Engineering Papers⌕ Search

SEARCH · Engineering Papers

Results for “target tracking”

Search indexed NASA NTRS and DOE OSTI research on propulsion, heat transfer, battery materials and energy systems. Follow report and document links to the original sources.

Quote a phrase for an exact phrase match. Source license links do not imply unrestricted reuse.

At least 1,423 records · Page 79

The International Space Station Supports International Polar Year (IPY)

Every day, ISS astronauts photograph designated sites and dynamic events on the Earth's surface using digital cameras equipped with a variety of lenses. Depending on observation parameters, astronauts can collect high resolution (4-6 m pixel size) or synoptic views (lower resolution but covering very large areas) digital data in 3 (red-green-blue) color bands. ISS crews have daily opportunities to document a variety of high-latitude phenomena. Although lighting conditions, ground track and other viewing parameters change with orbital precessions and season, the 51.6o orbital inclination and 400 km altitude of the ISS provide the crew an unique vantage point for collecting image-based data of polar phenomena, including surface observations to roughly 65o latitude, and upper atmospheric observations that reach nearly to the poles. During the 2007-2009 timeframe of the IPY, polar observations will become a scientific focus for the CEO experiment; the experiment is designated ISS-IPY. We solicit requests from scientists for observations from the ISS that are coordinated with or complement ground-based polar studies. The CEO imagery website for ISS-IPY provides an on-line form that allows IPY investigators to interact with CEO scientists and define their imagery requests. This information is integrated into daily communications with the ISS astronauts about their Earth Observations targets. All data collected are cataloged and posted on the website for downloading and assimilation into IPY projects. Examples of imagery and detailed information about scientific observations from the ISS can also be downloaded from the ISS-IPY web site.

Evans, Cynthia A.↗

Mars Optimal Aerobrake Maneuver Estimation

Mars science satellites often perform orbit changes to obtain different measurements, ground tracks or relay operations. Large reductions in semi-major axis and eccentricity can be done efficiently using the atmospheric drag, a.k.a aerobrake. Aerobraking is one of the most challenging planetary orbit maneuvers in terms of planning and operations. The most important consideration for aerobraking is maintaining the spacecraft's periapsis within an allocated atmospheric density corridor, which is accomplished by raising or lowering periapsis through one or a series of very small and short maneuvers. These maneuvers must be performed as efficiently as possible due to propellant constraints. Work herein details a fast and accurate method to calculate the required impulsive velocity changes in the orbit to guarantee that the spacecraft remains in a prescribed density corridor. The method makes use of the orbit's state transition matrix to map the solution space around the reference orbit. It evaluates the most efficient maneuver epochs to target a given periapsis change with a linear optimal control for single or multiple maneuvers. A fast calculation of the maneuver allows for a more comprehensive evaluation of the trade space, and the selected maneuver may be re-targeted later with a higher- fidelity model. Comparisons against fully propagated models and direct method optimizations demonstrate the new method's performance.

Sarli, Bruno V.↗

A hardware-in-the-loop (HIL) testbed for cyber-physical energy systems in smart commercial buildings

In recent years, there has been a growing trend toward the development of smart buildings that rely on cyber-physical systems (CPS) to optimize occupant comfort, safety, and energy efficiency. To ensure the reliable and efficient operation of CPS with designed control strategies, it is important to evaluate their performance under various scenarios before deploying them in the real world. This is where a Hardware-in-the-loop (HIL) testbed designed for studying sensor and control-related studies in smart buildings can be highly valuable. With the growing threat of cyber-attacks and physical faults targeting smart buildings, it is essential to ensure the security of building operations. A HIL testbed can emulate cyber-attack and physical fault scenarios, allowing researchers to develop and test threat detection and mitigation algorithms. This enables researchers to identify potential issues and optimize the algorithms in a safe and controlled environment before they are deployed in real-world settings, reducing the risk of failures that can negatively impact occupant comfort, safety, and energy efficiency. Therefore, this paper developed a HIL testbed designed for cyber-physical energy systems (e.g. buildings automation system (BAS)) in smart commercial buildings. The HIL testbed is comprised of a real-time building and Heating, Ventilation, and Air-Conditioning (HVAC) emulator using Modelica-based dynamic models, a set of BAS controllers, and a BAS computer server. The data generation capability of the HIL testbed is demonstrated by tracking normal and faulty operating data in the BAS, as well as monitoring detailed network traffic in the local BAS network. Here, this study further demonstrates the HIL testbed’s capability by conducting case studies on real-time physical fault and cyber-attack experiments using a Department of Energy (DOE) prototype commercial building. It is anticipated that the fully functional HIL testbed will be utilized for a variety of sensor and control-related studies, including but not limited to testing, developing, validating of different HVAC control strategies, fault detection & diagnosis, energy monitoring and analysis, cyber security study, etc.

32 ENERGY CONSERVATION, CONSUMPTION, AND UTILIZATI↗

Machine Learning based Aircraft Performance Model Estimation for Trajectory Prediction

The accurate prediction of aircraft trajectory by ground-based decision support tools is a critical component of air traffic management in the US National Airspace System (NAS). Accurate predictions of where the aircraft will be in the future or when they will arrive at specific locations (e.g., fixes) is a key enabler for sequencing and efficient arrival management of flights. Traditional physics based aircraft trajectory prediction relies on a simplified point-mass total energy model whose parameters are referred to as Aircraft Performance Model (APM) parameters. Even though the performance coefficients and weight of an aircraft are a vital part of the aircraft performance model’s predictions and accuracy, these coefficients are proprietary in nature and therefore, unavailable to decision-support tools. Current approaches freeze some coefficients to default base of aircraft data (BADA) values and optimize others. However, the APM parameters are highly coupled by the flight dynamics and prioritizing one parameter over others leads to bias and skewed predictions. To alleviate this problem, we provide a combined optimization framework to predict all the critical (thrust, drag and weight) APM parameters. This paper is focused on training Machine Learning (ML) models that map historical flights to optimized APM parameters that provide the best fit (in terms of prediction error). Our dataset obtained from NASA’s Sherlock data warehouse is comprised of thousands of historical flights and includes weather and track data collected from 2019. Using different subsets of relevant features (e.g., aircraft type), we trained several ML models to estimate the aircraft’s take off weight, drag polar coefficients (both parasitic and lift induced), and thrust settings (multiplier applied to the maximum engine thrust). The chosen flights are from three of the most common aircraft types (B738, B737, and A320) arriving at four airports (LAX, DEN, MSP, and DFW). Our ML approach is comprised of two different solutions: 1- using a subset of features that are known prior to the flight departure and do not change during flight (such as engine type, current temperature at departure & destination airports, aircraft type) and 2 - using a subset of temporal features of the flight trajectory (such as cruise altitude, Mach, airspeed, and rate of climb) in addition to the pre-departure features from the first solution. The labels or target variables are the APM parameters that were obtained by an optimized ordinary differential equations (ODE) fitting process (applied to individual flights). The ODE-fitting is very time intensive and is therefore performed offline. Thus, training an ML model to learn the relationship between the flight features and ODE-generated labels enables faster estimation of the APM parameters and is therefore amenable to real-time prediction. Various ML models including linear regression, random forest, XGBoost, and neural network were trained, and the results are compared. After model validation and hyperparameter-tuning, we observed that the Random Forest model outperformed the other three models by the overall mean square error (MSE) of 2% for the first solution and 1.5% for the second solution. Finally, the ML-derived parameters are compared against default BADA APM parameters using NASA’s Autonomy Development toolkit (ADK) simulation software. The simulation results for one of each aircraft type is shown and discussed.

Aida Sharif Rohani↗

Measuring Economy-Wide Circularity of the United States: An Input-Output Model in Mass Units

The ideal of creating closed material cycles by transforming the way we make, use and repurpose goods has become known as the circular economy. Besides its visionary appeal, material efficiency strategies central to circular economy can allow us to meet decarbonization goals that are otherwise out of reach. Production of basic materials such as cement, iron and steel and petrochemicals is one of the largest drivers of greenhouse gas emissions. Measuring circularity, and understanding its relationship with other sustainability metrics, however, is still difficult due to lack of data in mass units covering the entire economic system. Input-output (I-O) tables were originally created as a means of tracking the monetary flows that represent exchanges of goods and services within an economy, but have found additional uses in life cycle assessment and material flow accounts. In the traditional approach of environmentally extended I-O tables, emissions and energy data augment monetary flows. This approach can lead to price effects that distort physical quantities. Also, circular economy strategies and their goals relate to mass, not monetary flows. Therefore, it is best to simulate them using physical quantities. With these issues in mind, we have developed I-O tables in mass units to measure the flow of goods in the U.S. economy. This allows us to better measure how circular the economy really is, and how policy changes to affect this circularity may also affect decarbonization goals. Improving knowledge of these linkages could allow manufacturers to make changes in their production to achieve their sustainability and decarbonization targets. Our tool also provides a standard approach and public repository for data in physical units, making such data more available, useful, and meaningful. Following an established set of material flow metrics used by the European Union, we have used our tool to calculate material footprints over time differentiated by oil and gas versus other extractive industries. This approach also shows the relative trade balances of the U.S. in materials. We have developed a case study for the iron and steel sector, showing how different decarbonization scenarios affect not only economy-wide greenhouse gas emissions, but also total material use.

circular economy↗

A warm super-Neptune around the G-dwarf star TOI-1710 revealed with TESS, SOPHIE, and HARPS-N

We report the discovery and characterization of the transiting extrasolar planet TOI-1710 b. It was first identified as a promising candidate by the Transiting Exoplanet Survey Satellite. Its planetary nature was then established with SOPHIE and HARPS-N spectroscopic observations via the radial-velocity method. The stellar parameters for the host star are derived from the spectra and a joint Markov chain Monte-Carlo adjustment of the spectral energy distribution and evolutionary tracks of TOI-1710. A joint MCMC analysis of the TESS light curve and the radial-velocity evolution allows us to determine the planetary system properties. From our analysis, TOI 1710 b is found to be a massive warm super-Neptune (M p = 28.3 ± 4.7 M ⊕ and R p = 5.34 ± 0.11 R ⊕ ) orbiting a G5V dwarf star (T eff = 5665 ± 55 K) on a nearly circular 24.3-day orbit (e = 0.16 ± 0.08). The orbital period of this planet is close to the estimated rotation period of its host star P rot = 22.5 ± 2.0 days and it has a low Keplerian semi-amplitude K = 6.4 ± 1.0 m s -1 ; we thus performed additional analyses to show the robustness of the retrieved planetary parameters. With a low bulk density of 1.03 ± 0.23 g cm -3 and orbiting a bright host star (J = 8.3, V = 9.6), TOI-1710 b is one of the best targets in this mass-radius range (near the Neptunian desert) for atmospheric characterization via transmission spectroscopy, a key measurement in constraining planet formation and evolutionary models of sub-Jovian planets.

79 ASTRONOMY AND ASTROPHYSICS↗

DATASET RELEASE AND QUALITY CONTROL REVIEW OF LIVERMORE NEVADA NETWORK (LNN) RECORDINGS OF A SUBSET OF NEVADA NUCLEAR SECURITY SITE NUCLEAR EXPLOSIONS FROM 1979 TO 1992.

Geophysical research on historical nuclear tests is an important aspect of future monitoring capabilities in seismic research. This research is challenging due to the limited number of digital seismic recordings during the peak of nuclear testing (1945-1992). These limited records are unique and non-reproducible data with potential high research impact. Releasing available nuclear explosion seismic records to the explosion monitoring community is thus of high value and is the motivation for this dataset release. The target of this effort was on compilation and quality control of regional seismic records of nuclear explosions recorded on Lawrence Livermore National Laboratory stations ELK, KNB, LAC, and MNV, known collectively as the Livermore National Network (LNN) (Figure 1). LNN was established in the early 1960s for the primary purpose of monitoring underground nuclear testing at the former Nevada Test Site (NTS), now known as the Nevada Nuclear Security Site (NNSS) following the signing of the Limited Test Ban Treaty (LTBT). LNN consisted initially of short-period vertical component Benioff’s recorded on film located at Mina, NV (MNV) and Kanab, Utah (KNB). LNN added two additional stations at Landers, CA (LAC) and Elko, NV (ELK) in 1967 and upgraded equipment to broadband seismometers recorded on frequency modulation (FM) tapes from 1967-1979, followed by digital recordings after 1979 (Jarpe, 1989). The digital recordings were on a variety of now obsolete media, including 9-track, Exabyte, and DAT tapes. Jarpe (1989) describes the seismic station instrumentation details over the period of deployment. LNN recorded valuable non-repeatable unique data of several hundreds of nuclear explosions at NNSS, as well as earthquakes and chemical and mining explosions (Walter, 2020). The details of these nuclear tests are provided in the Department of Energy Report NV-209 Rev 16 (DOE, 2015).

58 GEOSCIENCES↗

Optical Sensors for Monitoring Gamma and Neutron Radiation

For safety and efficiency, nuclear reactors must be carefully monitored to provide feedback that enables the fission rate to be held at a constant target level via adjustments in the position of neutron-absorbing rods and moderating coolant flow rates. For automated reactor control, the monitoring system should provide calibrated analog or digital output. The sensors must survive and produce reliable output with minimal drift for at least one to two years, for replacement only during refueling. Small sensor size is preferred to enable more sensors to be placed in the core for more detailed characterization of the local fission rate and fuel consumption, since local deviations from the norm tend to amplify themselves. Currently, reactors are monitored by local power range meters (LPRMs) based on the neutron flux or gamma thermometers based on the gamma flux. LPRMs tend to be bulky, while gamma thermometers are subject to unwanted drift. Both electronic reactor sensors are plagued by electrical noise induced by ionizing radiation near the reactor core. A fiber optic sensor system was developed that is capable of tracking thermal neutron fluence and gamma flux in order to monitor nuclear reactor fission rates. The system provides near-real-time feedback from small- profile probes that are not sensitive to electromagnetic noise. The key novel feature is the practical design of fiber optic radiation sensors. The use of an actinoid element to monitor neutron flux in fiber optic EFPI (extrinsic Fabry-Perot interferometric) sensors is a new use of material. The materials and structure used in the sensor construction can be adjusted to result in a sensor that is sensitive to just thermal, gamma, or neutron stimulus, or any combination of the three. The tested design showed low sensitivity to thermal and gamma stimuli and high sensitivity to neutrons, with a fast response time.

Boyd, Clark D.↗

Autonomous Navigation for Deep Space Missions

Navigation (determining where the spacecraft is at any given time, controlling its path to achieve desired targets), performed using ground-in- the-loop techniques: (1) Data includes 2-way radiometric (Doppler, range), interferometric (Delta- Differential One-way Range), and optical (images of natural bodies taken by onboard camera) (2) Data received on the ground, processed to determine orbit, commands sent to execute maneuvers to control orbit. A self-contained, onboard, autonomous navigation system can: (1) Eliminate delays due to round-trip light time (2) Eliminate the human factors in ground-based processing (3) Reduce turnaround time from navigation update to minutes, down to seconds (4) React to late-breaking data. At JPL, we have developed the framework and computational elements of an autonomous navigation system, called AutoNav. It was originally developed as one of the technologies for the Deep Space 1 mission, launched in 1998; subsequently used on three other spacecraft, for four different missions. The primary use has been on comet missions to track comets during flybys, and impact one comet.

navigation↗

Design, construction, and validation of an in-situ groundwater trace element analyzer with applications in carbon storage

Abstract It is estimated that carbon emissions should reach net-zero by 2050 to meet important climate targets. Carbon capture is likely necessary to reach these targets, requiring a long-term storage solution such as geological carbon sequestration. However, as with any subsurface activity, leakage can occur, potentially impacting groundwater quality near the storage site. Rapid detection is essential to mitigate damage to this resource. Since CO 2 will acidify groundwater, the concentrations of acid soluble minerals and associated cations will increase. Thus, an in-situ, real-time element analysis system based on laser-induced breakdown spectroscopy (LIBS) is under development to monitor these elements. The system splits the traditional LIBS system into a miniature, all-optical sensor head built around a passively Q-switch laser fiber coupled to a control unit. Previous work has validated the LIBS technique for use at high pressure as well as the split system design. In this work, a fieldable prototype sensor is developed and tested in an onsite monitoring well where trace elements concentrations (approx. 0–3 ppm) were tracked over 20 days. These concentrations varied in response to local rainfall, diluting with increased rain, demonstrating the ability of a LIBS-based sensor to track trace elements under real-world conditions.

54 ENVIRONMENTAL SCIENCES↗

A Synthetic Pathway for Producing Carbon Dots for Detecting Iron Ions Using a Fiber Optic Spectrometer

Iron detection is of growing importance in the critical minerals sector, where unwanted iron ions are typically removed during the processing of target critical metals. The ideal sensor should utilize inexpensive, scalable materials along with a low-cost, robust, and easy-to-use analysis platform. Here, we demonstrate a simple acid–base synthesis of luminescent iron-responsive carbon dots by reacting ethanolamine, phosphoric acid, and m-phenylenediamine. The carbon dots exhibit selective, iron-specific emission quenching, with the ability to detect part-per-billion levels of iron ions even in 0.1 M HCl. After benchmarking the purified materials using a commercial spectrometer, a “low-cost” process is demonstrated in which carbon dots with minimal purification are coupled with a portable fiber-optic spectrometer for analyzing iron content. Carbon dot-coated paper strips are also evaluated as another convenient platform for iron analysis. Taken together, the sensing material and platforms demonstrated here are well-suited for detecting trace quantities of iron in environmentally relevant conditions, with potential applications in tracking iron removal processes during critical mineral production as one exciting area of interest.

acid mine draining↗

NASA’s Progress Toward Commercial Space Communications—SATCOM Demonstrations and Wideband Multilingual Terminal Development

The National Aeronautics and Space Administration (NASA) Space Communications and Navigation (SCaN) Program is continuing to forge a path toward programmatic and operational transformation enabling commercialization of communications and navigation services to the greatest extent possible for near Earth users. National Space Policy is driving government agencies to incorporate commercial offerings and services to the maximum extent possible. As such, NASA has no plans to build or deploy Tracking and Data Relay Satellites, but will seek to fill NASA mission space-relay capability needs using commercial satellite communications (SATCOM) providers and services. The goal is to support an approach that is both flexible to commercial service constructs and provides continuity of support with current assets as long as required. Progress toward commercialization is advancing in two key areas: (1) awards have been made for demonstrations of SATCOM services, and (2) development of wideband and multilingual user terminals has advanced to the flight demonstration phase. The Communications Services Project (CSP) at Glenn Research Center (GRC), has awarded Funded Space Act Agreements (FSAA) to six industry vendors. Inmarsat Government Inc., Kuiper Government Solutions (KGS) LLC, SES Government Solutions, Space Exploration Technologies, Telesat U.S. Services LLC, and Viasat Incorporated received a combined $278.5 million to complete technology development and in-space demonstrations over the next several years. The end-to-end service capabilities being targeted are based on existing NASA mission operational needs. Accordingly, each company has proposed a technical approach to lower costs, increase flexibility, and improve performance for a broad range of missions. In the current market, industry vendors operate at a range of different frequencies and use variable, sometime proprietary, coding and modulations schemes. As NASA strives for a network comprised of services provided by multiple distinct suppliers, interoperability is a fitting solution to unify the network. Wideband and multi-lingual user terminals are being developed to bridge differences in industry services. Building on ground demonstrations completed in 2021, the Johns Hopkins Applied Physics Lab (APL) will be flight testing a multi-lingual wideband terminal (payload) and demonstrating connectivity to both government and commercial relay services. This paper provides a discussion of the progress toward NASA’s commercial space communications goals and consideration of key challenges and next steps.

space communications↗

First Assessments of Predicted ICESat-2 Performance Using Aircraft Data

The Ice, Cloud, and land Elevation Satellite-2 (ICESat-2) is a next-generation laser altimeter designed to continue key observations of ice sheet elevation change, sea ice freeboard, vegetation canopy height, earth surface elevation, and sea surface height. Scheduled for launch in mid-2016, ICESat-2 will use a high repetition rate (10 kHz), small footprint (10 m nominal ground diameter) laser, and a single-photon-sensitive detection strategy (photon counting) to measure precise range to the earth's surface. Using green light (532 nm), the six beams of ICESat-2 will provide improved spatial coverage compared with the single beam of ICESat, while the differences in transmit energy among the beams provide a large dynamic range. The six beams are arranged into three pairs of beams which allow slopes to measured on an orbit-by-orbit basis. In order to evaluate models of predicted ICESat-2 performance and provide ICESat-2-like data for algorithm development, an airborne ICESat-2 simulator was developed and first flown in 2010. This simulator, the Multiple Altimeter Beam Experimental Lidar (MABEL) was most recently deployed to Iceland in April 2012 and collected approx 85 hours of science data over land ice, sea ice, and calibration targets. MABEL uses a similar photon-counting measurement strategy to what will be used on ICESat-2. MABEL collects data in 16 green channels and an additional 8 channels in the infrared aligned across the direction of flight. By using NASA's ER-2 aircraft flying at 20km altitude, MABEL flies as close to space as is practical, and collects data through approx 95% of the atmosphere. We present background on the MABEL instrument, and data from the April 2012 deployment to Iceland. Among the 13 MABEL flights, we collected data over the Greenland ice sheet interior and outlet glaciers in the southwest and western Greenland, sea ice data over the Nares Strait and Greenland Sea, and a number of small glaciers and ice caps in Iceland and Svalbard. Several of the flights were coincident in time and space with NASA's Operation IceBridge, which provides an independent data set for validation. MABEL also collected data along CryoSat track 10482 in north central Greenland approximately one month after CryoSat passed overhead.

Neumann, Thomas↗

NASA's Progress Toward Commercial Space Communications — SATCOM Demonstrations and Wideband Multilingual Terminal Development

The National Aeronautics and Space Administration (NASA) Space Communications and Navigation (SCaN) Program is continuing to forge a path toward programmatic and operational transformation enabling commercialization of communications and navigation services to the greatest extent possible for near Earth users. U.S. National Space Policy is driving government agencies to incorporate commercial offerings and services to the maximum extent possible. As such, NASA has no plans to build or deploy additional Tracking and Data Relay Satellites (TDRS), but will seek to fill NASA mission space-relay capability needs using commercial satellite communications (SATCOM) providers and services. The goal is to support an approach that is both flexible to commercial service constructs and provides continuity of support with current assets as long as required. Progress toward commercial services is advancing in two key areas: (1) awards have been made for demonstrations of SATCOM services, and (2) development of wideband and multilingual user terminals has advanced to the flight demonstration phase. The Communications Services Project (CSP) at Glenn Research Center (GRC), has awarded Funded Space Act Agreements (FSAA) to six industry vendors. Inmarsat Government Inc., Kuiper Government Solutions (KGS) LLC, SES Government Solutions, Space Exploration Technologies, Telesat U.S. Services LLC, and Viasat Incorporated will receive a combined $278.5 million to complete technology development and in-space demonstrations over the next several years. The end-to-end service capabilities being targeted are based on existing NASA mission operational needs. Accordingly, each company has proposed a technical approach to lower costs, increase flexibility, and improve performance for a broad range of missions. In the current market, industry vendors operate at a range of different frequencies and use variable, sometimes proprietary, coding and modulations schemes. As NASA strives for a network comprised of services provided by multiple distinct suppliers, interoperability is a fitting solution to unify the network. Wideband and multi-lingual user terminals are being developed to bridge differences in industry services. Building on ground demonstrations completed in 2021, the Johns Hopkins Applied Physics Lab (APL) will be flight testing a multi-lingual wideband terminal (payload) and demonstrating connectivity to both government and commercial relay services. This paper provides a discussion of the progress toward NASA’s commercial space communications goals and consideration of key challenges and next steps.

commercialization↗

A Telomerase-Activated Magnetic Resonance Imaging Probe for Consecutively Monitoring Tumor Growth Kinetics and In Situ Screening Inhibitors

Telomerase has long been considered as a biomarker for cancer diagnosis and a therapeutic target for drug discovery. Detecting telomerase activity in vivo could provide more direct information of tumor progression and response to drug treatment, which, however, is hampered by the lack of an effective probe that can generate an output signal without a tissue penetration depth limit. Here in this study, using the principle of distance-dependent magnetic resonance tuning, we constructed a telomerase-activated magnetic resonance imaging probe (TAMP) by connecting superparamagnetic ferroferric oxide nanoparticles (SPFONs) and paramagnetic Gd-DOTA (Gd(III) 1,4,7,10- tetraazacyclododecane-1,4,7,10-tetraazacyclododecane-1,4,7,10-tet-raacetic acid) complexes via telomerase-responsive DNA motifs. Upon telomerase-catalyzed extension of the primer in TAMP, Gd-DOTA-conjugated oligonucleotides can be liberated from the surface of SPFONs through a DNA strand displacement reaction, restoring the T 1 signal of the Gd-DOTA for a direct readout of the telomerase activity. Here we show that, by tracking telomerase activity, this probe provides consistent monitoring of tumor growth kinetics during progression and in response to drug treatment and enables in situ screening of telomerase inhibitors in whole-animal models. This study provides an alternative toolkit for cancer diagnosis, treatment response assessment, and anticancer drug screening.

37 INORGANIC, ORGANIC, PHYSICAL, AND ANALYTICAL CH↗

JGI Plant Gene Atlas: an updateable transcriptome resource to improve functional gene descriptions across the plant kingdom

Abstract Gene functional descriptions offer a crucial line of evidence for candidate genes underlying trait variation. Conversely, plant responses to environmental cues represent important resources to decipher gene function and subsequently provide molecular targets for plant improvement through gene editing. However, biological roles of large proportions of genes across the plant phylogeny are poorly annotated. Here we describe the Joint Genome Institute (JGI) Plant Gene Atlas, an updateable data resource consisting of transcript abundance assays spanning 18 diverse species. To integrate across these diverse genotypes, we analyzed expression profiles, built gene clusters that exhibited tissue/condition specific expression, and tested for transcriptional response to environmental queues. We discovered extensive phylogenetically constrained and condition-specific expression profiles for genes without any previously documented functional annotation. Such conserved expression patterns and tightly co-expressed gene clusters let us assign expression derived additional biological information to 64 495 genes with otherwise unknown functions. The ever-expanding Gene Atlas resource is available at JGI Plant Gene Atlas (https://plantgeneatlas.jgi.doe.gov) and Phytozome (https://phytozome.jgi.doe.gov/), providing bulk access to data and user-specified queries of gene sets. Combined, these web interfaces let users access differentially expressed genes, track orthologs across the Gene Atlas plants, graphically represent co-expressed genes, and visualize gene ontology and pathway enrichments.

59 BASIC BIOLOGICAL SCIENCES↗

[Activities of System Studies and Simulation, Inc.]

Contents include the following: 1. Launch Vehicle Interface Work Performed: a. S3 provided to KSC the new launch inclination targets needed for the April '04 launch date. 2. Prelaunch operations work performed: a. S3 updated the staffing plan for MSFC on-console personnel\during the Final Countdown prior to launch. 3. Software Assessment Work Performed: a. S3 evaluated and recommended approval for Program Control Board (PCB) proposed change 649 for ground software changes, as well as change 650 and 650A for Stored Program Commands. 4. Education and Public Outreach Work Performed: a. S3 continues to coordinate the effort for the design and fabrication of scale models of the GP-3 for use at the launch site, education forums, and management/technical briefings. S3 also prepared a Change Request for additional funds needed for fabrication of additional scale models. S3 drafted the planned uses of these models, including the possibility of participation in the Boston, MA showings of the traveling Einstein Exhibit. 5. Program Management Support Work Performed: a. S3 prepared the input for and closed three MSFC Centerwide Action Item Tracking Systems (CAITS) actions during this period.

Source record↗

Neutrinos from the Galactic Center Hosting a Hypernova Remnant

Similar to star-forming galaxies or starburst galaxies, star-forming regions in our Galaxy can host cosmic-ray (CR) accelerators and rich gas as targets of hadronuclear interaction. By our estimations, the IceCube neutrino observatory might detect muon neutrinos from a CR accelerator associated with a molecular cloud complex in our Galaxy. The associated high-energy gamma-ray emission might be observed by the Cherenkov Telescope Array (CTA), High-Altitude Water Cherenkov Gamma-Ray Observatory (HAWC), and Large High Altitude Air Shower Observatory (LHAASO). Furthermore, taking the Galactic Center (GC) region as an example, we assume that a hypernova exploded in the past in the GC. We simulate the acceleration of CRs in the hypernova remnant (HNR) as well as their confinement and escape. The high-energy protons escape from the HNR, diffuse around the GC, interact with molecular clouds, and then produce gamma-rays and neutrinos. In the optimal cases, the GC would be a promising 100 TeV gamma-ray source for LHAASO’s one-month observation. We propose that neutrino-induced searching for starting track-like and high-energy starting events (HESEs) observed by IceCube, from the GC region with a radius of 1°.8, would help us discover the particle accelerator in the GC or constrain our models. Under the constraint from high-energy gamma-ray observations by the H.E.S.S. telescope, we estimate the exposure time needed to make a significant discovery for the optimal cases. The analysis combining observations of IceCube and ANTARES, starting track-like events and HESEs, future observations by neutrino detectors IceCube-Gen2 and KM3net, and gamma-ray telescopes CTA, HAWC, and LHAASO would help to constrain our models.

79 ASTRONOMY AND ASTROPHYSICS↗