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At least 145 records · Page 8

Validation of pooling strategies of clinical COVID-19 samples for more efficient diagnostic testing

Pooling of COVID-19 clinical samples can offer significant reduction in reagents, time, and labor needed to test large numbers of clinical samples. Especially for testing asymptomatic and return-towork/ school cases, where the prevalence of COVID-19 may be relatively low, large groups of clinical samples can be classified as negative with a single test, with no need to test every sample individually. LANL has performed validation for two different pooling strategies to assess diagnostic assay sensitivity in pooled samples compared to the clinical positive sample alone. (1) Pooling study - Determine diagnostic assay sensitivity in pooled samples with ratios of 1:5, 1:10, 1:20, and 1:30 positive to negative clinical samples. (2) Reloading study - Determine diagnostic assay sensitivity in reloading of multiple clinical samples through a Qiagen column in 5x, 10, and 20x sample volumes (1 positive plus 4, 9, and 19 negative samples).

59 BASIC BIOLOGICAL SCIENCES↗

Developing inductively driven diagnostic X-ray sources to enable transformative radiography and diffraction capabilities on Z

Penetrating X-rays are one of the most effective tools for diagnosing high energy density experiments, whether through radiographic imaging or X-ray diffraction. To expand the X-ray diagnostic capabilities at the 26-MA Z Pulsed Power Facility, we have developed a new diagnostic X-ray source called the inductively driven X-pinch (IDXP). This X-ray source is powered by a miniature transmission line that is inductively coupled to fringe magnetic fields in the final power feed. The transmission line redirects a small amount of Zs magnetic energy into a secondary cavity where 150+ kA of current is delivered to a hybrid X-pinch. In this report, we describe the multi-stage development of the IDXP concept through experiments both on Z and in a surrogate setup on the 1 MA Mykonos facility. Initial short-circuit experiments to verify power ow on Z are followed by short-circuit and X-ray source development experiments on Mykonos. The creation of a radiography-quality X-pinch hot spot is verified through a combination of X-ray diode traces, laser shadowgraphy, and source radiography. The success of the IDXP experiments on Mykonos has resulted in the design and fabrication of an IDXP for an upcoming Z experiment that will be the first-ever X-pinch fielded on Z. We have also pursued the development of two additional technologies. First, the extended convolute post (XCP) has been developed as an alternate method for powering diagnostic X-pinches on Z. This concept, which directly couples the current owing in one of the twelve Z convolute posts to an X-pinch, greatly increases the amount of available current relative to an IDXP (900 kA versus 150 kA). Initial short-circuit XCP experiments have demonstrated the efficacy of power ow in this geometry. The second technology pursued here is the inductively driven transmission line (IDTL) current monitor. These low-current IDTLs seek to measure the current in the final power feed with high fidelity. After three generations of development, IDTL current monitors frequently return cleaner current measurements than the standard B-dot sensors that are fielded on Z. This is especially true on high-inductance experiments where the harshest conditions are created in the nal power feed.

46 INSTRUMENTATION RELATED TO NUCLEAR SCIENCE AND ↗

The National Diagnostic Plan(NDP)for HED Science: September 2021

This report documents the National Diagnostic Plan as of September 2021. The major changes in this version compared to the NDP document issued in 2020 are the new schedules and the text for the national transformative diagnostics–section III. The many local diagnostics for our three Inertial Confinement Fusion (ICF) facilities, NIF, Z, and OMEGA, are updated and captured in section V.

70 PLASMA PHYSICS AND FUSION TECHNOLOGY↗

Health Assessment and Performance Monitoring of Large Machine Diagnostics

Presentation to be given at the CCS-6 Statistical Seminar Series. Regularly maintained and operated diagnostic machines are a backbone of data collection and are a vital component of the Stockpile Stewardship Program’s efforts to better understand nuclear physics. The Cygnus X-ray machine, stationed at the Nevada National Security Site’s U1a underground facility, is one such diagnostic that provides a radiographic capability for the subcritical experiment program. Component failures within Cygnus can result in catastrophic downtime for the diagnostic, affecting performance, schedules, and cost. However, over the years various measurements have been collected on the two Cygnus axes, including voltage and current measurements at different locations, which we believe have predictive power to indicate machine health. We will share preliminary insight into this data and the machine learning approaches we are taking to assess Cygnus’ health, observe declining performance, and predict failures.

97 MATHEMATICS AND COMPUTING↗

Feasibility Study: High-k Temperature (HiT) Fluctuation Diagnostic

The objective of the proposed research was to explore the feasibility of making measurements of high-k (electron-scale, ETG-relevant) electron temperature fluctuations in the core plasma of tokamaks and stellarators. We found that soft X-ray imaging combined with our novel pseudolocal tomographic algorithm enables local measurements of low-k (ion-scale, ITG/TEM and KBM/MTM relevant) electron temperature fluctuations in spherical tokamaks. The design parameters needed to consider deploying this new diagnostic are presented, and predictions for what the diagnostic would measure in L-mode and H-mode plasmas at NSTX-U, a high performance spherical tokamak in the USA, suggest that the new diagnostic can be used to study turbulence and transport over a wide range of plasma parameters, such as collisionality and plasma beta.

70 PLASMA PHYSICS AND FUSION TECHNOLOGY↗

The National Diagnostic Plan (NDP) for HED Science September 2022

This documents the National Diagnostic Plan as of September 2022. The major changes in this version compared to the NDP document issued in 2021 are the new schedules and the text for the national transformative diagnostics - section III. The many local diagnostics for our three Inertial Confinement Fusion (ICF) facilities; NIF, Z and OMEGA are updated and captured in section V.

70 PLASMA PHYSICS AND FUSION TECHNOLOGY↗

The National Diagnostic Plan (NDP) for HED Science September 2023

This documents the National Diagnostic Plan as of September 2023. The major changes in this version compared to the NDP document issued in 2021 are the new schedules and the text for the national transformative diagnostics - section III. The many local diagnostics for our three Inertial Confinement Fusion (ICF) facilities; NIF, Z and OMEGA are updated and captured in section V.

70 PLASMA PHYSICS AND FUSION TECHNOLOGY↗

Developing and applying quantifiable metrics for diagnostic and experiment design on Z

This project applies methods in Bayesian inference and modern statistical methods to quantify the value of new experimental data, in the form of new or modified diagnostic configurations and/or experiment designs. We demonstrate experiment design methods that can be used to identify the highest priority diagnostic improvements or experimental data to obtain in order to reduce uncertainties on critical inferred experimental quantities and select the best course of action to distinguish between competing physical models. Bayesian statistics and information theory provide the foundation for developing the necessary metrics, using two high impact experimental platforms on Z as exemplars to develop and illustrate the technique. We emphasize that the general methodology is extensible to new diagnostics (provided synthetic models are available), as well as additional platforms. We also discuss initial scoping of additional applications that began development in the last year of this LDRD.

97 MATHEMATICS AND COMPUTING↗

Millimeter-Wave Imaging Technology Development for Real-Time 2D and 3D Fusion Plasma Diagnostics

Including a one year No-Cost Extension, The University of California, Davis has been funded since 2020 to advance innovative millimeter-wave diagnostics for fusion plasma research. This work includes: (1) Developing and applying cutting-edge System-on-Chip millimeter wave Integrated Circuit (IC) technology for Electron Cyclotron Emission Imaging (ECEI) and Microwave Imaging Reflectometry (MIR) on the DIII-D tokamak and the NSTX-U spherical tokamak. (2) Development of radiation-hardened millimeter-wave chip for diagnostics in harsh environments, utilizing wide bandgap Gallium Nitride (GaN) semiconductors. (3) Integrating forward-modeling synthetic diagnostics to enable advanced, real-time plasma prediction and feedback control. Originally planned as a three-year program (2020–2023), the project was granted a one-year no-cost extension, extending its duration through the end of 2024.

70 PLASMA PHYSICS AND FUSION TECHNOLOGY↗

ORNL Portable Diagnostic Package for Evaluating Mirror Performance

Oak Ridge National Laboratory (ORNL) and Realta Fusion successfully executed a one-year collaborative effort to deploy the Portable Diagnostic Package (PDP) on the Wisconsin HTS Axisymmetric Mirror (WHAM) and to assess future diagnostic needs. The PDP consists of an optical emission spectroscopy (OES) subsystem and a Thomson scattering (TS) subsystem. Within the first two months, the PDP OES subsystem was installed, integrated with WHAM timing, and handed over to trained Realta personnel. It immediately delivered multi-channel impurity surveys and the first spatially resolved plasma-rotation profiles inferred from C III Doppler shifts. The TS subsystem was commissioned within the first six months; transportation of the class IV laser system, approval of the safety plan, and the integration with WHAM timing with 100 ns resolution. The TS subsystem provided the first localized electron temperature measurements in WHAM commissioning shots. Leveraging these results, the team has discussed a diagnostic concept map for Realta’s next-step facility, Anvil, identifying line-of-sight constraints, required temporal resolution, and hardware upgrades.

70 PLASMA PHYSICS AND FUSION TECHNOLOGY↗

Fast ion diagnostics and physics at MAST-Upgrade (Final Report)

The main contribution of UCI personnel to MAST-U was installation of the solid-state neutral particle analyzer (SSNPA) diagnostic, which was documented in a 2022 Review of Scientific Instruments article by UCI PhD student Garrett Prechel. Another paper by PI William Heidbrink et al supplied a helpful tool for analysis of the data from the 3 MeV proton diagnostic [Plasma Phys. Cont. Fusion, 2021]. Useful advice was also given concerning the FIDA diagnostic.

70 PLASMA PHYSICS AND FUSION TECHNOLOGY↗

The National Diagnostic Plan (NDP) for HED Science September 2025

This documents the National Diagnostic Plan as of September 2025. The major changes in this version compared to the NDP document issued in 2024 are the new schedules and the text for the national transformative diagnostics - section III. The many local diagnostics for our three Inertial Confinement Fusion (ICF) facilities; NIF, Z and OMEGA are also updated and captured in section V.

70 PLASMA PHYSICS AND FUSION TECHNOLOGY↗

Completion document for MRT 8824 - Upgrade NIF’s gaseous radiochemistry diagnostics (RAGS) to support weapons science

This milestone highlights the successful upgrade and deployment of the Radiochemical Analysis of Gaseous Samples (RAGS) system, which delivers high-quality measurements (<20% uncertainty) of activated gaseous species from NIF implosions. These measurements are critical for supporting Stockpile Stewardship Program (SSP) relevant platforms, including LANL’s Double Shell and LLNL’s Pushered Single Shell campaigns. The RAGS diagnostic technique enables analysis of short-range mixing in implosions using high-Z shells, which are otherwise inaccessible to conventional x-ray diagnostic methods. By facilitating the investigation of high-Z material mixing into fusion burn, this system provides essential data for quantifying and interpreting results in high-energy density (HED) experiments. This report details the physics motivation, diagnostic fundamentals, planned and enacted upgrade work, and the quantification of uncertainty for the upgraded system.

38 RADIATION CHEMISTRY, RADIOCHEMISTRY, AND NUCLEA↗

Spin Diagnostics Using Mott Polarimeter for the EIC Pre-Injector

Polarization measurement and front-end commissioning are critical steps in the EIC preinjector program. We designed a spin-diagnostics beamline at around 4 MeV for front-end commissioning. This paper describes a high-energy Mott polarimeter, including Mott scattering, the Sherman function, and extrapolation toward single elastic scattering in finite-thickness foils. We summarize the key equations used to calculate essential design parameters, including detection time, effective Sherman function, differential cross section, and Mott polarimeter figure of merit. We also present the diagnostics beamline lattice design and kicker design for continuous spin-polarization monitoring. These notes provide concepts, formulas, and methods for diagnostic-beamline design and commissioning measurements.

43 PARTICLE ACCELERATORS↗

Virtual Diagnostic Suite for Electron Beam Prediction and Control at FACET-II

We discuss the implementation of a suite of virtual diagnostics at the FACET-II facility currently under commissioning at SLAC National Accelerator Laboratory. The diagnostics will be used for the prediction of the longitudinal phase space along the linac, spectral reconstruction of the bunch profile, and non-destructive inference of transverse beam quality (emittance) while using edge radiation at the injector dogleg and bunch compressor locations. These measurements will be folded into adaptive feedbacks and Machine Learning (ML)-based reinforcement learning controls to improve the stability and optimize the performance of the machine for different experimental configurations. In this paper we describe each of these diagnostics with expected measurement results that are based on simulation data and discuss progress towards implementation in regular operations.

Emma, Claudio (ORCID:0000000247191831)↗

Laboratory Calibrations of Fe xii–xiv Line-Intensity Ratios for Electron Density Diagnostics

In this work, we have used an electron beam ion trap to measure electron-density-diagnostic line-intensity ratios for extreme ultraviolet lines from Fe xii, xiii, and xiv at wavelengths of ≈185–205 and 255–276 Å. These ratios can be used as density diagnostics for astrophysical spectra and are especially relevant to solar physics. We found that density diagnostics using the Fe xiii 196.53/202.04 and the Fe xiv 264.79/274.21 and 270.52A/274.21 line ratios are reliable using the atomic data calculated with the Flexible Atomic Code (FAC). On the other hand, we found a large discrepancy between the FAC theory and experiment for the commonly used Fe xii (186.85 + 186.88)/195.12 line ratio. These FAC theory calculations give results similar to the data tabulated in CHIANTI, which are commonly used to analyze solar observations. Our results suggest that the discrepancies seen between solar coronal density measurements using the Fe xii (186.85 + 186.88)/195.12 and Fe xiii 196.54/202.04 line ratios are likely due to issues with the atomic calculations for Fe xii.

74 ATOMIC AND MOLECULAR PHYSICS↗

The Low-redshift Lyman Continuum Survey. II. New Insights into LyC Diagnostics

The Lyman continuum (LyC) cannot be observed at the epoch of reionization (z ≳ 6) owing to intergalactic H I absorption. To identify LyC emitters (LCEs) and infer the fraction of escaping LyC, astronomers have developed various indirect diagnostics of LyC escape. Using measurements of the LyC from the Low-redshift Lyman Continuum Survey (LzLCS), we present the first statistical test of these diagnostics. While optical depth indicators based on Lyα, such as peak velocity separation and equivalent width, perform well, we also find that other diagnostics, such as the [O III ]/[O II ] flux ratio and star formation rate surface density, predict whether a galaxy is an LCE. The relationship between these galaxy properties and the fraction of escaping LyC flux suggests that LyC escape depends strongly on H I column density, ionization parameter, and stellar feedback. We find that LCEs occupy a range of stellar masses, metallicities, star formation histories, and ionization parameters, which may indicate episodic and/or different physical causes of LyC escape.

79 ASTRONOMY AND ASTROPHYSICS↗

Earth System Model Aerosol–Cloud Diagnostics (ESMAC Diags) package, version 2: assessing aerosols, clouds, and aerosol–cloud interactions via field campaign and long-term observations

Abstract. Poor representations of aerosols, clouds, and aerosol–cloud interactions (ACIs) in Earth system models (ESMs) have long been the largest uncertainties in predicting global climate change. Huge efforts have been made to improve the representation of these processes in ESMs, and the key to these efforts is the evaluation of ESM simulations with observations. Most well-established ESM diagnostics packages focus on the climatological features; however, they lack process-level understanding and representations of aerosols, clouds, and ACIs. In this study, we developed the Earth System Model Aerosol–Cloud Diagnostics (ESMAC Diags) package to facilitate the routine evaluation of aerosols, clouds, and ACIs simulated the Energy Exascale Earth System Model (E3SM) from the US Department of Energy (DOE). This paper documents its version 2 functionality (ESMAC Diags v2), which has substantial updates compared with version 1 (Tang et al., 2022a). The simulated aerosol and cloud properties have been extensively compared with in situ and remote-sensing measurements from aircraft, ship, surface, and satellite platforms in ESMAC Diags v2. It currently includes six field campaigns and two permanent sites covering four geographical regions: the eastern North Atlantic, the central US, the northeastern Pacific, and the Southern Ocean. These regions produce frequent liquid- or mixed-phase clouds, with extensive measurements available from the DOE Atmospheric Radiation Measurement user facility and other agencies. ESMAC Diags v2 generates various types of single-variable and multivariable diagnostics, including percentiles, histograms, joint histograms, and heatmaps, to evaluate the model representation of aerosols, clouds, and ACIs. Select examples highlighting the capabilities of ESMAC Diags are shown using E3SM version 2 (E3SMv2). In general, E3SMv2 can reasonably reproduce many observed aerosol and cloud properties, with biases in some variables such as aerosol particle and cloud droplet sizes and number concentrations. The coupling of aerosol and cloud number concentrations may be too strong in E3SMv2, possibly indicating a bias in processes that control aerosol activation. Furthermore, the liquid water path response to a perturbed cloud droplet number concentration behaves differently in E3SMv2 and observations, which warrants further study to improve the cloud microphysics parameterizations in E3SMv2.

54 ENVIRONMENTAL SCIENCES↗