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At least 1,369 records · Page 76

National Virtual Biotechnology Laboratory: Report on Rapid R&D Solutions to the COVID-19 Crisis

With funding from the CARES Act, the U.S Department of Energy (DOE) established the National Virtual Biotechnology Laboratory (NVBL) in March 2020 to address key challenges associated with the COVID-19 crisis. NVBL brought together the broad scientific and technical expertise and resources of DOE’s 17 national laboratories to help tackle medical supply short ages, discover potential drugs to fight the virus, develop and validate COVID-19 testing methods, model disease spread and impact across the nation, and understand virus transport in buildings and the environment. National laboratory resources leveraged for this effort include a suite of world-leading user facilities broadly available to the research community, such as light and neutron sources, nanoscale science research centers, sequencing and biocharacterization facilities, and high-performance computing facilities. Within months, NVBL teams produced innovations in materials and advanced manufacturing that mitigated shortages in test kits and personal protective equipment (PPE), creating nearly 1,000 new jobs. They used DOE’s high-performance computers and light and neutron sources to identify promising candidates for antibodies and antivirals that universities and drug companies are now evaluating. NVBL researchers also developed new diagnostic targets and sample collection approaches, and supported U.S. Food and Drug Administration (FDA), Centers for Disease Control and Prevention (CDC), and U.S. Department of Defense (DoD) efforts to establish national guidelines used in administering millions of tests. Researchers used artificial intelligence and high-performance computing to produce near-real-time data analysis to forecast disease transmission, stress on public health infrastructure, and economic impact, which supported decision-makers at the local, state, and national levels. NVBL teams also studied how to control indoor virus movement to minimize uptake and protect human health. NVBL’s accomplishments demonstrate not only the powerful resource represented by DOE’s national laboratories working together to meet national needs, but also the effectiveness of the integrated NVBL framework for rapidly responding to emergencies with research and development (R&D) solutions. As the fight against COVID continues, sustained efforts are needed to confront this pandemic as well as future threats. Examples include: 1) Establishing “supply chains on demand” to meet emergency production needs by leveraging the materials and manufacturing expertise of DOE national laboratories and developing advances in electronics, sensing, robotics, and automation capabilities; 2) Improving the speed and robustness of drug discovery by integrating experimental platforms with DOE’s computational and experimental user facilities, which provide unique resources to support the discovery of high-potential therapeutic agents; 3) Protecting public, environmental, and animal health by developing new testing protocols and instrumentation adaptable to diverse sample types (both physiological and environmental) to quickly detect a wide range of pathogens and monitor other biorisks; 4) Supporting near-real-time data needs of decision-makers at the local, regional, state, and national levels by advancing data curation, analysis, and modeling using artificial intelligence and new data science tools for managing and evaluating large diverse datasets; 5) Harnessing DOE’s expertise in environmental modeling to design rooms and air handling for offices, classrooms, restaurants, and other structures to minimize biorisk transmissions. Going forward, NVBL is poised to apply the unique capabilities and expertise of the national laboratory complex to future national and international emergencies, both natural and engineered. Through this framework, the Office of Science will continue to be an integral component of agency wide efforts to prepare for and respond to biorisks and other crises.

42 ENGINEERING↗

Climatic, eustatic, and tectnoic controls on Quarternary deposits and landforms, Red Sea coast, Egypt

The degree to which local climatic variations, eustatic sea level fluctuations, and tectonic uplift have influenced the development of Quaternary marine and fluvial landforms and deposits along the Red Sea coast, Eastern Desert, was investigated using a combination of remote sensing and field data, age determinations of corals, and numerical simulations. False color composites generated from Landsat Thematic Mapper and SPOT image data, digital elevation models derived from sterophotogrammetric analysis of SPOT data, and field observations document that a approximately 10-km wide swath inland from the coast is covered in many places with coalescing alluvial fans of Quaternary age. Wadis cutting through the fans exhibit several pairs of fluvial terraces, and wadi walls expose alluvium interbedded with corraline limestone deposits Further, three distinct coral terraces are evident along the coatline. Climatic, eustatic, and tectonic uplift controls on the overall system were simulated using a cellular automata algorithm with the following characteristics: (1) uplift as a function of position and time, as defined by the elevations and ages of corals; (2) climatic variations driven by insolation changes associated with Milankovitch cycles; (3) sea level fluctuations based on U/Th ages of coral terraces and eustatic data; and (4) parametrized fluvial erosion and deposition. Results imply that the fans and coralline limestones were generated in a setting in which the tectonic uplift rate decreased over the Quarternary to negligible values at present. Coralline limestones formed furing eustatic highstands when alluvium was trapped uspstream and wadis filled with debris. During lowstands, wadis cut into sedimentary deposits; coupled with continuing uplift, fans were dissected, leaving remnant surfaces, and wadi-related terraces were generated by down cutting. Only landforms from the past three to four eustatic sea level cycles (i.e., approximately 300 to 400 kyr) are likely to have survived erosion and deposition associated with fluvial processes.

Arvidson, Raymond↗

Protein crystal growth in low gravity

This Final Technical Report for NASA Grant NAG8-774 covers the period from April 27, 1989 through December 31, 1992. It covers five main topics: fluid flow studies, the influence of growth conditions on the morphology of isocitrate lyase crystals, control of nucleation, the growth of lysozyme by the temperature gradient method and graphoepitaxy of protein crystals. The section on fluid flow discusses the limits of detectability in the Schlieren imaging of fluid flows around protein crystals. The isocitrate lyase study compares crystals grown terrestrially under a variety of conditions with those grown in space. The controlling factor governing the morphology of the crystals is the supersaturation. The lack of flow in the interface between the drop and the atmosphere in microgravity causes protein precipitation in the boundary layer and a lowering of the supersaturation in the drop. This lowered supersaturation leads to improved crystal morphology. Preliminary experiments with lysozyme indicated that localized temperature gradients could be used to nucleate crystals in a controlled manner. An apparatus (thermonucleator) was designed to study the controlled nucleation of protein crystals. This apparatus has been used to nucleate crystals of materials with both normal (ice-water, Rochelle salt and lysozyme) and retrograde (horse serum albumin and alpha chymotrypsinogen A) solubility. These studies have lead to the design of an new apparatus that small and more compatible with use in microgravity. Lysozyme crystals were grown by transporting nutrient from a source (lysozyme powder) to the crystal in a temperature gradient. The influence of path length and cross section on the growth rate was demonstrated. This technique can be combined with the thermonucleator to control both nucleation and growth. Graphoepitaxy utilizes a patterned substrate to orient growing crystals. In this study, silicon substrates with 10 micron grooves were used to grow crystals of catalase, lysozyme and canavalin. In all cases, the crystals grew oriented to the substrate. The supersaturation needed for nucleation and growth was lower on the patterned substrates. In some cases, isolated, large crystals were grown.

Feigelson, Robert S.↗

Global stochastic optimization of stellarator coil configurations

In the construction of a stellarator, the manufacturing and assembling of the coil system is a dominant cost. These coils need to satisfy strict engineering tolerances, and if those are not met the project could be cancelled as in the case of the National Compact Stellarator Experiment (NCSX) project. Therefore, our goal is to find coil configurations that increase construction tolerances without compromising the performance of the magnetic field. In this paper, we develop a gradient-based stochastic optimization model which seeks robust stellarator coil configurations in high dimensions. In particular, we design a two-step method: first, we perform an approximate global search by a sample efficient trust-region Bayesian optimization; second, we refine the minima found in step one with a stochastic local optimizer. To this end, we introduce two stochastic local optimizers: BFGS applied to the sample average approximation; and Adam, equipped with a control variate for variance reduction. Numerical simulations performed on a W7-X-like coil configuration demonstrate that our global optimization approach finds a variety of promising local solutions at less than 0.1% of the cost of previous work, which considered solely local stochastic optimization.

70 PLASMA PHYSICS AND FUSION TECHNOLOGY↗

Adaptive Attitude Control System For Space Station

Report presents theoretical foundation for attitude control system for proposed Space Station Freedom in orbit around Earth. Intended to maintain space station in torque equilibrium with designated axes of its structure aligned with local vertical, local along-trajectory horizontal, and local across-trajectory horizontal axes, respectively. System required to provide desired combination of control performance and stability in presence of disturbances (e.g., variations in masses of payloads, movements of astronauts and equipment, atmospheric drag, gravitational anomalies, and interactions with docking spacecraft).

Boussalis, Dhemetrios↗

Modeling and control for vibration suppression of a flexible smart structure

Theoretical and experimental results of the modeling and control of a flexible ribbed antenna are presented. The antenna consists of eight flexible ribs which constitutes a smart antenna in the sense that the actuator and sensors are an integral part of the structure. The antenna exhibits closely space and repeated modes, thus multi-input multi-output (MIMO) control is necessary for controllability and observability of the structure. The structure also exhibits mode localization phenomenon and contains post buckled members making an accurate finite element model of the structure difficult to obtain. An identified MIMO minimum order model of the antenna is synthesized from identified single-input single-output (SISO) transfer functions curve fit in the frequency domain. The identified model is used to design a positive position feedback (PPF) controller that increases damping in all of the modes in the targeted frequency range. Due to the accuracy of the open loop model of the antenna, the closed loop response predicted by the identified model correlates well wtih experimental results.

Dosch, J.↗

Numerical investigation of the control of the secondary instability process in boundary layers

A numerical model has been developed for investigating boundary layer transition control for a flat plate boundary layer. Active control of a periodically forced boundary layer in an incompressible fluid is studied using surface heating techniques. The spatially evolving boundary layer is simulated. The Navier-Stokes and energy equations are integrated using a fully implicit finite difference/spectral method. Temperature perturbations are introduced locally along finite heater strips to directly attenuate the instability waves in the flow. A feedback control loop is employed in which a downstream sensor is used to monitor wall shear stress fluctuations. Active control of small amplitude two-dimensional and three-dimensional disturbances is numerically simulated. With proper phase control, in-phase reinforcement and out-of-phase attenuation are demonstrated. A receptivity study of the localized temperature perturbations is made. It is shown that narrow heater strips are more receptive in that they maximize the amplitude level of the disturbances in the flow. Active control of the early stages of the fundamental breakdown process is also numerically simulated. Control is achieved with either two-dimensional or three-dimensional control inputs.

Kral, L. D.↗

ISS And Space Environment Interactions Without Operating Plasma Contactor

The International Space Station (ISS) will be the largest, highest power spacecraft placed in orbit. Because of this the design of the electrical power system diverged markedly from previous systems. The solar arrays will operate at 160 V and the power distribution voltage will be 120 V. The structure is grounded to the negative side of the solar arrays so under the right circumstances it is possible to drive the ISS potential very negative. A plasma contactor has been added to the ISS to provide control of the ISS structure potential relative to the ambient plasma. The ISS requirement is that the ISS structure not be greater than 40 V positive or negative of local plasma. What are the ramifications of operating large structures with such high voltage power systems? The application of a plasma contactor on ISS controls the potential between the structure and the local plasma, preventing degrading effects. It is conceivable that there can be situations where the plasma contactor might be non-functional. This might be due to lack of power, the need to turn it off during some of the build-up sequences, the loss of functionality for both plasma contactors before a replacement can be installed, similar circumstances. A study was undertaken to understand how important it is to have the contactor functioning and how long it might be off before unacceptable degradation to ISS could occur. The details of interaction effects on spacecraft have not been addressed until driven by design. This was true for ISS. If the structure is allowed to float highly negative impinging ions can sputter exposed conductors which can degrade the primary surface and also generate contamination due to the sputtered material. Arcing has been known to occur on solar arrays that float negative of the ambient plasma. This can also generate electromagnetic interference and voltage transients. Much of the ISS structure and pressure module surfaces exposed to space is anodized aluminum. The anodization thickness is very thin to provide the required solar absorptance and emittance. For conditions where ISS structure can charge negative a large percentage of the array voltage, the dielectric strength of this layer is low, and dielectric breakdown (arcing) can occur. The energy stored capacitively in the structure can be delivered to the arc. The mechanisms by which this energy is delivered and how much of the energy is available hasn't been fully quantified. Questions have been raised regarding the possibility of whether a sustained arc might result due to current collected by the solar arrays from local plasma. It was postulated that even if dielectric breakdown didn't occur, impacts due to micrometeoroids and space debris could penetrate thin layers of dielectric on ISS and initiate an arc due to the coupling provided by the dense local plasma produced by the impact. This was proven in experiments conducted jointly by MSFC and Auburn University. A target chamber with a simulated ionospheric plasma and a biased, anodized aluminum plate and a 1-microfarad capacitor was used. The plate was then impacted by 75-micron particles accelerated to orbital velocity. Arc discharges were sustained for higher voltages but a threshold appears below which no discharge was initiated. Most items without an exposed power system will float electrically near the local plasma potential. This is true of the Space Shuttle, an Astronaut on EVA, and similar items. The structure of ISS might be at a large negative voltage. Therefore, capacitively stored energy can be transferred during docking, installing external boxes and equipment and Astronaut contact with ISS structure. The circumstances of when this can happen and the resulting effects are evaluated in this study. Also, a crewmember on EVA might be in the vicinity of an arc. All safety aspects of such an encounter including charging, molten particles from the arc site and EMI have been evaluated. This paper will report on the total results of this study focussed on the 4A configuration, scheduled to be complete in November, 2000. Interactions such as arcing, debris induced arcs, sustained arcs, sputtering, contamination from sputtering and arcing, docking interactions and Astronaut safety issues will all be addressed.

Carruth, M. R., Jr.↗

ISS and Space Environment Interactions in Event of Plasma Contactor Failure

The International Space Station (ISS), illustrated in Figure 1, will be the largest, highest power spacecraft placed in orbit. Because of this the design of the electrical power system diverged markedly from previous systems. The solar arrays will operate at 160 V and the power distribution voltage will be 120 V. The structure is grounded to the negative side of the solar arrays so under the right circumstances it is possible to drive the ISS potential very negative. A plasma contactor has been added to the ISS to provide control of the ISS structure potential relative to the ambient plasma. The ISS requirement is that the ISS structure not be greater than 40 V positive or negative of local plasma. What are the ramifications of operating large structures with such high voltage power systems? The application of a plasma contactor on ISS controls the potential between the structure and the local plasma, preventing degrading effects. It is conceivable that there can be situations where the plasma contactor might be non-functional. This might be due to lack of power, the need to turn it off during some of the build-up sequences, the loss of functionality for both plasma contactors before a replacement can be installed, and similar circumstances. A study was undertaken to understand how important it is to have the contactor functioning and how long it might be off before unacceptable degradation to ISS could occur.

Carruth, M. R., Jr.↗

Prediction of forces and moments for flight vehicle control effectors: Workplan

Two research activities directed at hypersonic vehicle configurations are currently underway. The first involves the validation of a number of classical local surface inclination methods commonly employed in preliminary design studies of hypersonic flight vehicles. Unlike studies aimed at validating such methods for predicting overall vehicle aerodynamics, this effort emphasizes validating the prediction of forces and moments for flight control studies. Specifically, several vehicle configurations for which experimental or flight-test data are available are being examined. By comparing the theoretical predictions with these data, the strengths and weaknesses of the local surface inclination methods can be ascertained and possible improvements suggested. The second research effort, of significance to control during take-off and landing of most proposed hypersonic vehicle configurations, is aimed at determining the change due to ground effect in control effectiveness of highly swept delta planforms. Central to this research is the development of a vortex-lattice computer program which incorporates an unforced trailing vortex sheet and an image ground plane. With this program, the change in pitching moment of the basic vehicle due to ground proximity, and whether or not there is sufficient control power available to trim, can be determined. In addition to the current work, two different research directions are suggested for future study. The first is aimed at developing an interactive computer program to assist the flight controls engineer in determining the forces and moments generated by different types of control effectors that might be used on hypersonic vehicles. The first phase of this work would deal in the subsonic portion of the flight envelope, while later efforts would explore the supersonic/hypersonic flight regimes. The second proposed research direction would explore methods for determining the aerodynamic trim drag of a generic hypersonic flight vehicle and ways in which it can be minimized through vehicle design and trajectory optimization.

Maughmer, Mark D.↗

Sea ice and atmospheric circulation shape the high-latitude lapse rate feedback

Abstract Arctic amplification of anthropogenic climate change is widely attributed to the sea-ice albedo feedback, with its attendant increase in absorbed solar radiation, and to the effect of the vertical structure of atmospheric warming on Earth’s outgoing longwave radiation. The latter lapse rate feedback is subject, at high latitudes, to a myriad of local and remote influences whose relative contributions remain unquantified. The distinct controls on the high-latitude lapse rate feedback are here partitioned into “upper” and “lower” contributions originating above and below a characteristic climatological isentropic surface that separates the high-latitude lower troposphere from the rest of the atmosphere. This decomposition clarifies how the positive high-latitude lapse rate feedback over polar oceans arises primarily as an atmospheric response to local sea ice loss and is reduced in subpolar latitudes by an increase in poleward atmospheric energy transport. The separation of the locally driven component of the high-latitude lapse rate feedback further reveals how it and the sea-ice albedo feedback together dominate Arctic amplification as a coupled mechanism operating across the seasonal cycle.

54 ENVIRONMENTAL SCIENCES↗

Local Estimators for Spacecraft Formation Flying

A formation estimation architecture for formation flying builds upon the local information exchange among multiple local estimators. Spacecraft formation flying involves the coordination of states among multiple spacecraft through relative sensing, inter-spacecraft communication, and control. Most existing formation flying estimation algorithms can only be supported via highly centralized, all-to-all, static relative sensing. New algorithms are needed that are scalable, modular, and robust to variations in the topology and link characteristics of the formation exchange network. These distributed algorithms should rely on a local information-exchange network, relaxing the assumptions on existing algorithms. In this research, it was shown that only local observability is required to design a formation estimator and control law. The approach relies on breaking up the overall information-exchange network into sequence of local subnetworks, and invoking an agreement-type filter to reach consensus among local estimators within each local network. State estimates were obtained by a set of local measurements that were passed through a set of communicating Kalman filters to reach an overall state estimation for the formation. An optimization approach was also presented by means of which diffused estimates over the network can be incorporated in the local estimates obtained by each estimator via local measurements. This approach compares favorably with that obtained by a centralized Kalman filter, which requires complete knowledge of the raw measurement available to each estimator.

Fathpour, Nanaz↗

Adaptive simulations enable computational design of electron beam processing of nanomaterials with supersonic micro-jet precursor

Focused Electron Beam Induced Processing (FEBIP) is a powerful tool for the “direct-write” of nanomaterials with the possibility of atomistic control on suspended 2D material substrates. FEBIP capabilities have been significantly expanded by using a localized jet-based delivery of precursors, and especially when a thermally energized supersonic micro-jet enhances the delivery of mass flux along with controlling the far-from-equilibrium thermodynamic state of adsorbed adatoms. The possibilities of growing nanomaterials with “dialed-in” composition with ultra-high growth rates and aspect ratios up to 100:1 have been demonstrated using the supersonic micro-jet-FEBIP. Bringing this scientific discovery to the level of maturity required for practical applications in additive nanomanufacturing requires simulation tools that are capable of capturing the complex flow physics of micro-jet-substrate interactions that bridge a wide range of flow regimes from the high-density gas micro-jet expanding into the vacuum environment of FEBIP. To address this significant computational challenge, a new approach has been developed and described in this work for a multiscale adaptive DSMC (Direct Simulation Monte Carlo) algorithm to predict the micro-jet gas dynamics in an FEBIP environment, spanning the full range of flow regimes from low Knudsen (Kn) number O(0.01) continuum flow to high Kn of O(10) for the molecular flow within a unified computational framework. Here, the fundamental principles of the adaptive DSMC algorithm are described, its viability as a DSMC technique is demonstrated, and computational improvements for the benchmark cases are discussed in the context of advancing 3D nanofabrication with FEBIP. Ultimately, combining the first principle simulations via adaptive DSMC with the complementary experimental data will enable the creation of the powerful CAD tools for in silico design and optimal operation of micro-jet-FEBIP.

36 MATERIALS SCIENCE↗

Institutional and Policy Landscape for Solar-Plus-Storage Deployment by Electric Cooperatives

As co-location with battery storage has become a significant solar project-design trend across the United States, policies at all levels have started to adjust. Generally, these policies address battery storage development in major, urban markets, served by large investor-owned utilities (IOUs). Yet all kinds of utilities nationwide are seeking ways to tap into the fast-growing battery storage market, and they are all stakeholders in the federal, state, and local policies that impact the storage market's development. The electric cooperative sector, which includes some 830 distribution utilities and 63 generating and transmission (G&T) utilities across a mostly rural landscape, is no exception. It is impacted by federal, state, and local government policy requirements and incentives, as well as by policies that are controlled by the sector's own institutions. The objective of this paper is to identify and discuss the various policy and institutional factors that are relevant to the electric cooperative sector, and especially to local, distribution-level electric cooperatives (co-ops) that may be interested in procuring energy storage. Given this, the paper is largely written from the local co-op perspective. It also may be useful to wholesale G&T cooperatives. Other parties that may find the paper useful include storage developers, who are often unfamiliar with co-ops; local and state policymakers addressing policy options for this sector, and local renewable or storage stakeholders, who wish to understand the policy landscape affecting their local utility. Although co-op energy storage programs may tap customer-side batteries, this examination is focused on utility-side "front of the meter" projects and the policy issues they raise.

14 SOLAR ENERGY↗

JPL space station telerobotic engineering prototype development: Advanced telerobotics system technology

The objective of the Advanced Telerobotics System Technology Task is to develop/prototype advanced telerobotics supervisory and shared control to enhance Intra-Vehicular Activity (IVA) teleoperation in the Space Station. The technology provides enhanced telerobotics capabilities while operating within the expected constraints of computation limitations, time delay, and bus bandwidth. A local site operator interface has also been developed for specifying teleoperation and shared control modes as well as supervised autonomous macros for execution at the remote site. The primary objective of the task is to transfer the advanced technology to appropriate flight centers to enhance the baseline Station capabilities.

Backes, Paul G.↗

Radarclinometry

A general theory based on the implicit mathematical determinacy, and a corresponding algorithm, are developed to derive topographic maps from radar images as photometric arrays. Starting from a control profile, the theory produces topography by an area integration of radar brightness, and the control profile is formed under the assumption that the terrain properties are locally cylindrical. The calibration curve for pixel brightness versus incidence-angle is also produced. In the operational algorithm, topography is produced as a set of independent line integrations down each of the parallel range lines of the image using the theory for control-profile formation. An adaptive technique was employed to process SEASAT images of sand dunes, and the present method is demonstrated with a Motorola image of Crazy Jug Point in the Grand Canyon.

Wildey, Robert L.↗

X-Band Radar and Surface-Based Observations of Cold-Season Precipitation in Western Colorado’s Complex Terrain

Abstract Hydrologic processes associated with intermountain cold-season precipitation in the Upper Colorado River basin have important impacts on avalanche forecasting and water resource management. However, traditional weather radar networks struggle with observations in this complex terrain. Data collected during the Study of Precipitation, the Lower Atmosphere, and the Surface for Hydrometeorology (SPLASH) and its sister campaign, Surface Atmosphere Integrated Field Laboratory (SAIL) in the East River watershed of western Colorado, are used to examine a multistorm period from 23 December 2021 to 1 January 2022 that contributed 35% of the total winter precipitation in this watershed. Dual-polarization X-band radar and disdrometer measurements show ∼30-mm differences in precipitation amount at two sites in proximity over four distinct storm events within the period. Wind patterns, synoptic forcings, microphysical characteristics of precipitation, and surface meteorology are analyzed to explain the observed spatial variability of cold-season precipitation in complex mountainous terrain. Analysis shows that differences over time within this event are mainly accounted for by synoptic forcings, such as frontal passages; differences between sites are accounted for by the impact of variations in local wind patterns on precipitation microphysics. Patterns of surface precipitation intensity are compared and found to be correlated with X-band radar signatures; a relationship between a strong dendritic growth stage and intense low-density surface precipitation is reinforced by this study. This relationship demonstrates the importance of particle growth mechanisms on surface snowfall patterns in high-altitude complex terrain, underscoring the importance of realistic microphysical parameterizations. Significance Statement The amount and density of snowpack from western Colorado winter storms have significant impacts on water resources in the Upper Colorado River basin. Snowpack characteristics are affected by small-scale differences in how snow forms in the atmosphere. These differences are hard to study in the complex terrain of the Rockies, but data from the SPLASH and SAIL field campaigns allows us to investigate how snow crystal formation and mountain-driven wind patterns affect snow near the surface. Our study finds that snow crystal growth varies over small space and time scales and is likely controlled by the terrain beneath a given location and resultant local wind patterns. These results imply that predicting snowpack in the Rockies requires properly representing local wind patterns and crystal growth processes in models.

Heflin, Stella↗