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At least 1,387 records · Page 77
All sourcesNASA NTRSDOE OSTI
NASA NTRS1977

Studies of orbital Eoetvoes experiments

A direct force-balance technique was analyzed for carrying out the Eoetvoes experiment in space, which is intended to give sufficient sensitivity to allow investigation of the gravitational interactions of energy stored in the weak interaction. The heart of experiment is an exceedingly sensitive dual accelerometer, containing two proof masses constructed of the materials whose Eoetvoes ratio is to be compared. For use in development of the accelerometer, a magnetic microbalance is proposed in which the weight of the proof mass is supported by magnetic forces which vary very slowly with the proof mass position. It is shown that at least two different mechanizations of the magnetic suspension may be feasible.

Chapman, P. K.↗
NASA NTRS1977

Vectorcardiographic results from Skylab medical experiment M092: Lower body negative pressure

Electrocardiographic interval changes suggesting effects of increased vagal tone were observed early in some Gemini crewmembers. Preflight versus postflight amplitude differences appeared in electrocardiograms of several of the early Apollo crewmembers. In preflight and postflight crew evaluations of the last three Apollo flights, quantitative postflight vectorcardiographic changes were for the first time determined in American space crews. Changes not considered related to heart rate were mainly those of increased P and QRS vector magnitudes and orientation shifts. But since most of these postflight findings resembled those observed with the orthostatic stress of lower body negative pressure, it was inferred then that upon their return from space, these Apollo astronauts exhibited exaggerated responses to orthostasis in the vectorcardiogram as well as in measures of cardiovascular hemodynamics.

Hoffler, G. W.↗
NASA NTRS1977

Vectorcardiograph

A system for quantitating the cardiac electrical activity of Skylab crewmen was required for three medical experiments (M092, Lower Body Negative Pressure; M171, Metabolic Activity; and M093, In-flight Vectorcardiogram) designed to evaluate the effects of space flight on the human cardiovascular system. A Frank lead vectorcardiograph system was chosen for this task because of its general acceptability in the scientific community and its data quantification capabilities. To be used effectively in space flight, however, the system had to meet certain other requirements. The system was required to meet the specifications recommended by the American Heart Association. The vectorcardiograph had to withstand the extreme conditions of the space environment. The system had to provide features that permitted ease of use in the orbital environment. The vectorcardiograph system performed its intended function throughout all the Skylab missions without a failure. A description of this system follows.

Lintott, J.↗
NASA NTRS1976

Potential biomedical applications of ion beam technology

Electron bombardment ion thrusters used as ion sources have demonstrated a unique capability to vary the surface morphology of surgical implant materials. The microscopically rough surface texture produced by ion beam sputtering of these materials may result in improvements in the biological response and/or performance of implanted devices. Control of surface roughness may result in improved attachment of the implant to soft tissue, hard tissue, bone cement, or components deposited from blood. Potential biomedical applications of ion beam texturing discussed include: vascular prostheses, artificial heart pump diaphragms, pacemaker fixation, percutaneous connectors, orthopedic prosthesis fixation, and dental implants.

Banks, B. A.↗
NASA NTRS1976

Cardiorespiratory deconditioning with static and dynamic leg exercise during bed rest

Results are presented for an experimental study designed to compare the effects of heavy static and dynamic exercise training during 14 days of bed rest on the cardiorespiratory responses to submaximal and maximal exercise performed by seven healthy men aged 19-22 yr. The parameters measured were submaximal and maximal oxygen uptake, minute ventilation, heart rate, and plasma volume. The results indicate that exercise alone during bed rest reduces but does not eliminate the reduction in maximal oxygen uptake. An additional positive hydrostatic effect is therefore necessary to restore maximal oxygen uptake to ambulatory control levels. The greater protective effect of static exercise on maximal oxygen uptake is probably due to a greater hydrostatic component from the isometric muscular contraction. Neither the static nor the dynamic exercise training regimes are found to minimize the changes in all the variables studied, thereby suggesting a combination of static and dynamic exercises.

Stremel, R. W.↗
NASA NTRS1976

A role for glucose in hypothermic hamsters

Hypothermic hamsters at a rectal temperature of 7 C showed a fivefold increase in survival times from 20 to 100.5 hr when infused with glucose which maintained a blood level at about 45 mg/100 ml. A potential role for osmotic effects of the infusion was tested and eliminated. There was no improvement in survival of 3-O-methylglucose or dextran 40-infused animals. The fact that death eventually occurs even in the glucose-infused animal after about 4 days and that oxygen consumption undergoes a slow decrement in that period suggests that hypothermic survival is not wholly substrate limited. Radioactive tracer showed that localization of the C-14 was greatest in brain tissue and diaphragm, intermediate in heart and kidney, and lowest in skeletal muscle and liver. The significance of the label at sites important to respiration and circulation was presented.

Resch, G. E.↗
NASA NTRS1976

Methods and new approaches to the calculation of physiological parameters by videodensitometry

A complex system featuring a video-camera connected to a video disk, cine (medical motion picture) camera and PDP-9 computer with various input/output facilities has been developed. This system enables the performance of quantitative analysis of various functions recorded in clinical studies. Several studies are described, such as heart chamber volume calculations, left ventricle ejection fraction, blood flow through the lungs and also the possibility of obtaining information about blood flow and constrictions in small cross-section vessels

Kedem, D.↗
NASA NTRS1977

Exercise, dietary obesity, and growth in the rat

Experiments were conducted on weanling male rats 35 days old and weighing about 100 g to determine how endurance-type exercise and high-fat diet administered during growth influence body mass and composition. The animals were divided into four weight-matched groups of 25 animals each: group I - high-fat diet, exercised; group II - chow, exercised; group III - high-fat diet, sedentary; and group IV - chow, sedentary. During growth, masses of water, muscle and skin increased as functions of body size; bone as a function of age; and heart, liver, gut, testes, and CNS were affected by combinations of size, age, activity, and diet. Major conclusions are that growth in body size is expressed more precisely with fat-free body mass (FFBM), that late rectilinear growth is probably attributable to fat accretion, and that the observed influences on FFBM of exercise and high-fat diet are obtained only if the regimen is started at or before age 5-7 weeks.

Pitts, G. C.↗
NASA NTRS1977

Ion-beam-sputter modification of the surface morphology of biological implants

The surface chemistry and texture of materials used for biological implants may significantly influence their performance and biocompatibility. Recent interest in the microscopic control of implant surface texture has led to the evaluation of ion-beam sputtering as a potentially useful surface roughening technique. Ion sources, similar to electron-bombardment ion thrusters designed for propulsive applications, are used to roughen the surfaces of various biocompatible alloys or polymer materials. These materials are typically used for dental implants, orthopedic prostheses, vascular prostheses, and artificial heart components. Masking techniques and resulting surface textures are described along with progress concerning evaluation of the biological response to the ion-beam-sputtered surfaces.

Weigand, A. J.↗
NASA NTRS1977

Cardiovascular responses of men and women to lower body negative pressure

Changes in blood flow and blood redistribution were measured by impedance plethysmography in the pelvic and leg regions of six male and four female subjects during three 5-min exposures to -20, -40, and -60 mm Hg lower body negative pressure (LBNP). Female subjects demonstrated significantly higher mean heart rate and lower leg blood flow indices than the male subjects during the recumbent control periods. Men had slightly higher mean resting systolic and diastolic blood pressures and higher mean control pelvic blood indices. Women demonstrated significantly less blood pooling in the legs and slightly less in the pelvic region than the men. All of the 18 tests with male subjects at -60 mm Hg were completed without initial signs of syncope, while only two of the tests with women were completed successfully without the subject exhibiting presyncopal conditions. Results indicate that impedance plethysmography can be used to measure segmental cardiovascular responses during LBNP and that females may be less tolerant to -60 mm Hg LBNP than males.

Montgomery, L. D.↗
NASA NTRS1977

Mechanisms responsible for decreased glomerular filtration in hibernation and hypothermia

Measurements of blood pressure, heart rate, red blood cell and plasma volumes, and relative distribution of cardiac output were made on hibernating and hypothermic adult male and female golden hamsters weighing 120-140 g to study the mechanisms underlying the elimination or marked depression of renal function in hibernation and hypothermia. The results suggest that the elimination or marked depression in renal function reported in hibernation and hypothermia may partly be explained by alterations in cardiovascular system function. Renal perfusion pressure which decreases nearly 60% in both hibernation and hypothermia and a decrease in plasma volume of roughly 35% in the hypothermic animal might both be expected to markedly alter glomerular function.

Tempel, G. E.↗
NASA NTRS1977

Diurnal rhythms of visual accommodation and blink responses - Implication for flight-deck visual standards

Possible 24-h variations in accommodation responses were investigated. A recently developed servo-controlled optometer and focus stimulator were used to obtain monocular accommodation response data on four college-age subjects. No 24-h rhythm in accommodation was shown. Heart rate and blink rate also were measured and periodicity analysis showed a mean 24-h rhythm for both; however, blink rate periodograms were significant for only two of the four subjects. Thus, with the qualifications that college students were tested instead of pilots and that they performed monocular laboratory tasks instead of binocular flight-deck tasks, it is concluded that 24-h rhythms in accommodation responses need not be considered in setting visual standards for flight-deck tasks.

Murphy, M. R.↗
NASA NTRS1977

A digital goniometer for VOR

A new VOR (VHF omni-range) goniometer design which promises to improve the reliability and maintainability of the VOR ground station is described. The heart of the new concept is the use of two digital phase shifters to produce the rotating figure-of-eight pattern of conventional VOR. Using digital circuits, the goniometer adjustments and calibration reduce to timing adjustments of binary signals. A common clock used for timing the digital phase shifters also synchronizes the 30 Hz modulation of the 9.96 kHz reference.

Meer, S. A.↗
NASA NTRS1977

A portable personal cooling system for mine rescue operations

Design of a portable personal cooling system to reduce physiological stress in high-temperature, high-humidity conditions is discussed. The system, based on technology used in the thermal controls of space suits, employs a combination of head and thoracic insulation and cooling through a heat sink unit. Average metabolic rates, heart rates, rectal temperature increase and sweat loss were monitored for test subjects wearing various configurations of the cooling system, as well as for a control group. The various arrangements of the cooling garment were found to provide significant physiological benefits; however, increases in heat transfer rate of the cooling unit and more effective insulation are suggested to improve the system's function.

Webbon, B.↗
NASA NTRS1977

Cardiorespiratory responses to exercise after bed rest in men and women

The purpose of this study was to compare cardiorespiratory responses of men and women to submaximal and maximal workloads before and after bed rest (BR). Fifteen male college students (19-23 yr) and eight female nurses (23-34 yr) underwent 14 d and 17 d, respectively, of bed rest. The maximal work capacity test was performed in the supine position on a bicycle ergometer just before and immediately after bed rest. Compared with pre-BR values, after bed rest the maximal ventilatory volume was essentially unchanged in the men (+1.8%) and women (+2.3%), but maximal heart rate was elevated from 185 to 193 b/min (+4.3%) in the men and from 181 to 187 b/min (3.3%) in the women. Mean corpuscular volume was unchanged in both groups pre- and post-bed rest. It is concluded that the proportional deterioration in maximal VO2 following prolonged bed rest was essentially the same in young men and women.

Convertino, V. A.↗
NASA NTRS1979

Hand-held vital-signals monitor

Complete miniaturized physiological vital-signs monitor displays body temperature, heart rate, and breath rate, and has provision to display blood-pressure data fed from external circuitery.

Rinard, G. A.↗
NASA NTRS1979

Hybrid heart/breath-rate processor

Single hybrid circuit converts time between pulses from ECG signal conditioner of breath-rate signal conditioner to determine heart-rate of respiration-rate output of hand-held vital signs monitor.

Rinard, G. A.↗
NASA NTRS1977

Cardiovascular studies using the chimpanzee (Pan troglodytes)

Despite the phylogenetic similarities between chimpanzees and man, there exists a paucity of reliable data on normal cardiovascular function and the physiological responses of the system to standard interventions. Totally implanted biotelemetry systems or hardwire analog techniques were used to examine the maximum number of cardiovascular variables which could be simultaneously monitored without significantly altering the system's performance. This was performed in order to acquire base-line data not previously obtained in this species, to determine cardiovascular response to specific forcing functions such as ventricular pacing, drug infusions, and lower body negative pressure. A cardiovascular function profile protocol was developed in order to adjust independently the three major factors which modify ventricular performance, namely, left ventricular performance, left ventricular preload, afterload, and contractility. Cardiac pacing at three levels above the ambient rate was used to adjust end diastolic volume (preload). Three concentrations of angiotensin were infused continuously to evaluate afterload in a stepwide fashion. A continuous infusion of dobutamine was administered to raise the manifest contractile state of the heart.

Hinds, J. E.↗