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Results for “Proliferation”

Search indexed NASA NTRS and DOE OSTI research on propulsion, heat transfer, battery materials and energy systems. Follow report and document links to the original sources.

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At least 145 records · Page 8
All sourcesNASA NTRSDOE OSTI
NASA NTRS1977

A method for reducing software life cycle costs

The advent of new hardware and software tools permits a new approach to preparing, presenting, and maintaining software specifications and corresponding source programs. Any real reduction in software life cycle costs must make highly skilled human effort more efficient especially on large, complex, and long-lasting software projects. When these skilled human functions are examined closely, it is seen that critical factors include the way one communicates with oneself and then with others and finally with computers. Thus, there has been a long and active proliferation of programming languages and, more recently, a number of programming design languages to supplement older methods, such as flowcharting. One way to achieve cost reduction is to provide documentation tools whose use increases the effectiveness of skilled humans.

Paine, W. O.↗
NASA NTRS1977

Carbon fiber study

A coordinated Federal Government action plan for dealing with the potential problems arising from the increasing use of graphite fiber reinforced composite materials in both military and civilian applications is presented. The required dissemination of declassified information and an outline of government actions to minimize the social and economic consequences of proliferated composite materials applications were included.

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NASA NTRS1979

Space Construction System Analysis. Special Emphasis Studies

Generic concepts were analyzed to determine: (1) the maximum size of a deployable solar array which might be packaged into a single orbit payload bay; (2) the optimal overall shape of a large erectable structure for large satellite projects; (3) the optimization of electronic communication with emphasis on the number of antennas and their diameters; and (4) the number of beams, traffic growth, and projections and frequencies were found feasible to package a deployable solar array which could generate over 250 kilowatts of electrical power. Also, it was found that the linear-shaped erectable structure is better for ease of construction and installation of systems, and compares favorably on several other counts. The study of electronic communication technology indicated that proliferation of individual satellites will crowd the spectrum by the early 1990's, so that there will be a strong tendency toward a small number of communications platforms over the continental U.S.A. with many antennas and multiple spot beams.

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NASA NTRS1979

Platforms in space: Evolutionary trends

The problem of physical crowding and the proliferation of separate communication links and ground support systems for multiple free-flying satellites can be overcome by using space platforms and multiplexing the data streams. Pertinent features of the space shuttle orbiter payloads, the solar power satellite, and geostationary and geosynchronous platforms are discussed. Typical payload requirements data which are needed to allow meaningful study of payloads as candidates for platform implementation are cited and factors affecting the compatibility/grouping of payloads are outlined.

Butler, J. M., Jr.↗
NASA NTRS1979

A regional technology transfer program

The proliferation of online searching capabilities among its industrial clients, changes in marketing staff and direction, use of Dun and Bradstreet marketing service files, growth of the Annual Service Package program, and services delivered to clients at the NASA funded North Carolina Science and Technology Research Center are described. The library search service was reactivated and enlarged, and a survey was conducted on the NC/STRC Technical Bulletin's effectiveness. Several quotations from clients assess the overall value of the Center's services.

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NASA NTRS1980

Developing the concept of a geostationary platform

A geostationary platform concept with a proliferation of low-cost earth stations is discussed. Candidate platform concepts, servicing, life, and Orbital Transfer Vehicle (OTV) options are considered. A Life Cycle Costing model is used to select the minimum cost concept meeting program criteria. It is concluded that the geostationary platform concept is a practical and economical approach to providing expanding communication services within the limitations imposed by the available frequency spectrum and orbital arc.

Carey, W. T.↗
NASA NTRS1980

Late degeneration in rabbit tissues after irradiation by heavy ions

Results are presented for investigations of the late effects of heavy-ion irradiation on rabbit tissues which were undertaken to assess the hazards associated with the long-term exposure of humans to heavy ions in space during such activities as the construction of solar power stations or voyages to Mars. White rabbits approximately six weeks old were exposed to various doses of collimated beams of 400-MeV/n Ne ions, 570 MeV/n Ar ions and Co-60 gamma rays directed through both eyes, and the responses of the various tissues (hair follicles, skin, cornea, lens, retina, Harderian glands, bone and forebrain) were examined. Proliferating tissues are found to exhibit high damage levels in the early and late periods following irradiation, while terminally differentiating tissues repond to radiation most intensely in the late period, years after irradiation, with no intermediate recovery. The results obtained from rabbits are used to predict the occurrence of late tissue degeneration in the central nervous system, terminally differentiating systems and stem cells of humans one or more decades following exposure to radiation levels anticipated during long-duration space flights. The studies also indicate that tissues may be prematurely aged in the sense that tissue life spans may be shortened without the development of malignancies.

Lett, J. T.↗
NASA NTRS1980

Evolution of a standard microprocessor-based space computer

An existing in inventory computer hardware/software package (B-1 RFS/ECM) was repackaged and applied to multiple missile/space programs. Concurrent with the application efforts, low risk modifications were made to the computer from program to program to take advantage of newer, advanced technology and to meet increasingly more demanding requirements (computational and memory capabilities, longer life, and fault tolerant autonomy). It is concluded that microprocessors hold promise in a number of critical areas for future space computer applications. However, the benefits of the DoD VHSIC Program are required and the old proliferation problem must be revised.

Fernandez, M.↗
NASA NTRS1981

The information systems heritage

This paper addresses key developments in the evolution of information systems over the past five decades. Major areas covered include the growth of imaging sensors from such pioneering devices as the iconoscope and orthicon which ushered in television, through a wide range of vidicon tubes, to the solid-state arrays which characterize current systems; the phenomenal expansion of electronic communications from telegraph and telephone wires, through the introduction of broadcast and microwave relay services, to the present era of worldwide satellite communications and data networks; and the key role of digital computers from their ancient precursors like the abacus and the mechanical calculating engines, through the appearance of the first large-scale electronic computers and their transistorized successors, to the rapid proliferation of miniaturized processors which impact every aspect of aerospace systems today.

Kurzhals, P. R.↗
NASA NTRS1981

Polyploidization delay in rat hepatocytes under liver growth inhibition by hypokinesia

A study of young rats, weighing 55 to 59 g, after being for 10 days in conditions of limited mobility, shows a retardation of body growth as well as that of liver growth. The decrease in the rate of growth is accompanied by a reduction of cell proliferation and by delay polyploidization of hepatocytes in the liver of experimental rats. The materials, methods, and results of research are discussed.

Faktor, V. M.↗
NASA NTRS1981

Neurotrophic factor - Characterization and partial purification

Recent evidence suggests that neurotrophic activity is required for the normal proliferation and development of muscle cells. The present paper reports a study of the purification and characterization of a neurotrophic factor (NTF) from adult chicken ischiatic-peroneal nerves using two independent quantitative in vitro assay systems. The assays were performed by the measurement of the incorporation of tritiated thymidine or the sizes of single-cell clones by chick muscle cells grown in culture. The greatest amount of neutrotrophic activity is found to be extracted at a pH of 8; aqueous suspensions of the activity are stable to long-term storage at room temperature. The specific activity of the substance is doubled upon precipitation with ammonium sulfate or after gel filtration, and increase 4 to 5 fold after salt gradient elution from DEAE cellulose columns. The active fraction obtained after gel filtration and rechromatography on DEAE cellulose exhibits a 7 to 10-fold increase in specific activity. Electrophoresis of the most highly purified material yields a greatly concentrated band at around 80,000 daltons. Although NTF is purified almost 10-fold as indicated by the increase in specific activity, the maximum activity of the partially purified material is greatly reduced, possibly due to a requirement for a cofactor for the expression of maximum activity.

Popiela, H.↗
NASA NTRS1982

Evolution of major metabolic innovations in the Precambrian

A combination of information on the metabolic capabilities of prokaryotes with a composite phylogenetic tree depicting an overview of prokaryote evolution based on the sequences of bacterial ferredoxin, 2Fe-2S ferredoxin, 5S ribosomal RNA, and c-type cytochromes shows three zones of major metabolic innovation in the Precambrian. The middle of these, which reflects the genesis of oxygen-releasing photosynthesis and aerobic respiration, links metabolic innovations of the anaerobic stem on the one hand and, on the other, proliferation of aerobic bacteria and the symbiotic associations leading to the eukaryotes. Those pathways where information on the structure of the enzymes is known are especially considered. Halobacterium and Thermoplasma (archaebacteria) do not belong to a totally independent line on the basis of the composite tree but branch from the eukaryote cytoplasmic line.

Barnabas, J.↗
NASA NTRS1984

Computer simulation of protein systems

Ligand binding to dihydrofolate reductase (DHFR) is discussed. This is an extremely important enzyme, as it is the target of several drugs (inhibitors) which are used clinically as antibacterials, antiprotozoals and in cancer chemotherapy. DHFR catalyzes the NADPH (reduced nicotinamide adenine dinucleotide phosphate) dependent reduction of dihydrofolate to tetrahydrofolate, which is used in several pathways of purine and pyrimidine iosynthesis, including that of thymidylate. Since DNA synthesis is dependent on a continuing supply of thymidylate, a blockade of DHFR resulting in a depletion of thymidylate can lead to the cessation of growth of a rapidly proliferating cell line. DHFR exhibits a significant species to species variability in its sensitivity to various inhibitors. For example, trimethoprim, an inhibitor of DHFR, binds to bacterial DHFR's 5 orders of magnitude greater than to vertebrate DHFR's. The structural mechanics, dynamics and energetics of a family of dihydrofolate reductases are studied to rationalize the basis for the inhibitor of these enyzmes and to understand the molecular basis of the difference in the binding constants between the species. This involves investigating the conformational changes induced in the protein on binding the ligand, the internal strain imposed by the enzyme on the ligand, the restriction of fluctuations in atom positions due to binding and the consequent change in entropy.

Osguthorpe, D. J.↗
NASA NTRS1984

Interferon induces natural killer cell blastogenesis in vivo

Interferon (IFN), types beta and gamma, and IFN inducers polyinosinic-polycytidylic acid and lymphocytic choriomeningitis virus, all stimulated the generation of blast-natural killer (NK) cells in mouse spleens, Blast-NK cells were characterized on the basis of size, 3H-thymidine uptake, and NK cell markers These data indicate that in addition to augmenting NK cell-mediated lysis, IFN may regulate NK cell proliferation in vivo.

Biron, C. A.↗
NASA NTRS1985

Standard Codes for Telemetry and Telecommand

Different systems communicate and development costs reduced. Report discusses efforts to standardize telemetry and telecommand codes of various space programs. Used to detect and correct bit errors in communication channels with low signal-to-noise ratios, codes proliferated in recent years. Each coding/decoding system developed to solve specific problem, but some systems are similar and exhibit similar performance.

Macmedan, M. L.↗
NASA NTRS1985

Properties of electrophoretic fractions of human embryonic kidney cells separated on space shuttle flight STS-8

Suspensions of cultured primary human embryonic kidney cells were subjected to continuous flow electrophoresis on Space Shuttle flight STS-8. The objectives of the experiments were to obtain electrophoretically separated fractions of the original cell populations and to test these fractions for the amount and kind of urokinase (a kidney plasminogen activator that is used medically for digesting blood clots), the morphologies of cells in the individual fractions, and their cellular electrophoretic mobilities after separation and subsequent proliferation. Individual fractions were successfully cultured after return from orbit, and they were found to differ substantially from one another and from the starting sample with respect to all of these properties.

Morrison, D. R.↗
NASA NTRS1984

Circadian rhythm of mechanically mediated differentiation of osteoblasts

The differential of osteoblasts in response to orthodontic pressure in the periodontal ligament of the maxillary-first-molar periodontal ligaments of 12-h-light/dark-entrained 7-wk-old male Simonsen outbred rats is measured by (H-3)-Thymidine nuclear-volume morphometry (Roberts et al., 1983) at hourly intervals throughout the circadian cycle. The results are presented in graphs and discussed. Preosteoblast large nuclei (D-cells) are found to synthesize DNA mainly in light and to divide in the following dark period, while small-nucleus osteoprogenitors (A-cells) synthesize in darkness and divide in light. These findings are seen as consistent with a model in which the sequence of proliferation and differentiation requires at least 60 h (five 12-h periods) and the shift from A to D cells lasts about 19 h.

Roberts, W. E.↗
NASA NTRS1985

Photovoltaic performance models - A report card

Models for the analysis of photovoltaic (PV) systems' designs, implementation policies, and economic performance, have proliferated while keeping pace with rapid changes in basic PV technology and extensive empirical data compiled for such systems' performance. Attention is presently given to the results of a comparative assessment of ten well documented and widely used models, which range in complexity from first-order approximations of PV system performance to in-depth, circuit-level characterizations. The comparisons were made on the basis of the performance of their subsystem, as well as system, elements. The models fall into three categories in light of their degree of aggregation into subsystems: (1) simplified models for first-order calculation of system performance, with easily met input requirements but limited capability to address more than a small variety of design considerations; (2) models simulating PV systems in greater detail, encompassing types primarily intended for either concentrator-incorporating or flat plate collector PV systems; and (3) models not specifically designed for PV system performance modeling, but applicable to aspects of electrical system design. Models ignoring subsystem failure or degradation are noted to exclude operating and maintenance characteristics as well.

Smith, J. H.↗