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Results for “UREA”
Search indexed NASA NTRS and DOE OSTI research on propulsion, heat transfer, battery materials and energy systems. Follow report and document links to the original sources.
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Urea-based hydrothermal synthesis of LiNi0.5Co0.2Mn0.3O2 cathode material for Li-ion battery
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Replication Bypass of the N -(2-Deoxy- d -erythro-pentofuranosyl)-urea DNA Lesion by Human DNA Polymerase η
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Urea-Based Macrocycle Selective for Sulfate and Structurally Sensitive to Water
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Effect of Synthesis Temperature on Transient Photoconductivity of g-C 3 N 4 from Urea
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Discovery of 1-(3,3-Dimethylbutyl)-3-(2-fluoro-4-methyl-5-(7-methyl-2-(methylamino)pyrido[2,3- d ]pyrimidin-6-yl)phenyl)urea (LY3009120) as a Pan-RAF Inhibitor with Minimal Paradoxical Activation and Activity against BRAF or RAS Mutant Tumor Cells
The RAS-RAF-MEK-MAPK cascade is an essential signaling pathway, with activation typically mediated through cell surface receptors. The kinase inhibitors vemurafenib and dabrafenib, which target oncogenic BRAF V600E, have demonstrated significant clinical efficacy in melanoma patients harboring this mutation. Because of paradoxical pathway activation, both agents were demonstrated to promote growth and metastasis of tumor cells with RAS mutations in preclinical models and are contraindicated for treatment of cancer patients with BRAF WT background, including patients with KRAS or NRAS mutations. In order to eliminate the issues associated with paradoxical MAPK pathway activation and to provide therapeutic benefit to patients with RAS mutant cancers, we sought to identify a compound not only active against BRAF V600E but also wild type BRAF and CRAF. On the basis of its superior in vitro and in vivo profile, compound 13 was selected for further development and is currently being evaluated in phase I clinical studies.
A Transferable Polarizable Force Field for Urea Crystals and Aqueous Solutions
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Nonlinear Mechano-Optical Behavior and Strain-Induced Structural Changes of l-Valine-Based Poly(ester urea)s
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Scaffold Morphing Identifies 3-Pyridyl Azetidine Ureas as Inhibitors of Nicotinamide Phosphoribosylt
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Dihydrogen Phosphate Clusters: Trapping H2PO4 Tetramers and Hexamers in Urea-Functionalized Molecular Crystals
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Structure of the proton-gated urea channel from the gastric pathogen Helicobacter pylori
Abstract not provided
Selective electrocatalytic synthesis of urea with nitrate and carbon dioxide
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Urea-glass preparation of titanium niobium nitrides and subsequent oxidation to photoactive titanium niobium oxynitrides
Titanium niobium oxynitrides (TiNbON) are an attractive category of potential photocatalysts, but strategies for preparing them remain limited.
Two-Step Synthesis of Poly (urea formaldehyde) Microcapsules
Self-healing coatings have potential to reduce waste and minimize repair costs in industries where materials need to be protected from harsh environmental conditions and mechanical abrasion. These coatings can be created by embedding healing-agent filled microcapsules which release their contents and fill voids in the event of damage. To synthesize microcapsules that are ideal for self-healing coatings, they must have a diameter less than 100 microns, smooth surface morphology, and have improved dispersibility. Our current one-step method does not produce microcapsules within the desired size distribution, so a two-step route where oligomers of the shell wall material are formed prior to microcapsule formation was investigated. This was done by evaluating the effects of solution viscosity, size of reaction vessel, addition of poly (vinyl alcohol) (PVA), and core/shell ratio on microcapsule properties. Characterization of microcapsule size, morphology, and composition was done using optical microscopy, Fourier-transform infrared spectroscopy (FTIR), and thermogravimetric analysis (TGA). Microcapsules with an average diameter of 78 ± 16 microns were successfully synthesized. Further work must be done to minimize PUF crystallites on the surface of the microcapsules.
Ammonium and Urea Transporter Inventory of the Selaginella and Physcomitrella Genomes
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Membrane has high urea-rejection properties
Membranes are synthesized from ethylene and nitrogen in RF plasma at low power, gas-flow rates, and pressure. Ethylene and nitrogen are used because flow rate and partial pressure of each gas can be independently controlled to produce optimum conditions for synthesizing membrane. Membrane is particularly useful in recycling and purifying water.