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At least 145 records · Page 8

Lightweight Composite Reflectarray That Can Be Flattened, Folded, and Coiled for Compact Stowage

Herein is presented a design for a lightweight 5m 1m radio-frequency (RF) re ector that can be attened, folded, and coiled for compact stowage on board an ESPA-class spacecraft. The re ector is a re ectarray that operates at 3.2GHz. Compared to state- of-the-art technologies for RF re ectors, the presented design has advantages in terms of areal density, sti ness, deployed stability, and scalability. Thermal and structural analysis is presented to demonstrate deployed sti ness and thermoelastic stability of the proposed design. Thermal analysis is used to predict in- space deployed temperatures in an operational condition, and structural nite element analysis is used to predict deployed vibration modes and frequencies, and the thermoelastic deformation of the deployed re ector. Also presented are the fabrication, assembly, and testing of two one-third-scale-length full-scale-width 1:7m 1m test articles. These test articles are used to experimentally demonstrate RF functioning, stowage, deployment, and RF performance after deployment.

Pellegrino, Sergio↗

Segmented, Pleat-Folded and Rib-Supported Thin-Shell Composite Antenna Reflector

A new architecture scalable to sizes greater than 10 m for a deployable solid surface reflector antenna is presented. The design makes use of radially and circumferentially segmented thin-shell composite gores interconnected on the back side by a series of flexible shape memory composite elements. The reflector surface stows like an umbrella by creating serpentine-shaped pleats in the thin shell while being supported by a simple-hinged metering rib structure. A parametric study assessed how design features affect the deployed stiffness of the reflector and are used to identify a test matrix for manufacturing, foldability, and shape accuracy assessments. Various manufacturing tooling designs and dedicated folding fixtures were built to increase the fidelity and confidence of the test articles produced. An overview of the development effort is provided.

Deployable antennas↗

Segmented, Pleat-Folded and Rib-Supported Thin-Shell Composite Antenna Reflector

A new architecture scalable to sizes greater than 10 m for a deployable solid surface reflector antenna is presented. The design makes use of radially and circumferentially segmented thin-shell composite gores interconnected on the back side by a series of flexible shape memory composite elements. The reflector surface stows like an umbrella by creating serpentine-shaped pleats in the thin shell while being supported by a simple-hinged metering rib structure. A parametric study assessed how design features affect the deployed stiffness of the reflector and are used to identify a test matrix for manufacturing, foldability, and shape accuracy assessments. Various manufacturing tooling designs and dedicated folding fixtures were built to increase the fidelity and confidence of the test articles produced. An overview of the development effort is provided.

Deployable antennas↗

Giant Enhancement of Four-Wave Mixing by Doubly Zone-Folded Nonlocal Metasurfaces

Resonant optical metasurfaces hold promise for enhancing nonlinear optical signals and manipulating their fundamental properties. However, they rarely excel at amplifying signals from nonlinear processes with two incident pump beams, such as four-wave mixing (FWM) or sum-frequency generation. Frequency-mixing experiments impose challenging requirements for metasurface design due to the need to support multiple optical resonances with compatible field profiles at specified resonant wavelengths, often across a substantial spectral separation. Here, in this work, we introduce nonlocal ‘quadromer’ metasurfaces containing four nanostructures per unit cell as the key to unlocking configurable, multiresonant metasurfaces that enhance frequency-mixing processes. As a proof of concept, we experimentally demonstrate enhanced FWM using quadromer metasurfaces made of silicon and silicon-rich silicon nitride. The results are relevant for applications such as imaging of infrared light upconverted into the visible spectrum and the generation of quantum light via spontaneous FWM.

four-wave mixing↗

Birth of protein folds and functions in the virome

The rapid evolution of viruses generates proteins that are essential for infectivity and replication but with unknown functions, due to extreme sequence divergence. Here, using a database of 67,715 newly predicted protein structures from 4,463 eukaryotic viral species, we found that 62% of viral proteins are structurally distinct and lack homologues in the AlphaFold database. Among the remaining 38% of viral proteins, many have non-viral structural analogues that revealed surprising similarities between human pathogens and their eukaryotic hosts. Structural comparisons suggested putative functions for up to 25% of unannotated viral proteins, including those with roles in the evasion of innate immunity. In particular, RNA ligase T-like phosphodiesterases were found to resemble phage-encoded proteins that hydrolyse the host immune-activating cyclic dinucleotides 3',3'- and 2',3'-cyclic GMP-AMP (cGAMP). Experimental analysis showed that RNA ligase T homologues encoded by avian poxviruses similarly hydrolyse cGAMP, showing that RNA ligase T-mediated targeting of cGAMP is an evolutionarily conserved mechanism of immune evasion that is present in both bacteriophage and eukaryotic viruses. Together, the viral protein structural database and analyses presented here afford new opportunities to identify mechanisms of virus–host interactions that are common across the virome.

59 BASIC BIOLOGICAL SCIENCES↗

Cryo-EM confirms a common fibril fold in the heart of four patients with ATTRwt amyloidosis

ATTR amyloidosis results from the conversion of transthyretin into amyloid fibrils that deposit in tissues causing organ failure and death. This conversion is facilitated by mutations in ATTRv amyloidosis, or aging in ATTRwt amyloidosis. ATTRv amyloidosis exhibits extreme phenotypic variability, whereas ATTRwt amyloidosis presentation is consistent and predictable. Previously, we found unique structural variabilities in cardiac amyloid fibrils from polyneuropathic ATTRv-I84S patients. In contrast, cardiac fibrils from five genotypically different patients with cardiomyopathy or mixed phenotypes are structurally homogeneous. To understand fibril structure’s impact on phenotype, it is necessary to study the fibrils from multiple patients sharing genotype and phenotype. Here we show the cryo-electron microscopy structures of fibrils extracted from four cardiomyopathic ATTRwt amyloidosis patients. Our study confirms that they share identical conformations with minimal structural variability, consistent with their homogenous clinical presentation. Our study contributes to the understanding of ATTR amyloidosis biopathology and calls for further studies.

59 BASIC BIOLOGICAL SCIENCES↗

Spin–orbit torque in a three-fold-symmetric bilayer and its effect on magnetization dynamics

Field-free switching of perpendicular magnetization has previously been observed in an epitaxial L1 1 -ordered CoPt/CuPt bilayer and attributed to spin–orbit torque (SOT) arising from the crystallographic 3m point group of the interface. Using a first-principles nonequilibrium Green's function formalism combined with the Anderson disorder model, we calculate the angular dependence of the SOT in a CoPt/CuPt bilayer and find that the magnitude of the 3m SOT is about 20% of the conventional dampinglike SOT. We further study the magnetization dynamics in perpendicularly magnetized films in the presence of 3m SOT and Dzyaloshinskii–Moriya interaction, using the equations of motion for domain wall dynamics and micromagnetic simulations. For systems where strong interfacial DMI results in the Néel character of domain walls, we find that a very large current density is required to achieve deterministic switching, because reorientation of the magnetization inside the domain wall is necessary to induce the switching asymmetry. For thicker films with relatively weak interfacial DMI and the Bloch character of domain walls, deterministic switching is possible at much smaller current densities, which may explain the recent experimental findings.

75 CONDENSED MATTER PHYSICS, SUPERCONDUCTIVITY AND↗

Greater than 1000-fold Gain in a Free-Electron Laser Driven by a Laser-Plasma Accelerator with High Reliability

Compact free-electron lasers (FELs) based on plasma-based accelerators have been envisioned for many years. While recent milestone experiments have demonstrated feasibility, further progress is needed to establish laser-plasma-accelerator-driven FELs as reliable light sources. Demonstrating both full FEL saturation and reliable operation commensurate with conventional FEL facilities is critical. We report progress on both of these fronts. FEL gain exceeding 1000 at a wavelength of 420 nm in the self-amplified spontaneous emission regime has been measured. Lower and upper bounds for the characteristic exponential gain length were measured at 16.7-22.5 cm. Additionally, reliability of the laser-plasma-accelerator-driven FEL, defined here as the percentage of shots displaying FEL gain, reached an unprecedented level of greater than 90% over the course of an hour while operating at 1 Hz repetition rate.

Barber, S K↗

Diversity in the Common Fold: Structural Insights into Class D β-Lactamases from Gram-Negative Pathogens

Class D β-lactamases (DBLs) represent a major threat to antibiotic efficacy by hydrolyzing β-lactam drugs, including last-resort carbapenems, thereby driving antimicrobial resistance in Gram-negative bacteria. The enzymes share a structurally conserved two-domain α/β architecture with seven active-site motifs and three flexible extended loops (the P-loop, Ω-loop, and newly designated B-loop) that surround the active site. While each of these loops is known to influence enzyme function, their coordinated roles have not been fully elucidated. To investigate the significance of their interplay, we compared the sequences and crystal structures of 40 DBLs from clinically relevant Gram-negative pathogens and performed molecular dynamics simulations on selected representatives. Combined structural and dynamical analyses revealed a strong correlation between B-loop architecture and carbapenemase activity in the pathogens Klebsiella and Acinetobacter, particularly regarding loop length and spatial organization. These findings emphasize the B-loop’s critical contribution, in concert with the P- and Ω-loops, in tuning active site versatility, substrate recognition, catalytic activity, and structural stability. A deeper understanding of how these motifs and loops govern DBL function may inform the development of novel antibiotics and inhibitors targeting this class of enzymes.

antibiotic resistance↗

Metal tube can be folded for compact stowage, is self-erecting

Metal tube configuration reduces the section modulus to that of a thin plate, thus permitting the section to be bent into a coil for stowage in limited space without destructive yielding of the material. It is readily released to serve as a rigid fluid transportation conduit or structural member.

Source record↗