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All sourcesNASA NTRSDOE OSTI
NASA NTRSDate not supplied

Investigation of Prophage Regions of Bacterial Strains Isolated from the International Space Station (ISS)

Space flight agencies are planning missions back to the Moon and to Mars. When sending humans into space, it is impossible to separate them from microorganisms, either in their associated microbiome or in the spacecraft environment, which are modified through the movement of genetic material. Bacteriophages, small viruses that invade and replicate within bacterial cells, play a central role in the genetic composition and evolution of microorganisms. Lysogenic bacteriophages can insert themselves into the DNA of their bacterial hosts, forming prophage regions, which can also transfer genes from previous hosts. Thus, we aimed to identify and classify all prophages from twelve bacterial species cultured from the International Space Station (ISS) from 2017 to 2018. We determined representative bacterial strains for each species, whose genomes were analyzed to identify prophage regions. Complete prophages were identified through database searches and the number of prophage regions were compared to terrestrial analogs. Additionally, prophage region and genome sizes were compared for each species, identifying the percentage of bacteriophage DNA in each genome. We determined that the prophage-susceptible bacterial species isolated from the ISS had a higher number of prophage regions when compared to terrestrial analogs, as well as having a larger percentage of their genomes made up of prophage material. Of the eighteen complete prophages identified, 72.2% were of family Siphoviridae and 27.8% were of family Myoviridae. Only one of the prophages had a BLAST similarity over 80%, suggesting that the remainder of prophages are novel species. These results imply that there is a higher rate of prophage transduction and lysogeny during spaceflight, and that the prophages present are novel.

Phage↗
NASA NTRS2002

A Plasma Rocket Demonstration on the International Space Station

The Advanced Space Propulsion Laboratory at the NASA Johnson Space Center has been engaged in the development of a magneto-plasma rocket for several years. This type of rocket could be used in the future to propel interplanetary spacecraft. One feature of this concept is the ability to vary its specific impulse so that it can be operated in a mode that maximizes propellant efficiency or a mode that maximizes thrust. For this reason the system is called the Variable Specific Impulse Magneto-plasma Rocket or VASIMR. This ability to vary specific impulse and thrust will allow for optimum low thrust interplanetary trajectories and results in shorter trip times than is possible with fixed specific impulse systems while preserving adequate payload margins. In the development of the VASIMR technology, a series of ground-based experiments and space demonstrations are envisioned. A ground-based experiment of a low-power VASIMR prototype rocket is currently underway at the Advanced Space Propulsion Laboratory. The next step is a proposal to build and fly a 25-kilowatt VASIMR rocket as an external payload on the International Space Station. This experiment will provide an opportunity to demonstrate the performance of the rocket in space and measure the induced environment. The experiment will also utilize the space station for its intended purpose as a laboratory with vacuum conditions that cannot be matched by any laboratory on Earth. The VASIMR experiment will also blaze the trail for the wider application of advanced electric propulsion on the space station. An electric propulsion system like VASIMR, if provided with sufficient electrical power, could provide continuous drag force compensation for the space station. Drag compensation would eliminate the need for reboosting the station, an operation that will consume about 60 metric tons of propellant in a ten-year period. In contrast, an electric propulsion system would require very little propellant. In fact, a system like VASIMR can use waste hydrogen from the station's life support system as its propellant. This waste hydrogen is otherwise dumped overboard. Continuous drag compensation would also improve the microgravity conditions on the station. So electric propulsion can reduce propellant delivery requirements and thereby increase available payload capacity and at the same time improve the conditions for scientific research.

Petro, Andrew J.↗
NASA NTRS1991

Task-analytic evaluations of Space Station Freedom workstations

Space Station Freedom will be a permanently manned multipurpose facility in low Earth orbit by the late 1990's. Integral to Space Station Freedom will be Data Management System workstations. These workstations will provide the human-machine interface for controlling such systems as Guidance, Navigation and Control, Propulsion, and Environmental Control and Life Support. In addition, they will be used by crewmembers in the space station's pressurized shirt-sleeve environment to control remote manipulator systems and free-flyer devices. This paper presents an overview of proposed workstations and current task-analytic evaluations being used to assess their adequacy in supporting Space Station Freedom operations. Particular emphasis is placed on the results and conclusions of the analysis.

Diaz, Manuel F.↗
NASA NTRS2003

Space Station Science Supported by Marshall Space Flight Center

The science program at Marshall Space Flight Center will be reviewed in the context of the overall NASA science program. An overview will be given on how Marshall science supports the International Space Station research program. The Microgravity research capabilities at Marshall's Biological and Physical Space Research Laboratory will be reviewed. The environment in orbit provides a unique opportunity to study Materials Science and Biotechnology in the absence of sedimentation and convection. There are a number of peer-selected investigations that have been selected to fly on the Space Station that have been conceived and are led by Marshall civil service and contractor scientists. In addition to Microgravity research the Station will enable research in New Initiative Research Areas that focus on enabling humans to live, work, and explore the solar system safely. The specific scientific instruments that have been developed for Materials Science and Biotechnology Research on the International Space Station will be discussed.

Whitaker, Ann F.↗
NASA NTRS1992

A facility for training Space Station astronauts

The Space Station Training Facility (SSTF) will be the primary facility for training the Space Station Freedom astronauts and the Space Station Control Center ground support personnel. Conceptually, the SSTF will consist of two parts: a Student Environment and an Author Environment. The Student Environment will contain trainers, instructor stations, computers and other equipment necessary for training. The Author Environment will contain the systems that will be used to manage, develop, integrate, test and verify, operate and maintain the equipment and software in the Student Environment.

Hajare, Ankur R.↗
NASA NTRS1983

Space Station needs, attributes and architectural options. Volume 2, book 1, part 3: Manned Space Station relevance to commercial telecommunications satellites

A document containing a forecast of satellite traffic and revelant technology trends to the year 2000 was prepared which includes those space station capabilities and characteristics that should be provided to make the station useful to commercial satellite owners. The document was circulated to key representative organizations within the commercial telecommunications satellite and related communities of interest, including spacecraft manufacturers, commercial satellite owners, communications carriers, networks and risk insurers. The prospectus document is presented as well as the transmittal letter and the mailing list of the people and companies that were asked to review it. Key commercial telecommunications comments are summarized the actual response letters from the industry are included.

Source record↗
NASA NTRS2003

International Space Station (ISS) Expedite the Process of Experiments to Space Station (EXPRESS) Racks Software Support

bd Systems personnel accomplished the technical responsibilities for this reporting period, as planned. A close working relationship was maintained with personnel of the MSFC Avionics Department Software Group (ED 14), the MSFC EXPRESS Project Office (FD3 l), and the Huntsville Boeing Company. Work accomplishments included the support of SRB activities, ATB activities, ESCP activities, participating in technical meetings, coordinating issues between the Boeing Company and the MSFC Project Office, and performing special tasks as requested.

Source record↗
NASA NTRS2012

The International Space Station: Unique In-Space Testbed as Exploration Analog

Final assembly of the International Space Station (ISS) was completed in 2011. As articulated in the 2011 NASA Strategic Plan, the Agency's first goal is to extend and sustain human activities across the solar system. Thus, the emerging NASA vision is to launch a bold and ambitious new space initiative to enable human space exploration beyond low-Earth orbit to Lagrange points, the moon, near-Earth asteroids (NEAs), and Mars and its environs. To accomplish this vision, it is necessary to develop and validate innovative exploration technologies and operational concepts. With the extended life of the ISS to 2020 and possibly 2028, NASA has a mandate to maximize the potential of the Nation's newest National Laboratory. Exploration and ISS teams within NASA's Human Exploration and Operations Mission Directorate (HEOMD) have initiated a cooperative effort: the ISS Testbed for Analog Research (ISTAR), a high-fidelity operational analog that complements existing NASA terrestrial laboratory and field testing. To maximize use of the ISS platform to evaluate new exploration technologies, capabilities, and operational concepts to better comprehend and mitigate human spaceflight risks, ISTAR seeks out and encourages investigations dubbed "exploration detailed test objectives" (xDTOs). These xDTOs, building blocks of ISTAR missions, develop and optimize the operations concepts and the use of new technologies that should reduce risks and challenges facing astronauts on long exploration spaceflight voyages. In this paper, we describe (1) the rationale behind ISTAR, (2) a five-year strategic plan, (3) the approach for mission formulation, development, integration, and execution, (4) concepts for near-term missions that implement a phased approach for using ISS as an exploration testbed, and (5) the planned Mars mission simulation using the ISS. This paper will also document several challenges ISTAR must address to execute its missions.

Analog Mission↗
NASA NTRS1985

Preparing a health care delivery system for Space Station

NASA's Space Station is viewed as the beginning of man's permanent presence in space. This paper presents the guidelines being developed by NASA's medical community in preparing a quality, permanent health care delivery system for Space Station. The guidelines will be driven by unique Space Station requirements such as mission duration, crew size, orbit altitude and inclination, EVA frequency and rescue capability. The approach will emphasize developing a health care system that is modular and flexible. It will also incorporate NASA's requirements for growth capability, commonality, maintainability, and advanced technology development. Goals include preventing unnecessary rescue attempts, as well as maintaining the health and safety of the crew. Proper planning will determine the levels of prevention, diagnosis, and treatment necessary to achieve these goals.

Logan, J. S.↗
NASA NTRS1983

The Alpha-Helix Concept: Innovative utilization of the Space Station Program. A report to the National Aeronautical and Space Administration requesting establishment of a Sensory Physiology Laboratory on the Space Station

A major laboratory dedicated to biological-medical research is proposed for the Space Platform. The laboratory would focus on sensor physiology and biochemistry since sensory physiology represents the first impact of the new space environment on living organisms. Microgravity and the high radiation environment of space would be used to help solve the problems of prolonged sojourns in space but, more importantly, to help solve terrestrial problems of human health and agricultural productivity. The emphasis would be on experimental use of microorganisms and small plants and small animals to minimize the space and time required to use the Space Platform for maximum human betterment. The Alpha Helix Concept, that is, the use of the Space Platform to bring experimental biomedicine to a new and extreme frontier is introduced so as to better understand the worldly environment. Staffing and instrumenting the Space Platform biomedical laboratory in a manner patterned after successful terrestrial sensory physiology laboratories is also proposed.

Bandurski, R. S.↗
NASA NTRS1982

Architectural options for space stations in the context of the space infrastructure

The role of space stations in the space element infrastructure anticipated for the end of the 20th century is discussed. Various architectures for space stations designed to function as part of the infrastructure are examined with respect to a set of potential objectives for the stations. Architectural options are described that range from a minimum station of low capability and cost to an expensive station with a full operations capability and high growth potential. The capabilities, growth potentials, and likely costs of the options are compared, and the association between functional capabilities and likely cost is considered. It is concluded that the cost of a space station is intimately related to its architecture and that a larger initial investment must be made to satisfy more ambitious objectives.

Bekey, I.↗
NASA NTRS1970

An overview of NASA's Space Station program

NASA space station program, discussing relationship between space stations, Skylab and space shuttle, electric power generation, habitability, safety and communications networks

Lohman, R. L.↗
NASA NTRS1992

Gravitational Biology Facility on Space Station: Meeting the needs of space biology

The Gravitational Biology Facility (GBF) is a set of generic laboratory equipment needed to conduct research on Space Station Freedom (SSF), focusing on Space Biology Program science (Cell and Developmental Biology and Plant Biology). The GBF will be functional from the earliest utilization flights through the permanent manned phase. Gravitational biology research will also make use of other Life Sciences equipment on the space station as well as existing equipment developed for the space shuttle. The facility equipment will be developed based on requirements derived from experiments proposed by the scientific community to address critical questions in the Space Biology Program. This requires that the facility have the ability to house a wide variety of species, various methods of observation, and numerous methods of sample collection, preservation, and storage. The selection of the equipment will be done by the members of a scientific working group (5 members representing cell biology, 6 developmental biology, and 6 plant biology) who also provide requirements to design engineers to ensure that the equipment will meet scientific needs. All equipment will undergo extensive ground based experimental validation studies by various investigators addressing a variety of experimental questions. Equipment will be designed to be adaptable to other space platforms. The theme of the Gravitational Biology Facility effort is to provide optimal and reliable equipment to answer the critical questions in Space Biology as to the effects of gravity on living systems.

Allen, Katherine↗
NASA NTRS1992

Utilization of Space Station Freedom for technology research

Space Station Freedom presents a unique opportunity for technology developers to conduct research in the space environment. Research can be conducted in the pressurized volume of the Space Station's laboratories or attached to the Space Station truss in the vacuum of space. Technology developers, represented by the Office of Aeronautics and Space Technology (OAST), will have 12 percent of the available Space Station resources (volume, power, data, crew, etc.) to use for their research. Most technologies can benefit from research on Space Station Freedom and all these technologies are represented in the OAST proposed traffic model. This traffic model consists of experiments that have been proposed by technology developers but not necessarily selected for flight. Experiments to be flown in space will be selected through an Announcement of Opportunity (A.O.) process. The A.O. is expected to be released in August, 1992. Experiments will generally fall into one of the 3 following categories: (1) Individual technology experiments; (2) Instrumented Space Station; and (3) Guest investigator program. The individual technology experiments are those that do not instrument the Space Station nor directly relate to the development of technologies for evolution of Space Station or development of advanced space platforms. The Instrumented Space Station category is similar to the Orbiter Experiments Program and allows the technology developer to instrument subsystems on the Station or develop instrumentation packages that measure products or processes of the Space Station for the advancement of space platform technologies. The guest investigator program allows the user to request data from Space Station or other experiments for independent research. When developing an experiment, a developer should consider all the resources and infrastructure that Space Station Freedom can provide and take advantage of these to the maximum extent possible. Things like environment, accommodations, carriers, and integration should all be taken into account. In developing experiments at Langley Research Center, an iterative approach is proving useful. This approach uses Space Station utilization and subsystem experts to advise and critique experiment designs to take advantage of everything the Space Station has to offer. Also, solid object modeling and animation computer tools are used to fully visualize the experiment and its processes. This process is very useful for attached payloads and allows problems to be detected early in the experiment design phase.

Avery, Don E.↗
NASA NTRS1992

Lunar base mission technology issues and orbital demonstration requirements on space station

The International Space Station has been the object of considerable design, redesign, and alteration since it was originally proposed in early 1984. In the intervening years the station has slowly evolved to a specific design that was thoroughly reviewed by a large agency-wide Critical Evaluation Task Force (CETF). As space station designs continue to evolve, studies must be conducted to determine the suitability of the current design for some of the primary purposes for which the station will be used. This paper concentrates on the technology requirements and issues, the on-orbit demonstration and verification program, and the space station focused support required prior to the establishment of a permanently manned lunar base as identified in the National Commission on Space report. Technology issues associated with the on-orbit assembly and processing of the lunar vehicle flight elements are also discussed.

Llewellyn, Charles P.↗