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At least 1,513 records · Page 84
All sourcesNASA NTRSDOE OSTI
NASA NTRS2002

Attenuated sympathetic nerve responses after 24 hours of bed rest

Bed rest reduces orthostatic tolerance. Despite decades of study, the cause of this phenomenon remains unclear. In this report we examined hemodynamic and sympathetic nerve responses to graded lower body negative pressure (LBNP) before and after 24 h of bed rest. LBNP allows for baroreceptor disengagement in a graded fashion. We measured heart rate (HR), cardiac output (HR x stroke volume obtained by echo Doppler), and muscle sympathetic nerve activity (MSNA) during a progressive and graded LBNP paradigm. Negative pressure was increased by 10 mmHg every 3 min until presyncope or completion of -60 mmHg. After bed rest, LBNP tolerance was reduced in 11 of 13 subjects (P <.023), HR was greater (P <.002), cardiac output was unchanged, and the ability to augment MSNA at high levels of LBNP was reduced (rate of rise for 30- to 60-mmHg LBNP before bed rest 0.073 bursts x min(-1) x mmHg(-1); after bed rest 0.035 bursts x min(-1) x mmHg(-1); P < 0.016). These findings suggest that 24 h of bed rest reduces sympathetic nerve responses to LBNP.

NASA Discipline Neuroscience↗
NASA NTRS1999

New approaches to the Doppler echocardiographic assessment of diastolic function: from research laboratory to clinical practice

Over the past decade, Doppler echocardiography has become a well-established tool for the diagnosis of left ventricular diastolic dysfunction. Unfortunately, in many clinical situations traditional Doppler indices of transmittal and pulmonary venous flow are inconclusive, primarily due to their dependence on left atrial pressure. Recently, new Doppler indices that are much less dependent on preload have been developed, based on intraventricular flow propagation and intrinsic myocardial velocity. These methodologies provide direct assessment of ventricular relaxation and the small intraventricular pressure gradients essential to efficient filling of the ventricle. We review in this article the theoretical and experiment background of these new echo techniques as well as how they can be implemented in routine clinical practice.

NASA Discipline Cardiopulmonary↗
NASA NTRS1987

Right and left ventricular volumes in vitro by a new nongeometric method

We present an evaluation of a new nongeometric technique for calculating right and left ventricular volumes. This method calculates ventricular chamber volumes from multiple cross-sectional echocardiographic views taken from a single point as the echo beam is tilted progressively through the ventricle. Right and left ventricular volumes are calculated from both the approximate short axis and approximate apical position on 20 in vitro human hearts and compared with the actual chamber volumes. The results for both ventricles from both positions are excellent. Correlation coefficients are > 0.95 for all positions; the standard errors are in the range of 5 to 7 mL and the slopes and intercepts for the regression lines are not significantly different from 1 and 0, respectively (except for the left ventricular short-axis intercept). For all positions, approximately 6 to 8 views are needed for peak accuracy (7.5 degrees to 10 degrees separation). This approach offers several advantages. No geometric assumptions about ventricular shape are made. All images are acquired from a single point (or window), and the digitized points can be used to make a three-dimensional reconstruction of the ventricle. Also, during the calculations a volume distribution curve for the ventricle is produced. The shape of this curve can be characteristic for certain situations (ie, right ventricle, short axis) and can be used to make new simple equations for calculating volume. We conclude that this is an accurate nongeometric method for determining both right and left ventricular volumes in vitro.

NASA Discipline Cardiopulmonary↗
NASA NTRS2001

Tortuosity measurement and the effects of finite pulse widths on xenon gas diffusion NMR studies of porous media

We have extended the utility of NMR as a technique to probe porous media structure over length scales of approximately 100-2000 microm by using the spin 1/2 noble gas 129Xe imbibed into the system's pore space. Such length scales are much greater than can be probed with NMR diffusion studies of water-saturated porous media. We utilized Pulsed Gradient Spin Echo NMR measurements of the time-dependent diffusion coefficient, D(t), of the xenon gas filling the pore space to study further the measurements of both the pore surface-area-to-volume ratio, S/V(p), and the tortuosity (pore connectivity) of the medium. In uniform-size glass bead packs, we observed D(t) decreasing with increasing t, reaching an observed asymptote of approximately 0.62-0.65D(0), that could be measured over diffusion distances extending over multiple bead diameters. Measurements of D(t)/D(0) at differing gas pressures showed this tortuosity limit was not affected by changing the characteristic diffusion length of the spins during the diffusion encoding gradient pulse. This was not the case at the short time limit, where D(t)/D(0) was noticeably affected by the gas pressure in the sample. Increasing the gas pressure, and hence reducing D(0) and the diffusion during the gradient pulse served to reduce the previously observed deviation of D(t)/D(0) from the S/V(p) relation. The Pade approximation is used to interpolate between the long and short time limits in D(t). While the short time D(t) points lay above the interpolation line in the case of small beads, due to diffusion during the gradient pulse on the order of the pore size, it was also noted that the experimental D(t) data fell below the Pade line in the case of large beads, most likely due to finite size effects.

Non-NASA Center↗
NASA NTRS2001

Real-time three-dimensional color Doppler echocardiography for characterizing the spatial velocity distribution and quantifying the peak flow rate in the left ventricular outflow tract

Quantification of flow with pulsed-wave Doppler assumes a "flat" velocity profile in the left ventricular outflow tract (LVOT), which observation refutes. Recent development of real-time, three-dimensional (3-D) color Doppler allows one to obtain an entire cross-sectional velocity distribution of the LVOT, which is not possible using conventional 2-D echo. In an animal experiment, the cross-sectional color Doppler images of the LVOT at peak systole were derived and digitally transferred to a computer to visualize and quantify spatial velocity distributions and peak flow rates. Markedly skewed profiles, with higher velocities toward the septum, were consistently observed. Reference peak flow rates by electromagnetic flow meter correlated well with 3-D peak flow rates (r = 0.94), but with an anticipated underestimation. Real-time 3-D color Doppler echocardiography was capable of determining cross-sectional velocity distributions and peak flow rates, demonstrating the utility of this new method for better understanding and quantifying blood flow phenomena.

NASA Discipline Cardiopulmonary↗
NASA NTRS2004

The North Alabama Lightning Mapping Array: Recent Severe Storm Observations and Future Prospects

The North Alabama Lightning Mapping Array became operational in November 2001 as a principal component of a severe weather test bed to infuse new science and technology into the short-term forecasting of severe and hazardous weather, principally within nearby National Weather Service forecast offices. Since the installation of the LMA, it has measured the total lightning activity of a large number of severe weather events, including three supercell tornado outbreaks, two supercell hailstorm events, and numerous microburst-producing storms and ordinary non-severe thunderstorms. The key components of evolving storm morphology examined are the time rate-of-change (temporal trending) of storm convective and precipitation characteristics that can be diagnosed in real-time using NEXRAD WSR-88D Doppler radar (echo growth and decay, precipitation structures and velocity features, outflow boundaries), LMA (total lightning flash rate and its trend) and National Lightning Detection Network (cloud-to- ground lightning, its polarity and trends). For example, in a transitional season supercell tornado outbreak, peak total flash rates for typical supercells in Tennessee reached 70-100/min, and increases in the total flash rate occurred during storm intensification as much as 20-25 min prior to at least some of the tornadoes. The most intense total flash rate measured during this outbreak (over 800 flashes/min) occurred in a storm in Alabama. In the case of a severe summertime pulse thunderstorm in North Alabama, the peak total flash rate reached 300/min, with a strong increase in total lightning evident some 9 min before damaging winds were observed at the surface. In this paper we provide a sampling of LMA observations and products during severe weather events to illustrate the capability of the system, and discuss the prospects for improving the short-term forecasting of convective weather using total lightning data.

Goodman, S. J.↗
NASA NTRS1999

Single-shot diffusion measurement in laser-polarized Gas

A single-shot pulsed gradient stimulated echo sequence is introduced to address the challenges of diffusion measurements of laser polarized 3He and 129Xe gas. Laser polarization enhances the NMR sensitivity of these noble gases by >10(3), but creates an unstable, nonthermal polarization that is not readily renewable. A new method is presented which permits parallel acquisition of the several measurements required to determine a diffusive attenuation curve. The NMR characterization of a sample's diffusion behavior can be accomplished in a single measurement, using only a single polarization step. As a demonstration, the diffusion coefficient of a sample of laser-polarized 129Xe gas is measured via this method. Copyright 1999 Academic Press.

Non-NASA Center↗
NASA NTRS1999

New echocardiographic windows for quantitative determination of aortic regurgitation volume using color Doppler flow convergence and vena contracta

Color Doppler images of aortic regurgitation (AR) flow acceleration, flow convergence (FC), and the vena contracta (VC) have been reported to be useful for evaluating severity of AR. However, clinical application of these methods has been limited because of the difficulty in clearly imaging the FC and VC. This study aimed to explore new windows for imaging the FC and VC to evaluate AR volumes in patients and to validate this in animals with chronic AR. Forty patients with AR and 17 hemodynamic states in 4 sheep with strictly quantified AR volumes were evaluated. A Toshiba SSH 380A with a 3.75-MHz transducer was used to image the FC and VC. After routine echo Doppler imaging, patients were repositioned in the right lateral decubitus position, and the FC and VC were imaged from high right parasternal windows. In only 15 of the 40 patients was it possible to image clearly and measure accurately the FC and VC from conventional (left decubitus) apical or parasternal views. In contrast, 31 of 40 patients had clearly imaged FC regions and VCs using the new windows. In patients, AR volumes derived from the FC and VC methods combined with continuous velocity agreed well with each other (r = 0.97, mean difference = -7.9 ml +/- 9.9 ml/beat). In chronic animal model studies, AR volumes derived from both the VC and the FC agreed well with the electromagnetically derived AR volumes (r = 0.92, mean difference = -1.3 +/- 4.0 ml/beat). By imaging from high right parasternal windows in the right decubitus position, complementary use of the FC and VC methods can provide clinically valuable information about AR volumes.

NASA Discipline Cardiopulmonary↗
NASA NTRS2004

CO2 Condensation Models for Mars

During the polar night in both hemispheres of Mars, regions of low thermal emission, frequently referred to as "cold spots", have been observed by Mariner 9, Viking and Mars Global Surveyor (MGS) spacecraft. These cold spots vary in time and appear to be associated with topographic features suggesting that they are the result of a spectral-emission effect due to surface accumulation of fine-grained frost or snow. Presented here are simulations of the Martian polar night using the NASA Ames General Circulation Cloud Model. This cloud model incorporates all the microphysical processes of carbon dioxide cloud formation, including nucleation, condensation and sedimentation and is coupled to a surface frost scheme that includes both direct surface condensation and precipitation. Using this cloud model we simulate the Mars polar nights and compare model results to observations from the Thermal Emission Spectrometer (TES) and the Mars Orbiter Laser Altimeter (MOLA). Model predictions of "cold spots" compare well with TES observations of low emissivity regions, both spatially and as a function of season. The model predicted frequency of CO2 cloud formation also agrees well with MOLA observations of polar night cloud echoes. Together the simulations and observations in the North indicate a distinct shift in atmospheric state centered about Ls 270 which we believe may be associated with the strength of the polar vortex.

Colaprete, A.↗
NASA NTRS2004

The Severe Weather Outbreak of 10 November 2002: Lightning and Radar Analysis of Storms in the Deep South

On the afternoon and evening of 10 November 2002, the Midwest and Deep South were struck by a major outbreak of severe storms that produced some 80 tornadoes. In terms of number of tornadoes, this was the largest outbreak in the United States since November 1992. Some 32 of the tornadoes occurred in Tennessee, Mississippi, Alabama and Georgia, including several long-track killers. We use the North Alabama Lightning Mapping Array (LMA) and other data sources to perform a comprehensive analysis of the structure and evolution of the outbreak. Most of the Southern tornadoes occurred in isolated, fast-moving supercell storms that formed in warm, moist air ahead of a major cold front. Storms tended to form in lines parallel to storm cell motion, resulting in many communities being hit multiple times by severe storms that evening. Supercells in Tennessee produced numerous strong tornadoes with short to medium-length track paths, while the supercells further south produced several very long-track tornadoes. Radar data indicate that the Tennessee storms tended to split frequently, apparently limiting their ability to sustain long-lived tornadoes, while storms further south split at most one time. The differences between these storms appear to be related to the presence of stronger jetstream winds in Tennessee relative to those present in Mississippi, Alabama and Georgia. LMA-derived flash rates associated with most of the supercell storm cores were about 1-2 flashes per second. Rapid increases in lightning rates (or "jumps") occurred prior to tornado touchdown in many instances. Lightning "holes" (lightning-free regions associated with the echo-free vault) occurred in two of the Tennessee supercells. The complexity of the relationship between lightning and storm severity is revealed by the behavior of one Alabama supercell, which produced a peak flash rate of nearly 14 flashes per second, well after the end of its long-track tornado, while interacting and ultimately merging with a daughter supercell on its southwest flank. Close examination of this powerful storm indicates that its prodigious flash rate was the result of strong flash activity over an unusually large area, rather than a concentrated core of extremely high flash rate activity.

Buechler, D. E.↗
NASA NTRS2004

Radio Sounding Science at High Powers

Future space missions like the Jupiter Icy Moons Orbiter (JIMO) planned to orbit Callisto, Ganymede, and Europa can fully utilize a variable power radio sounder instrument. Radio sounding at 1 kHz to 10 MHz at medium power levels (10 W to kW) will provide long-range magnetospheric sounding (several Jovian radii) like those first pioneered by the radio plasma imager instrument on IMAGE at low power (less than l0 W) and much shorter distances (less than 5 R(sub E)). A radio sounder orbiting a Jovian icy moon would be able to globally measure time-variable electron densities in the moon ionosphere and the local magnetospheric environment. Near-spacecraft resonance and guided echoes respectively allow measurements of local field magnitude and local field line geometry, perturbed both by direct magnetospheric interactions and by induced components from subsurface oceans. JIMO would allow radio sounding transmissions at much higher powers (approx. 10 kW) making subsurface sounding of the Jovian icy moons possible at frequencies above the ionosphere peak plasma frequency. Subsurface variations in dielectric properties, can be probed for detection of dense and solid-liquid phase boundaries associated with oceans and related structures in overlying ice crusts.

Green, J. L.↗
NASA NTRS2004

Advances in Inner Magnetosphere Passive and Active Wave Research

This review identifies a number of the principal research advancements that have occurred over the last five years in the study of electromagnetic (EM) waves in the Earth's inner magnetosphere. The observations used in this study are from the plasma wave instruments and radio sounders on Cluster, IMAGE, Geotail, Wind, Polar, Interball, and others. The data from passive plasma wave instruments have led to a number of advances such as: determining the origin and importance of whistler mode waves in the plasmasphere, discovery of the source of kilometric continuum radiation, mapping AKR source regions with "pinpoint" accuracy, and correlating the AKR source location with dipole tilt angle. Active magnetospheric wave experiments have shown that long range ducted and direct echoes can be used to obtain the density distribution of electrons in the polar cap and along plasmaspheric field lines, providing key information on plasmaspheric filling rates and polar cap outflows.

Green, James L.↗
NASA NTRS1997

High resolution magnetic resonance imaging of the calcaneus: age-related changes in trabecular structure and comparison with dual X-ray absorptiometry measurements

A high-resolution magnetic resonance imaging (MRI) protocol, together with specialized image processing techniques, was applied to the quantitative measurement of age-related changes in calcaneal trabecular structure. The reproducibility of the technique was assessed and the annual rates of change for several trabecular structure parameters were measured. The MR-derived trabecular parameters were compared with calcaneal bone mineral density (BMD), measured by dual X-ray absorptiometry (DXA) in the same subjects. Sagittal MR images were acquired at 1.5 T in 23 healthy women (mean age: 49.3 +/- 16.6 [SD]), using a three-dimensional gradient echo sequence. Image analysis procedures included internal gray-scale calibration, bone and marrow segmentation, and run-length methods. Three trabecular structure parameters, apparent bone volume (ABV/TV), intercept thickness (I.Th), and intercept separation (I.Sp) were calculated from the MR images. The short- and long-term precision errors (mean %CV) of these measured parameters were in the ranges 1-2% and 3-6%, respectively. Linear regression of the trabecular structure parameters vs. age showed significant correlation: ABV/TV (r2 = 33.7%, P < 0.0037), I.Th (r2 = 26.6%, P < 0.0118), I.Sp (r2 = 28.9%, P < 0.0081). These trends with age were also expressed as annual rates of change: ABV/TV (-0.52%/year), I.Th (-0.33%/year), and I.Sp (0.59%/year). Linear regression analysis also showed significant correlation between the MR-derived trabecular structure parameters and calcaneal BMD values. Although a larger group of subjects is needed to better define the age-related changes in trabecular structure parameters and their relation to BMD, these preliminary results demonstrate that high-resolution MRI may potentially be useful for the quantitative assessment of trabecular structure.

NASA Discipline Number 26-10↗
NASA NTRS1996

Magnetic resonance imaging of the calcaneus: preliminary assessment of trabecular bone-dependent regional variations in marrow relaxation time compared with dual X-ray absorptiometry

RATIONALE AND OBJECTIVES: Marrow transverse relaxation time (T2*) in magnetic resonance (MR) imaging may be related to the density and structure of the surrounding trabecular network. We investigated regional variations of T2* in the human calcaneus and compared the findings with bone mineral density (BMD), as measured by dual X-ray absorpiometry (DXA). Short- and long-term precisions were evaluated first to determine whether MR imaging would be useful for the clinical assessment of disease status and progression in osteoporosis. METHODS: Gradient-recalled echo MR images of the calcaneus were acquired at 1.5 T from six volunteers. Measurements of T2* were compared with BMD and (for one volunteer) conventional radiography. RESULTS: T2* values showed significant regional variation; they typically were shortest in the superior region of the calcaneus. There was a linear correlation between MR and DXA measurements (r = .66 for 1/T2* versus BMD). Differences in T2* attributable to variations in analysis region-of-interest placement were not significant for five of the six volunteers. Sagittal MR images had short- and long-term precision errors of 4.2% and 3.3%, respectively. For DXA, the precision was 1.3% (coefficient of variation). CONCLUSION: MR imaging may be useful for trabecular bone assessment in the calcaneus. However, given the large regional variations in bone density and structure, the choice of an ROI is likely to play a major role in the accuracy, precision, and overall clinical efficacy of T2* measurements.

Non-NASA Center↗
NASA NTRS1995

[Quantification and monitoring of vascular resistance in the lower limbs by the Doppler method (animal model)]

The object of this study was to define and validate a non-invasive method of evaluation and monitoring of vascular resistances in the leg. Blood flow velocity was measured by Doppler ultrasound in an animal model (ewe) with similar blood flow characteristics in the lower limb as man and allowing access to the required invasive measurements for validation of the method (pressure and flow). Vascular resistances distal to the measuring point (femoral, for example) were assessed using the resistance index R = D/S, S being the peak systolic deflection and D that of diastolic reflux of the Doppler spectral analysis of flow in the femoral artery. The values and variations of this resistance index were compared with the vascular resistances calculated from measurements of pressure and flow at the point of Doppler sampling and expressed in mmHg/ml/min. Femoral flow was measured by Doppler ultrasound (Doppler-echo), and mean pressure by an arterial catheter introduced into the abdominal aorta. Compression of the lower limb veins induced a venous return resulting in a reduction of cardiac output and femoral flow. During compression, femoral flow decreased by an average of 29% (p < 0.001) although mean pressure and heart rate did not change significantly. The femoral resistance index (Rf) increased by an average of 37.5% (p < 0.01) and vascular resistances increased by 45.9% (p < 0.01). Injection of 1 mg adrenaline induced peripheral vasoconstriction with an increase in blood pressure and a decrease in heart rate and femoral flow.(ABSTRACT TRUNCATED AT 250 WORDS).

Non-NASA Center↗
NASA NTRS1947

Measurements of Atmospheric Turbulence on Seattle-Alaska Airways

For about the past year, American Airlines has been engaged in obtaining data on various uses of airborne radar under routine operating conditions. This work is under contract to the Navy Department, Bureau of Ships, and includes the investigation of radar as a navigational aid and terrain collision warning device and its use in icing and turbulence detection. In view of the work of the National Advisory Committee for Aeronautics on atmospheric turbulence, the NACA was requested to participate in the tests to the extent of obtaining and evaluating the turbulence data for use in the turbulence-detection phase of the work. Gust measurements and airborne radar observations were consequently obtained in February and March 1947 during routine flights of an American Airlines airplane on the Seattle-Alaska airways. Unfortunately, the weather conditions encountered during the flights gave no well-defined radar echoes and no comparison between radar indications end turbulence could be made. The gust data for the route, however, are of interest from an operational standpoint, and are presented herein for the information of the Navy Department in accordance with previous arrangements.

Funk, Jack↗
NASA NTRS2005

Lightning Contribution to Improvement of Passive Microwave Vertical Structure and Rainfall Estimation

Joint observations from the TRMM mission are used to examine the contribution which lightning observations can make towards estimation of vertical structure and rainfall from passive microwave data. Passive microwave (TMI) observations are binned into distinct vertical structure categories based on cluster analysis of radar (PR) vertical profiles and convective/stratiform (C/S) classifiers. TMI rain estimates are high-biased relative to radar for stratiform and mixed convective/stratiform vertical structures and low-biased relative to radar for convective structures. Significant ambiguity exists in the TMI brightness temperature space between midlevel stratiform and convective profile types which are primary contributors to tropical rainfall. The ambiguity is worst for convective profile types with radar echo tops within and just above the mixed-phase region. The ability of TMI data (including all low and high frequency polarized brightness temperatures; 19V, 19H, 21V, 37V, 37H, 85V, 85H) to predict vertical structure is assessed. The incremental benefit of including TMI convective/stratiform (C/S) classifiers (both 85 GHz polarization and 19, 37 and 85 GHz texture-based) and LZS lightning observations is then considered. The use of all parameters (brightness temperatures, TMI C/S classifiers, lightning data, predicted vertical structure) to reduce TMI/PR rainfall estimate scatter is demonstrated. For both vertical structure and rainfall estimation, inclusion of C/S classifiers and lightning observations provide statistical skill improvements but do not completely alleviate critical midlevel profile C/S ambiguity and related rain estimate errors.

Boccippio, Dennis↗
NASA NTRS2004

An Orbital "Virtual Radar" from TRMM Passive Microwave and Lightning Observations

The retrieval of vertical structure from joint passive microwave and lightning observations is demonstrated. Three years of data from the TRMM (Tropical Rainfall Measuring Mission) are used as a training dataset for regression and classification neural networks; the TMI (TRMM Microwave Imager) and LIS (Lightning Imaging Sensor) provide the inputs, the PR (Precipitation Radar) provides the training targets. Both vertical reflectivity profile categorization (into 9 convective, 7 stratiform, 2 mixed and 6 anvil types) and geophysical parameters (surface rainfall, vertically integrated liquid (VIL), ice water content (IWC) and echo tops) are retrieved. Retrievals are successful over both land and ocean surfaces. The benefit of using lightning observations as inputs to these retrievals is quantitatively demonstrated; lightning essentially provides an additional convective/stratiform discriminator, and is most important for isolation of midlevel (tops in the mixed phase region) convective profile types (this is because high frequency passive microwave observations already provide good convective/stratiform discrimination for deep convective profiles). This is highly relevant as midlevel convective profiles account for an extremely large fraction of tropical rainfall, and yet are most difficult to discriminate from comparable-depth stratiform profile types using passive microwave observations alone.

Boccippio, Dennis J.↗