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At least 1,423 records · Page 79

WE-G-BRD-03: Development of a Real-Time Optical Tracking Goggle System (OTGS) for Intracranial Stereotactic Radiotherapy

Purpose: Optical tracking systems (OTS) are an acceptable alternative to frame-based stereotactic radiotherapy (SRT). However, current surface-based OTS lack the ability to target exclusively rigid/bony anatomical features. We propose a novel marker-based optical tracking goggle system (OTGS) that provides real-time guidance based on the nose/facial bony anatomy. This ongoing study involves the development and characterization of the OTGS for clinical implementation in intracranial stereotactic radiotherapy. Methods: The OTGS consists of eye goggles, a custom thermoplastic nosepiece, and 6 infrared markers pre-attached to the goggles. A phantom and four healthy volunteers were used to evaluate the calibration/registration accuracy, intrafraction accuracy, interfraction reproducibility, and end-to-end accuracy of the OTGS. The performance of the OTGS was compared with that of the frameless SonArray system and cone-beam computed tomography (CBCT) for volunteer and phantom cases, respectively. The performance of the OTGS with commercial immobilization devices and under treatment conditions (i.e., couch rotation and translation range) was also evaluated. Results: The difference in the calibration/registration accuracy of 24 translations or rotation combinations between CBCT and in-house OTS software was within 0.5 mm/0.4°. The mean intrafraction and interfraction accuracy among the volunteers was 0.004+/−0.4mm with −0.09+/−0.5° (n=6,170) and −0.26+/−0.8mm with 0.15+/0.8° (n=11), respectively. The difference in end-to-end accuracy between the OTGS and CBCT was within 1.3 mm/1.1°. The predetermined marker pattern (1) minimized marker occlusions, (2) allowed for continuous tracking for couch angles +/− 90°, (3) and eliminated individual marker misplacement. The device was feasible with open and half masks for immobilization. Conclusion: Bony anatomical localization eliminated potential errors due to facial hair changes and/or soft tissue deformation. The OTGS offers a workflow-friendly, patient-friendly solution for intracranial SRT, while being comparable to other real-time options. The minimum rotation uncertainty of the OTGS can be combined with CBCT to ensure maximum accuracy for high-precision SRT.

60 APPLIED LIFE SCIENCES↗

TU-A-210-00: HIFU Therapies - A Primer

High-intensity focused ultrasound (HIFU) has developed rapidly in recent years and is used frequently for clinical treatments in Asia and Europe with increasing clinical use and clinical trial activity in the US, making it an important medical technology with which the medical physics community must become familiar. Akin to medical devices that deliver treatments using ionizing radiation, HIFU relies on emitter geometry to non-invasively form a tight focus that can be used to affect diseased tissue while leaving healthy tissue intact. HIFU is unique in that it does not involve the use of ionizing radiation, it causes thermal necrosis in 100% of the treated tissue volume, and it has an immediate treatment effect. However, because it is an application of ultrasound energy, HIFU interacts strongly with tissue interfaces, which makes treatment planning challenging. In order to appreciate the advantages and disadvantages of HIFU as a thermal therapy, it is important to understand the underlying physics of ultrasound tissue interactions. The first lecture in the session will provide an overview of the physics of ultrasound wave propagation; the mechanism for the accumulation of heat in soft-tissue; image-guidance modalities including temperature monitoring; current clinical applications and commercial devices; active clinical trials; alternate mechanisms of action (future of FUS). The second part of the session will compare HIFU to existing ionization radiation techniques. The difficulties in defining a clear concept of absorbed dose for HIFU will be discussed. Some of the technical challenges that HIFU faces will be described, with an emphasis on how the experience of radiation oncology physicists could benefit the field. Learning Objectives: Describe the basic physics and biology of HIFU, including treatment delivery and image guidance techniques. Summarize existing and emerging clinical applications and manufacturers for HIFU. Understand that thermal ablation with HIFU is likely the first of several applications of the technology Learn about some similarities and differences between HIFU and ionizing radiation in terms of physics and biological effects. Learn about some of the technical challenges HIFU faces that might benefit from the experience of radiation oncology physicists including treatment planning improvements, quality assurance procedures, and treatment risk analysis. David Schlesinger receives research support from Elekta Instruments, AB. Matt Eames is an employee of the Focused Ultrasound Foundation which supports research and clinical trials. Dr. Eames conducts research which is supported by the Focused Ultrasound Foundation.

60 APPLIED LIFE SCIENCES↗

TU-A-210-01: HIFU Physics and Delivery

High-intensity focused ultrasound (HIFU) has developed rapidly in recent years and is used frequently for clinical treatments in Asia and Europe with increasing clinical use and clinical trial activity in the US, making it an important medical technology with which the medical physics community must become familiar. Akin to medical devices that deliver treatments using ionizing radiation, HIFU relies on emitter geometry to non-invasively form a tight focus that can be used to affect diseased tissue while leaving healthy tissue intact. HIFU is unique in that it does not involve the use of ionizing radiation, it causes thermal necrosis in 100% of the treated tissue volume, and it has an immediate treatment effect. However, because it is an application of ultrasound energy, HIFU interacts strongly with tissue interfaces, which makes treatment planning challenging. In order to appreciate the advantages and disadvantages of HIFU as a thermal therapy, it is important to understand the underlying physics of ultrasound tissue interactions. The first lecture in the session will provide an overview of the physics of ultrasound wave propagation; the mechanism for the accumulation of heat in soft-tissue; image-guidance modalities including temperature monitoring; current clinical applications and commercial devices; active clinical trials; alternate mechanisms of action (future of FUS). The second part of the session will compare HIFU to existing ionization radiation techniques. The difficulties in defining a clear concept of absorbed dose for HIFU will be discussed. Some of the technical challenges that HIFU faces will be described, with an emphasis on how the experience of radiation oncology physicists could benefit the field. Learning Objectives: Describe the basic physics and biology of HIFU, including treatment delivery and image guidance techniques. Summarize existing and emerging clinical applications and manufacturers for HIFU. Understand that thermal ablation with HIFU is likely the first of several applications of the technology Learn about some similarities and differences between HIFU and ionizing radiation in terms of physics and biological effects. Learn about some of the technical challenges HIFU faces that might benefit from the experience of radiation oncology physicists including treatment planning improvements, quality assurance procedures, and treatment risk analysis. David Schlesinger receives research support from Elekta Instruments, AB. Matt Eames is an employee of the Focused Ultrasound Foundation which supports research and clinical trials. Dr. Eames conducts research which is supported by the Focused Ultrasound Foundation.

60 APPLIED LIFE SCIENCES↗

TU-A-210-02: HIFU: Why Should a Radiation Oncology Physicist Pay Attention?

High-intensity focused ultrasound (HIFU) has developed rapidly in recent years and is used frequently for clinical treatments in Asia and Europe with increasing clinical use and clinical trial activity in the US, making it an important medical technology with which the medical physics community must become familiar. Akin to medical devices that deliver treatments using ionizing radiation, HIFU relies on emitter geometry to non-invasively form a tight focus that can be used to affect diseased tissue while leaving healthy tissue intact. HIFU is unique in that it does not involve the use of ionizing radiation, it causes thermal necrosis in 100% of the treated tissue volume, and it has an immediate treatment effect. However, because it is an application of ultrasound energy, HIFU interacts strongly with tissue interfaces, which makes treatment planning challenging. In order to appreciate the advantages and disadvantages of HIFU as a thermal therapy, it is important to understand the underlying physics of ultrasound tissue interactions. The first lecture in the session will provide an overview of the physics of ultrasound wave propagation; the mechanism for the accumulation of heat in soft-tissue; image-guidance modalities including temperature monitoring; current clinical applications and commercial devices; active clinical trials; alternate mechanisms of action (future of FUS). The second part of the session will compare HIFU to existing ionization radiation techniques. The difficulties in defining a clear concept of absorbed dose for HIFU will be discussed. Some of the technical challenges that HIFU faces will be described, with an emphasis on how the experience of radiation oncology physicists could benefit the field. Learning Objectives: Describe the basic physics and biology of HIFU, including treatment delivery and image guidance techniques. Summarize existing and emerging clinical applications and manufacturers for HIFU. Understand that thermal ablation with HIFU is likely the first of several applications of the technology Learn about some similarities and differences between HIFU and ionizing radiation in terms of physics and biological effects. Learn about some of the technical challenges HIFU faces that might benefit from the experience of radiation oncology physicists including treatment planning improvements, quality assurance procedures, and treatment risk analysis. David Schlesinger receives research support from Elekta Instruments, AB. Matt Eames is an employee of the Focused Ultrasound Foundation which supports research and clinical trials. Dr. Eames conducts research which is supported by the Focused Ultrasound Foundation.

60 APPLIED LIFE SCIENCES↗

Phase Mapper: Accelerating Materials Discovery with AI

From the stone age, to the bronze, iron age, and modern silicon age, the discovery and characterization of new materials has always been instrumental to humanity's progress and development. With the current pressing need to address sustainability challenges and find alternatives to fossil fuels, we look for solutions in the development of new materials that will allow for renewable energy. To discover materials with the required properties, materials scientists can perform high-throughput materials discovery, which includes rapid synthesis and characterization via X-ray diffraction (XRD) of thousands of materials. A central problem in materials discovery, the phase map identification problem, involves the determination of the crystal structure of materials from materials composition and structural characterization data. This analysis is traditionally performed mainly by hand, which can take days for a single material system. In this work we present Phase-Mapper, a solution platform that tightly integrates XRD experimentation, AI problem solving, and human intelligence for interpreting XRD patterns and inferring the crystal structures of the underlying materials. Phase-Mapper is compatible with any spectral demixing algorithm, including our novel solver, AgileFD, which is based on convolutive non-negative matrix factorization. AgileFD allows materials scientists to rapidly interpret XRD patterns, and incorporates constraints to capture prior knowledge about the physics of the materials as well as human feedback. With our system, materials scientists have been able to interpret previously unsolvable systems of XRD data at the Department of Energy’s Joint Center for Artificial Photosynthesis, including the Nb-Mn-V oxide system, which led to the discovery of new solar light absorbers and is provided as an illustrative example of AI-enabled high throughput materials discovery

Computer Science↗

Crossing transition in the EIC HSR with a resonance island jump scheme

The Resonance Island Jump (RIJ) scheme for transition crossing in the Hadron Storage Ring of the Electron-Ion Collider is radically new, and untested. Beam experiments in RHIC will be necessary if it becomes necessary to consider the RIJ scheme as a serious alternative to upgrading the first order linear jump scheme currently implemented in RHIC. This paper outlines the theoretical foundations of the RIJ scheme, and considers how a beam experiment in RHIC could be performed.

Accelerator Physics↗

Commercial Building Energy Asset Score Program Overview and Technical Protocol (Version 1.1)

The U.S. Department of Energy (DOE) is developing a voluntary national scoring system for commercial buildings to help building owners and managers assess a building’s energy-related systems independent of operations. The goal of the score is to facilitate cost-effective investment in energy efficiency improvements of commercial buildings. The system, known as the Commercial Building Energy Asset Score, will allow building owners and managers to compare their building infrastructure against peers and track building upgrades over time. The system will also help other building stakeholders (e.g., building investors, tenants, financiers, and appraisers) understand the relative efficiency of different buildings in a way that is independent from operations and occupancy. This report outlines the technical protocol used to generate the energy asset score, explains the scoring methodology, and provides additional details regarding the energy asset scoring tool. The alternative methods that were considered prior to developing the current approach are described in the Program Overview and Technical Protocol Version 1.0.

Building Energy Use↗

BISON Fuel Performance Analysis of IFA-796 Rod 3 & 4 and Investigation of the Impact of Fuel Creep

In order to improve the accident tolerance of light water reactor (LWR) fuel, alternative cladding materials have been proposed to replace the currently used zirconium (Zr)-based alloys. Of these materials, there is a particular focus on iron-chromiumaluminum (FeCrAl) alloys because they exhibit slower oxidation kinetics in high-temperature steam than Zr-alloys. This should decrease the energy release due to oxidation and slow cladding consumption in the presence of high temperature steam. These alloys should also exhibit increased “coping time” in the event of an accident scenario by improving the mechanical performance at high temperatures, allowing greater flexibility to achieve core cooling. As a continuation of the development of these alloys, in-reactor irradiation testing of FeCrAl cladded fuel rods has started. In order to provide insight on the possible behavior of these fuel rods as they undergo irradiation in the Halden Boiling Water Reactor, engineering analysis has been performed using FeCrAl material models implemented into the BISON fuel performance code. This milestone report provides an update on the ongoing development of modeling capability to predict FeCrAl cladding fuel performance and to provide an early look at the possible behavior of planned in-reactor FeCrAl cladding experiments. In particular, this report consists of two separate analyses. The first analysis consists of fuel performance simulations of IFA-796 rod 4 and two segments of rod 3. These simulations utilize previously implemented material models for the C35M FeCrAl alloy and UO2 to provide a bounding behavior analysis corresponding to variation of the initial fuel cladding gap thickness within the fuel rod. The second analysis is an assessment of the fuel and cladding stress states after modification of the fuel creep model that is currently implemented in the BISON fuel performance code. Effects from modifying the fuel creep model were identified for the BISON simulations of the IFA-796 rod 4 experiment, but show that varying the creep model (within the range investigated here) only provide a minimal increase in the fuel radius and maximum cladding hoop stress. Continued investigation of fuel behavioral models will include benchmarking the modified fuel creep model against available experimental data, as well as an investigation of the role that fuel cracking will play in the compliance of the fuel. Correctly calculating stress evolution in the fuel is key to assessing fuel behavior up to gap closure and the subsequent deformation of the cladding due to PCMI. The inclusion of frictional contact should also be investigated to determine the axial elongation of the fuel rods for comparison with data from this experiment.

11 NUCLEAR FUEL CYCLE AND FUEL MATERIALS↗

High Efficiency Heat Exchanger for High Temperature and High Pressure Applications

CompRex, LLC (CompRex) specializes in the design and manufacture of compact heat exchangers and heat exchange reactors for high temperature and high pressure applications. CompRex’s proprietary compact technology not only increases heat exchange efficiency by at least 25 % but also reduces footprint by at least a factor of ten compared to traditional shell-and-tube solutions of the same capacity and by 15 to 20 % compared to other currently available Printed Circuit Heat Exchanger (PCHE) solutions. As a result, CompRex’s solution is especially suitable for Brayton cycle supercritical carbon dioxide (sCO2) systems given its high efficiency and significantly lower capital and operating expenses. CompRex has already successfully demonstrated its technology and ability to deliver with a pilot-scale compact heat exchanger that was under contract by the Naval Nuclear Laboratory for sCO2 power cycle development. The performance tested unit met or exceeded the thermal and hydraulic specifications with measured heat transfer between 95 to 98 % of maximum heat transfer and temperature and pressure drop values all consistent with the modeled values. CompRex’s vision is to commercialize its compact technology and become the leading provider for compact heat exchangers and heat exchange reactors for various applications including Brayton cycle sCO2 systems. One of the limitations of the sCO2 Brayton power cycle is the design and manufacturing of efficient heat exchangers at extreme operating conditions. Current diffusion-bonded heat exchangers have limitations on the channel size through which the fluid travels, resulting in excessive solid material per heat exchanger volume. CompRex’s design allows for more open area and shorter fluid proximity for increased heat transfer efficiency while sustaining the structural integrity needed for the application. CompRex is developing a novel improvement to its current heat exchanger design where fluids are directed to alternating channels so that each fluid is fully surrounded by the opposing fluid. As compared to similar existing compact heat exchangers, the new design converts most secondary surface area to primary surface area, eliminating fin inefficiencies. CompRex requests that all technical information about the heat exchanger designs be protected as proprietary information. To honor that request, only non-proprietay summaries are included in this report.

47 OTHER INSTRUMENTATION↗

Thermo-mechanical analysis of SiC and FeCrAl cladding behavior under a loss-of- coolant accident

Alternative cladding materials have been proposed to replace the currently used zirconium (Zr)-based alloys, in order to improve the accident tolerance of light water reactor (LWR) fuel. Of these materials, there is a particular focus on iron-chromium-aluminum (FeCrAl) alloys and silicon carbide composite materials that exhibit much slower oxidation kinetics in high-temperature st eam than Zr-alloys. This behavior should decrease the energy release due to oxidation and allow the cladding to remain integral longer in the presence of high temperature steam, making accident mitigation more likely.

36 MATERIALS SCIENCE↗

Next Generation Robust Polarization Photocathodes for EIC

Cornell group developed and characterized robust photocathodes dedicated to generation of spin-polarized electrons by employing a thin protective activation layer of a robust material in place of the conventional cesiation, which is extremely prone to the damage by ions and chemical poisoning. Various thicknesses of Cs2Te and of other materials on III-V semiconductors were studied to understand their effect on the cathode longevity and the polarization state. These photocathodes, as well as new alternative materials, will be eventually tested with high beam current for their operational (lifetime) performance in the Cornell HV DC guns, including a brand- new photoemission high voltage gun that features a cryogenically cooled photocathode holder. The research conducted opens a new and robust way to reach the negative electron affinity for a large class of photocathodes specifically designed to maximize their accelerator performance. It particular, it benefits the future EIC by improving the lifetime available from spin-polarized electron photoemission sources.

43 PARTICLE ACCELERATORS↗

Resonance Island Jump theory for the HSR

The Resonance Island Jump (RIJ) scheme for transition crossing in HSR (or the CERN SPS [1, 2]) is radically new, and untested. Beam experiments in RHIC will be necessary if the RIJ scheme is to be considered as a serious alternative to upgrading the first order linear jump scheme currently implemented in RHIC [3]. This note outlines the planning and the theoretical foundations that are necessary for such a beam experiment, perhaps to be performed in 2024.

43 PARTICLE ACCELERATORS↗

Biodegradation Studies of Polyhydroxybutyrate and Polyhydroxybutyrate- co -Polyhydroxyvalerate Films in Soil

Due to increased environmental pressures, significant research has focused on finding suitable biodegradable plastics to replace ubiquitous petrochemical-derived polymers. Polyhydroxyalkanoates (PHAs) are a class of polymers that can be synthesized by microorganisms and are biodegradable, making them suitable candidates. The present study looks at the degradation properties of two PHA polymers: polyhydroxybutyrate (PHB) and polyhydroxybutyrate-co-polyhydroxyvalerate (PHBV; 8 wt.% valerate), in two different soil conditions: soil fully saturated with water (100% relative humidity, RH) and soil with 40% RH. The degradation was evaluated by observing the changes in appearance, chemical signatures, mechanical properties, and molecular weight of samples. Both PHB and PHBV were degraded completely after two weeks in 100% RH soil conditions and showed significant reductions in mechanical properties after just three days. The samples in 40% RH soil, however, showed minimal changes in mechanical properties, melting temperatures/crystallinity, and molecular weight over six weeks. By observing the degradation behavior for different soil conditions, these results can pave the way for identifying situations where the current use of plastics can be replaced with biodegradable alternatives.

36 MATERIALS SCIENCE↗

Geosynchronous platform definition study. Volume 3: Geosynchronous mission characteristics

The objectives of the study were to examine the nature of currently planned and new evolutionary geosynchronous programs, to analyze alternative ways of conducting missions, to establish concepts for new systems to support geosynchronous programs in an effective and economical manner, and to define the logistic support to carry out these programs. In order to meet these objectives, it was necessary to define and examine general geosynchronous mission characteristics and the potentially applicable electromagnetic spectrum characteristics. An organized compilation of these data is given with emphasis on the development and use of the data. Fundamental geosynchronous orbit time histories, mission profile characteristics, and delivery system characteristics are presented. In addition, electromagnetic spectrum utilization is discussed in terms of the usable frequency spectrum, the spectrum potentially available considering established frequency allocations, and the technology status as it affects the ability to operate within specific frequency bands.

Source record↗

Energy efficient transport technology: Program summary and bibliography

The Energy Efficient Transport (EET) Program began in 1976 as an element of the NASA Aircraft Energy Efficiency (ACEE) Program. The EET Program and the results of various applications of advanced aerodynamics and active controls technology (ACT) as applicable to future subsonic transport aircraft are discussed. Advanced aerodynamics research areas included high aspect ratio supercritical wings, winglets, advanced high lift devices, natural laminar flow airfoils, hybrid laminar flow control, nacelle aerodynamic and inertial loads, propulsion/airframe integration (e.g., long duct nacelles) and wing and empennage surface coatings. In depth analytical/trade studies, numerous wind tunnel tests, and several flight tests were conducted. Improved computational methodology was also developed. The active control functions considered were maneuver load control, gust load alleviation, flutter mode control, angle of attack limiting, and pitch augmented stability. Current and advanced active control laws were synthesized and alternative control system architectures were developed and analyzed. Integrated application and fly by wire implementation of the active control functions were design requirements in one major subprogram. Additional EET research included interdisciplinary technology applications, integrated energy management, handling qualities investigations, reliability calculations, and economic evaluations related to fuel savings and cost of ownership of the selected improvements.

Middleton, D. B.↗

Materials technology assessment for a 1050 K Stirling space engine design

An assessment of materials technology and proposed materials selection was made for the 1050 K (superalloy) Stirling Space Engine design. The objectives of this assessment were to evaluate previously proposed materials selections, evaluate the current state-of-the-art materials, propose potential alternate materials selections and identify research and development efforts needed to provide materials that can meet the stringent system requirements. This assessment generally reaffirmed the choices made by the contractor. However, in many cases alternative choices were described and suggestions for needed materials and fabrication research and development were made.

Scheuermann, Coulson M.↗

Requirements and designs for Mars Rover RTGs

A typical Rover mission, its requirements, the environment it imposes on the radionuclide thermoelectric generator (RTG), and a design approach for making the RTG operable in such an environment are described. Specific RTG designs for various thermoelectric element alternatives are presented. The results of studies show that current multifoil-insulated GPHS (general-purpose heat source) RTG and Mod-RTG designs can be modified to operate in an environment with an external atmosphere (e.g., Mars). This can be done while the helium generated by the fuel's alpha decay is vented to the external atmosphere. The use of novel selective vents and high-capacity getters is not required. The Rover RTGs can be built from standard, proven GPHS modules and standard SiGe unicouples or SiGe/GaP multicouples, using demonstrated thermoelectric material performance parameters. Rover's 500-W power requirement can be satisfied with two 250-W or four 125-W RTGs, whose sizes are compatible with currently envisaged Rover designs. An auxiliary cooling loop (e.g., water and antifreeze) will be required to cool the RTG while it is within the Rover's aeroshell during launch and transit to Mars.

Schock, A.↗

Kate's Model Verification Tools

Kennedy Space Center's Knowledge-based Autonomous Test Engineer (KATE) is capable of monitoring electromechanical systems, diagnosing their errors, and even repairing them when they crash. A survey of KATE's developer/modelers revealed that they were already using a sophisticated set of productivity enhancing tools. They did request five more, however, and those make up the body of the information presented here: (1) a transfer function code fitter; (2) a FORTRAN-Lisp translator; (3) three existing structural consistency checkers to aid in syntax checking their modeled device frames; (4) an automated procedure for calibrating knowledge base admittances to protect KATE's hardware mockups from inadvertent hand valve twiddling; and (5) three alternatives for the 'pseudo object', a programming patch that currently apprises KATE's modeling devices of their operational environments.

Morgan, Steve↗