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At least 1,441 records · Page 80
All sourcesNASA NTRSDOE OSTI
NASA NTRS2000

Analysis of MIR-18 results for physical and biological dosimetry: radiation shielding effectiveness in LEO

We compare models of radiation transport and biological response to physical and biological dosimetry results from astronauts on the Mir space station. Transport models are shown to be in good agreement with physical measurements and indicate that the ratio of equivalent dose from the Galactic Cosmic Rays (GCR) to protons is about 3/2:1 and that this ratio will increase for exposures to internal organs. Two biological response models are used to compare to the Mir biodosimetry for chromosome aberration in lymphocyte cells; a track-structure model and the linear-quadratic model with linear energy transfer (LET) dependent weighting coefficients. These models are fit to in vitro data for aberration formation in human lymphocytes by photons and charged particles. Both models are found to be in reasonable agreement with data for aberrations in lymphocytes of Mir crew members: however there are differences between the use of LET dependent weighting factors and track structure models for assigning radiation quality factors. The major difference in the models is the increased effectiveness predicted by the track model for low charge and energy ions with LET near 10 keV/micrometers. The results of our calculations indicate that aluminum shielding, although providing important mitigation of the effects of trapped radiation, provides no protective effect from the galactic cosmic rays (GCR) in low-earth orbit (LEO) using either equivalent dose or the number of chromosome aberrations as a measure until about 100 g/cm 2 of material is used.

Flight Experiment↗
NASA NTRS1988

Probabilistic system identification in the time domain

The objective of system identification is to determine reliable dynamical models of a structure by systematically using its measured excitation and response. It brings together in an integrated fashion, experimental, analytical, and computational techniques in structural dynamics. Areas of application for system identification include the following: (1) Model Evaluation--assessing assumptions (linearity and equivalent viscous damping) and techniques (finite-element modeling) used to construct theoretical models of a structure; (2) Model Improvement--updating of a theoretical model to enable more accurate response predictions for possible future loads on the structure, or for control of the structure; (3) Empirical Modelling--developing empirical relationships (nonlinear models) or empirical parameter values (modal damping) because the present state of the art does not provide theoretical results; and (4) Damage Detection and Assessment--continual or episodic updating of a structural model through vibration monitoring to detect and locate any structural damage. It can be argued that since the construction or modification of models using test data is subject to inherent uncertainties, the above problems should be properly treated within a Bayesian probabilistic framework. Such a methodology is presented which allows the precision of the estimates of the model parameters to be computed. It also leads to a guiding principle in applications. Namely, when selecting a single model from a given class of models, one should take the most probable model in the class based on the experimental data. Practical applications of this principle are given which are based on the utilization of measured seismic motions in large civil structures. Examples include the application of a computer program MODE-ID to identify modal properties directly from seismic excitation and response time histories from a nine-story steel-frame building at JPL and from a freeway overpass bridge.

Beck, James L.↗
NASA NTRS2018

Variability in Galactic Cosmic Radiation- Induced DNA Damage Response in Inbred Mice Is Modulated by Genetics

In radiation biology, the ability to predict cancer risk associated with exposure to low doses of high-LET (Linear Energy Transfer) ionizing radiation remains a challenge. Epidemiological methods lack the sensitivity and power to provide detailed risk estimates for cancer and ignore individual sensitivity. We have hypothesized that DNA repair capacity is the primary factor differentiating peoples radiation sensitivity. We previously showed in immortalized human cell lines that characterizing the dose and time dependence of p53-binding protein 1 (53BP1) foci formation in the nucleus following X-rays exposure is sufficient to predict DNA repair response to any other LET in the same cell line. We now tested this hypothesis across a population of mice with different genetic background. Fibroblast cells were extracted and cultivated from 76 individual mice from 15 different strains and exposed to HZE (high (H) atomic number (Z) and energy (E) galactic cosmic ray particles) particles and X-rays. Individual radiation sensitivities were investigated by high throughput measurement of DNA repair kinetics that evaluated 53bp1 foci numbers as a surrogate for DNA double-strand breaks at various times post-irradiation. Instead of just counting foci which can be hard to distinguish for high-LET or high doses, we also took into account the track structure of high-LET particles to compute the remaining number of unrepaired tracks as a function of time post-irradiation. As expected, the percentage of unrepaired track over a 48 hours follow-up period increased with LET. In addition, repair rate was modulated by genetics, with animals from the same strain showing small variance while large rate differences were observed between strains. Radiation strain sensitivity ranking was estimated based on repair rates from exposure to each LET evaluated in this work, and ranking for high-LET correlated better with ranking from high dose of X-ray, not low dose. At the in-vivo level, drops in T-cells and B-cells number measured 24 hours after 0.1 Gy (Gray) X-ray exposure, correlated with slower DNA repair kinetic in fibroblast cells of the same strains of mice. At the genomic level, mouse genome wide association (GWA) analysis identified seven significant genetic loci on chromosomes 2, 3, 7, 10, 11, 13 and 19 with different significance depending on the LET. Interestingly, for the two highest LET, a common locus on Chromosome 10 was identified with high enrichment for DNA repair associated genes.Overall, this work suggests that repair kinetics of primary skin fibroblasts is a good surrogate marker for in-vivo radiation sensitivities in other tissues and that this response is modulated by genetics. Our study also confirms that DNA repair kinetics following high doses of X-ray can be used to predict radiation sensitivity to high-LET.

High-LET Radiation↗
NASA NTRSDate not supplied

Effects of Mild Hypobaric Hypoxia on Response From Mild Exercise in NASA Exploration Atmosphere Tests

INTRODUCTION: The NASA Exploration Atmosphere study aims to validate a new prebreathe protocol incorporating an alternate habitat atmosphere of 56.5 kPa (8.2psia), 34% O 2 , and 66% N 2 to control and mitigate decompression sickness risk associated with spaceflight extravehicular activities. This alternate atmosphere results in a mild hypoxic environment (PIO 2 of 128 mmHg) that may influence inhabitant physiological responses to exercise. Therefore, the responses to light exercise in relation to the mild hypobaric hypoxic environment were investigated. METHODS: Eight participants (4M/4F; age=38.3±9.0 yr; weight=76.0±13.1 kg; peak aerobic capacity [VO 2 pk]= 3.1±0.7 L/min) were exposed to a mild hypobaric hypoxic environment for 11 days in NASA’s 20-foot hypobaric chamber at Johnson Space Center. Participants alternated test days between a habitat atmosphere of 56.5 kPA/34% O 2 and simulated 6-hour EVA environment, 29.6 kPa/85% O 2 . Participants completed pre-mission graded VO 2 pk tests on a LODE cycle ergometer with ParvoMedics metabolic analyzer. Submaximal aerobic tests were performed pre and during the mission (10-minutes of exercise at a workload of 40% VO 2 pk).Pre-mission, performed submaximal exercise exposed to a breathing air mixture of, 18% O 2 and balance N 2 , to simulate the mildly hypoxic environment within the 20-foot chamber. Linear mixed models (fixed effect: test day; random effects: subject, age) were performed to determine whether physiological responses (oxygen uptake [VO 2 ], carbon dioxide production [VCO 2 ], ventilation [VE], oxygen saturation [SPO 2 ], heart rate [HR], respiratory exchange ratio [RER]) to submaximal exercise performed within the 20-foot hypobaric chamber every 2 days differed from the pre-mission (18% O 2 ) testing. Results are presented as estimated marginal means with lower and upper confidence limits, with significance set to 0.05. RESULTS AND DISCUSSION: Seven of eight participants completed the chamber study. Mixed models for VO 2 , VCO 2 , SpO 2 , HR, and RER indicated negligible impact of the mild hypoxic chamber environment compared to pre-mission testing (all p>0.05).Results for VE indicated a minor impact of chamber environment compared to pre-mission testing (37.0 L/min [30.8, 43.2]), with increased VE at test day 10 (40.4 L/min [34.2, 46.6]; p= 0.029).The aerobic performance data collected suggests limited physiologic responses to mild exercise when performed at normobaric hypoxia and hypobaric hypoxia.

B Siders↗
NASA NTRS1982

Dynamic response of lined tunnels by boundary elements

The dynamic stress concentration manifested around a lined cylindrical tunnel buried in an infinitely extending linear elastic or viscoelastic medium due to the passage of transient disturbances was investigated. Plane strain is assumed to hold and the transient disturbances can be of any arbitrary time variation. The boundary element method formulated in the Laplace transform domain is employed. Isoparametric boundary elements are used in the discretization of the liner and tunnel surfaces. Viscoelastic material behavior can be readily obtained from the linear elastic case in the Laplace transform domain through the use of the correspondence principle. The transient solution is recovered by numerical inversion of the solution obtained in the transformed domain.

Manolis, G. D.↗
NASA NTRS1986

Response of symmetric rectangular composite laminates with nonlinear damping subjected to acoustic loading

Effects of both nonlinear damping and large-deflection are included in the analysis in an attempt to explain the experimental phenomena of aircraft panels excited at high sound pressure levels; that is the broadening and flattening out of the strain response peaks and the increasing of the response frequency. A nonlinear damping model is considered in the analysis using a single-mode approach. Root-mean-square (RMS) maximum deflection, RMS strains, spectral density functions of strain, and equivalent linear frequency are obtained for clamped and simply supported rectangular symmetric laminated composite plates. It is demonstrated that nonlinear damping is the one which causes the broadening of the response peaks, and it has great influence on RMS panel deflection, RMS strains, and frequency.

Mei, C.↗
NASA NTRS1996

The Use of Structural-Acoustic Techniques to Assess Potential Structural Damage From Sonic Booms

The potential impact of supersonic operations includes structural damage from the sonic boom overpressure. This paper describes a study of how structural-acoustic modeling and testing techniques may be used to assess the potential for such damage in the absence of actual flyovers. Procedures are described whereby transfer functions relating structural response to sonic boom signature may be obtained with a stationary acoustic source and appropriate data processing. Further, by invoking structural-acoustic reciprocity, these transfer functions may also be acquired by measuring the radiated sound from the structure under a mechanical drive. The approach is based on the fundamental assumption of linearity, both with regard to the (acoustic) propagation of the boom in the vicinity of the structure and to the structure's response. Practical issues revolve around acoustic far field and source directivity requirements. The technique was implemented on a specially fabricated test structure at Edwards AFB, CA with the support of Wyle Laboratories, Inc. Blank shots from a cannon served as our acoustic source and taps from an instrumented hammer generated the mechanical drive. Simulated response functions were constructed. Results of comparisons with corresponding measurements recorded during dedicated supersonic flyovers with F-15 aircraft are presented for a number of sensor placements.

Garrelick, Joel↗
NASA NTRS1985

Application of two-dimensional unsteady aerodynamic to a free-tip rotor response analysis

The free-tip rotor utilizes a rotor blade tip which is structurally decoupled from the blade inboard section. The tip is free to pitch about its own pitch axis to respond to the local flow angularity changes. The tip also experiences the heaving motion due to the flapping of the rotor blade. For an airfoil in any pitching and heaving motion which can be expanded into a Fourier series, the lift and moment calculated by Theodoren's theory is simply the linear combination of the lift and moment calculated for each harmonic. These lift and moment are then used to determine the response of the free-tip rotor. A parametric study is performed to determine the effect of mechanical damping, mechanical spring, sweep, friction, and a constant control moment on the free-tip rotor response characteristics and the resulting azimuthal lift distributions. The results showed that the free-tip has the capability to suppress the oscillatory lift distribution around the azimuth and to eliminate a significant negative life peak on the advancing tip. This result agrees with the result of the previous analysis based on the steady aerodynamics.

Yates, L.↗
NASA NTRS1993

Dynamic of Langmuir and Ion-Sound Waves in Type 3 Solar Radio Sources

The evolution of Langmuir and ion-sound waves in type 3 sources is investigated, incorporating linear growth, linear damping, and nonlinear electrostatic decay. Improved estimates are obtained for the wavenumber range of growing waves and the nonlinear coupling coefficient for the decay process. The resulting prediction for the electrostatic decay threshold is consistent with the observed high-field cutoff in the Langmuir field distribution. It is shown that the conditions in the solar wind do not allow a steady state to be attained; rather, bursty linear and nonlinear interactions take place, consistent with the highly inhomogeneous and impulsive waves actually observed. Nonlinear growth is found to be fast enough to saturate the growth of the parent Langmuir waves in the available interaction time. The resulting levels of product Langmuir and ion-sound waves are estimated theoretically and shown to be consistent with in situ ISEE 3 observations of type 3 events at 1 AU. Nonlinear interactions slave the growth and decay of product sound waves to that of the product Langmuir waves. The resulting probability distribution of ion-sound field strengths is predicted to have a flat tail extending to a high-field cutoff. This prediction is consistent with statistics derived here from ISEE 3 observations. Agreement is also found between the frequencies of the observed waves and predictions for the product S waves. The competing processes of nonlinear wave collapse and quasilinear relaxation are discussed, and it is concluded that neither is responsible for the saturation of Langmuir growth. When wave and beam inhomogeneities are accounted for, arguments from quasi-linear relaxation yield an upper bound on the Langmuir fields that is too high to be relevant. Nor are the criteria for direct wave collapse of the beam-driven waves met, consistent with earlier simulation results that imply that this process is not responsible for saturation of the beam instability. Indeed, even if the highest observed Langmuir fields are assumed to he part of a long-wavelength 'condensate' produced via electrostatic decay, they still fall short of the relevant requirements for wave collapse. The most stringent requirement for collapse is that collapsing wave packets not be disrupted by ambient density fluctuations in the solar wind. Fields of several mV m(exp -1) extending over several hundred km would be needed to satisfy this requirement; at 1 AU such fields are rare at best.

Robinson, P. A.↗
NASA NTRS1977

Manual control of yaw motion with combined visual and vestibular cues

Measurements are made of manual control performance in the closed-loop task of nulling perceived self-rotation velocity about an earth-vertical axis. Self-velocity estimation was modelled as a function of the simultaneous presentation of vestibular and peripheral visual field motion cues. Based on measured low-frequency operator behavior in three visual field environments, a parallel channel linear model is proposed which has separate visual and vestibular pathways summing in a complementary manner. A correction to the frequency responses is provided by a separate measurement of manual control performance in an analogous visual pursuit nulling task. The resulting dual-input describing function for motion perception dependence on combined cue presentation supports the complementary model, in which vestibular cues dominate sensation at frequencies above 0.05 Hz. The describing function model is extended by the proposal of a non-linear cue conflict model, in which cue weighting depends on the level of agreement between visual and vestibular cues.

Zacharias, G. L.↗
NASA NTRS1995

Triggering of longitudinal combustion instabilities in solid rocket motors: Nonlinear combustion response

Pulsed oscillations in solid rocket motors are investigated with emphasis on nonlinear combustion response. The study employs a wave equation governing the unsteady motions in a two-phase flow, and a solution technique based on spatial- and time-averaging. A wide class of combustion response functions is studied to second-order in fluctuation amplitude to determine if, when, and how triggered instabilities arise. Conditions for triggering are derived from analysis of limit cycles, and regions of triggering are found in parametric space. Based on the behavior of model dynamical systems, introduction of linear cross-coupling and quadratic self-coupling among the acoustic modes appears to be the manner in which the nonlinear combustion response produces triggering to a stable limit cycle. Regions of initial conditions corresponding to stable pulses were found, suggesting that stability depends on initial phase angle and harmonic content, as well as the composite amplitude, of the pulse.

Wicker, J. M.↗
NASA NTRS1989

Numerical simulations of impulsively heated solar flares

The response of a model solar atmosphere to heating by an electron beam has been studied for electron beam flux spectra which are power laws with low-energy 'knees' (rising linearly with time to a peak at 30 s and then falling linearly to 0 at 60 s) ranging from 10 to 20 keV. The results indicate that high peak electron beam fluxes, low-energy knees, and larger spectral indices all move the atmospheric response toward greater enhancements of the parameters in the coronal regions of the atmosphere. Coronal responses can thus be used as a diagnostic of the parameters of the electron beam.

Mariska, John T.↗
NASA NTRS1973

Nonlinear transient analysis of multi-mass flexible rotors - theory and applications

The equations of motion necessary to compute the transient response of multi-mass flexible rotors are formulated to include unbalance, rotor acceleration, and flexible damped nonlinear bearing stations. A method of calculating the unbalance response of flexible rotors from a modified Myklestad-Prohl technique is discussed in connection with the method of solution for the transient response. Several special cases of simplified rotor-bearing systems are presented and analyzed for steady-state response, stability, and transient behavior. These simplified rotor models produce extensive design information necessary to insure stable performance to elastic mounted rotor-bearing systems under varying levels and forms of excitation. The nonlinear journal bearing force expressions derived from the short bearing approximation are utilized in the study of the stability and transient response of the floating bush squeeze damper support system. Both rigid and flexible rotor models are studied, and results indicate that the stability of flexible rotors supported by journal bearings can be greatly improved by the use of squeeze damper supports. Results from linearized stability studies of flexible rotors indicate that a tuned support system can greatly improve the performance of the units from the standpoint of unbalanced response and impact loading. Extensive stability and design charts may be readily produced for given rotor specifications by the computer codes presented in this analysis.

Kirk, R. G.↗
NASA NTRS1991

How to observe the gyre to global-scale variability in satellite altimetry - Signal attenuation by orbit error removal

Formulas analogous to the frequency response functions for commonly used filters in orbit error removal are analytically derived to devise observational strategies for the large-scale oceanic variability and to decipher the signal contents of previous results. These include the polynomial orbit error approximations, i.e., the linear, bias-only and quadratic corrections, and the sinusoidal orbit error approximations (the purely sinusoidal correction, and the sinusoid-and-bias correction). It is shown that the frequency response function for a polynomial correction is a function of the ratio of wavelength/track length and to retain 90 percent or more of the signal at a certain wavelength, the ratio must be less than 0.65 (for the quadratic case), 0.90 (linear), and 1.54 (bias-only).

Tai, Chang-Kou↗
NASA NTRS2002

Total-body irradiation with high-LET particles: acute and chronic effects on the immune system

Although the immune system is highly susceptible to radiation-induced damage, consequences of high linear energy transfer (LET) radiation remain unclear. This study evaluated the effects of 0.1 gray (Gy), 0.5 Gy, and 2.0 Gy iron ion (56Fe(26)) radiation on lymphoid cells and organs of C57BL/6 mice on days 4 and 113 after whole body exposure; a group irradiated with 2.0 Gy silicon ions (28Si) was euthanized on day 113. On day 4 after 56Fe irradiation, dose-dependent decreases were noted in spleen and thymus masses and all major leukocyte populations in blood and spleen. The CD19(+) B lymphocytes were most radiosensitive and NK1.1(+) natural killer (NK) cells were most resistant. CD3(+) T cells were moderately radiosensitive and a greater loss of CD3(+)/CD8(+) T(C) cells than CD3(+)/CD4(+) T(H) cells was noted. Basal DNA synthesis was elevated on day 4, but response to mitogens and secretion of interleukin-2 and tumor necrosis factor-alpha were unaffected. Signs of anemia were noted. By day 113, high B cell numbers and low T(C) cell and monocyte percents were found in the 2.0 Gy 56Fe group; the 2.0 Gy 2)Si mice had low NK cells, decreased basal DNA synthesis, and a somewhat increased response to two mitogens. Collectively, the data show that lymphoid cells and tissues are markedly affected by high linear energy transfer (LET) radiation at relatively low doses, that some aberrations persist long after exposure, and that different consequences may be induced by various densely ionizing particles. Thus simultaneous exposure to multiple radiation sources could lead to a broader spectrum of immune dysfunction than currently anticipated.

NASA Discipline Radiation Health↗
NASA NTRSDate not supplied

Reduced-Order Aerodynamic Modeling Based on CFD Frequency Responses from Multisine Inputs

A system identification analysis was performed to determine a reduced-order model (ROM) of a computational fluid dynamics (CFD) solver in support of linear aeroservoelastic model development and feedback control design. The approach was applied to the FUN3D code for the half-span wind tunnel test article used in the NASA-Boeing collaboration called the Integrated Adaptive Wing Technology Maturation (IAWTM) project. In a transonic flow condition, multiple inputs (11 structural mode displacements and 3 control surface deflections) were simultaneously excited with orthogonal phase-optimized multisines while multiple outputs (the corresponding 14 generalized aerodynamic forces) were recorded. From these recorded times series, the matrix of frequency responses was computed and subsequently fit using rational function approximations (RFAs). It was found that the entire (14 x 14) matrix of frequency responses could be determined from a single CFD run and that results generally followed trends predicted using other methods. Differences were attributed to the modeling fidelity and nonlinearities from structural mode and control surface interactions at higher reduced frequencies. More accurate fits of the RFAs to the frequency response data were obtained by making two CFD runs, one with only structural mode excitations and one with only control surface excitations, which reduced the degree of nonlinearity in the modeling data.

Aeroservoelasticity↗
NASA NTRS1974

Identification of structural parameters from helicopter dynamic test data

A method is presented for obtaining the mass, stiffness, and damping parameters of a linear mathematical model, having fewer degrees of freedom than the structure it represents, directly from dynamic response measurements on the actual helicopter without a priori knowledge of the physical characteristics of the fuselage. The only input information required in the formulation is the approximate natural frequency of each mode and mobility data measured proximate to these frequencies with sinusoidal force excitation applied at only one point on the vehicle. The practicality and numerical soundness of the theoretical development was demonstrated through a computer simulation of an experimental program.

Giansante, N.↗
NASA NTRS1976

Irradiate-anneal screening of total dose effects in semiconductor devices

An extensive investigation of irradiate-anneal (IRAN) screening against total dose radiation effects was carried out as part of a program to harden the Mariner Jupiter/Saturn 1977 (MJS'77) spacecraft to survive the Jupiter radiation belts. The method consists of irradiating semiconductor devices with Cobalt-60 to a suitable total dose under representative bias conditions and of separating the parts in the undesired tail of the distribution from the bulk of the parts by means of a predetermined acceptance limit. The acceptable devices are then restored close to their preirradiation condition by annealing them at an elevated temperature. IRAN was used when lot screen methods were impracticable due to lack of time, and when members of a lot showed a diversity of radiation response. The feasibility of the technique was determined by testing of a number of types of linear bipolar integrated circuits, analog switches, n-channel JFETS and bipolar transistors. Based on the results of these experiments a number of device types were selected for IRAN of flight parts in the MJS'77 spacecraft systems. The part types, screening doses, acceptance criteria, number of parts tested and rejected as well as the program steps are detailed.

Stanley, A. G.↗