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NASA NTRS1977

On the theory of solitary Rossby waves

The evolution of long, finite amplitude Rossby waves in a horizontally sheared zonal current is studied. The wave evolution is described by the Korteweg-de Vries equation or the modified Korteweg-de Vries equation depending on the atmospheric stratification. In either case, the cross-stream modal structure of these waves is given by the long-wave limit of the neutral eigensolutions of the barotropic stability equation. Both non-singular and singular eigensolutions are considered and the appropriate analysis is developed to yield a uniformly valid description of the motion in the critical-layer region where the wave speed matches the flow velocity. The analysis demonstrates that coherent, propagating, eddy structures can exist in stable shear flows and that these eddies have peculiar interaction properties quite distinct from the traditional views of turbulent motion.

Redekopp, L. G.↗

NASA NTRS1983

Measurement of acoustic modes and wall impedance in a turbofan exhaust duct

Acoustic measurements made with in-duct modal probes show how individual acoustic modes, as generated by fan/stator interaction, interact with a well-characterized liner. This measured attenuation provides a critical test for predicted attenuation as developed from the theoretical analysis of sound propagation in annular ducts with treatment and sheared flow. The primary investigations took place in the exhaust duct of a model fan mounted in an anechoic chamber. The results presented include induct attenuation, sound power attenuation as measured in the far field, and in-situ acoustic impedance measurements of the treated wall sections. Good theory/experiment agreement was found; the differences of treatment suppression between theory and measured values differed at most by 2.7 dB.

Fiske, G. H.↗

NASA NTRS1998

Development of a Probabilistic Dynamic Synthesis Method for the Analysis of Nondeterministic Structures

Accounting for the statistical geometric and material variability of structures in analysis has been a topic of considerable research for the last 30 years. The determination of quantifiable measures of statistical probability of a desired response variable, such as natural frequency, maximum displacement, or stress, to replace experience-based "safety factors" has been a primary goal of these studies. There are, however, several problems associated with their satisfactory application to realistic structures, such as bladed disks in turbomachinery. These include the accurate definition of the input random variables (rv's), the large size of the finite element models frequently used to simulate these structures, which makes even a single deterministic analysis expensive, and accurate generation of the cumulative distribution function (CDF) necessary to obtain the probability of the desired response variables. The research presented here applies a methodology called probabilistic dynamic synthesis (PDS) to solve these problems. The PDS method uses dynamic characteristics of substructures measured from modal test as the input rv's, rather than "primitive" rv's such as material or geometric uncertainties. These dynamic characteristics, which are the free-free eigenvalues, eigenvectors, and residual flexibility (RF), are readily measured and for many substructures, a reasonable sample set of these measurements can be obtained. The statistics for these rv's accurately account for the entire random character of the substructure. Using the RF method of component mode synthesis, these dynamic characteristics are used to generate reduced-size sample models of the substructures, which are then coupled to form system models. These sample models are used to obtain the CDF of the response variable by either applying Monte Carlo simulation or by generating data points for use in the response surface reliability method, which can perform the probabilistic analysis with an order of magnitude less computational effort. Both free- and forced-response analyses have been performed, and the results indicate that, while there is considerable room for improvement, the method produces usable and more representative solutions for the design of realistic structures with a substantial savings in computer time.

Brown, A. M.↗

NASA NTRS2001

Aeroservoelastic Uncertainty Model Identification from Flight Data

Uncertainty modeling is a critical element in the estimation of robust stability margins for stability boundary prediction and robust flight control system development. There has been a serious deficiency to date in aeroservoelastic data analysis with attention to uncertainty modeling. Uncertainty can be estimated from flight data using both parametric and nonparametric identification techniques. The model validation problem addressed in this paper is to identify aeroservoelastic models with associated uncertainty structures from a limited amount of controlled excitation inputs over an extensive flight envelope. The challenge to this problem is to update analytical models from flight data estimates while also deriving non-conservative uncertainty descriptions consistent with the flight data. Multisine control surface command inputs and control system feedbacks are used as signals in a wavelet-based modal parameter estimation procedure for model updates. Transfer function estimates are incorporated in a robust minimax estimation scheme to get input-output parameters and error bounds consistent with the data and model structure. Uncertainty estimates derived from the data in this manner provide an appropriate and relevant representation for model development and robust stability analysis. This model-plus-uncertainty identification procedure is applied to aeroservoelastic flight data from the NASA Dryden Flight Research Center F-18 Systems Research Aircraft.

Brenner, Martin J.↗

DOE OSTI2014

The Modern Role of Radiation Therapy in Treating Advanced-Stage Retinoblastoma: Long-Term Outcomes and Racial Differences

Purpose/Objective(s): To evaluate the effects of various patient characteristics and radiation therapy treatment variables on outcomes in advanced-stage retinoblastoma. Methods and Materials: This was a retrospective review of 41 eyes of 30 patients treated with external beam radiation therapy between June 1, 1992, and March 31, 2012, with a median follow-up time of 133 months (11 years). Outcome measures included overall survival, progression-free survival, local control, eye preservation rate, and toxicity. Results: Over 90% of the eyes were stage V. Definitive external beam radiation therapy (EBRT) was delivered in 43.9% of eyes, adjuvant EBRT in 22% of eyes, and second-line/salvage EBRT in 34.1% of eyes. A relative lens sparing (RLS) technique was used in 68.3% of eyes and modified lens sparing (MLS) in 24.4% of eyes. Three eyes were treated with other techniques. Doses ≥45 Gy were used in 68.3% of eyes. Chemotherapy was a component of treatment in 53.7% of eyes. The 10-year overall survival was 87.7%, progression-free survival was 80.5%, and local control was 87.8%. White patients had significantly better overall survival than did African-American patients in univariate analysis (hazard ratio 0.09; 95% confidence interval 0.01-0.84; P=.035). Toxicity was seen in 68.3% of eyes, including 24.3% with isolated acute dermatitis. Conclusions: External beam radiation therapy continues to be an effective treatment modality for advanced retinoblastoma, achieving excellent long-term local control and survival with low rates of treatment-related toxicity and secondary malignancy.

62 RADIOLOGY AND NUCLEAR MEDICINE↗

DOE OSTI2015

Value of Surveillance Studies for Patients With Stage I to II Diffuse Large B-Cell Lymphoma in the Rituximab Era

Background: The role of surveillance studies in limited-stage diffuse large B-cell lymphoma (DLBCL) in the rituximab era has not been well defined. We sought to evaluate the use of imaging (computed tomography [CT] and positron emission tomography [PET]-CT) scans and lactate dehydrogenase (LDH) in surveillance of patients with stage I to II DLBCL. Methods: A retrospective analysis was performed of patients who received definitive treatment between 2000 and 2013. Results: One hundred sixty-two consecutive patients with stage I to II DLBCL were treated with chemotherapy +/− rituximab, radiation, or combined modality therapy. The 5-year rates of overall survival (OS) and freedom from progression (FFP) were 81.2% and 80.8%, respectively. Of the 162 patients, 124 (77%) were followed up with at least 1 surveillance PET scan beyond end-of-treatment scans; of those, 94 of 124 (76%) achieved a complete metabolic response on PET scan after completion of chemotherapy, and this was associated with superior FFP (P=.01, HR=0.3) and OS (P=.01, HR 0.3). Eighteen patients experienced relapse after initial response to therapy. Nine relapses were initially suspected by surveillance imaging studies (8 PET, 1 CT), and 9 were suspected clinically (5 by patient-reported symptoms and 4 by symptoms and physical examination). No relapses were detected by surveillance LDH. The median duration from initiation of treatment to relapse was 14.3 months among patients with relapses suspected by imaging, and 59.8 months among patients with relapses suspected clinically (P=.077). There was no significant difference in OS from date of first therapy or OS after relapse between patients whose relapse was suspected by imaging versus clinically. Thirteen of 18 patients underwent successful salvage therapy after relapse. Conclusions: A complete response on PET scan immediately after initial chemotherapy is associated with superior FFP and OS in stage I to II DLBCL. The use of PET scans as posttreatment surveillance is not associated with a survival advantage. LDH is not a sensitive marker for relapse. Our results argue for limiting the use of posttreatment surveillance in patients with limited-stage DLBCL.

62 RADIOLOGY AND NUCLEAR MEDICINE↗

DOE OSTI2026

Cascading economic losses from port disruptions under capacity constrained multimodal freight networks

This study quantifies how throughput disruptions at major seaports cascade through capacity-constrained multimodal freight networks and interregional production systems. We couple an agent-based model (ABM) multimodal freight simulation that resolves rerouting, terminal queueing, and inventory drawdown under binding modal and facility capacities with a multiregional output loss input-output (MRIIM) model that propagates realized delivery shortfalls across regions and sectors. The framework is demonstrated for the Port of Los Angeles using Freight Analysis Framework flows and Bureau of Economic Analysis input-output accounts and is evaluated over a 52-week horizon under deterministic sector targeted shocks and stochastic disruption realizations with uncertain severity and duration. Results indicate nonlinear amplification: realized national losses concentrate in manufacturing and transportation/warehousing even when exogenous port shocks are dispersed, suggesting that congestion spillback and limited short-run substitution can dominate the initial shock allocation. We further evaluate a tabular reinforcement-learning (Q-learning) intervention layer that selects among a small set of implementable system level levers (truck-to-rail and truck-to-barge shift settings) without overriding shipper routing, finding that such interventions reduce total losses for moderate disruptions but yield diminishing returns once substitute modes approach capacity. By linking operational freight behavior to system wide impacts under uncertainty, the proposed ABM-MRIIM pipeline provides a reusable workflow for port disruption stress testing, identification of structurally critical sectors/corridors, and evaluation of resilience interventions under realistic capacity limits.

42 ENGINEERING↗

DOE OSTI2023

Chemical characterization of microplastic particles formed in airborne waste discharged from sewer pipe repairs

Microplastic particles are of increasing environmental concern due to the widespread uncontrolled degradation of various commercial products made of plastic and their associated waste disposal. Recently, common technology used to repair sewer pipes was reported as one of the emission sources of airborne microplastics in urban areas. This research presents results of the multi-modal comprehensive chemical characterization of the microplastic particles related to waste discharged in the pipe repair process and compares particle composition with the components of uncured resin and cured plastic composite used in the process. Analysis of these materials employs complementary use of surface-enhanced Raman spectroscopy, scanning transmission X-ray spectro-microscopy, single particle mass spectrometry, and direct analysis in real-time high-resolution mass spectrometry. Further, it is shown that the composition of the relatively large (100 μm) microplastic particles resembles components of plastic material used in the process. In contrast, the composition of the smaller (micrometer and sub-micrometer) particles is significantly different, suggesting their formation from unintended polymerization of water-soluble components occurring in drying droplets of the air-discharged waste. In addition, resin material type influences the composition of released microplastic particles. Results are further discussed to guide the detection and advanced characterization of airborne microplastics in future field and laboratory studies pertaining to sewer pipe repair technology.

54 ENVIRONMENTAL SCIENCES↗

NASA NTRS1993

Contact-impact analysis of deployable space systems

This paper presents simulation results of a flexible, deployable space system with multiple contact-impact events, using three different modeling approaches. In the first two approaches, the equations of motion of the system are written in terms of generalized coordinates of each component, with modal coordinates used to account for flexibility in the components. Two different methods are used to model contact-impact events in the systems. In the momentum balance method, as contact-impact occurs, momentum equations of the systems are solved for the jump discontinuity in velocity of generalized coordinates. Integration of the system is restarted with the new initial conditions from solutions of momentum equations. In the logical function method, a virtual spring connecting the two contact points is assumed. The virtual spring is active only when impact occurs. No special treatment is needed in the integration algorithm using this method. In the third approach, instead of using modal coordinates, a finite element based formulation for the transient dynamics of mechanical system is used to model flexibility of the components. The logical function method is used to model contact-impact in the third approach.

Wu, Shih-Chin↗

NASA NTRS1999

Acoustic Scattering by Three-Dimensional Stators and Rotors Using the SOURCE3D Code: Analysis and Results - Volume 1

This report provides a study of rotor and stator scattering using the SOURCE3D Rotor Wake/Stator Interaction Code. SOURCE3D is a quasi-three-dimensional computer program that uses three-dimensional acoustics and two-dimensional cascade load response theory to calculate rotor and stator modal reflection and transmission (scattering) coefficients. SOURCE3D is at the core of the TFaNS (Theoretical Fan Noise Design/Prediction System), developed for NASA, which provides complete fully coupled (inlet, rotor, stator, exit) noise solutions for turbofan engines. The reason for studying scattering is that we must first understand the behavior of the individual scattering coefficients provided by SOURCE3D, before eventually understanding the more complicated predictions from TFaNS. To study scattering, we have derived a large number of scattering curves for vane and blade rows. The curves are plots of output wave power divided by input wave power (in dB units) versus vane/blade ratio. Some of these plots are shown in this report. All of the plots are provided in a separate volume. To assist in understanding the plots, formulas have been derived for special vane/blade ratios for which wavefronts are either parallel or normal to rotor or stator chords. From the plots, we have found that, for the most part, there was strong transmission and weak reflection over most of the vane/blade ratio range for the stator. For the rotor, there was little transmission loss.

Meyer, Harold D.↗

NASA NTRS2001

Cross-Axis Proportional Gains Used to Control Gyroscopic Effects in a Magnetic- Bearing-Supported Flywheel

For magnetic-bearing-supported high-speed machines with significant gyroscopic effects, it is necessary to stabilize both forward and backward tilt whirling modes. Instability or the low damping of these modes can prevent the attainment of desired shaft speeds. Previous work elsewhere showed that cross-axis derivative gain in the magnetic bearing control law can improve the stability of the forward whirl mode, but it is commonly recognized that derivative gains amplify high-frequency noise and increase the required control effort. At the NASA Glenn Research Center, it has been shown previously that a simple cross-axis proportional gain can add stability (without adding noise) to either forward whirl or backward whirl, depending on the sign of the gain, but that such a gain destabilizes the other mode. It has been predicted by Glenn analysis that both modes can be stabilized by cross-axis proportional gains by utilizing the large-frequency separation of the two modes at speeds where the gyroscopic effects are significant. We use a modal controller that decouples the tilt and center-of-mass-translation modes. Only the tilt modes exhibit speed-dependent gyroscopic effects. The key to controlling them by the present method is to stabilize the backward whirl tilt mode with the appropriate sign of cross-axis proportional gain in the control law, but to include a low-pass filter on that gain term to restrict its effect only to the low-frequency backward-whirl mode. A second cross-axis term with the opposite sign and a high-pass filter stabilizes the forward whirl, which can have a frequency one or two orders of magnitude higher than the backward whirl, permitting very independent action of the two terms. Because the physical gyroscopic torques are proportional to the spinning speed of the shaft, it is convenient to gain-schedule the cross-axis control terms by making them proportional to shaft speed. This has the added benefit of avoiding a somewhat awkward zero-speed splitting of the tilt-mode eigenvalues.

Brown, Gerald V.↗

NASA NTRS2012

Follow on Researches for X-56A Aircraft at NASA Dryden Flight Research Center (Progress Report)

A lot of composite materials are used for the modern aircraft to reduce its weight. Aircraft aeroservoelastic models are typically characterized by significant levels of model parameter uncertainty due to composite manufacturing process. Small modeling errors in the finite element model will eventually induce errors in the structural flexibility and mass, thus propagating into unpredictable errors in the unsteady aerodynamics and the control law design. One of the primary objectives of X-56A aircraft is the flight demonstration of active flutter suppression, and therefore in this study, the identification of the primary and secondary modes is based on the flutter analysis of X-56A aircraft. It should be noted that for all three Mach number cases rigid body modes and mode numbers seven and nine are participated 89.1 92.4 % of the first flutter mode. Modal participation of the rigid body mode and mode numbers seven and nine for the second flutter mode are 94.6 96.4%. Rigid body mode and the first two anti-symmetric modes, eighth and tenth modes, are participated 93.2 94.6% of the third flutter mode. Therefore, rigid body modes and the first four flexible modes of X-56A aircraft are the primary modes during the model tuning procedure. The ground vibration test-validated structural dynamic finite element model of the X-56A aircraft is to obtain in this study. The structural dynamics finite element model of X-56A aircraft is improved using the parallelized big-bang big-crunch algorithm together with a hybrid optimization technique.

Structural Dynamic Model Tuning↗

DOE OSTI2016

Hemorrhagic Complications of Percutaneous Cryoablation for Renal Tumors: Results from a 7-year Prospective Study

PurposeCryoablation of renal tumors is assumed to have a higher risk of hemorrhagic complications compared to other ablative modalities. Our purpose was to establish the exact risk and to identify hemorrhagic risk factors.Materials and MethodsThis IRB approved, 7-year prospective study included 261 renal cryoablations. Procedures were under conscious sedation and CT guidance. Pre- and postablation CT was obtained, and hemorrhagic complications were CTCAE tabulated. Age, gender, tumor size, histology, and probes number were tested based on averages or proportions using their exact permutation distribution. “High-risk” subgroups (those exceeding the thresholds of all variables) were tested for each variable alone, and for all combinations of variable threshold values. We compared the subgroup with the best PPV using one variable, with the subgroup with the best PPV using all variables (McNemmar test).ResultsThe hemorrhagic complication rate was 3.5 %. Four patients required transfusions, two required emergent angiograms, one required both a transfusion and angiogram, and two required bladder irrigation for outlet obstruction. Perirenal space hemorrhage was more clinically significant than elsewhere. Univariate risks were tumor size >2 cm, number of probes >2, and malignant histology (P = 0.005, 0.002, and 0.033, respectively). Multivariate analysis showed that patients >55 years with malignant tumors >2 cm requiring 2 or more probes yielded the highest PPV (7.5 %).ConclusionsAlthough older patients (>55 years old) with larger (>2 cm), malignant tumors have an increased risk of hemorrhagic complications, the low PPV does not support the routine use of embolization. Percutaneous cryoablation has a 3.5 % risk of significant hemorrhage, similar to that reported for other types of renal ablative modalities.

62 RADIOLOGY AND NUCLEAR MEDICINE↗

DOE OSTI2014

Role of Genetic Polymorphisms in NFKB-Mediated Inflammatory Pathways in Response to Primary Chemoradiation Therapy for Rectal Cancer

Purpose: To investigate whether polymorphisms of genes related to inflammation are associated with pathologic response (primary endpoint) in patients with rectal cancer treated with primary chemoradiation therapy (PCRT). Methods and Materials: Genomic DNA of 159 patients with locally advanced rectal cancer treated with PCRT was genotyped for polymorphisms rs28362491 (NFKB1), rs1213266/rs5789 (PTGS1), rs5275 (PTGS2), and rs16944/rs1143627 (IL1B) using TaqMan single nucleotide polymorphism genotyping assays. The association between each genotype and pathologic response (poor response vs complete or partial response) was analyzed using logistic regression models. Results: The NFKB1 DEL/DEL genotype was associated with pathologic response (odds ratio [OR], 6.39; 95% confidence interval [CI], 0.78-52.65; P=.03) after PCRT. No statistically significant associations between other polymorphisms and response to PCRT were observed. Patients with the NFKB1 DEL/DEL genotype showed a trend for longer disease-free survival (log-rank test, P=.096) and overall survival (P=.049), which was not significant in a multivariate analysis that included pathologic response. Analysis for 6 polymorphisms showed that patients carrying the haplotype rs28362491-DEL/rs1143627-A/rs1213266-G/rs5789-C/rs5275-A/rs16944-G (13.7% of cases) had a higher response rate to PCRT (OR, 8.86; 95% CI, 1.21-64.98; P=.034) than the reference group (rs28362491-INS/rs1143627-A/rs1213266-G/rs5789-C/rs5275-A/rs16944-G). Clinically significant (grade ≥2) acute organ toxicity was also more frequent in patients with that same haplotype (OR, 4.12; 95% CI, 1.11-15.36; P=.037). Conclusions: Our results suggest that genetic variation in NFKB-related inflammatory pathways might influence sensitivity to primary chemoradiation for rectal cancer. If confirmed, an inflammation-related radiogenetic profile might be used to select patients with rectal cancer for preoperative combined-modality treatment.

62 RADIOLOGY AND NUCLEAR MEDICINE↗

DOE OSTI2011

Reply to ''Comment on 'Modal expansion approach to optical-frequency-comb generation with monolithic whispering-gallery-mode resonators'''

In a Comment [Deych, Phys. Rev. A 84, 017801 (2011)] on our recent article [Chembo and Yu, Phys. Rev. A 82, 033801 (2010)] on Kerr comb generation in monolithic whispering-gallery-mode (WGM) resonators, the author claims that even though our main results ''remain intact'', the framework of our analysis contains some mathematical errors. In this Reply, we demonstrate that the author's criticisms and his alternative theory are incorrect, and that all the disagreeing claims come from the author's misunderstanding of the physical system under investigation. In particular, the main conceptual error in the Comment is the confusion between evanescent and radiative coupling mechanisms for WGM resonators (in terms of Q factor, this is in our case a confusion between {approx}10{sup 9} and {approx}10{sup 2000}, respectively). This essential misconception leads for example the author to introduce a nonphysical {approx}10{sup 2000} multiplicative correction factor for the laser pump power. We show in this Reply that our WGM resonators are radiatively closed (because of the quasi-infinite radiative Q factor), so that the Mie scattering formalism proposed by Deych, which relies on radiative coupling, can only lead to erroneous results. We also show that the modal expansion approach in our original paper is appropriate, and all our approximations are physically well justified. We therefore stand by our modeling results, which are moreover in excellent agreement with the experiments reported in [Chembo, Strekalov, and Yu, Phys. Rev. Lett. 104, 103902 (2010)].

71 CLASSICAL AND QUANTUM MECHANICS, GENERAL PHYSIC↗

NASA NTRS1980

NASTRAN level 16 user's manual updates for aeroelastic analysis of bladed discs

The NASTRAN aeroelastic and flutter capability was extended to solve a class of problems associated with axial flow turbomachines. The capabilities of the program are briefly discussed. The aerodynamic data pertaining to the bladed disc sector, the associated aerodynamic modeling, the steady aerothermoelastic 'design/analysis' formulations, and the modal, flutter, and subcritical roots analyses are described. Sample problems and their solutions are included.

Elchuri, V.↗

NASA NTRS2016

Expanding the Natural Laminar Flow Boundary for Supersonic Transports

A computational design and analysis methodology is being developed to design a vehicle that can support significant regions of natural laminar flow (NLF) at supersonic flight conditions. The methodology is built in the CDISC design module to be used in this paper with the flow solvers Cart3D and USM3D, and the transition prediction modules BLSTA3D and LASTRAC. The NLF design technique prescribes a target pressure distribution for an existing geometry based on relationships between modal instability wave growth and pressure gradients. The modal instability wave growths (both on- and off-axes crossflow and Tollmien-Schlichting) are balanced to produce a pressure distribution that will have a theoretical maximum NLF region for a given streamwise wing station. An example application is presented showing the methodology on a generic supersonic transport wingbody configuration. The configuration has been successfully redesigned to support significant regions of NLF (approximately 40% of the wing upper surface by surface area). Computational analysis predicts NLF with transition Reynolds numbers (ReT) as high as 36 million with 72 degrees of leading-edge sweep (ΛLE), significantly expanding the current boundary of ReT - ΛLE combinations for NLF. This NLF geometry provides a total drag savings of 4.3 counts compared to the baseline wing-body configuration (approximately 5% of total drag). Off-design evaluations at near-cruise and low-speed, high-lift conditions are discussed, as well as attachment line contamination/transition concerns. This computational NLF design effort is a part of an ongoing cooperative agreement between NASA and JAXA researchers.

Lynde, Michelle N.↗

DOE OSTI2016

Big Data Analytics for Scanning Transmission Electron Microscopy Ptychography

Electron microscopy is undergoing a transition; from the model of producing only a few micrographs, through the current state where many images and spectra can be digitally recorded, to a new mode where very large volumes of data (movies, ptychographic and multi-dimensional series) can be rapidly obtained. In this paper, we discuss the application of so-called “big-data” methods to high dimensional microscopy data, using unsupervised multivariate statistical techniques, in order to explore salient image features in a specific example of BiFeO 3 domains. Remarkably, k-means clustering reveals domain differentiation despite the fact that the algorithm is purely statistical in nature and does not require any prior information regarding the material, any coexisting phases, or any differentiating structures. While this is a somewhat trivial case, this example signifies the extraction of useful physical and structural information without any prior bias regarding the sample or the instrumental modality. Further interpretation of these types of results may still require human intervention. Finally, however, the open nature of this algorithm and its wide availability, enable broad collaborations and exploratory work necessary to enable efficient data analysis in electron microscopy.

36 MATERIALS SCIENCE↗