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At least 1,459 records · Page 81

Titan Submarine: Exploring The Depths of Kraken Mare

The conceptual design of a submarine for Saturn's moon Titan was a funded NASA Innovative Advanced Concepts (NIAC) Phase I for 2014. The effort investigated what science a submarine for Titan's liquid hydrocarbon approximately 93 Kelvin (-180 degrees Centigrade) seas might accomplish and what that submarine might look like. Focusing on a flagship class science system (approximately100 kilograms) it was found that a submersible platform can accomplish extensive and exciting science both above and below the surface of the Kraken Mare The submerged science includes mapping using side looking sonar, imaging and spectroscopy of the sea at all depths, as well as sampling of the sea's bottom and shallow shoreline. While surfaced the submarine will not only sense weather conditions (including the interaction between the liquid and atmosphere) but also image the shoreline, as much as 2 kilometers inland. This imaging requirement pushed the landing date to Titan's next summer period (approximately 2047) to allow for continuous lighted conditions, as well as direct-to-Earth (DTE) communication, avoiding the need for a separate relay orbiter spacecraft. Submerged and surfaced investigation are key to understanding both the hydrological cycle of Titan as well as gather hints to how life may have begun on Earth using liquid/sediment/chemical interactions. An estimated 25 megabits of data per day would be generated by the various science packages. Most of the science packages (electronics at least) can be safely kept inside the submarine pressure vessel and warmed by the isotope power system. This paper discusses the results of Phase I as well as the plans for Phase II.

submarine↗

Sixth Annual NASA Ames Space Science and Astrobiology Jamboree

Welcome to the Sixth Annual NASA Ames Research Center, Space Science and Astrobiology Jamboree at NASA Ames Research Center (ARC). The Space Science and Astrobiology Division consists of over 60 Civil Servants, with more than 120 Cooperative Agreement Research Scientists, Post-Doctoral Fellows, Science Support Contractors, Visiting Scientists, and many other Research Associates. Within the Division there is engagement in scientific investigations over a breadth of disciplines including Astrobiology, Astrophysics, Exobiology, Exoplanets, Planetary Systems Science, and many more. The Division's personnel support NASA spacecraft missions (current and planned), including SOFIA, K2, MSL, New Horizons, JWST, WFIRST, and others. Our top-notch science research staff is spread amongst three branches in five buildings at ARC. Naturally, it can thus be difficult to remain abreast of what fellow scientific researchers pursue actively, and then what may present and/or offer regarding inter-Branch, intra-Division future collaborative efforts. In organizing this annual jamboree, the goals are to offer a wholesome, one-venue opportunity to sense the active scientific research and spacecraft mission involvement within the Division; and to facilitate communication and collaboration amongst our research scientists. Annually, the Division honors one senior research scientist with a Pollack Lecture, and one early career research scientist with an Outstanding Early Career Space Scientist Lecture. For the Pollack Lecture, the honor is bestowed upon a senior researcher who has made significant contributions within any area of research aligned with space science and/or astrobiology. This year we are pleased to honor Linda Jahnke. With the Early Career Lecture, the honor is bestowed upon an early-career researcher who has substantially demonstrated great promise for significant contributions within space science, astrobiology, and/or, in support of spacecraft missions addressing such disciplines. This year we are pleased to honor Amanda Cook. We hope that you will make time to join us for the day in meeting fellow Division members, expanding knowledge of our activities, and creating new collaborations within the Space Science and Astrobiology Division.

Hollingsworth, Jeffery↗

Phase 1 Final Report: Titan Submarine

The conceptual design of a submarine for Saturn's moon Titan was a funded NASA Innovative Advanced Concepts (NIAC) Phase 1 for 2014. The proposal stated the desire to investigate what science a submarine for Titan's liquid hydrocarbon seas might accomplish and what that submarine might look like. Focusing on a flagship class science system (100 kg), it was found that a submersible platform can accomplish extensive science both above and below the surface of the Kraken Mare. Submerged science includes mapping using side-looking sonar, imaging and spectroscopy of the lake, as well as sampling of the lake's bottom and shallow shoreline. While surfaced, the submarine will not only sense weather conditions (including the interaction between the liquid and atmosphere) but also image the shoreline, as much as 2 km inland. This imaging requirement pushed the landing date to Titan's next summer period (2047) to allow for lighted conditions, as well as direct-to-Earth communication, avoiding the need for a separate relay orbiter spacecraft. Submerged and surfaced investigation are key to understanding both the hydrological cycle of Titan as well as gather hints to how life may have begun on Earth using liquid, sediment, and chemical interactions. An estimated 25 Mb of data per day would be generated by the various science packages. Most of the science packages (electronics at least) can be safely kept inside the submarine pressure vessel and warmed by the isotope power system.The baseline 90-day mission would be to sail submerged and surfaced around and through Kraken Mare investigating the shoreline and inlets to evaluate the sedimentary interaction both on the surface and then below. Depths of Kraken have yet to be sensed (Ligeia to the north is thought to be 200 m (656 ft) deep), but a maximum depth of 1,000 m (3,281 ft) for Kraken Mare was assumed for the design). The sub would spend 20 d at the interface between Kraken Mare and Ligeia Mare for clues to the drainage of liquid methane into the currently predicted predominantly ethane Kraken Mare. During an extended ninety-day mission, it would transit the throat of Kraken (now Seldon Fretum) and perform similar explorations in other areas of Kraken Mare. Once this half year of exploration is completed the submarine could be tasked to revisit points of interest and perhaps do a complete sonar mapping of the seas. All in all, the submarine could explore over 3,000 km (1,864 mi) in its primary mission at an average speed of 0.3 meters per second.

Titan↗

Climate Extremes and Risks: Links Between Climate Science and Decision-Making

The World Climate Research Programme (WCRP) envisions a future where actionable climate information is universally accessible, supporting decision makers in preparing for and responding to climate change. In this perspective, we advocate for enhancing links between climate science and decision-making through a better and more decision-relevant understanding of climate impacts. The proposed framework comprises three pillars: climate science, impact science, and decision-making, focusing on generating seamless climate information from sub-seasonal, seasonal, decadal to century timescales informed by observed climate events and their impacts. The link between climate science and decision-making has strengthened in recent years, partly owing to undeniable impacts arising from disastrous weather extremes. Enhancing decision-relevant understanding involves utilizing lessons from past extreme events and implementing impact-based early warning systems to improve resilience. Integrated risk assessment and management require a comprehensive approach that encompasses good knowledge about possible impacts, hazard identification, monitoring, and communication of risks while acknowledging uncertainties inherent in climate predictions and projections, but not letting the uncertainty lead to decision paralysis. The importance of data accessibility, especially in the Global South, underscores the need for better coordination and resource allocation. Strategic frameworks should aim to enhance impact-related and open-access climate services around the world. Continuous improvements in predictive modeling and observational data are critical, as is ensuring that climate science remains relevant to decision makers locally and globally. Ultimately, fostering stronger collaborations and dedicated investments to process and tailor climate data will enhance societal preparedness, enabling communities to navigate the complexities of a changing climate effectively.

climate extremes↗

INCREASING THE TRANSPARENCY AND REPRODUCIBILITY OF SPACE RADIATION SCIENCE: THE RADIATION BIOLOGY ONTOLOGY

Among the primary objectives of the Open/Open-Source Science paradigm are making scientific investigation data transparent and results reproducible [1], objectives shared by the FAIR principles [2]. To accomplish this, the conceptual framework that includes all the investigation objects needs to be accurately captured and communicated to all data consumers. A large part of this requires using metadata standards to annotate data collected. These standards should be readily accessible, informed by scientific community consensus and sufficiently specific to encompass all of the important aspects of the investigation. Starting in 2020 we have been co-leading an open consortium to develop a new metadata standard, the Radiation Biology Ontology (RBO), through the Open Biological and Biomedical Ontologies (OBO) Foundry [3]. We began by transforming many of the terms from the National Council on Radiation Protection and Measurement into concepts that can be formally related to existing OBO Foundry classes or attributes. We then identified and imported into the RBO existing OBO Foundry classes that have obvious relevance for radiation biomedicine (for example, concepts from the Environment Ontology that describe radiative processes, and concepts from the Gene Ontology dealing with molecular and cellular responses to radiation). Finally, we scrutinized datasets from investigations of radiation effects held in NASA GeneLab and LSDA repositories and added additional classes, instances, and attributes into the RBO that should be used to annotate these data. We developed the RBO using the open-source tools of GitHub and publish the RBO periodically through the NIH/NCBI BioPortal website, so systems worldwide can leverage the knowledge it contains [4]. This initial phase of concept modeling has yielded an RBO that at present has more than 300 declared concepts, with more than 3500 additional concepts imported from other OBO Foundry ontologies. While this first phase has focused on concepts for annotating samples, environments, exposures, and measurements, the next phase will center on supporting annotation of results and findings, such as concept models of molecular, cellular and tissue effects. The value of the RBO will be determined in part by our ability to engage the community in its development, and we have established a Radiobiology Informatics Consortium with unrestricted membership as the owner of the RBO in order to encourage investigators, system owners and other to join in this effort. Anyone can report issues or request new concept modeling or other features directly on GitHub. By using the BioPortal application programming interface, systems can pose dynamic queries to the latest version of the RBO for information on individual classes or entire hierarchies; this design eliminates the need for systems to be updated in order to use newer versions of the RBO. We hope to contribute to the advancement of open radiobiological science through the continued, open development of the RBO, that will provide more precise, machine-interpretable descriptions of investigations, as well as support data meta-analysis through machine learning or other artificial intelligence methods. REFERENCES [1] Open science in space. Nature Medicine, 2021. 27(9): p. 1485-1485. [2] Wilkinson, M.D., et al., The FAIR Guiding Principles for scientific data management and stewardship. Sci Data, 2016. 3: p. 160018. [3] Smith, B., et al., The OBO Foundry: coordinated evolution of ontologies to support biomedical data integration. Nat Biotechnol, 2007. 25(11): p. 1251-5. [4] Whetzel, P.L., et al., BioPortal: enhanced functionality via new Web services from the National Center for Biomedical Ontology to access and use ontologies in software applications. Nucleic Acids Res, 2011. 39(Web Server issue): p. W541-5.

informatics↗

INCREASING THE TRANSPARENCY AND REPRODUCIBILITY OF SPACE RADIATION SCIENCE: THE RADIATION BIOLOGY ONTOLOGY

Among the primary objectives of the Open/Open-Source Science paradigm are making scientific investigation data transparent and results reproducible [1], objectives shared by the FAIR principles [2]. To accomplish this, the conceptual framework that includes all the investigation objects needs to be accurately captured and communicated to all data consumers. A large part of this requires using metadata standards to annotate data collected. These standards should be readily accessible, informed by scientific community consensus and sufficiently specific to encompass all of the important aspects of the investigation. Starting in 2020 we have been co-leading an open consortium to develop a new metadata standard, the Radiation Biology Ontology (RBO), through the Open Biological and Biomedical Ontologies (OBO) Foundry [3]. We began by transforming many of the terms from the National Council on Radiation Protection and Measurement into concepts that can be formally related to existing OBO Foundry classes or attributes. We then identified and imported into the RBO existing OBO Foundry classes that have obvious relevance for radiation biomedicine (for example, concepts from the Environment Ontology that describe radiative processes, and concepts from the Gene Ontology dealing with molecular and cellular responses to radiation). Finally, we scrutinized datasets from investigations of radiation effects held in NASA GeneLab and LSDA repositories and added additional classes, instances, and attributes into the RBO that should be used to annotate these data. We developed the RBO using the open-source tools of GitHub and publish the RBO periodically through the NIH/NCBI BioPortal website, so systems worldwide can leverage the knowledge it contains [4]. This initial phase of concept modeling has yielded an RBO that at present has more than 300 declared concepts, with more than 3500 additional concepts imported from other OBO Foundry ontologies. While this first phase has focused on concepts for annotating samples, environments, exposures, and measurements, the next phase will center on supporting annotation of results and findings, such as concept models of molecular, cellular and tissue effects. The value of the RBO will be determined in part by our ability to engage the community in its development, and we have established a Radiobiology Informatics Consortium with unrestricted membership as the owner of the RBO in order to encourage investigators, system owners and other to join in this effort. Anyone can report issues or request new concept modeling or other features directly on GitHub. By using the BioPortal application programming interface, systems can pose dynamic queries to the latest version of the RBO for information on individual classes or entire hierarchies; this design eliminates the need for systems to be updated in order to use newer versions of the RBO. We hope to contribute to the advancement of open radiobiological science through the continued, open development of the RBO, that will provide more precise, machine-interpretable descriptions of investigations, as well as support data meta-analysis through machine learning or other artificial intelligence methods.

knowledge↗

Assessment methods for determining small changes in hearing performance over time

Although the behavioral pure-tone threshold audiogram is considered the gold standard for quantifying hearing loss, assessment of speech understanding, especially in noise, is more relevant to quality of life but is only partly related to the audiogram. Metrics of speech understanding in noise are therefore an attractive target for assessing hearing over time. However, speech-in-noise assessments have more potential sources of variability than pure-tone threshold measures, making it a challenge to obtain results reliable enough to detect small changes in performance. Here, this review examines the benefits and limitations of speech-understanding metrics and their application to longitudinal hearing assessment, and identifies potential sources of variability, including learning effects, differences in item difficulty, and between- and within-individual variations in effort and motivation. We conclude by recommending the integration of non-speech auditory tests, which provide information about aspects of auditory health that have reduced variability and fewer central influences than speech tests, in parallel with the traditional audiogram and speech-based assessments.

60 APPLIED LIFE SCIENCES↗

The deep space network, volume 13

The objectives, functions, and organization of the Deep Space Network are summarized. The deep space instrumentation facility, the ground communications facility, and the network control system are described. Other areas reported include: Helios Mission support, DSN support of the Mariner Mars 1971 extended mission, Mariner Venus/Mercury 1973 mission support, Viking mission support, radio science, tracking and ground-based navigation, network control and data processing, and deep space stations.

Source record↗

Design of the MESUR/pathfinder microrover

The use of unmanned robotic vehicles to assist in the exploration of Mars and other planets has been of interest to the National Aeronautics and Space Administration (NASA) for several decades and has been the focus of an ongoing research program at the Jet Propulsion Laboratory (JPL) for a similar period of time. As a result of these research activities, JPL is in the process of designing and building a small (7-9 kg) microrover to be flown aboard the Mars Environmental Survey Mission (MESUR)/Pathfinder spacecraft, which is tentatively to be launched to Mars in late 1997. The microrover will perform a variety of technology experiments designed to provide information critical to the design of future planetary rovers. In addition, the microrover will perform several science and lander related experiments using specialized onboard instruments. To enable the microrover to perform these experiments at selected target areas and at the same time deal with the long time delays (and limited communications bandwidth), a control/navigation approach combining the use of operator-designated waypoints and onboard behavior control has been adopted. The design of the MESUR/Pathfinder microrover and the overall manner in which it is controlled are described herein.

Stone, Henry W.↗

SolSTUS: Solar Source Thermal Upper Stage

This paper was written by members of the Utah State University (USU) Space Systems Design class, fall quarter 1993. The class is funded by NASA and administered by the University Space Research Association (USRA). The focus of the class is to give students some experience in design of space systems and as a source of original ideas for NASA. This paper is a summary of the work done by members of the Space Systems Design class during the opening phase of the course. The class was divided into groups to work on different areas of the Solar Thermal Rocket (STR) booster in order to produce a design reference mission that would identify the key design issues. The design reference mission focused upon a small satellite mission to Mars. There are several critical components in a Solar Thermal Rocket. STR's produce a very low thrust, but have a high specific impulse, meaning that they take longer to reach the desired orbit, but use a lot less fuel in doing it. The complexity of the rocket is discussed in this paper. Some of the more critical design problems discussed are: (1) the structural and optical complexity of collecting and focusing sunlight onto a specific point, (2) long term storage of fuel (liquid hydrogen), (3) attitude control while thrusting in an elliptical orbit and orienting the mirrors to collect sunlight, and (4) power and communications for the rocket and it's internal systems. The design reference mission discussed here is a very general mission to Mars. A first order trajectory design has been done and a possible basic science payload for Mars has been suggested. This paper summarizes the design reference mission (DRM) formulated by the USU students during fall quarter and identifies major design challenges that will confront the design team during the next two quarters here at USU.

Source record↗

A NASA/University Joint Venture in Space Science (JOVE)

Most aspects of the JOVE program at Harding University were very successful. The number and quality of students interested in space science areas was increased due to the availability of support funds for JOVE scholars. Both physics faculty associated with the program have continued work in areas associated with the JOVE program. Several additional research grants for student research and scholarship support have been received from the Arkansas Space Grant Consortium since the termination of the JOVE program. The network connection established has been used extensively for educational and research purposes in connection with awarded grants and with science education at Harding University. The major unsuccessful area was in obtaining external funding in the area of solar physics in which Harding's JOVE program was working and in not more aggressively pursuing communication and cooperative effort with our JOVE mentor. This has resulted in all of the associated JOVE faculty no longer working in the solar physics area. The JOVE program has contributed significantly to the success of faculty programs in other areas that were fundable.

Source record↗

NASA Tech Briefs, December 2011

Topics covered include: 1) SNE Industrial Fieldbus Interface; 2) Composite Thermal Switch; 3) XMOS XC-2 Development Board for Mechanical Control and Data Collection; 4) Receiver Gain Modulation Circuit; 5) NEXUS Scalable and Distributed Next-Generation Avionics Bus for Space Missions; 6) Digital Interface Board to Control Phase and Amplitude of Four Channels; 7) CoNNeCT Baseband Processor Module; 8) Cryogenic 160-GHz MMIC Heterodyne Receiver Module; 9) Ka-Band, Multi-Gigabit-Per-Second Transceiver; 10) All-Solid-State 2.45-to-2.78-THz Source; 11) Onboard Interferometric SAR Processor for the Ka-Band Radar Interferometer (KaRIn); 12) Space Environments Testbed; 13) High-Performance 3D Articulated Robot Display; 14) Athena; 15) In Situ Surface Characterization; 16) Ndarts; 17) Cryo-Etched Black Silicon for Use as Optical Black; 18) Advanced CO2 Removal and Reduction System; 19) Correcting Thermal Deformations in an Active Composite Reflector; 20) Umbilical Deployment Device; 21) Space Mirror Alignment System; 22) Thermionic Power Cell To Harness Heat Energies for Geothermal Applications; 23) Graph Theory Roots of Spatial Operators for Kinematics and Dynamics; 24) Spacesuit Soft Upper Torso Sizing Systems; 25) Radiation Protection Using Single-Wall Carbon Nanotube Derivatives; 26) PMA-PhyloChip DNA Microarray to Elucidate Viable Microbial Community Structure; 27) Lidar Luminance Quantizer; 28) Distributed Capacitive Sensor for Sample Mass Measurement; 29) Base Flow Model Validation; 30) Minimum Landing Error Powered-Descent Guidance for Planetary Missions; 31) Framework for Integrating Science Data Processing Algorithms Into Process Control Systems; 32) Time Synchronization and Distribution Mechanisms for Space Networks; 33) Local Estimators for Spacecraft Formation Flying; 34) Software-Defined Radio for Space-to-Space Communications; 35) Reflective Occultation Mask for Evaluation of Occulter Designs for Planet Finding; and 36) Molecular Adsorber Coating

Source record↗

Communicating by Doppler: Detecting Spacecraft Dynamics During Critical Maneuvers

Communicating information from spacecraft in deep space utilizes sophisticated techniques of modulations onto a microwave signal carrier. Under most conditions, there is a high success rate of sending commands to the spacecraft and receiving science data acquired by on-board instruments along with health and status information. There are conditions, however, where the signal dynamics are too high and/or the received signal-to-noise ratio is below the receiver threshold. Under these conditions, often by design and sometimes as a result of planned or unplanned critical maneuvers, events (e.g., orbit insertion or descent and landing), safe mode, etc., it becomes highly critical but exceedingly challenging to receive information about the health and dynamical behavior of the spacecraft. The Deep Space Network, being a world-class instrument for Radio Science research, developed openloop receivers, called the Radio Science Receiver, designed to capture the raw incoming electromagnetic signals and associated noise for Radio Science experiments; post data capture digital signal processing extracts the signal carrier for scientific analysis. This receiver provides a high level of configuration flexibility and can be optimized for the various types of experiments. In addition to its scientific utility, it proved to be useful, and in some cases critical, for the support of missions during specific scenarios were the link budget is below the threshold of the tracking receiver to maintain lock or the frequency dynamics are faster than the limits of the tracking receiver. In these cases, the signal carrier is often detected only in the open-loop receiver to provide information on the specific behavior of the spacecraft from the carrier dynamics. This paper describes the utility of the system to support mission-critical events for the three cases of Cassini's Saturn orbit insertion, Huygens Titan landing, and Mars rovers landing.

radio science↗

Research Operations and Integration Flight Session – Always Sweat the Small Stuff

Human research routinely involves elaborate operations with substantial hardware setup, such as functional MRIs, CT scans, ultrasounds, exercise sessions, and cardiac evaluations. These conspicuous operations garner most of our attention and, understandably, resources, but the unsung heroes of spaceflight human research often get by with little fanfare. The collection of human samples and surveys is often just as much of a challenge in terms of both planning and logistics. The samples and surveys are often collected or completed by the crew autonomously, with little to no oversight from science support staff, which puts them the most at risk for data loss. The Research Operations and Integration team will host an interactive session with audience participation to demonstrate the importance of the written communications and instructions that are provided to the astronauts. During this hands-on session, ROI will walk through the challenges faced to ensure astronaut subjects can successfully collect all the various samples (e.g., saliva, fecal, urine, and blood) that the human research community needs. The format will be part lecture and part game show intended to provide both an enlightening and fun session. As we often instruct the crew: “Don’t forget to arrive fasted and bring a list of all the medications you’ve taken in the past week.”

Cherie Morgan Oubre↗

Deployable Propulsion and Power Systems for Solar System Exploration

NASA is developing thin-film based, deployable propulsion, power and communication systems for small spacecraft that could provide a revolutionary new capability allowing small spacecraft exploration of the solar system. The Near Earth Asteroid (NEA) Scout reconnaissance mission will demonstrate solar sail propulsion on a 6U CubeSat interplanetary spacecraft and lay the groundwork for their future use in deep space science and exploration missions. Solar sails use sunlight to propel vehicles through space by reflecting solar photons from a large, mirror-like sail made of a lightweight, highly reflective material. This continuous photon pressure provides propellantless thrust, allowing for very high delta V maneuvers on long-duration, deep space exploration. Since reflected light produces thrust, solar sails require no onboard propellant. The Lightweight Integrated Solar Array and Transceiver (LISA-T) is a launch stowed, orbit deployed array on which thin-film photovoltaic and antenna elements are embedded. Inherently, small satellites are limited in surface area, volume, and mass allocation; driving competition between power, communications, and GN&C (guidance navigation and control) subsystems. This restricts payload capability and limits the value of these low-cost satellites. LISA-T is addressing this issue, deploying large-area arrays from a reduced volume and mass envelope - greatly enhancing power generation and communications capabilities of small spacecraft. The NEA Scout mission, funded by NASA's Advanced Exploration Systems Program and managed by NASA MSFC, will use the solar sail as its primary propulsion system, allowing it to survey and image one or more NEA's of interest for possible future human exploration. NEA Scout uses a 6U cubesat (to be provided by NASA's Jet Propulsion Laboratory), an 86 sq m solar sail and will weigh less than 12 kilograms. NEA Scout will be launched on the first flight of the Space Launch System in 2018. Similar in concept to the NEA Scout solar sail, the LISA-T array is designed to fit into a very small volume and provide abundant power and omnidirectional communications in just about any deployment configuration. The technology is being proposed for flight validation as early as 2019 in a low earth orbit demonstration using a 3U cubesat, of which less than 1U will be devoted to the LISA-T power and propulsion system. By leveraging recent advancements in thin films, photovoltaics and miniaturized electronics, new mission-level capabilities will be enabled aboard lower-cost small spacecraft instead of their more expensive, traditional counterparts, enabling a new generation of frequent, inexpensive deep space missions.

Johnson, Les↗

All-silicon quantum light source by embedding an atomic emissive center in a nanophotonic cavity

Silicon is the most scalable optoelectronic material but has suffered from its inability to generate directly and efficiently classical or quantum light on-chip. Scaling and integration are the most fundamental challenges facing quantum science and technology. We report an all-silicon quantum light source based on a single atomic emissive center embedded in a silicon-based nanophotonic cavity. We observe a more than 30-fold enhancement of luminescence, a near-unity atom-cavity coupling efficiency, and an 8-fold acceleration of the emission from the all-silicon quantum emissive center. Our work opens immediate avenues for large-scale integrated cavity quantum electrodynamics and quantum light-matter interfaces with applications in quantum communication and networking, sensing, imaging, and computing.

36 MATERIALS SCIENCE↗

Programmable Aggregation of Artificial Cells with DNA Signals

Cell aggregation is a complex behavior, which is closely related to the viability, differentiation, and migration of cells. An effort to create synthetic analogs could lead to considerable advances in cell physiology and biophysics. Rendering and modulating such a dynamic artificial cell system require mechanisms for receiving, transducing, and transmitting intercellular signals, yet effective tools are limited at present. Here we construct synthetic cells from engineered lipids and show their programmable aggregation behaviors using DNA oligonucleotides as a signaling molecule. The artificial cells have transmembrane channels made of DNA origami that are used to recognize and process intercellular signals. We demonstrate that multiple small vesicles aggregate onto a giant vesicle after a transduction of external DNA signals by an intracellular enzyme, and that the small vesicles dissociate when receiving ‘release’ signals. Furthermore, this work provides new possibilities for building synthetic protocells capable of chemical communication and coordination.

59 BASIC BIOLOGICAL SCIENCES↗

Photonic time-crystalline behaviour mediated by phonon squeezing in T a 2 NiSe 5

Photonic time crystals refer to materials whose dielectric properties are periodic in time, analogous to a photonic crystal whose dielectric properties is periodic in space. Here, we theoretically investigate photonic time-crystalline behaviour initiated by optical excitation above the electronic gap of the excitonic insulator candidate Ta 2 NiSe 5 . We show that after electron photoexcitation, electron-phonon coupling leads to an unconventional squeezed phonon state, characterised by periodic oscillations of phonon fluctuations. Squeezing oscillations lead to photonic time crystalline behaviour. The key signature of the photonic time crystalline behaviour is terahertz (THz) amplification of reflectivity in a narrow frequency band. The theory is supported by experimental results on Ta 2 NiSe 5 where photoexcitation with short pulses leads to enhanced THz reflectivity with the predicted features. We explain the key mechanism leading to THz amplification in terms of a simplified electron-phonon Hamiltonian motivated by ab-initio DFT calculations. Our theory suggests that the pumped Ta 2 NiSe 5 is a gain medium, demonstrating that squeezed phonon noise may be used to create THz amplifiers in THz communication applications.

36 MATERIALS SCIENCE↗