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Search indexed NASA NTRS and DOE OSTI research on propulsion, heat transfer, battery materials and energy systems. Follow report and document links to the original sources.

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At least 145 records · Page 8
All sourcesNASA NTRSDOE OSTI
DOE OSTI2014

Systems biology perspectives on the carcinogenic potential of radiation

This review focuses on recent experimental and modeling studies that attempt to define the physiological context in which high linear energy transfer (LET) radiation increases epithelial cancer risk and the efficiency with which it does so. Radiation carcinogenesis is a two-compartment problem: ionizing radiation can alter genomic sequence as a result of damage due to targeted effects (TE) from the interaction of energy and DNA; it can also alter phenotype and multicellular interactions that contribute to cancer by poorly understood nontargeted effects (NTE). Rather than being secondary to DNA damage and mutations that can initiate cancer, radiation NTE create the critical context in which to promote cancer. Systems biology modeling using comprehensive experimental data that integrates different levels of biological organization and time-scales is a means of identifying the key processes underlying the carcinogenic potential of high-LET radiation. We hypothesize that inflammation is a key process, and thus cancer susceptibility will depend on specific genetic predisposition to the type and duration of this response. Systems genetics using novel mouse models can be used to identify such determinants of susceptibility to cancer in radiation sensitive tissues following high-LET radiation. Improved understanding of radiation carcinogenesis achieved by defining the relative contribution of NTE carcinogenic effects and identifying the genetic determinants of the high-LET cancer susceptibility will help reduce uncertainties in radiation risk assessment.

59 BASIC BIOLOGICAL SCIENCES↗
DOE OSTI2025

GMFOLD: Subgraph matching for high-throughput DNA-aptamer secondary structure classification and machine learning interpretability

Aptamers are oligonucleotide receptors that bind to their targets with high affinity. Here, we consider aptamers comprised of single-stranded DNA that undergo target-binding-induced conformational changes, giving rise to unique secondary and tertiary structures. Given a specific aptamer primary sequence, there are well-established computational tools (notably mfold) to predict the secondary structure via free energy minimization algorithms. While mfold generates secondary structures for individual sequences, there is a need for a high-throughput process whereby thousands of DNA structures can be predicted in real-time for use in an interactive setting, when combined with aptamer selections that generate candidate pools that are too large to be experimentally interrogated. We developed a new Python code for high-throughput aptamer secondary structure determination (GMfold). GMfold uses subgraph matching methods to group aptamer candidates by secondary structure similarities. We also improve an open-source code, SeqFold, to incorporate subgraph matching concepts. We represent each secondary structure as a lowest-energy bipartite subgraph matching of the DNA graph to itself. These new tools enable thousands of DNA sequences to be compared based on their secondary structures, using machine-learning algorithms. This process is advantageous when analyzing sequences that arise from aptamer selections via systematic evolution of ligands by exponential enrichment (SELEX). This work is a building block for future machine-learning-informed DNA-aptamer selection processes to identify aptamers with improved target affinity and selectivity and advance aptamer biosensors and therapeutics.

Aptamer↗
DOE OSTI2016

Isospin effects in N ≈ Z nuclei in extended density functional theory

This paper overviews various phenomena related to the concept of isospin symmetry. The focus is on N ≈ Z nuclei, which are excellent laboratories of isospin physics. The theoretical framework applied is nuclear density functional theory and its isospin- and angular-momentum projected extensions, as well as symmetry-projected multi-reference models. The topics covered include: isospin impurities, superallowed beta decays, beta-transitions in mirror nuclei, isospin breaking hadronic interactions, mirror and triplet binding energy differences, and isoscalar pairing.

Physics↗
DOE OSTI2014

Sci—Fri PM: Topics — 01: A monte carlo model of a miniature low-energy x-ray tube using EGSnrc

The INTRABEAM system (Carl Zeiss, Oberkochen, Germany) is a miniature x-ray generator for use in intraoperative radiotherapy and brachytherapy. The device accelerates electrons to up to 50 keV, which are then steered down an evacuated needle probe to strike a thin gold target. For accurate dosimetry of the INTRABEAM system, it is important that the photon spectrum be well understood. Measurements based on air-kerma are heavily impacted by photon spectra, particularly for low photon energies due to the large photoelectric contribution in air mass energy absorption coefficient. While low energy photons have little clinical significance at treatment depths, they may have a large effect on air-kerma measurements. In this work, we have developed an EGSnrc-based monte carlo (MC) model of the Zeiss INTRABEAM system to study the source photon spectra and half-value layers (HVLs) of the bare probe and with various spherical applicators. HVLs were calculated using the analytical attenuation of air-kerma spectra. The calculated bare probe spectrum was compared with simulated and measured results taken from literature. Differences in the L-line energies of gold were found between the spectra predicted by EGSnrc and Geant4. This is due to M and N shell averaging during atomic transitions in EGSnrc. The calculated HVLs of the bare probe and spherical applicators are consistent with literature reported measured values.

07 ISOTOPE AND RADIATION SOURCES↗
DOE OSTI2013

Experimental High Energy Physics Brandeis University Final Report

During the past three years, the Brandeis experimental particle physics group was comprised of four faculty (Bensinger, Blocker, Sciolla, and Wellenstein), one research scientist, one post doc, and ten graduate students. The group focused on the ATLAS experiment at LHC. In 2011, the LHC delivered 5/fb -1 of pp colliding beam data at a center-of-mass energy of 7 TeV. In 2012, the center-of-mass energy was increased to 8 TeV, and 20/fb -1 were delivered. The Brandeis group focused on two aspects of the ATLAS experiment $-$ the muon detection system and physics analysis. Since data taking began at the LHC in 2009, our group actively worked on ATLAS physics analysis, with an emphasis on exploiting the new energy regime of the LHC to search for indications of physics beyond the Standard Model. The topics investigated were Z' → ll, Higgs → ZZ* -. 4l, lepton flavor violation, muon compositeness, left-right symmetric theories, and a search for Higgs → ee. The Brandeis group has for many years been a leader in the endcap muon system, making important contributions to every aspect of its design and production. During the past three years, the group continued to work on commissioning the muon detector and alignment system, development of alignment software, and installation of remaining chambers.

72 PHYSICS OF ELEMENTARY PARTICLES AND FIELDS↗
DOE OSTI2015

An Investigation of Aerosol-Cloud-Precipitation Interactions in the South-East Pacific Using DOE G-1 Data and WRF/Chem Large Eddy Simulations

Under this grant, we investigated marine boundary layer clouds, their properties, behavior, and response to human activity and climate change, with a focus on scales and processes that cannot be studied with climate models. Investigated topics and results are summarized in this section. Detailed information are given in subsequent sections, followed by a list of resulting publications.

54 ENVIRONMENTAL SCIENCES↗
DOE OSTI2016

Helios: Understanding Solar Evolution Through Text Analytics

This proof-of-concept project focused on developing, testing, and validating a range of bibliometric, text analytic, and machine-learning based methods to explore the evolution of three photovoltaic (PV) technologies: Cadmium Telluride (CdTe), Dye-Sensitized solar cells (DSSC), and Multi-junction solar cells. The analytical approach to the work was inspired by previous work by the same team to measure and predict the scientific prominence of terms and entities within specific research domains. The goal was to create tools that could assist domain-knowledgeable analysts in investigating the history and path of technological developments in general, with a focus on analyzing step-function changes in performance, or “breakthroughs,” in particular. The text-analytics platform developed during this project was dubbed Helios. The project relied on computational methods for analyzing large corpora of technical documents. For this project we ingested technical documents from the following sources into Helios: Thomson Scientific Web of Science (papers), the U.S. Patent & Trademark Office (patents), the U.S. Department of Energy (technical documents), the U.S. National Science Foundation (project funding summaries), and a hand curated set of full-text documents from Thomson Scientific and other sources.

14 SOLAR ENERGY↗
DOE OSTI2022

Qualification of SAS4A/SASSYS-1 for Sodium-Cooled Fast Reactor Authorization and Licensing (Final CRADA Report)

This project focuses on assessment and qualification of the SAS4A/SASSYS-1 advanced reactor safety analysis code and its capacity to fulfill requirements associated with license/authorization of a sodium-cooled fast reactor (SFR). Specific objectives of this proposal include: development of a formal documentation requirements matrix that complies with a vendor’s NQA-1 program to identify needs for qualification documentation; completion of software methods qualification gap analysis to identify and close gaps in the verification and validation basis of the software; generation of an Acceptance Test Report to confirm compliance with the software requirements specification; and closure of gaps in Software Design Description (SDD) to assist with the eventual generation of a Modeling Licensing Topic Report (LTR).

21 SPECIFIC NUCLEAR REACTORS AND ASSOCIATED PLANTS↗
DOE OSTI2023

Water narratives in local newspapers within the United States

Sustainable use of water resources continues to be a challenge across the globe. This is in part due to the complex set of physical and social behaviors that interact to influence water management from local to global scales. Analyses of water resources have been conducted using a variety of techniques, including qualitative evaluations of media narratives. This study aims to augment these methods by leveraging computational and quantitative techniques from the social sciences focused on text analyses. Specifically, we use natural language processing methods to investigate a large corpus (approx. 1.8M) of newspaper articles spanning approximately 35 years (1982–2017) for insights into human-nature interactions with water. Focusing on local and regional United States publications, our analysis demonstrates important dynamics in water-related dialogue about drinking water and pollution to other critical infrastructures, such as energy, across different parts of the country. Our assessment, which looks at water as a system, also highlights key actors and sentiments surrounding water. Extending these analytical methods could help us further improve our understanding of the complex roles of water in current society that should be considered in emerging activities to mitigate and respond to resource conflicts and climate change.

54 ENVIRONMENTAL SCIENCES↗
DOE OSTI2023

Review: Inelastic Constitutive Modeling: Polycrystalline Materials

This article provides a literature review that details the development of inelastic constitutive modeling as it relates to polycrystalline materials. This review distinguishes between inelastic constitutive models that account for nonlinear behavior at the microstructural level, time-independent classic plasticity models, and time-dependent unified models. Particular emphasis is placed on understanding the underlying theoretical framework for unified viscoplasticity models where creep and classical plasticity behavior are considered the result of applied boundary conditions instead of separable rates representing distinct physical mechanisms. This article establishes a clear understanding of the advantages of the unified approach to improve material modeling. This review also discusses recent topics in constitutive modeling that offer new techniques that bridge the gap between the microstructure and the continuum.

36 MATERIALS SCIENCE↗
NASA NTRS1986

Simulation studies for surfaces and materials strength

During this reporting period three investigations were carried out. The first area of research concerned the analysis of the structure-energy relationship in small clusters. This study is very closely related to the improvement of the potential energy functions which are suitable and simple enough to be used in atomistic simulation studies. Parameters obtained from ab initio calculations for dimers and trimers of Al were used to estimate energetics and global minimum energy structures of clusters continuing up to 15 Al atoms. The second research topic addressed modeling of the collision process for atoms impinging on surfaces. In this simulation study qualitative aspects of the O atom collision with a graphite surface were analyzed. Four different O/graphite systems were considered and the aftermath of the impact was analyzed. The final area of investigation was related to the simulation of thin amorphous Si films on crystalline Si substrates. Parameters obtained in an earlier study were used to model an exposed amorphous Si surface and an a-Si/c-Si interface. Structural details for various film thicknesses were investigated at an atomistic level.

Halicioglu, T.↗
NASA NTRS1987

Studies of vortex dominated flows; Proceedings of the Symposium, Hampton, VA, July 9-11, 1985

Papers are presented on waves and bifurcations in vortex filaments, a ring-vortex representation of an axisymmetric vortex sheet, and comparison of experiment with the dynamics of the von Karman vortex trail. Also considered are force-free and loss-free transitions between vortex flow states, a vortex breakdown simulation based on a nonlinear inviscid method, and the prediction of highly vortical flows using an Euler equation model. Other topics include the theory of high-Reynolds-number flow past a blunt body, progress on the calculation of large-scale separation at high Reynolds numbers, and viscous-inviscid interaction solvers and computation of highly separated flows. Papers are also presented on simulation studies of vortex dynamics of a leading edge vortex flap, methods for numerical simulation of leading edge vortex flow, and comparison of measured and computed pitot pressures in a leading edge vortex from a delta wing.

Hussaini, M. Y.↗
NASA NTRS1987

Middle atmosphere trace constituents; Proceedings of Workshop 9 of the Twenty-sixth COSPAR Plenary Meeting, Toulouse, France, June 30-July 11, 1986

Papers are presented on a reference model for stratospheric NO2, a proposed reference model for nitric acid, proposed reference models for ozone, and a background stratospheric aerosol reference model. Other topics include a comparison between the observed and calculated distributions of trace species in the middle atmosphere, recent measurements of trace constituents from rocket and balloon probes, NO2 field observations in the stratosphere during the MAP/GLOBUS Campaign in 1983 and 1985, and the vertical distribution of ozone in the equatorial zone. Also considered are precision measurements of stratospheric ozone profiles by rocket-borne optical ozonesondes, vertical profiles of source gases at tropical latitudes, and measurements of stratospheric trace constituent distributions from balloon-borne far infrared observations.

Keating, G. M.↗
NASA NTRS1991

A discourse on sensitivity analysis for discretely-modeled structures

A descriptive review is presented of the most recent methods for performing sensitivity analysis of the structural behavior of discretely-modeled systems. The methods are generally but not exclusively aimed at finite element modeled structures. Topics included are: selections of finite difference step sizes; special consideration for finite difference sensitivity of iteratively-solved response problems; first and second derivatives of static structural response; sensitivity of stresses; nonlinear static response sensitivity; eigenvalue and eigenvector sensitivities for both distinct and repeated eigenvalues; and sensitivity of transient response for both linear and nonlinear structural response.

Adelman, Howard M.↗
NASA NTRS1992

Development and validation of techniques for improving software dependability

A collection of document abstracts are presented on the topic of improving software dependability through NASA grant NAG-1-1123. Specific topics include: modeling of error detection; software inspection; test cases; Magnetic Stereotaxis System safety specifications and fault trees; and injection of synthetic faults into software.

Knight, John C.↗
NASA NTRS1992

Papers Presented to the Workshop on the Evolution of the Martian Atmosphere

This volume contains papers that have been accepted for the Workshop on the Evolution of the Martian Atmosphere. The abstracts presented in the paper cover such topics as: modeling of the mars atmosphere from early development to present including specific conditions affecting development; studies of various atmospheric gases such as O2, SO2, CO2, NH3, and nitrogen; meteorite impacts and their effects on the atmosphere; and water inventories and cycles.

Source record↗