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All sourcesNASA NTRSDOE OSTI
NASA NTRS2020

Circulating miRNA Signature Predicts Health Risks Associated with Cancer and Spaceflight

Biological risks associated with space radiation and microgravity are major concerns for long-term space travel. Through a Systems Biology approach, our previous NASA work has shown both TGF signaling pathways and miRNAs have a critical impact on defining health risks with and without space irradiation. We hypothesize that circulating microRNA (miRNA) signatures are driving microvascular disease and muscle degeneration associated with accelerating aging and will be enhanced by exposure to the space environment (radiation and microgravity). We are investigating this hypothesis with both in vivo and in vitro models to test novel antagonist therapies to these miRNA signatures as countermeasures to reduce space radiation-induced health risks. A comprehensive Systems Biology approach is utilized to examine the influence by high atomic number by high (H) atomic number (Z) and energy (E) (HZE) irradiation. To simulate low-dose exposure due to galactic cosmic rays (GCR), we used ions, energy, and doses determined by a NASA consensus formula of 7 different ions to represent GCR (referred to as GCR sim model). To similate high-dose radiation exposure due to solar particle events (SPE), we used a solar particle event (SPE) sim model which gave a total dose of 1Gy protons with energy ranges from 50MeV to 150MeV. C57BL/6 wild-type female mice were utilized for the irradiations with our established simulated microgravity model (hindlimb suspension model) and an in vitro 3D microvasculature tissue model under simulated microgravity (clinostat) conditions was also irradiated. To expand on the circulating miRNA signature determined from our preliminary data, we determined a group of conserved miRNAs which are commonly being regulated in the majority of the organs and tissues throughout the host using our established techniques. MiRNA-sequencing was done on serum (at time of sacrifice), liver, heart, and muscle (soleus muscle) tissue for all radiation groups. Additional validation of the key miRNAs was performed by droplet digital PCR (ddPCR). This revealed a key circulating miRNA signature (consisting of multiple miRNAs) impacting cardiovascular and muscular disease risk. Further in vitro experiments with CRISPR/Cas9 system to knockout the key miRNA signatures, novel self-delivering antagomirs, overexpression of the miRNAs test the functional impact of the miRNA signatures on both microvascular disease and muscle degeneration due to space irradiation. The current work has started to allow the possible development of a novel minimally invasive miRNA based radioprotector to be used as a countermeasure for space radiation. Collectively, understanding of how whole body space radiation impacts microvascular and tissue degeneration through circulating miRNAs will greatly enhance health risk prognostication and provide possible new mechanisms for protection against space radiation. This work is supported by the Translational Research Institute through NASA Cooperative Agreement NNX16AO69A (T-0404) awarded to AB.

Beheshti, Afshin↗
DOE OSTI2014

SiC MOSFET Based Single Phase Active Boost Rectifier with Power Factor Correction for Wireless Power Transfer Applications

Wireless Power Transfer (WPT) technology is a novel research area in the charging technology that bridges the utility and the automotive industries. There are various solutions that are currently being evaluated by several research teams to find the most efficient way to manage the power flow from the grid to the vehicle energy storage system. There are different control parameters that can be utilized to compensate for the change in the impedance due to variable parameters such as battery state-of-charge, coupling factor, and coil misalignment. This paper presents the implementation of an active front-end rectifier on the grid side for power factor control and voltage boost capability for load power regulation. The proposed SiC MOSFET based single phase active front end rectifier with PFC resulted in >97% efficiency at 137mm air-gap and >95% efficiency at 160mm air-gap.

active rectifier↗
DOE OSTI2021

Peak Load Management in Distribution Systems Using Legacy Utility Equipment and Distributed Energy Resources: Preprint

The ability to perform peak load management in distribution systems has several benefits for utilities, including reduced demand charges and improved reliability, efficiency, and utilization of the network infrastructure. This paper demonstrates the coordinated operation of an advanced distribution management system (ADMS) and a distributed energy resource management system (DERMS) to achieve peak load management using a realistic laboratory test bed. A commercial ADMS reduces the peak demand by reducing system voltages using a dynamic voltage regulation (DVR) application. A prototype DERMS—based on real-time optimal power flow—controls distributed battery energy storage systems to further reduce the feeder power. Results from the experiments conducted using a model of a real distribution feeder show that the coordinated operation of the ADMS and DERMS is effective in accomplishing peak load management.

61 RADIATION PROTECTION AND DOSIMETRY↗
DOE OSTI2017

Use of Nuclear Divers in Decommissioning of Spent Fuel Pools/Ponds in the United Kingdom - 17431

Magnox Ltd. (Operated by the Cavendish Fluor Partnership) has initiated decommissioning of spent fuel pools/ponds utilizing divers. This decommissioning technique is being employed to disassemble and size reduce underwater equipment and furniture, as well as the collection of sludge and debris prior to draining of the pool. This technique has proven to be highly effective at reducing the radiological exposure to the workforce over previously implemented methods and is expected to significantly reduce overall decommissioning durations and costs. The decommissioning of the UK Nuclear Decommissioning Authority's (NDA) Dungeness A power station spent fuel ponds was initiated in 2015 to eliminate the mobile hazards and prepare the facilities for entry into a Care and Maintenance period. This dual reactor site has two spent fuel ponds each containing 1000 m{sup 3} of water, with the fuel removed since April 2012, which will utilize divers to remove solid wastes from the ponds prior to drain down. This technique has overcome many challenges to implementation including regulatory approval and high airborne contamination. The use of divers for decommissioning was a new technique for the Magnox Sites and required early engagement with the UK Office for Nuclear Regulation (ONR) and the Health and Safety Executive (HSE). The use of plasma arc cutting underwater required the pond area to be classified as an airborne contamination area. The implementation of local ventilation has controlled this hazard. The initial demonstration dives at Dungeness A were completed in April 2016 and the decommissioning dives are expected to be completed in March 2017. This is a substantial improvement to the project schedule and will allow the project completion 5 1/2 years ahead of the Licence Condition milestone. This technique is planned to be implemented at two further NDA Magnox power stations over the next three years. This paper provides the accomplishments and lessons learned to date. (authors)

12 MANAGEMENT OF RADIOACTIVE AND NON-RADIOACTIVE W↗
DOE OSTI2018

Developments in the Regulatory Framework of Interim Storage of Spent Nuclear Fuel (SNF) in Germany - 18137

According to article 6 of the German Atomic Energy Act, storage of nuclear fuel requires a license granted by the competent authority in this field, which is the Federal Office for Safety of Nuclear Waste Management (BfE). In 1995, a license for storage of spent nuclear fuel (SNF) and vitrified high level waste (HAW) was granted for the interim storage facility in Gorleben. Dry Interim storage at the NPP sites in its current form started in 2002 in the interim storage facility next to the nuclear power plant NPP Lingen. Since this time twelve NPPs erected their own storage facilities additionally to the three central storage facilities (Ahaus, Gorleben and Rubenow). In all of these facilities the concept of dry storage in metallic dual purpose casks (DPCs) is implemented. The actual storage licenses for SNF and the HAW (which is stored in Gorleben and Rubenow) are limited to 40 years after closing the transport and storage cask. The first license to expire will be the storage license for the interim storage facility in Gorleben in the year 2034. In Germany the decision about a repository site will be taken in the year 2031. To enable the utilities to hand over the SNF and HAW to the repository regime while the current licenses are still valid would require a very fast process licensing and construction of the required facilities at this location. As a delay cannot be excluded, necessary preparations have to be taken on the side of the regulator. In the German Atomic Energy Act precautions have already been taken and consulting the German parliament (Bundestag) is mandatory if inevitable events would require an extension of the currently licensed interim storage period. The new structure with the Federal Office BfE, and two companies for final disposal 'Bundesgesellschaft fuer Endlagerung' (BGE mbH) and interim storage 'Bundesgesellschaft fuer Zwischenlagerung' (BGZmbH) was established in 2017. The Federal Office for Safety of Nuclear Waste Management (BfE) is responsible for regulation in the field of nuclear disposal since 30.07.2016. So the package design approval for DPCs and the storage licenses for SNF will be granted by this office. Furthermore, it is the regulator for the repository and will finally grant a license for the German deep geological repository. Site selection and construction and operation of the repository will be the responsibility of BGE. On January 1, 2018, the BGZ will take over all remaining interim storage facilities operating under a license due to article six of the Atomic Energy Act. (authors)

12 MANAGEMENT OF RADIOACTIVE AND NON-RADIOACTIVE W↗
DOE OSTI2021

AGGREGATE: dAta-driven modelinG preservinG contRollable dEr for outaGe mAnagemenT and rEsiliency (Final Report)

The AGGREGATE project team successfully developed and validated various modules for outage management. Brief summaries of each module are provided to showcase their strength for outage management and restoration for a distribution system with a high penetration of connected distribution energy resources (DERs). In recent years, inverter-based DERs have been widely deployed in distribution system. A most of behind-the-meter (BTM) solar power generation is not visible to the utility. The data-driven DER and load estimation modules are using machine learning (ML) and artificial intelligence (AI) to manage this issue, which provides an opportunity for distribution system operators (DSOs) to operate systems and make decisions in real-time for a distribution system with a high penetration of DERs deployed. Also, the estimated DER and true load can be further leveraged in network aggregation and cold-load pick up estimation for reducing the computing complexity and providing for fast restoration. After load demand and DER power generations have been estimated, the information will support topology and state estimation (SE). The topology estimation module demonstrated the viability of mixed integer linear programming (MILP) formulation to estimate the most likely operational radial topology and outage sections using power flow measurements, historical/estimated load and DERs data and smart meter ping measurements. Formulation includes continuous (power flow, load and DERs data) and binary measurements (smart meter ping measurements) in a single formulation. Errors in continuous data and binary data are modeled as normal distribution and Bernoulli distribution, respectively. In the future distribution grid, the power injection from controllable DERs will be essential for efficient and resilient grid operation. However, determining the optimal DER injections and restoration actions is dependent on knowledge of the system states. State estimation (SE), already the cornerstone of transmission energy management systems, will become commonplace in distribution management systems as more measurements become available from deployment of automated metering infrastructure (AMI). Observability analysis is the first step in SE, as it determines the sufficiency of the available measurements for accurately estimating the current system states. A new type of pseudo-measurement called a Correlational Measurement (CM) is introduced in this module, to enhance the observability of the system to enable more accurate SE. CMs encapsulate knowledge of correlation between demand patterns for similar classes of loads as well as injection patterns for same-technology renewable DERs. During grid contingency scenarios, DERs have been traditionally disconnected, without any fault ride-through capabilities. However, with new regulations and better technology, it is feasible for these resources to contribute to the grid’s restoration after an adverse event and hence enhance resilience. The controllability module proposes a two-step restoration scheme for the power system restoration process by leveraging additional degrees of freedom in power electronics interfaced DERs for mitigating voltage problems. In a resilience mode without the utility system, the distribution grid relies on DERs to serve critical load. In such a severe event with multiple faults on the distribution feeders, actuation of various protective devices (PDs) divides the distribution system into electrical islands. The undetected actuated PDs due to fault current contributions from DERs can delay the restoration process, thereby reducing the system resilience. The Advanced Outage Management (AOM) and the Advanced Feeder Restoration (AFR) modules developed in this project provide improved system resilience with multiple DERs. AOM identifies the faulted sections and actuated PDs in a distribution system with DERs by incorporating smart meter data. The most credible outage scenario including fault locations, PD actuations, and fault indicator (FI) failures is identified by a set of binary integer linear programming incorporating hypotheses. The AFR module serves to restore a distribution system with available energy resources taking into consideration the availability of utility sources and DERs. By partitioning the system into islands, critical load will be served with the available generation resources within islands based on the solution of a MILP. When the utility systems become available, the optimal path will be determined by a spanning tree search algorithm that reconnects these islands back to substations and restores the remaining load. The transmission and distribution (T&D) co-simulation module was used to validate the effect of a control action performed on the distribution side assets as it propagates to the transmission side. This ensures that the control action performed results in a feasible operating point on both the transmission and the distribution system. In addition to validation, the team used the T&D co-simulation module to demonstrate how distribution system assets can be used to mitigate issues on the transmission system. Specifically, the team demonstrated that appropriate switching operations on the distribution side can alleviate the line overload condition on the transmission side without causing new operational constraint violations.

24 POWER TRANSMISSION AND DISTRIBUTION↗
DOE OSTI2021

Grid Service Values of Generic Marginal Building Flexibility in Modeled 2030 U.S. Power Systems

The datasets include the capacity, energy, and ancillary service values of a marginal kilowatt-hour (kWh) of generic, daily, shiftable building flexibility as a presumed market entrant in the 2030 U.S. power systems. The results should be interpreted along with the caveats listed in "Valuation of Building Flexibility: Grid Service Value for Initial Market Entrants in Projected 2030 United States Power Systems", which also documents the methods used for the study. The factors examined in the study include: grid scenario, region, original usage hour in the day (local time), and building flexibility parameters - efficiency, dissipation, and shifting window include max pre-shift and max post-shift. Filenames in the datasets: The filenames contain information on the grid scenario, and the building flexibility efficiency and dissipation. For example: MidCase_2030_efficiency1.25_dissipation0.05_value.csv contains all results under Mid RE 2020, efficiency = 1.25, and dissipation = 0.05. * MidCase = Mid RE Each .csv file contains: region: The location of the building flexibility, aligned with U.S. Energy Information Administration (EIA) National Energy Modeling System (NEMS) Electricity Market Module regions. max_pre_shift: Part of building flexibility shifting window parameter, indicates the max number of hours the building flexibility can shift earlier. max_post_shift: Part of building flexibility shifting window parameter, indicates the max number of hours the building flexibility can shift later. local_datetime: Original datetime of 1kWh of building energy consumption. local_orig_h: Original usage hour (1-24) of building energy consumption, ignores daylight saving. local_shift_to: The datetime to when building energy consumption shifts, if shifting happens. If no shifting occurs, this cell is left blank. energy: Net energy value of energy shifting. capacity: Net capacity value of energy shifting. shifting_value: Net energy plus capacity value of energy shifting. spin: Spin reserve value at the original datetime of consumption. flex: Flexible reserve value at the original datetime of consumption. reg: Regulation reserve value at the original datetime of consumption. total_profit: Assuming the building flexibility is capable of providing energy, capacity, and ancillary services, total profit is the maximum value of energy shifting value, spin reserve value, flexible reserve value, and regulation reserve value - one of the four choices at any given hour - because we do not allow its value to be double-counted.

32 ENERGY CONSERVATION, CONSUMPTION, AND UTILIZATI↗
NASA NTRS2000

Cell-Mediated Immune Function and Cytokine Regulation During Space Flight

The changes in immune function which occur during space flight potentially expose the crews to an increased risk for development of illness. Decreased cellular immune function has been repeatedly documented after space flight and confirmed during flight by in vivo delayed-type hypersensitivity testing. However, correlation of immune changes with a clinically significant risk factor has not yet been performed. Our hypothesis is that space flight induces a decrease in cell-mediated immune function accompanied by a shift from a type 1 cytokine pattern (favoring cell-mediated immunity) to a type 2 cytokine pattern (favoring humoral immunity). We further hypothesize that reactivation of latent viruses will occur during space flight in association with the decreased cellular immunity. To test these hypotheses, we will determine the effects of space flight on cell-mediated immunity and viral reactivation. We will utilize delayed-type hypersensitivity testing as an in vivo measure of integrated cell-mediated immune function. The production of cytokines and immunoregulatory factors by lymphocytes and monocytes will be measured to determine whether changes in cytokine patterns are associated with the space flight-induced immune dysregulation. Correlation of antigen-specific immune changes with reactivation of latent herpes viruses will be determined by measuring peripheral levels of viral (CMV, VZV, EBV) antigen-specific T cells and comparing to the levels of EBV-infected B-cells by fluorescence in situ hybridization and flow cytometry. A comparison of cell-mediated immune function, cytokine regulation and viral reactivation will provide new insights into crew member health risks during flight.

Sams, Clarence F.↗
DOE OSTI2014

Effect of TGFβ on Na{sup +}/K{sup +} ATPase activity in megakaryocytes

Highlights: • TGFß1 markedly up-regulates Na{sup +}/K{sup +} ATPase in megakaryocytes. • The effect is abrogated by p38-MAP kinase inhibitor skepinone. • The effect is abrogated by SGK inhibitor EMD638683. • The effect is abrogated by NF-κB inhibitor wogonin. - Abstract: The Na{sup +}/K{sup +} ATPase generates the Na{sup +} and K{sup +} concentration gradients across the plasma membrane and is thus essential for cellular electrolyte homeostasis, cell membrane potential and cell volume maintenance. A powerful regulator of Na{sup +}/K{sup +} ATPase is the serum- and glucocorticoid-inducible kinase 1 (SGK1). The most powerful known regulator of SGK1 expression is TGFß1, which is pivotal in the regulation of megakaryocyte maturation and platelet formation. Signaling involved in the upregulation of SGK1 by TGFß1 includes p38 mitogen activated protein (MAP) kinase. SGK1 in turn phosphorylates the IκB kinase (IKKα/β), which phosphorylates the inhibitor protein IκBα thus triggering nuclear translocation of nuclear factor kappa B (NF-κB). The present study explored whether TGFβ influences Na{sup +}/K{sup +} ATPase activity in megakaryocytes, and if so, whether the effect of TGß1 requires p38 MAP kinase, SGK1 and/or NF-κB. To this end, murine megakaryocytes were treated with TGFß1 and Na{sup +}/K{sup +} ATPase activity determined from K{sup +} induced current utilizing whole cell patch clamp. The pump current (I{sub pump}) was determined in the absence and presence of Na{sup +}/K{sup +} ATPase inhibitor ouabain (100 μM). TGFß1 (60 ng/ml) was added in the absence or presence of p38 MAP kinase inhibitor skepinone-L (1 μM), SGK1 inhibitor EMD638683 (50 μM) or NF-κB inhibitor wogonin (50 nM). As a result, the I{sub pump} was significantly increased by pretreatment of the megakaryocytes with TGFß1, an effect reaching statistical significance within 16 and 24 h and virtually abrogated in the presence of skepinone-L, EMD638683 or wogonin. In conclusion, TGFß1 is a powerful regulator of megakaryocytic Na{sup +}/K{sup +} ATPase activity. Signaling mediating the effect of TGFß1 on Na{sup +}/K{sup +} ATPase activity involves p38 MAP kinase, SGK1 and NF-κB.

60 APPLIED LIFE SCIENCES↗
DOE OSTI2016

Ubiquitination independent of E1 and E2 enzymes by bacterial effectors

Signaling by ubiquitination regulates virtually every cellular process in eukaryotes. Covalent attachment of ubiquitin to a substrate is catalyzed by the E1, E2 and E3 three-enzyme cascade 1, which links the C terminus of ubiquitin via an isopeptide bond mostly to the ε-amino group of a lysine of the substrate. Given the essential roles of ubiquitination in the regulation of the immune system, it is not surprising that the ubiquitination network is a common target for diverse infectious agents 2. For example, many bacterial pathogens exploit ubiquitin signaling using virulence factors that function as E3 ligases, deubiquitinases 3 or as enzymes that directly attack ubiquitin 4. The bacterial pathogen Legionella pneumophila utilizes approximately 300 effectors that modulate diverse host processes to create a niche permissive for its replication in phagocytes 5. Here we demonstrate that members of the SidE effector family (SidEs) of L. pneumophila ubiquitinate multiple Rab small GTPases associated with the endoplasmic reticulum (ER). Moreover, we show that these proteins are capable of catalyzing ubiquitination without the need for the E1 and E2 enzymes. The E1/E2-independent ubiquitination catalyzed by these enzymes requires NAD but not ATP and Mg2+. A putative mono ADP-ribosyltransferase (mART) motif critical for the ubiquitination activity is also essential for the role of SidEs in intracellular bacterial replication in a protozoan host. These results establish that ubiquitination can be catalyzed by a single enzyme.

Legionella↗
DOE OSTI2023

A multifunctional copper single-atom electrocatalyst aerogel for smart sensing and producing ammonia from nitrate

Despite modern chemistry’s success in providing affordable fertilizers for feeding the population and supporting the ammonia industry, ineffective nitrogen management has led to pollution of water resources and air, contributing to climate change. Here, we report a multifunctional copper single-atom electrocatalyst-based aerogel (Cu SAA) that integrates the multiscale structure of coordinated single-atomic sites and 3D channel frameworks. The Cu SAA demonstrates an impressive faradaic efficiency of 87% for NH 3 synthesis, as well as remarkable sensing performance with detection limits of 0.15 ppm for NO 3 − and 1.19 ppm for NH 4 + . These multifunctional features enable precise control and conversion of nitrate to ammonia in the catalytic process, facilitating accurate regulation of the ammonium and nitrate ratios in fertilizers. We thus designed the Cu SAA into a smart and sustainable fertilizing system (SSFS), a prototype device for on-site automatic recycling of nutrients with precisely controlled nitrate/ammonium concentrations. The SSFS represents a forward step toward sustainable nutrient/waste recycling, thus permitting efficient nitrogen utilization of crops and mitigating pollutant emissions. This contribution exemplifies how electrocatalysis and nanotechnology can be potentially leveraged to enable sustainable agriculture.

Science & Technology - Other Topics↗
DOE OSTI2017

Design and performance of an X-ray scanning microscope at the Hard X-ray Nanoprobe beamline of NSLS-II

A hard X-ray scanning microscope installed at the Hard X-ray Nanoprobe beamline of the National Synchrotron Light Source II has been designed, constructed and commissioned. The microscope relies on a compact, high stiffness, low heat dissipation approach and utilizes two types of nanofocusing optics. It is capable of imaging with ~15 nm × 15 nm spatial resolution using multilayer Laue lenses and 25 nm × 26 nm resolution using zone plates. Fluorescence, diffraction, absorption, differential phase contrast, ptychography and tomography are available as experimental techniques. The microscope is also equipped with a temperature regulation system which allows the temperature of a sample to be varied in the range between 90 K and 1000 K. The constructed instrument is open for general users and offers its capabilities to the material science, battery research and bioscience communities.

36 MATERIALS SCIENCE↗
DOE OSTI2019

Optimal Operation of Soft Open Points in Active Distribution Networks Under Three-Phase Unbalanced Conditions

The asymmetric integration of distributed generators (DGs) exacerbates the three-phase unbalanced condition in distribution systems. The serious unbalanced operation causes inefficient utilization of network assets and security risks in the system. Soft open point (SOP) is a flexible power electronic device which can achieve accurate active and reactive power flow control to balance the power flow among phases. This paper proposes an SOPs-based operation strategy for unbalanced active distribution networks (ADNs). By regulating the operation of SOPs, the strategy can reduce power losses and simultaneously mitigate the three-phase unbalance of the upper-level grid. Semidefinite programming (SDP) relaxation is advocated to convert the original non-convex, nonlinear optimization model into an SDP formulation, which can be efficiently solved to meet the requirement of rapid adjustment. Case studies are conducted on the modified IEEE 33-node and IEEE 123-node distribution system to verify the effectiveness and efficiency of the proposed strategy.

24 POWER TRANSMISSION AND DISTRIBUTION↗
DOE OSTI2016

Technical Proposal for Loading 3000 Gallon Crude Oil Samples from Field Terminal to Sandia Pressurized Tanker to Support US DOE/DOT Crude Oil Characterization Research Study

Sandia National Laboratories is seeking access to crude oil samples for a research project evaluating crude oil combustion properties in large-scale tests at Sandia National Laboratories in Albuquerque, NM. Samples must be collected from a source location and transported to Albuquerque in a tanker that complies with all applicable regulations for transportation of crude oil over public roadways. Moreover, the samples must not gain or lose any components, to include dissolved gases, from the point of loading through the time of combustion at the Sandia testing facility. In order to achieve this, Sandia designed and is currently procuring a custom tanker that utilizes water displacement in order to achieve these performance requirements. The water displacement procedure is modeled after the GPA 2174 standard “Obtaining Liquid Hydrocarbons Samples for Analysis by Gas Chromatography” (GPA 2014) that is used routinely by crude oil analytical laboratories for capturing and testing condensates and “live” crude oils, though it is practiced at the liter scale in most applications. The Sandia testing requires 3,000 gallons of crude. As such, the water displacement method will be upscaled and implemented in a custom tanker. This report describes the loading process for acquiring a ~3,000 gallon crude oil sample from commercial process piping containing single phase liquid crude oil at nominally 50-100 psig. This document contains a general description of the process (Section 2), detailed loading procedure (Section 3) and associated oil testing protocols (Section 4).

02 PETROLEUM↗
DOE OSTI2019

Incentive-Based Control and Coordination of Distributed Energy Resources. Final Report

The rapid growth of low-inertia renewable energy resources represents an immense opportunity for the U.S. to minimize its carbon footprint, while presenting a challenge for system operators as traditional “spinning” generation resources are displaced. This transformation requires solutions to robustly and cost-effectively manage dynamic changes on the grid while ensuring quality of service. There is growing recognition that distributed energy resources (DERs – loads, distributed generation, storage, electric vehicles, etc.) represent a great potential to perform this function. This report details a scalable hierarchical control strategy for coordinating thousands of heterogeneous DERs in order to provide three ancillary gird services: 1) frequency response, a rapid (within 2 seconds) service used to maintain the grid at 60 Hz; 2) regulation response, a larger response used to balance on-going differences in supply and demand on the grid; and, 3) ramping reserve, used to bring on capacity to replace lost generation. The developed control architecture consists of 1) a Distribution Reliability Coordinator (DRC), 2) aggregator controllers, and finally, 3) DER controllers. The DRC coordinates all the flexible loads and distributed energy resources on the distribution system and bids the aggregate flexibility into the wholesale market. The DRC also performs resource allocation (deciding how the flexible devices on the distribution system will be dispatched) to meet the requirements for each of the three ancillary services. The aggregators control a collection of devices that are geographically co-located and provide a platform to aggregate their flexibility and mitigate uncertainty associated with a single flexible load by managing a large aggregation of similar loads (so that any stochastic effects average out). Finally, DER controllers (for example, thermostats for air conditioners, chargers for electric vehicles) adjust the power consumption of individual devices to ensure accurate and reliable delivery of the requested grid services. Evaluation and validation of this approach was conducted with a mixture of simulation and hardware testing for a range of DERs in residential (air conditioners and water heaters), commercial HVAC (ventilation fans and central chiller plants), and micro-grids (battery energy storage, solar PV etc.). This culminated in DER hardware and simulation models operating in conjunction with grid simulations as part of a large scale federated test-bed demonstration. Simulations of over 10,000 controllable residential devices (a combination of air conditioners, water heaters, batteries, and electric vehicles) demonstrated that this advanced control approach could simultaneously meet all three grid services. Furthermore, hardware-in-the-loop testing was performed with operational micro-grid and commercial building HVAC equipment. The micro-grid equipment (representing PV, battery storage, and back-up generators) demonstrated the ability to meet all frequency response requirements (except ramping time). The commercial building HVAC ventilation equipment successfully provided the regulating response service. An Industry Advisory Board (IAB) was formed and engaged throughout the project to get feed-back on project risks and potential commercialization barriers. Their input was invaluable in identify key risks stemming from regulatory and market access challenges, financial risks from under-performance, and competitive threats from utility-scale solutions such as integrated storage. A phased commercialization plan was developed that addresses continued risk reduction (value proposition refinement and performance uncertainty assessments), piloting through field demonstrations with key stakeholders, and finally, deployment as an emerging standard for DER control.

24 POWER TRANSMISSION AND DISTRIBUTION↗
DOE OSTI2025

Multimetallic Layered Composites (MMLCs) for Rapid, Economical Advanced Reactor Deployment (Final Report)

This project focused on the development of multi-metallic layered composites (MMLCs) for advanced fission reactor technologies. There are many instances where one alloy or material simply cannot meet all the demands thrown at it by a reactor system, or cannot allow it to perform as strongly as one would like. Instead of focusing all our effort on developing one perfect alloy, we seek to leverage the design principle of “separation of functionality,” used in many other arenas in design, to boost performance beyond single alloys alone. One illustrative example shows the power of this approach for molten salt-cooled reactors: A three meter tall, three meter diameter reactor vessel made of Incoloy 800 was quoted at $\$$500k in 2018. A Hastelloy N vessel was quoted at $\$$5M. An MMLC vessel, in which a layer of Hastelloy N would be weld-overlaid onto Incoloy 800, was quoted at $\$$700k, and it would achieve the same performance. The potential economic gains of leveraging this approach are therefore substantial. At a minimum, each MMLC would contain one core structural layer and one coolant-facing corrosion-resistant layer. Sometimes, MMLCs required buffer layers, as the structural and corrosion-resistant layers were metallurgically incompatible. In other words, they didn’t always play nice, thus separating layers compatible with both functioned as intermediaries to keep the composite together. However, in doing so we inevitably produce new interfaces, where new issues can arise. Therefore, this project focused on what happens at these interfaces from a combination of high temperatures, irradiation, corrosion, and time. After all, a reactor makes money when it is operating, and outages of any kind erode its economic viability. First, we set out to experimentally prove that MMLCs for at least two advanced reactor systems can be made, today, in US domestic facilities. In this respect we were successful – one MMLC (a Ni-201/Incoloy 800H composite) was successfully made and drawn into two-inch coolant piping. Others were attempted, though new issues relating to cracking in vanadium layers for one and radiation damage performance of the corrosion-resistant layer in another prevented us from moving further in those specific arenas – these are engineering problems which deserve continued focus after this project. Additional experimental work focused on long-term corrosion testing of the outermost layers of the salt-cooled and liquid lead-cooled MMLC concepts, which would then be fed into predictions of how long the MMLCs could last. Next, computational (thermodynamics and atomistic) simulation studies studied how much we expect the interfaces to “blend,” due to the mixing action of neutron irradiation. This eats into both the margin for the structural layer of each MMLC, as dilution from the corrosion-resistant layer into the structural layer would decrease the total load-bearing capacity of an MMLC of finite size. On the other hand, dilution of the corrosion-resistant layer into the structural layer further reduced the margin of corrodible material, reducing the lifetime of the MMLC or necessitating extra thickness to be imparted to the MMLC to meet its functional requirements. Work here focused on irradiation-induced segregation to predict new phases which may embrittle the MMLCs, as well as quantifying irradiation-induced mixing at each interface. The results showed that mixing is expected, but it is both steady and therefore predictable, and not lifetime-limiting for most MMLC concepts – it simply has to be accounted for in calculations of reactor performance when utilizing an MMLC. Then, full-core simulations using the experimentally-derived corrosion data, the computationally discovered irradiation-induced mixing data (partially validated by experiment), and existing, benchmarked core designs for large and small sized reactor concepts (one salt-cooled, one lead-cooled) were conducted to quantify any expansion of reactor operating envelopes achieved by utilizing these MMLCs. This new framework, called REX (Reactor Envelope Expansion), incorporates a combination of core neutronics, thermal hydraulics, and the material performance data derived from this project to see how using an MMLC expands advanced fission reactor operating envelopes. It was discovered that in some cases, MMLC utilization does indeed increase the maximum operating temperatures and cycle lengths of reactor concepts, while in other cases it does not. Finally, our tech-to-market (T2M) strategy was not necessarily to create specific embodiments of MMLCs for immediate sale (because getting into the nuclear market is incredibly slow and laden with regulation, this is a long-term goal), but rather immediate stimulation of US industry using the design approach of MMLCs derived from this project. In this respect we were successful, as one of the PhD students funded on this project co-founded Allium Engineering, Inc., which created a stainless steel / low-alloy steel MMLC to function as chloride corrosion-resistant rebar for embedding into concrete structures. Allium Engineering continues to be successful, having recently opened their first factory as of this writing.

11 NUCLEAR FUEL CYCLE AND FUEL MATERIALS↗
DOE OSTI2025

Accident Progression and Source Term Demonstration Calculations for the Advanced Burner Test Reactor (ABTR)

As advanced reactor designers approach broad deployment of new reactor technologies and the associated applications, a critical milestone on this path includes licensing or authorization of these designs in the current regulatory environment. Commercial licensing and DOE authorization both consist of numerous aspects to not only certify the designed plant will operate as intended, but also related to confirmation of the safe operation of these facilities that comply with specific standards and requirements. To that end, domestic industry and regulators require toolsets and methods which can be used to confirm that advanced reactor designs not only align with expected performance during normal operation, but also a series of transient scenarios. These codes require a satisfactory validation basis, and in the absence of such a basis, code-to-code comparisons are often utilized as a surrogate to confirm model adequacy. To support this need for fast reactor technologies, a series of analyses using SAS4A/SASSYS- 1 and the Simplified Radionuclide Transport (SRT) code have been conducted for the Advanced Burner Test Reactor (ABTR). These analyses are expected to not only provide a baseline for transient and source term analyses of ABTR, but to also provide context for the key physics that determine evolution of specific transient scenarios in a sodium-cooled fast reactor (SFR). These codes are utilized for this work given their adoption in the SFR industry and by key SFR stakeholders.

22 GENERAL STUDIES OF NUCLEAR REACTORS↗