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At least 145 records · Page 8

How Can Probabilistic Solar Power Forecasts Be Used to Lower Costs and Improve Reliability in Power Spot Markets? A Review and Application to Flexiramp Requirements

Net load uncertainty in electricity spot markets is rapidly growing. There are five general approaches by which system operators and market participants can use probabilistic forecasts of wind, solar, and load to help manage this uncertainty. These include operator situation awareness, resource risk hedging, reserves procurement, definition of contingencies, and explicit stochastic optimization. We review these approaches, and then provide a case study in which a method for using probabilistic solar forecasts to define needs for reserves is developed and evaluated. The case study has three parts. First, we describe building blocks for enhancing the Watt-Sun solar forecasting system to produce probabilistic irradiance and power forecasts. Second, relationships between Watt-Sun forecasts for multiple sites in California and the system's need for flexible ramp capability (flexiramp) are defined by machine learning and statistical methods. Third, the performance of present methods to defining flexiramp requirements, which are not conditioned on weather and renewables forecasts, is compared with that of probabilistic solar forecast-based requirements, using a multi-timescale production costing model with an 1820-bus representation of the WECC power system. Significant potential savings in fuel and flexiramp procurement costs from using solar-informed reserve requirements are found.

14 SOLAR ENERGY↗

Geothermal Operational Optimization with Machine Learning

The Geothermal Operational Optimization with Machine Learning (GOOML) project has developed a generic and extensible component-based system modeling framework to study complex geothermal fields using a data-driven approach. Through building a digital twin of a geothermal steam field with the GOOML modeling framework, operators can analyze historical and forecasted power production, explore possible steam field configurations, and optimize real world operations, all in a cost-effective digital environment. The GOOML modeling software is based on a historical data-assimilation framework that uses first-principal thermodynamics to model steam field components using historical data, and a forecast framework that uses machine-learning-driven models of steam field components to predict future operations. This modeling framework creates countless new opportunities for digital exploration of steam field design and operations. To date, digital twins have been developed for several steam fields in New Zealand and the United States. These digital twins have been validated by comparing hindcast predictions against historical production data. Field design and operations have been explored using genetic optimization and reinforcement learning. Initial results show compelling and often surprising opportunities for improved design and operation of fields with 2 to 5 percent improvements in annual energy production. GOOML is driving a step-change in geothermal operations by applying state-of-the-art machine learning algorithms, comprehensive data analytics, and a first-of-its-kind intelligent geothermal systems model.

40 EE - Geothermal Technologies Office (EE-4G)↗

Charging infrastructure access and operation to reduce the grid impacts of deep electric vehicle adoption

Electric vehicles will contribute to emissions reductions in the United States, but their charging may challenge electricity grid operations. We present a data-driven, realistic model of charging demand that captures the diverse charging behaviours of future adopters in the US Western Interconnection. We study charging control and infrastructure build-out as critical factors shaping charging load and evaluate grid impact under rapid electric vehicle adoption with a detailed economic dispatch model of 2035 generation. We find that peak net electricity demand increases by up to 25% with forecast adoption and by 50% in a stress test with full electrification. Locally optimized controls and high home charging can strain the grid. Shifting instead to uncontrolled, daytime charging can reduce storage requirements, excess non-fossil fuel generation, ramping and emissions. Our results urge policymakers to reflect generation-level impacts in utility rates and deploy charging infrastructure that promotes a shift from home to daytime charging.

33 ADVANCED PROPULSION SYSTEMS↗

Reimagining How Flood Warnings Can Inform Decision‐Making and Community Actions

Society faces increasingly severe flood hazards, intensifying demand for flood early warning systems (FEWS) that deliver accurate and actionable information. However, most existing FEWS remain prediction‐centric, treating decision‐making as a downstream consumer of hazard forecasts while offering limited support for uncertainty interpretation, risk communication, and real‐world response. This Perspective presents a vision and blueprint for a novel inland FEWS‐decision‐making (FEWS‐DM) framework that repositions decision‐making as an equal partner in the forecasting process—not a passive recipient of its outputs. The framework is built on three tightly coupled, co‐evolving thrusts: Physical Science (T1), which advances flood prediction with quantified uncertainty informed by decision relevance; Human Science (T2), which incorporates psychology, behavior, and cultural and institutional context; and Decision Science (T3), which unifies physical predictions and human factors through principled, utility‐based decision support with end‐to‐end uncertainty management. Rather than treating T1 as a solved problem, FEWS‐DM recognizes that forecast development itself must be shaped by decision needs through continuous bidirectional feedback. We identify key scientific, behavioral, and operational challenges limiting such integration and discuss the enabling role of AI, while emphasizing human‐centered design and community feedback as essential for building trust and improving flood risk management.

54 ENVIRONMENTAL SCIENCES↗

Technology Integration to Gain Commercial Efficiency for the Urban Goods Delivery System, Meet Future Demand for City Passenger and Delivery Load/Unload Spaces, and Reduce Energy Consumption

This three-year project supported by the U.S. Department of Energy Vehicle Technologies Office has the potential to radically improve the urban freight system in ways that help both the public and private sectors. Working from 2018-2021, project researchers at the University of Washington’s Urban Freight Lab and collaborators at the Pacific Northwest National Laboratory have produced key data, tested technologies in complex urban settings, developed a prototype parking availability app, and helped close major knowledge gaps. All the fruits of this project can be harnessed to help cities better understand, support and actively manage truck load/unload operations and their urban freight transport infrastructure. Project learnings and tools can be used to help make goods delivery firms more efficient by reducing miles traveled and the time it takes to complete deliveries, benefitting businesses and residents who rely on the urban freight system for supplies of goods. And, ultimately, these project learnings and tools can be used to make cities more livable by minimizing wasted travel, which, in turn, contributes to reductions in fuel consumption and emissions. Cities today are challenged to effectively and efficiently manage their infrastructure to absorb the impacts of ever-increasing e-commerce-fueled delivery demand. All delivery trucks need to park somewhere to unload and load. Yet today’s delivery drivers have no visibility on available parking until they arrive at a site, which may be full. That means they can wind up cruising for parking, which wastes time and fuel and contributes to congestion. Once drivers do find parking, the faster they can unload at the spot, the faster they free up space for other drivers, helping others avoid circling for parking. This makes the parking space—and thus the greater load/unload network—more productive. To this end, the research team successfully met the project’s three goals, developing and piloting strategies and technologies to: 1. Reduce parking-seeking behavior in the study area by 20%; 2. Reduce parcel truck dwell time (the time a truck spends in a spot to load/unload) in the study area by 30%; 3. Increase curb space, alley space and private loading bay occupancy rates in the study area. The research team met these goals by creating and piloting on Seattle streets OpenPark, a first-of-its-kind real-time and forecasting curb parking app customized for commercial delivery drivers—giving drivers the “missing link” in their commonly used routing tools that tell them how best to get to delivery locations, but not what parking is available to use when they get there. Installing in-ground sensors on commercial vehicle load zones (CVLZs) and passenger load zones (PLZs) in the 10-block study area in Seattle’s downtown neighbourhood of Belltown let researchers glean real-time curb parking data. The research team also met project goals by piloting three parcel lockers in public and private spaces open to any delivery carrier, creating a consolidated delivery hub that lets drivers complete deliveries faster and spend less time parked. Researchers collected and analysed data to produce the first empirical, robust, statistically significant results as to the impact of the lockers, and app, on on-the-ground operations. In addition to collecting and analyzing sensor and other real-time and historical data, researchers rode along with delivery drivers to confirm real-world routing and parking behavior. Researchers also surveyed building managers on their private loading bay operations to understand how to boost usage.

97 MATHEMATICS AND COMPUTING↗

Deep learning-accelerated 3D carbon storage reservoir pressure forecasting based on data assimilation using surface displacement from InSAR

Fast forecasting of the reservoir pressure distribution during geologic carbon storage (GCS) by assimilating monitoring data is a challenging problem. Due to high drilling cost, GCS projects usually have spatially sparse measurements from few wells, leading to high uncertainties in reservoir pressure prediction. To address this challenge, we use low-cost Interferometric Synthetic-Aperture Radar (InSAR) data as monitoring data to infer reservoir pressure build up. We develop a deep learning-accelerated workflow to assimilate surface displacement maps interpreted from InSAR and to forecast dynamic reservoir pressure. Employing an Ensemble Smoother Multiple Data Assimilation (ES-MDA) framework, the workflow updates three-dimensional (3D) geologic properties and predicts reservoir pressure with quantified uncertainties. We use a synthetic commercial-scale GCS model with bimodally distributed permeability and porosity to demonstrate the efficacy of the workflow. A two-step CNN-PCA approach is employed to parameterize the bimodal fields. The computational efficiency of the workflow is boosted by two residual U-Net based surrogate models for surface displacement and reservoir pressure predictions, respectively. The workflow can complete data assimilation and reservoir pressure forecasting in half an hour on a personal computer.

25 ENERGY STORAGE↗

Community Engagement - A Citizen-Centric Approach to Seeking a Social License - 20017

The long regulatory road has finally been completed-after years of effort a Record of Decision has been signed and a Permit to Construct has been granted or a Permit to Operate has been obtained. But what about the other road that should be taken in parallel-community engagement? Working with the public is not a sequential activity, rather it is a consequential one and needs to be integrated with overall project planning. Unless you have effectively, meaningfully, and patiently engaged with the project's communities of impact, you may find your project trying to obtain a social license or a social license to operate (SLO). The SLO has its origins in the mining industry and its roots in the business model of corporate social responsibility and sustainability. These latter practices are well known to the US DOE and its contractor community. Aspects of the SLO are emerging as individuals and communities are becoming more informed and have increased expectations for being able to influence and shape decisions. When local community issues are not sought out, listened to, or addressed early, and questions are left unanswered, they can become agenda items for larger unaffiliated groups, and project loss (through delays and/or cancellation) can occur. Issues can transition from resolvable to intractable, a type of SLO face-off. Social media campaigns, serial negative media coverage, and protest signs at project sites opposing regulatory decisions already made are no longer anomalies. These types of incidents demonstrate the increasingly delicate relationship between approved regulatory/technical decisions and public acceptance of those decisions. A SLO is not a requirement. However, the building-blocks of a SLO - working with members of affected communities to build understanding, potentially to obtain and maintain community acceptance or even gain approval or support - are evidence of leadership by project sponsors. Actions taken, or not taken, by project sponsors truly have the ability to influence an outcome. While projects are not assured of success or failure, engaging the community in an empowered process is an investment of time and resources toward success for the project and thus for the communities of impact. Authors Note: Extensive literature searches were performed in developing this paper. The majority of the published literature on SLO as a 'movement' was found from sources in Canada, the European Union (Germany and France in particular), South Asia, South Korea, and many Latin American countries. The literature addressed resource development (mining), infrastructure, and energy projects. Articles written by US sources often spoke to origins and structural theory, specific project issues such as Not in My Back Yard (NIMBY) and to protests/demonstrations related to those projects, rather than systemic opposition/conflict phenomena. For these reasons many international SLO experiences and sources are cited in the discussion. The authors recognize these non-US experiences with SLO as having a 'forecast' value to US projects, especially those related to nuclear projects of any type, waste treatment and disposal, energy development (especially fossil fuels as well as alternative sources), mining, and infrastructure. The body of future SLO experiences in the US will shape the future responses to it. (authors)

99 GENERAL AND MISCELLANEOUS↗

City-Wide Distributed Roof-Top Photovoltaic System Adoption Forecast, Grid Impact Simulation, & Neighborhood Microgrid Contribution Assessment

The adoption of distributed photovoltaic (PV) systems grew significantly in recent years. Market projections anticipate future growth for both residential and commercial installations. To understand grid impacts associated with distributed PV, useful hosting capacity studies require accurate representations of the spatial distribution of PV adoptions. Prediction of PV locations and numbers depends on median income data, building use zoning maps, and permit records to understand existing trends and predict future adoption rates and locations throughout an entire city. Using the PV adoption data, advanced and realistic simulations were performed to capture the distributed PV impacts on the grid. Also, using graph theory community detection hundreds of neighborhood microgrids can be discovered for the entire city by identifying densely connected loads that are sparsely connected to other communities. Then, based on the PV adoption predictions, this work identified the contribution of PV within each of the newly discovered graph theory defined microgrid communities.

24 POWER TRANSMISSION AND DISTRIBUTION↗

Electricity Produced from Photovoltaic Systems in Apartment Buildings and Self-Consumption: Comparison of the Situation in Various IEA PVPS Countries

Over the last two decades, grid-connected solar photovoltaic systems have increased from a niche market to one of the leading power generation capacity additions annually. In 2018 the total installed photovoltaic electricity generation capacity exceeded 500 GW. Another doubling is forecasted until the early 2020s. Therefore, the further development is coupled with the question at what prices solar photovoltaic electricity can be provided and delivered to the customers. The installation of PV systems for self-consumption is already now an interesting option for many people but in general limited to those who have access to a rooftop they own or can use. A new envelopment to enable residents of multi apartment buildings to commonly use electricity generated by a PV system (collective self-consumption) is a relatively new development and is still facing a lot of administrative and regulatory challenges.

29 ENERGY PLANNING, POLICY, AND ECONOMY↗

Examples of State and Utility Actions on Proactive Planning and Investments

As states across the U.S. confront rising electricity demand, clean energy deployment, grid modernization imperatives, and the integration of large new loads, some regulators and utilities are shifting away from reactive, “just-in-time” investment approaches toward more proactive planning and investment frameworks. This report compiles examples of jurisdictional and utility actions that reshape planning processes, cost recovery mechanisms, and performance oversight to anticipate—rather than simply respond to—future grid needs. Several themes emerge from state actions examined in this report. First, legislatures and commissions are increasingly directing utilities to proactively upgrade their distribution and transmission systems, reflecting a shift toward a forward-looking system that aligns planning with state policy goals. Second, states are establishing long-term, iterative planning frameworks that often feature multi-year horizons, biannual or annual compliance reporting, structured opportunities for stakeholder engagement, and emphasis on collaboration among utilities, regulators, and stakeholders. Third, states are actively investigating innovative cost recovery mechanisms designed to support accelerated electrification and grid modernization, while balancing consumer advocates’ concerns regarding the ratepayer financial risks of premature investments. Fourth, performance metrics and reporting requirements are being developed to ensure transparency and accountability for proactive investments. Fifth, methodological improvements in planning—such as aligning load forecasting assumptions, incorporating sensitivities, and considering load management potential across building, vehicles, storage, and demand response—are recurring areas of stakeholder focus across jurisdictions. Overall, these developments signify a growing recognition among state regulators, utilities, and stakeholders that proactive planning—supported by clear definitions, consistent and transparent methodologies, robust performance metrics, and innovative cost recovery mechanisms—is a tool that can be used to address the scale and urgency of contemporary grid needs.

electricity market↗

Integrated Distribution Planning

The contemporary distribution planning landscape is comprised of an increasing number of factors that require integration into the engineering of the modern electric grid. Expectations for electric utilities to accommodate heightened awareness of stakeholders' interest in things like decarbonization, resilience and equity are growing. As these interests are formed into objectives, many jurisdictions will experience increasing levels of load modifying technologies like DER, building and industrial electrification and electric vehicles which prove not only to challenge the capabilities of the grid; but the processes by which planning for it is traditionally done. Other related factors that strain the conventional distribution planning mold are the swelling amount and sources of data associated with these technologies and the need it creates for improved capabilities in the processes and tools that manage it. As the complexity of the distribution system expands, so will the distribution system's effects on the transmission and generation systems that it is a part of. Forecasting distribution system load and DER are examples of areas where this complexity will manifest, and harmonizing distribution forecasting with transmission and generation forecasting requires higher amounts of intentionality as these typically separate processes become a solitary one. Of course, core activities do not cease as a utility begins to integrate these other factors, and in this webinar we explore specifics of how distribution planning can be expected to evolve as progress towards Integrated Distribution System Planning is made.

24 POWER TRANSMISSION AND DISTRIBUTION↗

Planning Roadmap for DER Integration in India: Industry Best Practices and Resource Guide

Ensuring safe, reliable, cost-effective DER integration at scale requires holistic planning, broad stakeholder engagement, and should address key development areas such as standards adoption, equipment testing and certification, interoperability and cybersecurity, interconnection procedures, and advanced forecasting and DER management. Each of these areas currently represent significant challenges for utilities, regulators, OEMs, developers, and even consumers worldwide. India has already seen significant growth of DERs and has announced targets for substantial growth yet to come, with the potential for DERs to make up a non-negligible portion of the country's overall generation capacity. As such, it is of critical importance that Indian stakeholders consider the potential impacts of wide-spread adoption of DERs and take preemptive action related to the five development areas listed here, among others. India should consider strategies including the adoption of key DER standards related to interconnection, testing, and cybersecurity; enabling effective and secure communication channels for DER interoperability; testing and certifying DER equipment in accredited testing laboratories; building robust, streamlined interconnection procedures; and revamping legacy system planning structures to incorporate DERs in a holistic planning framework.

24 POWER TRANSMISSION AND DISTRIBUTION↗

Momentum power spectrum of SDSS galaxies by massE cosmic ruler: 2.1×improvement in measure of growth rate

ABSTRACT Peculiar motion of galaxies probes the structure growth in the universe. In this study, we employ the galaxy stellar mass-binding energy (massE) relation with only two nuisance parameters to build the largest peculiar-velocity (PV) catalogue to date, consisting of 229 890 ellipticals from the main galaxy sample (MGS) of the Sloan Digital Sky Survey (SDSS). We quantify the distribution of the massE-based distances in individual narrow redshift bins (dz = 0.005), and then estimate the PV of each galaxy based on its offset from the Gaussian mean of the distribution. As demonstrated with the Uchuu-SDSS mock data, the derived PV and momentum power spectra are insensitive to accurate calibration of the massE relation itself, enabling measurements out to a redshift of 0.2, well beyond the current limit of z = 0.1 using other galaxy scaling laws. We then measure the momentum power spectrum and demonstrate that it remains almost unchanged if varying significantly the redshift bin size within which the distance is measured, as well as the intercept and slope of the massE relation, respectively. By fitting the spectra using the perturbation theory model with four free parameters, fσ8 is constrained to fσ8 = 0.459$^{+0.068}_{-0.069}$ over Δz = 0.02–0.2, 0.416$^{+0.074}_{-0.076}$ over Δz = 0.02–0.1, and 0.526$^{+0.133}_{-0.148}$ over Δz = 0.1–0.2. The error of fσ8 is 2.1 times smaller than that by the redshift space distortion (RSD) of the same sample. A Fisher matrix forecast illustrates that the constraint on fσ8 from the massE-based PV can potentially exceed that from the stage-IV RSD in late universe (z<0.5).

Shi, Yong (ORCID:0000000286146275)↗

Learning-based CO 2 concentration prediction: Application to indoor air quality control using demand-controlled ventilation

There have been increasing concerns over the air quality inside buildings as high levels of bio-effluents can cause nausea, dizziness, headaches, and fatigue to the people working in those spaces. First published in 2004 as Standard 62.1, ASHRAE Standard 62.2-2019 requires highly occupied spaces to implement heating, ventilation, and air conditioning (HVAC) that can dilute contaminants produced by occupants. In this regard, occupant-centric ventilation control has been regarded as an effective practice to maintain a satisfactory indoor air quality (IAQ) when dealing with highly variable occupancy environments. However, few established models in current literature and practice consider dynamic occupancy behavior and adaptive IAQ control. To address this gap, a dynamic indoor CO2 model is constructed using machine learning algorithms to forecast CO2concentrations across a range of forecasting horizons. Herein, we tuned and compared six state-of-the-algorithms—including Support Vector Machine, Ada Boost, Random Forest, Gradient Boosting, Logistic Regression, and Multilayer Perceptron. The algorithms’ performances are validated using CO 2 and historical meteorological data collected from a campus classroom with a variable occupancy rate. Simulation results showed that Multilayer Perceptron can strongly predict the volatile CO 2 behavior and also outperforms other algorithms in terms of accuracy. Furthermore, a control strategy capable of modeling and detecting dynamic patterns of CO 2 level is utilized to modulate the ventilation rate in real-time and also reduce the energy consumption. The proposed controller reduced the HVAC fan’s energy consumption by 51.4% and provide ventilation as needed per the ASHRAE standards.

32 ENERGY CONSERVATION, CONSUMPTION, AND UTILIZATI↗

Probabilistic Forecast of All-Sky Solar Radiation Using Enhanced WRF-Solar: Preprint

This study presents enhancements of the Weather Research and Forecasting model with solar extensions (WRF-Solar) to provide probabilistic forecasts of solar radiation. Our approach builds ensemble WRF-Solar runs by introducing stochastic perturbations of variables that produce the largest uncertainties in predicting surface irradiance and clouds. The key variables are identified using tangent linear sensitivity analysis of six physics packages responsible for all-sky irradiance variability. An optimal strategy to stochastically perturb the selected variables is developed and applied to WRF-Solar to generate ensemble members for day-ahead solar prediction. The National Solar Radiation Database (NSRDB) is used to validate the ensemble forecast at arbitrary locations on the model grid. Preliminary results indicate that the proposed technique can potentially produce WRF-Solar ensembles providing reliable information of solar prediction uncertainty. This study describes the implemented methodology and initial results as well as future research to improve ensemble-based probabilistic forecasts with WRF-Solar.

all-sky↗

High-Resolution South American Wind Resource Data Downscaled with Generative Machine Learning Conditioned on Near-Surface Observations

High-resolution historical wind data was developed for the entirety of South America using the innovative Super-Resolution for Renewable Resource Data (sup3r) machine learning framework. The publicly available Sup3rWind South America dataset represents a significant advancement in wind resource data generation, leveraging generative machine learning conditioned on near-surface observations from the Meteorological Assimilation Data Ingest System (MADIS) to efficiently and accurately downscale coarse reanalysis data from the European Centre for Medium-Range Weather Forecasts (ERA5). This approach produces fine-scale, spatially and temporally coherent wind and meteorological fields hundreds of times more computationally efficient than traditional numerical weather modeling methods, enabling access to high-fidelity wind information across both continental and offshore regions. Sup3rWind South America builds on the earlier Sup3rWind Ukraine dataset through improvements in model architecture and outputs conditioned on near-surface observation inputs. As with the Ukraine data release, this dataset includes wind speed, wind direction, temperature, relative humidity, and pressure at a horizontal resolution of ~2 km, representing a 15x spatial enhancement relative to the 31 km ERA5 grid. Wind speed and direction are provided at 5-minute resolution, a 12x temporal refinement compared to the hourly ERA5 data, while temperature, relative humidity, and pressure remain at hourly resolution. The data covers all years from 2005 to 2024. Before downscaling, ERA5 inputs were bias-corrected using long-term monthly means and a limited number of quality-controlled observations to align large-scale statistics with regional conditions. The resulting dataset is the first publicly available high-resolution timeseries wind record that provides full spatial coverage of South America. Model validation demonstrates strong agreement with observations across several statistical metrics, consistent with other state-of-the-art high-resolution wind resource datasets. The potential applications of Sup3rWind South America span renewable energy resource assessment, energy system modeling, and grid resilience analysis. The 20-year record and high spatial and temporal resolution support accurate estimation of long-term energy yield and the economic feasibility of potential wind development sites. Continuous coverage across both continental and offshore regions enables comprehensive site prospecting within exclusive economic zones. The 2 km, 5-minute resolution data provide the spatial and temporal variability required for power system simulation, operational planning, and regional risk assessments.

17 WIND ENERGY↗

The Hidden Flexibility of the Natural Gas Network for Electric Power Operations: A Case Study of a Near-Miss Winter Event

The U.S. power sector has become increasingly reliant on gas pipeline networks to deliver fuel to natural gas power plants. In addition to supplying relatively low-cost fuel, gas networks offer generators flexibility in their operations through the ability to deliver fuel when needed by using gas storage facilities or linepack if the gas network is at an operating point below its design capacity. However, disruptions or stress events on the gas network - like those occurring in the Northeast and Texas in recent years - can result in limitations on gas availability to generators at times when generation is in short supply. Here we examine a period of stress that occurred in the winter of 2022 in the Western United States. Using data on the region's natural gas pipeline network and electric generators, we build an integrated gas and electric model that closely replicates the actual dispatch of the period. We then evaluate the implications of removing flexibility employed by the gas network operator, which during that period curtailed scheduled gas deliveries to other parties to increase deliveries to natural gas power plants, which requested more gas than initially forecasted. We find that without the flexibility supplied by the gas network operator, there would have been curtailment of gas generation due to gas offtake constraints, requiring the power system operator to redispatch relying on more expensive generation or to potentially shed load. A sensitivity exploring a wind drought further exacerbates the strain, illustrating the potential challenge of managing gas and grid interactions as systems move to higher shares of variable renewable electricity. Based on this example, we discuss potential coordination strategies between the two system operators to ensure that the power system can successfully utilize and rely on the flexibility offered by natural gas networks.

03 NATURAL GAS↗

National Virtual Biotechnology Laboratory: Report on Rapid R&D Solutions to the COVID-19 Crisis

With funding from the CARES Act, the U.S Department of Energy (DOE) established the National Virtual Biotechnology Laboratory (NVBL) in March 2020 to address key challenges associated with the COVID-19 crisis. NVBL brought together the broad scientific and technical expertise and resources of DOE’s 17 national laboratories to help tackle medical supply short ages, discover potential drugs to fight the virus, develop and validate COVID-19 testing methods, model disease spread and impact across the nation, and understand virus transport in buildings and the environment. National laboratory resources leveraged for this effort include a suite of world-leading user facilities broadly available to the research community, such as light and neutron sources, nanoscale science research centers, sequencing and biocharacterization facilities, and high-performance computing facilities. Within months, NVBL teams produced innovations in materials and advanced manufacturing that mitigated shortages in test kits and personal protective equipment (PPE), creating nearly 1,000 new jobs. They used DOE’s high-performance computers and light and neutron sources to identify promising candidates for antibodies and antivirals that universities and drug companies are now evaluating. NVBL researchers also developed new diagnostic targets and sample collection approaches, and supported U.S. Food and Drug Administration (FDA), Centers for Disease Control and Prevention (CDC), and U.S. Department of Defense (DoD) efforts to establish national guidelines used in administering millions of tests. Researchers used artificial intelligence and high-performance computing to produce near-real-time data analysis to forecast disease transmission, stress on public health infrastructure, and economic impact, which supported decision-makers at the local, state, and national levels. NVBL teams also studied how to control indoor virus movement to minimize uptake and protect human health. NVBL’s accomplishments demonstrate not only the powerful resource represented by DOE’s national laboratories working together to meet national needs, but also the effectiveness of the integrated NVBL framework for rapidly responding to emergencies with research and development (R&D) solutions. As the fight against COVID continues, sustained efforts are needed to confront this pandemic as well as future threats. Examples include: 1) Establishing “supply chains on demand” to meet emergency production needs by leveraging the materials and manufacturing expertise of DOE national laboratories and developing advances in electronics, sensing, robotics, and automation capabilities; 2) Improving the speed and robustness of drug discovery by integrating experimental platforms with DOE’s computational and experimental user facilities, which provide unique resources to support the discovery of high-potential therapeutic agents; 3) Protecting public, environmental, and animal health by developing new testing protocols and instrumentation adaptable to diverse sample types (both physiological and environmental) to quickly detect a wide range of pathogens and monitor other biorisks; 4) Supporting near-real-time data needs of decision-makers at the local, regional, state, and national levels by advancing data curation, analysis, and modeling using artificial intelligence and new data science tools for managing and evaluating large diverse datasets; 5) Harnessing DOE’s expertise in environmental modeling to design rooms and air handling for offices, classrooms, restaurants, and other structures to minimize biorisk transmissions. Going forward, NVBL is poised to apply the unique capabilities and expertise of the national laboratory complex to future national and international emergencies, both natural and engineered. Through this framework, the Office of Science will continue to be an integral component of agency wide efforts to prepare for and respond to biorisks and other crises.

42 ENGINEERING↗