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At least 145 records · Page 8
All sourcesNASA NTRSDOE OSTI
NASA NTRS2001

Relationship between early diastolic intraventricular pressure gradients, an index of elastic recoil, and improvements in systolic and diastolic function

BACKGROUND: Early diastolic intraventricular pressure gradients (IVPGs) have been proposed to relate to left ventricular (LV) elastic recoil and early ventricular "suction." Animal studies have demonstrated relationships between IVPGs and systolic and diastolic indices during acute ischemia. However, data on the effects of improvements in LV function in humans and the relationship to IVPGs are lacking. METHODS AND RESULTS: Eight patients undergoing CABG and/or infarct exclusion surgery had a triple-sensor high-fidelity catheter placed across the mitral valve intraoperatively for simultaneous recording of left atrial (LA), basal LV, and apical LV pressures. Hemodynamic data obtained before bypass were compared with those with similar LA pressures and heart rates obtained after bypass. From each LV waveform, the time constant of LV relaxation (tau), +dP/dt(max), and -dP/dt(max) were determined. Transesophageal echocardiography was used to determined end-diastolic (EDV) and end-systolic (ESV) volumes and ejection fractions (EF). At similar LA pressures and heart rates, IVPG increased after bypass (before bypass 1.64+/-0.79 mm Hg; after bypass 2.67+/-1.25 mm Hg; P<0.01). Significant improvements were observed in ESV, as well as in apical and basal +dP/dt(max), -dP/dt(max), and tau (each P<0.05). Overall, IVPGs correlated inversely with both ESV (IVPG=-0.027[ESV]+3.46, r=-0.64) and EDV (IVPG=-0.027[EDV]+4.30, r=-0.70). Improvements in IVPGs correlated with improvements in apical tau (Deltatau =5.93[DeltaIVPG]+4.76, r=0.91) and basal tau (Deltatau =2.41[DeltaIVPG]+5.13, r=-0.67). Relative changes in IVPGs correlated with changes in ESV (DeltaESV=-0.97[%DeltaIVPG]+23.34, r=-0.79), EDV (DeltaEDV=-1.16[%DeltaIVPG]+34.92, r=-0.84), and EF (DeltaEF=0.38[%DeltaIVPG]-8.39, r=0.85). CONCLUSIONS: Improvements in LV function also increase IVPGs. These changes in IVPGs, suggestive of increases in LV suction and elastic recoil, correlate directly with improvements in LV relaxation and ESV.

Non-NASA Center↗
NASA NTRS2007

Relative Bioavailability of Scopolamine Dosage Forms and Interaction with Dextroamphetamine

The NASA Reduced Gravity Office (RGO) uses scopolamine (SCOP) and in combination with dextoamphetamine (DEX) to manage motion sickness symptoms during parabolic flights. The medications are dispensed as custom dosage forms as gelatin capsules. Anecdotal evidence of efficacy suggests that these formulations are unreliable and less efficacious for the treatment of motion sickness. We estimated bioavailability of four different oral formulations used by NASA for the treatment of motion sickness. Twelve healthy, non-smoking subjects between 21and 48 years of age received four treatments on separate days in a randomized fashion; the treatments were 0.8 mg SCOP alone as tablet, 0.8 mg SCOP alone in gel cap, 0.8 mg SCOP and 10 mg DEX as tablets, and 0.8 mg SCOP and 10 mg DEX in gel cap. After each treatment, blood, saliva, and urine samples were collected at scheduled time intervals for 24 h after dosing. Bioavailability and pharmacokinetic parameters were calculated and compared using ANOVA. After administration of SCOP tablets alone, maximum concentration (C(sub max)) and time for maximum concentration (t(sub max)) were 0.26 plus or minus 0.04 ng/mL and 0.71 plus or minus 0.02 h, respectively; volume of distribution, and clearance were 47.6 plus or minus 4.72 L/kg and 23.0 plus or minus 4.58 L/h/kg, respectively. SCOP t(sub max) after administration as gelcaps was significantly longer than that with tablets (1.04 h, p less than 0.05), but no significant differences in other pharmacokinetic parameters of SCOP were observed between the two dosage forms. When coadministered with DEX, the area underneath the concentration versus time curve (AUC) of SCOP was significantly reduced to 0.61 plus or minus 0.09 and 0.64 plus or minus 0.11 ng (raised dot) h/mL after administration as a tablet or gelcap formulation, respectively; SCOP C(sub max) was lower after coadministration with DEX, this difference, however, was not statistically significant. Delayed absorption with gelcaps coupled with reduced bioavailability with DEX coadministration may have resulted in the observed treatment failure with some of these formulations. This could result from failure to reach minimum effective concentrations after treatment with gelcap formulations before parabolic flights. A new nomogram for dosing is proposed for treatment with SCOP gelcaps or SCOP-DEX combination.

Boyd, Jason L.↗
NASA NTRS2010

The Biological Effectiveness of Silicon Ions is Significantly Higher than Iron Ions for the Induction of Chromosome Damage in Human Lymphocytes

Chromosome aberrations were measured in human peripheral blood lymphocytes after in vitro exposure to Si-28-ions with energies ranging from 90 to 600 MeV/u, or Fe-56-ions with energies ranging from 200 to 5,000 MeV/u. The LET of the various Fe beams in this study ranged from 145 to 440 keV/micron and the LET Si ions ranged from 48 to 158 keV/micron. Doses delivered were in the 10 to 200 cGy range. Dose response curves for chromosome exchanges in cells at first division after exposure, measured using fluorescence in situ hybridization (FISH) with whole chromosome probes, were fitted with linear or linear-quadratic functions. The relative biological effectiveness (RBE) was estimated from the initial slope of the dose response curve for chromosome damage with respect to gamma-rays. The estimates of RBE(sub max) values for total chromosome exchanges ranged from 4.4+/-0.4 to 31.5+/-2.6 for Fe ions, and 11.8+/-1.0 to 42.2+/-3.3 for Si ions. The highest RBE(sub max) value for Fe ions was obtained with the 600 Mev/u beam and 170 MeV/u beam produced the highest RBE(sub max) value for Si ions. For both ions the RBE(sub max) values increased with LET, reaching a maximum at about 180 keV/micron for Fe and about 100 keV/micron for Si, and decreased with further increase in LET.

George, Kerry↗
NASA NTRS1959

The Problem of Obtaining High Lift-Drag Ratios at Supersonic Speeds

The importance of the lift to drag ratio is well known to all aircraft designers since it gives, to a great extent, the aerodynamic efficiency of the airplane. Aerodynamic efficiency, however, is only one component of the grand compromise that a completed airplane represents. At subsonic speeds, lift-drag ratios of well over 200 have been measured in wind tunnels on airfoil sections; but few powered aircraft have attained (L/D) value of 20. It is invariably true that the requirements of stability and control, structure, and flight operation all contribute to reducing the design (L/D) (sub max)) considerably below those exotic values which can be predicted from unrestricted aerodynamic theory. If, however, a certain range or operating efficiency is required, there is most certainly a minimum (L/D) (sub max)) value for which the goals are just attainable. If we examine the range equation we see that range is proportional to the lift-drag ratio, the thermopropulsive efficiency, and the logarithm of the initial to final weight ratio. The appearance of the lift-drag ratio as a linear factor in the range equation indicates that every attempt should be made to increase (L/D) (sub max)); however, the search for higher (L/D)max may lead to strange and unorthodox configurations. Most frequently, such configurations are ruled out by the adverse effects of their geometry on the weight ratios. In the present paper, we will deal with the maximum lift-drag ratio problem for conventional configurations having a wing and a body in close proximity to each other. No attempt will be made to select a particular configuration as being the best. However, the promising direction to go from the aerodynamic view will be stressed with the understanding that the other factors may outweight the aerodynamics

Brown, Clinton E.↗
NASA NTRS2017

Comparison of Commonly-Used Microwave Radiative Transfer Models for Snow Remote Sensing

This paper reviews four commonly-used microwave radiative transfer models that take different electromagnetic approaches to simulate snow brightness temperature (T(sub B)): the Dense Media Radiative Transfer - Multi-Layer model (DMRT-ML), the Dense Media Radiative Transfer - Quasi-Crystalline Approximation Mie scattering of Sticky spheres (DMRT-QMS), the Helsinki University of Technology n-Layers model (HUT-nlayers) and the Microwave Emission Model of Layered Snowpacks (MEMLS). Using the same extensively measured physical snowpack properties, we compared the simulated T(sub B) at 11, 19 and 37 GHz from these four models. The analysis focuses on the impact of using different types of measured snow microstructure metrics in the simulations. In addition to density, snow microstructure is defined for each snow layer by grain optical diameter (Do) and stickiness for DMRT-ML and DMRT-QMS, mean grain geometrical maximum extent (D(sub max)) for HUT n-layers and the exponential correlation length for MEMLS. These metrics were derived from either in-situ measurements of snow specific surface area (SSA) or macrophotos of grain sizes (D(sub max)), assuming non-sticky spheres for the DMRT models. Simulated T(sub B) sensitivity analysis using the same inputs shows relatively consistent T(sub B) behavior as a function of Do and density variations for the vertical polarization (maximum deviation of 18 K and 27 K, respectively), while some divergences appear in simulated variations for the polarization ratio (PR). Comparisons with ground based radiometric measurements show that the simulations based on snow SSA measurements have to be scaled with a model-specific factor of Do in order to minimize the root mean square error (RMSE) between measured and simulated T(sub B). Results using in-situ grain size measurements (SSA or D(sub max), depending on the model) give a mean T(sub B) RMSE (19 and 37 GHz) of the order of 16-26 K, which is similar for all models when the snow microstructure metrics are scaled. However, the MEMLS model converges to better results when driven by the correlation length estimated from in-situ SSA measurements rather than D(sub max) measurements. On a practical level, this paper shows that the SSA parameter, a snow property that is easy to retrieve in-situ, appears to be the most relevant parameter for characterizing snow microstructure, despite the need for a scaling factor.

Snow↗
NASA NTRSDate not supplied

Ice Accretion Roughness Variations on a Hybrid CRM65-Midspan Wing Model

Ice accretion roughness measurements were performed in the Icing Research Tunnel (IRT) at NASA Glenn Research Center for the Hybrid CRM65-Midspan model in a range of icing conditions. The Hybrid CRM65-Midspan model was chosen for this investigation because 1) the model exhibits high sweep relative to models previously explored in the roughness investigations, 2) the model has leading edge characteristics similar to wing shapes currently used in mid-size commercial airliners, and 3) the sweep and thickness ratios relate better to hybrid lifting body designs for N+2 and N+3 vehicles than other models available. The investigation consisted of multiple sets of tests which focused on 1) 0-angle of attack cases replicating the conditions employed by Anderson et al. (1998) using both Appendix C and SLD cloud conditions, 2) cases based on the “Max Scallop” case by Broeren et al. (2016) and a “High Temperature” case with cloud properties similar to the “Max Scallop” case. Additional tests were performed 1) based on the “Max Scallop” case with variations in freestream static temperature and 2) using test section speeds near 10,000-hold flight conditions. The point clouds were characterized using the approach of McClain and Kreeger (2013) for the ice roughness variations and using the approach of McClain (2016) for the mean ice thickness variations. The resulting roughness and mean thickness variations generally follow the temporal scaling previously identified using on airfoil models without sweep, but the collapse of the time progression profiles is not as tight as found for past measurements on models without sweep. LEWICE and modified panel-method predictions were used explore spatial roughness variations and to compare to the roughness correlations developed by McClain et al. (2021) for the “Max Scallop” cases.

Icing↗
NASA NTRS2020

Streaming Instability with Multiple Dust Species – I. Favourable Conditions for the Linear Growth

A recent study suggests that the streaming instability, one of the leading mechanisms for driving the formation of planetesimals, may not be as efficient as previously thought. Under some disc conditions, the growth time-scale of the instability can be longer than the disc lifetime when multiple dust species are considered. To further explore this finding, we use both linear analysis and direct numerical simulations with gas fluid and dust particles tomutually validate and study the unstablemodes of the instability in more detail.We extend the previously studied parameter space by one order of magnitude in both the range of the dust-size distribution [Ts, min, Ts, max] and the total solid-to-gas mass ratio ε and introduce a third dimension with the slope q of the size distribution. We find that the fast-growth regime and the slow-growth regime are distinctly separated in the ε–Ts, max space, while this boundary is not appreciably sensitive to q or Ts, min.With a wide range of dust sizes present in the disc (e.g. Ts, min  10−3), the growth rate in the slow-growth regime decreases as more dust species are considered.With a narrow range of dust sizes (e.g. Ts, max/Ts, min = 5), on the other hand, the growth rate in most of the ε–Ts, max space is converged with increasing dust species, but the fast and the slow growth regimes remain clearly separated. Moreover, it is not necessary that the largest dust species dominate the growth of the unstable modes, and the smaller dust species can affect the growth rate in a complicated way. In any case, we find that the fast-growth regime is bounded by ε  1 or Ts, max  1, which may represent the favourable conditions for planetesimal formation.

Zhaohuan Zhu↗
NASA NTRS1979

Annealing of radiation damage in 0.1- and 2-ohm-centimeter Silicon solar cells

Isochronal and isothermal annealing studies were conducted on 0.1 and 2 ohm centimeter n(+)/p silicon cells after irradiation by 1 MeV electrons at fluences of 10 to the 14th power, 5 times 10 to the 14th power, and 10 to the 15th power per square centimeter. For the 0.1 ohm centimeter cells, reverse annealing was not observed in the isochronal data. However, reverse annealing was observed between approximately 200 and 325 C in the isochronal data of the 2 ohm centimeter cells. Isothermal annealing of 0.1 ohm centimeter cells at 500 C restored pre-irradiation maximum power P sub max within 20 minutes at fluence = 10 to the 14th power, in 180 minutes at fluence = 5 times 10 to the 14th power and to 92 percent of pre-irradiation P sub max in 180 minutes for fluence = 10 to the 15th power. Annealing at 450 C was found inadequate to restore 0.1 ohm centimeter cell performance within reasonable times for all fluence levels. By comparison, at 450 C, the P sub max of 2 ohm centimeter cells was restored within 45 minutes, for the two highest fluence levels, while for the lowest fluence, restoration was completed within 15 minutes. Spectral response data indicate that, for both resistivities, degradation occurs predominantly in the cells p-type base region.

Weinberg, I.↗
NASA NTRS1978

Predicted color excess ratios versus interstellar grain size

Various color excess ratios, the ratio (R) of total to selective extinction, and values of the wavelength of maximum interstellar linear polarization (lambda max) are computed and displayed as functions of mean interstellar grain size and absorption coefficients. E(V-K)/E(B-V)-E(u-b)/E(b-y) is shown to be highly sensitive to changes of mean grain size. The shape of the R versus lambda max curve is shown to depend on the amount of absorption initially present in the grains, and on the absorptivity of the material added to the grains. While no simple model of grain growth has been found to fit all the observations, the two stars with the largest values of lambda max (HD 147889 and W67) support the concept of dielectric mantles growing on dielectric grains. It is further shown that more accurate uby and JKL photometry of heavily reddened stars would permit better discrimination between grain growth theories.

Mcmillan, R. S.↗
NASA NTRS1981

Bacterial biomass and heterotrophic potential in the waters of the Chesapeake Bay plume and contiguous continental shelf

Seasonal baseline data on bacterial biomass and heterotrophic uptake in the Chesapeake Bay plume and contiguous Atlantic Ocean shelf waters are discussed. Viable count bacterial numbers in surface water samples collected during June 1980 ranged from a maximum of 190,000 MPN (most probable number)/ml at the Bay mouth to a minimum of 7900 MPN/ml offshore. Similarly, direct count densities ranged from 1,800,000 BU (bacterial units)/ml to 24,000 BU/ml. Heterotrophic potential (V max) was largest at the Bay mouth and lowest offshore. Biomass and V max values usually decreased with depth although subsurface maxima were occasionally observed at inshore stations. Correlation of biomass and heterotrophic potential data with selected hydrographic variables was determind with a nonparametric statistic. Results indicate viable counts are positively and significantly correlated with total chlorophyll, temperature, direct count and V max during June 1980; significant negative correlations are obtained with salinity and depth. Calculations of bacterial standing crop are discussed.

Kator, H. I.↗
NASA NTRS1983

Cardiovascular responses to exercise as functions of absolute and relative work load

The roles of absolute and relative oxygen uptake (VO2 and percent of muscle group specific VO2-max) as determinants of the cardiovascular and ventilatory responses to exercise over a wide range of active muscle mass are investigated. Experiments were conducted using four types of dynamic exercise: one-arm curl, one-arm cranking, and one and two-leg cycling at four different relative work loads (25, 50, 75, and 100 percent of VO2-max) for the corresponding muscle group. Results show that VO2 during maximal one-arm curl, one-arm cranking, and one-leg cycling averaged 20, 50, and 75 percent, respectively, of that for maximal two-leg cycling. Cardiac output was determined to be linearly related to VO2 with a similar slope and intercept for each type of exercise, and the heart rate at a given percent VO2-max was higher with larger active muscle mass. It is concluded that the cardiovascular responses to exercise was determined to a large extent by the active muscle mass and the absolute oxygen uptake, with the principal feature appearing to be the tight linkage between systematic oxygen transport and utilization.

Lewis, S. F.↗
NASA NTRS1984

Effect of humidity on fretting wear of several pure metals

Fretting wear experiments with several pure metals were conducted in air at various relative humidity levels. The materials used were iron, aluminum, copper, silver, chromium, titanium, and nickel. Each pure metal had a maximum fretting wear volume at a specific humidity level RH sub max that was not dependent on mechanical factors such as contact load, fretting amplitude, and frequency in the ranges studied. The weight loss due to fretting wear at RH sub max for each pure metal decreased with increasing heat of oxygen adsorption on the metal, indicating that adhesive wear dominated at RH sub max.

Goto, H.↗
NASA NTRS1984

Thermal-mechanical fatigue crack growth in Inconel X-750

Thermal-mechanical fatigue crack growth (TMFCG) was studied in a gamma-gamma' nickel base superalloy Inconel X-750 under controlled load amplitude in the temperature range from 300 to 650 C. In-phase (T sub max at sigma sub max), out-of-phase (T sub min at sigma sub max), and isothermal tests at 650 C were performed on single-edge notch bars under fully reversed cyclic conditions. A dc electrical potential method was used to measure crack length. The electrical potential response obtained for each cycle of a given wave form and R value yields information on crack closure and crack extension per cycle. The macroscopic crack growth rates are reported as a function of delta k and the relative magnitude of the TMFCG are discussed in the light of the potential drop information and of the fractographic observations.

Marchand, N.↗
NASA NTRS1986

The solar maximum satellite capture cell: Impact features and orbital debris and micrometeoritic projectile materials

The physical properties of impact features observed in the Solar Max main electronics box (MEB) thermal blanket generally suggest an origin by hypervelocity impact. The chemistry of micrometeorite material suggests that a wide variety of projectile materials have survived impact with retention of varying degrees of pristinity. Impact features that contain only spacecraft paint particles are on average smaller than impact features caused by micrometeorite impacts. In case both types of materials co-occur, it is belevied that the impact feature, generally a penetration hole, was caused by a micrometeorite projectile. The typically smaller paint particles were able to penetrate though the hole in the first layer and deposit in the spray pattern on the second layer. It is suggested that paint particles have arrived with a wide range of velocities relative to the Solar Max satellite. Orbiting paint particles are an important fraction of materials in the near-Earth environment. In general, the data from the Solar Max studies are a good calibration for the design of capture cells to be flown in space and on board Space Station. The data also suggest that development of multiple layer capture cells in which the projectile may retain a large degree of pristinity is a feasible goal.

Mckay, D. S.↗
NASA NTRS1985

Thermal-mechanical fatigue crack growth in Inconel X-750

Thermal-mechanical fatigue crack growth (TMFCG) was studied in a 'gamma-gamma' nickel base superalloy Inconel X-750 under controlled load amplitude in the temperature range from 300 to 650 C. In-phase (T sub max at sigma sub max), out-of-phase (T sub min at sigma sub max), and isothermal tests at 650 C were performed on single-edge notch bars under fully reversed cyclic conditions. A dc electrical potential method was used to measure crack length. The electrical potential response obtained for each cycle of a given wave form and R value yields information on crack closure and crack extension per cycle. The macroscopic crack growth rates are reported as a function of delta k and the relative magnitude of the TMFCG are discussed in the light of the potential drop information and of the fractographic observations.

Marchand, N.↗
NASA NTRS1988

Isothermal and bithermal thermomechanical fatigue behavior of a NiCoCrAlY-coated single crystal superalloy

Specimens of single crystal PWA 1480 with group of zone axes (100) orientation, bare, or with NiCoCrAlY coating PWA 276, were tested in low cycle fatigue (LCF) at 650, 870, and 1050 C, and in simplified bithermal thermomechanical fatigue (TMF) tests between these temperatures. These tests were examined as a bridge between isothermal LCF and general TMF. In the bithermal test, an inelastic strain is applied at one temperature, T sub max, and reversed at T sub min. The out-of-phase (OP) test type imposing tension at T sub min and compression at T sub max received most study, since it was more damaging than the in-phase type. Specifically investigated were the effects of: inelastic strain range, the coating, delta T, T sub max, T sub min, and the environment.

Gayda, J.↗
NASA NTRS1988

On the relationship between optical polarization and extinction

A sample of stars including lines of sight within various dense clouds and stars in the diffuse interstellar medium are examined in order to investigate the relationship between various color ratios and the wavelength of the maximum of the interstellar polarization, lambda(max). The correlation of Serkowski (1975) is confirmed. The extinction laws have been fitted by minimizing the square deviations from the observed colors and the derived law. The results suggest that variations in lambda(max) are caused by differences in particle size distributions. Stars with large lambda(max) are noted in the outer regions of dense clouds, regions which are probably disturbed.

Clayton, Geoffrey C.↗
NASA NTRS1988

Isothermal and 'bithermal' thermomechanical fatigue behavior of a NiCoCrAlY-coated single crystal superalloy

Specimens of single crystal PWA 1480 with group of zone axes (100) orientation, bare, or with NiCoCrAlY coating PWA 276, were tested in low cycle fatigue (LCF) at 650, 870, and 1050 C, and in simplified bithermal thermomechanical fatigue (TMF) tests between these temperatures. These tests were examined as a bridge between isothermal LCF and general TMF. In the bithermal test, and inelastic strain is applied at one temperature, T sub max, and reversed at T sub min. The out-of-phase (OP) test type imposing tension at T sub min and compression at T sub max received most study, since it was more damaging than the in-phase type. Specifically investigated were the effects of: inelastic strain range, the coating, delta T, T sub max, T sub min, and the environment.

Gayda, J.↗