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At least 1,477 records · Page 82

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DOE OSTI2020

A Foundational Study for Normal F8 -Containing Mouse Models for the miRNA Regulation of Hemophilia A: Identification and Analysis of Mouse miRNAs that Downregulate the Murine F8 Gene

Hemophilia A (HA) is associated with defects in the F8 gene, encoding coagulation factor VIII (FVIII). Our previous studies show that F8-targeting micro RNAs (miRNAs), a group of small RNAs involved in gene regulation, can downregulate F8 expression causing HA in individuals with normal F8-genotypes and increased HA severity in patients with mutations in F8. Understanding the mechanistic underpinnings of human genetic diseases caused or modulated by miRNAs require a small animal model, such as a mouse model. Here, we report a foundational study to develop such a model system. We identified the mouse 3'untranslated region (3'UTR) on murine F8-mRNA (muF8-mRNA) that can bind to murine miRNAs. We then selected three miRNAs for evaluation: miR-208a, miR-351 and miR-125a. We first demonstrate that these three miRNAs directly target the 3'UTR of muF8-mRNA and reduce the expression of a reporter gene (luciferase) mRNA fused to the muF8-3' UTR in mammalian cells. Furthermore, in mouse cells that endogenously express the F8 gene and produce FVIII protein, the ectopic expression of these miRNAs downregulated F8-mRNA and FVIII protein. These results provide proof-of-concept and reagents as a foundation for using a normal F8-containing mouse as a model for the miRNA regulation of normal F8 in causing or aggravating the genetic disease HA.

59 BASIC BIOLOGICAL SCIENCES↗

NASA NTRS1976

Retrospective studies of operating problems in air transport

An epidemiological model for the study of human errors in aviation is presented. In this approach, retrospective data are used as the basis for formulation of hypotheses as to system factors which may have contributed to such errors. Prospective experimental studies of aviation operations are also required in order to prove or disprove the hypotheses, and to evaluate the effectiveness of intervention techniques designed to solve operational problems in the aviation system.

Billings, C. E.↗

NASA NTRS1975

Analysis of pilot-aircraft performance and reliability via the application of man-machine models

The present approach to analytic modeling, which utilizes human response theory together with modern control theory, is discussed. Analytic modeling of human performance has progressed to the point where it can be used with some confidence in the design and performance analysis of man-machine systems. An example of its use in helping design a flight director for the hover control of a VTOL vehicle is described. How the method could be used for analysis of human response to system failure is sketched.

Kleinman, D. L.↗

NASA NTRS1989

Earth system science: A program for global change

The Earth System Sciences Committee (ESSC) was appointed to consider directions for the NASA Earth-sciences program, with the following charge: review the science of the Earth as a system of interacting components; recommend an implementation strategy for Earth studies; and define the role of NASA in such a program. The challenge to the Earth system science is to develop the capability to predict those changes that will occur in the next decade to century, both naturally and in response to human activity. Sustained, long-term measurements of global variables; fundamental descriptions of the Earth and its history; research foci and process studies; development of Earth system models; an information system for Earth system science; coordination of Federal agencies; and international cooperation are examined.

Source record↗

NASA NTRS1992

Viewing analyses for the assembly of Space Station Freedom (SSF)

Analyses are currently being conducted in the Man-Systems Division of the NASA Johnson Space Center, on the restructured Space Station Freedom configuration to determine viewing requirements for both robotic tasks and for extravehicular crew activities. The use of the PLAID software, a 3D modeling simulation tool, provides a simulation of the environment and the system hardware to identify potential problem areas needing further refinement in design development. This process enables human factor considerations and issues to be explored during the design process to identify and correct problems before hardware is actually constructed. Preliminary results have identified several potential viewing problem areas with the available lighting for both robotic and EVA tasks. To rectify the potential viewing problems identified through simulation, additional cameras and lighting enhancements are being proposed at various sites along the truss and on the Shuttle to provide more complete coverage of work task sites. Supplementing the existing cameras with color coded alignment aids will also help reduce the workload involved with robotic tasks.

Stealey, Sheryl↗

NASA NTRS1993

The Marshall Automated Weld System (MAWS)

A fully automated welding system, which can operate totally independent of human intervention, is currently unavailable in the welding industry. Development of the Marshall Automated Weld System (MAWS) has been undertaken to fill this void. The system will enable application of statistical process control practices to assure weld quality prior to post weld nondestructive testing. The Variable Polarity Plasma Arc (VPPA) welding process has been baselined for MAWS because it has eliminated process related defects in the welding of the Space Shuttle External Tank. The few remaining weld defects occurring on the tank can be associated with human error. The system integrates multiple sensors (providing real time information on weld bead geometry, weld joint location, wirefeed entry, and inert gas quality) with a weld model (describing weld geometry in relation to critical parameters) and computer-controlled VPPA weld equipment. This system is designed to provide real-time, closed-loop control of the weld as it is being made.

Russell, Carolyn K.↗

NASA NTRS1993

Use of ultrasound in altitude decompression modeling

A model that predicts the probability of developing decompression sickness (DCS) with various denitrogenation schedules is being developed by the Armstrong Laboratory, using human data from previous exposures. It was noted that refinements are needed to improve the accuracy and scope of the model. A commercially developed ultrasonic echo imaging system is being used in this model development. Using this technique, bubbles images from a subject at altitude can be seen in the gall bladder, hepatic veins, vena cava, and chambers of the heart. As judged by their motion and appearance in the vena cava, venous bubbles near the heart range in size from 30 to 300 M. The larger bubbles skim along the top, whereas the smaller ones appear as faint images near the bottom of the vessel. Images from growing bubbles in a model altitude chamber indicate that they grow rapidly, going from 20 to 100 M in 3 sec near 30,000 ft altitude. Information such as this is valuable in verifying those aspects of the DCS model dealing with bubble size, their growth rate, and their site of origin.

Olson, Robert M.↗

NASA NTRS1993

The Marshall Automated Weld System (MAWS)

A fully automated welding system, which can operate totally independent of human intervention, is currently unavailable in the welding industry. Development of the Marshall Automated Weld System (MAWS) has been undertaken to fill this void. The system will enable application of statistical process control practices to assure weld quality prior to post weld nondestructive testing. The Variable Polarity Plasma Arc (VPPA) welding process has been baselined for MAWS because it has eliminated process related defects in the welding of the Space Shuttle External Tank. The few remaining weld defects occurring on the tank can be associated with human error. The system integrates multiple sensors (providing real time information on weld bead geometry, weld joint location, wirefeed entry, and inert gas quality) with a weld model (describing weld geometry in relation to critical parameters) and computer controlled VPPA weld equipment. This system is designed to provide real-time, closed-loop control of the weld as it is being made.

Russell, Carolyn K.↗

NASA NTRS2004

Model-Drive Architecture for Agent-Based Systems

The Model Driven Architecture (MDA) approach uses a platform-independent model to define system functionality, or requirements, using some specification language. The requirements are then translated to a platform-specific model for implementation. An agent architecture based on the human cognitive model of planning, the Cognitive Agent Architecture (Cougaar) is selected for the implementation platform. The resulting Cougaar MDA prescribes certain kinds of models to be used, how those models may be prepared and the relationships of the different kinds of models. Using the existing Cougaar architecture, the level of application composition is elevated from individual components to domain level model specifications in order to generate software artifacts. The software artifacts generation is based on a metamodel. Each component maps to a UML structured component which is then converted into multiple artifacts: Cougaar/Java code, documentation, and test cases.

Gradanin, Denis↗

NASA NTRS2014

Vision Algorithms Catch Defects in Screen Displays

Andrew Watson, a senior scientist at Ames Research Center, developed a tool called the Spatial Standard Observer (SSO), which models human vision for use in robotic applications. Redmond, Washington-based Radiant Zemax LLC licensed the technology from NASA and combined it with its imaging colorimeter system, creating a powerful tool that high-volume manufacturers of flat-panel displays use to catch defects in screens.

Source record↗

NASA NTRSDate not supplied

Additively Manufactured Wind Tunnel Balances for Propulsive Force Measurement

Propulsive forces and moments during powered descent are not understood well enough to design an entry, decent, and landing vehicle with high confidence using solely computational fluid dynamics modelling (CFD). Therefore, wind tunnel testing is required to quantify uncertainties in computational modeling and simulation. Wind tunnel balances are structural, high-precision, multi-axis force transducers that provide direct measurement of these aerodynamic forces and moments, however their complex designs make them costly and time consuming to produce and approaches used to manufacture them have not changed significantly since the 1960s. This work demonstrates that additive manufacturing (AM) can be used to manufacture wind tunnel balances with significantly reduced fabrication time and expense. Moreover, the design flexibility afforded by the additive manufacturing process has the potential to enable new capabilities with respect to measuring propulsion forces during entry, decent, and landing testing. Here we present two novel balance designs enabled by AM. One will provide direct measurement of aerodynamic interference forces and moments on powered descent models (retropropulsion forces) to support CFD validation and further development of Mars human landing vehicle concepts. The second design will be used to characterize a reaction control system during entry descent and landing testing over a wide Mach number range.

Wind tunnel balance↗

NASA NTRSDate not supplied

Additively Manufactured Balances for Propulsive Force Measurement

Propulsive forces and moments during powered descent are not understood well enough to design an entry, decent, and landing vehicle with high confidence using solely computational fluid dynamics modelling (CFD). Therefore, wind tunnel testing is required to quantify uncertainties in computational modeling and simulation. Wind tunnel balances are structural, high-precision, multi-axis force transducers that provide direct measurement of these aerodynamic forces and moments, however their complex designs make them costly and time consuming to produce and approaches used to manufacture them have not changed significantly since the 1960s. This work demonstrates that additive manufacturing (AM) can be used to manufacture wind tunnel balances with significantly reduced fabrication time and expense. Moreover, the design flexibility afforded by the additive manufacturing process has the potential to enable new capabilities with respect to measuring propulsion forces during entry, decent, and landing testing. Here we present two novel balance designs enabled by AM. One will provide direct measurement of aerodynamic interference forces and moments on powered descent models (retropropulsion forces) to support CFD validation and further development of Mars human landing vehicle concepts. The second design will be used to characterize a reaction control system during entry decent and landing testing over a wide Mach number range.

Wind tunnel balance↗

NASA NTRSDate not supplied

Long Duration Medical System Foundation for Lunar Orbital and Lunar Surface Exploration Missions

For long-duration lunar orbital and lunar surface (LDLOS) exploration missions, the NASA Human Research Program (HRP) Exploration Medical Capability (ExMC) Element has developed a medical system foundation through which clinical considerations may be represented via a systems engineering-based model. Components of the Long Duration Medical System Foundation model include a concept of operations (ConOps), functional decomposition, medical conditions to be addressed, clinical capabilities and resources, technical requirements, and traces of requirements to NASA standards documents and parent-level (Program- and Vehicle habitat system-level) requirements. The Foundation model offers the means to present information in a readily accessible format that is understandable across all clinical, engineering, scientific, and managerial disciplines. Collectively, these components constitute a foundation that serves future programs with similar long duration mission profiles as a starting point for medical system design. The Foundation was developed by a multidisciplinary team of systems engineers, scientists, and clinicians across NASA. The process started with ConOps development, subsequently decomposed into the functionalities needed to diagnose, treat, and prevent medical conditions. The clinical team identified medical conditions most likely needed to be diagnosed and treated during a long-duration lunar exploration mission. Through these approaches, requirements were codified for the LDLOS medical system. These requirements were then traced to NASA standards, medical conditions, medical capabilities, and medical resources, facilitating stakeholders’ use of the Foundation model to analyze traces and to identify medical system interfaces with other vehicle systems or subsystems. In addition, the Foundation may be used as a basis for performing risk trades on medical system mass and volume allocation. This discussion will focus on the processes through which the LDLOS Medical System Foundation was developed, how the Foundation builds a bridge between the medical and engineering domains, and how these processes may be applied more broadly to a crew health and performance system and other system domains.

Jay Lemery↗

NASA NTRSDate not supplied

Development of Urban Air Mobility (UAM) Vehicles for Ease of Operation

To date the air transportation system has been developed with the in-cremental introduction of new technology and with highly experienced air transport pilots and air traffic controllers overseeing flight operations. Thus, we currently have one of the safest commercial aviation systems in the world. General Aviation (GA) in the United States, however, has not always followed the same cautious and monitored approach to implementation; consequently, the GA safety record does not meet the high standards of commercial aviation. Recently, a new system known as Urban Air Mobility (UAM), is attracting considerable interest and investment from industry and government agencies. UAM refers to a system of passenger and small-cargo air transportation vehicles within an urban area with the goal of reducing the number of times we need to use our cars, thus improving urban traffic by moving people and cargo from crowded single pas-senger vehicles on our roads to personal and on-demand air vehicles. These UAM vehicles will be small and based on electric, Vertical-Take-Off-and-Landing (eV-TOL) systems. A significant component of UAM is offloading of flight-man-agement responsibilities from human pilots to newly-developed autonomy. Cur-rently, over 100 UAM vehicles are either in development or production. Most, if not all, have a goal of fully autonomous vehicle operations, but fully autonomous flying vehicles are not expected in the near future. Therefore, we are de-veloping concepts for UAM vehicles that will be easy to fly and/or manage by operators with minimal pilot training. In this paper we will discuss our human-automation teaming approach to develop an easy-to-operate VTOL aircraft, and some of the fly-by-wire technology needed to stabilize the vehicle so that a sim-ple ecological mental model of the flying task can be implemented. We will discuss the requirements for a stability augmentation system that must be developed to support our simple pilot input model, and also present design guidelines and requirements based on a pilot input and management model. Finally, our ap-proach to vehicle development will involve considerable operator testing and evaluation: improving pilot model, inceptors, displays and also work on a plan for how a UAM vehicle can be integrated with terminal area air traffic control airspace with minimal impact on controller workload.

UAM↗

NASA NTRS1984

A numerical weather prediction system designed to simulate atmospheric downburst phenomena

It is pointed out that an increase in the understanding of weather-related aircraft accidents can save hundreds of human lives and million of dollars. A better understanding regarding the interaction between aircraft operation and severe weather conditions can be obtained with the aid of flight simulator facilities. It is shown that numerical weather modeling is one of the most precise and cost-effective inputs for flight simulators in the long run. A comprehensive weather modeling system is being developed for the simulation of different scales of atmospheric phenomena. The modeling system utilizes two numerical weather models, including the Mesoscale Atmospheric Simulation system, and the Terminal Area Simulation System.

Chuang, S.↗

NASA NTRS1991

Acquisition and improvement of human motor skills: Learning through observation and practice

Skilled movement is an integral part of the human existence. A better understanding of motor skills and their development is a prerequisite to the construction of truly flexible intelligent agents. We present MAEANDER, a computational model of human motor behavior, that uniformly addresses both the acquisition of skills through observation and the improvement of skills through practice. MAEANDER consists of a sensory-effector interface, a memory of movements, and a set of performance and learning mechanisms that let it recognize and generate motor skills. The system initially acquires such skills by observing movements performed by another agent and constructing a concept hierarchy. Given a stored motor skill in memory, MAEANDER will cause an effector to behave appropriately. All learning involves changing the hierarchical memory of skill concepts to more closely correspond to either observed experience or to desired behaviors. We evaluated MAEANDER empirically with respect to how well it acquires and improves both artificial movement types and handwritten script letters from the alphabet. We also evaluate MAEANDER as a psychological model by comparing its behavior to robust phenomena in humans and by considering the richness of the predictions it makes.

Iba, Wayne↗

NASA NTRSDate not supplied

Supportability Concepts for Crewed Deep Space Exploration

Supportability—defined as the set of system characteristics that influence the logistics and support required to enable safe and effective operations—will be a much larger driver of mass, risk, and crew time for future human space exploration due to the more challenging mission context. For Mars, systems must operate in a logistically isolated environment for much longer durations than previous missions, which results in a higher probability of system failure and therefore an increased need for maintenance or contingency options. Mars missions also lack access to quick aborts, which increases the consequences of an unrecoverable system failure. Together, this higher likelihood and consequence of failure results in an increase in supportability-related risk. Supportability analysis is an important part of systems development that helps designers better understand the impacts of system and mission decisions on risk, mass, and crew time. The real-world processes that drive maintenance requirements and other supportability-related characteristics are probabilistic, and therefore they require different conceptual approaches and models than are used for more deterministic aspects of space systems. This paper provides an overview of supportability analysis, addresses key concepts, and provides examples of how supportability analysis can be incorporated into system development. Specifically, system supportability involves stochastic processes, and therefore must be evaluated using probabilistic models. These models can be used to perform sensitivity analysis even if system characteristics are not yet fully defined. Failure rates cannot be measured directly, but tests provide valuable data that can help refine those estimates. Human spaceflight architectures are complex, and exhibit coupled behavior that should be examined with integrated systems analysis that includes an assessment of supportability.

Supportability↗

NASA NTRSDate not supplied

Supportability Concepts for Crewed Deep Space Exploration

Supportability↗