to map units of surface material. This summarizes the content of the scene, reveals spectral anomalies warranting fast response, and reduces data volume by two orders of magnitude. We have integrated this system into the Autonomous Science craft Experiment for operational use onboard the Earth Observing One (EO-1) Spacecraft. The system does not require prior knowledge about spectra of interest. We report on a series of trial overflights in which identical spacecraft commands are effective for autonomous spectral discovery and mapping for varied target features, scenes and imaging conditions.

Superpixel Endmember Detection↗
DOE OSTI2025

A hidden cysteine in Fis1 targeted to prevent excessive mitochondrial fission and dysfunction under oxidative stress

Fis1-mediated mitochondrial localization of Drp1 and excessive mitochondrial fission occur in human pathologies associated with oxidative stress. However, it is not known how Fis1 detects oxidative stress and what structural changes in Fis1 enable mitochondrial recruitment of Drp1. We find that conformational change involving α1 helix in Fis1 exposes its only cysteine, Cys41. In the presence of oxidative stress, the exposed Cys41 in activated Fis1 forms a disulfide bridge and the Fis1 covalent homodimers cause increased mitochondrial fission through increased Drp1 recruitment to mitochondria. Our discovery of a small molecule, SP11, that binds only to activated Fis1 by engaging Cys41, and data from genetically engineered cell lines lacking Cys41 strongly suggest a role of Fis1 homodimerization in Drp1 recruitment to mitochondria and excessive mitochondrial fission. The structure of activated Fis1-SP11 complex further confirms these insights related to Cys41 being the sensor for oxidative stress. Importantly, SP11 preserves mitochondrial integrity and function in cells during oxidative stress and thus may serve as a candidate molecule for the development of treatment for diseases with underlying Fis1-mediated mitochondrial fragmentation and dysfunction.

59 BASIC BIOLOGICAL SCIENCES↗
DOE OSTI2022

CMB-S4: Forecasting Constraints on Primordial Gravitational Waves

CMB-S4—the next-generation ground-based cosmic microwave background (CMB) experiment—is set to significantly advance the sensitivity of CMB measurements and enhance our understanding of the origin and evolution of the universe. Among the science cases pursued with CMB-S4, the quest for detecting primordial gravitational waves is a central driver of the experimental design. This work details the development of a forecasting framework that includes a power-spectrum-based semianalytic projection tool, targeted explicitly toward optimizing constraints on the tensor-to-scalar ratio, r, in the presence of Galactic foregrounds and gravitational lensing of the CMB. This framework is unique in its direct use of information from the achieved performance of current Stage 2–3 CMB experiments to robustly forecast the science reach of upcoming CMB-polarization endeavors. The methodology allows for rapid iteration over experimental configurations and offers a flexible way to optimize the design of future experiments, given a desired scientific goal. To form a closed-loop process, we couple this semianalytic tool with map-based validation studies, which allow for the injection of additional complexity and verification of our forecasts with several independent analysis methods. We document multiple rounds of forecasts for CMB-S4 using this process and the resulting establishment of the current reference design of the primordial gravitational-wave component of the Stage-4 experiment, optimized to achieve our science goals of detecting primordial gravitational waves for r > 0.003 at greater than 5σ, or in the absence of a detection, of reaching an upper limit of r < 0.001 at 95% CL.

79 ASTRONOMY AND ASTROPHYSICS↗
DOE OSTI2020

The CLAS12 Backward Angle Neutron Detector (BAND)

The Backward Angle Neutron Detector (BAND) of CLAS12 detects neutrons emitted at backward angles of 155° to 175°, with momenta between 200 and 600 MeV$/c_0$. It is positioned 3-m upstream of the target, consists of 18 rows and 5 layers of 7.2-cm by 7.2-cm scintillator bars, and read out on both ends by PMTs to measure time and energy deposition in the scintillator layers. Between the target and BAND there is a 2-cm thick lead wall followed by a 2-cm veto layer to suppress gammas and reject charged particles. This paper discusses the component-selection tests and the detector assembly. Timing calibrations (including offsets and time-walk) were performed using a novel pulsed-laser calibration system, resulting in time resolutions better than 250 ps (150 ps) for energy depositions above 2 MeV (5 MeV). Cosmic rays and a variety of radioactive sources were used to calibration the energy response of the detector. Scintillator bar attenuation lengths were measured. We report the time resolution results in a neutron momentum reconstruction resolution, $δp/p$ < 1.5% for neutron momentum 200 ≤ $p$ ≤ 600 MeV/c. Final performance of the BAND with CLAS12 is shown, including electron–neutral particle timing spectra and a discussion of the off-time neutral contamination as a function of energy deposition threshold.

46 INSTRUMENTATION RELATED TO NUCLEAR SCIENCE AND ↗
DOE OSTI2025

Cross sections of 147–149 Sm( 6 Li,x) reactions for the production of 149 Tb for targeted alpha therapy

Terbium-149g (t 1/2 = 4.12 h) is of particular interest for targeted alpha therapy cancer treatment due to its ability to decay via both alpha and positron emission, making it a potential theranostic nuclide. Due to many challenges facing its production, there are limited facilities worldwide that have demonstrated the ability to produce this nuclide in quantities sufficient for medical research. Since the Cyclotron Institute at Texas A&M University is a specialized accelerator facility capable of accelerating a wide variety of ions, we are investigating production pathway options. One of the major challenges facing its production is the known co-production of the excited isomeric state, 149m Tb (t 1/2 = 4.1 min). However, this state does not decay to the ground state of 149g Tb, negating any potential contribution to its yield. Due to its short-half life, the cross section for the population of this state has never been measured. After calculating several potential reaction yields using predictive models, the reactions of 147–149 Sm( 6 Li,xn) 149 Tb were identified as candidates. Lithium-6 beams of varied energies between 45-65 MeV were impinged on enriched 147 Sm, 148 Sm, and 149 Sm targets at the Cyclotron Institute at Texas A&M University, and the reaction products were measured immediately following irradiation using high-purity germanium detectors, enabling detection of both 149m Tb and 149g Tb. Cross sections for all nuclides produced in sufficient activity in these reactions were also measured and reported here. We conclude that the population of 149m Tb is much preferred over population of the ground state for these 6 Li-induced reactions, and it is necessary to explore other options for 149g Tb production.

62 RADIOLOGY AND NUCLEAR MEDICINE↗
DOE OSTI2020

Verification of Arms Control Treaties with Resonance Phenomena

Nuclear disarmament treaties remain insufficient to neutralize the existential threat of the nuclear weapons. Technologies are necessary for verifying the authenticity of the nuclear warheads undergoing dismantlement before counting them toward a treaty partner’s obligation. Here we present a review of concepts involving isotope-specific resonance processes, Nuclear Resonance Fluorescence (NRF) [1] and Neutron Resonance Transmission Analysis (NRTA) [2, 3], used to authenticate a warhead’s fissile components by comparing them to a previously authenticated template. All information is encrypted in the physical domain by the addition of an encrypting filter to the target, leading to measurements with an outcome similar to an equation with two unknowns. Using Monte Carlo simulations and experiments we show that the measurements readily detect hoaxing attempt, while no vital isotopic or geometric information about the weapon is released. These nuclear techniques can be used to dramatically increase the reach and trustworthiness of future nuclear disarmament treaties.

98 NUCLEAR DISARMAMENT, SAFEGUARDS, AND PHYSICAL P↗
DOE OSTI2023

Identification of blood protein biomarkers associated with prostate cancer risk using genetic prediction models: analysis of over 140,000 subjects

Prostate cancer (PCa) brings huge public health burden in men. A growing number of conventional observational studies report associations of multiple circulating proteins with PCa risk. However, the existing findings may be subject to incoherent biases of conventional epidemiologic studies. To better characterize their associations, herein, we evaluated associations of genetically predicted concentrations of plasma proteins with PCa risk. In this study, we developed comprehensive genetic prediction models for protein levels in plasma. After testing 1308 proteins in 79 194 cases and 61 112 controls of European ancestry included in the consortia of BPC3, CAPS, CRUK, PEGASUS, and PRACTICAL, 24 proteins showed significant associations with PCa risk, including 16 previously reported proteins and eight novel proteins. Of them, 14 proteins showed negative associations and 10 showed positive associations with PCa risk. For 18 of the identified proteins, potential functional somatic changes of encoding genes were detected in PCa patients in The Cancer Genome Atlas (TCGA). Genes encoding these proteins were significantly involved in cancer-related pathways. We further identified drugs targeting the identified proteins, which may serve as candidates for drug repurposing for treating PCa. In conclusion, this study identifies novel protein biomarker candidates for PCa risk, which may provide new perspectives on the etiology of PCa and improve its therapeutic strategies.

59 BASIC BIOLOGICAL SCIENCES↗
DOE OSTI2025

First Search for Axion Dark Matter with a MADMAX Prototype

This Letter presents the first search for dark matter axions with mass in the ranges 76.56 to 76.82 μ⁢eV and 79.31 to 79.53 μ⁢eV using a prototype setup for the MAgnetized Disk and Mirror Axion eXperiment (MADMAX). The experimental setup employs a dielectric haloscope consisting of three sapphire disks and a mirror to resonantly enhance the axion-induced microwave signal within the magnetic dipole field provided by the 1.6 T Morpurgo magnet at CERN. Over 14.5 days of data collection, no axion signal was detected. A 95% CL upper limit on the axion-photon coupling strength down to |𝑔 𝑎⁢𝛾 |∼2×10 −11 GeV −1 is set in the targeted mass ranges, surpassing previous constraints, assuming a local axion dark matter density 𝜌 𝑎 of 0.3 GeV/cm 3 . This study marks the first axion dark matter search using a dielectric haloscope.

72 PHYSICS OF ELEMENTARY PARTICLES AND FIELDS↗
DOE OSTI2023

Seismoacoustic Signatures Observed During a Long-Term Deployment of Infrasound Sensors at the Nevada National Security Site

Earthquakes have repeatedly been shown to produce inaudible acoustic signals (<20 Hz), otherwise known as infrasound. These signals can propagate hundreds to thousands of kilometers and still be detected by ground-based infrasound arrays depending on the source strength, distance between source and receiver, and atmospheric conditions. Another type of signal arrival at infrasound arrays is the seismic induced motion of the sensor itself, or ground-motion-induced sensor noise. Measured acoustic and seismic waves produced by earthquakes can provide insight into properties of the earthquake such as magnitude, depth, and focal mechanism, as well as information about the local lithology and atmospheric conditions. Large earthquakes that produce strong acoustic signals detected at distances greater than 100 km are the most commonly studied; however, more recent studies have found that smaller magnitude earthquakes ($M$ w <2.0) can be detected at short ranges. In that vein, this study will investigate the ability for a long-term deployment of infrasound sensors (deployed as part of the Source Physics Experiments [SPE] from 2014 to 2020) to detect both seismic and infrasonic signals from earthquakes at local ranges (<50 km). Methods used include a combination of spectral analysis and automated array processing, supported by U.S. Geological Survey earthquake bulletins. Further, this investigation revealed no clear acoustic detections for short range earthquakes. However, secondary infrasound from an $M$ w 7.1 earthquake over 200 km away was detected. Important insights were also made regarding the performance of the SPE networks including detections of other acoustic sources such as bolides and rocket launches. Finally, evaluation of the infrasound arrays is performed to provide insight into optimal deployments for targeting earthquake infrasound.

58 GEOSCIENCES↗
DOE OSTI2026

Measurement of charged-current quasi elastic-like and inclusive muon (anti-) neutrino interactions using NuMI beam the ICARUS detector

The ICARUS experiment, utilizing Liquid Argon Time Projection Chamber (LArTPC) technology, has been successfully taking physics data at Fermilab since June 2022. The experiment's primary objective is to function as the far detector of the Short Baseline Neutrino program (SBN), searching for hints of physics beyond three-flavour PMNS neutrino oscillations. ICARUS also offers other diverse physics capabilities, including searches beyond the standard model and measurements of cross-sections. In addition to being exposed to the Booster Neutrino (BNB) beamline of the SBN experiment, ICARUS sits 795 m downstream and 5.75 degrees off-axis from the NuMI beam line. Due to the off-axis angle between NuMI and ICARUS, coupled with contributions from both pion and kaon decays to neutrino fluxes, interactions of NuMI neutrinos within ICARUS can be detected over a range of several GeV in energy. Measurements of these interactions present unique opportunities to infer neutrino interaction cross sections on an argon nuclear target within an energy range that overlaps both the SBN oscillation search and a significant portion of the DUNE spectrum. This poster will summarize the current status of muon-neutrino and muon-antineutrino charged current inclusive cross section measurements in ICARUS using the FHC and RHC NuMI sample respectively. Such inclusive measurements provide robust benchmarks for the overall interaction rate and muon kinematics, with reduced dependence on hadronic final-state modeling. The measurement of the muon-antineutrino Argon charged current inclusive cross section is particularly exciting and highly relevant for DUNE, given the scarcity of antineutrino-Argon cross section measurements in the literature. In addition, this poster will highlight ICARUS's first measurement of muon-neutrino Argon charged current mesonless final states using both transverse kinematic imbalance (TKI) variables and muon-proton kinematic variables. These measurements provide sensitivity to nuclear effects, final-state interactions, and nucleon correlations in argon, offering important constraints for improving neutrino interaction modeling for upcoming DUNE.

Roy, Promita [Fermilab; Virginia Tech.]↗
DOE OSTI2026

Status and plans for measurements of Neutrino-Argon interactions at ICARUS

The ICARUS experiment, utilizing Liquid Argon Time Projection Chamber (LAr TPC) technology, has been installed at Fermilab (USA), following its initial operation in Italy and subsequent refurbishment at CERN. ICARUS has successfully been taking physics data at Fermilab since June 2022. While the experiment’s primary objective is to function as the far detector of the Short Baseline Neutrino program (SBN), searching for hints of physics beyond three-flavour PMNS neutrino oscillations, ICARUS also offers other diverse physics capabilities, including searches beyond the standard model and measurements of cross-sections. In addition to being exposed to the common Booster Neutrino (BNB) beamline of the SBN experiment, ICARUS receives neutrinos from the Main Injector (NuMI) beam. Due to the off-axis angle between NuMI and ICARUS, coupled with contributions from both pion and kaon decays to neutrino fluxes, interactions of NuMI neutrinos within ICARUS can be detected over a range of several GeV in energy. Measurements of these interactions present unique opportunities to infer neutrino interaction cross sections on an argon nuclear target within an energy range that overlaps both the SBN oscillation search and a significant portion of the DUNE spectrum. This presentation will summarise the current status of ICARUS’ neutrino cross-section measurements.

Roy, Promita [Fermilab] (ORCID:0000000164958937)↗
DOE OSTI2021

Sub-GeV dark matter and neutrino searches with Skipper-CCDs: status and prospects

Thick fully-depleted charge-coupled devices (CCDs) with high-resistivity silicon are used in a wide range of scientific applications, from particle detection to astronomical imaging. Their low noise and high charge collection efficiency allow us to reach unprecedented sensitivity to physical processes with low-energy transfers. The newly-developed Skipper-CCD enhances this sensitivity by reducing the read-out noise reaching a sub-electron resolution. In this work, we summarize the fundamentals of the skipper-CCD operation and the prospects for both sub-GeV dark-matter searches and the detection of coherent elastic neutrino-nucleus scattering. A brief discussion of the challenges associated with the construction of the foreseen detectors with multi-kilogram target mass is also presented.

46 INSTRUMENTATION RELATED TO NUCLEAR SCIENCE AND ↗
DOE OSTI2022

The BDX experiment at Jefferson Laboratory

The Beam Dump Experiment (BDX) at Jefferson Laboratory (JLab) is an electron-beam thick-target experiment to search for Light Dark Matter (LDM) particles in the MeV-GeV mass range. BDX will exploit the high-intensity 10.6 GeV e^-e ? beam from CEBAF accelerator impinging on the beam dump of experimental Hall-A, collecting up to 10^{22}10 22 electrons-on-target (EOT) in a few years time. Any LDM particle produced by the interaction of the primary e^-e ? beam with the beam dump will be detected by measuring their scattering inside the BDX detector, an electromagnetic calorimeter surrounded by an hermetic veto system, which is to be installed in a dedicated underground facility, located 20 m downstream. Thanks to the large detection efficiency and background rejection capabilities, BDX will be able to explore a so-far unknown region in the LDM parameter space, improving current exclusion limits by one order of magnitude in case of a null observation. In preparation to the full experiment, a small-scale version called BDX-MINI, has been built and operated at JLab with a lower energy beam. Despite the small interaction volume, the large accumulated charge of 2.2\times10^{21}2.2×10 21 EOT allowed for the BDX-MINI measurement to set competitive exclusion limits on the LDM parameters space, comparable to those reported by larger-scale efforts.

Celentano, A.↗
DOE OSTI2020

Transits of Known Planets Orbiting a Naked-eye Star

Some of the most scientifically valuable transiting planets are those that were already known from radial velocity (RV) surveys. This is primarily because their orbits are well characterized and they preferentially orbit bright stars that are the targets of RV surveys. The Transiting Exoplanet Survey Satellite (TESS) provides an opportunity to survey most of the known exoplanet systems in a systematic fashion to detect possible transits of their planets. HD 136352 (Nu{sup 2} Lupi) is a naked-eye (V = 5.78) G-type main-sequence star that was discovered to host three planets with orbital periods of 11.6, 27.6, and 108.1 days via RV monitoring with the High Accuracy Radial velocity Planet Searcher (HARPS) spectrograph. We present the detection and characterization of transits for the two inner planets of the HD 136352 system, revealing radii of 1.482{sub −0.056}{sup +0.058} R {sub ⊕} and 2.608{sub −0.077}{sup +0.078} R {sub ⊕} for planets b and c, respectively. We combine new HARPS observations with RV data from the Keck/High Resolution Echelle Spectrometer and the Anglo-Australian Telescope, along with TESS photometry from Sector 12, to perform a complete analysis of the system parameters. The combined data analysis results in extracted bulk density values of ρ{sub b}=7.8{sub −1.1}{sup +1.2} g cm{sup −3} and ρ{sub c}=3.50{sub −0.36}{sup +0.41} g cm{sup −3} for planets b and c, respectively, thus placing them on either side of the radius valley. The combination of the multitransiting planet system, the bright host star, and the diversity of planetary interiors and atmospheres means this will likely become a cornerstone system for atmospheric and orbital characterization of small worlds.

79 ASTRONOMY AND ASTROPHYSICS↗
NASA NTRS1976

Optical data processing study

An onboard coherent optical data processing system was designed to handle large information content of imagery at high speeds, reduce redundancy in picture transmission, and detect specific image features. Theoretically derived Fourier transform characteristics for simple but representative two dimensional images served as a basis for predicting expected features of actual target images. Fourier transformation and spatial filtering of coherent optical images was accomplished theoretically and in the laboratory. The effect of various parameters such as optical aperature, incidence angles, the transparency assumption, the thin lens approximation on resolution, and performance of the system are predicted and tested.

Pinson, L. J.↗
NASA NTRS1984

SETI science working group report

This report covers the initial activities and deliberations of a continuing working group asked to assist the SETI Program Office at NASA. Seven chapters present the group's consensus on objectives, strategies, and plans for instrumental R&D and for a microwave search for extraterrestrial in intelligence (SETI) projected for the end of this decade. Thirteen appendixes reflect the views of their individual authors. Included are discussions of the 8-million-channel spectrum analyzer architecture and the proof-of-concept device under development; signal detection, recognition, and identification on-line in the presence of noise and radio interference; the 1-10 GHz sky survey and the 1-3 GHz targeted search envisaged; and the mutual interests of SETI and radio astronomy. The report ends with a selective, annotated SETI reading list of pro and contra SETI publications.

Drake, F.↗
NASA NTRS1990

Geoscience Laser Ranging System - Estimated accuracy of geodetic parameters and their dependence on system characteristics

Covariance analysis of the performance of the Geoscience Laser Ranging System (GLRS) indicates that three-dimensional relative positions can be recovered to an accuracy of several millimeters over spatial scales from a few kilometers to several hundred kilometers and over temporal scales as short as several days. The key factors influencing the accuracy are range noise, number of targets and their locations, system pointing capability, dwell time on the targets, orbital geometry, and gravity field uncertainties. Based on the present trade-off studies, GLRS is designed to provide range measurements with 10 mm or better accuracy, fire at a rate of 40 pulses-per-second, point over a cone extending to 50 deg from nadir, and operate with a dwell time on individual targets of 2 s or less. Given a strain rate of 10 to the -14th/s, estimated GLRS accuracy parameters suggest that the deformation can be detected in less than a month if it extends over 100 km and in less than 6 months if it extends over 10 km.

Cohen, Steven C.↗