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At least 1,441 records · Page 80

All sources NASA NTRS DOE OSTI

NASA NTRS2001

Multiuser Droplet Combustion Apparatus Developed to Conduct Combustion Experiments

A major portion of the energy produced in the world today comes from the combustion or burning of liquid hydrocarbon fuels in the form of droplets. However, despite vigorous scientific examinations for over a century, researchers still lack a full understanding of many fundamental combustion processes of liquid fuels. Understanding how these fuel droplets ignite, spread, and extinguish themselves will help us develop more efficient ways of energy production and propulsion, as well as help us deal better with the problems of combustion-generated pollution and fire hazards associated with liquid combustibles. The ability to conduct more controlled experiments in space, without the complication of gravity, provides scientists with an opportunity to examine these complicated processes closely. The Multiuser Droplet Combustion Apparatus (MDCA) supports this continued research under microgravity conditions. The objectives are to improve understanding of fundamental droplet phenomena affected by gravity, to use research results to advance droplet combustion science and technology on Earth, and to address issues of fire hazards associated with liquid combustibles on Earth and in space. MDCA is a multiuser facility designed to accommodate different combustion science experiments. The modular approach permits the on-orbit replacement of droplet combustion principal investigator experiments such as different fuels, droplet-dispensing needles, and droplet-tethering mechanisms. Large components such as the avionics, diagnostics, and base-plate remain on the International Space Station to reduce the launch mass of new experiments. MDCA is also designed to operate in concert with ground systems on Earth to minimize the involvement of the crew during orbit.

Myhre, Craig A.↗

DOE OSTI2012

Transarterial Chemoembolization With Cisplatin as Second-Line Treatment for Hepatocellular Carcinoma Unresponsive to Chemoembolization With Epirubicin-Lipiodol Emulsion

Purpose: The purpose of this retrospective study was to investigate the efficacy of transarterial chemoembolization (TACE) using cisplatin as a second-line treatment for advanced hepatocellular carcinoma (HCC) unresponsive to TACE using epirubicin-Lipiodol emulsion at our institution. Materials and Methods: Between January 2006 and March 2009, 51 patients with unresectable HCC underwent TACE using cisplatin. All patients had shown persistent viable tumor or tumor progression after at least 2 sessions of TACE using epirubicin-Lipiodol emulsion. TACE procedures consisted of arterial injection of a mixture of Lipiodol and cisplatin (30-100 mg [mean 57 {+-} 21]) (n = 29) or arterial infusion of cisplatin (30-100 mg [mean 87 {+-} 19]) solution (n = 22) followed by injection of 1-mm porous gelatin particles. Early tumor response was assessed by contrast-enhanced computed tomography (CT) according to Response Evaluation Criteria in Solid Tumors (RECIST) and European Association for the Study of the Liver (EASL) criteria. Overall survival and progression-free survival was calculated using the Kaplan-Meier method. Toxicity was assessed according to NCI-CTCAE version 3 criteria. Results: Response rates were 11.8 and 27.5% by RECIST and EASL criteria, respectively. Overall survival rates were 61.9, 48.2, and 28.9% at 1, 2, and 3 years, respectively, and the median survival time was 15.4 months. Progression-free survival rate was 35.2% at 1 year, and median progression-free survival time was 3.1 months. No major complications were observed, and the occurrence of postembolization syndrome was minimal. Grade 3 to 4 toxicities included thrombocytopenia (5.8%), increased aspartate aminotransferase (AST) level (35.3%), and increased alanine aminotransferase (ALT) level (23.5%). Conclusions: witching the TACE anticancer drug from epirubicin to cisplatin might be the feasible option for advanced HCC, even when considered resistant to the initial form of TACE.

62 RADIOLOGY AND NUCLEAR MEDICINE↗

DOE OSTI2022

Optical spectroscopic tools for standoff uranium detection

Rapid and standoff analysis of uranium is important for many applications. We present the recent advances in standoff detection of uranium using emission and laser-induced fluorescence spectroscopy in conjunction with ultrafast laser filament ablation-based solid sampling.

(020.3260) Isotope shifts, (140.3440) Laser-induce↗

DOE OSTI2012

Investigations of the plasma and structure based accelerators

The objective of our research during the reported period was three-fold: (a) theoretical investigation of novel mechanisms of injection into laser wake field accelerators; (b) theoretical investigation of single-shot frequency domain diagnostics of relativistic plasma wakes, specifically in the context of spatio-temporal evolution of the plasma bubble;(c) experimental and theoretical investigation of laser-driven accelerating structure, specifically in the context of the Surface Wave Accelerator Based on SiC (SWABSIC).

43 PARTICLE ACCELERATORS↗

DOE OSTI2018

Summary of RF Technology Program Activities, October 2013 - September 2017

The goals of the National RF Research and Development Program (NRRDP) are to advance the basic understanding of high-power radio frequency (RF) in a plasma environment, and to maintain the high-power transmitters and cooling water systems required to support the ITER Ion Cylcotron Range of Frequencies (ICRF) transmission line high power component testing and operation of the Proto-Material Plasma Exposure eXperiment (MPEX) device. The work includes the study of the RF sheath, and development of RF-related diagnostics. These include active and passive spectroscopic diagnostics that can provide local and line integrated measurements of RF and Direct Current (DC) electric fields in the edge plasma of fusion devices, as well as measurements of other parameters. One of these, the Doppler Free Saturation Spectroscopy (DFSS) diagnostic, utilizes a laser beam split into two intersecting, counter-propagating pump and probe beams, whose intersection defines the measurement region. DFSS has demonstrated measurements of atomic spectra with 500 times greater resolution than passive Optical Emission Spectroscopy (OES). This allows Stark effect based electric field measurements to be made with two orders of magnitude high sensitivity than with OES. Measurements have been made using an ORNL electron-cyclotron resonant (ECR) plasma source producing densities up to 10 19 m -3 , in the vicinity of an RF-biased planar electrode.

47 OTHER INSTRUMENTATION↗

DOE OSTI2024

Testing and validating SMDS algorithms implemented in the cloud

Pacific Northwest National Laboratory (PNNL) provided technical assistance to NorthWrite Inc. under the Small Business Vouchers (SBV) Pilot. NorthWrite delivered services to owners of small commercial buildings, using a cloud-based service to monitor, control, and optimize building operations, saving energy and reducing operating costs for the owners while ensuring that occupant comfort needs were consistently met. NorthWrite had a longstanding desire to add a new suite of diagnostic capabilities to their service offering and had been trying, without success, to incorporate several diagnostic algorithms published by PNNL. These algorithms arise from research previously supported by BTO. Through the SBV awarded to NorthWrite, PNNL made available technical knowledge regarding the derivation and application of the following sets of algorithms for use in the NorthWrite Cloud-based service delivery system: • algorithms for monitoring rooftop packaged air conditioners and heat pumps (often referred to as rooftop units or RTUs) and diagnosing faults in these units, • advanced algorithms for automated fault detection and diagnosis of other equipment found in small buildings, and • algorithms for identifying, prioritizing, and assessing the economic effectiveness of implementing energy saving measures in small commercial buildings based on sensed data. The PNNL researchers involved were the original developers of these algorithms, had a unique understanding of the derivation of the algorithms, and had the source data used for this derivation. Further, the PNNL researchers had extensive experience using these algorithms in the laboratory, unique experience applying these algorithms in real-world small commercial buildings and could solve a number of key problems that NorthWrite and other users faced in using these algorithms at scale. In addition, PNNL had recently installed a pair of RTUs in a laboratory setting that were instrumented and connected with data acquisition systems that provided a unique test rig for validating the algorithms before NorthWrite began to deploy their new services in the field.

32 ENERGY CONSERVATION, CONSUMPTION, AND UTILIZATI↗

DOE OSTI2020

Development and Implementation of Fault-Correction Algorithms in Fault Detection and Diagnostics Tools

A fault detection and diagnostics (FDD) tool is a type of energy management and information system that continuously identifies the presence of faults and efficiency improvement opportunities through a one-way interface to the building automation system and the application of automated analytics. Building operators on the leading edge of technology adoption use FDD tools to enable median whole-building portfolio savings of 8%. Although FDD tools can inform operators of operational faults, currently an action is always required to correct the faults to generate energy savings. A subset of faults, however, such as biased sensors, can be addressed automatically, eliminating the need for staff intervention. Automating this fault “correction” can significantly increase the savings generated by FDD tools and reduce the reliance on human intervention. Doing so is expected to advance the usability and technical and economic performance of FDD technologies. This paper presents the development of nine innovative fault auto-correction algorithms for Heating, Ventilation, and Air Conditioning pi(HVAC) systems. When the auto-correction routine is triggered, it overwrites control setpoints or other variables to implement the intended changes. It also discusses the implementation of the auto-correction algorithms in commercial FDD software products, the integration of these strategies with building automation systems and their preliminary testing.

field testing↗

DOE OSTI2015

Proteomics of ovarian cancer: functional insights and clinical applications

In the past decade, there has been an increasing interest in applying proteomics to assist in understanding the pathogenesis of ovarian cancer, elucidating the mechanism of drug resistance, and in the development of biomarkers for early detection of ovarian cancer. Although ovarian cancer is a spectrum of different diseases, the strategies for diagnosis and treatment with surgery and adjuvant therapy are similar across ovarian cancer types, increasing the general applicability of discoveries made through proteomics research. While proteomic experiments face many difficulties which slow the pace of clinical applications, recent advances in proteomic technology contribute significantly to the identification of aberrant proteins and networks which can serve as targets for biomarker development and individualized therapies. This review provides a summary of the literature on proteomics’ contributions to ovarian cancer research and highlights the current issues, future directions, and challenges. In conclusion, we propose that protein-level characterization of primary lesion in ovarian cancer can decipher the mystery of this disease, improve diagnostic tools, and lead to more effective screening programs.

59 BASIC BIOLOGICAL SCIENCES↗

DOE OSTI2015

Understanding fuel anti-knock performances in modern SI engines using fundamental HCCI experiments

Modern spark-ignition (SI) engine technologies have considerably changed in-cylinder conditions under which fuel autoignition and engine knock take place. In this paper, fundamental HCCI engine experiments are proposed as a means for characterizing the impact of these technologies on the knock propensity of different fuels. In particular, the impacts of turbocharging, direct injection (DI), and downspeeding on operation with ethanol and gasoline are investigated to demonstrate this approach. Results reported earlier for ethanol and gasoline on HCCI combustion are revisited with the new perspective of how their autoignition characteristics fit into the anti-knock requirement in modern SI engines. For example, the weak sensitivity to pressure boost demonstrated by ethanol in HCCI autoignition can be used to explain the strong knock resistance of ethanol fuels for turbocharged SI engines. Further, ethanol's high sensitivity to charge temperature makes charge cooling, which can be produced by fuel vaporization via direct injection or by piston expansion via spark-timing retard, very effective for inhibiting knock. On the other hand, gasoline autoignition shows a higher sensitivity to pressure, so only very low pressure boost can be applied before knock occurs. Gasoline also demonstrates low temperature sensitivity, so it is unable to make as effective use of the charge cooling produced by fuel vaporization or spark retard. These arguments comprehensively explain literature results on ethanol's substantially better anti-knock performance over gasoline in modern turbocharged DISI engines. Fundamental HCCI experiments such as these can thus be used as a diagnostic and predictive tool for knock-limited SI engine performance for various fuels. As a result, examples are presented where HCCI experiments are used to identify biofuel compounds with good potential for modern SI-engine applications.

33 ADVANCED PROPULSION SYSTEMS↗

DOE OSTI2016

A micro-scale plasma spectrometer for space and plasma edge applications (invited)

A plasma spectrometer design based on advances in lithography and microchip stacking technologies is described. A series of curved plate energy analyzers, with an integrated collimator, is etched into a silicon wafer. Tests of spectrometer elements, the energy analyzer and collimator, were performed with a 5 keV electron beam. The measured collimator transmission and energy selectivity were in good agreement with design targets. A single wafer element could be used as a plasma processing or fusion first wall diagnostic.

46 INSTRUMENTATION RELATED TO NUCLEAR SCIENCE AND ↗

DOE OSTI2015

Regression Suite Improvements in MPACT

As the MPACT code has matured, the regression and validation base has grown significantly. However, the code is still undergoing advancements to the underlying methods, and improvements to the code have the possibility to change the solution. These types of methodological or data improvements should be encouraged but the requirement to rebaseline the entire regression and validation suite has recently become a daunting task which has made it more difficult to make improvements to the code. One of the objectives of this work is to streamline this process but also to provide diagnostics on the significance of the modification and the impact on several quantities of interest.

22 GENERAL STUDIES OF NUCLEAR REACTORS↗

DOE OSTI2015

Regression Suite Improvements in MPACT

22 GENERAL STUDIES OF NUCLEAR REACTORS↗

DOE OSTI2017

Advances in boronization on NSTX-Upgrade

Boronization has been effective in reducing plasma impurities and enabling access to higher density, higher confinement plasmas in many magnetic fusion devices. The National Spherical Torus eXperiment, NSTX, has recently undergone a major upgrade to NSTX-U in order to develop the physics basis for a ST-based Fusion Nuclear Science Facility (FNSF) with capability for double the toroidal field, plasma current, and NBI heating power and increased pulse duration from 1–1.5 s to 5–8 s. A new deuterated tri-methyl boron conditioning system was implemented together with a novel surface analysis diagnostic. We report on the spatial distribution of the boron deposition versus discharge pressure, gas injection and electrode location. The oxygen concentration of the plasma facing surface was measured by in-vacuo XPS and increased both with plasma exposure and with exposure to trace residual gases. Furthermore, this increase correlated with the rise of oxygen emission from the plasma.

70 PLASMA PHYSICS AND FUSION TECHNOLOGY↗

DOE OSTI2017

Advances in boronization on NSTX-Upgrade

Boronization has been effective in reducing plasma impurities and enabling access to higher density, higher confinement plasmas in many magnetic fusion devices. The National Spherical Torus eXperiment, NSTX, has recently undergone a major upgrade to NSTX-U in order to develop the physics basis for a ST-based Fusion Nuclear Science Facility (FNSF) with capability for double the toroidal field, plasma current, and NBI heating power and increased pulse duration from 1–1.5 s to 5–8 s. A new deuterated tri-methyl boron conditioning system was implemented together with a novel surface analysis diagnostic. We report on the spatial distribution of the boron deposition versus discharge pressure, gas injection and electrode location. The oxygen concentration of the plasma facing surface was measured by in-vacuo XPS and increased both with plasma exposure and with exposure to trace residual gases. This increase correlated with the rise of oxygen emission from the plasma.

70 PLASMA PHYSICS AND FUSION TECHNOLOGY↗

DOE OSTI2010

Summary Report of Working Group 5: Beam and Radiation Generation, Monitoring, and Control

This paper summarizes the activities and presentations of Working Group 5 of the Advanced Accelerator Concepts Workshop held at Annapolis, Maryland in June 2010. Working Group 5 touched on a broad range of topics in the fields of beam and radiation generation and their monitoring and control. These topics were not comprehensively covered in this Workshop, but rather the Working Group concentrated on specific new developments and recent investigations. The Working Group divided its sessions into four broad categories: cathodes and electron guns, radiation generation, beam diagnostics, and beam control and dynamics. This summary is divided into the same structure.

43 PARTICLE ACCELERATORS↗

DOE OSTI2023

Understanding Dynamics and Thermodynamics of ENSO and Its Complexity Simulated by E3SM and Other Climate Models

Despite the seeming success of most state-of-the-art climate models in simulating the El Niño-Southern Oscillation (ENSO), there is strong evidence that models achieve realistic levels of ENSO activity do so often for wrong reasons. This is owing to an often occurred near cancelation of large errors in terms of contributions to ENSO growth rate from coupled dynamic and thermodynamic feedback processes. Climate models remain deficient in simulating the observed ENSO’s spatial and temporal complexity that involves interplays of coupled dynamic and thermodynamic feedbacks, interactions across multiple scales, nonlinear processes in the tropical atmosphere and ocean system, biases in mean sate and physical processes, and influences external to equatorial Pacific coupled ENSO dynamics. Our proposed research aims at advancing predictive and process-level understandings of ENSO simulated in E3SM and other climate models under current and future climate conditions with two main objectives: (i) better understanding the aforementioned broad range interactive processes and sources that control fundamental properties of ENSO in E3SM and CIMP6 outputs as well as in observational (reanalysis) data sets, using a hierarchical of coupled dynamical frameworks consisting of theoretical analysis, intermediate complexity modeling, and coupled dynamic diagnostics; (ii) to use this understanding to explore pathways towards improving E3SM’s capability of simulating ENSO and its complexity. More specifically, we will focus on four main thrusts of research: (1) ENSO’s dynamic and thermodynamic feedbacks; (2) the across-scale interactions of ENSO with annual cycle and MJO/WWB/TIW (Madden Julian Oscillation/Westerly Wind Burst/Tropical Instability Wave) activity; (3) key nonlinear processes of ENSO involving atmospheric convective thresholds, nonlinear ocean dynamic heating, and thermocline outcropping; and (4) the impacts of climate mean-state biases/changes and perturbed physical processes on simulated ENSO and its complexity.

54 ENVIRONMENTAL SCIENCES↗

DOE OSTI2020

Global Issues of Radiopharmaceutical Access and Availability: a Nuclear Medicine Global Initiative Project

The Nuclear Medicine Global Initiative (NMGI) was formed in 2012 by 13 international organizations to promote human health by advancing the field of nuclear medicine and molecular imaging by supporting the practice and application of nuclear medicine. The first project focused on standardization of administered activities in pediatric nuclear medicine and resulted in two manuscripts. For its second project the NMGI chose to explore issues impacting on access and availability of radiopharmaceuticals around the world. Methods: Information was obtained by survey responses from 35 countries on available radioisotopes, radiopharmaceuticals and kits for diagnostic and therapeutic use. Issues impacting on access and availability of radiopharmaceuticals in individual countries were also identified. Results: Detailed information on radiopharmaceuticals utilized in each country, and sources of supply, was evaluated. Responses highlighted problems in access particularly due to the reliance on a sole provider, regulatory issues and reimbursement, as well as issues of facilities and workforce particularly in low- and middle-income countries. Conclusion: Finally, strategies to address access and availability of radiopharmaceuticals are outlined, to enable timely and equitable patient access to nuclear medicine procedures worldwide. In the face of disruptions to global supply chains by the COVID-19 outbreak, renewed focus on ensuring reliable supply of radiopharmaceuticals is a major priority for nuclear medicine practice globally.

43 PARTICLE ACCELERATORS↗

NASA NTRS1975

Lean mixture engine testing and evaluation program

Experimental results for fuel consumption and emissions are presented for a 350 CID (5.7 liter) Chevrolet V-8 engine modified for lean operation with gasoline. The lean burn engine achieved peak thermal efficiency at an equivalence ratio of 0.75 and a spark advance of 60 deg BTDC. At this condition the lean burn engine demonstrated a 10% reduction in brake specific fuel consumption compared with the stock engine; however, NOx and hydrocarbon emissions were higher. With the use of spark retard and/or slightly lower equivalence ratios, the NOx emissions performance of the stock engine was matched while showing a 6% reduction in brake specific fuel consumption. Hydrocarbon emissions exceeded the stock values in all cases. Diagnostic data indicate that lean performance in the engine configuration tested is limited by ignition delay, cycle-to-cycle pressure variations, and cylinder-to-cylinder distribution.

Dowdy, M. W.↗