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At least 145 records · Page 8
All sourcesNASA NTRSDOE OSTI
NASA NTRS2003

Flow-dependent regulation of endothelial nitric oxide synthase: role of protein kinases

Vascular endothelial cells are directly and continuously exposed to fluid shear stress generated by blood flow. Shear stress regulates endothelial structure and function by controlling expression of mechanosensitive genes and production of vasoactive factors such as nitric oxide (NO). Though it is well known that shear stress stimulates NO production from endothelial nitric oxide synthase (eNOS), the underlying molecular mechanisms remain unclear and controversial. Shear-induced production of NO involves Ca2+/calmodulin-independent mechanisms, including phosphorylation of eNOS at several sites and its interaction with other proteins, including caveolin and heat shock protein-90. There have been conflicting results as to which protein kinases-protein kinase A, protein kinase B (Akt), other Ser/Thr protein kinases, or tyrosine kinases-are responsible for shear-dependent eNOS regulation. The functional significance of each phosphorylation site is still unclear. We have attempted to summarize the current status of understanding in shear-dependent eNOS regulation.

Non-NASA Center↗
NASA NTRS1995

Gravitropic responses of the Avena coleoptile in space and on clinostats. II. Is reciprocity valid?

Experiments were undertaken to determine if the reciprocity rule is valid for gravitropic responses of oat coleoptiles in the acceleration region below 1 g. The rule predicts that the gravitropic response should be proportional to the product of the applied acceleration and the stimulation time. Seedlings were cultivated on 1 g centrifuges and transferred to test centrifuges to apply a transverse g-stimulation. Since responses occurred in microgravity, the uncertainties about the validity of clinostat simulation of weightlessness was avoided. Plants at two stages of coleoptile development were tested. Plant responses were obtained using time-lapse video recordings that were analyzed after the flight. Stimulus intensities and durations were varied and ranged from 0.1 to 1.0 g and from 2 to 130 min, respectively. For threshold g-doses the reciprocity rule was obeyed. The threshold dose was of the order of 55 g s and 120 g s, respectively, for two groups of plants investigated. Reciprocity was studied also at bending responses which are from just above the detectable level to about 10 degrees. The validity of the rule could not be confirmed for higher g-doses, chiefly because the data were more variable. It was investigated whether the uniformity of the overall response data increased when the gravitropic dose was defined as (gm x t) with m-values different from unity. This was not the case and the reciprocity concept is, therefore, valid also in the hypogravity region. The concept of gravitropic dose, the product of the transverse acceleration and the stimulation time, is also well-defined in the acceleration region studied. With the same hardware, tests were done on earth where responses occurred on clinostats. The results did not contradict the reciprocity rule but scatter in the data was large.

Flight Experiment↗
DOE OSTI2021

Utah FORGE Well 16A(78)-32 Simplified Discrete Fracture Network Data

The FORGE team is making these fracture models available to researchers wanting a set of natural fractures in the FORGE reservoir for use in their own modeling work. They have been used to predict stimulation distances during hydraulic stimulation at the open toe section of well 16A(78)-32. This is a simplified DFN (discrete fracture network) dataset, that was generated using FracMan, for Utah FORGE well 16A(78)-32. A short, well-illustrated, report describing the data is also included in the provided archive file.

15 GEOTHERMAL ENERGY↗
DOE OSTI2023

Utah FORGE: Reports on Northwestern Nevada Well Doublet Drilling and Testing by Fervo Energy

These reports review Fervo Energy's construction of a commercial enhanced geothermal system (EGS). Fervo has qualified full functionality of the system through production testing at commercially relevant operating conditions. The project site is located in a nearfield setting adjacent to an operating geothermal power station in north-central Nevada and is designed to deliver an uplift in high-temperature geothermal flow rates to increase the power capacity at the facility. The project involved drilling a first-of-a-kind EGS horizontal doublet well system consisting of an injection and production well pair within a high-temperature hard-rock geothermal formation. The lithology of the target reservoir is characterized as a mixed metasedimentary and igneous formation, comprised of phyllite, quartzite, diorite, and granodiorite, representative of the geology across the most prospective geothermal areas throughout the western US. This work included a 16-stage plug-and-perforate stimulation treatment which was the first of its kind in a high-temperature mixed metasedimentary and granitic formation in a fully horizontal doublet geothermal well.

15 GEOTHERMAL ENERGY↗
NASA NTRS1994

Metaphase yields from staphylococcal enterotoxin A stimulated peripheral blood lymphocytes of unirradiated and irradiated aged rhesus monkeys

The mitogen phytohemagglutinin (PHA) works well in both human and cynomolgus monkey (Macaca fascicularis) lymphocyte cultures to stimulate T cell proliferation. T cells from rhesus monkeys (Macaca mulatta) are less responsive than human cells, producing few metaphases when thousands are required, e.g. in biological dosimetry studies. We show that staphylococcal enterotoxin A (SEA), one of the most potent mitogens known, at a concentration of 0.5 microgram/ml stimulated peripheral lymphocytes to grow with a mitotic index (MI) averaging 0.13 metaphases/cell in old, irradiated rhesus macaques. This was significantly greater (p < 0.001) than that produced by PHA (MI < 0.01) in lymphocytes from the same animals. Whole blood was cultured for 96, 120 and 144 h for five irradiated individuals and for two controls. All cells cultured with SEA produced a high MI with a peak response at 120 h whereas the same cultures showed low MI for each PHA stimulated culture.

Non-NASA Center↗
DOE OSTI2023

Utah FORGE: Optimization of a Plug-and-Perf Stimulation (Fervo Energy)

Information around the plug-and-perf treatment design at Utah FORGE by Fervo Energy. Objective and Purpose: - Develop a multistage hydraulic stimulation approach designed specifically to target the top three factors that control the technical and commercial viability of an EGS system: i) Achieving sufficient injectivity to support high cross-well flow rates ii) Distributing flow evenly across the wellbore and reservoir to maximize heat mining efficiency, ensure sustained heat transfer, and mitigate thermal breakthrough iii) Overcoming the effects of stress heterogeneity, stress shadowing, and variations in natural fracture properties during the stimulation treatment, leading to a more predictable stimulated reservoir volume and offset well placement - The following activities will be performed: i) Design, plan, and execute a multistage plug-and-perf stimulation treatment at a Fervo site with data acquisition and well testing activities aimed at addressing key technical aspects of the issues above ii) Perform data processing and interpretation of field results to translate the results form the Fervo site to a site-specific design at the Utah FORGE site iii) Design, plan, and execute a multistage plug-and-perf stimulation treatment design at the Utah FORGE site Methods and Approach: - Design a detailed data acquisition plan to maximize learning around: i) DFIT testing ii) Petrophysical logging, image logging iii) Permanent DAS/DTS fiber optic monitoring iv) Deep borehole microseismic monitoring v) Shallow borehole induced seismicity monitoring vi) Injection/production testing (RTA analysis, tracer testing) vii) Integrated numerical modeling and production forecasting

15 GEOTHERMAL ENERGY↗
DOE OSTI2020

Creation of a Mixed-Mode Fracture Network at Mesoscale Through Hydraulic Fracturing and Shear Stimulation

Enhanced Geothermal Systems could provide a substantial contribution to the global energy demand if their implementation could overcome inherent challenges. Examples are insufficient created permeability, early thermal breakthrough, and unacceptable induced seismicity. In this study we report on the seismic response of a mesoscale hydraulic fracturing experiment performed at 1.5-km depth at the Sanford Underground Research Facility. We have measured the seismic activity by utilizing a 100-kHz, continuous seismic monitoring system deployed in six 60-m length monitoring boreholes surrounding the experimental domain in 3-D. The achieved location uncertainty was on the order of 1 m and limited by the signal-to-noise ratio of detected events. These uncertainties were corroborated by detections of fracture intersections at the monitoring boreholes. Three intervals of the dedicated injection borehole were hydraulically stimulated by water injection at pressures up to 33 MPa and flow rates up to 5 L/min. We located 1,933 seismic events during several injection periods. The recorded seismicity delineates a complex fracture network comprised of multistrand hydraulic fractures and shear-reactivated, preexisting planes of weakness that grew unilaterally from the point of initiation. We find that heterogeneity of stress dictates the seismic outcome of hydraulic stimulations, even when relying on theoretically well-behaved hydraulic fractures. Once hydraulic fractures intersected boreholes, the boreholes acted as a pressure relief and fracture propagation ceased. In order to create an efficient subsurface heat exchanger, production boreholes should not be drilled before the end of hydraulic stimulations.

58 GEOSCIENCES↗
DOE OSTI2021

TOUGH-RFPA: Coupled thermal-hydraulic-mechanical Rock Failure Process Analysis with application to deep geothermal wells

This paper presents a coupled thermal-hydraulic-mechanical (THM) model for simulating failure processes in geological media. The coupling between stress/strain and heat transfer describing how thermal expansion affects stress is based on the theory of thermo-elasticity. Additionally, the coupling between stress/strain and fluid flow describing how pore-pressure affects stress is governed by Biot's consolidation theory. Stress/strain-dependent porosity/permeability/capillary-pressure defines the influence of stress on fluid flow and thermal fields. The THM model is implemented in the solver module that links the multiphase, multicomponent fluid flow simulator TOUGH2 with the geomechanical simulator RFPA (Rock Failure Process Analysis), which is based on the concept that heterogeneity leads to non-linearity and progressive failure behavior. Capability of TOUGH-RFPA simulator was verified by two benchmark problems related to hydraulic-mechanical and thermal-mechanical response in a hollow cylinder. Then the applicability of TOUGH-RFPA was demonstrated for modeling cooling-induced damage around a very deep geothermal well with mesoscopic heterogeneous properties, which showed complex damage evolution and fracturing during well cooling and fluid pressurization.

42 ENGINEERING↗
DOE OSTI2023

Utah FORGE: 2023 Large Upscaled Discrete Fracture Network Models

This dataset includes the data and a report on the large upscaled discrete fracture network modeling done for the Utah FORGE project in 2023. The FORGE modeling team is making five discrete fracture network (DFN) realizations of a large reservoir model available to researchers. These models have been upscaled to a continuum mesh or grid at resolutions of 10 meters and 20 meters providing reservoir properties for fracture porosity, permeability, and compressibility. The models are available in both the reference global coordinate frame and a local coordinate frame aligned with principal stress directions.

15 GEOTHERMAL ENERGY↗
NASA NTRS1987

Nonlinear dynamics, chaos and complex cardiac arrhythmias

Periodic stimulation of a nonlinear cardiac oscillator in vitro gives rise to complex dynamics that is well described by one-dimensional finite difference equations. As stimulation parameters are varied, a large number of different phase-locked and chaotic rhythms is observed. Similar rhythms can be observed in the intact human heart when there is interaction between two pacemaker sites. Simplified models are analyzed, which show some correspondence to clinical observations.

Glass, L.↗
NASA NTRS1994

Experiment K-7-23: Effect of Spaceflight on Level and Function of Immune Cells: Proliferation and Cytokines - Part 2

Lymphocytes from the superficial inguinal lymph nodes of rats flown on the Cosmos 2044 space mission were tested for proliferation in response to polyclonal activators. Cells were cultured with T or B cell mitogens, phorbol ester and calcium ionophore, or T cell mitogen and the lymphokines interleukin-1 (IL-1) or interleukin-2 (IL-2), and assayed for DNA synthesis by (3)H-thymidine incorporation. Lymphocytes also were incubated with concanavalin A (Con A), a T cell mitogen, and tested for IL-2 production. Mitogen-stimulated proliferation of lymphocytes from rats exposed to microgravity was not significantly different from synchronous or vivarium controls. Responses to Con A and IL-2, and Con A and IL-1 likewise were unaffected by space flight. Lymphocytes from all of these groups responded well to phorbol ester and calcium ionophore stimulation. Furthermore, lymph node cells (LNC) from control rats and rats flown on Cosmos 2044 produced similar amounts of IL-2. The results obtained using hindlimb suspended rats were notably different from those of flight and control animals. LNC from suspended rats generally had greater proliferative responses to T cell mitogens than did lymphocytes from other groups. Responsiveness to a B cell mitogen was not enhanced. Con A-stimulated LNC from hindlimb suspended rats also produced more IL-2 than did lymphocytes from the other groups. This difference was statistically significant at both IL-2 induction times tested.

Nash, P. V.↗
DOE OSTI2023

Development of fracture diagnostic methods for fluid distribution based on quantitative interpretation of distributed acoustic sensing and distributed temperature sensing

Multistage hydraulic fracturing design on horizontal wells has significantly evolved with larger fluid volume, more fracturing stages, and tighter perforation cluster spacing to efficiently stimulate unconventional reservoirs. From the published field observations, the recent fracturing design results in complex fracture networks or swarm of fractures. Fracture treatment evaluation is extremely challenging in such a case because of the large amount of variables in well completion and stimulation design. Combined measurements from different technologies can help in fracture diagnosis. Fluid distribution, either during fracture injection or during production, directly relates to the stimulation efficiency at the cluster level and at the stage level. Because it is unlikely in the real world to distribute the injected fluid uniformly among all the clusters, we need diagnostic techniques to generate the flow profile along a lateral. Fiber-optic measurements, such as distributed acoustic sensing (DAS) and distributed temperature sensing (DTS), are currently used to diagnose downhole flow conditions. This technology allows us to qualitatively confirm the fluid flow profile and other issues occurring downhole during fracturing such as leakage through plugs. For optimizing a fracturing design, we also need to understand how the design parameters are correlated with the stimulation efficiency. In this study, we combine two sets of models of DAS and DTS data interpretation for injected fluid volume distribution. The DAS is interpreted based on an empirical correlation between fluid flow rates and frequency band energy from the acoustic signals. The DTS is interpreted by performing temperature history match-based thermal energy conservation. Because of the completely different physics behind the interpretations, the confirmation of two interpretations provides confidence in fluid distribution.

Geochemistry & Geophysics↗
DOE OSTI2021

Geochemical reactions and alteration of pore architecture in saturated shale after injection of stimulation fluid

Pore architecture regulates fluid flow between unconventional shale reservoir and hydraulically-induced fractures. Imbibition of stimulation fluid may change this architecture and alter hydrocarbon flow. Hydrothermal experiments were conducted at reservoir conditions (125 °C, 45 MPa) to test two hypotheses: 1) Shale, not stimulation fluid, dominates the geochemistry of an unconventional reservoir containing formation water; and 2) Mineral dissolution and precipitation induced by stimulation fluid is transient and manifests across micro-, meso-, and macro-scales of pore architecture. Experiments replicated a shut-in well in the Cretaceous Baxter Shale, Green River Basin, Wyoming USA. Stimulation fluid was injected into one experiment after formation water (I = 0.35 mol/kg, pH = 6.4) and core reacted for 48 days. This novel approach equilibrated rock and formation water and saturated pores with formation water before introducing stimulation fluid. The second experiment served as a control. Trends of aqueous calcium, silica and aluminum in the injection experiment suggest transient dissolution of calcite and feldspar and/or quartz as well as clay and barite precipitation; mineralogic evidence was limited to calcite dissolution and barite precipitation. The rock maintained reducing conditions (Eh = +0.08 to -0.16 V) despite injection of oxidizing stimulation fluid (Eh = 1.1 V). pH of the stimulation fluid-formation water mixture evolved from 2.3 to pre-injection values (~6) within 24 h. The results indicate that mineral dissolution and precipitation manifest in macropores with barely detectable alteration to micro- and mesopores. Formation water or organic matter in pores may have inhibited access of stimulation fluid to micro- and mesopores

37 INORGANIC, ORGANIC, PHYSICAL, AND ANALYTICAL CH↗
NASA NTRS1994

Relativistic induced Compton scattering in synchrotron self-absorbed sources

We present a model of the radio emission from synchrotron self-absorbed sources, including the effects of induced Compton scattering by the relativistic electrons in the source. Order of magnitude estimates show that stimulated scattering becomes the dominant absorption process when (kT(sub B)/m(sub e) c(exp 2))Tau(sub T) greater than or approximately 1.0. Numerical simulations demonstrate that relativistic induced Compton scattering limits the brightness temperature of a self-absorbed synchroton sources to T(sub B) less than or approximately 2 x 10(exp 11) nu(exp -1/p + 3) (sub zero, 9) gamma(exp p + 2/p + 5) (sub min) K, where gamma(sub min) is the low-energy cutoff to the relativistic electron distribution with a power-law index of p. It can also significantly flatten the radio spectrum. The radio spectrum of the core of 3C 279 is well matched by a model in which stimulated scattering is important, and the additional constraint T(sub B) less than 2 x 10(exp 11)K may be important to the interpretation of the broadband spectra in variable extragalactic compact radio sources. Stimulated scattering reduces the amplitude of the radio frequency variability relative to the X-ray variability, an effect which can be detected by multiwavelength variability studies. Data for a sample of resolved compact radio cores indicate that it is inconsistent to neglect induced Compton scattering when inferring the physical parameters of the sources. The necessary generalizations to the standard synchrotron self-Compton theory are p resented.

Sincell, Mark W.↗
DOE OSTI2022

Induced microearthquakes predict permeability creation in the brittle crust

Predicting the evolution of permeability accurately during stimulation at the reservoir scale and at the resolution of individual fractures is essential to characterize the fluid transport and the reactive/heat-transfer characteristics of reservoirs where stress exerts significant control. Here, we develop a hybrid machine learning (ML) model to visualize in situ permeability evolution for an intermediate-scale (~10 m) hydraulic stimulation experiment. This model includes an ML model that was trained using the well history of flow rate and wellhead pressure and MEQ data from the first three stimulation episodes to predict average permeability from the statistical features of the MEQs alone for later episodes. Moreover, a physics-inspired model is integrated to estimate in situ fracture permeability spatially. This method relates fracture permeability to fracture dilation and scales dilation to the equivalent MEQ magnitude, according to laboratory observations. The seismic data are then applied to define incremental changes in permeability in both space and time. Our results confirm the excellent agreement between the ground truth and model-predicted permeability evolution. The resulting permeability map defines and quantifies flow paths in the reservoir with the averaged permeability comparing favorably with the ground truth of permeability.

induced seismicity↗
NASA NTRS1989

Human mononuclear cell function after 4 C storage during 1-G and microgravity conditions of spaceflight

To investigate the possibility of restoring immune competence of crewmembers during a prolonged spaceflight by infusions of autologous blood components, the effect of storage at 4 C aboard Space Shuttle Columbia (Mission 61-c) on the activity of human peripheral blood mononuclear cells (PBMNCs), stored as leukocyte concentrates in autologous plasa, was investigated. The results of preflight storage at 4 C demonstrated a progressive daily loss in mitogen-stimulated protein synthesis, and thymidine uptake, as well as a progressive reduction in the percentage of PBMNCs expressing cell-surface phenotype markers. The ability of PBMNCs stored at 4 C for 8 d in Columbia's middeck, to become activated and proliferate in vitro was similar to that of cells that remained for 7 d on ground.

Meehan, Richard↗
NASA NTRS1995

Speed Discrimination: Multiple Stimuli Appear Better Than One

We reported that for a 21FC task with multiple moving grating patches (Gabors) in each interval, thresholds for speed discrimination decreased with the number of patches, while increasing the area of a single grating produced no such effect. Furthermore, this decrease occurred regardless of the spacing of the patches about a circle of eccentricity 4 degrees, i.e., whether they were maximally separated or almost touching. These results suggest that it is the multiple, discrete grating patches that cause thresholds to decrease, rather than the spatial arrangement. To test this hypothesis, we measured the effect of dividing a large grating into four quadrants, by superimposing a mean-luminance cross on it. The mean speed discrimination thresholds (Weber Fractions) for four observers were 19, 15, and 11 plus or minus 2%, for the single large grating, the grating with cross, and the 4 maximally-separated, small gratings, respectively. Thus, breaking up a single large grating into multiple parts caused thresholds to improve, despite the fact that less of the original patch was visible. To investigate the possible contribution of total bounding contour length, we measured the effect of coalescing three small grating patches into a single banana-shaped patch, while keeping the total contour length constant. These two conditions were compared to a single, circular Gabor patch of equivalent area that had (necessarily) a smaller contour length. Preliminary data from 3 of 4 observers were similar for the small-grating and banana configurations, but increased for the single, large grating, suggesting that contour length might play a role. We are also investigating the role of low-level factors pertinent to the large grating, such as the pooling of signals from motion units at different eccentricities, and the stimulation of extended inhibitory motion surrounds, as well as the possible contribution of topdown influences that segment the stimulus into distinct objects.

Verghese, Preeti↗
NASA NTRS2000

Cardiovascular response to lower body negative pressure stimulation before, during, and after space flight

BACKGROUND: It is well known that space travel cause post-flight orthostatic hypotension and it was assumed that autonomic cardiovascular control deteriorates in space. Lower body negative pressure (LBNP) was used to assess autonomic function of the cardiovascular system. METHODS: LBNP tests were performed on six crew-members before and on the first days post-flight in a series of three space missions. Additionally, two of the subjects performed LBNP tests in-flight. LBNP mimics fluid distribution of upright posture in a gravity independent way. It causes an artificial sequestration of blood, reduces preload, and filtrates plasma into the lower part of the body. Fluid distribution was assessed by bioelectrical impedance and anthropometric measurements. RESULTS: Heart rate, blood pressure, and total peripheral resistance increased significantly during LBNP experiments in-flight. The decrease in stroke volume, the increased pooling of blood, and the increased filtration of plasma into the lower limbs during LBNP indicated that a plasma volume reduction and a deficit of the interstitial volume of lower limbs rather than a change in cardiovascular control was responsible for the in-flight response. Post-flight LBNP showed no signs of cardiovascular deterioration. The still more pronounced haemodynamic changes during LBNP reflected the expected behaviour of cardiovascular control faced with less intravascular volume. In-flight, the status of an intra-and extravascular fluid deficit increases sympathetic activity, the release of vasoactive substances and consequently blood pressure. Post-flight, blood pressure decreases significantly below pre-flight values after restoration of volume deficits. CONCLUSION: We conclude that the cardiovascular changes in-flight are a consequence of a fluid deficit rather than a consequence of changes in autonomic signal processing.

manned↗