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All sourcesNASA NTRSDOE OSTI
NASA NTRSDate not supplied

Magma-Sediment Interaction Induced Alteration Mineralogy on Mars: Detectability and Analytical Method Comparison Using the Curtis Sandstone as A Terrestrial Analog

Basaltic magmatism is a ubiquitous feature of the Martian crust, and would have interacted with sediments and fluids through the geologic history of Mars to potentially produce higher temperature hydrothermal systems , and contact metamorphic rocks. On Earth, comparable hydrothermal systems represent habitable environments, which can be used as an analog for Mars. Nevertheless, evidence of aforementioned hydrothermal systems on Mars has remained elusive, despite the efforts of both orbital and in-situ analyses. Limited low grade metamorphic minerals typically indicative of hydrothermal systems (prehnite, zeolites, serpentine) have been detected in the Martian crust, though the detections are typically isolated occurrences, and do not necessarily indicate an in-place metamorphic sequence. It is possible that orbital spectroscopy alone is not capable of detecting such an alteration front, with higher resolution in-situ analyses being required to detect the changes in mineralogy and species of alteration minerals associated with magma-sediment interaction. To constrain this, we have investigated a terrestrial analog on the Colorado Plateau, USA, where a mafic dike intrudes a quartz areinite of the Jurassic Curtis Sandstone. The investigation was carried out using Mars relevant instruments: Visible to Near-Infrared (VNIR) spectroscopy analogous to orbital spectroscopy, and X-ray Diffraction (XRD) analogous to CheMin on Mars Sample Laboratory Curiosity. While quartz sandstones have not been, and are unlikely to be, detected on Mars, the relatively mineralogically uniform Curtis Sandstone serves as analog here as it avoids complications of multiple mineral systems or significant element exchange with the surrounding area.

J R Crandall↗
DOE OSTI2024

Window-integrated charge-mode digital-to-analog converter for arbitrary waveform generator

A digital-to-analog converter circuit that creates an analog waveform from an input digital waveform. Operating the circuit comprises using the input digital waveform to 1) operate a charge control switch to set a charge time period, 2) operate a discharge control switch to set a discharge time period, 3) set a charge current magnitude using a charge gain, and 4) set a discharge current magnitude using a discharge gain. A charge source electrically charges a load capacitor during the charge time period (i.e., the charge mode). A discharge source electrically discharges the load capacitor during the discharge time period (i.e., the discharge mode). A circuit output transmits the analog waveform defined by the charge mode and the discharge mode. A charge current magnitude greater than the discharge current magnitude produces an upward-sloping analog waveform. A charge current magnitude less than the discharge current magnitude produces a downward-sloping analog waveform.

Li, Shaorui↗
DOE OSTI2014

High density, multi-range analog output Versa Module Europa board for control system applications

A new VMEDAC64, 12-bit 64 channel digital-to-analog converter, a Versa Module Europa (VME) module, features 64 analog voltage outputs with user selectable multiple ranges, has been developed for control system applications at Inter University Accelerator Centre. The FPGA (Field Programmable Gate Array) is the module's core, i.e., it implements the DAC control logic and complexity of VMEbus slave interface logic. The VMEbus slave interface and DAC control logic are completely designed and implemented on a single FPGA chip to achieve high density of 64 channels in a single width VME module and will reduce the module count in the control system applications, and hence will reduce the power consumption and cost of overall system. One of our early design goals was to develop the VME interface such that it can be easily integrated with the peripheral devices and satisfy the timing specifications of VME standard. The modular design of this module reduces the amount of time required to develop other custom modules for control system. The VME slave interface is written as a single component inside FPGA which will be used as a basic building block for any VMEbus interface project. The module offers multiple output voltage ranges depending upon the requirement. The output voltage range can be reduced or expanded by writing range selection bits in the control register. The module has programmable refresh rate and by default hold capacitors in the sample and hold circuit for each channel are charged periodically every 7.040 ms (i.e., update frequency 284 Hz). Each channel has software controlled output switch which disconnects analog output from the field. The modularity in the firmware design on FPGA makes the debugging very easy. On-board DC/DC converters are incorporated for isolated power supply for the analog section of the board.

46 INSTRUMENTATION RELATED TO NUCLEAR SCIENCE AND ↗
DOE OSTI2025

Nonlinear analog processing with anisotropic nonlinear films

Digital signal processing is the cornerstone of several modern-day technologies, yet in multiple applications it faces critical bottlenecks related to memory and speed constraints. Thanks to recent advances in metasurface design and fabrication, light-based analog computing has emerged as a viable option to partially replace or augment digital approaches. Several light-based analog computing functionalities have been demonstrated using patterned flat optical elements, with great opportunities for integration in compact nanophotonic systems. So far, however, the available operations have been restricted to the linear regime, limiting the impact of this technology to a compactification of Fourier optics systems. In this paper, we introduce nonlinear operations to the field of metasurface-based analog optical processing, demonstrating that nonlinear optical phenomena, combined with nonlocality in flat optics, can be leveraged to synthesize kernels beyond linear Fourier optics, paving the way to a broad range of new opportunities. As a practical demonstration, we report the experimental synthesis of a class of nonlinear operations that can be used to realize broadband, polarization-selective analog-domain edge detection.

analog image processing↗
DOE OSTI2018

Crystal Structure of CYP2B6 in Complex with an Efavirenz Analog

The over two dozen CYP2B structures of human, rabbit, and woodrat enzymes solved in the last decade have significantly enhanced our understanding of the structure-function relationships of drug metabolizing enzymes. More recently, an important role has emerged for halogen-π interactions in the CYP2B6 active site in substrate selectivity, explaining in part the preference for halogenated ligands as substrates. The mechanism by which such ligands interact with CYP2B enzymes involves conserved phenylalanine side chains, in particular F108, F115, or F297, in the active site, which form π bonds with halogens. To illustrate such halogen-π interactions using drugs that are major substrates of CYP2B6, we present here a crystal structure of CYP2B6 in complex with an analog of the widely used anti-HIV drug efavirenz, which contains a methyl group in place of the carbonyl oxygen. The chlorine of the efavirenz analog forms a π bond with the aromatic ring of F108, whereas the putative metabolism site on the distal end of the molecule is oriented towards the heme iron. The crystal structure showcases how CYP2B6 accommodates this important drug analog of considerable size in the active site by movement of various side chains without substantially increasing the active site volume. Furthermore, the CYP2B6-efavirenz analog complex provides a useful platform to investigate computationally as well as biophysically the effect of genetic polymorphisms on binding of the widely studied efavirenz.

37 INORGANIC, ORGANIC, PHYSICAL, AND ANALYTICAL CH↗
NASA NTRS2013

Terrestrial Analog Field Investigations to Enable Science and Exploration Studies of Impacts and Volcanism on the Moon, NEAs, and Moons of Mars

Terrestrial analog studies are a critical component for furthering our understanding of geologic processes on the Moon, near-Earth asteroids (NEAs), and the moons of Mars. Carefully chosen analog sites provide a unique natural laboratory with high relevance to the associated science on these solar system target bodies. Volcanism and impact cratering are fundamental processes on the Moon, NEAs, and Phobos and Deimos. The terrestrial volcanic and impact records remain invaluable for our understanding of these processes throughout our solar system, since these are our primary source of firsthand knowledge on volcanic landform formation and modification as well as the three-dimensional structural and lithological character of impact craters. Regarding impact cratering, terrestrial fieldwork can help us to understand the origin and emplacement of impactites, the history of impact bombardment in the inner Solar System, the formation of complex impact craters, and the effects of shock on planetary materials. Volcanism is another dominant geologic process that has significantly shaped the surface of planetary bodies and many asteroids. Through terrestrial field investigations we can study the processes, geomorphic features and rock types related to fissure eruptions, volcanic constructs, lava tubes, flows and pyroclastic deposits. Also, terrestrial analog studies have the advantage of enabling simultaneous robotic and/or human exploration testing in a low cost, low risk, high fidelity environment to test technologies and concepts of operations for future missions to the target bodies. Of particular interest is the importance and role of robotic precursor missions prior to human operations for which there is little to no actual mission experience to draw upon. Also critical to understanding new worlds is sample return, and analog studies enable us to develop the appropriate procedures for collecting samples in a manner that will best achieve the science objectives.

complex impact craters↗
NASA NTRS2011

The Mojave Desert: A Martian Analog Site for Future Astrobiology Themed Missions

Astrobiological interest in Mars is highlighted by evidence that Mars was once warm enough to have liquid water present on its surface long enough to create geologic formations that could only exist in the presense of extended fluvial periods. These periods existed at the same time life on Earth arose. If life began on Mars as well during this period, it is reasonable to assume it may have adapted to the subsurface as environments at the surface changed into the inhospitable state we find today. If the next series of Mars missions (Mars Science Laboratory, the ExoMars Trace Gas Orbiter proposed for launch in 2016, and potential near surface sample return) fail to discover either extinct or extant life on Mars, a subsurface mission would be necessary to attempt to "close the book" on the existence of martian life. Mars is much colder and drier than Earth, with a very low pressure CO2 environment and no obvious habitats. Terrestrial regions with limited precipitation, and hence reduced active biota, are some of the best martian low to mid latitude analogs to be found on Earth, be they the Antarctic dry valleys, the Atacama or Mojave Deserts. The Mojave Desert/Death Valley region is considered a Mars analog site by the Terrestrial Analogs Panel of the NSF-sponsored decadal survey; a field guide was even developed and a workshop was held on its applicability as a Mars analog. This region has received a great deal of attention due to its accessibility and the variety of landforms and processes observed relevant to martian studies.

Mars analog sites↗
NASA NTRSDate not supplied

On the Importance of Producing and Characterizing Laboratory Analogs of Cosmic Grains, Planetary Atmospheric Aerosols, and Surface Materials

Carbonaceous dust and aerosols have been observed in interstellar/circumstellar and planetary environments. Dedicated laboratory experiments have been developed to produce analogs of these solid materials under different experimental conditions (molecular precursors, temperature, pressure, energy source…). These experimental studies are key to investigating the physical and chemical processes that drive the formation of solid particles from gas and solid phase molecular precursors in astrophysical and planetary environments. They also allow the characterization of the physical, optical, and chemical properties of these laboratory-generated analogs, hence providing critical information that can be used as input parameters in models for the analysis and interpretation of observational data. Here, as an example of these laboratory efforts, we will present various studies that combined (1) experiments performed with the NASA Ames COSmIC facility to produce analogs of Titan’s atmospheric aerosols and cosmic grains from gas phase molecular precursors, and (2) the characterization of these analogs with the NASA Ames Optical Constants Facility (OCF) to provide the real and imaginary parts of their refractive indices, n + ik, to the community, from the visible to the far-infrared (0.59–200 µm, 16,950–50 per cm). We will also discuss the importance of the wavelength and spectral range coverage of these optical constants, n and k, for their use in radiative transfer, atmospheric and reflectance models, and present a new effort to develop an Optical Constant database (OCdb) to provide this critical data to the scientific community.

Cosmic Grains↗
NASA NTRSDate not supplied

Standard measures in Analogs of Spaceflight

Standard measures are defined as research measures (physiological, performance, or otherwise) that quantify the subject’s health and performance before, during, and after a spaceflight or a spaceflight analog mission. The Standard Measures Cross-Cutting Project (SMCCP) collects and analyzes standard measures that support assessment and quantification of health risks and efficacy of countermeasures and technologies required to prevent or mitigate adverse outcomes from exposure to the spaceflight environment. SMCCP uses the following spaceflight analogs: - Human Exploration Research Analog (HERA) in Houston, TX: 4-person isolation/confinement; nominal mission duration of 45 days; run by the Human Research Program (HRP). SMCCP uses weekly questionnaires to gather data on the crewmembers’ emotional and mental state and collects blood samples biweekly to measure crewmembers’ serum cortisol levels at the start, middle, and end of the mission. - Institute for Biomedical Problems (IBMP) Ground-Based Experimental Complex, called NEK, in Moscow, Russia: 6-person isolation/confinement; duration of 8 months; run by IBMP. Standard measures data collected during NEK are the same as for HERA above. - :envihab in Cologne, Germany: 12-person bed rest facility; closed environment; 30 to 60-day campaigns; run by the German Aerospace Center (DLR). For bedrest studies, SMCCP uses the international standard measures as documented in the International Academy of Astronautics publication titled Guidelines for Standardization of Bed Rest Studies in the Spaceflight Context (June 2014). These international standard measures evaluate potential changes in bone, muscle, cardiovascular, and visual systems, as well as changes in psychology and nutrition. The international standard measures complement those collected during studies by individual investigators and allow comparison of responses across different bed rest and countermeasures durations. In this presentation, we will review available SMCCP data collected during the recent isolation studies in HERA (C6) and NEK (SIRIUS-21), and during the SANS (SM1, SM2) bed rest studies in :envihab. These standard measures datasets are made available to concurrent investigators in the given mission or campaign via data sharing agreements and/or data sharing plans and to other investigators that have been granted retrospective access to the data (researchers with IRB approved protocols, risk custodians) to advance understanding of physiological and behavioral risks associated with these spaceflight analogs.

Standard Measures↗
DOE OSTI2017

Comparison of Mutual Awareness in Analog vs. Digital Control Rooms

Control rooms in nuclear power plants are complex, collaborative working environments rife with potential for human error. As control rooms evolve from analog to digital interface environments, crew communication strategies must change as well. Operators in the analog control room operate the plant and communicate with each other with the help of control boards with large control panels, meters, and switches. Reactor operators could choose a particular set of controls on the particular control board which corresponds to the part of the system of interest. Visual display units (VDU), which became a fixture in the control rooms with the shift to digital human-machine interfaces (HMI), bring benefits for safety and flexibility combining information from various sources. With the increase in automation and the use of digital HMIs operators received their personal sitting workstations where they are able to navigate and operate the plant. The amount of information increased as well as the complexity of monitoring and analyzing the system states. Also computerized systems cause operators to get absorbed by their personal screens and reduce interaction between the crew members. Therefore, the collaboration and coordination of task demands requires vigilance and mutual awareness. The level of automation has an influence on the level of mutual awareness experienced by operators in the control rooms. Teams function to carry out highly interdependent tasks, requiring synthesis and sharing of information to achieve common goals. Improving the performance of the team necessitates the operators to focus on the system, the surrounding environment, and situational awareness about the system states. Collaboration of team members is critical when employing the digital operating systems as the acute awareness of the overall progress of the group and individual activities of the operators drives the team to the desired end-states of the plant operations. Out-of-the loop (OOTL) performance problems can be referred to as the lack of supervisory control, system monitoring, and information processing in the digital HMIs. Under some circumstances Senior Reactor Operators (SRO) struggle to follow the actions of other Reactor Operators (RO) because with the new digital interfaces SROs lose track of how the procedures are carried out by ROs, which results in the loss of three way communication. Mutual awareness plays a significant role in keeping the SROs in the loop of plant operations. This paper will investigate, through literature review and expert interviews, the impact and human errors attributed to the increasing complexity of new digital main control rooms. Comparison of the new digital interfaces with the analog interfaces in nuclear power plants has the potential to shed light on increasing mutual awareness and three way communications between the SROs and ROs. Further, identification of the human errors and human actions can provide beneficial information, suggesting significant and critical improvements that can be implemented in the main control rooms to increase safety and reliability of new technology. Additionally, insights on mutual awareness for analog vs. digital control rooms can serve to improve human reliability.

99 GENERAL AND MISCELLANEOUS↗
DOE OSTI2013

An analog model for quantum lightcone fluctuations in nonlinear optics

We propose an analog model for quantum gravity effects using nonlinear dielectrics. Fluctuations of the spacetime lightcone are expected in quantum gravity, leading to variations in the flight times of pulses. This effect can also arise in a nonlinear material. We propose a model in which fluctuations of a background electric field, such as that produced by a squeezed photon state, can cause fluctuations in the effective lightcone for probe pulses. This leads to a variation in flight times analogous to that in quantum gravity. We make some numerical estimates which suggest that the effect might be large enough to be observable. - Highlights: Black-Right-Pointing-Pointer Lightcone fluctuations, quantum fluctuations of the effective speed of light, are a feature of quantum gravity. Black-Right-Pointing-Pointer Nonlinear dielectrics have a variable speed of light, analogous to the effects of gravity. Black-Right-Pointing-Pointer Fluctuating electric fields create the effect of lightcone fluctuations in a nonlinear material. Black-Right-Pointing-Pointer We propose to use squeezed light in a nonlinear material as an analog model of lightcone fluctuations. Black-Right-Pointing-Pointer Variation in the speed of propagation of pulses is the observational signature of lightcone fluctuations.

79 ASTRONOMY AND ASTROPHYSICS↗
DOE OSTI2016

4-(E)-{(p-tolylimino)-methylbenzene-1,2-diol}, 1 a novel resveratrol analog, differentially regulates estrogen receptors α and β in breast cancer cells

Breast cancer is a public health concern worldwide. Prolonged exposure to estrogens has been implicated in the development of breast neoplasms. Epidemiologic and experimental evidence suggest a chemopreventive role of phytoestrogens in breast cancers. Resveratrol, a naturally occurring phytoestrogen, has been shown to have potent anti-cancer properties. However, poor efficacy and bioavailability have prevented the use of resveratrol in clinics. In order to address these problems, we have synthesized a combinatorial library of azaresveratrol analogs and tested them for their ability to inhibit the proliferation of breast cancer cells. We have recently shown that 4-(E)-{(p-tolylimino)-methylbenzene-1,2-diol} (TIMBD), has better anti-cancer properties than resveratrol and any other resveratrol analog we have synthesized so far. The objective of this study was to investigate the regulation of estrogen receptors (ERs) α and β by TIMBD in breast cancer cell lines. We demonstrate that TIMBD significantly induces the mRNA and protein expression levels of ERβ and inhibits that of ERα. TIMBD inhibits mRNA and protein expression levels of oncogene c-Myc, and cell cycle protein cyclin D1, which are important regulators of cellular proliferation. TIMBD significantly induces protein expression levels of tumor suppressor genes p53 and p21 in MCF-7 cells. TIMBD inhibits c-Myc in an ERβ-dependent fashion in MCF-10 A and ERβ1-transfected MDA-MB-231 cells, suggesting regulation of ERs as an important upstream mechanism of this analog. ERβ plays a partial role in inhibition of proliferation by TIMBD while ERα overexpression does not significantly affect TIMBD's inhibition. - Highlights: • Resveratrol analog TIMBD inhibits growth of breast cancer cells. • TIMBD induces protein expression levels of ERβ and inhibits that of ERα. • TIMBD inhibits c-Myc and cyclin D1, and induces p53 and p21. • TIMBD suppresses c-Myc in an ER-dependent fashion.

60 APPLIED LIFE SCIENCES↗
DOE OSTI2021

GHB analogs confer neuroprotection through specific interaction with the CaMKIIα hub domain

Ca 2+ /calmodulin-dependent protein kinase II alpha subunit (CaMKIIα) is a key neuronal signaling protein and an emerging drug target. The central hub domain regulates the activity of CaMKIIα by organizing the holoenzyme complex into functional oligomers, yet pharmacological modulation of the hub domain has never been demonstrated. Here, using a combination of photoaffinity labeling and chemical proteomics, we show that compounds related to the natural substance γ-hydroxybutyrate (GHB) bind selectively to CaMKIIα. By means of a 2.2-Å x-ray crystal structure of ligand-bound CaMKIIα hub, we reveal the molecular details of the binding site deep within the hub. Furthermore, we show that binding of GHB and related analogs to this site promotes concentration-dependent increases in hub thermal stability believed to alter holoenzyme functionality. Selectively under states of pathological CaMKIIα activation, hub ligands provide a significant and sustained neuroprotection, which is both time and dose dependent. This is demonstrated in neurons exposed to excitotoxicity and in a mouse model of cerebral ischemia with the selective GHB analog, HOCPCA (3-hydroxycyclopent-1-enecarboxylic acid). Together, our results indicate a hitherto unknown mechanism for neuroprotection by a highly specific and unforeseen interaction between the CaMKIIα hub domain and small molecule brain-penetrant GHB analogs. This establishes GHB analogs as powerful tools for investigating CaMKII neuropharmacology in general and as potential therapeutic compounds for cerebral ischemia in particular.

59 BASIC BIOLOGICAL SCIENCES↗
DOE OSTI2013

FINDING {eta} CAR ANALOGS IN NEARBY GALAXIES USING SPITZER. I. CANDIDATE SELECTION

The late-stage evolution of the most massive stars such as {eta} Carinae is controlled by the effects of mass loss, which may be dominated by poorly understood eruptive mass ejections. Understanding this population is challenging because no true analogs of {eta} Car have been clearly identified in the Milky Way or other galaxies. We utilize Spitzer IRAC images of seven nearby ({approx}< 4 Mpc) galaxies to search for such analogs. We find 34 candidates with a flat or rising mid-IR spectral energy distributions toward longer mid-infrared wavelengths that emit >10{sup 5} L{sub Sun} in the IRAC bands (3.6 to 8.0 {mu}m) and are not known to be background sources. Based on our estimates for the expected number of background sources, we expect that follow-up observations will show that most of these candidates are not dust enshrouded massive stars, with an expectation of only 6 {+-} 6 surviving candidates. Since we would detect true analogs of {eta} Car for roughly 200 years post-eruption, this implies that the rate of eruptions like {eta} Car is less than the core-collapse supernova rate. It is possible, however, that every M > 40 M{sub Sun} star undergoes such eruptions given our initial results. In Paper II we will characterize the candidates through further analysis and follow-up observations, and there is no barrier to increasing the galaxy sample by an order of magnitude. The primary limitation of the present search is that Spitzer's resolution limits us to the shorter wavelength IRAC bands. With the James Webb Space Telescope, such surveys can be carried out at the far more optimal wavelengths of 10-30 {mu}m, allowing identification of {eta} Car analogs for millennia rather than centuries post-eruption.

79 ASTRONOMY AND ASTROPHYSICS↗
DOE OSTI2015

X-ray insights into the nature of PHL 1811 analogs and weak emission-line quasars: Unification with a geometrically thick accretion disk?

We present an X-ray and multiwavelength study of 33 weak emission-line quasars (WLQs) and 18 quasars that are analogs of the extreme WLQ, PHL 1811, at z≈0.5–2.9. New Chandra 1.5–9.5 ks exploratory observations were obtained for 32 objects while the others have archival X-ray observations. Significant fractions of these luminous type 1 quasars are distinctly X-ray weak compared to typical quasars, including 16 (48%) of the WLQs and 17 (94%) of the PHL 1811 analogs with average X-ray weakness factors of 17 and 39, respectively. We measure a relatively hard (Γ=1.16{sub −0.32}{sup +0.37}) effective power-law photon index for a stack of the X-ray weak subsample, suggesting X-ray absorption, and spectral analysis of one PHL 1811 analog, J1521+5202, also indicates significant intrinsic X-ray absorption. We compare composite Sloan Digital Sky Survey spectra for the X-ray weak and X-ray normal populations and find several optical–UV tracers of X-ray weakness, e.g., Fe ii rest-frame equivalent width (REW) and relative color. We describe how orientation effects under our previously proposed “shielding-gas” scenario can likely unify the X-ray weak and X-ray normal populations. We suggest that the shielding gas may naturally be understood as a geometrically thick inner accretion disk that shields the broad line region from the ionizing continuum. If WLQs and PHL 1811 analogs have very high Eddington ratios, the inner disk could be significantly puffed up (e.g., a slim disk). Shielding of the broad emission-line region by a geometrically thick disk may have a significant role in setting the broad distributions of C iv REW and blueshift for quasars more generally.

79 ASTRONOMY AND ASTROPHYSICS↗
DOE OSTI2014

ON THE FREQUENCY OF POTENTIAL VENUS ANALOGS FROM KEPLER DATA

The field of exoplanetary science has seen a dramatic improvement in sensitivity to terrestrial planets over recent years. Such discoveries have been a key feature of results from the Kepler mission which utilizes the transit method to determine the size of the planet. These discoveries have resulted in a corresponding interest in the topic of the Habitable Zone and the search for potential Earth analogs. Within the solar system, there is a clear dichotomy between Venus and Earth in terms of atmospheric evolution, likely the result of the large difference (approximately a factor of two) in incident flux from the Sun. Since Venus is 95% of the Earth's radius in size, it is impossible to distinguish between these two planets based only on size. In this Letter we discuss planetary insolation in the context of atmospheric erosion and runaway greenhouse limits for planets similar to Venus. We define a ''Venus Zone'' in which the planet is more likely to be a Venus analog rather than an Earth analog. We identify 43 potential Venus analogs with an occurrence rate (η{sub ♀}) of 0.32{sub −0.07}{sup +0.05} and 0.45{sub −0.09}{sup +0.06} for M dwarfs and GK dwarfs, respectively.

79 ASTRONOMY AND ASTROPHYSICS↗
DOE OSTI2020

Digital-analog quantum computation

Digital quantum computing paradigm offers highly desirable features such as universality, scalability, and quantum error correction. However, physical resource requirements to implement useful error-corrected quantum algorithms are prohibitive in the current era of NISQ devices. As an alternative path to performing universal quantum computation, within the NISQ era limitations, we propose to merge digital single-qubit operations with analog multiqubit entangling blocks in an approach we call digital-analog quantum computing (DAQC). Along these lines, although the techniques may be extended to any resource, we propose to use unitaries generated by the ubiquitous Ising Hamiltonian for the analog entangling block and we prove its universal character. Here, we construct explicit DAQC protocols for efficient simulations of arbitrary inhomogeneous Ising, two-body, and M-body spin Hamiltonian dynamics by means of single-qubit gates and a fixed homogeneous Ising Hamiltonian. Additionally, we compare a sequential approach where the interactions are switched on and off (stepwise DAQC) with an always-on multiqubit interaction interspersed by fast single-qubit pulses (banged DAQC). Finally, we perform numerical tests comparing purely digital schemes with DAQC protocols, showing a remarkably better performance of the latter. The proposed DAQC approach combines the robustness of analog quantum computing with the flexibility of digital methods.

97 MATHEMATICS AND COMPUTING↗
DOE OSTI2016

SU-G-201-06: Directional Low-Dose Rate Brachytherapy: Determination of the TG-43 Dose-Rate Constant Analog for a New Pd-103 Source

Purpose: The aim of this work is to determine the TG-43 dose-rate constant analog for a new directional low-dose rate brachytherapy source based on experimental methods and comparison to Monte Carlo simulations. The CivaSheet™ is a new commercially available planar source array comprised of a variable number of discrete directional source elements called “CivaDots”. Given the directional nature and non-conventional design of the source, modifications to the AAPM TG-43 protocol for dosimetry are required. As a result, various parameters of the TG-43 dosimetric formalism have to be adapted to accommodate this source. This work focuses on the dose-rate constant analog determination for a CivaDot. Methods: Dose to water measurements of the CivaDot were performed in a polymethyl methacrylate phantom (20×20×12 cm{sup 3}) using thermoluminescent dosimeters (TLDs) and Gafchromic EBT3 film. The source was placed in the center of the phantom, and nine TLD micro-cubes were irradiated along its central axis at a distance of 1 cm. For the film measurements, the TLDs were substituted by a (3×3) cm{sup 2} EBT3 film. Primary air-kerma strength measurements of the source were performed using a variable-aperture free-air chamber. Finally, the source was modeled using the Monte Carlo N-Particle Transport Code 6. Results: Dose-rate constant analog observed for a total of eight CivaDots using TLDs and five CivaDots using EBT3 film was within ±7.0% and ±2.9% of the Monte Carlo predicted value respectively. The average difference observed was −4.8% and −0.1% with a standard deviation of 1.7% and 2.1% for the TLD and the film measurements respectively, which are both within the comparison uncertainty. Conclusion: A preliminary investigation to determine the doserate constant analog for a CivaDot was conducted successfully with good agreement between experimental and Monte Carlo based methods. This work will aid in the eventual realization of a clinically-viable dosimetric framework for the CivaSheet. This work was partially supported by NCI contract (HHSN261201200052C) through CivaTech Oncology Inc.

60 APPLIED LIFE SCIENCES↗