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At least 1,459 records · Page 81

26th International Symposium on Plant Lipids

The 2024 International Symposium on Plant Lipids (ISPL) successfully advanced scientific knowledge in plant lipid biology by presenting new discoveries in lipid metabolism, membrane structure and function, lipid signaling, and biotechnology. The symposium fostered professional development for early-career scientists through oral and poster presentation opportunities, lightning talks, and networking events. It promoted the exchange of new technologies, including advances in mass spectrometry, metabolic modeling, and synthetic biology, that will accelerate research across plant biology and related fields. ISPL also strengthened international collaborations, drawing 220 participants from 15 countries across four continents, and established a platform for ongoing scientific exchange and community-building within the global plant lipid research community.

59 BASIC BIOLOGICAL SCIENCES↗

Targeting a cell surface vitamin D receptor on tumor-associated macrophages in triple-negative breast cancer

Triple-negative breast cancer (TNBC) is an aggressive tumor with limited treatment options and poor prognosis. We applied the in vivo phage display technology to isolate peptides homing to the immunosuppressive cellular microenvironment of TNBC as a strategy for non-malignant target discovery. We identified a cyclic peptide (CSSTRESAC) that specifically binds to a vitamin D receptor, protein disulfide-isomerase A3 (PDIA3) expressed on the cell surface of tumor-associated macrophages (TAM), and targets breast cancer in syngeneic TNBC, non-TNBC xenograft, and transgenic mouse models. Systemic administration of CSSTRESAC to TNBC-bearing mice shifted the cytokine profile toward an antitumor immune response and delayed tumor growth. Moreover, CSSTRESAC enabled ligand-directed theranostic delivery to tumors and a mathematical model confirmed our experimental findings. Finally, in silico analysis showed PDIA3-expressing TAM in TNBC patients. This work uncovers a functional interplay between a cell surface vitamin D receptor in TAM and antitumor immune response that could be therapeutically exploited.

59 BASIC BIOLOGICAL SCIENCES↗

High Voltage Hall Accelerator Propulsion System Development for NASA Science Missions

NASA Science Mission Directorates In-Space Propulsion Technology Program is sponsoring the development of a 3.8 kW-class engineering development unit Hall thruster for implementation in NASA science and exploration missions. NASA Glenn Research Center and Aerojet are developing a high fidelity high voltage Hall accelerator (HiVHAc) thruster that can achieve specific impulse magnitudes greater than 2,700 seconds and xenon throughput capability in excess of 300 kilograms. Performance, plume mappings, thermal characterization, and vibration tests of the HiVHAc engineering development unit thruster have been performed. In addition, the HiVHAc project is also pursuing the development of a power processing unit (PPU) and xenon feed system (XFS) for integration with the HiVHAc engineering development unit thruster. Colorado Power Electronics and NASA Glenn Research Center have tested a brassboard PPU for more than 1,500 hours in a vacuum environment, and a new brassboard and engineering model PPU units are under development. VACCO Industries developed a xenon flow control module which has undergone qualification testing and will be integrated with the HiVHAc thruster extended duration tests. Finally, recent mission studies have shown that the HiVHAc propulsion system has sufficient performance for four Discovery- and two New Frontiers-class NASA design reference missions.

Kamhawi, Hani↗

Application of a new X-ray reflection model to V1223 Sagittarii

In intermediate polars (IPs), the intrinsic thermal emissions from white dwarfs (WDs) have typically been studied. Few reports have analysed X-ray reflections from WDs. We recently developed an elaborate IP-reflection spectral model. Herein, we report the first application of a reflection model with an IP thermal model to the spectra of the brightest typical IP V1223 Sagittarii observed by the Suzaku and Nuclear Spectroscopic Telescope Array satellites. The model reasonably reproduces the spectra within the range of 5–78 keV and estimates the WD mass as 0.92 ± 0.02 Mꙩ. The WD mass estimated by the proposed model is consistent with that measured using an active galactic nucleus reflection model and a partial covering absorption model. However, the choice of incorrect parameter values, such as an unsuitable fitting energy band and an incorrect metal abundance, was found to introduce systematic errors (e.g. ≲0.2 Mꙩ in the WD mass) in the WD mass measurement. Our spin-phase-resolved analysis resulted in discoveries regarding the modulations of the equivalent width of the fluorescent iron K α line and the angle between the post-shock accretion column and the line of sight (viewing angle). The viewing angle anticorrelates approximately with the X-ray flux and has average and semi-amplitude values of 55° and 7°, respectively, which points towards two WD spin axis angles from the line of sight of 55° and 7°, respectively. Both estimated spin axis angles are different from the reported system inclination of 24°.

Takayuki Hayashi↗

A Community Energy Operations and Planning System: Concept, Use cases, Metrics, and Benefits

Community and city leaders are interested in achieving sustainability goals, providing resilient energy infrastructure, and improving economic competitiveness. Community-level data acquisition and analysis can provide energy and associated benefits that are not possible at the single building level. However, there is a lack of organizational structure, common semantic data models, interoperable systems, and methods to support data-driven decision-making for community-scale energy supply and demand systems. We explored the need and opportunity for a Community Energy Operations and Planning System (Community EOPS), a potential data exchange platform. We conducted “customer discovery” interviews, and reviewed literature, public tools, and technology platforms to identify key energy data “users” and use cases in communities. The key users of the Community EOPS could be developers of mixed-use districts, corporate, defense and university campus energy managers, and city managers of cities that own their energy utility. The value could be for community planning and reporting (for energy data-integrated land use planning and community infrastructure investments in microgrids, storage, district heating and cooling), energy efficiency (leveraging optimizations for community scale energy supply and demand), flexible load management (grid-edge load management to offset, shift, and flatten loads for multiple buildings and EV fleets), cost savings and revenue generation (participating in grid services), and social benefits such as energy resilience, equity, and awareness. We developed a conceptual Community EOPS architecture with recommendations for streamlined and prioritized data acquisition, sharing, and integration driven by prioritized use cases, common metrics, and actionable visualizations that can provide value to a community’s users.

Singh, Reshma↗

A new transient pulsar in the Small Magellanic Cloud with an unusual x-ray spectrum

This article reports the discovery of a luminous (3.5 x 10(exp 37) ergs/sec over the 0.2 to 2 keV band) transient X-ray pulsar in the Small Magellanic Cloud (SMC) with an extremely soft component to its X-ray spectrum. This is the first time that a spectrum of this type has been seen in this class of X-ray source. The pulse period is 2.7632 s, and the pulse modulation appears to vary with energy from nearly unpulsed in the low-energy band of the ROSAT Position Sensitive Proportional Counter (PSPC) (0.07 to 0.4 keV) to about 50% in the high-energy band (1.0 to 2.4 keV). The object, RX J0059.2-7138, also shows flickering variability in its X-ray emission on timescales of 50 to 100s. The pulse-phase-averaged PSPC X-ray spectrum can be well described by a two-component source model seen through an absorbing column density of approximately 10(exp 21) atoms cm(exp -2). One spectral component is a power law with photon index 2.4. The other component is significantly softer and can be described by either a steeply falling power law or a blackbody with a temperature KT(sub BB) approximately 35 eV. Ths component is transient, but evidently upulsed, and, for the blackbody model fits, requires a large bolometric luminosity: near, or even several times greater than, the Eddington luminosity for a 1.4 solar mass object. When these characteristics of its soft emission are considered, RX J0059.2-7138 appears quite similar to other X-ray sources in the magellanic Clouds, such as CAL 83, CAL 87, and RX J0527.8-6954, which show only extreme ultrasoft (EUS) X-ray spectra. The discovery of RX J0059.2-7138, a probably high-mass X-ray binary, clearly indicates that EUS spectra may arise from accretion-powered neutron-star X-ray sources. This result lends support to the idea that some of the 'pure' EUS sources may be shrouded low-mass X-ray binaries rather than accreting white dwarfs.

Hughes, John P.↗

A 400-Solar-Mass Black Hole in the Galaxy M82

M82 X-1, the brightest X-ray source in the galaxy M82, has been thought to be an intermediate-mass black hole (100 to 10,000 solar masses) because of its extremely high luminosity and variability characteristics, although some models suggest that its mass may be only about 20 solar masses. The previous mass estimates were based on scaling relations that use low-frequency characteristic timescales which have large intrinsic uncertainties. For stellar-mass black holes, we know that the high-frequency quasi-periodic oscillations (100–450 hertz) in the X-ray emission that occur in a 3:2 frequency ratio are stable and scale in frequency inversely with black hole mass with a reasonably small dispersion. The discovery of such stable oscillations thus potentially offers an alternative and less ambiguous means of mass determination for intermediate-mass black holes, but has hitherto not been realized. Here we report stable, twin-peak (3:2 frequency ratio) X-ray quasi-periodic oscillations from M82 X-1 at frequencies of 3.3260.06 hertz and 5.0760.06 hertz. Assuming that we can extrapolate the inverse-mass scaling that holds for stellar-mass black holes, we estimate the black hole mass of M82 X-1 to be 4286 105 solar masses. In addition, we can estimate the mass using the relativistic precession model, from which we get a value of 415663 solar masses.

Pasham, Dheeraj R.↗

Modeling the Skills and Practices of Scientists through an “All-Inclusive” Comparative Planetology Student Research Investigation

To effectively prepare the nation's future Science, Technology, Engineering, and Mathematics (STEM) workforce, students in today's classrooms need opportunities to engage in authentic experiences that model skills and practices used by STEM professionals. Relevant, real-world authentic research experiences allow students to behave as scientists as they model the process of science. This enables students to get a true sense of STEM-related professions and also allows them to develop the requisite knowledge, skills, curiosity, and creativity necessary for success in STEM careers. Providing professional development and opportunities to help teachers infuse research in the classroom is one of the primary goals of the Expedition Earth and Beyond (EEAB) program. EEAB, facilitated by the Astromaterials Research and Exploration Science (ARES) Directorate at the NASA Johnson Space Center, is an Earth and planetary science education program designed to inspire, engage, and educate teachers and students in grades 5-12 by getting them actively involved with exploration, discovery, and the process of science. The program combines the expertise of scientists and educators to ensure the professional development provided to classroom teachers is scientifically valid and also recognizes classroom constraints. For many teachers, facilitating research in the classroom can be challenging. In addition to addressing required academic standards and dealing with time constraints, challenges include structuring a research investigation the entire class can successfully complete. To build educator confidence, foster positive classroom research experiences, and enable teachers to help students model the skills and practices of scientists, EEAB has created an "allinclusive" comparative planetology research investigation activity. This activity addresses academic standards while recognizing students (and teachers) potentially lack experience with scientific practices involved in conducting research. Designed as an entry level research engagement investigation, the activity introduces, illustrates, and teaches the skills involved in each step of the research process. Students use astronaut photos, provided through the ARES Crew Earth Observations (CEO) payload on the International Space Station (ISS) as well as remote sensing imagery of other planetary worlds. By including all the necessary tools to complete the investigation, students can focus on gaining experience in the process of science. Additionally, students are able to extend their experience of modeling the skills and practices of scientists through the opportunity to request new data of Earth from the ISS. Professional development offered through in-person and webinar trainings, along with the resources provided, enable educators to gain first-hand experience implementing a structured research investigation in the classroom. Through data and feedback collected from teachers, this type of "all-inclusive" investigation activity aims to become a model that can be utilized for other research topics and STEM disciplines.

Graff, Paige↗

SOMAS: a platform for data-driven material discovery in redox flow battery development

Abstract Aqueous organic redox flow batteries offer an environmentally benign, tunable, and safe route to large-scale energy storage. The energy density is one of the key performance parameters of organic redox flow batteries, which critically depends on the solubility of the redox-active molecule in water. Prediction of aqueous solubility remains a challenge in chemistry. Recently, machine learning models have been developed for molecular properties prediction in chemistry and material science. The fidelity of a machine learning model critically depends on the diversity, accuracy, and abundancy of the training datasets. We build a comprehensive open access organic molecular database “Solubility of Organic Molecules in Aqueous Solution” (SOMAS) containing about 12,000 molecules that covers wider chemical and solubility regimes suitable for aqueous organic redox flow battery development efforts. In addition to experimental solubility, we also provide eight distinctive quantum descriptors including optimized geometry derived from high-throughput density functional theory calculations along with six molecular descriptors for each molecule. SOMAS builds a critical foundation for future efforts in artificial intelligence-based solubility prediction models.

25 ENERGY STORAGE↗

Intermittent Defect Fluctuations in Oxide Heterostructures

Abstract The heterogeneous nature, local presence, and dynamic evolution of defects typically govern the ionic and electronic properties of a wide variety of functional materials. While the last 50 years have seen considerable efforts into development of new methods to identify the nature of defects in complex materials, such as the perovskite oxides, very little is known about defect dynamics and their influence on the functionality of a material. Here, the discovery of the intermittent behavior of point defects (oxygen vacancies) in oxide heterostructures employing X‐ray photon correlation spectroscopy is reported. Local fluctuations between two ordered phases in strained SrCoO x with different degrees of stability of the oxygen vacancies are observed. Ab‐initio‐informed phase‐field modeling reveals that fluctuations between the competing ordered phases are modulated by the oxygen ion/vacancy interaction energy and epitaxial strain. The results demonstrate how defect dynamics, evidenced by measurement and modeling of their temporal fluctuations, give rise to stochastic properties that now can be fully characterized using coherent X‐rays, coupled for the first time to multiscale modeling in functional complex oxide heterostructures. The study and its findings open new avenues for engineering the dynamical response of functional materials used in neuromorphic and electrochemical applications.

36 MATERIALS SCIENCE↗

Discovery of a weak topological insulating state and van Hove singularity in triclinic RhBi2

Abstract Time reversal symmetric (TRS) invariant topological insulators (TIs) fullfil a paradigmatic role in the field of topological materials, standing at the origin of its development. Apart from TRS protected strong TIs, it was realized early on that more confounding weak topological insulators (WTI) exist. WTIs depend on translational symmetry and exhibit topological surface states only in certain directions making it significantly more difficult to match the experimental success of strong TIs. We here report on the discovery of a WTI state in RhBi 2 that belongs to the optimal space group P $$\bar{1}$$ 1 ¯ , which is the only space group where symmetry indicated eigenvalues enumerate all possible invariants due to absence of additional constraining crystalline symmetries. Our ARPES, DFT calculations, and effective model reveal topological surface states with saddle points that are located in the vicinity of a Dirac point resulting in a van Hove singularity (VHS) along the (100) direction close to the Fermi energy ( E F ). Due to the combination of exotic features, this material offers great potential as a material platform for novel quantum effects.

36 MATERIALS SCIENCE↗

A Free-floating or Wide-orbit Planet in the Microlensing Event OGLE-2019-BLG-0551

High-cadence observations of the Galactic bulge by the microlensing surveys led to the discovery of a handful of extremely short-timescale microlensing events that can be attributed to free-floating or wide-orbit planets. Here, we report the discovery of another strong free-floating planet candidate, which was found from the analysis of the gravitational microlensing event OGLE-2019-BLG-0551. The light curve of the event is characterized by a very short duration (≲3 days) and a very small amplitude (≲0.1 mag). From modeling of the light curve, we find that the Einstein timescale, t{sub E}=0.381±0.017 day, is much shorter, and the angular Einstein radius, θ{sub E}=4.35±0.34 μas, is much smaller than those of typical lensing events produced by stellar-mass lenses (t{sub E}∼20 days, θ{sub E}∼0.3 mas), indicating that the lens is very likely to be a planetary-mass object. We conduct an extensive search for possible signatures of a companion star in the light curve of the event, finding no significant evidence for the putative host star. For the first time, we also demonstrate that the angular Einstein radius of the lens does not depend on blending in the low-magnification events with strong finite source effects.

79 ASTRONOMY AND ASTROPHYSICS↗

High-velocity emission in young supernova remnants: SN 1006 and SN 1572

The paper reports the discovery of broad H-alpha emission from the SN 1006 remnant with a FWHM velocity of 2600 + or - 100 km/s. This emission is similar to that seen in the remnant of SN 1572 which has a FWHM for H-alpha of 1800 km/s. The nonradiative model was used to interpret the line widths and the derived shock velocity was compared with proper motion measurements to derive distances of 1.4-2.1 kpc to SN 1006 and 2.0-2.8 kpc to SN 1572.

Kirshner, Robert↗

Diffuse X-ray emission from the NGC 2300 group of galaxies - Implications for dark matter and galaxy evolution in small groups

The discovery of diffuse X-ray emission from the NGC 2300 group of galaxies using the ROSAT Position Sensitive Proportional Counter is reported. The gas distributions is roughly symmetric and extends to a radius of at least 0.2/h(50) Mpc. A Raymond-Smith hot plasma model provides an excellent fit the X-ray spectrum with a best-fit value temperature of 0.9 + -/15 or - 0.14 keV and abundance 0.06 + 0/.12 or - 0.05 solar. The assumption of gravitational confinement leads to a total mass of the group of 3.0 + 0.4 or - 0.5 x 10 exp 13 solar. Baryons can reasonably account for 4 percent of this mass, and errors could push this number not higher than 10-15 percent. This is one of the strongest pieces of evidence that dark matter dominates small groups such as this one. The intragroup medium in this system has the lowest metal abundance yet found in diffuse gas in a group or cluster.

Mulchaey, John S.↗

Prospero - A tool for organizing Internet resources

This article describes Prospero, a distributed file system based on the Virtual System Model. Prospero provides tools to help users organize Internet resources. These tools allow users to construct customized views of available resources, while taking advantage of the structure imposed by others. Prospero provides a framework that can tie together various indexing services producing the fabric on which resource discovery techniques can be applied.

Neuman, B. C.↗

Polar and Non-Polar Layers on Mars: A Single Mechanism for Formation?

The recent discovery of vast quantities of near-subsurface ice in both polar regions of Mars by the Mars Odyssey Gamma Ray Spectrometer (GRS) has presented us with an interesting quandary. On one hand, these deposits, found poleward of 60 deg in both hemispheres, are consistent with thermal models suggesting ice will be best protected in these regions during periods of high obliquity. On the other hand, the current paradigm regarding the placement of these deposits, i.e., diffusive deposition of water vapor, appears to be inconsistent with the large volume mixing ratios (approx. 90%) inferred from the GRS data. This incongruity argues that diffusion alone cannot be the primary mechanism for the creation of these reservoirs, and that an alternate, large-scale process should be considered.

Mischna, M. A.↗

Discovery of the Red-Skewed K-alpha Iron Line in Cyg X-2 with Suzaku

We report on the Suzaku observation of neutron star low-mass X-ray binary Cygnus X-2 which reveals strong iron K-alpha emission line. The line profile shows a prominent red wing extending down to 4 keV. This discovery increases the number of neutron star sources where red-skewed iron lines were observed and strongly suggests that this phenomenon is common not only in black holes but also in other types of compact objects. We examine the line profile by fitting it with the model which attributes its production to the relativistic effects due to disk reflection of X-ray radiation. We also apply an alternative model where the red wing is a result of down-scattering effect of the first order with respect to electron velocity in the wind outflow. Both models describe adequately the observed line profile. However, the X-ray variability in a state similar to that in the Suzaku observation which we establish by analysing RXTE observation favors the wind origin of the line formation.

Shaposhnikov, Nikolai↗