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At least 1,351 records · Page 75
All sourcesNASA NTRSDOE OSTI
DOE OSTI2022

Tailored approach to study Legionella infection using a lattice light sheet microscope (LLSM)

Legionella is a genus of ubiquitous environmental pathogens found in freshwater systems, moist soil, and composted materials. More than four decades of Legionella research has provided important insights into Legionella pathogenesis. Although standard commercial microscopes have led to significant advances in understanding Legionella pathogenesis, great potential exists in the deployment of more advanced imaging techniques to provide additional insights. The lattice light sheet microscope (LLSM) is a recently developed microscope for 4D live cell imaging with high resolution and minimum photo-damage. We built a LLSM with an improved version for the optical layout with two path-stretching mirror sets and a novel reconfigurable galvanometer scanner ( RGS ) module to improve the reproducibility and reliability of the alignment and maintenance of the LLSM. We commissioned this LLSM to study Legionella pneumophila infection with a tailored workflow designed over instrumentation, experiments, and data processing methods. Our results indicate that Legionella pneumophila infection is correlated with a series of morphological signatures such as smoothness, migration pattern and polarity both statistically and dynamically. Our work demonstrates the benefits of using LLSM for studying long-term questions in bacterial infection. Our free-for-use modifications and workflow designs on the use of LLSM system contributes to the adoption and promotion of the state-of-the-art LLSM technology for both academic and commercial applications.

59 BASIC BIOLOGICAL SCIENCES↗
NASA NTRS1984

An X-ray investigation of the unusual supernova remnant CTB 80

The X-ray properties of SNR CTB 80 (G68.8 + 2.8) are discussed based on both low- and high-resolution images from the Einstein satellite. The X-ray maps show a point source coinciding with the region of maximum radio emission. Diffuse X-ray emission is evident mainly along the radio lobe extending about 8 arcmin east of the point source and aligned with the projected magnetic field lines. The observed X-ray luminosity is 3.2 x 10 to the 34th ergs/s with 1.0 x 10 to the 3th ergs/s from the point source (assuming a distance of 3 kpc). There is also faint, diffuse, X-ray emission south of the point source, where radio emission is absent. The unusual radio and X-ray morphologies are interpreted as a result of relativistic jets energized by the central object, and the possible association of CTB 80 with SN 1408 as recorded by Chinese observers is discussed.

Wang, Z. R.↗
NASA NTRS1989

Broad band X-ray telescope (BBXRT) displacement monitor system (DMS) testing and calibration

NASA's shuttle-borne Broad Band X-Ray Telescope (BBXRT) consists of two glancing incidence imaging mirror assemblies mounted on an optical bench which is bolted to the primary structure of the instrument. The X-ray detectors are located in the focal plane of the mirror assemblies approximately 3.5 meters away. It is desirable to monitor the relative alignment of these components throughout ground testing, and to determine the magnitude of launch or thermally induced perturbations to the alignment during flight. The Displacement Monitor System (DMS) was designed to accomplish this task. This paper describes the design of the DMS, the development and optimization of the DMS calibration facility, and the characterization of the system. The characterization of the DMS includes environmental qualification, displacement vs output calibration over the operating temperature range, a detailed error analysis, and the generation of a calibration polynomial which utilizes DMS detector output and thermocouple data to optimize system performance. The DMS accuracy exceeded the requirements of a 15 arc second limit of error, and passed the stringent environmental tests. As such, the DMS is one of the first flight qualified displacement monitor systems with this accuracy to be flown in space.

Hagopian, John G.↗
NASA NTRS2010

Aligning Astronomical Telescopes via Identification of Stars

A proposed method of automated, precise alignment of a ground-based astronomical telescope would eliminate the need for initial manual alignment. The method, based on automated identification of known stars and other celestial objects in the telescope field of view, would also eliminate the need for an initial estimate of the aiming direction. The method does not require any equipment other than a digital imaging device such as a charge-coupled-device digital imaging camera and control computers of the telescope and camera, all of which are standard components in professional astronomical telescope systems and in high-end amateur astronomical telescope systems. The method could be implemented in software running in the telescope or camera control computer or in an external computer communicating with the telescope pointing mount and camera control computers.

Whorton, Mark↗
NASA NTRS2010

Performance of the Space Telescope Imaging Spectrograph after SM4

On May 17, 2009, during the fourth EVA of SM4, astronauts Michael Good and Mike Massimino replaced the failed LVPS-2 circuit board on the Space Telescope Imaging Spectrograph (STIS), restoring this HST instrument to operation after a nearly 6 year hiatus. STIS after this 2009 repair operates in much the same way as it did during the 2001-2004 period of operations with the Side-2 electronics. Internal and external alignments of the instrument are similar to what they had been in 2004, and most changes in performance are modest. The STIS CCD detector continued to experience radiation damage during the hiatus in operations, leading to decreased charge transfer efficiency (CTE) and an increased number of hot pixels. The sensitivities for most modes are surprisingly close to what was expected from simple extrapolation of the 2003-2004 trends, although the echelle modes show somewhat more complex behavior. The biggest surprise was that the dark count rate for the NUV MAMA detector after SM4 has been much larger than had been expected; it is currently about 2.5 times bigger than it was in 2004 and is only slowly decreasing. We discuss how these changes will affect science with STIS now and in the future.

Proffitt, Charles R.↗
NASA NTRS2015

System and Method for Null-Lens Wavefront Sensing

A method of measuring aberrations in a null-lens including assembly and alignment aberrations. The null-lens may be used for measuring aberrations in an aspheric optic with the null-lens. Light propagates from the aspheric optic location through the null-lens, while sweeping a detector through the null-lens focal plane. Image data being is collected at locations about said focal plane. Light is simulated propagating to the collection locations for each collected image. Null-lens aberrations may extracted, e.g., applying image-based wavefront-sensing to collected images and simulation results. The null-lens aberrations improve accuracy in measuring aspheric optic aberrations.

Hill, Peter C.↗
NASA NTRS2019

Analysis of the Global Microwave Polarization Data of Clouds

Two NASA microwave radiometers, the satellite-borne GPM (Global Precipitation Measurement) Microwave Imager (GMI) and the aircraft-borne CoSMIR (the Conical Scanning Millimeter-wave Imaging Radiometer), measure vertically- and horizontally-polarized microwaves emitted by cloud particles and the Earth below, providing unique information on ice crystal properties in clouds. Their data reveal that non-spherical ice crystals are common and they fall in a preferred horizontally aligned orientation in convective and optically thick clouds especially near cloud top. A bin (particle-size-resolving) microphysical model with an ice crystal shape representation is developed to simulate the evolution of ice crystal properties (i.e., size, shape and orientation), where the radiation effect on microphysics (REM) is taken into account. Since REM represents the effect of all (e.g., both infrared and solar) radiation on ice crystal temperature, it relies upon the ice crystal proprieties that determine how an ice crystal receives radiation. Definitely, REM is different from the radiative effects that cause sensitivity at the microwave frequencies in the GPM and CoSMIR observations. Model results show that horizontally-oriented ice crystals grow faster than vertically-oriented (or spherical) ones due to REM. When both horizontally- and vertically-oriented ice crystals coexist in an air parcel, the model results show that the former grow by vapor deposition whereas the latter shrink by sublimation and disappear eventually. These modeling results are supported by the GMI data and the CoSMIR observations from MC3E (Midlatitude Continental Convective Clouds Experiment) and OLYMPEX (Olympic Mountains Experiment) on the prevalence of horizontally-oriented ice crystals. Moreover, the REM-induced precipitation explains the CloudSat observations of rare thin clouds in the tropical mid-troposphere as well as the common diamond dust in the high latitudes.

Xiping Zeng↗
NASA NTRSDate not supplied

Implementation of a Compact Self-Aligned Focusing Schlieren System for Measurements with the SBLT-II Flight Test Article

Previous flight testing of a supersonic natural laminar flow airfoil on the NASA F-15Baircraft showed evidence of multiple impinging shocks (shock train) of unknown origin, which generated sufficient crossflow on the airfoil to affect the primary measurement goal of transition location. A compact self-aligned focusing schlieren (SAFS) system is being developed to visualize this shock train on the forward surface of the Supersonic Boundary Layer Transition - PhaseII (SBLT-II) flight test article. Details of the design of the SAFS flight system, the constraints imposed by the imaging pod that will be mounted to the F-15B aircraft, preliminary laboratory results obtained with the system, and challenges associated with integrating the imaging system into the aircraft are presented. The resulting schlieren images obtained from this flight test will allow for a three-dimensional reconstruction of the unknown shock structure, validating the use of SAFS for flight testing.

Joshua M. Weisberger↗
DOE OSTI2012

Separating intrinsic alignment and galaxy-galaxy lensing

The coherent physical alignment of galaxies is an important systematic for gravitational lensing studies as well as a probe of the physical mechanisms involved in galaxy formation and evolution. We develop a formalism for treating this intrinsic alignment (IA) in the context of galaxy-galaxy lensing and present an improved method for measuring IA contamination, which can arise when sources physically associated with the lens are placed behind the lens due to photometric redshift scatter. We apply the technique to recent Sloan Digital Sky Survey (SDSS) measurements of Luminous Red Galaxy lenses and typical ( ∼ L{sub *}) source galaxies with photometric redshifts selected from the SDSS imaging data. Compared to previous measurements, this method has the advantage of being fully self-consistent in its treatment of the IA and lensing signals, solving for the two simultaneously. We find an IA signal consistent with zero, placing tight constraints on both the magnitude of the IA effect and its potential contamination to the lensing signal. While these constraints depend on source selection and redshift quality, the method can be applied to any measurement that uses photometric redshifts. We obtain a model-independent upper-limit of roughly 10% IA contamination for projected separations of r{sub p} ≈ 0.1–10 h{sup −1}Mpc. With more stringent photo-z cuts and reasonable assumptions about the physics of intrinsic alignments, this upper limit is reduced to 1–2%. These limits are well below the statistical error of the current lensing measurements. Our results suggest that IA will not present intractable challenges to the next generation of galaxy-galaxy lensing experiments, and the methods presented here should continue to aid in our understanding of alignment processes and in the removal of IA from the lensing signal.

79 ASTRONOMY AND ASTROPHYSICS↗
DOE OSTI2013

IMAGING THE DISK AND JET OF THE CLASSICAL T TAURI STAR AA TAU

Previous studies of the classical T Tauri star AA Tau have interpreted the UX-Orionis-like photo-polarimetric variability as being due to a warp in the inner disk caused by an inclined stellar magnetic dipole field. We test that these effects are macroscopically observable in the inclination and alignment of the disk. We use Hubble Space Telescope (HST)/STIS coronagraphic imagery to measure the V magnitude of the star for both STIS coronagraphic observations, compare these data with optical photometry in the literature, and find that, unlike other classical T Tauri stars observed in the same HST program, the disk is most robustly detected in scattered light at stellar optical minimum light. We measure the outer disk radius, 1.''15 {+-} 0.''10, major-axis position angle, and disk inclination and find that the inner disk, as reported in the literature, is both misinclined and misaligned with respect to the outer disk. AA Tau drives a faint jet, detected in both STIS observations and in follow-on Goddard Fabry-Perot imagery, which is also misaligned with respect to the projection of the outer disk minor axis and is poorly collimated near the star, but which can be traced 21'' from the star in data from 2005. The measured outer disk inclination, 71 Degree-Sign {+-} 1 Degree-Sign , is out of the range of inclinations suggested for stars with UX-Orionis-like variability when no grain growth has occurred in the disk. The faintness of the disk, small disk size, and detection of the star despite the high inclination all indicate that the dust disk must have experienced grain growth and settling toward the disk midplane, which we verify by comparing the observed disk with model imagery from the literature.

79 ASTRONOMY AND ASTROPHYSICS↗
NASA NTRS2013

Imaging the Disk and Jet of the Classical T Tauri Star AA Tau

Previous studies of the classical T Tauri star AA Tau have interpreted the UX-Orionis-like photo-polarimetric variability as being due to a warp in the inner disk caused by an inclined stellar magnetic dipole field. We test that these effects are macroscopically observable in the inclination and alignment of the disk. We use Hubble Space Telescope (HST)/STIS coronagraphic imagery to measure the V magnitude of the star for both STIS coronagraphic observations, compare these data with optical photometry in the literature, and find that, unlike other classical T Tauri stars observed in the same HST program, the disk is most robustly detected in scattered light at stellar optical minimum light.We measure the outer disk radius, 1 inch.15 plus-minus 0 inch.10, major-axis position angle, and disk inclination and find that the inner disk, as reported in the literature, is both misinclined and misaligned with respect to the outer disk. AA Tau drives a faint jet, detected in both STIS observations and in follow-on Goddard Fabry-Perot imagery, which is also misaligned with respect to the projection of the outer disk minor axis and is poorly collimated near the star, but which can be traced 21 inches from the star in data from 2005. The measured outer disk inclination, 71deg plus-minus 1deg, is out of the range of inclinations suggested for stars with UX-Orionis-like variability when no grain growth has occurred in the disk. The faintness of the disk, small disk size, and detection of the star despite the high inclination all indicate that the dust disk must have experienced grain growth and settling toward the disk midplane, which we verify by comparing the observed disk with model imagery from the literature.

Cox, Andrew W.↗
DOE OSTI2014

SU-F-BRF-10: Deformable MRI to CT Validation Employing Same Day Planning MRI for Surrogate Analysis

Purpose: To compare rigid and deformable registrations of the prostate in the multi-modality setting (diagnostic-MRI to planning-CT) by utilizing a planning-MRI as a surrogate. The surrogate allows for the direct quantitative analysis which can be difficult in the multi-modality domain where intensity mapping differs. Methods: For ten subjects, T2 fast-spin-echo images were acquired at two different time points, the first several weeks prior to planning (diagnostic-MRI) and the second on the same day in which the planning CT was collected (planning-MRI). Significant effort in patient positioning and bowel/bladder preparation was undertaken to minimize distortion of the prostate in all datasets. The diagnostic-MRI was deformed to the planning-CT utilizing a commercially available deformable registration algorithm synthesized from local registrations. The deformed MRI was then rigidly aligned to the planning MRI which was used as the surrogate for the planning-CT. Agreement between the two MRI datasets was scored using intensity based metrics including Pearson correlation and normalized mutual information, NMI. A local analysis was performed by looking only within the prostate, proximal seminal vesicles, penile bulb and combined areas. A similar method was used to assess a rigid registration between the diagnostic-MRI and planning-CT. Results: Utilizing the NMI, the deformable registrations were superior to the rigid registrations in 9 of 10 cases demonstrating a 15.94% improvement (p-value < 0.001) within the combined area. The Pearson correlation showed similar results with the deformable registration superior in the same number of cases and demonstrating a 6.97% improvement (p-value <0.011). Conclusion: Validating deformable multi-modality registrations using spatial intensity based metrics is difficult due to the inherent differences in intensity mapping. This population provides an ideal testing ground for MRI to CT deformable registrations by obviating the need for multi-modality comparisons which are inherently more challenging. Deformable registrations generated in this work significantly outperformed rigid alignments. Research reported in this abstract was supported by the NIH National Cancer Institute R21CA153826 “MRI-Guided Radiotherapy and Biomarkers for Prostate Cancer” and Bankhead-Coley Cancer Research Program 10BT-03 “MRI-Guided Radiotherapy and Biomarkers for Prostate Cancer”.

60 APPLIED LIFE SCIENCES↗
DOE OSTI2025

Shock compression of additively manufactured high solids loaded polymer composites with aligned porosity

The effects of aligned porosity on the shock-compression response of additively manufactured (AM) composite structures with collinear and log-cabin geometries are investigated. The composites contain two inorganic and two organic particle populations and a UV-curable polymer binder. X-ray phase contrast imaging (X-PCI) is used as an in-material diagnostic in plate-impact experiments performed at the Dynamic Compression Sector of the Advanced Photon Source at the Argonne National Laboratory. Macroscale shock and particle velocities and microscale pore collapse velocities are measured from X-PCI images obtained from samples impacted in various orientations relative to the AM build directions. The linear shock and particle velocity relation for the structures with collinear build geometry shows directional differences, with the build direction exhibiting the highest slope and the filament print direction having the shallowest slope. Composites with log-cabin geometry, due to their slightly lower porosity and smaller sized pores, show higher shock velocities than the collinear structures at the same particle velocity. Microscale directionality effects are also observed, with the pore collapse velocity dependent on the pore configuration. Specifically, the pore collapse velocity is highest for pores elongated along the impact direction which is the case for the colinear structures impacted in the filament print direction, which is consistent with the directionality trend observed in the data for the shock and particle velocity equation of state. The pore collapse velocity approaches ∼80 % of the shock velocity and is several times the average bulk particle velocity, suggesting a highly hydrodynamic mechanism of pore collapse. Overall, both the macroscale response as measured by the shock and particle velocity relationship, and the microscale response as measured by the pore collapse velocity, are found to be anisotropic and dependent on the AM composite structure.

Wagner, K. B. [Georgia Institute of Technology, At↗
DOE OSTI2024

Influence of Concentration Gradients on Electroconvection at a Cation-Exchange Membrane Surface

Membrane-based systems, such as electrodialysis, play an important role in desalination and industrial separation processes. Electrodialysis uses alternating anion- and cation-exchange membranes with a perpendicular electric field to generate concentrated and diluate streams from a feed solution. It is known that under overlimiting current conditions, reduced charge and mass transfer at the membrane interface leads to regions of high ion depletion generating instability and vortices termed electroconvection. While electroconvective mixing is known to directly impact the separation efficiency of electrodialysis, the influence of ion concentration gradients across the membrane experienced in a functional electrodialysis system is not known. Here, we report the influence of ion concentration gradients across a cation exchange membrane (Nafion) that is both aligned with and opposed to the applied electric field. Experiments were conducted by coflowing NaCl solutions of different concentrations (0.1–100 mM) on each side of the membrane, and electroconvection was visualized with a fluorescence dye (Rhodamine 6G). Here, we obtained concentration profiles from fluorescence image data and systematically measured the thickness of the depletion boundary layer d BL under different conditions. We found smaller d BL values at a higher flow rate both with and without concentration gradients. Our results show that electroconvection is enhanced when the electric field is opposite to the direction of the concentration gradient.

37 INORGANIC, ORGANIC, PHYSICAL, AND ANALYTICAL CH↗
DOE OSTI2012

KELT-1b: A STRONGLY IRRADIATED, HIGHLY INFLATED, SHORT PERIOD, 27 JUPITER-MASS COMPANION TRANSITING A MID-F STAR

We present the discovery of KELT-1b, the first transiting low-mass companion from the wide-field Kilodegree Extremely Little Telescope-North (KELT-North) transit survey. A joint analysis of the spectroscopic, radial velocity, and photometric data indicates that the V = 10.7 primary is a mildly evolved mid-F star with T{sub eff} = 6516 {+-} 49 K, log g 4.228{sup +0.014}{sub -0.021}, and [Fe/H] = 0.052 {+-} 0.079, with an inferred mass M{sub *} = 1.335 {+-} 0.063 M{sub Sun} and radius R{sub *} 1.471{sup +0.045}{sub -0.035} R{sub Sun }. The companion is a low-mass brown dwarf or a super-massive planet with mass M{sub P} = 27.38 {+-} 0.93 M{sub Jup} and radius R{sub P} = 1.116{sup +0.038}{sub -0.029} R{sub Jup}. The companion is on a very short ({approx}29 hr) period circular orbit, with an ephemeris T{sub c} (BJD{sub TDB}) = 2455909.29280 {+-} 0.00023 and P = 1.217501 {+-} 0.000018 days. KELT-1b receives a large amount of stellar insolation, resulting in an estimated equilibrium temperature assuming zero albedo and perfect redistribution of T{sub eq} = 2423{sup +34}{sub -27} K. Comparison with standard evolutionary models suggests that the radius of KELT-1b is likely to be significantly inflated. Adaptive optics imaging reveals a candidate stellar companion to KELT-1 with a separation of 588 {+-} 1 mas, which is consistent with an M dwarf if it is at the same distance as the primary. Rossiter-McLaughlin measurements during transit imply a projected spin-orbit alignment angle {lambda} = 2 {+-} 16 deg, consistent with a zero obliquity for KELT-1. Finally, the vsin I{sub *} = 56 {+-} 2 km s{sup -1} of the primary is consistent at {approx}2{sigma} with tidal synchronization. Given the extreme parameters of the KELT-1 system, we expect it to provide an important testbed for theories of the emplacement and evolution of short-period companions, as well as theories of tidal dissipation and irradiated brown dwarf atmospheres.

79 ASTRONOMY AND ASTROPHYSICS↗
DOE OSTI2025

Tracing cosmic gas in filaments and halos: Low-redshift insights from the kinematic Sunyaev-Zel’dovich effect

In this work, we leverage cosmic microwave background (CMB) data from the Atacama Cosmology Telescope (ACT) and LSS data from the imaging survey conducted by the Dark Energy Spectroscopic Instrument (DESI) to study the distribution of gas around galaxy groups at low redshift, z ≈ 0.3, via the kinematic Sunyaev-Zel'dovich (kSZ) effect. In particular, we perform velocity-weighted stacking on the photometric galaxies from the Bright Galaxy Survey (BGS) to isolate the monopole and quadrupole of the kSZ signal, orienting the stacked images along 2D filaments identified using the Hessian of the projected gravitational potential. We find a 7.2σ detection in the monopole of the signal (i.e., the gas density profile) and a 4σ detection in the quadrupole (m = 2), constituting the first measurement of the alignment between gas distribution and the cosmic web through the kSZ effect. As it is a linear probe of the local gas density, the kSZ has heightened sensitivity to the warm-hot intergalactic medium (WHIM), which is believed to house the majority of the "missing baryons."Mapping out the gas density at low redshifts, as enabled by our measurements, is crucial for weak lensing surveys, for which the impact of baryons on small scales is a major impediment. We compare the anisotropic signal against two hydrodynamical simulations, TNG300-1 and Illustris, which have very different baryonic feedback prescriptions. We find that the anisotropic signal measured in the data is comparable but slightly larger and more extended compared with the simulations. Further, this suggests that there is excess accretion and feedback taking place through the filaments, hinting at the possible presence of spin-filament alignment of the BGS objects.

79 ASTRONOMY AND ASTROPHYSICS↗
DOE OSTI2021

Visualization of Fast Ion Phase-Space Flow Driven by Alfvén Instabilities

Fast ion phase-space flow, driven by Alfven eigenmodes (AEs), is measured by an imaging neutral particle analyzer in the DIII-D tokamak. The flow firstly appears near the minimum safety factor at the injection energy of neutral beams, and then moves radially inward and outward by gaining and losing energy, respectively. The flow trajectories in phase space align well with the intersection lines of the constant magnetic moment surfaces and constant E – (ω/n)P ζ surfaces, where E, P ζ are energy and toroidal canonical momentum of ions; ω and n are angular frequencies and toroidal mode numbers of AEs. It is found that the flow is so destructive that the thermalization of fast ions is no longer observed in regions of strong interaction. Here, the measured phase-space flow is consistent with nonlinear hybrid kinetic-magnetohydrodynamics simulation. Calculations of the relatively narrow phase-space islands reveal that fast ions must transition between different flow trajectories to experience large-scale phase-space transport.

70 PLASMA PHYSICS AND FUSION TECHNOLOGY↗
DOE OSTI2025

Image-Driven Hybrid Structural Analysis Based on Continuum Point Cloud Method with Boundary Capturing Technique

Conventional approaches for the structural health monitoring of infrastructures often rely on physical sensors or targets attached to structural members, which require considerable preparation, maintenance, and operational effort, including continuous on-site adjustments. This paper presents an image-driven hybrid structural analysis technique that combines digital image processing (DIP) and regression analysis with a continuum point cloud method (CPCM) built on a particle-based strong formulation. Polynomial regressions capture the boundary shape change due to the structural loading and precisely identify the edge and corner coordinates of the deformed structure. The captured edge profiles are transformed into essential boundary conditions. This allows the construction of a strongly formulated boundary value problem (BVP), classified as the Dirichlet problem. Capturing boundary conditions from the digital image is novel, although a similar approach was applied to the point cloud data. It was shown that the CPCM is more efficient in this hybrid simulation framework than the weak-form-based numerical schemes. Unlike the finite element method (FEM), it can avoid aligning boundary nodes with regression points. A three-point bending test of a rubber beam was simulated to validate the developed technique. The simulation results were benchmarked against numerical results by ANSYS and various relevant numerical schemes. The technique can effectively solve the Dirichlet-type BVP, yielding accurate deformation, stress, and strain values across the entire problem domain when employing a linear strain model and increasing the number of CPCM nodes. In addition, comparative analysis with conventional displacement tracking techniques verifies the developed technique’s robustness. The proposed technique effectively circumvents the inherent limitations of traditional monitoring methods resulting from the reliance on physical gauges or target markers so that a robust and non-contact solution for remote structural health monitoring in real-scale infrastructures can be provided, even in unfavorable experimental environments.

Chemistry↗