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At least 1,423 records · Page 79
All sourcesNASA NTRSDOE OSTI
DOE OSTI2015

Asymmetric projections of the arcuate fasciculus to the temporal cortex underlie lateralized language function in the human brain

The arcuate fasciculus (AF) in the human brain has asymmetric structural properties. However, the topographic organization of the asymmetric AF projections to the cortex and its relevance to cortical function remain unclear. Here we mapped the posterior projections of the human AF in the inferior parietal and lateral temporal cortices using surface-based structural connectivity analysis based on diffusion MRI and investigated their hemispheric differences. We then performed the cross-modal comparison with functional connectivity based on resting-state functional MRI (fMRI) and task-related cortical activation based on fMRI using a semantic classification task of single words. Structural connectivity analysis showed that the left AF connecting to Broca's area predominantly projected in the lateral temporal cortex extending from the posterior superior temporal gyrus to the mid part of the superior temporal sulcus and the middle temporal gyrus, whereas the right AF connecting to the right homolog of Broca's area predominantly projected to the inferior parietal cortex extending from the mid part of the supramarginal gyrus to the anterior part of the angular gyrus. The left-lateralized projection regions of the AF in the left temporal cortex had asymmetric functional connectivity with Broca's area, indicating structure-function concordance through the AF. During the language task, left-lateralized cortical activation was observed. Among them, the brain responses in the temporal cortex and Broca's area that were connected through the left-lateralized AF pathway were specifically correlated across subjects. These results suggest that the human left AF, which structurally and functionally connects the mid temporal cortex and Broca's area in asymmetrical fashion, coordinates the cortical activity in these remote cortices during a semantic decision task. As a result, the unique feature of the left AF is discussed in the context of the human capacity for language.

59 BASIC BIOLOGICAL SCIENCES↗
DOE OSTI2022

Brown Dog Tick (Rhipicephalus sanguineus Sensu Lato) Infection with Endosymbiont and Human Pathogenic Rickettsia spp., in Northeastern México

Of the documented tick-borne diseases infecting humans in México, Rocky Mountain spotted fever (RMSF), caused by the Gram-negative bacterium Rickettsia rickettsii, is responsible for most fatalities. Given recent evidence of brown dog tick, Rhipicephalus sanguineus s.l., as an emerging vector of human RMSF, we aimed to evaluate dogs and their ticks for rickettsiae infections as an initial step in assessing the establishment of this pathosystem in a poorly studied region of northeastern México while evaluating the use of dogs as sentinels for transmission/human disease risk. We sampled owned dogs living in six disadvantaged neighborhoods of Reynosa, northeastern México to collect whole blood and ticks. Of 168 dogs assessed, tick infestation prevalence was 53%, composed of exclusively Rh. sanguineus s. l. (n = 2170 ticks). Using PCR and sequencing, we identified an overall rickettsiae infection prevalence of 4.1% (n = 12/292) in ticks, in which eight dogs harbored at least one infected tick. Rickettsiae infections included Rickettsia amblyommatis and Rickettsia parkeri, both of which are emerging human pathogens, as well as Candidatus Rickettsia andeanae. This is the first documentation of pathogenic Rickettsia species in Rh. sanguineus s.l. collected from dogs from northeastern México. Domestic dog infestation with Rickettsia-infected ticks indicates ongoing transmission; thus, humans are at risk for exposure, and this underscores the importance of public and veterinary health surveillance for these pathogens.

60 APPLIED LIFE SCIENCES↗
DOE OSTI2019

Impact of Climate Variabilities and Human Activities on Surface Water Extents in Reservoirs of Yongding River Basin, China, from 1985 to 2016 Based on Landsat Observations and Time Series Analysis

Yongding River is the largest river flowing through Beijing, the capital city of China. In recent years, Yongding River Basin (YDRB) has seen increasing human impacts on water resources, posing serious challenges in hydrological and ecological health. In this study, remote sensing techniques and statistical time series approaches for hydrological studies were combined to characterize the dynamics and driving factors of reservoir water extents in YDRB during 1985–2016. First, 107 Landsat 4, 5, 7 and 8 images were used to extract surface water extents in YDRB during 1985–2016 using a combination of water indices and Otsu threshold algorithm. Significant positive correlation was found between water extents and the annual inflow for the two biggest reservoirs, the downstream Guanting and upstream Cetian reservoirs, proving their representativeness of surface water availability in this basin. Then, statistical time series approaches including trend-free pre-whitening Mann-Kendall trend test, Pettit change-point test and double mass curve method, which are frequently used in hydrological studies, were adopted to quantify the trend of reservoir water extents dynamics and the relative contributions of climate variability and human activities. Results showed that the water extents in both reservoirs exhibited significant downward trend with change point occurring in 2001 and 2005 for Guanting and Cetian, respectively. About 74%~75% of the shrinkage during the post-change period can be attributed to human activities, among which GDP, population, electricity power production, raw coal production, steel and crude iron production, value of agriculture output, and urban area were the major human drivers. Hydrological connectivity between the upstream Cetian and downstream Guanting reservoirs declined during the post-change period. Since 2012, water extents in both reservoirs recovered as a result of various governmental water management policies including the South-to-North Water Diversion Project. The methodology introduced in this study can be used for analyzing the dynamics and driving mechanism of surface water resources, especially for un-gauged or poorly-gauged watersheds.

47 OTHER INSTRUMENTATION↗
DOE OSTI2014

Enhanced homology-directed human genome engineering by controlled timing of CRISPR/Cas9 delivery

The CRISPR/Cas9 system is a robust genome editing technology that works in human cells, animals and plants based on the RNA-programmed DNA cleaving activity of the Cas9 enzyme. Building on previous work ( Jinek et al., 2013 ), we show here that new genetic information can be introduced site-specifically and with high efficiency by homology-directed repair (HDR) of Cas9-induced site-specific double-strand DNA breaks using timed delivery of Cas9-guide RNA ribonucleoprotein (RNP) complexes. Cas9 RNP-mediated HDR in HEK293T, human primary neonatal fibroblast and human embryonic stem cells was increased dramatically relative to experiments in unsynchronized cells, with rates of HDR up to 38% observed in HEK293T cells. Sequencing of on- and potential off-target sites showed that editing occurred with high fidelity, while cell mortality was minimized. This approach provides a simple and highly effective strategy for enhancing site-specific genome engineering in both transformed and primary human cells.

Life Sciences & Biomedicine - Other Topics↗
DOE OSTI2024

Analysis of twelve genomes of the bacterium Kerstersia gyiorum from brown-throated sloths ( Bradypus variegatus ), the first from a non-human host

Kerstersia gyiorum is a Gram-negative bacterium found in various animals, including humans, where it has been associated with various infections. Knowledge of the basic biology of K. gyiorum is essential to understand the evolutionary strategies of niche adaptation and how this organism contributes to infectious diseases; however, genomic data about K. gyiorum is very limited, especially from non-human hosts. In this work, we sequenced 12 K. gyiorum genomes isolated from healthy free-living brown-throated sloths (Bradypus variegatus) in the Parque Estadual das Fontes do Ipiranga (São Paulo, Brazil), and compared them with genomes from isolates of human origin, in order to gain insights into genomic diversity, phylogeny, and host specialization of this species. Phylogenetic analysis revealed that these K. gyiorum strains are structured according to host. Despite the fact that sloth isolates were sampled from a single geographic location, the intra-sloth K. gyiorum diversity was divided into three clusters, with differences of more than 1,000 single nucleotide polymorphisms between them, suggesting the circulation of various K. gyiorum lineages in sloths. Genes involved in mobilome and defense mechanisms against mobile genetic elements were the main source of gene content variation between isolates from different hosts. Sloth-specific K. gyiorum genome features include an IncN2 plasmid, a phage sequence, and a CRISPR-Cas system. The broad diversity of defense elements in K. gyiorum (14 systems) may prevent further mobile element flow and explain the low amount of mobile genetic elements in K. gyiorum genomes. Gene content variation may be important for the adaptation of K. gyiorum to different host niches. This study furthers our understanding of diversity, host adaptation, and evolution of K. gyiorum, by presenting and analyzing the first genomes of non-human isolates.

59 BASIC BIOLOGICAL SCIENCES↗
NASA NTRS1973

Combining human and computer interpretation capabilities to analyze ERTS imagery

The human photointerpreter and the computer have complementary capabilities that are exploited in a computer-based data analysis system developed at the Forestry Remote Sensing Laboratory, University of California. This system is designed to optimize the process of extracting resource information from ERTS images. The human has the ability to quickly delineate gross differences in land classes, such as wildland, urban, and agriculture on appropriate ERTS images, and to further break these gross classes into meaningful subclasses. The computer, however, can more efficiently analyze point-by-point spectral information and localized textural information which can result in a much more detailed agricultural or wildland classification based on species composition and/or plant association. These human and computer capabilities have been integrated through the use of an inexpensive small scale computer dedicated to the interactive preprocessing of the human inputs and the display of raw ERTS images and computer classified images. The small computer is linked to a large scale computer system wherein the bulk of the statistical work and the automatic point-by-point classification is done.

Nichols, J. D.↗
NASA NTRS1972

Simulation of a steady-state integrated human thermal system.

The mathematical model of an integrated human thermal system is formulated. The system consists of an external thermal regulation device on the human body. The purpose of the device (a network of cooling tubes held in contact with the surface of the skin) is to maintain the human body in a state of thermoneutrality. The device is controlled by varying the inlet coolant temperature and coolant mass flow rate. The differential equations of the model are approximated by a set of algebraic equations which result from the application of the explicit forward finite difference method to the differential equations. The integrated human thermal system is simulated for a variety of combinations of the inlet coolant temperature, coolant mass flow rate, and metabolic rates.

Hsu, F. T.↗
NASA NTRS1973

Human eye movements during various forms of linear acceleration and weightlessness

Eye movements of human subjects were recorded electronystagmographically in complete darkness during rectilinear horizontal accelerations as achieved in cars on the ground and also during aircraft parabolic flight. The results were compared to the movements of blinded goldfish subjected to similar changes of gravitoinertial forces. The results indicate that there is a human correlation with the gravity reference response of fish. During horizontal forward accelerations on the ground the human eyes turn downward and during horizontal backward acceleration the eyes turn upward. The human eye response to g-loads below 1 g and to weightlessness is the reverse of the tilt of the fish. While fish dive down during low g, or loop forward during weightlessness, the eyes of subjects sitting upright in an aircraft which flies at 0 g move upward.

Vonbaumgarten, R. J.↗
NASA NTRS1975

A Method for the Study of Human Factors in Aircraft Operations

A method for the study of human factors in the aviation environment is described. A conceptual framework is provided within which pilot and other human errors in aircraft operations may be studied with the intent of finding out how, and why, they occurred. An information processing model of human behavior serves as the basis for the acquisition and interpretation of information relating to occurrences which involve human error. A systematic method of collecting such data is presented and discussed. The classification of the data is outlined.

Barnhart, W.↗
NASA NTRS1978

On humanity's role in space

Manned spaceflight is considered within the framework of two broad categories: human exploitation of space for economic or scientific gain, and human habitation of space as a place where man may live, grow, and actualize himself. With the advent of the Space Shuttle, exploitation of space will take the form of new product development. This will continue during the 1990s as the new products are manufactured on a scale large enough to be profitable. The turn of the century should see major industries in space, and large space habitats. Thus, the question of mankind's existential needs arises. In addition to basic physical needs, the spiritual and cultural requirements of human beings must be considered. The impact of man's presence in space upon human culture in general is discussed with reference to international cooperation, public interest in space programs, scientific advancement, the basic urge to explore, and the density of mankind as a whole; which will become free of external constraints as we step into the cosmos.

Von Puttkamer, J.↗
NASA NTRS1978

Human problem solving performance in a fault diagnosis task

It is proposed that humans in automated systems will be asked to assume the role of troubleshooter or problem solver and that the problems which they will be asked to solve in such systems will not be amenable to rote solution. The design of visual displays for problem solving in such situations is considered, and the results of two experimental investigations of human problem solving performance in the diagnosis of faults in graphically displayed network problems are discussed. The effects of problem size, forced-pacing, computer aiding, and training are considered. Results indicate that human performance deviates from optimality as problem size increases. Forced-pacing appears to cause the human to adopt fairly brute force strategies, as compared to those adopted in self-paced situations. Computer aiding substantially lessens the number of mistaken diagnoses by performing the bookkeeping portions of the task.

Rouse, W. B.↗
NASA NTRS1978

A method motion simulator design based on modeling characteristics of the human operator

A design criteria is obtained to compare two simulators and evaluate their equivalence or credibility. In the subsequent analysis the comparison of two simulators can be considered as the same problem as the comparison of a real world situation and a simulation's representation of this real world situation. The design criteria developed involves modeling of the human operator and defining simple parameters to describe his behavior in the simulator and in the real world situation. In the process of obtaining human operator parameters to define characteristics to evaluate simulators, measures are also obtained on these human operator characteristics which can be used to describe the human as an information processor and controller. First, a study is conducted on the simulator design problem in such a manner that this modeling approach can be used to develop a criteria for the comparison of two simulators.

Repperger, D. W.↗
NASA NTRS1978

Combined monitoring, decision and control model for the human operator in a command and control desk

A report is given on the ongoing efforts to mode the human operator in the context of the task during the enroute/return phases in the ground based control of multiple flights of remotely piloted vehicles (RPV). The approach employed here uses models that have their analytical bases in control theory and in statistical estimation and decision theory. In particular, it draws heavily on the modes and the concepts of the optimal control model (OCM) of the human operator. The OCM is being extended into a combined monitoring, decision, and control model (DEMON) of the human operator by infusing decision theoretic notions that make it suitable for application to problems in which human control actions are infrequent and in which monitoring and decision-making are the operator's main activities. Some results obtained with a specialized version of DEMON for the RPV control problem are included.

Muralidharan, R.↗
NASA NTRS1980

Some problems of human adaptation and ecology under the aspect of general pathology

The main problems of human adaptation at the level of the body and the population in connection with the features of current morbidity of the population and certain demographic processes are analyzed. The concepts of health and adaptation of the individual and human populations are determined. The importance of the anthropo-ecological approach to the investigation of the adaptation process of human populations is demonstrated. Certain features of the etiopathogenesis of diseases are considered in connection with the population-ecological regularities of human adaptation. The importance of research on general pathology aspects of adaptation and the ecology of man for planning, and organization of public health protection is discussed.

Kaznacheyev, V. P.↗
NASA NTRS1979

Adaptive allocation of decisionmaking responsibility between human and computer in multitask situations

As human and computer come to have overlapping decisionmaking abilities, a dynamic or adaptive allocation of responsibilities may be the best mode of human-computer interaction. It is suggested that the computer serve as a backup decisionmaker, accepting responsibility when human workload becomes excessive and relinquishing responsibility when workload becomes acceptable. A queueing theory formulation of multitask decisionmaking is used and a threshold policy for turning the computer on/off is proposed. This policy minimizes event-waiting cost subject to human workload constraints. An experiment was conducted with a balanced design of several subject runs within a computer-aided multitask flight management situation with different task demand levels. It was found that computer aiding enhanced subsystem performance as well as subjective ratings. The queueing model appears to be an adequate representation of the multitask decisionmaking situation, and to be capable of predicting system performance in terms of average waiting time and server occupancy. Server occupancy was further found to correlate highly with the subjective effort ratings.

Chu, Y.-Y.↗
NASA NTRS1980

A theory of human error

Human error, a significant contributing factor in a very high proportion of civil transport, general aviation, and rotorcraft accidents is investigated. Correction of the sources of human error requires that one attempt to reconstruct underlying and contributing causes of error from the circumstantial causes cited in official investigative reports. A validated analytical theory of the input-output behavior of human operators involving manual control, communication, supervisory, and monitoring tasks which are relevant to aviation operations is presented. This theory of behavior, both appropriate and inappropriate, provides an insightful basis for investigating, classifying, and quantifying the needed cause-effect relationships governing propagation of human error.

Mcruer, D. T.↗
NASA NTRS1981

Plant diversity to support humans in a CELSS ground based demonstrator

A controlled ecological life support system (CELSS) for human habitation in preparation for future long duration space flights is considered. The success of such a system depends upon the feasibility of revitalization of food resources and the human nutritional needs which are to be met by these food resources. Edible higher plants are prime candidates for the photoautotrophic components of this system if nutritionally adequate diets can be derived from these plant sources to support humans. Human nutritional requirements information based on current knowledge are developed for inhabitants envisioned in the CELSS ground based demonstrator. Groups of plant products that can provide the nutrients are identified.

Howe, J. M.↗
NASA NTRS1982

Modeling of human operator dynamics in simple manual control utilizing time series analysis

Time series analysis is applied to model human operator dynamics in pursuit and compensatory tracking modes. The normalized residual criterion is used as a one-step analytical tool to encompass the processes of identification, estimation, and diagnostic checking. A parameter constraining technique is introduced to develop more reliable models of human operator dynamics. The human operator is adequately modeled by a second order dynamic system both in pursuit and compensatory tracking modes. In comparing the data sampling rates, 100 msec between samples is adequate and is shown to provide better results than 200 msec sampling. The residual power spectrum and eigenvalue analysis show that the human operator is not a generator of periodic characteristics.

Agarwal, G. C.↗