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At least 1,513 records · Page 84
All sourcesNASA NTRSDOE OSTI
NASA NTRS1993

Optical spectroscopy of a highly fluorescent aggregate of bacteriochlorophyll c

Bacteriochlorophyll (BChl) c and a similar model compound, Mg-methyl bacteriopheophorbide d, form several types of aggregates in nonpolar solvents. One of these aggregates is highly fluorescent, with a quantum yield higher than that of the monomer. This aggregate is also unusual in that it shows a rise time in its fluorescence emission decay at certain wavelengths, which is ascribed to a change in conformation of the aggregate. An analysis of fluorescence depolarization data is consistent with either a linear aggregate of four or five monomers or preferably a cyclic arrangement of three dimers.

NASA Discipline Exobiology↗
NASA NTRS2004

GRB 021211 as a Faint Analogue of GRB 990123: Exploring the Similarities and Differences in the Optical Afterglows

We present BVR(sub c)JHK(sub s) photometry of the optical afterglow of the gamma-ray burst GRB 021211 taken at the Magellan, MMT, and WIYN observatories between 0.7 and 50 days after the burst. We find an intrinsic spectral slope at optical and near-infrared wavelengths of 0.69 +/- 0.14 at 0.87 days. The optical decay during the first day is almost identical to that of GRB 990123 except that GRB 021211's optical afterglow was intrinsically approximately 38 times fainter and the transition from the reverse shock to the forward shock may have occurred earlier than it did for GRB 990123. We find no evidence for a jet break or the cooling break passing through optical frequencies during the first day after the burst. There is weak evidence for a break in the J-band decay between 0.89 and 1.87 days which may be due to a jet. The optical and infrared data are consistent with a relativistic fireball where the shocked electrons are in the slow cooling regime and the electron index is 2.3 +/- 0.1. The burst appears to have occurred in a homogeneous ambient medium. Our analysis suggests that the jet of GRB 021211 may have a small opening angle (1.4 deg-4.4 deg) and that the total gamma-ray energy is much less than the canonical value of 1.33 x 10(exp 51) erg. If, this is the case then most of the energy of the burst may be in another form such as a frozen magnetic field, in supernova ejecta, or in a second jet component. The host galaxy of GRB 021211 is subluminous and has a star formation rate of at least 1 solar mass/yr.

Holland, Stephen T.↗
NASA NTRS2004

An Expanded RXTE Survey of Long-Term X-ray Variability in Seyfert 1 Galaxies

The first seven years of RXTE monitoring of Seyfert 1 active galactic nuclei have been systematically analyzed to yield five homogenous samples of 2-12 keV light curves, probing hard X-ray variability on successively longer durations from approx. 1 day to approx. 3.5 years. 2-10 keV variability on time scales of approx. 1 day, as probed by ASCA, are included. All sources exhibit stronger X-ray variability towards longer time scales, with variability amplitudes saturating at the longest time scales, but the increase is greater for relatively higher luminosity sources. The well-documented anticorrelation between variability amplitude and luminosity is confirmed on all time scales. However, anticorrelations between variability amplitude and black hole mass estimate are evident on only the shortest time scales probed. The data are consistent with the models of power spectral density (PSD) movement described in Markowitz et al. (2003) and McHardy et al. (2004), whereby Seyfert 1 galaxies variability can be described by a single, universal PSD shape whose cutoff frequency scales with black hole mass. The best-fitting scaling relations between variability time scale, black hole mass and X-ray luminosity support an average accretion rate of 2% of the Eddington limit for the sample. Nearly all sources exhibit stronger variability in the relatively soft 2-4 keV band compared to the 7-12 keV band on all time scales. Color-flux diagrams support also Seyfert 1s' softening as they brighten. There are indications that relatively less luminous or less massive sources exhibit a greater degree of spectral variability for a given increase in overall flux.

Markowitz, A.↗
NASA NTRS2001

Effects of hypergravity exposure on the developing central nervous system: possible involvement of thyroid hormone

The present study examined the effects of hypergravity exposure on the developing brain and specifically explored the possibility that these effects are mediated by altered thyroid status. Thirty-four timed-pregnant Sprague-Dawley rats were exposed to continuous centrifugation at 1.5 G (HG) from gestational Day 11 until one of three key developmental points: postnatal Day (P) 6, P15, or P21 (10 pups/dam: 5 males/5 females). During the 32-day centrifugation, stationary controls (SC, n = 25 dams) were housed in the same room as HG animals. Neonatal body, forebrain, and cerebellum mass and neonatal and maternal thyroid status were assessed at each time point. The body mass of centrifuged neonates was comparatively lower at each time point. The mass of the forebrain and the mass of the cerebellum were maximally reduced in hypergravity-exposed neonates at P6 by 15.9% and 25.6%, respectively. Analysis of neonatal plasma suggested a transient hypothyroid status, as indicated by increased thyroid stimulating hormone (TSH) level (38.6%) at P6, while maternal plasma TSH levels were maximally elevated at P15 (38.9%). Neither neonatal nor maternal plasma TH levels were altered, suggesting a moderate hypothyroid condition. Thus, continuous exposure of the developing rats to hypergravity during the embryonic and neonatal periods has a highly significant effect on the developing forebrain and cerebellum and neonatal thyroid status (P < 0.05, Bonferroni corrected). These data are consistent with the hypothesized role of the thyroid hormone in mediating the effect of hypergravity in the developing central nervous system and begin to define the role of TH in the overall response of the developing organism to altered gravity.

Non-NASA Center↗
NASA NTRS2001

The Ca(2+) status of the endoplasmic reticulum is altered by induction of calreticulin expression in transgenic plants

To investigate the endoplasmic reticulum (ER) Ca(2+) stores in plant cells, we generated tobacco (Nicotiana tabacum; NT1) suspension cells and Arabidopsis plants with altered levels of calreticulin (CRT), an ER-localized Ca(2+)-binding protein. NT1 cells and Arabidopsis plants were transformed with a maize (Zea mays) CRT gene in both sense and antisense orientations under the control of an Arabidopsis heat shock promoter. ER-enriched membrane fractions from NT1 cells were used to examine how altered expression of CRT affects Ca(2+) uptake and release. We found that a 2.5-fold increase in CRT led to a 2-fold increase in ATP-dependent (45)Ca(2+) accumulation in the ER-enriched fraction compared with heat-shocked wild-type controls. Furthermore, after treatment with the Ca(2+) ionophore ionomycin, ER microsomes from NT1 cells overproducing CRT showed a 2-fold increase in the amount of (45)Ca(2+) released, and a 2- to 3-fold increase in the amount of (45)Ca(2+) retained compared with wild type. These data indicate that altering the production of CRT affects the ER Ca(2+) pool. In addition, CRT transgenic Arabidopsis plants were used to determine if altered CRT levels had any physiological effects. We found that the level of CRT in heat shock-induced CRT transgenic plants correlated positively with the retention of chlorophyll when the plants were transferred from Ca(2+)-containing medium to Ca(2+)-depleted medium. Together these data are consistent with the hypothesis that increasing CRT in the ER increases the ER Ca(2+) stores and thereby enhances the survival of plants grown in low Ca(2+) medium.

NASA Discipline Plant Biology↗
NASA NTRS1988

Alpha, beta, or gamma: where does all the diversity go?

Global taxonomic richness is affected by variation in three components: within-community, or alpha, diversity, between-community, or beta, diversity; and between-region, or gamma, diversity. A data set consisting of 505 faunal lists distributed among 40 stratigraphic intervals and six environmental zones was used to investigate how variation of alpha and beta diversity influenced global diversity through the Paleozoic, and especially during the Ordovician radiations. As first shown by Bambach (1977), alpha diversity increased by 50 to 70 percent in offshore marine environments during the Ordovician and then remained essentially constant of the remainder of the Paleozoic. The increase is insufficient, however, to account for the 300 percent rise observed in global generic diversity. It is shown that beta diversity among level, soft-bottom communities also increased significantly during the early Paleozoic. This change is related to enhanced habitat selection, and presumably increased overall specialization, among diversifying taxa during the Ordovician radiations. Combined with alpha diversity, the measured change in beta diversity still accounts for only about half of the increase in global diversity. Other sources of increase are probably not related to variation in gamma diversity but rather to appearance and/or expansion of organic reefs, hardground communities, bryozoan thickets, and crinoid gardens during the Ordovician.

NASA Discipline Exobiology↗
NASA NTRS2000

Prostaglandin E2-induced up-regulation of c-fos messenger ribonucleic acid is primarily mediated by 3',5'-cyclic adenosine monophosphate in MC3T3-E1 osteoblasts

The mechanism by which the proto-oncogene, c-fos, is up-regulated in response to PGE2 in the mouse osteoblastic (MC3T3-E1) cell line was investigated using RT-PCR. c-fos messenger RNA up-regulation by dmPGE2 is rapid, starting 10 min post stimulation, and transient. The specific protein kinase A (PKA) inhibitor, H89, inhibited c-fos induction. Moreover, down-regulation of protein kinase C (PKC) activity by chronic TPA treatment had no effect on the induction of c-fos by dmPGE2. We conclude that up-regulation of c-fos by dmPGE2 is primarily dependent on PKA in MC3T3-E1 osteoblasts. In S49 lymphoma wild-type but not S49 cyc- cells, which are deficient in cAMP signaling, dmPGE2 up-regulates c-fos and increases cell growth compared with unstimulated cells. Thus in S49 lymphoma cells, c-fos induction by PGE2 is also dependent on cAMP signaling. The minimal c-fos promoter region required for dmPGE2-induced expression was identified by transfecting c-fos promoter deletion constructs coupled to the chloramphenicol acetyltransferase (CAT) reporter gene into Vero cells. Transfection of a plasmid containing 99 bp c-fos proximal promoter was sufficient to direct c-fos/CAT expression following stimulation with dmPGE2. Because induction of c-fos is mediated by cAMP, these data are consistent with activation of c-fos via the CRE/ATF cis element.

NASA Discipline Cell Biology↗
NASA NTRS1999

Migration of lymphocytes on fibronectin-coated surfaces: temporal evolution of migratory parameters

Lymphocytes typically interact with implanted biomaterials through adsorbed exogenous proteins. To provide a more complete characterization of these interactions, analysis of lymphocyte migration on adsorbed extracellular matrix proteins must accompany the commonly performed adhesion studies. We report here a comparison of the migratory and adhesion behavior of Jurkat cells (a T lymphoblastoid cell line) on tissue culture treated and untreated polystyrene surfaces coated with various concentrations of fibronectin. The average speed of cell locomotion showed a biphasic response to substrate adhesiveness for cells migrating on untreated polystyrene and a monotonic decrease for cells migrating on tissue culture-treated polystyrene. A modified approach to the persistent random walk model was implemented to determine the time dependence of cell migration parameters. The random motility coefficient showed significant increases with time when cells migrated on tissue culture-treated polystyrene surfaces, while it remained relatively constant for experiments with untreated polystyrene plates. Finally, a cell migration computer model was developed to verify our modified persistent random walk analysis. Simulation results suggest that our experimental data were consistent with temporally increasing random motility coefficients.

NASA Program Fundamental Space Biology↗
NASA NTRS2004

Non-Thermal Hard X-Ray Emission in Galaxy Clusters Observed with the BeppoSAX PDS

We study the X-ray emission in a sample of galaxy clusters using the BeppoSAX PDS instrument in the 20-80 keV energy band. We estimate the nonthermal hard X-ray (HXR) cluster emission by modeling the thermal contribution from the cluster gas and the nonthermal contamination from the unobscured active galactic nuclei (AGNs) in the clusters. We also evaluate the systematic uncertainties due to the background fluctuations. Assuming negligible contamination from the obscured AGNs, the resulting nonthermal component is detected at a 2 sigma level in approx. 50% of the nonsignificantly AGN-contaminated clusters: A2142, A2199, A2256, A3376, Coma, Ophiuchus, and Virgo. The data are consistent with a scenario whereby relaxed clusters have no hard X-ray component of nonthermal origin, whereas merger clusters do, with a 20-80 keV luminosity of approx. 10(exp 43)-10(exp 44) h(sup -2 sub 50) ergs/s. The co-added spectrum of the above clusters indicates a power-law spectrum for the HXR emission with a photon index of 2.8(sup +0.3 sub -0.4) in the 12-115 keV band, and we find indication that it has extended distribution. These indications argue against significant contamination from obscured AGNs, which have harder spectra and a centrally concentrated distribution. These results are supportive of the assumption of the merger shock acceleration of electrons in clusters, which has been proposed as a possible origin of the nonthermal hard X-ray emission models. Assuming that the cosmic microwave background photons experience inverse Compton scattering from the merger-accelerated relativistic electrons and thus produce the observed HXR, the measured hard X-ray slope corresponds to a differential momentum spectra of the relativistic electrons with a slope of mu = 3.8-5.0. In presence of cluster magnetic fields this relativistic electron population produces synchrotron emission with a spectral index of 1.4-2.1, consistent with radio halo observations of merger clusters. Thus both hard X-ray and radio observations of merger clusters are consistent with the inverse Compton model.

Nevalainen, J.↗
NASA NTRS2004

Asymmetrical Capacitors for Propulsion

Asymmetrical Capacitor Thrusters have been proposed as a source of propulsion. For over eighty years, it has been known that a thrust results when a high voltage is placed across an asymmetrical capacitor, when that voltage causes a leakage current to flow. However, there is surprisingly little experimental or theoretical data explaining this effect. This paper reports on the results of tests of several Asymmetrical Capacitor Thrusters (ACTs). The thrust they produce has been measured for various voltages, polarities, and ground configurations and their radiation in the VHF range has been recorded. These tests were performed at atmospheric pressure and at various reduced pressures. A simple model for the thrust was developed. The model assumed the thrust was due to electrostatic forces on the leakage current flowing across the capacitor. It was further assumed that this current involves charged ions which undergo multiple collisions with air. These collisions transfer momentum. All of the measured data was consistent with this model. Many configurations were tested, and the results suggest general design principles for ACTs to be used for a variety of purposes.

Canning, Francis X.↗
NASA NTRS1996

Laser ablation of Drosophila embryonic motoneurons causes ectopic innervation of target muscle fibers

We have tested the effects of neuromuscular denervation in Drosophila by laser-ablating the RP motoneurons in intact embryos before synaptogenesis. We examined the consequences of this ablation on local synaptic connectivity in both 1st and 3rd instar larvae. We find that the partial or complete loss of native innervation correlates with the appearance of alternate inputs from neighboring motor endings and axons. These collateral inputs are found at ectopic sites on the denervated target muscle fibers. The foreign motor endings are electrophysiologically functional and are observed on the denervated muscle fibers by the 1st instar larval stage. Our data are consistent with the existence of a local signal from the target environment, which is regulated by innervation and influences synaptic connectivity. Our results show that, despite the stereotypy of Drosophila neuromuscular connections, denervation can induce local changes in connectivity in wild-type Drosophila, suggesting that mechanisms of synaptic plasticity may also be involved in normal Drosophila neuromuscular development.

Non-NASA Center↗
NASA NTRS1996

A microstructural approach to cytoskeletal mechanics based on tensegrity

Mechanical properties of living cells are commonly described in terms of the laws of continuum mechanics. The purpose of this report is to consider the implications of an alternative approach that emphasizes the discrete nature of stress bearing elements in the cell and is based on the known structural properties of the cytoskeleton. We have noted previously that tensegrity architecture seems to capture essential qualitative features of cytoskeletal shape distortion in adherent cells (Ingber, 1993a; Wang et al., 1993). Here we extend those qualitative notions into a formal microstructural analysis. On the basis of that analysis we attempt to identify unifying principles that might underlie the shape stability of the cytoskeleton. For simplicity, we focus on a tensegrity structure containing six rigid struts interconnected by 24 linearly elastic cables. Cables carry initial tension ("prestress") counterbalanced by compression of struts. Two cases of interconnectedness between cables and struts are considered: one where they are connected by pin-joints, and the other where the cables run through frictionless loops at the junctions. At the molecular level, the pinned structure may represent the case in which different cytoskeletal filaments are cross-linked whereas the looped structure represents the case where they are free to slip past one another. The system is then subjected to uniaxial stretching. Using the principal of virtual work, stretching force vs. extension and structural stiffness vs. stretching force relationships are calculated for different prestresses. The stiffness is found to increase with increasing prestress and, at a given prestress, to increase approximately linearly with increasing stretching force. This behavior is consistent with observations in living endothelial cells exposed to shear stresses (Wang & Ingber, 1994). At a given prestress, the pinned structure is found to be stiffer than the looped one, a result consistent with data on mechanical behavior of isolated, cross-linked and uncross-linked actin networks (Wachsstock et al., 1993). On the basis of our analysis we concluded that architecture and the prestress of the cytoskeleton might be key features that underlie a cell's ability to regulate its shape.

NASA Discipline Cell Biology↗
NASA NTRS1996

Quantitative assessment of the cataractogenic potential of very low doses of neutrons

We report on the prevalence and relative biological effectiveness (RBE) for various stages of lens opacification in rats induced by very low doses (2 to 250 mGy) of medium-energy (440 keV) neutrons, compared to those for X rays. Neutron doses were delivered either in a single fraction or in four separate fractions and the irradiated animals were followed for over 100 weeks. At the highest observed dose (250 mGy) and at early observation times, there was evidence of an inverse dose-rate effect; i.e., a fractionated exposure was more potent than a single exposure. Neutron RBEs relative to X rays were estimated using a non-parametric technique. The results were only weakly dependent on time postirradiation. At 30 weeks, for example, 80% confidence intervals for the RBE of acutely delivered neutrons relative to X rays were 8-16 at 250 mGy, 10-20 at 50 mGy, 50-100 at 10 mGy and 250-500 at 2 mGy. The results are consistent with the estimated neutron RBEs in Japanese A-bomb survivors, though broad confidence bounds are present in the Japanese results. Our findings are also consistent with data reported earlier for cataractogenesis induced by heavy ions in rats, mice, and rabbits. We conclude from these results that, at very low doses (<10 mGy), the RBE for neutron-induced cataractogenesis is considerably larger than the RBE of 20 commonly used, and use of a significantly larger value for calculating equivalent dose would be prudent.

NASA Discipline Radiation Health↗
NASA NTRS1992

Evidence for a membrane defect in Alzheimer disease brain

To determine whether neurodegeneration in Alzheimer disease brain is associated with degradation of structural cell membrane molecules, we measured tissue levels of the major membrane phospholipids and their metabolites in three cortical areas from postmortem brains of Alzheimer disease patients and matched controls. Among phospholipids, there was a significant (P less than 0.05) decrease in phosphatidylcholine and phosphatidylethanolamine. There were significant (P less than 0.05) decreases in the initial phospholipid precursors choline and ethanolamine and increases in the phospholipid deacylation product glycerophosphocholine. The ratios of glycerophosphocholine to choline and glycerophosphoethanolamine to ethanolamine were significantly increased in all examined Alzheimer disease brain regions. The activity of the glycerophosphocholine-degrading enzyme glycerophosphocholine choline-phosphodiesterase was normal in Alzheimer disease brain. There was a near stoichiometric relationship between the decrease in phospholipids and the increase of phospholipid catabolites. These data are consistent with increased membrane phospholipid degradation in Alzheimer disease brain. Similar phospholipid abnormalities were not detected in brains of patients with Huntington disease, Parkinson disease, or Down syndrome. We conclude that the phospholipid abnormalities described here are not an epiphenomenon of neurodegeneration and that they may be specific for the pathomechanism of Alzheimer disease.

NASA Discipline Regulatory Physiology↗
NASA NTRS2003

Thermal Conductivity of Liquid He-4 near the Superfluid Transition in Restricted Geometries

We present measurements of the thermal conductivity near the superfluid transition of He-4 in confined geometries. The confinements we have studied include: cylindrical geometries with radii L=.5 and 1.0 microns, and parallel plates with 5 micron spacing. For L=1.0 microns, measurements at six pressures were conducted, whereas only SVP measurements have been done for other geometries. For the 1-D confinement in cylinders, the data are consistent with a universal scaling for all pressures at and above T(sub lambda). There are indications of breakdown of scaling and universality below T(sub lambda). For the 2-D confinement between parallel plates, the preliminary results indicate that the thermal conductivity is finite at the bulk superfluid transition temperature. Further analyses are needed to compare the 2-D results with those in bulk and 1-D confinement.

Liu, Yuanming↗