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At least 145 records · Page 8

Evaluation and Characterization Study of Dual Pulse Laser-Induced Spark (DPLIS) for Rocket Engine Ignition System Application

This paper addresses the progress of technology development of a laser ignition system at NASA Marshall Space Flight Center (MSFC). Laser ignition has been used at MSFC in recent test series to successfully ignite RP1/GOX propellants in a subscale rocket chamber, and other past studies by NASA GRC have demonstrated the use of laser ignition for rocket engines. Despite the progress made in the study of this ignition method, the logistics of depositing laser sparks inside a rocket chamber have prohibited its use. However, recent advances in laser designs, the use of fiber optics, and studies of multi-pulse laser formats3 have renewed the interest of rocket designers in this state-of the-art technology which offers the potential elimination of torch igniter systems and their associated mechanical parts, as well as toxic hypergolic ignition systems. In support of this interest to develop an alternative ignition system that meets the risk-reduction demands of Next Generation Launch Technology (NGLT), characterization studies of a dual pulse laser format for laser-induced spark ignition are underway at MSFC. Results obtained at MSFC indicate that a dual pulse format can produce plasmas that absorb the laser energy as efficiently as a single pulse format, yet provide a longer plasma lifetime. In an experiments with lean H2/air propellants, the dual pulse laser format, containing the same total energy of a single laser pulse, produced a spark that was superior in its ability to provide sustained ignition of fuel-lean H2/air propellants. The results from these experiments are being used to optimize a dual pulse laser format for future subscale rocket chamber tests. Besides the ignition enhancement, the dual pulse technique provides a practical way to distribute and deliver laser light to the combustion chamber, an important consideration given the limitation of peak power that can be delivered through optical fibers. With this knowledge, scientists and engineers at Los Alamos National Laboratory and CFD Research Corporation have designed and fabricated a miniaturized, first-generation optical prototype of a laser ignition system that could be the basis for a laser ignition system for rocket applications. This prototype will be tested at MSFC in future subscale rocket ignition tests.

Osborne, Robin↗

Thermodynamic Analysis of Dual-Mode Scramjet Engine Operation and Performance

Recent analytical advances in understanding the performance continuum (the thermodynamic spectrum) for air-breathing engines based on fundamental second-law considerations have clarified scramjet and ramjet operation, performance, and characteristics. Second-law based analysis is extended specifically in this work to clarify and describe the performance characteristics for dual-mode scramjet operation in the mid-speed range of flight Mach 4 to 7. This is done by a fundamental investigation of the complex but predictable interplay between heat release and irreversibilities in such an engine; results demonstrate the flow and performance character of the dual mode regime and of dual mode transition behavior. Both analytical and computational (multi-dimensional CFD) studies of sample dual-mode flow-fields are performed in order to demonstrate the second-law capability and performance and operability issues. The impact of the dual-mode regime is found to be characterized by decreasing overall irreversibility with increasing heat release, within the operability limits of the system.

Riggins, David↗

Experimental Study of an Axisymmetric Dual Throat Fluidic Thrust Vectoring Nozzle for Supersonic Aircraft Application

An axisymmetric version of the Dual Throat Nozzle concept with a variable expansion ratio has been studied to determine the impacts on thrust vectoring and nozzle performance. The nozzle design, applicable to a supersonic aircraft, was guided using the unsteady Reynolds-averaged Navier-Stokes computational fluid dynamics code, PAB3D. The axisymmetric Dual Throat Nozzle concept was tested statically in the Jet Exit Test Facility at the NASA Langley Research Center. The nozzle geometric design variables included circumferential span of injection, cavity length, cavity convergence angle, and nozzle expansion ratio for conditions corresponding to take-off and landing, mid climb and cruise. Internal nozzle performance and thrust vectoring performance was determined for nozzle pressure ratios up to 10 with secondary injection rates up to 10 percent of the primary flow rate. The 60 degree span of injection generally performed better than the 90 degree span of injection using an equivalent injection area and number of holes, in agreement with computational results. For injection rates less than 7 percent, thrust vector angle for the 60 degree span of injection was 1.5 to 2 degrees higher than the 90 degree span of injection. Decreasing cavity length improved thrust ratio and discharge coefficient, but decreased thrust vector angle and thrust vectoring efficiency. Increasing cavity convergence angle from 20 to 30 degrees increased thrust vector angle by 1 degree over the range of injection rates tested, but adversely affected system thrust ratio and discharge coefficient. The dual throat nozzle concept generated the best thrust vectoring performance with an expansion ratio of 1.0 (a cavity in between two equal minimum areas). The variable expansion ratio geometry did not provide the expected improvements in discharge coefficient and system thrust ratio throughout the flight envelope of typical a supersonic aircraft. At mid-climb and cruise conditions, the variable geometry design compromised thrust vector angle achieved, but some thrust vector control would be available, potentially for aircraft trim. The fixed area, expansion ratio of 1.0, Dual Throat Nozzle provided the best overall compromise for thrust vectoring and nozzle internal performance over the range of NPR tested compared to the variable geometry Dual Throat Nozzle.

Flamm, Jeffrey D.↗

Developing Lightning Prediction Tools for the CCAFS Dual-Polarimetric Radar

NASA Marshall Space Flight Center and the University of Alabama Huntsville are collaborating with the 45th Weather Squadron (45WS) to develop improved lightning prediction capabilities for the new C-band dual-polarimetric weather radar being acquired for use by 45WS and launch weather forecasters at Cape Canaveral Air Force Station (CCAFS). In particular, these algorithms will focus on lightning onset, cessation and combined lightning-radar applications for convective winds assessment. Research using radar reflectivity (Z) data for prediction of lightning onset has been extensively discussed in the literature and subsequently applied by launch weather forecasters as it pertains to lightning nowcasting. Currently the forecasters apply a relatively straight forward but effective temperature-Z threshold algorithm for assessing the likelihood of lightning onset in a given storm. In addition, a layered VIL above the freezing level product is used as automated guidance for the onset of lightning. Only limited research and field work has been conducted on lightning cessation using Z and vertically-integrated Z for determining cessation. Though not used operationally vertically-integrated Z (basis for VIL) has recently shown promise as a tool for use in nowcasting lightning cessation. The work discussed herein leverages and expands upon these and similar reflectivity-threshold approaches via the application/addition of over two decades of polarimetric radar research focused on distinct multi-parameter radar signatures of ice/mixed-phase initiation and ice-crystal orientation in highly electrified convective clouds. Specifically, our approach is based on numerous previous studies that have observed repeatable patterns in the behavior of the vertical hydrometeor column as it relates to the temporal evolution of differential reflectivity and depolarization (manifested in either LDR or p(sub hv)), development of in-situ mixed and ice phase microphysics, electric fields, and ensuing lightning in the sub-tropical/tropical convection typical of the southeastern U.S., Maritime Continent, and southwestern Amazon. The polarimetric signatures detected in this setting provide a basis for automated 3-D detection of hydrometeor types in fuzzy logic hydrometeor identification algorithms (HID). Our working hypothesis is that improvement in lightning onset warning lead time and specificity for a given storm, relative to application of a Z-threshold algorithm, should arise as a consequence of the ability of dual-polarimetric radar to unambiguously detect and identify (through HID algorithms) the updraft elevation of rain-water cores above the freezing level and subsequent onset of drop freezing, riming, and robust mixed phase processes leading to significant charge separation and lightning. This type of algorithm, though dependent on the quality of the polarimetric data should be less susceptible to variable Z-calibration that can impact a given Z-threshold approach. To facilitate development of the algorithm while the 45WS dual-pol radar is in its current test stages and to evaluate the impact of polarimetric data quality (e.g., modified scan parameters and sampling) on the ensuing algorithms, we are using the ARMOR C-band dual-pol radar in Huntsville combined with N. Alabama LMA data and ARMOR HID algorithms [NCAR algorithm modified for application at C-band] in a testbed fashion. For lightning cessation we are revisiting the application of differential propagation phase variables for the monitoring of ice crystal alignment driven by in-cloud electric fields combined with metrics of ice water path (i.e., vertically integrated reflectivity). Importantly it should be noted that this approach is still very much a research topic and as such, we will explore operational applications that involve radar frequencies other than C-Band by using the UAH MAX X-band dual-pol radar in slow staring modes.

Petersen, W. A.↗

Dual Wavelength Lasers

Dual wavelength lasers are discussed, covering fundamental aspects on the spectroscopy and laser dynamics of these systems. Results on Tm:Ho:Er:YAG dual wavelength laser action (Ho at 2.1 m and Er at 2.9 m) as well as Nd:YAG (1.06 and 1.3 m) are presented as examples of such dual wavelength systems. Dual wavelength lasers are not common, but there are criteria that govern their behavior. Based on experimental studies demonstrating simultaneous dual wavelength lasing, some general conclusions regarding the successful operation of multi-wavelength lasers can be made.

Walsh, Brian M.↗

Proposed Flight Research of a Dual-Bell Rocket Nozzle Using the NASA F-15 Airplane

For more than a half-century, several types of altitude-compensating rocket nozzles have been proposed and analyzed, but very few have been adequately tested in a relevant flight environment. One type of altitude-compensating nozzle is the dual-bell rocket nozzle, which was first introduced into literature in 1949. Despite the performance advantages that have been predicted, both analytically and through static test data, the dual-bell nozzle has still not been adequately tested in a relevant flight environment. This paper proposes a method for conducting testing and research with a dual-bell rocket nozzle in a flight environment. We propose to leverage the existing NASA F-15 airplane and Propulsion Flight Test Fixture as the flight testbed, with the dual-bell nozzle operating during captive-carried flights, and with the nozzle subjected to a local flow field similar to that of a launch vehicle. The primary objective of this effort is not only to advance the technology readiness level of the dual-bell nozzle, but also to gain a greater understanding of the nozzle mode transitional sensitivity to local flow-field effects, and to quantify the performance benefits with this technology. The predicted performance benefits are significant, and may result in reducing the cost of delivering payloads to low-Earth orbit.

Jones, Daniel S.↗

Ultra-Wideband, Dual-Polarized, Beam-Steering P-Band Array Antenna

A dual-polarized, wide-bandwidth (200 MHz for one polarization, 100 MHz for the orthogonal polarization) antenna array at P-band was designed to be driven by NASA's EcoSAR digital beam former. EcoSAR requires two wide P-band antenna arrays mounted on the wings of an aircraft, each capable of steering its main beam up to 35deg off-boresight, allowing the twin radar beams to be steered at angles to the flight path. The science requirements are mainly for dual-polarization capability and a wide bandwidth of operation of up to 200 MHz if possible, but at least 100 MHz with high polarization port isolation and low cross-polarization. The novel design geometry can be scaled with minor modifications up to about four times higher or down to about half the current design frequencies for any application requiring a dual-polarized, wide-bandwidth steerable antenna array. EcoSAR is an airborne interferometric P-band synthetic aperture radar (SAR) research application for studying two- and three-dimensional fine-scale measurements of terrestrial ecosystem structure and biomass, which will ultimately aid in the broader study of the carbon cycle and climate change. The two 2×8 element Pband antenna arrays required by the system will be separated by a baseline of about 25 m, allowing for interferometry measurements. The wide 100-to- 200-MHz bandwidth dual-polarized beams employed will allow the determination of the amount of biomass and even tree height on the ground. To reduce the size of the patches along the boresight dimension in order to fit them into the available space, two techniques were employed. One technique is to add slots along the edges of each patch where the main electric currents are expected to flow, and the other technique is to bend the central part of the patch away from the ground plane. The latter also facilitates higher mechanical rigidity. The high port isolation of more than 40 dB was achieved by employing a highly symmetrical feed mechanism for each pair of elements: three apertures coupling to the patch elements were placed along the two symmetry lines of the antenna element pair. Two apertures were used in tandem to excite two of the stacked patch elements for one polarization; the other was used to excite one element from one side and the other element from the other side, opposite in phase, taking care of the remaining polarization. The apertures narrow down to a small gap where they are excited by a crossing microstrip line to prevent any asymmetrical excitation of the two sides of the aperture gap, minimizing port-to-port coupling. Using patches that are non-planar leads to higher mechanical rigidity and smaller patch sizes to fit into the available space. Aperture coupling minimizes direct metal-to-metal connections. Using an aperture coupling feed mechanism results in a feed network for two antenna elements with a total of three feed points, plus one simple in-phase combiner to reduce it to two ports. It greatly reduces the complexity of the alternative, but more conventional, way of feeding a pair of two dual-polarized elements with high port isolation.

duToit, Cornelis↗

Proposed Flight Research of a Dual-Bell Rocket Nozzle Using the NASA F-15 Airplane

For more than a half-century, several types of altitude-compensating rocket nozzles have been proposed and analyzed, but very few have been adequately tested in a relevant flight environment. One type of altitude-compensating nozzle is the dual-bell rocket nozzle, which was first introduced into literature in 1949. Despite the performance advantages that have been predicted, both analytically and through static test data, the dual-bell nozzle has still not been adequately tested in a relevant flight environment. This paper proposes a method for conducting testing and research with a dual-bell rocket nozzle in a flight environment. We propose to leverage the existing NASA F-15 airplane and Propulsion Flight Test Fixture as the flight testbed, with the dual-bell nozzle operating during captive-carried flights, and with the nozzle subjected to a local flow field similar to that of a launch vehicle. The primary objective of this effort is not only to advance the technology readiness level of the dual-bell nozzle, but also to gain a greater understanding of the nozzle mode transitional sensitivity to local flow-field effects, and to quantify the performance benefits with this technology. The predicted performance benefits are significant, and may result in reducing the cost of delivering payloads to low-Earth orbit.

Jones, Daniel S.↗

Brain Activations for Vestibular Stimulation and Dual Tasking Change with Spaceflight

Previous studies have documented the effects of spaceflight on human physiology and behavior, including muscle mass, cardiovascular function, gait, balance, manual motor control, and cognitive performance. An understanding of spaceflight-related changes provides important information about human adaptive plasticity and facilitates future space travel. In the current study, we evaluated how brain activations associated with vestibular stimulation and dual tasking change as a function of spaceflight. Five crewmembers were included in this study. The durations of their spaceflight missions ranged from 3 months to 7 months. All of them completed at least two preflight assessments and at least one postflight assessment. The preflight sessions occurred, on average, about 198 days and 51 days before launch; the first postflight sessions were scheduled 5 days after return. Functional MRI was acquired during vestibular stimulation and dual tasking, at each session. Vestibular stimulation was administered via skull taps delivered by a pneumatic tactile pulse system placed over the lateral cheekbones. The magnitude of brain activations for vestibular stimulation increased with spaceflight relative to the preflight levels, in frontal areas and the precuneus. In addition, longer flight duration was associated with greater preflight-to-postflight increases in vestibular activation in frontal regions. Functional MRI for finger tapping was acquired during both single-task (finger tapping only) and dual-task (simultaneously performing finger tapping and a secondary counting task) conditions. Preflight-to-post-spaceflight decreases in brain activations for dual tasking were observed in the right postcentral cortex. An association between flight duration and amplitude of flight-related change in activations for dual tasking was observed in the parietal cortex. The spaceflight-related increase in vestibular brain activations suggests that after a long-term spaceflight, more neural resources are required to process vestibular input.

Yuan, Peng↗

Physical Evaluation of GPM DPR Single- and Dual-Wavelength Algorithms

A physical evaluation of the rain profiling retrieval algorithms for the Dual-frequency Precipitation Radar (DPR) aboard the Global Precipitation Measurement (GPM) core satellite is carried out by applying them to the hydrometeor profiles generated from measured raindrop size distributions (DSD). The DSD-simulated radar profiles are used as input to the algorithms, and their estimates of hydrometeors' parameters are compared with the same quantities derived directly from the DSD data (or truth). The retrieval accuracy is assessed by the degree to which the estimates agree with the truth. To check the validity and robustness of the retrievals, the profiles are constructed for cases ranging from fully correlated (or uniform) to totally uncorrelated DSDs along the columns. Investigation into the sensitivity of the retrieval results to the model assumptions is made to characterize retrieval uncertainties and identify error sources. Comparisons between the single- and dual-wavelength algorithm performance are carried out with either a single- or dual-wavelength constraint of the path integral or differential path integral attenuation. The results suggest that the DPR dual-wavelength algorithm generally provides accurate range-profiled estimates of rainfall rate and mass-weighted diameter with the dual-wavelength estimates superior in accuracy to those from the single-wavelength retrievals.

Liang Liao↗

High Velocity Impact Performance of a Dual Layer Thermal Protection System for the Mars Sample Return Earth Entry Vehicle

The Mars Sample Return (MSR) Earth Entry Vehicle (EEV) is currently planned on being released from its Micro-Meteorite/Orbital Debri (MM/OD) shielding housing about two days before the Earth entry phase. This leaves the EEV exposed to incoming MM/OD impacts, potentially damaging the heat shield and compromising its Entry, Decent, and Landing (EDL) integrity. Currently, two materials are proposed to comprise the MSR-EEV heat shield, a dual layer material Heat-shield for Extreme Entry Environment Technology (HEEET) and Phenolic Impregnated Carbon Ablator (PICA). PICA has been well characterized for OD class impacts, ~7km/s high mass impacts, from previous testing done in the Orion program, but hasn't under-gone extensive MM impact testing. HEEET is a rela-tively new material with minimal prior testing in re-gards to High Velocity Impacts (HVI). In order to in-form selectability of a material, it is crucial to under-stand the material performance when faced with an HVI, directly affecting mission success probability.The current measure of a Thermal Protection Sys-tem's (TPS) performance against an HVI is evaluating a thermally sized material against its derived Balistic Limit Equation (BLE). A BLE is generated empirically from multiple shots of HVI testing, and is used as a first order method in evaluating TPS's performance against the expected MM/OD environment. This method has proved useful for previous uniform densi-ty TPS materials, but has never been validated against a dual layer recession material such as HEEET. Testing in the MSR program for FY19 has a re-quirement to assess the effects of a dual layer TPS by testing various thicknesses of HEEET's Recession Layer, seen in Figure 1. From this data, BLE's will be derived for the individual thickness ratio samples, as well as the material as a whole to evaluate if a heritage form of the BLE can capture the complex physics associated with a dual layer system. Crater morpholo-gy will also be assessed with post-test Non-Destructive Evaluation (NDE) methods such as CT scanning to visualize if a BLE can well predict the associated pene-tration depths, since a BLE assumes full disinigration of the impacting particle and is generally only used to size a spherical crater ? disregarding any shrapenel effects from a high density impactor.To inform this analysis, expected MM environ-ments from the Meteoroid Engineering Model (MEM) and analytical equations for mass flux of incoming MM were evaluated against the notional MSR-EEV trajectory [1]. Using those dispersions, a monte-carlo was run to determine the most probable particle pa-rameters, as well as the riskiest in terms of full bondline penetration. From these probabilities, a test matrix was designed to test against bounding cases for the various parameters of the BLE: projectile density, projectile mass, projectile velocity, and the impact angle.This presentation will discuss the performance of the dual layer TPS material HEEET against a wide range of impact kinetic energies and densitites, as well as the comparison of HEEET to PICA in terms of MM/OD performance and selectability criteria.

Libben, B. J.↗

A Second Look at 12 Candidate Dual AGNs Using BAYMAX

We present an analysis of 12 optically selected dual active galactic nucleus (AGN) candidates at z < 0.34. Each candidate was originally identified via double-peaked [O III] λ5007 emission lines and received follow-up Chandra and Hubble Space Telescope (HST) observations. Because the X-ray data are low-count (<100 counts) with small separations (<1''), a robust analysis is necessary for classifying each source. Pairing long-slit [O III] observations with existing Chandra observations, we re-analyze the X-ray observations with Bayesian AnalYsis of AGNs in X-rays to determine whether the X-ray emission from each system is more likely a single or dual point source. We find that 4 of the 12 sources are likely dual X-ray point-source systems. We examine each point source's spectra via a Monte Carlo method that probabilistically identifies the likely origin of each photon. When doing so, we find that (i) the secondary X-ray point sources in two of the systems have L(X)< 10(exp 40) erg/s, such that we cannot rule out a non-AGN origin, (ii) one source has a secondary with L(X)> 10(exp 40) erg/s but a spectrum that is too soft to definitively preclude being X-ray emitting diffuse gas that was photoionized by the primary AGN, and (iii) one system (SDSS J1126+2944) is a dual AGN. Additionally, using complementary HST observations, we analyze a subsample of systems that are visually identified as merging. Our results suggest that dual AGNs may preferentially reside in mergers with small separations, consistent with both simulations and observations.

Adi Foord↗

Dual Anion-Cation Crosslinked Poly(ionic liquid) Composite Membranes for Enhanced CO2 Separation

Herein, we propose a strategy of developing novel dual anionic-cationic crosslinked poly(IL)-IL composite membranes via a photopolymerization method for enhanced CO2 separations. These are the first examples of dually photopolymerized anionic-cationic poly(IL)-IL composite systems, in which the backbones of poly(IL)s feature both pendant anions and cations without any mobile counterions unlike poly(IL) reported so far in the literature. A new type of dual photopolymerizable anionic-cationic IL (DIL) monomer having methacrylate functional group tethered with highly delocalized sulfonimide anion (–SO2–N(-)–SO2–C7H7) and a vinylimidazolium counterion ([C4(vim)](+)) was successfully synthesized and photopolymerized with four distinct amounts of free IL with a structurally analogous cation ([C4(mim)][Tf2N]) and 20 wt% PEGDA crosslinker, offering novel composite matrices. Further, the structure-property relationships as well as gas separation behaviors of the four newly developed dual anioniccationic poly(IL)-IL composite membranes were extensively characterized by FT-IR, DSC, and XRD. All of the newly developed dual anionic-cationic poly(IL)-IL composite membranes displayed outstanding permselectivites for CO2/CH4, CO2/N2, and CO2/H2 gas pairs together with reasonable CO2 permeabilities. As a result, all the dual anionic-cationic poly(IL)-IL composite membranes outperformed the common poly(IL)-IL systems in the upper bound limit plots with best CO2 permeability of 40 barrer and CO2/CH4 permselectivity of 85. This study may pave a new platform to explore countless potential poly(IL)-IL composites for selective separation of CO2 from flue gas, natural gas, and syngas streams.

Irshad Kammakakam↗

The Precipitation Rate Retrieval Algorithms for the GPM Dual-frequency Precipitation Radar

In this paper, precipitation rate retrieval algorithms for the Global Precipitation Measurement mission's Dual-frequency Precipitation Radar (DPR) are developed. The DPR consists of a Ku-band radar (KuPR; 13.6 GHz) and a Ka-band radar (KaPR; 35.5 GHz). For the KuPR, an algorithm similar to the Tropical Rainfall Measuring Mission's Precipitation Radar algorithm is developed, with the relation between precipitation rate R and massweighted mean diameter D m (R−D m relation) replacing the relation between the specific attenuation k and effective radar reflectivity factor Z e . The R−D m relation can also be applied to the KaPR and dual-frequency algorithms. In both the single-frequency and dual-frequency algorithms, the forward retrieval method is applied with an assumed adjustment factor for the R−D m relation (ε) and the results are evaluated to select the best value of ε. The advantages of the dual-frequency algorithm are the availability of the dual-frequency surface reference technique and the ZfKa method, which is a method to use the attenuation-corrected radar reflectivity factor Z f of KaPR, to select ε as well as the possibility to selectively use measurements from KuPR or KaPR. This paper also describes the derivation of the scattering table and the R−D m relation as well as the procedure for non-uniform beam filling correction in detail. The outputs are then statistically analyzed to demonstrate algorithm performance.

precipitation radar↗

Isogeometric Bézier dual mortaring: The Kirchhoff–Love shell problem

Here in this paper we develop an isogeometric Bézier dual mortar method for coupling multi-patch Kirchhoff–Love shell structures. The proposed approach weakly enforces the continuity of the solution at patch interfaces through a dual mortar method and can be applied to both conforming and non-conforming discretizations. As the employed dual basis functions have local supports and satisfy the biorthogonality property, the resulting stiffness matrix is sparse. In addition, the coupling accuracy is optimal because the dual basis possesses the polynomial reproduction property. We also formulate the continuity constraints through the Rodrigues’ rotation operator which gives a unified framework for coupling patches that are intersected with G 1 continuity as well as patches that meet at a kink. Several linear and nonlinear examples demonstrated the performance and robustness of the proposed coupling techniques.

42 ENGINEERING↗

Expanding the Landscape of Dual Action Antifolate Antibacterials through 2,4-Diamino-1,6-dihydro-1,3,5-triazines

Antibiotics that operate via multiple mechanisms of action are a promising strategy to combat growing resistance. Previous studies have shown that dual action antifolates formed from a pyrroloquinazolinediamine core can inhibit the growth of bacterial pathogens without developing resistance. Here, in this work, we expand the scope of dual action antifolates by repurposing the 2,4-diamino-1,6-dihydro-1,3,5-triazine (DADHT) cycloguanil scaffold to a variety of derivatives designed to inhibit dihydrofolate reductase (DHFR) and disrupt bacterial membranes. Dual mechanism DADHTs have activity against a variety of target pathogens, including Mycobacterium tuberculosis, Mycobacterium abscessus, and Pseudomonas aeruginosa, among other ESKAPEE organisms. Through X-ray crystallography, we confirmed engagement of the Escherichia coli DHFR target and found that some DADHTs stabilize a previously unobserved conformation of the enzyme but, broadly, bind in the occluded conformation. Using in vitro inhibition of purified E. coli and Staphylococcus aureus DHFR and disruption of E. coli membranes, we determined that alkyl substitution of dihydrotriazine at the 6-position best optimizes the DADHT's two mechanisms of action. By employing both mechanisms, the DADHT spectrum of activity was extended beyond the scope of traditional antifolates. Finally, we are optimistic that the dual mechanism approach, particularly through the action of antifolates, offers a unique means of combating hard-to-treat bacterial infections.

60 APPLIED LIFE SCIENCES↗

An Initial Assessment of the Surface Reference Technique Applied to Data from the Dual-Frequency Precipitation Radar (DPR) on the GPM Satellite

It has long been recognized that path-integrated attenuation (PIA) can be used to improve precipitation estimates from high-frequency weather radar data. One approach that provides an estimate of this quantity from airborne or spaceborne radar data is the surface reference technique (SRT), which uses measurements of the surface cross section in the presence and absence of precipitation. Measurements from the dual-frequency precipitation radar (DPR) on the Global Precipitation Measurement (GPM) satellite afford the first opportunity to test the method for spaceborne radar data at Ka band as well as for the Ku-band-Ka-band combination. The study begins by reviewing the basis of the single- and dual-frequency SRT. As the performance of the method is closely tied to the behavior of the normalized radar cross section (NRCS or sigma(0)) of the surface, the statistics of sigma(0) derived from DPR measurements are given as a function of incidence angle and frequency for ocean and land backgrounds over a 1-month period. Several independent estimates of the PIA, formed by means of different surface reference datasets, can be used to test the consistency of the method since, in the absence of error, the estimates should be identical. Along with theoretical considerations, the comparisons provide an initial assessment of the performance of the single- and dual-frequency SRT for the DPR. The study finds that the dual-frequency SRT can provide improvement in the accuracy of path attenuation estimates relative to the single-frequency method, particularly at Ku band.

space-borne weather radars↗

System Resilience Benefits of Dual-Fuel Capable Generators

The growing dependency on natural gas (NG) for power generation raises challenges for ensuring the resilience of power systems during extreme cold weather. Dual-fuel capable generators that can switch from burning NG to distillate fuel oil during an NG shortage over one way to alleviate these challenges. In this study, the impacts of gas unavailability on the IEEE 73-bus reliability test system (RTS) with 2019 updated generation mixture are explored. An extension to the standard production cost model formulation of unit commitment and economic dispatch is proposed to allow the representation of dual-fuel capable generators that can switch fuels between NG and distillate oil with a specified oil tank capacity and tank refueling capability. The operation of the system under gas unavailability with 0%, 25%, 50%, 75%, and 100% of combined cycle and combustion turbine generators as dual-fuel capable with a one-day supply of fuel oil are simulated using PLEXOS, a production cost model. The dual-fuel generator performance, unserved energy, and system costs are fully assessed.

dual-fuel capable generator↗